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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
While CD34 cells gave rise to all lineages in in vitro CFU assays, CD34 cells produced fewer colonies overall, with a less efficient differentiation towards myeloid lineage compared to CD34.
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PMC11577421
Notably, albumin interacts with the cellular glycocalyx, a phenomenon particularly studied in endothelial cells.
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PMC11694625
Hence, as the potential anticancer compounds, 3b and 3c were selected for further anticancer mechanism exploration.
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PMC11697703
The DOIs of key resources are listed in the key resources table.
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PMC10158546
To examine prion replication in differentiated ReN cultures, ReN-PrP, ReN-PrP and ReN-PrP cells were differentiated for one week, then inoculated with one of four prion isolates.
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PMC11703896
Docking score of rapamycin indicated its potential to bind with ALK receptor.
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PMC11627398
According to the DEGs listed in the S3 Table, GO and KEGG analyses were performed.
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PMC11335267
In vWAT, the activity of PCK1 is directly regulated by the sympathetic tone, as assessed by reduced levels of triacylglycerol in adipocytes after sympathectomy .
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PMC10858941
DPM Manager and Fiji ImageJ Softwares were used to process the pictures.
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PMC11371627
To analyse expression of Kell protein antigens Kell (K, K1) and Cellano (k, K2) on RBCs, FACS analysis of whole blood was performed with anti-K and anti-k antibodies.
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PMC11604830
In terms of proton concentration, PFCE‐NE displayed the highest concentration (6.35 M of protons, corresponding to 7.77 x 10 NPs/ml), while the concentration of DSPE‐PEG2000‐associated protons in PEG‐MIC and PEG‐LIPO suspension was lower (0.99 and 0.57 M, respectively).
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PMC9429973
Heterogeneous MRD responses were observed for other molecular subtypes (poor: ZNF384 - 48.2% MRD neg.,
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PMC10094712
Since SELENOM is structural homologue of SELENOF, that’s why it may be also involved in the regulation of similar processes in human cancer cell lines; however, this assumption requires further confirmation using other independent approaches.
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PMC11471157
Papanicolaou staining of DFP. (
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PMC9739791
Thus, flexible linkers of Pt(IV) prodrugs 19 and 23 facilitate the photoreduction process by adopting the optimal conformation for electron transfer.
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PMC11629461
Bar graphs showing means with 95% CI indicated.
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PMC11694066
Exposure to PARPi and ATRi further activated the cyclic GMP–AMP synthase–stimulator of IFN genes (cGAS–STING) pathway and caused PD-L1 upregulation in DSRCT cell lines, suggesting potential for these drugs as DNA repair–targeted therapies and immunomodulators in DSRCT.
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PMC8316344
Cell death (G, H) and lipid ROS generation (I, J) and GSH levels (K, L) were measured by staining with Sytox green (G, H) and C11-BODIPY (I, J) following flow cytometry and a GSH assay kit (K, L) in Bel-7404 and SK-Hep1 cells with or without knockout and overexpression of TRIB2, in the presence or absence of βTrCP following treating with RSL3 (5 µM, 12 h) or erastin (10 µM, 12 h) with or without DFO (25 µM, 12 h).
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PMC7642379
A Mann–Whitney U-test was used to compare normalized counts based on library size between the two groups for each of the 38 differentially expressed genes.
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PMC11594588
Diacylglycerols, by activating C-kinases (PKCs), intensify cellular insulin resistance, and in a feedback mechanism, as well as in ROS production, the creation of oxidative stress, and inflammatory processes .
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PMC10237474
Expression vectors were in-house engineered to be compatible with the PB system by inserting inverted terminal repeat sequences (ITRs) flanking GOIs.
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PMC11438317
E, LYP expression in PLB treated with PHA.
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PMC9429973
2020;38:2849-2861).
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PMC11335267
On the other hand, the undetected expression of Alx3 in major peripheral organs directly involved in metabolic regulation indicates that a primary dysfunction in these organs is unlikely to generate the observed phenotype.
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PMC11725127
The interaction between USP2 and GA follows a two-step mode for covalent inhibitors.
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PMC11365983
Quantification confirms the significant decrease in the mean signal intensity of the active phosphorylated form of Pdgfrα, and comparable reductions in the level of the tight junction protein Zo1, relative to wild-type embryos. (
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PMC11352666
TC106, TC32, RD-ES cell lines were cultured in RPMI medium, A673 was cultured in DMEM, and U2OS and SK-ES-1 were cultured in McCoy medium.
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PMC11686380
pCAG-Turbo-RFP was co-electroporated with pSuper-H1.shLuc (Control), pSuper-mGAP43#1 (KD#1), or KD#1 plus pCAG-Myc-GAP43R (KD#1 + R) at E14.5 and fixed at P2.
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PMC11703992
C The MR estimates of significant exposures on GCA in test dataset.
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PMC9429973
The COTA database is a USA-based dataset composed of longitudinal, de-identified data on the diagnosis, clinical management, and outcomes of patients with cancer.
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PMC11548041
To evaluate their uptake efficiency by EpCAM-positive cells, MNVs were first functionalized with 0.1 µM or 1 µM Cy5-PLD01-TEG-Chol-modified aptamer or left unfunctionalized as plain controls.
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PMC10198699
Assuming that the research institution makes the incorrect representation because it sincerely believes it to be legally possible, the research institution would become the bona fide possessor of the tissue sample.
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PMC11589157
The distribution of ncRNAs on each chromosome is depicted Fig. 3E.
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PMC9429973
We found that this is independent of the iPSCs donors (testing in different batches an iPSC donors).
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PMC11366496
2.3) Empirical Bayes method: Use information from the overall data to estimate and adjust the effects of each batch. (
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PMC6182045
Comparative bNAb binding affinities for TZ97008-rgp120 produced in CHO-S or MGAT1– CHO cells.
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PMC11628309
It seems that enhanced lysosomal cholesterol levels might be a protective mechanism induced after mitochondrial disfunction which may help to prevent lysosome membrane permeabilization (Appelqvist et al., 2012; Eriksson et al., 2017).
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PMC11224020
By contrast, IKKβ inhibition had no effect on nuclear accumulation of cPLA2 in confined DCs (Fig. 6k).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "contrast", ",", "IKKβ", "inhibition", "had", "no", "effect", "on", "nuclear", "accumulation", "of", "cPLA2", "in", "confined", "DCs", "(", "Fig.", "6k", ")", "." ] } ]
PMC9429973
WGS revealed a 10.08 kb genomic deletion which truncated UBTF at exon 17/21 and comprised most of the intergenic region between both genes (Figure B).
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PMC9429973
Summary/Conclusion: Generic Elthrombopag is a potential alternative to innovator molecule for treating the severe aplastic anemia triple drug regimen.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Generic", "Elthrombopag", "is", "a", "potential", "alternative", "to", "innovator", "molecule", "for", "treating", "the", "severe", "aplastic", "anemia", "triple", "drug", "regimen", "." ] } ]
PMC9261184
The NETL study comparison is for the USA—Rotterdam case study voyage using a DFDE vessel.
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PMC7039683
Average density of H3K27Ac ChIP-seq signal in NHEK and GM12878 cells (Visel et al., 2008) at top 0.1% tiles using a zGPAE-trained classifier. (
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PMC11640476
The optimal λEx-λEm combination for A549 cell lines treated with 44 µM Resazurin WS was determined by evaluating 12 different λEx-λEm combinations across 3 different cell confluences: low, medium, and high.
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PMC11730311
Standard couplings were performed by adding the 5 equivalents amino acid solution [0.5 M in DMF (N-methyl-2-pyrrolidone (NMP) for Phe) containing 0.5 M ethyl 2-cyano-2-(hydroxyimino)acetate (OxymaPure)] followed by addition of 1.0 M solution of N,N'-diisopropylcarbodiimide (DIC) (5 equivalents) in DMF.
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PMC11047729
The dysregulation of the human telomerase gene is a well-documented event in the development of leukemia .
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PMC10747139
Moreover, the authors suggest albumin protein as a possible vehicle for the transportation and delivery of the complexes through the establishment of hydrophobic interactions.
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PMC9424261
E HERPUD1, HMGCS1, and GDF15 expression were measured by immunoblotting in liver cancer cell lines (Bel-7402 and Bel-7404), as indicated.
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PMC11365983
Significance codes ***P < 0.001, **P < 0.01, *P < 0.05.
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PMC9429973
Meanwhile, greater proportions of patients in L-MT and B-MT group had high-risk cytogenetic abnormalities (HRCA), defined as amplification 1q21, deletion 17p, t(4,14), t(14,16).
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PMC6684588
For example, 55% of fibers from ACE-083-injected TA muscles were at least 50 μm in diameter, whereas only 18% of fibers from contralateral, uninjected TA muscles were that size (Fig. 3d).
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PMC11297139
The tumors generated by ARID1A LLPS-positive cells showed notably larger in volume than LLPS-negative cells (Fig. 3h).
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PMC7022782
On the basis of these results, we decided to study the loading of PECA-NPs with a fluorescent dye to improve the usefulness of previously prepared NPs in cancer management.
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PMC9847912
Each point is the mean of four cultures that were maintained in parallel.
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PMC11727062
The Four Natures mainly include cold, cool, warm, and hot, which represent the corresponding reactions that occur within the body after the administration of Chinese herbs.
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PMC11594074
All wells were covered with Parafilm M and incubated at 37 °C for 60 min.
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PMC9429973
Analysis of BH3 protein expression and sensitivity to BH3 mimetics in PI resistant cell lines were performed via western blot and viability assays, respectively.
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PMC11082662
In addition, the function of SMPDL3B is not limited to this.
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PMC11530949
The FESEM analysis, depicted in Figure 1A, illustrated spherical particles within the size range of 31.27 to 88.98 nanometers, while the Energy-Dispersive X-ray Spectroscopy (EDS) analysis, shown in Figure 1C, confirmed a silver content of 3.66% and copper content of 2.24%.
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PMC9429973
Patients enrolled were planed to treat with Zanubrutinib combined with rituximab (Zanubrutinib 160 mg orally twice daily and rituximab 375 mg/m day1 iv, every 28 days, ZR regimen), for a total of eight courses.
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PMC11782508
Moreover, a previous study reported that recombinant azurin revealed a high inhibitory effect against bacterial growth and biofilm formation of Salmonella typhi and Vibrio cholera.
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PMC8973085
The antiproliferative evaluation against (HCT-116, HepG-2, and MCF-7) human cancer cells and one human healthy cell line (BJ-1) revealed that compounds 3b, 4c–5d, 7b–12a, 10d, and 13b have interesting antitumor activity specifically as antihepatocellular and anticolon cellular carcinoma agents.
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PMC11098378
We next transfected either wild-type or mutant effector expression constructs into LD652 cells to determine: 1) if these Flag-tagged effectors could rescue arbovirus replication and 2) if known or putative enzymatic functions were required for viral rescue.
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PMC9429973
Based on favorable pre-clinical results using our novel CAR-T-anti BCMA construct, in February 2021 we have launched a BCMA-targeted CAR-T cell based clinical trial treating relapsed refractory (R/R) multipe myeloma (MM) patients (NCT04720313).
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PMC10882807
Cell proliferation ability was assessed by Colony formation assays after knocking down of hsa_circ_0005397 in BEL-7404 cells. (
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PMC11585994
293T cells were used as packaging cells for viral production, and transfections of pCDH-BCL11B-puroR, psPAX2, and pMD2.G were carried out using Polyethylenimine linear (PEI, YEASEN, 40816ES02).
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PMC10671321
The rat Ache sequence was inserted into the pEFBos plasmid .
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PMC10956161
Clinical data for 541 lung adenocarcinoma samples were downloaded, but 24 had incomplete or missing clinical data so they were excluded from these analyses.
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PMC11128598
Next, we studied the effect of Panobinostat (LBH) on the proliferation of the different cancer cell lines.
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PMC6133382
The discovery that multiple bN-mAbs to HIV recognize glycan-dependent epitopes has altered our thinking of how best to produce this vaccine.
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PMC11753435
Targeted protein degradation has emerged as a promising alternative to treat disease but largely relies on small-molecule warheads to bind and recruit endogenous E3 ubiquitin ligases to targets, thus still requiring the presence of accessible surface-binding sites (3).
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PMC9587298
As far as we know, this work is the first approach that evaluated the potential cytoprotective/antiglycative effect of elderberries against the deleterious effects of MGO, using Caco-2 and HepG2 cells.
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PMC8956657
One notable study found that, in the context of MERS-CoV infection, ORF4b blocks the nuclear translocation of the p65 subunit of the NF-ĸB heterodimer, thereby blocking NF-ĸB-dependent cytokine production.
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PMC10713411
To explore the cross-talk among these 9 PRPCDGs in KIRC, the expression of them was analyzed by the Pearson correlation coefficient (Supplementary Figure 4A).
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PMC11528603
The scale bars represent 50 µm.
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PMC11703992
A total of 3000 cells were added to each well, and the experiment was conducted after an 8 h incubation period.
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PMC7081114
BEL-7404 cells were transfected with shKIF21B or shCtrl.
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PMC11756937
They both offer a distinct advantage over lenti/retroviral reprogramming due to their lack of genomic integration, potentially resulting in transgene-free and genomically stable iPSCs.
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PMC3019555
Right column shows the percentage of overlap (mean ± SEM; n = 3) between Ago2 foci and HIF-1α MB (***, P < 0.001; Videos 6 and 7).
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PMC7685376
A large number of differentially expressed proteins were observed between the control group and Huaier group in Bel-7404 cells (Figure 1D).
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PMC11401350
Finally, we also confirmed a significant shift toward central memory (CMT, CD62L + CD44 +) and effector memory T cells (EMT, CD62L-CD44 +), while the naïve T cells were reduced (TN, CD62L + CD44 low) for the CD34 + CD8 T cell subset as compared to the CD34- CD8 T cells (Supplementary Fig. 4 and Fig. 4H).Fig.
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PMC11453018
Despite their crucial role in cellular processes, the specific function of P300/CBP in ES remains uncharted .
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PMC9429973
All cass came from delta region 70 % from Dakahlia governorate.
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PMC11704135
These kinases play crucial roles in promoting tumor cell proliferation, angiogenesis, and metastasis.
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PMC9220170
Protein evaluation was carried out in different samples according to the Lowry method.
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PMC11678368
This indicates that chloro-substitution in the ligand of the platinum complex enhances its cytotoxicity in colon cancer models.
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PMC7602170
Activation of AKT depends on phosphorylating serine473 (Ser473) by mTORC2 and threonine 308 (Thr308) by PDK1, respectively (Figure 2).
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PMC6600253
Considering the safety profiles of stilbene compounds, the majority of studies have indicated that RSV and PT are well tolerated and do not produce marked toxicity .
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PMC10747160
This allowed HEK 293T-hACE2+ cells to adhere to wells and Raji cells to fall to the bottom of wells.
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PMC11718809
All experimental protocols and procedures were approved by the Animal Management Ethics Committee of the Lanzhou Institute of Animal Science and Veterinary Medicine, Chinese Academy of Agricultural Sciences (Permit No. SYXK-2014-0002).
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PMC9429973
The CRR at 6 months was 50.0% in eltrombopag cohort and 10.2% in control cohort.
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PMC11653168
To investigate the effects of Stattic on apoptosis and autophagy, CCRF-CEM (Fig. 5A) and Jurkat cells (Fig. 5B) were treated with increasing concentrations of Stattic (1.25, 2.5 and 5 µM) or vehicle control (DMSO) for 24 h. Protein expression levels of apoptotic markers (pro-caspase-3, cleaved caspase-3) and autophagy markers (LC3B, p62) were assessed by western blotting, with β-actin used as a loading control.
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PMC9429973
Most CRS events occurred in cycle 1, and all CRS events resolved with standard management (median time to resolution, 3 d; range, 1–8).
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PMC11694346
Low cytotoxicity and high time resolution make BT-DNBS suitable for live-cell imaging.
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PMC11502327
Nanostructured carriers deliver drugs mainly through active delivery and passive delivery, in which drugs integrate into the inner cavity of the nanostructure with the help of hydrophobic effect, and realize the transfer of drugs from high concentration to low concentration at specific targets, and then release a specific amount of drugs.
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PMC7961460
How this protein is secreted, recognized by fibroblasts and which possible intracellular pathways are involved in the modulation of HA synthesis is yet to be elucidated.
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PMC11718109
Moreover, either VGLUT2 (VGLUT2-GFP, Fig. 7A, B) or VGLUT1 (VGLUT1-GFP, Fig. 7C, D), when co-expressed with VMAT2 (VMAT2-FLAG), synaptophysin (untagged) and synapsin (mCherry-synapsin) showed selective preference of the glutamate transporters for the synaptophysin-synapsin condensates over the VMAT2-synapsin clusters.
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PMC7823217
Lee et al. developed 3D ovarian in vitro tumor model composed of epithelial ovarian cancer (EOC) cells, reporting a substantial transition in histological features of 3D constructs compared to 2D tumor models, which are hallmark features of primary tumors.
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PMC11441402
This study demonstrates that the digital microscopy automated cell imaging system is an effective method for assessing cell proliferation and the cytotoxic effect of compounds on both adherent and suspension cell lines.
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PMC11306331
4MBP-based condensate dissolution extends to FET family proteins.
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PMC8409415
CD70‐ADC significantly inhibited the proliferation of CD70‐expressing OvCA cells in vitro and in vivo and the tolerability of CD70‐ADC has been widely investigated in previous studies., , ,
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