OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC7305184	The efficiency and impact of repeated PEF treatments is however not known.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "efficiency", "and", "impact", "of", "repeated", "PEF", "treatments", "is", "however", "not", "known", "." ] } ]
PMC11297139	d Immnuocytochemistry image illustrating endogenous ARID1A localization in WT, ARID1A, ARID1A + WT and ARID1A + ΔDD cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Immnuocytochemistry", "image", "illustrating", "endogenous", "ARID1A", "localization", "in", "WT", ",", "ARID1A", ",", "ARID1A", "+", "WT", "and", "ARID1A", "+", "ΔDD", "cells", "." ] } ]
PMC11257988	Activated MYC further promotes cell proliferation and migration in KRAS-driven NSCLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activated", "MYC", "further", "promotes", "cell", "proliferation", "and", "migration", "in", "KRAS-driven", "NSCLC", "." ] } ]
PMC4485786	Each dot represents 1 individual tumor. **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "dot", "represents", "1", "individual", "tumor", ".", "", "" ] } ]
PMC10174970	Cell lines with moderately similar gene expression to primary tumors were reported to have a median correlation coefficient of 0.6 in the Cancer Cell Line Encyclopedia (CCLE) project (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "with", "moderately", "similar", "gene", "expression", "to", "primary", "tumors", "were", "reported", "to", "have", "a", "median", "correlation", "coefficient", "of", "0.6", "in", "the", "Cancer", "Cell", "Line", "Encyclopedia", "(", "CCLE", ")", "project", "(", "15", ")", "." ] } ]
PMC11763126	The mice were then euthanized, and lung tissues were collected for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mice", "were", "then", "euthanized", ",", "and", "lung", "tissues", "were", "collected", "for", "further", "analysis", "." ] } ]
PMC9429973	In immunocompetent Em-TCL1 mice, which develop the CLL-like disease with aging, preliminary analysis at 3, 6 and 9 months of age showed higher malignant cells expansion in PB of Em-TCL1-NFKBIE compared with control Em-TCL1 mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "immunocompetent", "Em-TCL1", "mice", ",", "which", "develop", "the", "CLL-like", "disease", "with", "aging", ",", "preliminary", "analysis", "at", "3", ",", "6", "and", "9", "months", "of", "age", "showed", "higher", "malignant", "cells", "expansion", "in", "PB", "of", "Em-TCL1-NFKBIE", "compared", "with", "control", "Em-TCL1", "mice", "." ] } ]
PMC9341513	We also performed simulations of the MCL cell line Z-138, where CCND1 translocates with Chromosome 14 becoming juxtaposed with the IGH Eµ enhancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "performed", "simulations", "of", "the", "MCL", "cell", "line", "Z-138", ",", "where", "CCND1", "translocates", "with", "Chromosome", "14", "becoming", "juxtaposed", "with", "the", "IGH", "Eµ", "enhancer", "." ] } ]
PMC11761919	After incubation, the highest serum dilution that neutralized the virus and inhibited CPE was recorded as the antibody titer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", ",", "the", "highest", "serum", "dilution", "that", "neutralized", "the", "virus", "and", "inhibited", "CPE", "was", "recorded", "as", "the", "antibody", "titer", "." ] } ]
PMC11743316	Prior studies revealed that ovarian carcinoma is strongly linked to mitochondrial dysfunction [, , ].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "studies", "revealed", "that", "ovarian", "carcinoma", "is", "strongly", "linked", "to", "mitochondrial", "dysfunction", "[", ",", ",", "]", "." ] } ]
PMC11731614	Protein was then transferred to PVDF membranes (Millipore) and blocked (BioRad Everyblot 12010020) for 15 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "was", "then", "transferred", "to", "PVDF", "membranes", "(", "Millipore", ")", "and", "blocked", "(", "BioRad", "Everyblot", "12010020", ")", "for", "15", "min", "." ] } ]
PMC11658074	The yield of AT-EVs from the same volume of AT was 200 times greater than that of ADSC-EVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "yield", "of", "AT-EVs", "from", "the", "same", "volume", "of", "AT", "was", "200", "times", "greater", "than", "that", "of", "ADSC-EVs", "." ] } ]
PMC11422497	Furthermore, the Receiver Operating Characteristic (ROC) curve analysis highlighted the high diagnostic efficiency of circ_SMA4, with an Area Under the Curve (AUC) of 0.9824 (P < 0.01; Figure Supplemental Fig. 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "Receiver", "Operating", "Characteristic", "(", "ROC", ")", "curve", "analysis", "highlighted", "the", "high", "diagnostic", "efficiency", "of", "circ_SMA4", ",", "with", "an", "Area", "Under", "the", "Curve", "(", "AUC", ")", "of", "0.9824", "(", "P", "<", "0.01", ";", "Figure", "Supplemental", "Fig.", "1D", ")", "." ] } ]
PMC11731614	Fraction 2/3 was enriched with CD63-GFP and soluble GFP, supporting that KDEVs from primary cultured keratinocytes from our EV-reporter mouse line are tagged with GFP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fraction", "2/3", "was", "enriched", "with", "CD63-GFP", "and", "soluble", "GFP", ",", "supporting", "that", "KDEVs", "from", "primary", "cultured", "keratinocytes", "from", "our", "EV-reporter", "mouse", "line", "are", "tagged", "with", "GFP", "." ] } ]
PMC11731161	F NCI-H929 cells were transfected with indicated tet-on-shRNA, cells were treated with 10 µM MG132 for 6 h prior to collection, then XPO1 were immunoprecipitated with anti-XPO1 antibody, ubiquitination levels of endogenous XPO1 protein were analyzed by immunoblotting using the ubiquitin antibody.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "NCI-H929", "cells", "were", "transfected", "with", "indicated", "tet-on-shRNA", ",", "cells", "were", "treated", "with", "10", "µM", "MG132", "for", "6", "h", "prior", "to", "collection", ",", "then", "XPO1", "were", "immunoprecipitated", "with", "anti-XPO1", "antibody", ",", "ubiquitination", "levels", "of", "endogenous", "XPO1", "protein", "were", "analyzed", "by", "immunoblotting", "using", "the", "ubiquitin", "antibody", "." ] } ]
PMC11412752	Primers are shown in Table 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primers", "are", "shown", "in", "Table", "4", "." ] } ]
PMC11678841	However, we observed reduced activity of this kinase in our experimental model, possibly due to the different time of infection (3 h in our study vs. 2 h post-infection reported in ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "we", "observed", "reduced", "activity", "of", "this", "kinase", "in", "our", "experimental", "model", ",", "possibly", "due", "to", "the", "different", "time", "of", "infection", "(", "3", "h", "in", "our", "study", "vs.", "2", "h", "post-infection", "reported", "in", ")", "." ] } ]
PMC11271278	The fluorescence signals were captured and detected using a Plan Apo 60x objective (Nikon, NA 1.40) and a high-speed Kinetix sCMOS camera (Photometrics), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescence", "signals", "were", "captured", "and", "detected", "using", "a", "Plan", "Apo", "60x", "objective", "(", "Nikon", ",", "NA", "1.40", ")", "and", "a", "high-speed", "Kinetix", "sCMOS", "camera", "(", "Photometrics", ")", ",", "respectively", "." ] } ]
PMC11789597	Relative mRNA expression was normalized to GAPDH or β‐actin using the 2 method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "mRNA", "expression", "was", "normalized", "to", "GAPDH", "or", "β‐actin", "using", "the", "2", "method", "." ] } ]
PMC8735881	In brief, a total of 1.5 × 10 HEK293T cells were seeded in a P-150 dish in 25 ml of complete DMEM and cultured at 37°C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "a", "total", "of", "1.5", "×", "10", "HEK293", "T", "cells", "were", "seeded", "in", "a", "P-150", "dish", "in", "25", "ml", "of", "complete", "DMEM", "and", "cultured", "at", "37", "°", "C", "overnight", "." ] } ]
PMC10932641	Antisense oligonucleotide (ASO) technology and nanoparticle-mediated RNA interference can be used to knock down overexpressed oncogenic lncRNA in cancer, and have shown promising anti-cancer effects (59).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antisense", "oligonucleotide", "(", "ASO", ")", "technology", "and", "nanoparticle-mediated", "RNA", "interference", "can", "be", "used", "to", "knock", "down", "overexpressed", "oncogenic", "lncRNA", "in", "cancer", ",", "and", "have", "shown", "promising", "anti-cancer", "effects", "(", "59", ")", "." ] } ]
PMC6650823	Glioblastoma is one of the most aggressive and common malignant brain tumors with a median survival of less than two years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glioblastoma", "is", "one", "of", "the", "most", "aggressive", "and", "common", "malignant", "brain", "tumors", "with", "a", "median", "survival", "of", "less", "than", "two", "years", "." ] } ]
PMC11566417	Lastly, we compared the immunomodulatory properties of CM collected from primary and immortalized MDECs at both p10 and p20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly", ",", "we", "compared", "the", "immunomodulatory", "properties", "of", "CM", "collected", "from", "primary", "and", "immortalized", "MDECs", "at", "both", "p10", "and", "p20", "." ] } ]
PMC6461034	Clearly, “kinome” analysis (Fig 2, first column of bar graphs) strongly suggests identification of hyperactive kinases, as was found previously (Rikova et al, 2007; Guo et al, 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clearly", ",", "“", "kinome", "”", "analysis", "(", "Fig", "2", ",", "first", "column", "of", "bar", "graphs", ")", "strongly", "suggests", "identification", "of", "hyperactive", "kinases", ",", "as", "was", "found", "previously", "(", "Rikova", "et", "al", ",", "2007", ";", "Guo", "et", "al", ",", "2008", ")", "." ] } ]
PMC9429973	These results provide a rational for the development of novel combination therapeutic approach for PMF patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "provide", "a", "rational", "for", "the", "development", "of", "novel", "combination", "therapeutic", "approach", "for", "PMF", "patients", "." ] } ]
PMC11742670	Figure 4 presents the process of data collection and preprocessing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4", "presents", "the", "process", "of", "data", "collection", "and", "preprocessing", "." ] } ]
PMC11610461	Gene expression profiles of the GSE150404 dataset were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/) database (Hutter & Zenklusen, 2018; Barrett et al., 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "profiles", "of", "the", "GSE150404", "dataset", "were", "obtained", "from", "Gene", "Expression", "Omnibus", "(", "GEO", ",", "https://www.ncbi.nlm.nih.gov/geo/", ")", "database", "(", "Hutter", "&", "Zenklusen", ",", "2018", ";", "Barrett", "et", "al.", ",", "2011", ")", "." ] } ]
PMC11578343	From top to bottom, time snapshots of a single MCF‐7 cell (indicated by a red arrow) exiting one sinusoidal contraction zone (Lzone = 2 mm, L p = 300 µm, w contraction = 11.25 + 2.75cos(ωt) µm), transiting though an inter‐zone node of width w p = 21 µm, and finally entering a new sinusoidal contraction zone of different frequency (L p = 200 µm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "top", "to", "bottom", ",", "time", "snapshots", "of", "a", "single", "MCF‐7", "cell", "(", "indicated", "by", "a", "red", "arrow", ")", "exiting", "one", "sinusoidal", "contraction", "zone", "(", "Lzone", "=", "2", "mm", ",", "L", "p", "=", "300", "µm", ",", "w", "contraction", "=", "11.25", "+", "2.75cos(ωt", ")", "µm", ")", ",", "transiting", "though", "an", "inter‐zone", "node", "of", "width", "w", "p", "=", "21", "µm", ",", "and", "finally", "entering", "a", "new", "sinusoidal", "contraction", "zone", "of", "different", "frequency", "(", "L", "p", "=", "200", "µm", ")", "." ] } ]
PMC11047729	The most effective concentration of I3C was 400 μM of the substance after 32 h; it has to be noted that 200 μM had no effect on c-Myc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "effective", "concentration", "of", "I3C", "was", "400", "μM", "of", "the", "substance", "after", "32", "h", ";", "it", "has", "to", "be", "noted", "that", "200", "μM", "had", "no", "effect", "on", "c-Myc", "." ] } ]
PMC10890307	The µ was 80% higher in normoxic conditions compared to hypoxic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "µ", "was", "80", "%", "higher", "in", "normoxic", "conditions", "compared", "to", "hypoxic", "conditions", "." ] } ]
PMC8469018	The primary mechanism of action is inhibition of de novo pyrimidine synthesis by targeting dihydroorotate dehydrogenase (DHODH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "mechanism", "of", "action", "is", "inhibition", "of", "de", "novo", "pyrimidine", "synthesis", "by", "targeting", "dihydroorotate", "dehydrogenase", "(", "DHODH", ")", "." ] } ]
PMC2118063	Subsets of tonsillar B cells as defined by expression of IgD and CD38 were purified by flow cytometric sorting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsets", "of", "tonsillar", "B", "cells", "as", "defined", "by", "expression", "of", "IgD", "and", "CD38", "were", "purified", "by", "flow", "cytometric", "sorting", "." ] } ]
PMC6650823	The groups of Christian Ottmann at the Laboratory of Chemical Biology, Eindhoven University of Technology, and Michelle R. Arkin at the Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, together with collaborators have provided a highly interesting study on a site-directed screening technique to successfully select fragments that enhance the affinity between protein partners .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "groups", "of", "Christian", "Ottmann", "at", "the", "Laboratory", "of", "Chemical", "Biology", ",", "Eindhoven", "University", "of", "Technology", ",", "and", "Michelle", "R.", "Arkin", "at", "the", "Department", "of", "Pharmaceutical", "Chemistry", "and", "Small", "Molecule", "Discovery", "Center", ",", "University", "of", "California", ",", "together", "with", "collaborators", "have", "provided", "a", "highly", "interesting", "study", "on", "a", "site-directed", "screening", "technique", "to", "successfully", "select", "fragments", "that", "enhance", "the", "affinity", "between", "protein", "partners", "." ] } ]
PMC9429973	Itolizumab is a humanized IgG1 monoclonal antibody that binds CD6 and blocks interaction with activated leukocyte cell adhesion molecule (ALCAM) to inhibit T effector cell activity and trafficking to target organs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Itolizumab", "is", "a", "humanized", "IgG1", "monoclonal", "antibody", "that", "binds", "CD6", "and", "blocks", "interaction", "with", "activated", "leukocyte", "cell", "adhesion", "molecule", "(", "ALCAM", ")", "to", "inhibit", "T", "effector", "cell", "activity", "and", "trafficking", "to", "target", "organs", "." ] } ]
PMC11790971	The statical differences in cell feature distributions between different cell lines were assessed using the Mann–Whitney U tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statical", "differences", "in", "cell", "feature", "distributions", "between", "different", "cell", "lines", "were", "assessed", "using", "the", "Mann", "–", "Whitney", "U", "tests", "." ] } ]
PMC10976516	For instance, carrier cells can gain increased tropism for tumors through transgenic expression of appropriate chemo- or cytokines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "instance", ",", "carrier", "cells", "can", "gain", "increased", "tropism", "for", "tumors", "through", "transgenic", "expression", "of", "appropriate", "chemo-", "or", "cytokines", "." ] } ]
PMC9429973	Median age of AML-LTS was 61y (range 28y-93y), and 56% were female.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "age", "of", "AML-LTS", "was", "61y", "(", "range", "28y-93y", ")", ",", "and", "56", "%", "were", "female", "." ] } ]
PMC11767793	Several potential modes of NP interference with the MTS assay were proposed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "potential", "modes", "of", "NP", "interference", "with", "the", "MTS", "assay", "were", "proposed", "." ] } ]
PMC7171147	Taken together, these results suggest that AMPK acts as a downstream effector of COL11A1-DDR2-Src-Akt signaling to upregulate FAO in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "these", "results", "suggest", "that", "AMPK", "acts", "as", "a", "downstream", "effector", "of", "COL11A1-DDR2-Src-Akt", "signaling", "to", "upregulate", "FAO", "in", "ovarian", "cancer", "cells", "." ] } ]
PMC9370419	The primer sequences were as follows: forward 5′-ATATCGAGCTCCATGGCTGCTCGGGTGT-3′, reverse 5′-CCCAAGCTTGGGTTAGGCAGAGGTGAAAAA-3′. The pSBTetHX plasmid was designed by replacing the luciferase fragment of pSBtet-GH with the HiBiT-HBx fragment cloned from the HiBit-X6 plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primer", "sequences", "were", "as", "follows", ":", "forward", "5′-ATATCGAGCTCCATGGCTGCTCGGGTGT-3′", ",", "reverse", "5′-CCCAAGCTTGGGTTAGGCAGAGGTGAAAAA-3′.", "The", "pSBTetHX", "plasmid", "was", "designed", "by", "replacing", "the", "luciferase", "fragment", "of", "pSBtet-GH", "with", "the", "HiBiT-HBx", "fragment", "cloned", "from", "the", "HiBit-X6", "plasmid", "." ] } ]
PMC11411131	GPx1, which was fused with a FLAG tag and an HA tag, was exogenously expressed in Cos-7 cells and analyzed via sodium dodecyl sulfate poly-acrylamide gel electrophoresis (SDS-PAGE) followed by western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPx1", ",", "which", "was", "fused", "with", "a", "FLAG", "tag", "and", "an", "HA", "tag", ",", "was", "exogenously", "expressed", "in", "Cos-7", "cells", "and", "analyzed", "via", "sodium", "dodecyl", "sulfate", "poly-acrylamide", "gel", "electrophoresis", "(", "SDS-PAGE", ")", "followed", "by", "western", "blotting", "." ] } ]
PMC11122631	12-O-deacetylclavulone I (2) was isolated as a colorless oil.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "12-O-deacetylclavulone", "I", "(", "2", ")", "was", "isolated", "as", "a", "colorless", "oil", "." ] } ]
PMC11782780	To probe into the mechanism of EBF3 in regulating the stem-like phenotype of BC cells, we performed GSEA of EBF3 and found great enrichment in the glycolysis/gluconeogenesis metabolic pathway (Fig. 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "probe", "into", "the", "mechanism", "of", "EBF3", "in", "regulating", "the", "stem-like", "phenotype", "of", "BC", "cells", ",", "we", "performed", "GSEA", "of", "EBF3", "and", "found", "great", "enrichment", "in", "the", "glycolysis/gluconeogenesis", "metabolic", "pathway", "(", "Fig.", "3A", ")", "." ] } ]
PMC11377827	Surprisingly, the USP43 mutant also partially restored HIF reporter activity and CA9 levels (Fig. 4F–I), suggesting that while USP43 enzymatic activity may be involved, deubiquitination itself was not essential for the effect of USP43 on HIF-mediated transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surprisingly", ",", "the", "USP43", "mutant", "also", "partially", "restored", "HIF", "reporter", "activity", "and", "CA9", "levels", "(", "Fig.", "4F", "–", "I", ")", ",", "suggesting", "that", "while", "USP43", "enzymatic", "activity", "may", "be", "involved", ",", "deubiquitination", "itself", "was", "not", "essential", "for", "the", "effect", "of", "USP43", "on", "HIF-mediated", "transcription", "." ] } ]
PMC9688728	F-ratio is calculated as the ratio of class-to-class variation to within-class variation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F-ratio", "is", "calculated", "as", "the", "ratio", "of", "class-to-class", "variation", "to", "within-class", "variation", "." ] } ]
PMC9080589	Therefore, blocking Wnt/β-catenin signaling pathway could suppress metastatic potential and tumorigenesis in PTC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "blocking", "Wnt/β-catenin", "signaling", "pathway", "could", "suppress", "metastatic", "potential", "and", "tumorigenesis", "in", "PTC", "." ] } ]
PMC9429973	Although some RNA molecules, especially non-coding RNAs, were reported to modulate transcription in leukemia cells, the regulatory role of genome-wide RNAs on transcription through chromatin association remains largely unexplored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "some", "RNA", "molecules", ",", "especially", "non-coding", "RNAs", ",", "were", "reported", "to", "modulate", "transcription", "in", "leukemia", "cells", ",", "the", "regulatory", "role", "of", "genome-wide", "RNAs", "on", "transcription", "through", "chromatin", "association", "remains", "largely", "unexplored", "." ] } ]
PMC9856122	Similarly, HIV is also a major health concern worldwide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "HIV", "is", "also", "a", "major", "health", "concern", "worldwide", "." ] } ]
PMC7342409	Imatinib had a weak inhibitory effect on the growth of GIST882-ir cells, while CQ had no effect on the growth of GIST882-ir cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Imatinib", "had", "a", "weak", "inhibitory", "effect", "on", "the", "growth", "of", "GIST882-ir", "cells", ",", "while", "CQ", "had", "no", "effect", "on", "the", "growth", "of", "GIST882-ir", "cells", "." ] } ]
PMC11795610	During the differentiation of keratinocytes induced by 1.8 mM Ca, myricetin could inhibit keratinocyte growth, and promote cell cycle arrest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "differentiation", "of", "keratinocytes", "induced", "by", "1.8", "mM", "Ca", ",", "myricetin", "could", "inhibit", "keratinocyte", "growth", ",", "and", "promote", "cell", "cycle", "arrest", "." ] } ]
PMC10204952	After incubation, the cells were first fixed in 4% paraformaldehyde for 20 min and rinsed with 1X PBS twice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", ",", "the", "cells", "were", "first", "fixed", "in", "4", "%", "paraformaldehyde", "for", "20", "min", "and", "rinsed", "with", "1X", "PBS", "twice", "." ] } ]
PMC11768927	To counteract resistance observed in specific tumor subpopulations or metastatic lesions, numerous studies have integrated inhibitors of cellular resistance with VSV treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "counteract", "resistance", "observed", "in", "specific", "tumor", "subpopulations", "or", "metastatic", "lesions", ",", "numerous", "studies", "have", "integrated", "inhibitors", "of", "cellular", "resistance", "with", "VSV", "treatment", "." ] } ]
PMC11013014	Drug-likeness parameters were calculated in silico using the SwissADME web server .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug-likeness", "parameters", "were", "calculated", "in", "silico", "using", "the", "SwissADME", "web", "server", "." ] } ]
PMC11753435	Top 1 accuracy is the likelihood that for a given protein, the model has chosen the correct binding peptide, and top 10% accuracy is the likelihood that this peptide is in the top 10% of peptides when ranked for the CLIP score to this protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top", "1", "accuracy", "is", "the", "likelihood", "that", "for", "a", "given", "protein", ",", "the", "model", "has", "chosen", "the", "correct", "binding", "peptide", ",", "and", "top", "10", "%", "accuracy", "is", "the", "likelihood", "that", "this", "peptide", "is", "in", "the", "top", "10", "%", "of", "peptides", "when", "ranked", "for", "the", "CLIP", "score", "to", "this", "protein", "." ] } ]
PMC11687167	The expression of PCSK9 dependented on the kinase pathways of JAK1/2 and MEK1 (mitogen-activated protein kinase kinase 1)/ERK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "PCSK9", "dependented", "on", "the", "kinase", "pathways", "of", "JAK1/2", "and", "MEK1", "(", "mitogen-activated", "protein", "kinase", "kinase", "1)/ERK", "." ] } ]
PMC11590870	The samples from selected three-year-old plants were harvested and taken into the laboratory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "from", "selected", "three-year-old", "plants", "were", "harvested", "and", "taken", "into", "the", "laboratory", "." ] } ]
PMC8382973	The toxicity of HEC against TZM-bl cells was measured using a CCK-8 assay kit.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "toxicity", "of", "HEC", "against", "TZM-bl", "cells", "was", "measured", "using", "a", "CCK-8", "assay", "kit", "." ] } ]
PMC11412721	With this strategy, we obtained puromycin-resistant clones from Raji cells, two of which were verified to be ACKR4 KO clones by DNA sequencing (Figure 4—figure supplement 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "strategy", ",", "we", "obtained", "puromycin-resistant", "clones", "from", "Raji", "cells", ",", "two", "of", "which", "were", "verified", "to", "be", "ACKR4", "KO", "clones", "by", "DNA", "sequencing", "(", "Figure", "4—figure", "supplement", "3", ")", "." ] } ]
PMC9429973	M. Rodríguez, J. Cornago, J. Serrano, R. Alonso Alonso, D. Morillo, M. A. Perez Saenz, J. M. Alonso Dominguez, M. A. Piris, J. Sánchez García, P. Llamas Sillero, J. Serrano Lopez Pathology, IIS-Fundación Jiménez Díaz, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC); Hematology, Fundación Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, UAM, Madrid; Hematology, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Cordoba; Experimental Hematology Lab, IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain Background: Activated B-cell (ABC) lymphomas emerged as a distinct molecular subtype within Diffuse Large B-Cell Lymphoma (DLBCL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "M.", "Rodríguez", ",", "J.", "Cornago", ",", "J.", "Serrano", ",", "R.", "Alonso", "Alonso", ",", "D.", "Morillo", ",", "M.", "A.", "Perez", "Saenz", ",", "J.", "M.", "Alonso", "Dominguez", ",", "M.", "A.", "Piris", ",", "J.", "Sánchez", "García", ",", "P.", "Llamas", "Sillero", ",", "J.", "Serrano", "Lopez", "Pathology", ",", "IIS-Fundación", "Jiménez", "Díaz", ",", "Centro", "de", "Investigación", "Biomédica", "en", "Red", "de", "Cáncer", "(", "CIBERONC", ")", ";", "Hematology", ",", "Fundación", "Jimenez", "Diaz", "University", "Hospital", ",", "Health", "Research", "Institute", "IIS-FJD", ",", "UAM", ",", "Madrid", ";", "Hematology", ",", "Reina", "Sofía", "University", "Hospital/Maimonides", "Biomedical", "Research", "Institute", "of", "Córdoba", "(IMIBIC)/University", "of", "Córdoba", ",", "Cordoba", ";", "Experimental", "Hematology", "Lab", ",", "IIS-Fundación", "Jiménez", "Díaz", ",", "UAM", ",", "Madrid", ",", "Spain", "Background", ":", "Activated", "B-cell", "(", "ABC", ")", "lymphomas", "emerged", "as", "a", "distinct", "molecular", "subtype", "within", "Diffuse", "Large", "B-Cell", "Lymphoma", "(", "DLBCL", ")", "." ] } ]
PMC9429973	The blood film was revised for assesment of platelet size and morphology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "blood", "film", "was", "revised", "for", "assesment", "of", "platelet", "size", "and", "morphology", "." ] } ]
PMC10376064	We extracted total protein from the brain and first quantified aggregated Aβ42 in the guanidine-soluble fractions (Figure 5A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "extracted", "total", "protein", "from", "the", "brain", "and", "first", "quantified", "aggregated", "Aβ42", "in", "the", "guanidine-soluble", "fractions", "(", "Figure", "5A", ",", "B", ")", "." ] } ]
PMC9429973	104 AEs were recorded, of which G1 45%, G2 32%, G3 22% and G4 1%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "104", "AEs", "were", "recorded", ",", "of", "which", "G1", "45", "%", ",", "G2", "32", "%", ",", "G3", "22", "%", "and", "G4", "1", "%", "." ] } ]
PMC8735881	Similar to their inhibitory activities on replication-competent HIV-1 isolates and pseudoviruses, GPI-scFvs also exhibited different degrees of breadth and potency in blocking cell–cell fusion mediated by a panel of primary HIV-1 Envs with diverse subtypes and phenotypes (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "their", "inhibitory", "activities", "on", "replication-competent", "HIV-1", "isolates", "and", "pseudoviruses", ",", "GPI-scFvs", "also", "exhibited", "different", "degrees", "of", "breadth", "and", "potency", "in", "blocking", "cell", "–", "cell", "fusion", "mediated", "by", "a", "panel", "of", "primary", "HIV-1", "Envs", "with", "diverse", "subtypes", "and", "phenotypes", "(", "Table", "1", ")", "." ] } ]
PMC10870498	Nevertheless, the specific regulatory mechanism of succinylation in ATC remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "the", "specific", "regulatory", "mechanism", "of", "succinylation", "in", "ATC", "remains", "unclear", "." ] } ]
PMC11593084	Similarly, LpMab-2-based CAR-T cells killed patient-derived glioma stem cells and suppressed the growth of a glioma xenograft in immunodeficient mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "LpMab-2-based", "CAR-T", "cells", "killed", "patient-derived", "glioma", "stem", "cells", "and", "suppressed", "the", "growth", "of", "a", "glioma", "xenograft", "in", "immunodeficient", "mice", "." ] } ]
PMC10743717	that the reported kinetic constants (see the right column of Table 2 reproduced from Ref. )	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "that", "the", "reported", "kinetic", "constants", "(", "see", "the", "right", "column", "of", "Table", "2", "reproduced", "from", "Ref", ".", ")" ] } ]
PMC9429973	The safety, tolerability, recommended dosing, immunogenicity, and antitumor activity of A+AVD have not previously been evaluated as a first-line therapy in treatment-naïve pediatric patients with cHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "safety", ",", "tolerability", ",", "recommended", "dosing", ",", "immunogenicity", ",", "and", "antitumor", "activity", "of", "A+AVD", "have", "not", "previously", "been", "evaluated", "as", "a", "first-line", "therapy", "in", "treatment-naïve", "pediatric", "patients", "with", "cHL", "." ] } ]
PMC11228511	The detection of NM ruptures was performed as previously described (21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detection", "of", "NM", "ruptures", "was", "performed", "as", "previously", "described", "(", "21", ")", "." ] } ]
PMC11506670	Expression of the wild-type and mutant NRAS proteins was confirmed via Western blot analysis (Supplementary Figure S1), following the protocol described below.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "the", "wild-type", "and", "mutant", "NRAS", "proteins", "was", "confirmed", "via", "Western", "blot", "analysis", "(", "Supplementary", "Figure", "S1", ")", ",", "following", "the", "protocol", "described", "below", "." ] } ]
PMC11680562	Subsequently, the aqueous drug solution and CuO NPs suspension were introduced into the polymer solution, followed by the addition of a CaCl2 solution (Fig. 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "aqueous", "drug", "solution", "and", "CuO", "NPs", "suspension", "were", "introduced", "into", "the", "polymer", "solution", ",", "followed", "by", "the", "addition", "of", "a", "CaCl2", "solution", "(", "Fig.", "4", ")", "." ] } ]
PMC9429973	Demographic, standard laboratory and AML-related parameters (blood/bone marrow blast percentage, cytologic, flow cytometry and genetic markers enabling ELN risk stratification were collected from patients’ health records.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Demographic", ",", "standard", "laboratory", "and", "AML-related", "parameters", "(", "blood/bone", "marrow", "blast", "percentage", ",", "cytologic", ",", "flow", "cytometry", "and", "genetic", "markers", "enabling", "ELN", "risk", "stratification", "were", "collected", "from", "patients", "’", "health", "records", "." ] } ]
PMC9429973	The primers recommended by Europe Against Cancer Association (EAC) and widely used (including as part of commercial diagnostic kits) flank 687bp ABL1 gene DNA fragment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primers", "recommended", "by", "Europe", "Against", "Cancer", "Association", "(", "EAC", ")", "and", "widely", "used", "(", "including", "as", "part", "of", "commercial", "diagnostic", "kits", ")", "flank", "687bp", "ABL1", "gene", "DNA", "fragment", "." ] } ]
PMC7642379	For finding differentially expressed pathways of genes between adherent and suspension cell lines, we used the Wilcoxon statistical test and filtered gene sets with adjusted p-value lower than 0.05 as significantly changed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "finding", "differentially", "expressed", "pathways", "of", "genes", "between", "adherent", "and", "suspension", "cell", "lines", ",", "we", "used", "the", "Wilcoxon", "statistical", "test", "and", "filtered", "gene", "sets", "with", "adjusted", "p-value", "lower", "than", "0.05", "as", "significantly", "changed", "." ] } ]
PMC11792888	Scorpion venom was eluted at 1 mL/min flow rate using a linear gradient of 0-45% of solvent B for 45 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scorpion", "venom", "was", "eluted", "at", "1", "mL/min", "flow", "rate", "using", "a", "linear", "gradient", "of", "0", "-", "45", "%", "of", "solvent", "B", "for", "45", "min", "." ] } ]
PMC8922418	We noticed that the natural CXCR4 P191A mutant could inhibit X4 tropic HIV-1 infection without impairing HSC differentiation (Liu et al., 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "noticed", "that", "the", "natural", "CXCR4", "P191A", "mutant", "could", "inhibit", "X4", "tropic", "HIV-1", "infection", "without", "impairing", "HSC", "differentiation", "(", "Liu", "et", "al.", ",", "2014", ")", "." ] } ]
PMC8584319	Next, we investigated the role of MAPKs in AZD8055-mediated inhibition of protein synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "investigated", "the", "role", "of", "MAPKs", "in", "AZD8055-mediated", "inhibition", "of", "protein", "synthesis", "." ] } ]
PMC9509578	Bahadur et al. synthesized poly (2-)pyridine-2-yldisulfanyl)ethyl acrylate) (PDS) nanoparticles loaded with doxorubicin and decorated with a cRGD peptide and observed their stability and drug release in both acidic pH and redox potential conditions in colon cancer HCT-116 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Bahadur", "et", "al.", "synthesized", "poly", "(2-)pyridine-2-yldisulfanyl)ethyl", "acrylate", ")", "(", "PDS", ")", "nanoparticles", "loaded", "with", "doxorubicin", "and", "decorated", "with", "a", "cRGD", "peptide", "and", "observed", "their", "stability", "and", "drug", "release", "in", "both", "acidic", "pH", "and", "redox", "potential", "conditions", "in", "colon", "cancer", "HCT-116", "cells", "." ] } ]
PMC9429973	Aims: To report results from the 9-week follow-up visit after the last sutimlimab dose in the CARDINAL study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "report", "results", "from", "the", "9-week", "follow-up", "visit", "after", "the", "last", "sutimlimab", "dose", "in", "the", "CARDINAL", "study", "." ] } ]
PMC5173112	As expected, decreased binding of USP21 to the promoter regions of IL-8 was associated with increased uH2A level and decrease of H3K4me3 levels (Figure 7B and 7C), confirming the function of USP21 in regulating the transcriptional activities of IL-8. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "decreased", "binding", "of", "USP21", "to", "the", "promoter", "regions", "of", "IL-8", "was", "associated", "with", "increased", "uH2A", "level", "and", "decrease", "of", "H3K4me3", "levels", "(", "Figure", "7B", "and", "7C", ")", ",", "confirming", "the", "function", "of", "USP21", "in", "regulating", "the", "transcriptional", "activities", "of", "IL-8", ".", "(" ] } ]
PMC11699465	All the cells were identified by STR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "cells", "were", "identified", "by", "STR", "." ] } ]
PMC9031474	Cinnamodial (7) was less cytotoxic than capsicodendrin (8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cinnamodial", "(", "7", ")", "was", "less", "cytotoxic", "than", "capsicodendrin", "(", "8)", "." ] } ]
PMC11767817	Protein expression was analyzed after 8 h of incubation, and results are presented in Figure 2 and Figure S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "expression", "was", "analyzed", "after", "8", "h", "of", "incubation", ",", "and", "results", "are", "presented", "in", "Figure", "2", "and", "Figure", "S3", "." ] } ]
PMC11321678	A CCAN linked OTX2, whose amplifications are enriched in Group 3 and is identified as super‐enhancer‐associated genes in MBs, exhibits the strongest specificity in Group 3 clusters as well as HLX (Figure 2D; Figure S5A,B, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "CCAN", "linked", "OTX2", ",", "whose", "amplifications", "are", "enriched", "in", "Group", "3", "and", "is", "identified", "as", "super‐enhancer‐associated", "genes", "in", "MBs", ",", "exhibits", "the", "strongest", "specificity", "in", "Group", "3", "clusters", "as", "well", "as", "HLX", "(", "Figure", "2D", ";", "Figure", "S5A", ",", "B", ",", "Supporting", "Information", ")", "." ] } ]
PMC11632064	10.2.3 (GraphPad) or the Microsoft Excel software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "10.2.3", "(", "GraphPad", ")", "or", "the", "Microsoft", "Excel", "software", "." ] } ]
PMC11697189	Except for tumor cells, the other two main components in the tumor microenvironment are immune cells and stromal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Except", "for", "tumor", "cells", ",", "the", "other", "two", "main", "components", "in", "the", "tumor", "microenvironment", "are", "immune", "cells", "and", "stromal", "cells", "." ] } ]
PMC11549612	The impact of BOLA1, BOLA2, and BOLA3 expression on molecular and immune subtypes of KIRC was explored using the TISIDB website.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "impact", "of", "BOLA1", ",", "BOLA2", ",", "and", "BOLA3", "expression", "on", "molecular", "and", "immune", "subtypes", "of", "KIRC", "was", "explored", "using", "the", "TISIDB", "website", "." ] } ]
PMC11519567	In all, 1× Hoechst33342 reagent was used to counterstain the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", ",", "1", "×", "Hoechst33342", "reagent", "was", "used", "to", "counterstain", "the", "nucleus", "." ] } ]
PMC11222184	The performance of the analysis was assessed by p value and q value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "performance", "of", "the", "analysis", "was", "assessed", "by", "p", "value", "and", "q", "value", "." ] } ]
PMC9429973	Pts could receive a second course of CTX130 if response was not achieved but had experienced clinical benefit or disease progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "could", "receive", "a", "second", "course", "of", "CTX130", "if", "response", "was", "not", "achieved", "but", "had", "experienced", "clinical", "benefit", "or", "disease", "progression", "." ] } ]
PMC7305184	Graphical description of the experiment is presented in Fig. 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphical", "description", "of", "the", "experiment", "is", "presented", "in", "Fig.", "5", "." ] } ]
PMC11659734	An in vitro chromosomal aberration assay was performed to evaluate the potential of BPE to induce structural chromosomal damage in human lymphocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "in", "vitro", "chromosomal", "aberration", "assay", "was", "performed", "to", "evaluate", "the", "potential", "of", "BPE", "to", "induce", "structural", "chromosomal", "damage", "in", "human", "lymphocytes", "." ] } ]
PMC9429973	Of 70 who were infected, 65 reported their PC change with A PC drop in 21 (32%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "70", "who", "were", "infected", ",", "65", "reported", "their", "PC", "change", "with", "A", "PC", "drop", "in", "21", "(", "32", "%", ")", "." ] } ]
PMC10728200	Total RNA was extracted using Trizol (Yeasen Biotechnology Shanghai, China) and reverse-transcribed into cDNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "RNA", "was", "extracted", "using", "Trizol", "(", "Yeasen", "Biotechnology", "Shanghai", ",", "China", ")", "and", "reverse-transcribed", "into", "cDNA", "." ] } ]
PMC11011837	Metabolomics and lipidomics are emerging fields of biochemistry that study metabolic pathways and metabolic processes in a biological system .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolomics", "and", "lipidomics", "are", "emerging", "fields", "of", "biochemistry", "that", "study", "metabolic", "pathways", "and", "metabolic", "processes", "in", "a", "biological", "system", "." ] } ]
PMC11371747	Representative figure from three separate experiments (SEM was within the size of the marker). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "figure", "from", "three", "separate", "experiments", "(", "SEM", "was", "within", "the", "size", "of", "the", "marker", ")", ".", "(" ] } ]
PMC11139449	It predicts binding sites across the entire genome by comparing the gRNA sequence with the target genome, helping detect regions where genetic alterations may occur ( 26 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "predicts", "binding", "sites", "across", "the", "entire", "genome", "by", "comparing", "the", "gRNA", "sequence", "with", "the", "target", "genome", ",", "helping", "detect", "regions", "where", "genetic", "alterations", "may", "occur", "(", "26", ")", "." ] } ]
PMC2193049	To address this question in greater detail, we isolated human proteasome and performed in vitro digestion studies using synthetic peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "this", "question", "in", "greater", "detail", ",", "we", "isolated", "human", "proteasome", "and", "performed", "in", "vitro", "digestion", "studies", "using", "synthetic", "peptides", "." ] } ]
PMC11424574	Low: low expression of MTA2; High: high expression of MTA2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Low", ":", "low", "expression", "of", "MTA2", ";", "High", ":", "high", "expression", "of", "MTA2", "." ] } ]
PMC11697189	ROC curve analysis showed the prognostic accuracy of risk signature and other clinical features. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROC", "curve", "analysis", "showed", "the", "prognostic", "accuracy", "of", "risk", "signature", "and", "other", "clinical", "features", ".", "(" ] } ]
PMC8270637	The present findings revealed that TGF-β1 attenuated the killing effect of T cells on SMMC-7721 and Bel-7404 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "present", "findings", "revealed", "that", "TGF-β1", "attenuated", "the", "killing", "effect", "of", "T", "cells", "on", "SMMC-7721", "and", "Bel-7404", "cells", "." ] } ]

PMC7305184

The efficiency and impact of repeated PEF treatments is however not known.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "efficiency", "and", "impact", "of", "repeated", "PEF", "treatments", "is", "however", "not", "known", "." ] } ]

PMC11297139

d Immnuocytochemistry image illustrating endogenous ARID1A localization in WT, ARID1A, ARID1A + WT and ARID1A + ΔDD cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Immnuocytochemistry", "image", "illustrating", "endogenous", "ARID1A", "localization", "in", "WT", ",", "ARID1A", ",", "ARID1A", "+", "WT", "and", "ARID1A", "+", "ΔDD", "cells", "." ] } ]

PMC11257988

Activated MYC further promotes cell proliferation and migration in KRAS-driven NSCLC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activated", "MYC", "further", "promotes", "cell", "proliferation", "and", "migration", "in", "KRAS-driven", "NSCLC", "." ] } ]

PMC4485786

Each dot represents 1 individual tumor. **

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "dot", "represents", "1", "individual", "tumor", ".", "*", "*" ] } ]

PMC10174970

Cell lines with moderately similar gene expression to primary tumors were reported to have a median correlation coefficient of 0.6 in the Cancer Cell Line Encyclopedia (CCLE) project (15).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "with", "moderately", "similar", "gene", "expression", "to", "primary", "tumors", "were", "reported", "to", "have", "a", "median", "correlation", "coefficient", "of", "0.6", "in", "the", "Cancer", "Cell", "Line", "Encyclopedia", "(", "CCLE", ")", "project", "(", "15", ")", "." ] } ]

PMC11763126

The mice were then euthanized, and lung tissues were collected for further analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mice", "were", "then", "euthanized", ",", "and", "lung", "tissues", "were", "collected", "for", "further", "analysis", "." ] } ]

PMC9429973

In immunocompetent Em-TCL1 mice, which develop the CLL-like disease with aging, preliminary analysis at 3, 6 and 9 months of age showed higher malignant cells expansion in PB of Em-TCL1-NFKBIE compared with control Em-TCL1 mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "immunocompetent", "Em-TCL1", "mice", ",", "which", "develop", "the", "CLL-like", "disease", "with", "aging", ",", "preliminary", "analysis", "at", "3", ",", "6", "and", "9", "months", "of", "age", "showed", "higher", "malignant", "cells", "expansion", "in", "PB", "of", "Em-TCL1-NFKBIE", "compared", "with", "control", "Em-TCL1", "mice", "." ] } ]

PMC9341513

We also performed simulations of the MCL cell line Z-138, where CCND1 translocates with Chromosome 14 becoming juxtaposed with the IGH Eµ enhancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "performed", "simulations", "of", "the", "MCL", "cell", "line", "Z-138", ",", "where", "CCND1", "translocates", "with", "Chromosome", "14", "becoming", "juxtaposed", "with", "the", "IGH", "Eµ", "enhancer", "." ] } ]

PMC11761919

After incubation, the highest serum dilution that neutralized the virus and inhibited CPE was recorded as the antibody titer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", ",", "the", "highest", "serum", "dilution", "that", "neutralized", "the", "virus", "and", "inhibited", "CPE", "was", "recorded", "as", "the", "antibody", "titer", "." ] } ]

PMC11743316

Prior studies revealed that ovarian carcinoma is strongly linked to mitochondrial dysfunction [, , ].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "studies", "revealed", "that", "ovarian", "carcinoma", "is", "strongly", "linked", "to", "mitochondrial", "dysfunction", "[", ",", ",", "]", "." ] } ]

PMC11731614

Protein was then transferred to PVDF membranes (Millipore) and blocked (BioRad Everyblot 12010020) for 15 min.

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PMC11658074

The yield of AT-EVs from the same volume of AT was 200 times greater than that of ADSC-EVs.

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PMC11422497

Furthermore, the Receiver Operating Characteristic (ROC) curve analysis highlighted the high diagnostic efficiency of circ_SMA4, with an Area Under the Curve (AUC) of 0.9824 (P < 0.01; Figure Supplemental Fig. 1D).

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PMC11731614

Fraction 2/3 was enriched with CD63-GFP and soluble GFP, supporting that KDEVs from primary cultured keratinocytes from our EV-reporter mouse line are tagged with GFP.

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PMC11731161

F NCI-H929 cells were transfected with indicated tet-on-shRNA, cells were treated with 10 µM MG132 for 6 h prior to collection, then XPO1 were immunoprecipitated with anti-XPO1 antibody, ubiquitination levels of endogenous XPO1 protein were analyzed by immunoblotting using the ubiquitin antibody.

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PMC11412752

Primers are shown in Table 4.

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PMC11678841

However, we observed reduced activity of this kinase in our experimental model, possibly due to the different time of infection (3 h in our study vs. 2 h post-infection reported in ).

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PMC11271278

The fluorescence signals were captured and detected using a Plan Apo 60x objective (Nikon, NA 1.40) and a high-speed Kinetix sCMOS camera (Photometrics), respectively.

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PMC11789597

Relative mRNA expression was normalized to GAPDH or β‐actin using the 2 method.

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PMC8735881

In brief, a total of 1.5 × 10 HEK293T cells were seeded in a P-150 dish in 25 ml of complete DMEM and cultured at 37°C overnight.

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PMC10932641

Antisense oligonucleotide (ASO) technology and nanoparticle-mediated RNA interference can be used to knock down overexpressed oncogenic lncRNA in cancer, and have shown promising anti-cancer effects (59).

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PMC6650823

Glioblastoma is one of the most aggressive and common malignant brain tumors with a median survival of less than two years.

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PMC11566417

Lastly, we compared the immunomodulatory properties of CM collected from primary and immortalized MDECs at both p10 and p20.

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PMC6461034

Clearly, “kinome” analysis (Fig 2, first column of bar graphs) strongly suggests identification of hyperactive kinases, as was found previously (Rikova et al, 2007; Guo et al, 2008).

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PMC9429973

These results provide a rational for the development of novel combination therapeutic approach for PMF patients.

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PMC11742670

Figure 4 presents the process of data collection and preprocessing.

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PMC11610461

Gene expression profiles of the GSE150404 dataset were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/) database (Hutter & Zenklusen, 2018; Barrett et al., 2011).

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PMC11578343

From top to bottom, time snapshots of a single MCF‐7 cell (indicated by a red arrow) exiting one sinusoidal contraction zone (Lzone = 2 mm, L p = 300 µm, w contraction = 11.25 + 2.75cos(ωt) µm), transiting though an inter‐zone node of width w p = 21 µm, and finally entering a new sinusoidal contraction zone of different frequency (L p = 200 µm).

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PMC11047729

The most effective concentration of I3C was 400 μM of the substance after 32 h; it has to be noted that 200 μM had no effect on c-Myc.

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PMC10890307

The µ was 80% higher in normoxic conditions compared to hypoxic conditions.

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PMC8469018

The primary mechanism of action is inhibition of de novo pyrimidine synthesis by targeting dihydroorotate dehydrogenase (DHODH).

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PMC2118063

Subsets of tonsillar B cells as defined by expression of IgD and CD38 were purified by flow cytometric sorting.

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PMC6650823

The groups of Christian Ottmann at the Laboratory of Chemical Biology, Eindhoven University of Technology, and Michelle R. Arkin at the Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, together with collaborators have provided a highly interesting study on a site-directed screening technique to successfully select fragments that enhance the affinity between protein partners .

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PMC9429973

Itolizumab is a humanized IgG1 monoclonal antibody that binds CD6 and blocks interaction with activated leukocyte cell adhesion molecule (ALCAM) to inhibit T effector cell activity and trafficking to target organs.

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PMC11790971

The statical differences in cell feature distributions between different cell lines were assessed using the Mann–Whitney U tests.

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PMC10976516

For instance, carrier cells can gain increased tropism for tumors through transgenic expression of appropriate chemo- or cytokines.

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PMC9429973

Median age of AML-LTS was 61y (range 28y-93y), and 56% were female.

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PMC11767793

Several potential modes of NP interference with the MTS assay were proposed .

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PMC7171147

Taken together, these results suggest that AMPK acts as a downstream effector of COL11A1-DDR2-Src-Akt signaling to upregulate FAO in ovarian cancer cells.

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PMC9370419

The primer sequences were as follows: forward 5′-ATATCGAGCTCCATGGCTGCTCGGGTGT-3′, reverse 5′-CCCAAGCTTGGGTTAGGCAGAGGTGAAAAA-3′. The pSBTetHX plasmid was designed by replacing the luciferase fragment of pSBtet-GH with the HiBiT-HBx fragment cloned from the HiBit-X6 plasmid.

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PMC11411131

GPx1, which was fused with a FLAG tag and an HA tag, was exogenously expressed in Cos-7 cells and analyzed via sodium dodecyl sulfate poly-acrylamide gel electrophoresis (SDS-PAGE) followed by western blotting.

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PMC11122631

12-O-deacetylclavulone I (2) was isolated as a colorless oil.

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PMC11782780

To probe into the mechanism of EBF3 in regulating the stem-like phenotype of BC cells, we performed GSEA of EBF3 and found great enrichment in the glycolysis/gluconeogenesis metabolic pathway (Fig. 3A).

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PMC11377827

Surprisingly, the USP43 mutant also partially restored HIF reporter activity and CA9 levels (Fig. 4F–I), suggesting that while USP43 enzymatic activity may be involved, deubiquitination itself was not essential for the effect of USP43 on HIF-mediated transcription.

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PMC9688728

F-ratio is calculated as the ratio of class-to-class variation to within-class variation.

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PMC9080589

Therefore, blocking Wnt/β-catenin signaling pathway could suppress metastatic potential and tumorigenesis in PTC.

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PMC9429973

Although some RNA molecules, especially non-coding RNAs, were reported to modulate transcription in leukemia cells, the regulatory role of genome-wide RNAs on transcription through chromatin association remains largely unexplored.

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PMC9856122

Similarly, HIV is also a major health concern worldwide.

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PMC7342409

Imatinib had a weak inhibitory effect on the growth of GIST882-ir cells, while CQ had no effect on the growth of GIST882-ir cells.

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PMC11795610

During the differentiation of keratinocytes induced by 1.8 mM Ca, myricetin could inhibit keratinocyte growth, and promote cell cycle arrest.

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PMC10204952

After incubation, the cells were first fixed in 4% paraformaldehyde for 20 min and rinsed with 1X PBS twice.

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PMC11768927

To counteract resistance observed in specific tumor subpopulations or metastatic lesions, numerous studies have integrated inhibitors of cellular resistance with VSV treatment.

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PMC11013014

Drug-likeness parameters were calculated in silico using the SwissADME web server .

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PMC11753435

Top 1 accuracy is the likelihood that for a given protein, the model has chosen the correct binding peptide, and top 10% accuracy is the likelihood that this peptide is in the top 10% of peptides when ranked for the CLIP score to this protein.

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PMC11687167

The expression of PCSK9 dependented on the kinase pathways of JAK1/2 and MEK1 (mitogen-activated protein kinase kinase 1)/ERK.

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PMC11590870

The samples from selected three-year-old plants were harvested and taken into the laboratory.

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PMC8382973

The toxicity of HEC against TZM-bl cells was measured using a CCK-8 assay kit.

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PMC11412721

With this strategy, we obtained puromycin-resistant clones from Raji cells, two of which were verified to be ACKR4 KO clones by DNA sequencing (Figure 4—figure supplement 3).

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PMC9429973

M. Rodríguez, J. Cornago, J. Serrano, R. Alonso Alonso, D. Morillo, M. A. Perez Saenz, J. M. Alonso Dominguez, M. A. Piris, J. Sánchez García, P. Llamas Sillero, J. Serrano Lopez Pathology, IIS-Fundación Jiménez Díaz, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC); Hematology, Fundación Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, UAM, Madrid; Hematology, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Cordoba; Experimental Hematology Lab, IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain Background: Activated B-cell (ABC) lymphomas emerged as a distinct molecular subtype within Diffuse Large B-Cell Lymphoma (DLBCL).

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PMC9429973

The blood film was revised for assesment of platelet size and morphology.

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PMC10376064

We extracted total protein from the brain and first quantified aggregated Aβ42 in the guanidine-soluble fractions (Figure 5A,B).

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PMC9429973

104 AEs were recorded, of which G1 45%, G2 32%, G3 22% and G4 1%.

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PMC8735881

Similar to their inhibitory activities on replication-competent HIV-1 isolates and pseudoviruses, GPI-scFvs also exhibited different degrees of breadth and potency in blocking cell–cell fusion mediated by a panel of primary HIV-1 Envs with diverse subtypes and phenotypes (Table 1).

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PMC10870498

Nevertheless, the specific regulatory mechanism of succinylation in ATC remains unclear.

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PMC11593084

Similarly, LpMab-2-based CAR-T cells killed patient-derived glioma stem cells and suppressed the growth of a glioma xenograft in immunodeficient mice .

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PMC10743717

that the reported kinetic constants (see the right column of Table 2 reproduced from Ref. )

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PMC9429973

The safety, tolerability, recommended dosing, immunogenicity, and antitumor activity of A+AVD have not previously been evaluated as a first-line therapy in treatment-naïve pediatric patients with cHL.

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PMC11228511

The detection of NM ruptures was performed as previously described (21).

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PMC11506670

Expression of the wild-type and mutant NRAS proteins was confirmed via Western blot analysis (Supplementary Figure S1), following the protocol described below.

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PMC11680562

Subsequently, the aqueous drug solution and CuO NPs suspension were introduced into the polymer solution, followed by the addition of a CaCl2 solution (Fig. 4).

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PMC9429973

Demographic, standard laboratory and AML-related parameters (blood/bone marrow blast percentage, cytologic, flow cytometry and genetic markers enabling ELN risk stratification were collected from patients’ health records.

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PMC9429973

The primers recommended by Europe Against Cancer Association (EAC) and widely used (including as part of commercial diagnostic kits) flank 687bp ABL1 gene DNA fragment.

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PMC7642379

For finding differentially expressed pathways of genes between adherent and suspension cell lines, we used the Wilcoxon statistical test and filtered gene sets with adjusted p-value lower than 0.05 as significantly changed.

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PMC11792888

Scorpion venom was eluted at 1 mL/min flow rate using a linear gradient of 0-45% of solvent B for 45 min.

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PMC8922418

We noticed that the natural CXCR4 P191A mutant could inhibit X4 tropic HIV-1 infection without impairing HSC differentiation (Liu et al., 2014).

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PMC8584319

Next, we investigated the role of MAPKs in AZD8055-mediated inhibition of protein synthesis.

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PMC9509578

Bahadur et al. synthesized poly (2-)pyridine-2-yldisulfanyl)ethyl acrylate) (PDS) nanoparticles loaded with doxorubicin and decorated with a cRGD peptide and observed their stability and drug release in both acidic pH and redox potential conditions in colon cancer HCT-116 cells.

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PMC9429973

Aims: To report results from the 9-week follow-up visit after the last sutimlimab dose in the CARDINAL study.

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PMC5173112

As expected, decreased binding of USP21 to the promoter regions of IL-8 was associated with increased uH2A level and decrease of H3K4me3 levels (Figure 7B and 7C), confirming the function of USP21 in regulating the transcriptional activities of IL-8. (

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PMC11699465

All the cells were identified by STR.

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PMC9031474

Cinnamodial (7) was less cytotoxic than capsicodendrin (8).

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PMC11767817

Protein expression was analyzed after 8 h of incubation, and results are presented in Figure 2 and Figure S3.

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PMC11321678

A CCAN linked OTX2, whose amplifications are enriched in Group 3 and is identified as super‐enhancer‐associated genes in MBs, exhibits the strongest specificity in Group 3 clusters as well as HLX (Figure 2D; Figure S5A,B, Supporting Information).

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PMC11632064

10.2.3 (GraphPad) or the Microsoft Excel software.

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PMC11697189

Except for tumor cells, the other two main components in the tumor microenvironment are immune cells and stromal cells.

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PMC11549612

The impact of BOLA1, BOLA2, and BOLA3 expression on molecular and immune subtypes of KIRC was explored using the TISIDB website.

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PMC11519567

In all, 1× Hoechst33342 reagent was used to counterstain the nucleus.

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PMC11222184

The performance of the analysis was assessed by p value and q value.

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PMC9429973

Pts could receive a second course of CTX130 if response was not achieved but had experienced clinical benefit or disease progression.

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PMC7305184

Graphical description of the experiment is presented in Fig. 5.

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PMC11659734

An in vitro chromosomal aberration assay was performed to evaluate the potential of BPE to induce structural chromosomal damage in human lymphocytes.

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PMC9429973

Of 70 who were infected, 65 reported their PC change with A PC drop in 21 (32%).

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PMC10728200

Total RNA was extracted using Trizol (Yeasen Biotechnology Shanghai, China) and reverse-transcribed into cDNA.

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PMC11011837

Metabolomics and lipidomics are emerging fields of biochemistry that study metabolic pathways and metabolic processes in a biological system .

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PMC11371747

Representative figure from three separate experiments (SEM was within the size of the marker). (

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PMC11139449

It predicts binding sites across the entire genome by comparing the gRNA sequence with the target genome, helping detect regions where genetic alterations may occur ( 26 ).

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PMC2193049

To address this question in greater detail, we isolated human proteasome and performed in vitro digestion studies using synthetic peptides.

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PMC11424574

Low: low expression of MTA2; High: high expression of MTA2.

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PMC11697189

ROC curve analysis showed the prognostic accuracy of risk signature and other clinical features. (

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PMC8270637

The present findings revealed that TGF-β1 attenuated the killing effect of T cells on SMMC-7721 and Bel-7404 cells.

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