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PMC9429973
Additionally, we analyzed the association of genomic aberrations with clinicopathological features in DLBCL.
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PMC9429973
Among the many factors that contribute to disease pathophysiology is stiffening and sickling of RBC, which is the direct result of the polymerization of abnormal hemoglobin S. Sickling is one of the core factors that cause vaso-occlusion and sickling is modulated by glycolytic intermediates such as 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP).
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PMC6160470
Relative ATPase activity after treatment of P-gp enriched vesicles with compounds DAC-2Amide and DAC-3Amide.
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PMC9429973
Median laboratory parameters were: WBC 15.5x10/L (range 1-348.8), Hgb 97g/L (range 20-166), Plt 53.5 (range 1-422), LDH 249U/L (1-4169).
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PMC11300085
These data suggested that chemerin might primarily exert a distinct role in different types of OC cells.
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PMC9429973
Results: We demonstrate that UCART20x22 displays strong activity against tumor cell lines expressing either a single antigen, CD20 or CD22, or both simultaneously.
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PMC11578343
Gold etchant (Gold Etchant TFA, Transene) was carefully pipetted onto the portion of electrodes to expose Pt in those areas that would make direct contact with the fluid in the channel.
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PMC7917457
The SW982 cell line was cultivated at 37°C in 100% air.
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PMC11534377
For fixation, cells were treated with 4% paraformaldehyde (PFA) for 10 minutes at room temperature.
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PMC11699042
Thus, we subjected 11 A-673 EwS strains (including two A-673 with genetic modifications, Fig. 1a), five HeLa cervical cancer strains, and five MCF-7 breast cancer strains to a drug screening consisting of a selection of 10 active compounds addressing non-redundant functional pathways, which encompassed the same drugs used in Ben-David et al. .
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PMC9118379
Furthermore, the differences in the identification results of SSe-cFDR and CMSe-cFDR are shown in Figure S5B and Table S4.
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PMC10502403
Sixty days after NE1-GMC infusion, peripheral blood was obtained from 3 mice, as shown in Figure 2A, and examined. (
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PMC9646302
The results suggested that LAPTM5 expression was higher in patients with ccRCC than that of patients in the control group (Figures 1(a)–1(e)).
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PMC9429973
Endothelial injury from COVID-19 triggers platelet activation and adhesion, leukocyte aggregation, cytokine storm and complement activation.
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PMC8316344
We also found that beta-transducin repeat containing E3 ubiqutin protein ligase (βTrCP) was a genuine E3 for the ubiquitination of TFRC, and TRIB2 was unable to decline labile iron level once upon βTrCP was knocked out.
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PMC10858941
Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis.
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PMC11397654
The Methyl Thiazolyl Tetrazolium (MTT) assay performed with MDA-MB-231 cancer cells revealed that, in contrast to the ligand itself, the copper(II) complex exhibited a high antiproliferative potency with an IC50 value of 165 nM. Its toxicity for the reference line was, however, not checked in the study.
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PMC11638255
Abbreviations: n.d.
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PMC11705630
Also recent studies revealed that GLDC promotes metastasis of colorectal cancer 14 and plays a crucial role in the progression of prostate cancer 15.
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PMC11594074
The cell pellet was fixed using 80% ethanol and kept at −20 °C for 48 h. Then, the cells were resuspended using 1 mL PBS enhanced with 1 mg/mL RNase A (Sigma-Aldrich), as well as 50 µg/mL propidium iodide (PI) (Sigma-Aldrich) and incubated in the dark at room temperature for 15 min.
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PMC10969097
CAFs are described as inherently resistant to docetaxel .
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PMC9370419
The pSBtet-GH was a gift from Prof. Eric Kowarz (Addgene 60498) .
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PMC4395774
The PGK promoter has now been used in the context of self-inactivating LV vectors in a clinical trial of HSC gene therapy for metachromatic leukodystrophy with considerable efficacy and may have advantages for other hematopoietic diseases.
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PMC11354225
First of all, A-431 cells exposed to EGCG at low concentrations (10 µM, 20 µM and 40 µM) for 4 h did not reduce their metabolic viability (MTT assay).
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PMC3734024
As determined by surface expression of B220, CD19, and IgM, we found that B cells comprised the majority (∼60%) of constitutively FasL splenocytes (Figures 1A and 1B).
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PMC9429973
Analysis of the overlap between these results identified 33 peaks increased at D37 in comparison to DMSO control and day 1 treatment samples.
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PMC11470381
Execute auto threshold by appending dark stack to the thresholding method, indicating that thresholding is performed on an image stack where the object of interest appears darker than the background.
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PMC11704135
The utilization of the pyrimidine derivatives as antioxidants and anti-inflammatory agents is just one of their many different applications.
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PMC11656657
Indeed, our in vitro studies demonstrated that CAR.GD2 T-cells effectively eradicated GD2-positive sarcoma cells.
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PMC9964654
For these studies, the IC50 values at shorter incubation times (3 h) were determined as part of a compromise to ensure that the compounds entered the cells and deposited measurable Au levels.
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PMC11297139
Importantly, the genes putatively activated by the upregulated cREs showed strong enrichment in the cancer-related GO terms compared to the other activated genes (Fig. 5e).
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PMC10723784
Following the addition of JC‐1, the cells were incubated for 10–30 min at 37°C.
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PMC7039683
Although periderm was not among the tissues evaluated by this project, top-scoring tiles were enriched within enhancers for several epithelial cell types more so than in other categories of enhancers (Figure 4A).
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PMC11463018
1 2 8 ∼ 129 °C.
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PMC11511922
Finally, the supplementary Figures S4B and S4D contain errors.
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PMC8526701
B Combination index (CI) and fraction affected of GSK602 and imatinib combining at different concentration in GIST-882 cells treated for 48 h were analyzed by the CompuSyn program (ComboSyn).
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PMC11047729
In the case of mRNA, this decrease was to 96, 69, 21, and 20% after 1, 2, 4, and 6 h, respectively, and when it came to the protein, to 97, 69, 21, and 20% after similar times.
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PMC11742047
In HL-60 cells, SM hydrolysis and Cer generation were shown to be involved in a signal transduction pathway that mediates the effects of tumor necrosis factor-α (TNF-α) and other agents on cell growth and differentiation.
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PMC11742670
They were incubated at 37 °C in a humidified environment containing 5% CO2.
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PMC10571053
Despite the recent proliferation of papers describing novel molecules that can induce ferroptosis, very few studies have addressed potential interactions with ABC transporters that might limit bioavailability or brain penetration.
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PMC9429973
Treatments that can reduce the need for blood transfusions and iron chelation therapy in this population would significantly lower this economic burden.
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PMC9792775
Therefore, the intention of this research was to assess whether LFU combined with PTX could act as a means of comprehensive treatment, for synergistically increasing the anti-tumor action of the drug and providing experimental framework for clinical management of sarcoma tumor.
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PMC8662250
Membranes were then incubated with the specific secondary antibodies conjugated to HRP.
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PMC11705862
Colocalization was also observed between IRIS-1 and IRIS-2 and the neuronal marker NeuN (visible as white puncta).
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PMC6182045
Dilutions were performed in blocking buffer (1% BSA in PBS) and all assays were performed in duplicate.
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PMC9429973
After a median follow up of 49 months (95% CI: 44-54), 59% of patients were alive.
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PMC10978090
The sample was considered low positive for HIT if suspension became not completely transparent with UFH 0.2 IU/mL and/or 0.5 IU/mL. The sample was considered negative for HIT if negative results were obtained with four donors.
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PMC11367146
Fig. 7 Intramolecular hydrogen bond analysis (A) apo-BCL2, BCL2-daucosterol and BCL2-gigantol (B) apo-ESR1, ESR1-daucosterol and ESR1-gigantol (C) apo-MMP9, MMP9-daucosterol and MMP9-gigantol complex.
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PMC11247842
BTA21: 62,941,833 (rs136844062) is an intronic variant of a non-coding RNA that is close to VRK1.
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PMC11612315
Although our results highlight exendin 20–29 as a promising candidate for developing safer peptide analgesics targeting TRPV1, the translation of these findings into clinical practice requires further investigation.
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PMC8735881
Taken together, the results suggested that CMI02 and CMI06 can efficiently modify human primary CD4 T cells with high resistance to HIV-1 infection and survival advantage.
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PMC8345486
The effect of compound 23 alone (40 μM) and in combination with cisplatin on ATP levels was also measured in cells grown in a monolayer for comparison (A2780, A2780cis, A2780R, SKOV-3, and OVCAR-3).
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PMC9429973
At baseline, 34 of them had a trough level of <1IU/dL and the number remained 10 at study exit.
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PMC9429973
M. López-Esteban, D. Carbonell, M. Bastos-Oreiro, I. de la Iglesia, A. Pérez-Corral, M. Chicano, P. Muñiz, L. Sanz-Villanueva, R. Bailén, G. Oarbeascoa, J. Anguita, M. Kwon, J. L. Díez-Martín, I. Buño, C. Martínez-Laperche Hospital General Universitario Gregorio Marañón; Instituto de Investigación Sanitaria Gregorio Marañón; Department of Medicine; Department of Cell Biology, Complutense University of Madrid; Genomics Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Background: Monitoring of CD19-targeted chimeric antigen receptor (CAR)-T cell levels is essential for an optimal follow-up of patients.
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PMC11697703
following manufacturer’s instructions, followed by qPCR 2 method, using U6 as control and the following primers for miR-193b and miR-365: mmu-365a specific primer: CG-TAATGCCCCTAAAAATCCTT mmu-miR-193b specific primer: CCCACAAAGTCCCGCTAAA Fezf2 shRNA sequence used: TTTAAATCCA-GTGCGCTGAAACATATTTAAT-TCCAGGCCTC Cloned into pAAV (Vector Builder).
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PMC11085211
In detail, we observed a significant increase in both early and late apoptosis compared to the control (31% vs. 15%; p < 0.0001 and 15% vs. 3%; p < 0.001, respectively).
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PMC7519871
1mM solution of cisplatin was prepared by initially dissolving it in dimethylformamide (DMF) followed by addition of milli Q (mQ) water (ration 1:5).
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PMC11342785
Here, we take advantage of TPPP’s minimal architecture and desirable features to develop synMAPs, engineered proteins that provide a regulatable platform for the assembly and synthetic exploration of higher-order MT structures in vitro and in living cells (Fig. 1A).
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PMC4369959
The in vitro (Table 1), in vivo (Table 2), and clinical effects (Table 3) of ginger have also been described.
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PMC11575040
After the cells were harvested at 24 h following transient transfection, they were washed with PBS; this process was followed by lysing with a lysis buffer (50 mM Tris–HCl at pH 8.0, 150 mM NaCl, 1% NP-40, 0.02% sodium azide, 1 μg/mL aprotinin, and 1 mM phenylmethylsulfonyl fluoride) at 4 °C for 30 min.
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PMC11585565
Expression levels of wild-type and mutant proteins at 24- and 48-hours post-transfection, with FLAG-tagged CNNM4 protein band intensities normalized to GAPDH.
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PMC6034753
An asterisk () indicates statistically significant difference (P < 0.05) between Apoptin and Meq-Apoptin or Meq transfected cells. (
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PMC8978939
To evidence the consequence of these intermediate levels of HIF-2α protein, we quantified mRNA levels of two of its downstream targets: VEGF-A and GLUT1 using qRT-PCR in normoxic and pseudohypoxic conditions ( Figure 2C ).
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PMC9219615
Data analysis was achieved via the flow cytometer’s Kaluza software (Beckman Coulter, Indianapolis, IN, USA).
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PMC11306019
Contrary to expectations, the number of VDMs did not directly correlate with their antagonistic potency (Table 1; Supplementary Figures S2, S3).
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PMC9429973
Plasma TNF and TGF concentrations were lower than in the low-NLR group, apparently due to lower blast content.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plasma", "TNF", "and", "TGF", "concentrations", "were", "lower", "than", "in", "the", "low-NLR", "group", ",", "apparently", "due", "to", "lower", "blast", "content", "." ] } ]
PMC10938377
This is in contrast to the other Au(i) compounds tested, AuDPPBX and auranofin, which both show significant cross-resistance with cisplatin.
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PMC11790599
Confocal images showing the location of Rab7 on macropinosomes after treatment of TSL (6.32 μΜ, 24 h) in ZR-75-1 expressing mCherry-Rab7 (40×, zoom 3).
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PMC10955424
IL-6 concentration in each of the ascites fluid tested was compared to its relative ability to confer RJY13 platinum resistance (D).Fig 2 Identification of soluble factors enriched in malignant and cirrhosis ascites.
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PMC11672617
In our investigation of mitochondrial potential dissociation, we employed the conventional oxidative phosphorylation dissociator, carbonyl cyanide m-chlorophenylhydrazone (CCCP), which is frequently utilized to induce the opening of transition pores and enhance mitochondrial membrane permeability to protons, ultimately leading to mitochondrial membrane potential dissipation (ΔΨm).
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PMC8389560
At the same time, it was shown that some of the Bcl-2 family proteins could interact with the IP3R at the ER .
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PMC11271800
The combination of anti-PD-1/PD-L1 antibody and imatinib has been found to enhance the anti-tumor effect of imatinib in a mouse GIST model.
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PMC7757104
The specific mechanism involves the modulation of the expression of transcription factors that contribute to EMT initiation, such as Twist, Snail and Slug (33).
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PMC9429973
Additionally, PET/CT findings at EOT were predictive of relapse, with a median PFS of 30 months in PETEOF (+) vs 88 months in PETEOT(-) (p = 0.005).
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PMC8481254
C Colony-formation assay of Bel-7402 and Bel-7404 cells treated with methanol or 40 μM CA.
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PMC10607604
Total RNA (1 μg) was reverse transcribed using 5 μM of random hexamers (Roche) and Superscript II, according to the manufacturer’s instructions (Invitrogen).
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PMC11727145
The results of H&E staining revealed better HaCaT proliferation and deeper dermal penetration for the DED stored at 4 °C compared to lower temperatures (Figure 2A–C).
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PMC11705862
IRIS-1 (G) and IRIS-2 (I) positive neurons in the CA1 regions was divided into low, intermediate or high AT8 immunoreactivity, where low represents healthy neurons (very low or no AT8 staining), and high represents neurons with high amount of AT8 immunoreactivity (each representative neuron is indicated with dotted rectangles, green for low, yellow for intermediate and red for high, n ≥ 30 neurons per case and n ≥ 10 neurons per AT8 immunoreactivity category was analyzed).
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PMC9581083
More investigation is needed to explore possible effects and underlying mechanisms of NRICM101, and to determine the optimal composition of herbal ingredients to maximize the effectiveness of this formula.
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PMC4443654
Striking examples include the strong influence of H3K9me3 in K562 leukemia cells, and EGR1 binding in H1 hESC.
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PMC11509224
The molecule, tedanol (221, Figure 17), was a brominated and sulfated pimarane diterpene isolated from the Caribbean sponge Tedania ignis .
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PMC6450504
The viability of the treated cells was compared to a nontreated control.
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PMC11724582
Morphology was observed under a microscope (magnification, ×40). (
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PMC11060216
Figure 2 displays information about squamous cell carcinoma marker expression, such as P40, CK5/6 and P63, in S100A6 overexpressed tumor tissues (Calu-6/S100A6 group) and the controls (Calu-6, Calu-6/neo).
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PMC6160470
Cell viability assay was performed as described previously.
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PMC9611901
Leather products are usually in close contact with the surface of human skin, which has specific properties and multiple protective barriers against potentially harmful exposures.
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PMC9424261
Images of all the immunoblots are representative of three independent experiments.
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PMC10747139
Molecular recognition of the hydrogen bonds further stabilized the Ru(II)–RNA-bound system through electrostatic attraction, which efficiently inhibited the Moloney murine leukemia virus (M-MuLV) and HIV-1 RTs.
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PMC11737091
This approach has the potential to bypass the limitations associated with direct CDC7 kinase inhibition, including the challenges mentioned above, and may lead to the development of more selective and potent anticancer therapies.
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PMC11371747
This protective effect of l-LV was dependent on cellular RFC expression as corroborated in RFC/PCFT-knockout and RFC/PCFT-transfected cells.
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PMC11739504
The graphs showed relative western blotting band intensity of Kat2b and acetylated-α-tubulin normalized each loading controls.
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PMC9429973
Summary/Conclusion: Combining MRD analysis with WGS studies carries the potential to reveal crucial information about sensitizing and resistance mutations and underlying cellular mechanisms.
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PMC11727062
Inhibiting this metabolic pathway can delay the development of resistance to BRAF inhibitors, thereby enhancing therapeutic outcomes in melanoma with BRAF mutations (Brummer et al. 2019).
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PMC11087766
All cells are representative of the population.
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PMC9429973
Dunkerque, Dunkerque; CH Cesson Sévigné, Cesson Sévigné; CH.
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PMC8735881
To this end, purified CD4 T cells were stimulated with anti-CD3/CD28-coated beads and then transduced with the CMI02 and CMI06 vectors.
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PMC9250505
Apoptotic cells refer to Annexin-V positive (early apoptosis) + Annexin-V and PI double-positive (late apoptosis) cells (n = 3).
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PMC11670407
Subsequently, the extracted RNA was reverse transcribed into cDNA using Hifair® III 1st Strand cDNA Synthesis SuperMix (YEASEN, 11141ES60, China), and the extracted RNA was subjected to RT-qPCR using Hieff® qPCR SYBR Green Master Mix (YEASEN, 11201ES03, China).
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PMC11594641
Based on our findings, we assume that Rab27A is not a universal regulator in the vesicular trafficking in all kinds of malignant cells.
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PMC11594588
Non-physiological Fe ion overload increases ROS production while significantly disrupting energy metabolism occurring in the myocardium.
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