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PMC9964654
One of the main goals of nanomedicine is to develop targeting delivery systems with the ability to reach pathological sites in the body, such as tumors.
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PMC11240448
For each , we ran an 8-fold CV iteratively for 1000 repetitions.
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PMC11791203
Fig. 6(A) Three dimensional docking interaction images of 1,2-benzenedicarboxylic acid, Cyclododecanol, 2,4-Ditert-Butylphenol and Sulfurous acid, hexyl octyl ester onto Caspase 3. (
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PMC11806818
Table 2Single-mode aptamer biosensors based on nanozymes for cancer cell-derived exosomes detectionCell LineAptamerNanozymeSubstrateDetection MethodLinear RangeLODRecovery(RSD)Assay TimeRef.
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PMC9429973
A. Spira, L. Liao, X. Zhou, A. Gnanasakthy, L. Chen, D. Ungar, E. Yu, T. Kilavuz, J. Radford, M. Hamadani Virginia Cancer Specialists Research Institute, Fairfax, VA; ADC Therapeutics America Inc., New Providence, NJ; RTI Health Solutions, Research Triangle Park, NC, United States of America; NIHR Clinical Research Facility, the Christie NHS Foundation Trust and University of Manchester, Manchester Academic Health Centre, Manchester, United Kingdom; Medical College of Wisconsin, Division of Hematology & Oncology, Milwaukee, WI, United States of America Background: Loncastuximab tesirine (loncastuximab tesirine-lpyl; Lonca) has shown antitumor activity with an acceptable toxicity profile and provides stable or improved health-related quality of life (HRQOL) in adult patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) after ≥ 2 prior therapies.
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PMC9118379
More detailed results about the diversity of SSe-gFDR versus CMSe-gFDR are provided in Table S3.
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PMC5261804
Highly essential interactions of CTNNB1 in descending order were those with SRC, RAC1, JUN, PTPN11, HDAC1, EGFR, RHOA, CTNNA1, CDC42, and AR.
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PMC11473843
The identification of these mechanisms will provide information about the required feedback loops leading to FAK inhibitor resistance.
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PMC11720107
The colorimetric product was then measured.
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PMC7171147
Recent studies have shown that blocking of FAO inhibits tumor cell proliferation and induces apoptosis in leukemia, myeloma, glioma, glioblastoma, prostate, breast, and ovarian cancer.
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PMC11659921
Finally, we investigated the binding affinity between TNFSF11 and angiogenesis‐targeted drugs through molecular docking, revealing that both drugs included in the analysis displayed strong binding capabilities to TNFSF11 (Figure 8F–H).
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PMC6487404
Intestinal absorption, which is usually influenced by various uptake and efflux membrane transporters in the intestine and/or liver, is an important key factor affecting the oral bioavailability of medications (3).
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PMC10729469
Table contains p-values for slopes and intercepts of compared linear regression analysis (n = 3).
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PMC10197932
On the other hand, we demonstrated, for the first time, that ultrasound not only does not affect healthy CD3/CD8 lymphocyte viability, but their functions and activation are fully preserved, suggesting the absence of any genotoxic effect after US-treatment; furthermore, we demonstrated that in our experimental condition, different leukemic cells, which differ in their lineage and genotypes (AML or ALL cells), could be affected differently by US treatment.
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PMC9429973
Treatment-related toxicity was mainly infectious (39%) and hematological (24%).
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PMC6835428
Based on these and other molecular features, a classification of the cellular models that best resemble HGSOC has been proposed .
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PMC11627133
Notably, RNA aptamers are easily synthesized in vitro and cost‐effective in comparison to antibodies, with the added advantage of genetic encodability, enabling their application in living cells.
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PMC9503685
As non-peptide mimics of AMPs, ceragenins offer comparable mechanisms of bactericidal activity without the accompanying complexity or susceptibility to proteases.
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PMC11747885
It is likely involved in forming key hydrogen bonds with critical amino acids in the active site of Rlig1-AMP, potentially within the RNA binding pocket.
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PMC11723947
To do so, we selected differentially expressed genes and ran multiple WGCNA.
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PMC11698348
No specific staining was observed.
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PMC11686380
To date, six cases harboring GAP43 gene abnormalities have been reported to present with neurodevelopmental diseases, including ID, attention deficit, motor neuron disorders, and skeletal abnormalities (Table 1).
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PMC9429973
No statistically significant correlation with other immune cell subsets, including macrophages, CD4+ T or T regulatory cells were identified.
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PMC11295144
Scale bar = 20 μm.
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PMC9964635
Compound 2 was slowly refluxed at 76 °C for 3–4 h with hydrazine hydrate in CH3OH and yielded 2-(4-isobutylphenyl)propane hydrazide (3).
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PMC10006224
To analyze total proteins, unextracted cells were fixed in ice-cold 70% ethanol for 2 h. To eliminate antibody staining variation among samples from different conditions, a barcoding strategy was used.
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PMC5363531
On the contrary sequential treatments, at 100 nM, led to TS downregulation (r = rD; m = mD) (C).
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PMC11703992
CD4+ Memory T cells were subsequently divided into gene-positive and gene-negative groups, then further single-cell analysis was conducted.
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PMC9429973
CAR engraftment was observed in 13/13 patients evaluated by qPCR with ongoing persistence in 12/13 patients at last follow-up.
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PMC11739504
The black dotted line defines the area of the dilated tubule.
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PMC7053076
As a positive control Raji nuclear extract was added.
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PMC11777207
To address whether a trans interaction was sufficient to promote DC migration, we cocultured LPS activated Pdl1 BMDCs with Cd80 BMDCs (fig. S8A).
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PMC11300639
Transwell-invasion assays were performed using 8-μm pore BioCoat Matrigel Invasion chambers (Corning, USA).
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PMC11248911
The training process is ended when further descriptor inclusion does not enhance the model quality (does not decrease RMSECV anymore).
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PMC11266100
These results might be explained due to the absence of Ca ions in the No. Five EP buffer composition, which is reported to play a crucial role (Suzuki et al., 2003; Ciobanu et al., 2018; Shi et al., 2022; Li and Shaw, 2023).
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PMC11610461
A: cell staining intensity was calculated as 0 (negative staining); 1 (weakly positive staining); 2 (moderately positive staining), and 3 (strongly positive staining).
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PMC11604015
The reasons for efficient proliferation and persistence of these donor-derived CAR-T cells may be discussed in two aspects.
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PMC11726848
Regarding the cell, fate is determined by the competition of cell damage and the functioning of repair systems, and cell cycle arrest can occur after exceeding a threshold in DNA damage; we assume that this threshold is not exceeded in the case of LDR irradiation.
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PMC11087055
The white asterisks indicate GFP-expressing cells. (
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PMC11775197
Subsequent reports have corroborated the assertion that heightened awareness of TME, the most significant obstacle, will enhance the efficacy of CAR T cell therapy in solid tumors .
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PMC11046454
Flow cytometry analysis of PTK7 overexpressed K562 cells after incubation with CAR-T, Lib-CAR-T, or AptPTK7-CAR-T. T cells were prestained with SiR-Actin kit. (
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PMC11585994
To evaluate its stability, G5-sgc8-siBCL11B was incubated in media containing 10% and 100% FBS for up to 72 hours, during which DLS and zeta potential measurements were monitored (Figure 1F–G).
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PMC10808409
Moreover, the presence of hydrophilic polymers in both O1 and O2, speed up the water uptake causing micelles erosion and consequently diffusion of the drug.
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PMC10858941
Three-dimensional microfluidic models, based on the organ-on-chip concept, emerged as a solution to address these limitations.
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PMC11469524
Eq (2)).
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PMC11519077
Recent researchers have found that IL-6 suppresses p53 expression and activity by stimulating ribosomal ribonucleic acid (rRNA) transcription in proliferation factors and promoting mouse double minute 2 homolog (MDM2)–mediated p53 proteasome digestion .
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PMC7338939
Significant Values marked in bold P < 0.05.
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PMC11779605
ELISA measurement of FGF7 protein in initial ES-2 orthotopic model of ovarian cancer compared using a paired t-test; (C) ELISA measurement of FGF7 protein in independent orthotopic ES-2 model of ovarian cancer compared using an unpaired t-test. (
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PMC11787651
C, area of H3K27ac peptide observed in each control and TGF-β treated sample by method and injection amount.
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PMC8170755
The IC50 was determined using GraphPad Prism software version 7.03.
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PMC10887351
These studies were confirmed by the proof that muscle relaxation in pre-contracted samples could not be induced only with β3-AR agonists rather than β1- and β2-AR agonist stimulation.
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PMC3734024
Splenocytes from cII-TCR transgenic mice were collected and cultured with Concanavalin A. After three days, activated CD4 T cells were then negatively-selected by MACS and co-cultured at a 1∶1 ratio with B cells in the presence or absence of cognate peptide.
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PMC9822769
The same was true for 1 and 3 (data not shown).
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PMC10777969
The growth mediums were supplemented with glutamine (Lonza, Walkersville, MD, USA), 10% fetal bovine serum (BioWhittaker, Lonza, Walkersville, MD, USA), and 1% penicillin–streptomycin mix (Sigma-Aldrich, St. Louis, MO, USA) of the total volume (v/v).
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PMC9429973
Furthermore, combination treatment (41 days) significantly prolonged survival compared to single MRK-560 (34 days), dexamethasone (30 days) or placebo (16 days) treatment.
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PMC11144382
Antibodies against GAPDH (37 kDa) were used as loading control.
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PMC7887261
The top five candidate variants (red arrows): 1) POMC c.*28 deletion (del) located at target sites of several miRNAs in 3′ UTR; 2) STAU2 p.N364M fs*67del located in the double-stranded RNA-binding motif (dsrm), and next to a phosphorylation site p.S363; 3) ATM V2716A located in the PI3-kinase (PI3K) catalytic domain; 4) MPZL2 p.I24M fs*22del was close to the antibody variable domain of immunoglobulins (Ig-V); 5) MLNR p.Q334V fs*3del located in the transmembrane receptor domain (TM), and close to a phosphorylation site p.S327.
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PMC11429241
Scaffold-based 3D culture fabrication techniques range from 3D-extrusion-based printing to electrospinning .
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PMC9429973
In the phase 1/2 MajesTEC-1 trial, initial results from the pivotal cohort (patients who received ≥3 prior lines of therapy [LOT], including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody) showed that teclistamab was well tolerated with encouraging efficacy.
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PMC11290772
The ROBO1-CAR sequence was introduced into the NK cells, followed by purification of the ROBO1-NK cells through flow cytometry separation.
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PMC10674574
The BA of a drug after oral administration is largely determined by the drug’s dissolution rate, its solubility characteristics in gastrointestinal fluids, and its permeability across biological membranes (intestinal permeability) .
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PMC11789597
Error bar, mean ± SD. ,
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PMC11381192
We initially developed five distinct cellular stress indexes that were highly interrelated and significantly predictive of patient outcomes.
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PMC10706275
The CHO cells can be cultured in a serum-free medium with minimal chemical composition.
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PMC9479186
Compared with patients with low NDUFC1 expression, patients with high NDUFC1 expression had a poor prognosis, and high NDUFC1 expression was the independent risk factor for survival.
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PMC10123657
Moreover, the mass spectrometer was operated in the data-dependent acquisition mode, which is biased to pick peptides with the strongest signal, most likely coming from the predominant human cells.
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PMC11320834
Liposome size and zeta potential were measured at 37 °C using a Zetasizer Nano ZS (Malvern Instruments Ltd., UK) by dynamic light scattering (DLS) and laser Doppler velocimetry, respectively.
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PMC11782780
Our study demonstrated that EBF3 was a direct downstream target of miR-301b-3p.
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PMC6379402
This network model, which is based on preferential attachment principle, is characterized by a scale-free degree distribution, i.e., the SF networks have the degree distribution that follows a power law.
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PMC11637276
Upon knockdown, β1-integrin intensity was significantly reduced, indicating successful protein knockdown upon siRNA transfection (S2F Fig).
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PMC3681794
Cells were allowed to adhere for 24 hours, the medium replaced and flasks incubated in hypoxia or normoxia for a further 24 hours.
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PMC9429973
We also employed another ITP cohort (N = 127) to validate the significant results of SNPs found in the discovery cohort.
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PMC11394386
Notably, these findings were replicated in patient-derived xenograft models, underscoring the feasibility of this approach.
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PMC11736898
ANOVA analysis of variance We next examined the effects of inhibition of CYP24A1 enzyme activity on gene expression in normal and keloid keratinocytes.
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PMC11243198
Our evaluation of the molecular docking prediction of BAS 07019774 binding to the human GLI1-ZF domain showed the best pose consisted of three interactions: one hydrogen (H)-bond with Arg348 and two π-acceptor H-bond interactions with the hydrogens of His335 and Glu334.
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PMC10955424
Crizotinib is an ALK, ROS1, and c-MET inhibitor that has been approved by the FDA in treatment of several human cancers .
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PMC10809689
Fig. 7Changes of glutamate level in control, PMA, and PG72 samples of HL-60 cell line and RP-HPLC chromatograms.
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PMC11204465
The construction of the tricyclic framework was then completed by esterification, followed by the removal of the benzyl-protecting group, resulting in the tricyclic intermediate A-5.
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PMC9780037
In the other biosensor, the fluorescence decrease associated to cyt c binding is more pronounced at higher temperatures .
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PMC11387401
But we can confirm that Gag binds numerous host RNAs, potentially driven by its Nucleocapsid domain, as the majority of identified Gag interactors are shared with the NC subunit (Fig. 3).
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PMC9014716
There were some limitations to this study.
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PMC9429973
Proportions of patients who experienced clinically meaningful HRQoL deterioration and improvement were calculated using prespecified responder definitions.
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PMC8041314
Our aim was to define unambiguous selection criteria, or at least as close to this as possible.
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PMC11052306
Several other series of phosphorus dendrons with diverse functions at the core and pyridyl–imine/hydrazone derivatives as terminal functions (Figure 2, but without metal) were synthesized (Figure 10).
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PMC7081114
HCC cell lines Hep-G2, BEL7402, BEL-7404, and SMMC-7721 and the normal liver cell line Chang liver were purchased from Shanghai Genechem Co., Ltd. (Shanghai, China).
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PMC11770199
Female C57BL/6J mice were injected subcutaneously with 5 × 10 mouse colon cancer cells of MC38 in the right leg.
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PMC11693599
Similar to ovarian cancer cell line-derived CSCs, CD109 was highly expressed in pOCs, as shown by western blotting (Fig. 3B).
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PMC11699042
Outer violin curves denote the kernel density.
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PMC6684588
P ≤ 0.05, ***P ≤ 0.001 vs. vehicle by one-way ANOVA with Dunnett’s adjustment. (
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PMC11770130
The pair-feeding experiment in a staggering manner was performed according to the published protocols.
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PMC11705862
Semi-quantitative PCR (with GAPDH as internal reference) also confirmed significant downregulation of IRIS-1 and IRIS-2 mRNA expression levels upon treatment with elevated glucose, palmitic acid, and proinflammatory cytokine TNF-α, as shown in (Supplementary Fig. 5A, quantification in S5D) for IRIS-1, and in (Supplementary Fig. 5B, quantification in S5E) for IRIS-2 transcript.
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PMC9429973
Follow up and treatment data were available for 570 and 534 ptn, respectively.
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PMC11802929
These observations suggest that the biochemical nature of the TCR:pMHC interface may play an important role in determining T cell phenotype and cell fate trajectory.
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PMC11615218
In contrast, the 4-1BB domain was found to activate both glucose and fatty acid metabolism via the liver kinase B1-AMP-activated protein kinase-acetyl-CoA carboxylase signaling pathway, and it also promotes mitochondrial biogenesis through the PGC1α-mediated pathway .
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PMC8992508
Structural features for inhibitory activity against BCRP were identified, like the presence of a quinazoline 2-phenyl ring bearing two methoxy groups and the presence of the 3,4-dimethoxy substituent on chalcone ring B, which caused an increase of inhibitory activity.
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PMC11699465
Besides, epigenetic regulation is also essential for modulating PD-L1 expression.
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PMC10213199
In addition, HERB screened 1241 novel genetic targets for 473 herbs and 494 modern diseases from 1966 recently published articles.
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PMC11727062
Furthermore, Garcinia cambogia has been associated with certain toxic side effects in clinical use (Zhao et al. 2010).
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PMC10142392
According to these results, poly (caprolactone) (PCL) has shown remarkable effectiveness for use as a biomaterial in scaffolds intended for tissue engineering, as well as for absorbable sutures, dressings, and anti-adhesion barriers, because it can adapt to different production methods.
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PMC11269933
After confirming the normality of the distributions using the Shapiro–Wilk test and homogeneity of variance using Bartlett’s test, data were analyzed with the two-tailed unpaired Student’s t-test, one-way analysis of variance (ANOVA) and two-way ANOVA followed by Tukey’s multiple comparisons test.
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