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PMC11323699
CD4, CD8, CD68, CD163, and FoxP3 cells were assessed by immunofluorescence and scored as the number of positive cells.
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PMC11754784
White arrows indicate macrophages that phagocytized cancer cells.
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PMC11686380
Cells were co-transfected with pCAG-Turbo RFP together with pSuper-Luc (Control), pSuper-mGAP43#1 (KD#1), or #2 (KD#2) (1.0 µg each), and cultured for 72 h. Cells were stained with anti-GAP43.
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PMC11591052
Despite this small difference, it can be concluded that, in general, 20E affects myoblasts and fibroblasts in the same way, causing an increase in their energy metabolism.
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PMC11290772
The resulting ROBO1-NK cells were then monitored using flow cytometry with anti-CD3, anti-CD34, anti-CD16, and anti-CD45 antibodies (ab16669, ab81289, ab183354, and ab40763, Abcam, Cambridge, UK).
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PMC8567602
To test whether these two interact in BAF-family–sized complexes, we performed glycerol gradients to size the eluted complexes from the HA-IP.
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PMC8073654
Z. cassumunar was traditionally used to release pain in osteoarthritis and rheumatoid arthritis.
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PMC11672881
These results align with a study by El-Far et al., who found that the combination of TQ and CU significantly improved apoptosis in a breast cancer cell line compared to each drug alone .
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PMC11720107
Among all the studied cell lines, the Violeta cultivar had the least effect on cell metabolism.
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PMC11590005
Further research is needed to analyse the social dy-namics and anti-racist engagement in both private and public Brazilian dental education .
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PMC9429973
Five treatments were associated with an elevated creatinine, one of which was grade 2 and resolved to baseline following additional hydration.
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PMC10589262
Furthermore, leveraging the differential protein trafficking regulation between murine and human cells can be a valuable strategy for future studies in this field .
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PMC10772747
The objective of this study was to evaluate the potential and mechanisms of phytochemicals in Eleutherine bulbosa (EBE) in inducing apoptosis and inhibiting the cell cycle in breast cancer through a network pharmacology approach and in vitro validation.
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PMC11549062
Carotid plaques underwent fixation with 4% paraformaldehyde, followed by dehydration using gradient ethanol, transparency with xylene, and were embedded in paraffin.
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PMC11754291
The severe reduction in metabolic activity under UVA light, which served as a positive control, emphasizes the known cytotoxic effects of UVA due to reactive oxygen species (ROS) generation (Matsumura and Ananthaswamy, 2004).
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PMC10079526
Cell lineSpecificsMYC translocationBCL2 or 6 translocationp53 statusRef.
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PMC11727062
Artemisia annua, recognized as cold in nature and bitter and pungent in taste in TCM, is associated with the liver and gallbladder meridians.
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PMC9429973
A total of 168 adult patients with r/r DLBCL will be randomized in a 1:1 ratio to receive MB-CART2019.1 or SoC therapy.
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PMC11285179
Briefly, lung adenocarcinoma cells were cultured under two different oxygen concentrations, 1% and 20%, respectively.
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PMC10470467
Second, it can balance errors within unbalanced data sets (11).
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PMC9429973
Methods: We established drug-resistant clones (R) from parental ALL/SIL T-ALL cell line using a stepwise increase in treatment dose with TG.
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PMC9429973
As the score is intended for patients aged ≤70 years with PMF, the final analysis was carried out in 218 patients meeting these criteria.
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PMC5925824
Panel b: Gene expression analysis of cell lysate from the mixed leukocyte reactions was performed using QuantiGene Plex assay.
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PMC11806818
Breast cancer (BC) is one of the most serious diseases threatening women’s health, and circulating tumor cells are a reliable biomarker for non-invasive early breast cancer diagnosis.
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PMC11267830
Depletion of RBM39 leads to aberrant splicing events.
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PMC9429973
The effect of ara-C in monotherapy was also cell line dependent.
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PMC6160470
ABC transporters maintain the concentration of chemotherapeutics in cancer cells below cytotoxic levels.
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PMC9352806
All the lipid signals in the mode of positive and negative ion, identified as significant (VIP>1 and p<0.05), were depicted in Fig. 2C and D, as the heatmaps.
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PMC6650823
The effectiveness and benefits of synthetic small-molecular-weight compounds as potential anticancer drugs are currently under assessment.
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PMC9964654
The hydrodynamic diameters were below 100 nm, and the zeta potential values were indicative of high stability and a low tendency to form aggregates.
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PMC9429973
Regarding HMA therapy, the median time to treat was 2.4 months, 78.8% patients received AZA and 22.2% DAC, the median number of cycles of 7 (IQR 4-12) during a median period of 8.1 months (m).
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PMC11588008
First, the apoptosis rate in the model group was increased compared with that of the blank group.
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PMC11351758
To precisely control calcium concentrations, we used HEPES-buffered saline containing 140 mM of NaCl, 5.4 mM of KCl, 1.8 mM of CaCl2, 0.8 mM of MgCl2, 10 mM of glucose, and 10 mM of HEPES at pH 7.4.
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PMC9429973
Primary analysis of the CAPTIVATE Fixed Duration (FD) cohort demonstrated deep, durable responses with fixed-duration I+V (Ghia et al, ASCO 2021).
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PMC10197932
Briefly, the cells were resuspended at 5 x 105 cells/ml of PBS pH7.2 supplemented with 2% FCS then incubated for 20 min with 25 nM Mitotracker Red and 100 nM Mitotracker Green mix staining solution at 37°C or preincubated with 100 nM of ionophore Valinomycin 15 min before staining, as a positive control, were indicated.
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PMC11684269
Upon activation, the metabolic pathway of the T cell undergoes the transition from FAO to glycolysis to partially fuel the rapid metabolic demand for cell division, differentiation, and effector function, therefore the glycolytic pathways are regarded as major symbols for T cell activation (7, 8, 12, 19).
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PMC10589262
The involvement of membranous MT-KIT in downstream signaling was also investigated using 30N12, an inhibitor of trans-Golgi-to-PM trafficking .
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PMC10006224
It is also possible that the STAG2-CTCF interaction is outcompeted by WAPL binding more easily than the STAG1-CTCF interaction, particularly when the levels of CTCF are reduced, consistent with our previous proposal of differential affinities of STAG1 and STAG2 for CTCF and WAPL.
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PMC11564322
The mean values ± SD with *, **, and *** are statistically different from the control group at p < 0.05, p < 0.01, and p < 0.001, respectively.
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PMC11566417
The secretome from bovine adult mammary progenitor/stem cells, collected as conditioned medium (CM), has previously been shown to exhibit antimicrobial, regenerative (i.e. pro-migratory and angiogenic), and immunomodulatory properties in vitro .
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PMC11366496
WB assessed the RNF122 protein expression in glioma tissues of various grades (II–IV) and normal brain tissue (NBT).
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PMC9429973
Aims: Prognostic role of PET-CT performed before lymphodepletion and 1 month after CAR-T cell infusion, analyzed by qualitative and quantitative parameters Methods: We conducted an observational a prospective study on pts affected by R/R aggressive lymphomas receiving axicabtagene ciloleucel (axi-cel) or tisagenlecleucel (tisa-cel).
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PMC11591794
After cell viability rates were determined with the MTT method, the averages of the expression values obtained by qRT-PCR were determined by one-way ANOVA, and a significant difference was detected with the Tukey HSD test.
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PMC10674574
Table 1 presents selected experimental data on the permeability of model drugs with high, moderate, and low permeability.
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PMC5810978
Twenty seven HuNoV-positive stool samples [GII.1, n = 1; GII.2, n = 1; GII.3, n = 2; GII.4, n = 4 (2 New Orleans cluster and 2 Sydney cluster); GII.5, n = 1; GII.6, n = 2; GII.7, n = 2; GII.8, n = 1; GII.9, n = 1; GII.12, n = 2; GII.13, n = 2; GII.14, n = 2; GII.15, n = 2; GII.16, n = 2; and GII.17, n = 2] were provided by Dr. Jan Vinje at Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
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PMC11271278
N = 3 biological replicates.
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PMC10874773
lanceolatumLiu et al., 2020107Majusanol ANeuroprotectionI. lanceolatumLiu et al., 201910811-O-Debenzoyl-11α-O-2-methylcyclopent-1-EnecarboxyltashironinI. verumWang, Hu, Huang, & Qin, 2011109TashironinI. verumWang, Hu, Huang, & Qin, 2011110PseudomajucinI. majusFukuyama & Huang, 20051117-O-β-D-Glucoside pseudomajucinI. majusFukuyama & Huang, 20051127-O-MethylpseudomajucinI. minwanenseYokoyama et al., 20031132-O-n-ButyrylpseudomajucinI. merrillianumHuang, Yang, Takahashi, & Fukuyama, 200011414-O-β-D-GlucopyranosylpseudomajucinoneAntiviralI. jiadifengpiZhang et al., 2013115(6R)-PseudomajucinI. merrillianumFukuyama & Huang, 2005116(6R)-PseudomajucinoneI. merrillianumFukuyama & Huang, 2005117Dunnianolide CI.
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PMC10671321
The prolong Diamond antifade mountant (Invitrogen, Waltham, MA, USA) was used for mounting the cells.
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PMC5415764
Taken together, the co-delivery system demonstrated great promise as potential treatment for MDR-related tumors based on the synergistic effects of P-gp inhibition, enhanced endocytosis and intracellular sequentially drug release.
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PMC11087301
Conventionally, Wnt/β-catenin pathway has been considered as an EMT driver.
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PMC10823017
For ICA-1 combined with BYL719, the cytotoxicity was increased almost 20% compared to the BYL719 monotherapy.
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PMC9429973
Aims: We conducted this analysis to assess the safety and efficacy of zandelisib administered by ID as a single agent or in combination therapy in pts with R/R FL enrolled in a 3-arm phase 1b study in various B-cell malignancies.
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PMC7961460
Beads were boiled in 3× sample buffer for 5 min at 95 °C and centrifuged.
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PMC10222971
These cells are considered one among the widely used standards for non-tumoral human cells .
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PMC11790599
Female BALB/c athymic nude mice (4–6 weeks old) were subcutaneously injected with 2 × 10 of ZR-75–1 cells suspended in 100 μL of PBS into hind limb.
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PMC9429973
Bortezomib-containing regimens were received by 16 patients (41%).
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PMC8427838
The same membranes were blotted for GST or GAPDH Conserved RRKK motif mediates TMIGD1 binding with ERM proteins moesin and ezrin.
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PMC11769516
Zearalenone, fumonisins and trichothecenes (T-2 toxin, HT-2 toxin, DON, NIV, etc.)
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PMC9429973
Clinical activity will be characterized by ELN criteria (Dohner 2017).
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PMC11612508
Analytical grade compounds were used in the investigation precisely as obtained, without any further purification.
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PMC11787381
Eleven days after the surgery, mice were tested for long-term memory deficit in MWM test.
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PMC11719944
Additionally, PRL can function as a cytokine, influencing immune responses in various immune cell populations.
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PMC6337547
They possess various pharmacological activities, such as anti-cardiovascular , anti-oxidation , anti-inflammatory , and anti-tumour effects, and are widely distributed among Chinese Salvia species .
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PMC9672323
The effect of drugs on the proliferation of T cells in PBMCs in stimulated and non-stimulated conditions.
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PMC11644761
N. F6257; 1:300) and TRITC-conjugated anti-rabbit (Sigma-Aldrich, Saint Louis, Missouri, USA, Cat.
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PMC9919300
The cascade of events induced by lipid accumulation causes mitochondrial dysfunction and development of oxidative stress, which lead the disease from simple steatosis to more severe NAFLD stages.
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PMC9429973
Of these, 641 genes were commonly dysregulated in all T-LGLL subgroups, although a more marked dysregulation was observed in presence of STAT3 mutations.
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PMC10237474
By contrast, masses corresponding to proteins 5 and 6 with glycosylation were detected when purified from either GnTI cell lines (S5A and S5B Fig, HEK293S GnTI and Expi293F GnTI panels), confirming that GnTI cells expressed proteins with more homogeneous and less complex N-linked glycosylation.
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PMC9429973
MPNs patients receiving RUX therapy.
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PMC11337594
Cells were seeded in 6-well plates and stained in situ according to the instructions of the Annexin V-FITC/PI Apoptosis Detection Kit (C1062M#, Beyotime, Shanghai, China).
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PMC2011258
Despite diminished drug activity in the conjugate, assays designed to mimic antibody binding to tumour in which target cells were treated with conjugate and washed before culture, showed selective cytotoxicity for osteogenic sarcoma lines with little or no effect on non-cross reactive control cells.
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PMC10849234
Therefore, researchers have sought creative strategies to model human neutrophils for in vitro experiments, such as differentiating neutrophils in vitro from CD34+ hematopoietic stem cells (HSCs) [11–13], or from induced human pluripotent stems cells (iPSCs) .
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PMC10391797
CD123 and CLL-1 could be detected in THP-1 and MV411, but were not expressed in BALL-1 (figure 1B).
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PMC6642070
Maxim swimming capacity was measured as previously reported .
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PMC11594588
The principles of use of these drugs, the limitations associated with them, and above all, the phenomenon of resistance are currently the subject of very intensive experimental and clinical studies.
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PMC9429973
Twenty-eight pts had limited-stage (I-IIA) (LIM) and 20 had advanced-stage (IIB-IV) (ADV) disease.
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PMC9429973
CPX-351 is approved for newly diagnosed, therapy-related acute myeloid leukemia (AML) or AML with myelodysplasia-related changes in adults in Europe and patients aged ≥1 year in the United States who are candidates for intensive chemotherapy (IC).
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PMC11658074
b Quantification of skin elasticity in the control group and AT group.
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PMC11365427
However, phosphorylation of PERK–eIF2α did not activate ATF4.
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PMC11337594
Cells were treated with different doses (0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 µg/ml) of cisplatin or TER, and then assessed by MTT assay (n = 4). (
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PMC11786767
Our RO-3306 treatment efficiently reduced Ki-67 phosphorylation levels during mitosis (Fig. 8B).
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PMC11085211
AUN significantly impaired GIST cell viability, triggering a significant Annexin (+)/7-AAD (−) cell population, a marker of early apoptosis.
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PMC10589262
To mimic a constant ER stress condition in vivo, analysis was performed with or without TG, and imatinib was used as a control drug.
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PMC11653168
Stattic led to a dose-dependent decrease in tumor growth, with the highest dose generating the greatest antitumor effect.
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PMC9275501
At present, in order to maintain the optimal ratio of combined drug administration, the optimal ratio of the two drugs was first screened through in vitro cytotoxicity experiments and calculation of the combination index.
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PMC11790599
Additionally, tanshinlactone demonstrated effectiveness against lapatinib-resistant breast cancer cells, suggesting its potential as a therapeutic agent for overcoming drug resistance in cancer treatment.
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PMC5034105
All of these eight cell lines showed ZIKV-NS1 protein expression by IF, usually starting on 3 d.p.i.
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PMC9776316
Cancer cells with restored HR exhibit significant resistance to platinum drugs, underscoring the importance of HR in conferring cisplatin resistance .
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PMC11599565
The experiments with Fontana-Masson staining and TH expression alone were insufficient to conclusively classify these cells as neuronal.
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PMC10454535
Our data suggest that the combination treatment selectively inhibits MM cell growth in comparison to normal cells, which is vital in the consideration of potential MM drug treatments.
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PMC11574029
Tumor volume (B, E) and weight (C, F) were measured after 5 weeks.
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PMC9960565
Then, 10 µL of blood solution was added to a microtube, followed by 70 µL of compound solution (concentrations of 0.1, 1, and 5 µM).
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PMC11519567
SS18-EGFP and SS18-SSX1-EGFP proteins were overexpressed in BJ cells, respectively, and then planted at the bottom of a glass culture dish of about 0.16 mm.
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PMC10507284
Statistical tests: Cox regression analysis. (
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PMC11795610
They were then switched to KM-d medium containing 1.8 mM CaCl2 and incubated with or without different concentrations of myricetin.
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PMC9429973
Aims: To evaluate the safety and preliminary efficacy of epcoritamab + GemOx in pts with R/R DLBCL who are ineligible for ASCT.
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PMC9429973
One patient was diagnosed with disease progression in three months after termination of the therapy.
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PMC9429973
Randomization will be stratified by appropriateness for non-intensive vs intensive therapy, geographic region (US vs non-US sites), and age (<75 vs ≥75 years).
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PMC11454015
M.J. Sikora: None.
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PMC9454852
Therefore, csGRP78 acts as a death receptor for the secreted form, which as a self-ligand activates the apoptotic pathway leading to cell death .
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