PMCID string | Sentences string | ner list |
|---|---|---|
PMC11127909 | As directed by the manufacturer’s protocol, apoptosis of OS cells was measured in paraffin-embedded OS samples using a One Step TUNEL Assay Kit (Beyotime; #C1086). | [
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PMC11766332 | This investigation yielded a list of statistically over-represented biological pathways for each ASD-miRNA included in this study (Figure 1A,B). | [
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PMC10253553 | We hypothesize that RICTOR could stimulate NDRG1 protein stability by associating with NDRG1 in a complex that does not contain mTOR. | [
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PMC11627060 | These data allow for the comparison of the cytotoxic efficacy of the NPs against a recognized chemotherapeutic agent. | [
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PMC11457557 | An increasing body of research points to the importance of genetic predisposition in the onset of both diabetes and diabetic vascular complications. | [
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PMC11612315 | His-tagged exendin 9–39 was bound to HisPur Cobalt Resin as the bait protein and incubated with lysates of hTRPV1-CHO K1 or native CHO K1 cells overnight at 4 °C. | [
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PMC11607638 | Receptor structural works will help to search for an effective drug‐binding site for selective insecticide. | [
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PMC9429973 | All 50 donors were HLA-matched, and 8 (16%) were HLA-matched unrelated (MUR). | [
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PMC11585565 | The 3D structure analysis of CNNM2 protein with Mg-AMP-PNP (used as a substitute for CNNM4 due to the absence of 3D structure with Mg-ATP analogue) identified residues Phe457, Thr479, Arg480, Thr568, and Asp571 of CNNM2 protein, corresponding to Phe384, Thr406, Arg407, Thr495, and Asp498, respectively, in CNNM4 protein... | [
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PMC11248911 | On the other hand, the potential derivative 8 showed no PAINS alerts recording 0.55 bioavailability value and was categorized as non-carcinogenic substance. | [
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PMC11519567 | Supernatants were subjected to SDS–PAGE and incubated with corresponding primary antibody(Anti-DYKDDDDK tag, AlpHcAbs® Rabbit antibody, Code: 016-203-001; H2AK119ub, CST, #8240) and secondary antibodies(HRP-labeled Goat Anti-Rabbit IgG(H + L), Beyotime, A0208). | [
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PMC11725127 | Relative mRNA levels of USP2 in PBMC and primary myeloma cells (n = 6). ( | [
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PMC9429973 | Such transient monosomy 7 was recently associated with germline mutations in sterile alpha-motif domain-containing protein 9 (SAMD9) and its paralog SAMD9-like (SAMD9L), both located on chromosome 7q. | [
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PMC7504302 | Despite the negative results with earlier antiangiogenic therapies, newly designed clinical studies targeting VEGF and other growth factor signaling pathways, alone or in combination, are underway . | [
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PMC9429973 | A colony formation assay showed that Nos2 deficient bone marrow cells isolated from mice treated orally with HU (200mg/kg) formed significantly more erythroid colonies (BFU-E and CFU-E) and granulocyte/macrophage progenitors (CFU-GM) compared to HU treated wild-type and untreated Nos2 null mice showing the involvement ... | [
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PMC11391695 | And there were no obvious nodules and necrosis in the organs of mice, indicating that the nanoparticles encapsulated in tumor cell membranes were not organ toxic. | [
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PMC11087055 | To address relationship(s) between the polonaise movements and the shape of the PS, we live-imaged the control- and ΔDEP-GFP-embryos from pre-streak stage to HH3 and analyzed the resulting cell flows (Figure 1G–L”’, and Video 1). | [
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PMC9429973 | Further study of the MAGE-C1 gene may allow to determine the tactics of induction therapy already at the diagnostic stage. | [
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PMC11635087 | Chloroplasts are photosynthetic organelles that evolved through the endosymbiosis between cyanobacteria-like symbionts and hosts. | [
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PMC10631132 | Downstream of the GMP or MLP a CD11bCD34c-KITFLT3IL3Rα population was identified as a common macrophage, OC and dendritic cell progenitor that was mRNA positive for CSFR1, but did not show any presence of CSFR1 at the cell surface . | [
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PMC11792766 | These NOAEC values were then used to establish food simulant concentrations at which no background effects are observed via the bioassays. | [
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PMC11046454 | CD3 T cells were isolated from human peripheral blood mononuclear cells (PBMCs, Figure S14) and transfected with anti-FITC CAR (the resultant T cell was termed CAR-T). | [
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PMC11574271 | D The migration ability was tested by wound-healing assay. | [
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PMC7602170 | Li and colleagues showed that PI3K/AKT/mTOR signaling was inactivated due to FANS knockdown, especially with the attenuation of the activation of RPS6 and 4E-BP1, leading to the inhibition of proliferation and migration in GIST cells . | [
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PMC11411004 | HDAC, histone deacetylase, mRNA; siHDAC5, small interfering RNA of HDAC5. | [
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PMC11591794 | Researchers argued that it may be due to the excessive production of ROS by GA, which triggers proliferation inhibition and plays an active role in stopping the G2/M phase, and the chemotherapy agent Paclitaxel triggers extracellular signals . | [
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PMC11723947 | b–d Percentage of WT or HP1α KO TCR Vβ6CD4 T cells producing IFN-γ (b), IL-17A (c) or both (d) 21 days after engraftment. | [
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PMC11754784 | Erythrocytes in the blood samples were pre-removed by gradient centrifugation (800 × g) and leukocytes were washed the sample three times with DPBS. | [
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PMC11033180 | Whether this dual activity of Sema5A also relies on its molecular form as a membrane-bound or secreted proteolytic-cleaved protein, as shown for Sema5B in synapse elimination remains to be determined. | [
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PMC11519077 | Mononuclear cells were separated using Ficoll-Paque (Lymphodex, Innotrain, Germany) and density-gradient centrifugation as directed by the manufacturer. | [
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PMC11765243 | As shown in Figure 1C,D, the number or the frequency of CD4CD8 DN subpopulations did not show significant alterations, confirming the CD4 linkage of p110α mutation in this model. | [
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PMC10976516 | Patients with early-stage illness are also advised to have radiation therapy to the brain. | [
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PMC11733919 | Furthermore, to predict the response of A431 cells to apoptotic stimuli, a comprehensive analysis of gene mutations in genes related to apoptosis was conducted (Figure S8). | [
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PMC10291556 | The antiproliferative activity of the new compounds toward cancer cells was tested in a panel of six human cancer cell lines. | [
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PMC9429973 | Methods: Unicentric retrospective review of GvHD pts who started Ruxo from January 2019 to August 2021. | [
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PMC11092382 | In addition, sophocarpine is an ideal starting material for drug synthesis and structural modification due to its unique chemical structure with an α,β-unsaturated carbonyl group, which may provide a flexible reactive site for nucleophiles (Hu et al., 2010). | [
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PMC9436459 | M. yunanensis), M. nigra, M. notabilis, M. wittiorum, S. bonplandii, and S. ilicifolia Type B: Dehydroprenylstilbene type MDAAs 19 compounds (58 − 76) distributed in ten species: C. regia, M. alba, M. bombycis, M. cathayana, M. lhou, M. macroura, M. mongolica (syn. | [
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PMC11023271 | The A431 cell line was purchased from ATCC (cat# CRL-1555). | [
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PMC10890055 | After 1 h of incubation, the fluorescence was measured at 560/590 nm (excitation/emission) (Fluoroskan Ascent FL, Thermo, or Spectramax id5, Molecular Devices). | [
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PMC11700165 | Samples were prepared for Western blotting as described previously. | [
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PMC9429973 | The increase in the life expectancy of CLL patients was greater than in the general population. | [
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PMC11790971 | The phasor analysis provided three additional channels (i.e., phasor g, phasor s, and phasor mean lifetime). | [
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PMC9429973 | Results: Analysis of BL tumor biopsies showed all pts were CD20 positive (range: ~35–98% CD20+ PAX5+ B cells) and CD20 levels were not associated with response. | [
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PMC11752740 | Furthermore, the combined treatment group exhibited a greater reduction in NF-κB p65 protein levels compared to the individual treatment groups (indicated by the c symbol). | [
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PMC7823217 | These studies could further pave the way for bioprinting of multicellular patterns with patients own heterogenous cancer cells as a platform for testing chemotherapeutic agents and hence the development of personalized therapies . | [
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PMC11757131 | Anti-CPT1, anti-ACSL, and anti-CAD antibodies were purchased from Proteintech (Proteintech Group, United States). | [
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PMC9964635 | Docking experiments for all of the scaffolds were carried out in order to comprehend the potential interaction process of the synthesized anti-cancer compounds on the HepG2 cancer cell line. | [
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PMC9429973 | The fatality rate (FR) decreased from 40.3% (50 out of 124) in the first two quarters of year 2020 to 15.8% (3 out of 19) in the first two quarters of year 2021 (p<0.05). | [
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PMC11707577 | Validation of M13EGFR(TNP) targeting on A431 cell line. | [
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PMC9250505 | A total of four treatment groups were tested in 6 PDXs respectively. | [
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PMC11705067 | The correlation of FDX1 and DLAT genes with immunosuppressant checkpoints in pan-cancer were shown in Fig. 7A, 7B. | [
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PMC11200978 | Sixth, combination studies were limited to evaluating a single chemotherapeutic agent, gemcitabine, in an effort to establish evidence of the benefit combinatorial cryo/chemo treatment for LC. | [
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PMC11279598 | MH’s unique composition, including phenolic compounds and methylglyoxal, has been reported to have antioxidant, antiseptic, and anticancer properties. | [
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PMC11413393 | Despite recent advancements in high throughput sequencing technologies, the epigenomic profiling of arginine histone substrates has remained an outstanding challenge owing in part to a lack of high quality, validated antibodies against arginine-methylated histones. | [
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PMC10218459 | As a control, a similar treatment with the carrier solution DMSO was carried out. | [
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PMC9429973 | Furthermore, healthy patients (n = 8) were included as controls (C). | [
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PMC10243817 | A total of 117 controls, 118 patients with eosinophilic CRSwNP, 113 patients with noneosinophilic CRSwNP, and 103 patients with CRSsNP were enrolled in this study. | [
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PMC5417661 | The plasma levels of NOV202 were determined after PO administration at 1 and 4 h post-dosing. | [
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PMC11754784 | Besides, the concentration-dependent non-specific cell binding was negligible, as demonstrated by flow cytometry (Supplementary Fig. 7). | [
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PMC11545868 | When Fas binds to its Fas ligand (FasL), which is normally expressed on the surface of cytotoxic T cells, it triggers a signal transduction cascade within the cell. | [
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PMC10761571 | The use of nanotechnology products with supermagnetic properties for targeted delivery of drugs has gained attention recently. | [
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PMC10125312 | Effect of AuNR-PEG concentration on cellular viability. ( | [
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PMC11546117 | Briefly, PMC42-LA cells were cultured in RPMI-1640, with addition of 10% FBS and 1% penicillin/streptomycin. | [
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PMC11627060 | For instance, the intrinsic pathway typically involves mitochondrial damage, whereas the extrinsic pathway relies on receptor–ligand interactions . | [
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PMC9583612 | The CHIPS and Science Act authorizes the establishment of a Center for Greenhouse Gas (GHG) Measurements, Standards, and Information to improve spatially and temporally resolved GHG measurements. | [
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PMC9429973 | SPSS22.0 and GraphPad Prism 8 were used to analyze the data. | [
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PMC11765988 | A recent meta-analysis reported an overall RR of 3.67 (2.92–4.63) for lymphoma in patients with sarcoidosis . | [
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PMC11754094 | The infected cells were selected with puromycin and transfected with Cas9 RNP complex targeting the puromycin resistance gene using electroporation. | [
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PMC11119602 | Whereas the total mRNA levels of TG2 in HepG2/cr were approximately 50% of those of parental cells, this reflected changes in TG2-L and not in TG2-S protein levels, which stayed approximately constant (Figure 2A,B). | [
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PMC11643361 | complexes with similar ligands (66–69, Figure 7) were also studied for their cytotoxic effects against ovarian cancer (A2780), cisplatin-resistant (A2780R), human osteosarcoma (HOS), and colon carcinoma (CaCo-2) cell lines , compared to the standard chemotherapeutics cisplatin, oxaliplatin, and carboplatin. | [
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PMC7185206 | An asterisk (*) denotes moderate to intense staining as scored by a pathologist. ( | [
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PMC11543853 | The tilt series were collected using SerialEM software with a dose-symmetric tilt scheme with an angular range of ±52° (2° increment) or ±60° (3° increment). | [
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PMC11762280 | The statistic of epidermal thickness and average optical density of TUNEL positive staining were analyzed (n = 5). | [
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PMC11694625 | C NMR (101 MHz, DMSO-d6) δ 162.31, 158.11, 150.56, 145.72, 139.41, 137.07, 132.31, 129.49, 128.60, 127.20, 125.35, 122.31, 81.88. | [
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PMC11705484 | Expression of TRMT61A in 5637 cells after vehicle control and/or IκBαS32AS36A treatment. ( | [
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PMC10965315 | The apoptosis of harmaline‐treated A2780 cells was analyzed by flow cytometry. | [
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PMC9780037 | Those alterations can uncover molecules whose concentrations, modifications, and/or subcellular locations are altered. | [
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PMC10728200 | The cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h or treated with IM (50 nM for T1 and 200 nM for 882) for 0, 12, 24, or 48 h. The histograms indicate the levels of the protein determined from 3 independent experiments expressed as the mean ratio relative to that in the untrea... | [
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PMC9429973 | This entity has a good prognosis and its treatment options are very limited, especially for elderly patients. | [
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PMC10203589 | In addition, the IPA-MAP pathway prediction analysis showed that cordycepin inhibited the proliferation of MA-10 cells by inhibiting the FGFs/FGFRs pathway (167). | [
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PMC9429973 | Finally, the presence of 11 patients carrying germlines JAK2 mutations is surprising, and we suppose it will be necessary to strictly watch these patients in the suspicion of a future appearance of a polycythemia vera. | [
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PMC11471157 | The results revealed that DFP supports the adhesion and proliferation of various cell types, including human epidermal cells, human malignant melanoma cells, mouse fibroblasts, mouse endothelial cells and fish fibroblasts. | [
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PMC11706776 | p < 0.05; **p < 0.01; ***p < 0.001 (boxes indicate the first and third quartiles—and the median inside—of the different measures. | [
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PMC11762280 | F Representative photos of mice receiving DSF or vehicle treatment at 48 h after UVB exposure. | [
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PMC11736898 | We found that vitamin D treatment significantly reduced EDN1 expression in keloid keratinocytes but not normal keratinocytes (Figure 7e). | [
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PMC11201245 | The counting of signal constellations that deviated from the diploid pattern resulted in an average of 15.38%. | [
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PMC10919056 | A total of 21 GJPs were observed to be expressed in ccRCC. | [
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PMC11240571 | In the present study, exosomes derived from sarcoma cells inhibited IFN-γ production. | [
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PMC11594074 | The apoptotic trigger is regulated by several upstream and downstream signaling factors, including the BCL-2 protein family. | [
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PMC11267830 | Deletion of THOC1 slows proliferation, increases apoptosis and disrupts the cell cycle in T-ALL cells, ultimately leading to T-ALL cell death T-ALL is a severe malignancy characterized by a high incidence of complications and a poor prognosis . | [
{
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... |
PMC11412721 | We analyzed public databases of B-cell lymphomas patients with clinical and gene expression information. | [
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... |
PMC3164356 | The amplification products from each chamber were retrieved separately. | [
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... |
PMC9822769 | Complex 2 showed an anomalous higher cytotoxicity (similar to that of cisplatin) with respect to their analogues 1 and 3. | [
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"O",
"O",
"O",
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"tokens": [
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PMC10040136 | Further investigation is required to elucidate the specific alterations that occur in MSC within the tumor microenvironment, which confer a drug-resistant phenotype. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"tokens": [
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PMC10551595 | Binding to Cys124 had previously shown a critical role in the restoration of the mutant P53 function. , | [
{
"tags": [
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"O",
"O",
"O",
"O",
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PMC10940855 | Data were analyzed on FACS Diva version 8 and FlowJo version 10 software. | [
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"tags": [
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"O",
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PMC7961460 | Cell lysates were scraped on ice and the protein content was measured using Coomassie Protein Assay kit (Thermo Scientific, Milan, Italy). | [
{
"tags": [
"O",
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"O",
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"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tok... |
PMC11794847 | The immune microenvironment of HVEM KO mice bearing mouse lung cancer cell was also evaluated. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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PMC11759543 | The cell viability analysis was conducted to assess the effect of the combination of doxorubicin and vorinostat on cytotoxicity. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
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"O",
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"tokens": [
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PMC9268183 | The aim of this search was mainly to review the existence of cytotoxic activity tests in cancer cell lines involving the plant species of interest. | [
{
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tok... |
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