OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11787651	1SWATH DIA scheme and LC gradients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1SWATH", "DIA", "scheme", "and", "LC", "gradients", "." ] } ]
PMC11612315	Three distinct fragments of exendin 9–39 were found to reduce CAP-induced inward currents and calcium influx through TRPV1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "distinct", "fragments", "of", "exendin", "9–39", "were", "found", "to", "reduce", "CAP-induced", "inward", "currents", "and", "calcium", "influx", "through", "TRPV1", "." ] } ]
PMC10818573	The recombinant plasmids were extracted using a TIAN Pure Midi Plasmid Kit from TIANGEN BIOTECH (Beijing, China) Co., Ltd., and the plasmid concentration was measured using a NanoDrop microvolume spectrophotometer from Thermo Fisher Scientific Inc. (Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "recombinant", "plasmids", "were", "extracted", "using", "a", "TIAN", "Pure", "Midi", "Plasmid", "Kit", "from", "TIANGEN", "BIOTECH", "(", "Beijing", ",", "China", ")", "Co.", ",", "Ltd.", ",", "and", "the", "plasmid", "concentration", "was", "measured", "using", "a", "NanoDrop", "microvolume", "spectrophotometer", "from", "Thermo", "Fisher", "Scientific", "Inc.", "(", "Waltham", ",", "MA", ",", "USA", ")", "." ] } ]
PMC10958426	Bar plot of percentage of pathways involved in cell-cell contact and secreted signaling in DEGCNV and DEGreg. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "plot", "of", "percentage", "of", "pathways", "involved", "in", "cell-cell", "contact", "and", "secreted", "signaling", "in", "DEGCNV", "and", "DEGreg", ".", "(" ] } ]
PMC11621493	Forty-eight hours after transfection cells were washed twice with PBS and harvested using a cell scraper.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Forty-eight", "hours", "after", "transfection", "cells", "were", "washed", "twice", "with", "PBS", "and", "harvested", "using", "a", "cell", "scraper", "." ] } ]
PMC11740399	For apoptosis analysis, T24 cells were seeded at a density of 2.5 × 10 cells per well in a 6-well plate and treated with control, 3025@ML, OXA, or a combination of both drugs for 48 h. Apoptotic cells were quantified using the Annexin V-APC/PI apoptosis kit (Elabscience, Houston, USA, catalog no. E-CK-A217) and a NovoCyte flow cytometer system (Agilent, Santa Clara, USA).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "apoptosis", "analysis", ",", "T24", "cells", "were", "seeded", "at", "a", "density", "of", "2.5", "×", "10", "cells", "per", "well", "in", "a", "6-well", "plate", "and", "treated", "with", "control", ",", "3025@ML", ",", "OXA", ",", "or", "a", "combination", "of", "both", "drugs", "for", "48", "h.", "Apoptotic", "cells", "were", "quantified", "using", "the", "Annexin", "V-APC/PI", "apoptosis", "kit", "(", "Elabscience", ",", "Houston", ",", "USA", ",", "catalog", "no.", "E-CK-A217", ")", "and", "a", "NovoCyte", "flow", "cytometer", "system", "(", "Agilent", ",", "Santa", "Clara", ",", "USA", ")", "." ] } ]
PMC11678368	Both the ν(Pd-Cl) and ν(Pd-N) stretching frequencies are higher in trans-[PdCl2(5ClL)2] compared to the 4ClL complex, signaling stronger Pd-Cl and Pd-N bonds, in the former compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "the", "ν(Pd-Cl", ")", "and", "ν(Pd-N", ")", "stretching", "frequencies", "are", "higher", "in", "trans-[PdCl2(5ClL)2", "]", "compared", "to", "the", "4ClL", "complex", ",", "signaling", "stronger", "Pd-Cl", "and", "Pd-N", "bonds", ",", "in", "the", "former", "compound", "." ] } ]
PMC11746948	Sample sizes: (c, g, h, j, l, m) n = 3 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sample", "sizes", ":", "(", "c", ",", "g", ",", "h", ",", "j", ",", "l", ",", "m", ")", "n", "=", "3", "independent", "experiments", "." ] } ]
PMC11643491	The images capture the particles before and after the stretching process within the film, along with their appearance post-recovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "images", "capture", "the", "particles", "before", "and", "after", "the", "stretching", "process", "within", "the", "film", ",", "along", "with", "their", "appearance", "post-recovery", "." ] } ]
PMC7039683	To our knowledge, no periderm cell line, from any species, exists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "our", "knowledge", ",", "no", "periderm", "cell", "line", ",", "from", "any", "species", ",", "exists", "." ] } ]
PMC11367939	F The colocalization of mRFP-Rab5 Q79L with synaptophysin-HA or with ATG9A-EGFP on the enlarged endosomes was analyzed using Pearson’s coefficients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "The", "colocalization", "of", "mRFP-Rab5", "Q79L", "with", "synaptophysin-HA", "or", "with", "ATG9A-EGFP", "on", "the", "enlarged", "endosomes", "was", "analyzed", "using", "Pearson", "’s", "coefficients", "." ] } ]
PMC8427838	Knockout of moesin in 786-0 cells inhibited basal acetylation (K40) of tubulin and, more importantly, markedly blocked TMIGD1-dependent acetylation of tubulin (Fig. 6A).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Knockout", "of", "moesin", "in", "786", "-", "0", "cells", "inhibited", "basal", "acetylation", "(", "K40", ")", "of", "tubulin", "and", ",", "more", "importantly", ",", "markedly", "blocked", "TMIGD1-dependent", "acetylation", "of", "tubulin", "(", "Fig.", "6A", ")", "." ] } ]
PMC9429973	ISS score was at 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "ISS", "score", "was", "at", "1", "." ] } ]
PMC10745221	With the changes observed in markers of the epithelial-to-mesenchymal transition (EMT) and reported association between PRMTs and EMT, we expected there to be variations in proteins with ADMA and SDMA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "changes", "observed", "in", "markers", "of", "the", "epithelial-to-mesenchymal", "transition", "(", "EMT", ")", "and", "reported", "association", "between", "PRMTs", "and", "EMT", ",", "we", "expected", "there", "to", "be", "variations", "in", "proteins", "with", "ADMA", "and", "SDMA", "." ] } ]
PMC11565047	These treatments activate the transcriptional functions of hormone receptors, either the estrogen receptor alpha (ERα) or the androgen receptor (AR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "treatments", "activate", "the", "transcriptional", "functions", "of", "hormone", "receptors", ",", "either", "the", "estrogen", "receptor", "alpha", "(", "ERα", ")", "or", "the", "androgen", "receptor", "(", "AR", ")", "." ] } ]
PMC6643347	Expression vectors for pseudovirus production were selected from the standard panel of HIV-1 reference strains (NIH AIDS Research and Reference Reagent Program; NIH ARRRP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "vectors", "for", "pseudovirus", "production", "were", "selected", "from", "the", "standard", "panel", "of", "HIV-1", "reference", "strains", "(", "NIH", "AIDS", "Research", "and", "Reference", "Reagent", "Program", ";", "NIH", "ARRRP", ")", "." ] } ]
PMC10932641	Reduced expression of lncRNA GPRC5D-AS1 activates the Wnt-β-catenin signaling pathway, promoting the occurrence and development of epithelial-mesenchymal transition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reduced", "expression", "of", "lncRNA", "GPRC5D-AS1", "activates", "the", "Wnt-β-catenin", "signaling", "pathway", ",", "promoting", "the", "occurrence", "and", "development", "of", "epithelial-mesenchymal", "transition", "." ] } ]
PMC9429973	Iron chelation therapy was received in 70.3% of TD patients (range, 44.4% in the UK and 92.6% in Germany) and in 45.8% of NTD patients (range, 37.0% in France to 80.0% in Canada).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Iron", "chelation", "therapy", "was", "received", "in", "70.3", "%", "of", "TD", "patients", "(", "range", ",", "44.4", "%", "in", "the", "UK", "and", "92.6", "%", "in", "Germany", ")", "and", "in", "45.8", "%", "of", "NTD", "patients", "(", "range", ",", "37.0", "%", "in", "France", "to", "80.0", "%", "in", "Canada", ")", "." ] } ]
PMC11612315	Our study identified a novel function for GLP-1-derived peptides in providing pain relief.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "identified", "a", "novel", "function", "for", "GLP-1-derived", "peptides", "in", "providing", "pain", "relief", "." ] } ]
PMC11093197	Our data suggest that the loss of RB1 in mammary epithelial cells results in a reduction of c‐Myc expression through alteration of MAPK activity and is concomitantly linked to metabolic remodeling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "suggest", "that", "the", "loss", "of", "RB1", "in", "mammary", "epithelial", "cells", "results", "in", "a", "reduction", "of", "c‐Myc", "expression", "through", "alteration", "of", "MAPK", "activity", "and", "is", "concomitantly", "linked", "to", "metabolic", "remodeling", "." ] } ]
PMC11653168	The protein expression levels were normalized to β-actin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "expression", "levels", "were", "normalized", "to", "β-actin", "." ] } ]
PMC11594588	This results an impairment of c-Jun-mediated signaling and COX-2 overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "results", "an", "impairment", "of", "c-Jun-mediated", "signaling", "and", "COX-2", "overexpression", "." ] } ]
PMC7582629	To accomplish global cell sensing that is effective for cancer diagnosis, the development of an automatic and objective method for discriminating cancer cells without any specialized knowledge of spectroscopy is needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "accomplish", "global", "cell", "sensing", "that", "is", "effective", "for", "cancer", "diagnosis", ",", "the", "development", "of", "an", "automatic", "and", "objective", "method", "for", "discriminating", "cancer", "cells", "without", "any", "specialized", "knowledge", "of", "spectroscopy", "is", "needed", "." ] } ]
PMC11683240	B, white blood cell count was determined in peripheral blood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "white", "blood", "cell", "count", "was", "determined", "in", "peripheral", "blood", "." ] } ]
PMC5308810	Taken together, our data strongly suggested that drug-induced CXCR4 plays significant roles in tumor progression. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "our", "data", "strongly", "suggested", "that", "drug-induced", "CXCR4", "plays", "significant", "roles", "in", "tumor", "progression", ".", "(" ] } ]
PMC11590870	Natural antioxidants are obtained from cereals, legumes, fruits, vegetables, etc.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Natural", "antioxidants", "are", "obtained", "from", "cereals", ",", "legumes", ",", "fruits", ",", "vegetables", ",", "etc", ".", "," ] } ]
PMC11791264	The levels of SETD7 knockdown were verified by real-time PCR and Western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "levels", "of", "SETD7", "knockdown", "were", "verified", "by", "real-time", "PCR", "and", "Western", "blot", "." ] } ]
PMC11144200	PEG (Sigma, USA) was then added, followed by it had been water-bathed at 37 °C for five minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PEG", "(", "Sigma", ",", "USA", ")", "was", "then", "added", ",", "followed", "by", "it", "had", "been", "water-bathed", "at", "37", "°", "C", "for", "five", "minutes", "." ] } ]
PMC10073922	Previous studies have shown that suppressing expression of NDRG2 by genetic and epigenetic methods led to development of a variety of tumors including lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "shown", "that", "suppressing", "expression", "of", "NDRG2", "by", "genetic", "and", "epigenetic", "methods", "led", "to", "development", "of", "a", "variety", "of", "tumors", "including", "lung", "cancer", "." ] } ]
PMC9587298	Product ions, except retrocyclization ions, observed in the MS spectra were noted by the corresponding aglycone number followed by an alphabetical letter in the order of the increasing mass to charge ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Product", "ions", ",", "except", "retrocyclization", "ions", ",", "observed", "in", "the", "MS", "spectra", "were", "noted", "by", "the", "corresponding", "aglycone", "number", "followed", "by", "an", "alphabetical", "letter", "in", "the", "order", "of", "the", "increasing", "mass", "to", "charge", "ratio", "." ] } ]
PMC9429973	In contrast, the presence of a resistance mutation led to discontinuation of current therapy or influenced future therapy selection in 9 out of 13 patients (69%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "presence", "of", "a", "resistance", "mutation", "led", "to", "discontinuation", "of", "current", "therapy", "or", "influenced", "future", "therapy", "selection", "in", "9", "out", "of", "13", "patients", "(", "69", "%", ")", "." ] } ]
PMC11628309	Nonetheless, like in all in vitro models, these studies have limitations and challenges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "like", "in", "all", "in", "vitro", "models", ",", "these", "studies", "have", "limitations", "and", "challenges", "." ] } ]
PMC9014716	PS-T increases the sensitivity of human hepatoma cells to OXA via the miR-224-5p/ABCB1/P-gp axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PS-T", "increases", "the", "sensitivity", "of", "human", "hepatoma", "cells", "to", "OXA", "via", "the", "miR-224", "-", "5p/ABCB1/P-gp", "axis", "." ] } ]
PMC11279598	These findings suggest that the pro-apoptotic effects of Manuka honey are not associated with the sugar content of Manuka, nor are the pro-apoptotic effects associated with Mesquite honey from a different region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "the", "pro-apoptotic", "effects", "of", "Manuka", "honey", "are", "not", "associated", "with", "the", "sugar", "content", "of", "Manuka", ",", "nor", "are", "the", "pro-apoptotic", "effects", "associated", "with", "Mesquite", "honey", "from", "a", "different", "region", "." ] } ]
PMC9429973	Results: 24 patients were included in our study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "24", "patients", "were", "included", "in", "our", "study", "." ] } ]
PMC11656380	Tat-mRam13 did not exhibit cytotoxicity in all these cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tat-mRam13", "did", "not", "exhibit", "cytotoxicity", "in", "all", "these", "cell", "lines", "." ] } ]
PMC11518702	HGAL, therefore, is paradoxically indicated to be not only a DLBCL driver but also, at elevated levels, a favorable prognostic indicator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HGAL", ",", "therefore", ",", "is", "paradoxically", "indicated", "to", "be", "not", "only", "a", "DLBCL", "driver", "but", "also", ",", "at", "elevated", "levels", ",", "a", "favorable", "prognostic", "indicator", "." ] } ]
PMC11317131	Several recent improvements to PE, including pegRNA engineering, optimized PE architecture, and twin prime editing have enabled the insertion of sequences >50 bp at high efficiencies (22,31–33).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "recent", "improvements", "to", "PE", ",", "including", "pegRNA", "engineering", ",", "optimized", "PE", "architecture", ",", "and", "twin", "prime", "editing", "have", "enabled", "the", "insertion", "of", "sequences", ">", "50", "bp", "at", "high", "efficiencies", "(", "22,31–33", ")", "." ] } ]
PMC11770746	Treatment with the 1:1 cisplatin+paclitaxel gave similar results to those obtained with cisplatin or paclitaxel, suggesting that the physical mixture was unable to minimize mechanical allodynia; withdrawal thresholds were in the range of 0.1–0.4 g compared with about 2 g for the untreated mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "the", "1:1", "cisplatin+paclitaxel", "gave", "similar", "results", "to", "those", "obtained", "with", "cisplatin", "or", "paclitaxel", ",", "suggesting", "that", "the", "physical", "mixture", "was", "unable", "to", "minimize", "mechanical", "allodynia", ";", "withdrawal", "thresholds", "were", "in", "the", "range", "of", "0.1–0.4", "g", "compared", "with", "about", "2", "g", "for", "the", "untreated", "mice", "." ] } ]
PMC11477621	H NMR (400 MHz, CDCl3) δ 9.09 (s, 1H), 7.68–7.62 (overlap, 2H), 7.18–7.13 (overlap, 2H), 6.97 (d, J = 4.1 Hz, 1H), 6.57 (t, J = 2.1 Hz, 1H), 6.03 (t, J = 3.3 Hz, 1H), 5.09–5.02 (m, 1H), 4.48 (t, J = 7.2 Hz, 2H), 4.03–3.95 (m, 1H), 3.65–3.59 (m, 1H), 3.03 (t, J = 7.2 Hz, 2H), 2.45 (s, 3H), 1.91–1.81 (overlap, 3H), 1.68–1.55 (overlap, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "NMR", "(", "400", "MHz", ",", "CDCl3", ")", "δ", "9.09", "(", "s", ",", "1H", ")", ",", "7.68–7.62", "(", "overlap", ",", "2H", ")", ",", "7.18–7.13", "(", "overlap", ",", "2H", ")", ",", "6.97", "(", "d", ",", "J", "=", "4.1", "Hz", ",", "1H", ")", ",", "6.57", "(", "t", ",", "J", "=", "2.1", "Hz", ",", "1H", ")", ",", "6.03", "(", "t", ",", "J", "=", "3.3", "Hz", ",", "1H", ")", ",", "5.09–5.02", "(", "m", ",", "1H", ")", ",", "4.48", "(", "t", ",", "J", "=", "7.2", "Hz", ",", "2H", ")", ",", "4.03–3.95", "(", "m", ",", "1H", ")", ",", "3.65–3.59", "(", "m", ",", "1H", ")", ",", "3.03", "(", "t", ",", "J", "=", "7.2", "Hz", ",", "2H", ")", ",", "2.45", "(", "s", ",", "3H", ")", ",", "1.91–1.81", "(", "overlap", ",", "3H", ")", ",", "1.68–1.55", "(", "overlap", ",", "3H", ")", "." ] } ]
PMC9429973	Med.	[ { "tags": [ "O", "O" ], "tokens": [ "Med", "." ] } ]
PMC11694066	More recently, pharmacologic manipulation of the cGAS–STING pathway has been proposed as a therapeutic strategy, notably in cancer to render tumors “immunologically hot” as a way to facilitate response to immunotherapies (44).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "recently", ",", "pharmacologic", "manipulation", "of", "the", "cGAS", "–", "STING", "pathway", "has", "been", "proposed", "as", "a", "therapeutic", "strategy", ",", "notably", "in", "cancer", "to", "render", "tumors", "“", "immunologically", "hot", "”", "as", "a", "way", "to", "facilitate", "response", "to", "immunotherapies", "(", "44", ")", "." ] } ]
PMC11745823	Furthermore, WB analysis was performed on different cohorts of glioma tissue samples, encompassing NBTs as well as gliomas classified as grades II, III and IV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "WB", "analysis", "was", "performed", "on", "different", "cohorts", "of", "glioma", "tissue", "samples", ",", "encompassing", "NBTs", "as", "well", "as", "gliomas", "classified", "as", "grades", "II", ",", "III", "and", "IV", "." ] } ]
PMC11502962	Weights of interactions in G2.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Weights", "of", "interactions", "in", "G2", "." ] } ]
PMC11750712	Notably, AUTO4 CAR T cells were not readily detected in PB but were detected at high levels in all post-treatment biopsy samples, including a patient treated with the lowest dose of 25 × 10 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "AUTO4", "CAR", "T", "cells", "were", "not", "readily", "detected", "in", "PB", "but", "were", "detected", "at", "high", "levels", "in", "all", "post-treatment", "biopsy", "samples", ",", "including", "a", "patient", "treated", "with", "the", "lowest", "dose", "of", "25", "×", "10", "cells", "." ] } ]
PMC11643361	Bis(pyrazol-1-yl)acetate complexes with silver(I) (35–37, Figure 5A) have also been investigated for their potential use as agents in anticancer treatment , using both 2D and 3D cell culture models of human colon cancer (HCT-15), pancreatic cancer (PSN-1), cervical cancer (A431), breast cancer (MDA-MB-231), ovarian cancer (2008), cisplatin-resistant ovarian adenocarcinoma (C13), and small-cell lung cancer (U1285) solid tumor cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bis(pyrazol-1-yl)acetate", "complexes", "with", "silver(I", ")", "(", "35–37", ",", "Figure", "5A", ")", "have", "also", "been", "investigated", "for", "their", "potential", "use", "as", "agents", "in", "anticancer", "treatment", ",", "using", "both", "2D", "and", "3D", "cell", "culture", "models", "of", "human", "colon", "cancer", "(", "HCT-15", ")", ",", "pancreatic", "cancer", "(", "PSN-1", ")", ",", "cervical", "cancer", "(", "A431", ")", ",", "breast", "cancer", "(", "MDA-MB-231", ")", ",", "ovarian", "cancer", "(", "2008", ")", ",", "cisplatin-resistant", "ovarian", "adenocarcinoma", "(", "C13", ")", ",", "and", "small-cell", "lung", "cancer", "(", "U1285", ")", "solid", "tumor", "cell", "lines", "." ] } ]
PMC11013014	The viability of both HL60 and HCT116 was measured for all the synthesised compounds at 1 μM final concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", "both", "HL60", "and", "HCT116", "was", "measured", "for", "all", "the", "synthesised", "compounds", "at", "1", "μM", "final", "concentration", "." ] } ]
PMC11687167	It might mediate inflammation and regulate other types of immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "might", "mediate", "inflammation", "and", "regulate", "other", "types", "of", "immune", "cells", "." ] } ]
PMC9429973	They are inherited in an autosomal recessive manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "are", "inherited", "in", "an", "autosomal", "recessive", "manner", "." ] } ]
PMC11011837	We also calculated the percentage of lipid classes among each cell line analyzed (see Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "calculated", "the", "percentage", "of", "lipid", "classes", "among", "each", "cell", "line", "analyzed", "(", "see", "Figure", "4", ")", "." ] } ]
PMC4270159	e. Incubate at room temperature for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e.", "Incubate", "at", "room", "temperature", "for", "5", "min", "." ] } ]
PMC9429973	The time to event endpoints will be analyzed based on the intent-to-treat population using a stratified log-rank test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "time", "to", "event", "endpoints", "will", "be", "analyzed", "based", "on", "the", "intent-to-treat", "population", "using", "a", "stratified", "log-rank", "test", "." ] } ]
PMC6114978	In silico studies have suggested that copy number changes (deletions) of genes upstream of the Hippo kinases (e.g. NF2) may result inactivation of TAZ and YAP , however the frequency of these genomic alterations is incompletely understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "silico", "studies", "have", "suggested", "that", "copy", "number", "changes", "(", "deletions", ")", "of", "genes", "upstream", "of", "the", "Hippo", "kinases", "(", "e.g.", "NF2", ")", "may", "result", "inactivation", "of", "TAZ", "and", "YAP", ",", "however", "the", "frequency", "of", "these", "genomic", "alterations", "is", "incompletely", "understood", "." ] } ]
PMC11700165	Both ITK-SYK- and BTK-SYK-encoding plasmids rendered BAF3 cells IL-3-independent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Both", "ITK-SYK-", "and", "BTK-SYK-encoding", "plasmids", "rendered", "BAF3", "cells", "IL-3-independent", "." ] } ]
PMC11767725	Therapeutic Studies: Relevant therapeutic studies were defined as those investigating microbiota-targeted interventions (e.g., probiotics, postbiotics, or phage therapy) and/or systemic treatments addressing underlying metabolic dysfunction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therapeutic", "Studies", ":", "Relevant", "therapeutic", "studies", "were", "defined", "as", "those", "investigating", "microbiota-targeted", "interventions", "(", "e.g.", ",", "probiotics", ",", "postbiotics", ",", "or", "phage", "therapy", ")", "and/or", "systemic", "treatments", "addressing", "underlying", "metabolic", "dysfunction", "." ] } ]
PMC11380454	of the binding of PD-L1 to PD-1 on both cell types increased cell viability and resistance to chemotherapy, while treatment with SAS significantly sensitized these cells to chemotherapy (Fig. 7A and.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "of", "the", "binding", "of", "PD-L1", "to", "PD-1", "on", "both", "cell", "types", "increased", "cell", "viability", "and", "resistance", "to", "chemotherapy", ",", "while", "treatment", "with", "SAS", "significantly", "sensitized", "these", "cells", "to", "chemotherapy", "(", "Fig.", "7A", "and", "." ] } ]
PMC11407042	Observe the cell adhesion under the inverted microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Observe", "the", "cell", "adhesion", "under", "the", "inverted", "microscope", "." ] } ]
PMC11459296	DAPI (62248,Thermo Fisher) was added for nuclear staining, and sections were mounted with Vectashield (H-1000-10, Vector Laboratories).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DAPI", "(", "62248,Thermo", "Fisher", ")", "was", "added", "for", "nuclear", "staining", ",", "and", "sections", "were", "mounted", "with", "Vectashield", "(", "H-1000", "-", "10", ",", "Vector", "Laboratories", ")", "." ] } ]
PMC9429973	Median age was 49.9 years (range 21–65).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "age", "was", "49.9", "years", "(", "range", "21–65", ")", "." ] } ]
PMC9429973	Glutaminase (GLS) is the initial enzyme in glutamine metabolism and glutaminolysis contributes to tumor growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glutaminase", "(", "GLS", ")", "is", "the", "initial", "enzyme", "in", "glutamine", "metabolism", "and", "glutaminolysis", "contributes", "to", "tumor", "growth", "." ] } ]
PMC10772747	Statistical analysis demonstrates that EBE treatment significantly differs from the control group in terms of the number of cells undergoing apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "demonstrates", "that", "EBE", "treatment", "significantly", "differs", "from", "the", "control", "group", "in", "terms", "of", "the", "number", "of", "cells", "undergoing", "apoptosis", "." ] } ]
PMC9428827	Mice were treated i.p.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "were", "treated", "i.p", "." ] } ]
PMC11634794	These findings suggest that LAMP1 may primarily function in the late stages of autophagy and might not be involved in its initiation or fusion between autophagosomes and lysosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "LAMP1", "may", "primarily", "function", "in", "the", "late", "stages", "of", "autophagy", "and", "might", "not", "be", "involved", "in", "its", "initiation", "or", "fusion", "between", "autophagosomes", "and", "lysosomes", "." ] } ]
PMC10094992	Quantification of malondialdehyde in samples was performed by using the calibration curve obtained by analysis of malondialdehyde tetrabutylammonium standard solutions in the range 10–1000 nM derivatized with DCHD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "malondialdehyde", "in", "samples", "was", "performed", "by", "using", "the", "calibration", "curve", "obtained", "by", "analysis", "of", "malondialdehyde", "tetrabutylammonium", "standard", "solutions", "in", "the", "range", "10–1000", "nM", "derivatized", "with", "DCHD", "." ] } ]
PMC9429973	L. J. Nastoupil, S. O’Brien, H. E. Holmes, L. Dsouza, D. Hart, E. Matsuda, T. Satterfield-Ledbetter, J. Skoble, E. Garner, M. Bryan, S. Kanner, E. Li, C. T. Thomas, J. Essell Lymphoma/Myeloma, UT MD Anderson Cancer Center, Houston; Department of Hematology and Oncology, University of California Irvine, Irvine; Oncology, Texas Oncology/Baylor Sammons Cancer Center, Dallas; Research, Oncology Hematology Care, Cincinnati; UCI Cancer Center, University of California Irvine, Irvine; Clinical Oncology Research Coordination, Baylor Research Institution, Dallas; Technical Operations; T Cell Therapeutics; Program Management/Operations; R&D, Caribou Biosciences, Inc., Berkeley; EffectStats LLC, Cambridge; Clinical Development, Caribou Biosciences, Inc., Berkeley; Blood Cancer, Oncology Hematology Care, Cincinnati, United States of America Background: Autologous CAR-T cell therapies have shown significant benefit in the treatment of patients (pts) with relapsed/refractory B cell NHL (r/r B-NHL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L.", "J.", "Nastoupil", ",", "S.", "O’Brien", ",", "H.", "E.", "Holmes", ",", "L.", "Dsouza", ",", "D.", "Hart", ",", "E.", "Matsuda", ",", "T.", "Satterfield-Ledbetter", ",", "J.", "Skoble", ",", "E.", "Garner", ",", "M.", "Bryan", ",", "S.", "Kanner", ",", "E.", "Li", ",", "C.", "T.", "Thomas", ",", "J.", "Essell", "Lymphoma/Myeloma", ",", "UT", "MD", "Anderson", "Cancer", "Center", ",", "Houston", ";", "Department", "of", "Hematology", "and", "Oncology", ",", "University", "of", "California", "Irvine", ",", "Irvine", ";", "Oncology", ",", "Texas", "Oncology/Baylor", "Sammons", "Cancer", "Center", ",", "Dallas", ";", "Research", ",", "Oncology", "Hematology", "Care", ",", "Cincinnati", ";", "UCI", "Cancer", "Center", ",", "University", "of", "California", "Irvine", ",", "Irvine", ";", "Clinical", "Oncology", "Research", "Coordination", ",", "Baylor", "Research", "Institution", ",", "Dallas", ";", "Technical", "Operations", ";", "T", "Cell", "Therapeutics", ";", "Program", "Management/Operations", ";", "R&D", ",", "Caribou", "Biosciences", ",", "Inc.", ",", "Berkeley", ";", "EffectStats", "LLC", ",", "Cambridge", ";", "Clinical", "Development", ",", "Caribou", "Biosciences", ",", "Inc.", ",", "Berkeley", ";", "Blood", "Cancer", ",", "Oncology", "Hematology", "Care", ",", "Cincinnati", ",", "United", "States", "of", "America", "Background", ":", "Autologous", "CAR-T", "cell", "therapies", "have", "shown", "significant", "benefit", "in", "the", "treatment", "of", "patients", "(", "pts", ")", "with", "relapsed/refractory", "B", "cell", "NHL", "(", "r/r", "B-NHL", ")", "." ] } ]
PMC11279397	Furthermore, β-sitosterol displayed great antiviral potential against avian and human IAVs in vitro .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "β-sitosterol", "displayed", "great", "antiviral", "potential", "against", "avian", "and", "human", "IAVs", "in", "vitro", "." ] } ]
PMC11519077	Our data showed that NOD1 was expressed significantly higher in the IL-1β-induced Caco-2 group compared to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "showed", "that", "NOD1", "was", "expressed", "significantly", "higher", "in", "the", "IL-1β-induced", "Caco-2", "group", "compared", "to", "the", "control", "group", "." ] } ]
PMC11406030	Our results showed that treatment with LMTK3 protein significantly induces integrin αV/β1 levels in a dose-response manner in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "showed", "that", "treatment", "with", "LMTK3", "protein", "significantly", "induces", "integrin", "αV/β1", "levels", "in", "a", "dose-response", "manner", "in", "ovarian", "cancer", "cells", "." ] } ]
PMC11593713	It is known that patients with SARS-CoV-2 infection who presented decreased TAC serum levels were more prone to disease exacerbation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "known", "that", "patients", "with", "SARS-CoV-2", "infection", "who", "presented", "decreased", "TAC", "serum", "levels", "were", "more", "prone", "to", "disease", "exacerbation", "." ] } ]
PMC11742431	The 0 h as a control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "0", "h", "as", "a", "control", ".", "(" ] } ]
PMC11257988	This provides a feasible strategy for targeting RTK for cancer treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "provides", "a", "feasible", "strategy", "for", "targeting", "RTK", "for", "cancer", "treatment", "." ] } ]
PMC11474209	Since they can probe surface coatings utilizing a variety of optical phenomena while attaining low impedance and high sensitivity, optical sensors have a good deal of opportunity in this area.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "they", "can", "probe", "surface", "coatings", "utilizing", "a", "variety", "of", "optical", "phenomena", "while", "attaining", "low", "impedance", "and", "high", "sensitivity", ",", "optical", "sensors", "have", "a", "good", "deal", "of", "opportunity", "in", "this", "area", "." ] } ]
PMC9429973	Methods: Clinical data were obtained from 2551 NDMM patients, followed up for ≥ 36 months or having died or progressed within 36 months post treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Clinical", "data", "were", "obtained", "from", "2551", "NDMM", "patients", ",", "followed", "up", "for", "≥", "36", "months", "or", "having", "died", "or", "progressed", "within", "36", "months", "post", "treatment", "." ] } ]
PMC9100622	The cells were treated with 0.5 µM (A673), 2.6 µM (TC71), and 2.4 µM (POE) Atorvastatin for 72 h. The implication of the mevalonate pathway in the cytotoxic effects of statins on Ewing cell lines and PDX-dissociated cells was assessed by rescue experiments performed by the addition of intermediate products of lipid/cholesterol synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "treated", "with", "0.5", "µM", "(", "A673", ")", ",", "2.6", "µM", "(", "TC71", ")", ",", "and", "2.4", "µM", "(", "POE", ")", "Atorvastatin", "for", "72", "h.", "The", "implication", "of", "the", "mevalonate", "pathway", "in", "the", "cytotoxic", "effects", "of", "statins", "on", "Ewing", "cell", "lines", "and", "PDX-dissociated", "cells", "was", "assessed", "by", "rescue", "experiments", "performed", "by", "the", "addition", "of", "intermediate", "products", "of", "lipid/cholesterol", "synthesis", "." ] } ]
PMC9429973	The mean levels of selected hemolytic markers (including bilirubin, LDH, reticulocytes), were decreased compared to baseline at the last available on-treatment time point, returning towards baseline 9 weeks after the last sutimlimab dose (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "levels", "of", "selected", "hemolytic", "markers", "(", "including", "bilirubin", ",", "LDH", ",", "reticulocytes", ")", ",", "were", "decreased", "compared", "to", "baseline", "at", "the", "last", "available", "on-treatment", "time", "point", ",", "returning", "towards", "baseline", "9", "weeks", "after", "the", "last", "sutimlimab", "dose", "(", "Figure", "1", ")", "." ] } ]
PMC6835428	PVTC was used as it contains positively charged amino groups, which allow siRNA binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PVTC", "was", "used", "as", "it", "contains", "positively", "charged", "amino", "groups", ",", "which", "allow", "siRNA", "binding", "." ] } ]
PMC9429973	Pts attaining a complete or partial response received maintenance with the same antibody every 2 months for 2 years or until disease progression (PD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "attaining", "a", "complete", "or", "partial", "response", "received", "maintenance", "with", "the", "same", "antibody", "every", "2", "months", "for", "2", "years", "or", "until", "disease", "progression", "(", "PD", ")", "." ] } ]
PMC11496728	Fig. 5Effect of Apaf1 knockout on apoptosis. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5Effect", "of", "Apaf1", "knockout", "on", "apoptosis", ".", "(" ] } ]
PMC9429973	The primary endpoint of the study was progression-free survival (PFS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoint", "of", "the", "study", "was", "progression-free", "survival", "(", "PFS", ")", "." ] } ]
PMC9429973	Most GI AEs were grade (G) 1/2 (including nausea, vomiting, and diarrhea) and there were no Tx-related G3/4 GI AEs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "GI", "AEs", "were", "grade", "(", "G", ")", "1/2", "(", "including", "nausea", ",", "vomiting", ",", "and", "diarrhea", ")", "and", "there", "were", "no", "Tx-related", "G3/4", "GI", "AEs", "." ] } ]
PMC4270159	Two studies published around the same time as the work of Wilson and colleagues also support the proposed mechanism of acquired resistance to RTK inhibition by signaling from the tumor microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "studies", "published", "around", "the", "same", "time", "as", "the", "work", "of", "Wilson", "and", "colleagues", "also", "support", "the", "proposed", "mechanism", "of", "acquired", "resistance", "to", "RTK", "inhibition", "by", "signaling", "from", "the", "tumor", "microenvironment", "." ] } ]
PMC11413393	Overall, MS023 treatment appears to induce a cytostatic phenotype that precedes cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "MS023", "treatment", "appears", "to", "induce", "a", "cytostatic", "phenotype", "that", "precedes", "cell", "death", "." ] } ]
PMC9429973	Innate immune system is the first line of defense against microbial pathogens, while at the same time it is the orchestrator of adaptive immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Innate", "immune", "system", "is", "the", "first", "line", "of", "defense", "against", "microbial", "pathogens", ",", "while", "at", "the", "same", "time", "it", "is", "the", "orchestrator", "of", "adaptive", "immunity", "." ] } ]
PMC10213199	The in vivo experiments revealed 74 upregulated genes in the low-concentration group, and CG13078 was a commonly downregulated differential gene, which is involved in ascorbate iron reductase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "in", "vivo", "experiments", "revealed", "74", "upregulated", "genes", "in", "the", "low-concentration", "group", ",", "and", "CG13078", "was", "a", "commonly", "downregulated", "differential", "gene", ",", "which", "is", "involved", "in", "ascorbate", "iron", "reductase", "activity", "." ] } ]
PMC5330095	Dr. Lowe is currently an adjunct Professor at the University of Maryland School of Medicine as well as the founder of three biotech companies and the Bio-Tech R&D Institute, Kingston Jamaica, all focusing on drug discovery and development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dr.", "Lowe", "is", "currently", "an", "adjunct", "Professor", "at", "the", "University", "of", "Maryland", "School", "of", "Medicine", "as", "well", "as", "the", "founder", "of", "three", "biotech", "companies", "and", "the", "Bio-Tech", "R&D", "Institute", ",", "Kingston", "Jamaica", ",", "all", "focusing", "on", "drug", "discovery", "and", "development", "." ] } ]
PMC11470381	Wash transfected Jurkat cells twice in 1× PBS at 165× g for 3 min.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wash", "transfected", "Jurkat", "cells", "twice", "in", "1", "×", "PBS", "at", "165", "×", "g", "for", "3", "min", "." ] } ]
PMC11721295	We quantified percentage positive as all staining above a specified threshold over the total area of the image.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "quantified", "percentage", "positive", "as", "all", "staining", "above", "a", "specified", "threshold", "over", "the", "total", "area", "of", "the", "image", "." ] } ]
PMC9429973	21-83yo).	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "21", "-", "83yo", ")", "." ] } ]
PMC9429973	Clinical management includes red blood cell (RBC) transfusions and splenectomy, which only partially improves anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "management", "includes", "red", "blood", "cell", "(", "RBC", ")", "transfusions", "and", "splenectomy", ",", "which", "only", "partially", "improves", "anemia", "." ] } ]
PMC9429973	At a median follow-up of 43 months, ZANU was associated with a higher VGPR+CR rate and demonstrated clinically meaningful advantages in long-term safety and tolerability vs IBR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "a", "median", "follow-up", "of", "43", "months", ",", "ZANU", "was", "associated", "with", "a", "higher", "VGPR+CR", "rate", "and", "demonstrated", "clinically", "meaningful", "advantages", "in", "long-term", "safety", "and", "tolerability", "vs", "IBR", "." ] } ]
PMC7757104	The optical density at 570 nm was determined using a SpectraMax 190 microplate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optical", "density", "at", "570", "nm", "was", "determined", "using", "a", "SpectraMax", "190", "microplate", "reader", "." ] } ]
PMC11055323	The underlying principle for these condensates formation is multivalent macromolecular interactions, like DNA/RNA molecules and proteins composed of multiple interaction domains and/or intrinsically disordered regions (IDRs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "underlying", "principle", "for", "these", "condensates", "formation", "is", "multivalent", "macromolecular", "interactions", ",", "like", "DNA/RNA", "molecules", "and", "proteins", "composed", "of", "multiple", "interaction", "domains", "and/or", "intrinsically", "disordered", "regions", "(", "IDRs", ")", "." ] } ]
PMC11224020	i, Box plot with minimum to maximum range of mean speed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "i", ",", "Box", "plot", "with", "minimum", "to", "maximum", "range", "of", "mean", "speed", "." ] } ]
PMC11590005	Values in bold indicate statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "in", "bold", "indicate", "statistically", "significant", "difference", "." ] } ]
PMC11536589	We also identified that the β-catenin/Tcf4 complex regulates the expression of MGST1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "identified", "that", "the", "β-catenin/Tcf4", "complex", "regulates", "the", "expression", "of", "MGST1", "." ] } ]
PMC11621493	The most prominent effect of PLA2G4D overexpression on cellular acylglycerol levels in COS7 cells was observed upon MAG supplementation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "prominent", "effect", "of", "PLA2G4D", "overexpression", "on", "cellular", "acylglycerol", "levels", "in", "COS7", "cells", "was", "observed", "upon", "MAG", "supplementation", "." ] } ]
PMC11790599	This indicates a dysfunctional macropinocytotic process that fails to properly fuse with the lysosomal system for subsequent hydrolysis or undergo recycling to the plasma membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "a", "dysfunctional", "macropinocytotic", "process", "that", "fails", "to", "properly", "fuse", "with", "the", "lysosomal", "system", "for", "subsequent", "hydrolysis", "or", "undergo", "recycling", "to", "the", "plasma", "membrane", "." ] } ]
PMC9429973	TOM-1, RS4;11 and REH presented LIP levels higher than the untreated condition, still no significant differences were noticed between the concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TOM-1", ",", "RS4;11", "and", "REH", "presented", "LIP", "levels", "higher", "than", "the", "untreated", "condition", ",", "still", "no", "significant", "differences", "were", "noticed", "between", "the", "concentrations", "." ] } ]
PMC11575040	Subsequently, the lysates were collected and centrifuged to remove cell debris, and protein assays were conducted using a Bio-Rad Protein Assay kit through a Bradford dye-binding procedure (Bio-Rad Laboratories, Hercules, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "lysates", "were", "collected", "and", "centrifuged", "to", "remove", "cell", "debris", ",", "and", "protein", "assays", "were", "conducted", "using", "a", "Bio-Rad", "Protein", "Assay", "kit", "through", "a", "Bradford", "dye-binding", "procedure", "(", "Bio-Rad", "Laboratories", ",", "Hercules", ",", "CA", ",", "USA", ")", "." ] } ]
PMC9429973	Three pts (25.0%) had low-grade CRS (by Lee, 2014; Grade 1, n=2; Grade 2, n=1) and there were no Grade 3–4 CRS events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "pts", "(", "25.0", "%", ")", "had", "low-grade", "CRS", "(", "by", "Lee", ",", "2014", ";", "Grade", "1", ",", "n=2", ";", "Grade", "2", ",", "n=1", ")", "and", "there", "were", "no", "Grade", "3–4", "CRS", "events", "." ] } ]

PMC11787651

1SWATH DIA scheme and LC gradients.

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PMC11612315

Three distinct fragments of exendin 9–39 were found to reduce CAP-induced inward currents and calcium influx through TRPV1.

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PMC10818573

The recombinant plasmids were extracted using a TIAN Pure Midi Plasmid Kit from TIANGEN BIOTECH (Beijing, China) Co., Ltd., and the plasmid concentration was measured using a NanoDrop microvolume spectrophotometer from Thermo Fisher Scientific Inc. (Waltham, MA, USA).

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PMC10958426

Bar plot of percentage of pathways involved in cell-cell contact and secreted signaling in DEGCNV and DEGreg. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "plot", "of", "percentage", "of", "pathways", "involved", "in", "cell-cell", "contact", "and", "secreted", "signaling", "in", "DEGCNV", "and", "DEGreg", ".", "(" ] } ]

PMC11621493

Forty-eight hours after transfection cells were washed twice with PBS and harvested using a cell scraper.

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PMC11740399

For apoptosis analysis, T24 cells were seeded at a density of 2.5 × 10 cells per well in a 6-well plate and treated with control, 3025@ML, OXA, or a combination of both drugs for 48 h. Apoptotic cells were quantified using the Annexin V-APC/PI apoptosis kit (Elabscience, Houston, USA, catalog no. E-CK-A217) and a NovoCyte flow cytometer system (Agilent, Santa Clara, USA).

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PMC11678368

Both the ν(Pd-Cl) and ν(Pd-N) stretching frequencies are higher in trans-[PdCl2(5ClL)2] compared to the 4ClL complex, signaling stronger Pd-Cl and Pd-N bonds, in the former compound.

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PMC11746948

Sample sizes: (c, g, h, j, l, m) n = 3 independent experiments.

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PMC11643491

The images capture the particles before and after the stretching process within the film, along with their appearance post-recovery.

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PMC7039683

To our knowledge, no periderm cell line, from any species, exists.

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PMC11367939

F The colocalization of mRFP-Rab5 Q79L with synaptophysin-HA or with ATG9A-EGFP on the enlarged endosomes was analyzed using Pearson’s coefficients.

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PMC8427838

Knockout of moesin in 786-0 cells inhibited basal acetylation (K40) of tubulin and, more importantly, markedly blocked TMIGD1-dependent acetylation of tubulin (Fig. 6A).

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PMC9429973

ISS score was at 1.

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PMC10745221

With the changes observed in markers of the epithelial-to-mesenchymal transition (EMT) and reported association between PRMTs and EMT, we expected there to be variations in proteins with ADMA and SDMA .

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PMC11565047

These treatments activate the transcriptional functions of hormone receptors, either the estrogen receptor alpha (ERα) or the androgen receptor (AR).

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PMC6643347

Expression vectors for pseudovirus production were selected from the standard panel of HIV-1 reference strains (NIH AIDS Research and Reference Reagent Program; NIH ARRRP).

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PMC10932641

Reduced expression of lncRNA GPRC5D-AS1 activates the Wnt-β-catenin signaling pathway, promoting the occurrence and development of epithelial-mesenchymal transition.

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PMC9429973

Iron chelation therapy was received in 70.3% of TD patients (range, 44.4% in the UK and 92.6% in Germany) and in 45.8% of NTD patients (range, 37.0% in France to 80.0% in Canada).

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PMC11612315

Our study identified a novel function for GLP-1-derived peptides in providing pain relief.

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PMC11093197

Our data suggest that the loss of RB1 in mammary epithelial cells results in a reduction of c‐Myc expression through alteration of MAPK activity and is concomitantly linked to metabolic remodeling.

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PMC11653168

The protein expression levels were normalized to β-actin.

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PMC11594588

This results an impairment of c-Jun-mediated signaling and COX-2 overexpression.

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PMC7582629

To accomplish global cell sensing that is effective for cancer diagnosis, the development of an automatic and objective method for discriminating cancer cells without any specialized knowledge of spectroscopy is needed.

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PMC11683240

B, white blood cell count was determined in peripheral blood.

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PMC5308810

Taken together, our data strongly suggested that drug-induced CXCR4 plays significant roles in tumor progression. (

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PMC11590870

Natural antioxidants are obtained from cereals, legumes, fruits, vegetables, etc.,

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PMC11791264

The levels of SETD7 knockdown were verified by real-time PCR and Western blot.

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PMC11144200

PEG (Sigma, USA) was then added, followed by it had been water-bathed at 37 °C for five minutes.

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PMC10073922

Previous studies have shown that suppressing expression of NDRG2 by genetic and epigenetic methods led to development of a variety of tumors including lung cancer.

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PMC9587298

Product ions, except retrocyclization ions, observed in the MS spectra were noted by the corresponding aglycone number followed by an alphabetical letter in the order of the increasing mass to charge ratio.

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PMC9429973

In contrast, the presence of a resistance mutation led to discontinuation of current therapy or influenced future therapy selection in 9 out of 13 patients (69%).

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PMC11628309

Nonetheless, like in all in vitro models, these studies have limitations and challenges.

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PMC9014716

PS-T increases the sensitivity of human hepatoma cells to OXA via the miR-224-5p/ABCB1/P-gp axis.

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PMC11279598

These findings suggest that the pro-apoptotic effects of Manuka honey are not associated with the sugar content of Manuka, nor are the pro-apoptotic effects associated with Mesquite honey from a different region.

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PMC9429973

Results: 24 patients were included in our study.

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PMC11656380

Tat-mRam13 did not exhibit cytotoxicity in all these cell lines.

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PMC11518702

HGAL, therefore, is paradoxically indicated to be not only a DLBCL driver but also, at elevated levels, a favorable prognostic indicator.

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PMC11317131

Several recent improvements to PE, including pegRNA engineering, optimized PE architecture, and twin prime editing have enabled the insertion of sequences >50 bp at high efficiencies (22,31–33).

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PMC11770746

Treatment with the 1:1 cisplatin+paclitaxel gave similar results to those obtained with cisplatin or paclitaxel, suggesting that the physical mixture was unable to minimize mechanical allodynia; withdrawal thresholds were in the range of 0.1–0.4 g compared with about 2 g for the untreated mice.

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PMC11477621

H NMR (400 MHz, CDCl3) δ 9.09 (s, 1H), 7.68–7.62 (overlap, 2H), 7.18–7.13 (overlap, 2H), 6.97 (d, J = 4.1 Hz, 1H), 6.57 (t, J = 2.1 Hz, 1H), 6.03 (t, J = 3.3 Hz, 1H), 5.09–5.02 (m, 1H), 4.48 (t, J = 7.2 Hz, 2H), 4.03–3.95 (m, 1H), 3.65–3.59 (m, 1H), 3.03 (t, J = 7.2 Hz, 2H), 2.45 (s, 3H), 1.91–1.81 (overlap, 3H), 1.68–1.55 (overlap, 3H).

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PMC9429973

Med.

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PMC11694066

More recently, pharmacologic manipulation of the cGAS–STING pathway has been proposed as a therapeutic strategy, notably in cancer to render tumors “immunologically hot” as a way to facilitate response to immunotherapies (44).

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PMC11745823

Furthermore, WB analysis was performed on different cohorts of glioma tissue samples, encompassing NBTs as well as gliomas classified as grades II, III and IV.

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PMC11502962

Weights of interactions in G2.

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PMC11750712

Notably, AUTO4 CAR T cells were not readily detected in PB but were detected at high levels in all post-treatment biopsy samples, including a patient treated with the lowest dose of 25 × 10 cells.

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PMC11643361

Bis(pyrazol-1-yl)acetate complexes with silver(I) (35–37, Figure 5A) have also been investigated for their potential use as agents in anticancer treatment , using both 2D and 3D cell culture models of human colon cancer (HCT-15), pancreatic cancer (PSN-1), cervical cancer (A431), breast cancer (MDA-MB-231), ovarian cancer (2008), cisplatin-resistant ovarian adenocarcinoma (C13), and small-cell lung cancer (U1285) solid tumor cell lines.

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PMC11013014

The viability of both HL60 and HCT116 was measured for all the synthesised compounds at 1 μM final concentration.

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PMC11687167

It might mediate inflammation and regulate other types of immune cells.

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PMC9429973

They are inherited in an autosomal recessive manner.

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PMC11011837

We also calculated the percentage of lipid classes among each cell line analyzed (see Figure 4).

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PMC4270159

e. Incubate at room temperature for 5 min.

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PMC9429973

The time to event endpoints will be analyzed based on the intent-to-treat population using a stratified log-rank test.

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PMC6114978

In silico studies have suggested that copy number changes (deletions) of genes upstream of the Hippo kinases (e.g. NF2) may result inactivation of TAZ and YAP , however the frequency of these genomic alterations is incompletely understood.

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PMC11700165

Both ITK-SYK- and BTK-SYK-encoding plasmids rendered BAF3 cells IL-3-independent.

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PMC11767725

Therapeutic Studies: Relevant therapeutic studies were defined as those investigating microbiota-targeted interventions (e.g., probiotics, postbiotics, or phage therapy) and/or systemic treatments addressing underlying metabolic dysfunction.

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PMC11380454

of the binding of PD-L1 to PD-1 on both cell types increased cell viability and resistance to chemotherapy, while treatment with SAS significantly sensitized these cells to chemotherapy (Fig. 7A and.

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PMC11407042

Observe the cell adhesion under the inverted microscope.

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PMC11459296

DAPI (62248,Thermo Fisher) was added for nuclear staining, and sections were mounted with Vectashield (H-1000-10, Vector Laboratories).

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PMC9429973

Median age was 49.9 years (range 21–65).

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PMC9429973

Glutaminase (GLS) is the initial enzyme in glutamine metabolism and glutaminolysis contributes to tumor growth.

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PMC10772747

Statistical analysis demonstrates that EBE treatment significantly differs from the control group in terms of the number of cells undergoing apoptosis.

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PMC9428827

Mice were treated i.p.

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PMC11634794

These findings suggest that LAMP1 may primarily function in the late stages of autophagy and might not be involved in its initiation or fusion between autophagosomes and lysosomes.

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PMC10094992

Quantification of malondialdehyde in samples was performed by using the calibration curve obtained by analysis of malondialdehyde tetrabutylammonium standard solutions in the range 10–1000 nM derivatized with DCHD.

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PMC9429973

L. J. Nastoupil, S. O’Brien, H. E. Holmes, L. Dsouza, D. Hart, E. Matsuda, T. Satterfield-Ledbetter, J. Skoble, E. Garner, M. Bryan, S. Kanner, E. Li, C. T. Thomas, J. Essell Lymphoma/Myeloma, UT MD Anderson Cancer Center, Houston; Department of Hematology and Oncology, University of California Irvine, Irvine; Oncology, Texas Oncology/Baylor Sammons Cancer Center, Dallas; Research, Oncology Hematology Care, Cincinnati; UCI Cancer Center, University of California Irvine, Irvine; Clinical Oncology Research Coordination, Baylor Research Institution, Dallas; Technical Operations; T Cell Therapeutics; Program Management/Operations; R&D, Caribou Biosciences, Inc., Berkeley; EffectStats LLC, Cambridge; Clinical Development, Caribou Biosciences, Inc., Berkeley; Blood Cancer, Oncology Hematology Care, Cincinnati, United States of America Background: Autologous CAR-T cell therapies have shown significant benefit in the treatment of patients (pts) with relapsed/refractory B cell NHL (r/r B-NHL).

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PMC11279397

Furthermore, β-sitosterol displayed great antiviral potential against avian and human IAVs in vitro .

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PMC11519077

Our data showed that NOD1 was expressed significantly higher in the IL-1β-induced Caco-2 group compared to the control group.

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PMC11406030

Our results showed that treatment with LMTK3 protein significantly induces integrin αV/β1 levels in a dose-response manner in ovarian cancer cells.

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PMC11593713

It is known that patients with SARS-CoV-2 infection who presented decreased TAC serum levels were more prone to disease exacerbation.

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PMC11742431

The 0 h as a control. (

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PMC11257988

This provides a feasible strategy for targeting RTK for cancer treatment .

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PMC11474209

Since they can probe surface coatings utilizing a variety of optical phenomena while attaining low impedance and high sensitivity, optical sensors have a good deal of opportunity in this area.

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PMC9429973

Methods: Clinical data were obtained from 2551 NDMM patients, followed up for ≥ 36 months or having died or progressed within 36 months post treatment.

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PMC9100622

The cells were treated with 0.5 µM (A673), 2.6 µM (TC71), and 2.4 µM (POE) Atorvastatin for 72 h. The implication of the mevalonate pathway in the cytotoxic effects of statins on Ewing cell lines and PDX-dissociated cells was assessed by rescue experiments performed by the addition of intermediate products of lipid/cholesterol synthesis.

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PMC9429973

The mean levels of selected hemolytic markers (including bilirubin, LDH, reticulocytes), were decreased compared to baseline at the last available on-treatment time point, returning towards baseline 9 weeks after the last sutimlimab dose (Figure 1).

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PMC6835428

PVTC was used as it contains positively charged amino groups, which allow siRNA binding.

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PMC9429973

Pts attaining a complete or partial response received maintenance with the same antibody every 2 months for 2 years or until disease progression (PD).

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PMC11496728

Fig. 5Effect of Apaf1 knockout on apoptosis. (

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PMC9429973

The primary endpoint of the study was progression-free survival (PFS).

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PMC9429973

Most GI AEs were grade (G) 1/2 (including nausea, vomiting, and diarrhea) and there were no Tx-related G3/4 GI AEs.

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PMC4270159

Two studies published around the same time as the work of Wilson and colleagues also support the proposed mechanism of acquired resistance to RTK inhibition by signaling from the tumor microenvironment.

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PMC11413393

Overall, MS023 treatment appears to induce a cytostatic phenotype that precedes cell death.

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PMC9429973

Innate immune system is the first line of defense against microbial pathogens, while at the same time it is the orchestrator of adaptive immunity.

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PMC10213199

The in vivo experiments revealed 74 upregulated genes in the low-concentration group, and CG13078 was a commonly downregulated differential gene, which is involved in ascorbate iron reductase activity.

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PMC5330095

Dr. Lowe is currently an adjunct Professor at the University of Maryland School of Medicine as well as the founder of three biotech companies and the Bio-Tech R&D Institute, Kingston Jamaica, all focusing on drug discovery and development.

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PMC11470381

Wash transfected Jurkat cells twice in 1× PBS at 165× g for 3 min.

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PMC11721295

We quantified percentage positive as all staining above a specified threshold over the total area of the image.

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PMC9429973

21-83yo).

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PMC9429973

Clinical management includes red blood cell (RBC) transfusions and splenectomy, which only partially improves anemia.

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PMC9429973

At a median follow-up of 43 months, ZANU was associated with a higher VGPR+CR rate and demonstrated clinically meaningful advantages in long-term safety and tolerability vs IBR.

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PMC7757104

The optical density at 570 nm was determined using a SpectraMax 190 microplate reader.

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PMC11055323

The underlying principle for these condensates formation is multivalent macromolecular interactions, like DNA/RNA molecules and proteins composed of multiple interaction domains and/or intrinsically disordered regions (IDRs) .

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PMC11224020

i, Box plot with minimum to maximum range of mean speed.

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PMC11590005

Values in bold indicate statistically significant difference.

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PMC11536589

We also identified that the β-catenin/Tcf4 complex regulates the expression of MGST1.

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PMC11621493

The most prominent effect of PLA2G4D overexpression on cellular acylglycerol levels in COS7 cells was observed upon MAG supplementation.

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PMC11790599

This indicates a dysfunctional macropinocytotic process that fails to properly fuse with the lysosomal system for subsequent hydrolysis or undergo recycling to the plasma membrane.

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PMC9429973

TOM-1, RS4;11 and REH presented LIP levels higher than the untreated condition, still no significant differences were noticed between the concentrations.

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PMC11575040

Subsequently, the lysates were collected and centrifuged to remove cell debris, and protein assays were conducted using a Bio-Rad Protein Assay kit through a Bradford dye-binding procedure (Bio-Rad Laboratories, Hercules, CA, USA).

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PMC9429973

Three pts (25.0%) had low-grade CRS (by Lee, 2014; Grade 1, n=2; Grade 2, n=1) and there were no Grade 3–4 CRS events.

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