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PMC11127909
As directed by the manufacturer’s protocol, apoptosis of OS cells was measured in paraffin-embedded OS samples using a One Step TUNEL Assay Kit (Beyotime; #C1086).
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PMC11766332
This investigation yielded a list of statistically over-represented biological pathways for each ASD-miRNA included in this study (Figure 1A,B).
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PMC10253553
We hypothesize that RICTOR could stimulate NDRG1 protein stability by associating with NDRG1 in a complex that does not contain mTOR.
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PMC11627060
These data allow for the comparison of the cytotoxic efficacy of the NPs against a recognized chemotherapeutic agent.
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PMC11457557
An increasing body of research points to the importance of genetic predisposition in the onset of both diabetes and diabetic vascular complications.
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PMC11612315
His-tagged exendin 9–39 was bound to HisPur Cobalt Resin as the bait protein and incubated with lysates of hTRPV1-CHO K1 or native CHO K1 cells overnight at 4 °C.
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PMC11607638
Receptor structural works will help to search for an effective drug‐binding site for selective insecticide.
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PMC9429973
All 50 donors were HLA-matched, and 8 (16%) were HLA-matched unrelated (MUR).
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PMC11585565
The 3D structure analysis of CNNM2 protein with Mg-AMP-PNP (used as a substitute for CNNM4 due to the absence of 3D structure with Mg-ATP analogue) identified residues Phe457, Thr479, Arg480, Thr568, and Asp571 of CNNM2 protein, corresponding to Phe384, Thr406, Arg407, Thr495, and Asp498, respectively, in CNNM4 protein, as an analogue interacting with Mg-ATP (Fig. 1e).
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PMC11248911
On the other hand, the potential derivative 8 showed no PAINS alerts recording 0.55 bioavailability value and was categorized as non-carcinogenic substance.
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PMC11519567
Supernatants were subjected to SDS–PAGE and incubated with corresponding primary antibody(Anti-DYKDDDDK tag, AlpHcAbs® Rabbit antibody, Code: 016-203-001; H2AK119ub, CST, #8240) and secondary antibodies(HRP-labeled Goat Anti-Rabbit IgG(H + L), Beyotime, A0208).
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PMC11725127
Relative mRNA levels of USP2 in PBMC and primary myeloma cells (n = 6). (
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PMC9429973
Such transient monosomy 7 was recently associated with germline mutations in sterile alpha-motif domain-containing protein 9 (SAMD9) and its paralog SAMD9-like (SAMD9L), both located on chromosome 7q.
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PMC7504302
Despite the negative results with earlier antiangiogenic therapies, newly designed clinical studies targeting VEGF and other growth factor signaling pathways, alone or in combination, are underway .
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PMC9429973
A colony formation assay showed that Nos2 deficient bone marrow cells isolated from mice treated orally with HU (200mg/kg) formed significantly more erythroid colonies (BFU-E and CFU-E) and granulocyte/macrophage progenitors (CFU-GM) compared to HU treated wild-type and untreated Nos2 null mice showing the involvement of Nos2 in the molecular mechanism of HU in vivo.
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PMC11391695
And there were no obvious nodules and necrosis in the organs of mice, indicating that the nanoparticles encapsulated in tumor cell membranes were not organ toxic.
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PMC11087055
To address relationship(s) between the polonaise movements and the shape of the PS, we live-imaged the control- and ΔDEP-GFP-embryos from pre-streak stage to HH3 and analyzed the resulting cell flows (Figure 1G–L”’, and Video 1).
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PMC9429973
Further study of the MAGE-C1 gene may allow to determine the tactics of induction therapy already at the diagnostic stage.
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PMC11635087
Chloroplasts are photosynthetic organelles that evolved through the endosymbiosis between cyanobacteria-like symbionts and hosts.
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PMC10631132
Downstream of the GMP or MLP a CD11bCD34c-KITFLT3IL3Rα population was identified as a common macrophage, OC and dendritic cell progenitor that was mRNA positive for CSFR1, but did not show any presence of CSFR1 at the cell surface .
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PMC11792766
These NOAEC values were then used to establish food simulant concentrations at which no background effects are observed via the bioassays.
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PMC11046454
CD3 T cells were isolated from human peripheral blood mononuclear cells (PBMCs, Figure S14) and transfected with anti-FITC CAR (the resultant T cell was termed CAR-T).
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PMC11574271
D The migration ability was tested by wound-healing assay.
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PMC7602170
Li and colleagues showed that PI3K/AKT/mTOR signaling was inactivated due to FANS knockdown, especially with the attenuation of the activation of RPS6 and 4E-BP1, leading to the inhibition of proliferation and migration in GIST cells .
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PMC11411004
HDAC, histone deacetylase, mRNA; siHDAC5, small interfering RNA of HDAC5.
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PMC11591794
Researchers argued that it may be due to the excessive production of ROS by GA, which triggers proliferation inhibition and plays an active role in stopping the G2/M phase, and the chemotherapy agent Paclitaxel triggers extracellular signals .
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PMC11723947
b–d Percentage of WT or HP1α KO TCR Vβ6CD4 T cells producing IFN-γ (b), IL-17A (c) or both (d) 21 days after engraftment.
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PMC11754784
Erythrocytes in the blood samples were pre-removed by gradient centrifugation (800 × g) and leukocytes were washed the sample three times with DPBS.
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PMC11033180
Whether this dual activity of Sema5A also relies on its molecular form as a membrane-bound or secreted proteolytic-cleaved protein, as shown for Sema5B in synapse elimination remains to be determined.
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PMC11519077
Mononuclear cells were separated using Ficoll-Paque (Lymphodex, Innotrain, Germany) and density-gradient centrifugation as directed by the manufacturer.
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PMC11765243
As shown in Figure 1C,D, the number or the frequency of CD4CD8 DN subpopulations did not show significant alterations, confirming the CD4 linkage of p110α mutation in this model.
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PMC10976516
Patients with early-stage illness are also advised to have radiation therapy to the brain.
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PMC11733919
Furthermore, to predict the response of A431 cells to apoptotic stimuli, a comprehensive analysis of gene mutations in genes related to apoptosis was conducted (Figure S8).
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PMC10291556
The antiproliferative activity of the new compounds toward cancer cells was tested in a panel of six human cancer cell lines.
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PMC9429973
Methods: Unicentric retrospective review of GvHD pts who started Ruxo from January 2019 to August 2021.
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PMC11092382
In addition, sophocarpine is an ideal starting material for drug synthesis and structural modification due to its unique chemical structure with an α,β-unsaturated carbonyl group, which may provide a flexible reactive site for nucleophiles (Hu et al., 2010).
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PMC9436459
M. yunanensis), M. nigra, M. notabilis, M. wittiorum, S. bonplandii, and S. ilicifolia Type B: Dehydroprenylstilbene type MDAAs 19 compounds (58 − 76) distributed in ten species: C. regia, M. alba, M. bombycis, M. cathayana, M. lhou, M. macroura, M. mongolica (syn.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "M.", "yunanensis", ")", ",", "M.", "nigra", ",", "M.", "notabilis", ",", "M.", "wittiorum", ",", "S.", "bonplandii", ",", "and", "S.", "ilicifolia", "Type", "B", ":", "Dehydroprenylstilbene", "type", "MDAAs", "19", "compounds", "(", "58", "−", "76", ")", "distributed", "in", "ten", "species", ":", "C.", "regia", ",", "M.", "alba", ",", "M.", "bombycis", ",", "M.", "cathayana", ",", "M.", "lhou", ",", "M.", "macroura", ",", "M.", "mongolica", "(", "syn", "." ] } ]
PMC11023271
The A431 cell line was purchased from ATCC (cat# CRL-1555).
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PMC10890055
After 1 h of incubation, the fluorescence was measured at 560/590 nm (excitation/emission) (Fluoroskan Ascent FL, Thermo, or Spectramax id5, Molecular Devices).
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PMC11700165
Samples were prepared for Western blotting as described previously.
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PMC9429973
The increase in the life expectancy of CLL patients was greater than in the general population.
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PMC11790971
The phasor analysis provided three additional channels (i.e., phasor g, phasor s, and phasor mean lifetime).
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PMC9429973
Results: Analysis of BL tumor biopsies showed all pts were CD20 positive (range: ~35–98% CD20+ PAX5+ B cells) and CD20 levels were not associated with response.
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PMC11752740
Furthermore, the combined treatment group exhibited a greater reduction in NF-κB p65 protein levels compared to the individual treatment groups (indicated by the c symbol).
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PMC7823217
These studies could further pave the way for bioprinting of multicellular patterns with patients own heterogenous cancer cells as a platform for testing chemotherapeutic agents and hence the development of personalized therapies .
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PMC11757131
Anti-CPT1, anti-ACSL, and anti-CAD antibodies were purchased from Proteintech (Proteintech Group, United States).
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PMC9964635
Docking experiments for all of the scaffolds were carried out in order to comprehend the potential interaction process of the synthesized anti-cancer compounds on the HepG2 cancer cell line.
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PMC9429973
The fatality rate (FR) decreased from 40.3% (50 out of 124) in the first two quarters of year 2020 to 15.8% (3 out of 19) in the first two quarters of year 2021 (p<0.05).
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PMC11707577
Validation of M13EGFR(TNP) targeting on A431 cell line.
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PMC9250505
A total of four treatment groups were tested in 6 PDXs respectively.
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PMC11705067
The correlation of FDX1 and DLAT genes with immunosuppressant checkpoints in pan-cancer were shown in Fig. 7A, 7B.
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PMC11200978
Sixth, combination studies were limited to evaluating a single chemotherapeutic agent, gemcitabine, in an effort to establish evidence of the benefit combinatorial cryo/chemo treatment for LC.
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PMC11279598
MH’s unique composition, including phenolic compounds and methylglyoxal, has been reported to have antioxidant, antiseptic, and anticancer properties.
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PMC11413393
Despite recent advancements in high throughput sequencing technologies, the epigenomic profiling of arginine histone substrates has remained an outstanding challenge owing in part to a lack of high quality, validated antibodies against arginine-methylated histones.
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PMC10218459
As a control, a similar treatment with the carrier solution DMSO was carried out.
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PMC9429973
Furthermore, healthy patients (n = 8) were included as controls (C).
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PMC10243817
A total of 117 controls, 118 patients with eosinophilic CRSwNP, 113 patients with noneosinophilic CRSwNP, and 103 patients with CRSsNP were enrolled in this study.
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PMC5417661
The plasma levels of NOV202 were determined after PO administration at 1 and 4 h post-dosing.
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PMC11754784
Besides, the concentration-dependent non-specific cell binding was negligible, as demonstrated by flow cytometry (Supplementary Fig. 7).
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PMC11545868
When Fas binds to its Fas ligand (FasL), which is normally expressed on the surface of cytotoxic T cells, it triggers a signal transduction cascade within the cell.
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PMC10761571
The use of nanotechnology products with supermagnetic properties for targeted delivery of drugs has gained attention recently.
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PMC10125312
Effect of AuNR-PEG concentration on cellular viability. (
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PMC11546117
Briefly, PMC42-LA cells were cultured in RPMI-1640, with addition of 10% FBS and 1% penicillin/streptomycin.
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PMC11627060
For instance, the intrinsic pathway typically involves mitochondrial damage, whereas the extrinsic pathway relies on receptor–ligand interactions .
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PMC9583612
The CHIPS and Science Act authorizes the establishment of a Center for Greenhouse Gas (GHG) Measurements, Standards, and Information to improve spatially and temporally resolved GHG measurements.
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PMC9429973
SPSS22.0 and GraphPad Prism 8 were used to analyze the data.
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PMC11765988
A recent meta-analysis reported an overall RR of 3.67 (2.92–4.63) for lymphoma in patients with sarcoidosis .
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PMC11754094
The infected cells were selected with puromycin and transfected with Cas9 RNP complex targeting the puromycin resistance gene using electroporation.
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PMC11119602
Whereas the total mRNA levels of TG2 in HepG2/cr were approximately 50% of those of parental cells, this reflected changes in TG2-L and not in TG2-S protein levels, which stayed approximately constant (Figure 2A,B).
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PMC11643361
complexes with similar ligands (66–69, Figure 7) were also studied for their cytotoxic effects against ovarian cancer (A2780), cisplatin-resistant (A2780R), human osteosarcoma (HOS), and colon carcinoma (CaCo-2) cell lines , compared to the standard chemotherapeutics cisplatin, oxaliplatin, and carboplatin.
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PMC7185206
An asterisk (*) denotes moderate to intense staining as scored by a pathologist. (
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PMC11543853
The tilt series were collected using SerialEM software with a dose-symmetric tilt scheme with an angular range of ±52° (2° increment) or ±60° (3° increment).
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PMC11762280
The statistic of epidermal thickness and average optical density of TUNEL positive staining were analyzed (n = 5).
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PMC11694625
C NMR (101 MHz, DMSO-d6) δ 162.31, 158.11, 150.56, 145.72, 139.41, 137.07, 132.31, 129.49, 128.60, 127.20, 125.35, 122.31, 81.88.
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PMC11705484
Expression of TRMT61A in 5637 cells after vehicle control and/or IκBαS32AS36A treatment. (
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PMC10965315
The apoptosis of harmaline‐treated A2780 cells was analyzed by flow cytometry.
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PMC9780037
Those alterations can uncover molecules whose concentrations, modifications, and/or subcellular locations are altered.
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PMC10728200
The cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h or treated with IM (50 nM for T1 and 200 nM for 882) for 0, 12, 24, or 48 h. The histograms indicate the levels of the protein determined from 3 independent experiments expressed as the mean ratio relative to that in the untreated control after normalization to GAPDH.
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PMC9429973
This entity has a good prognosis and its treatment options are very limited, especially for elderly patients.
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PMC10203589
In addition, the IPA-MAP pathway prediction analysis showed that cordycepin inhibited the proliferation of MA-10 cells by inhibiting the FGFs/FGFRs pathway (167).
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PMC9429973
Finally, the presence of 11 patients carrying germlines JAK2 mutations is surprising, and we suppose it will be necessary to strictly watch these patients in the suspicion of a future appearance of a polycythemia vera.
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PMC11471157
The results revealed that DFP supports the adhesion and proliferation of various cell types, including human epidermal cells, human malignant melanoma cells, mouse fibroblasts, mouse endothelial cells and fish fibroblasts.
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PMC11706776
p < 0.05; **p < 0.01; ***p < 0.001 (boxes indicate the first and third quartiles—and the median inside—of the different measures.
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PMC11762280
F Representative photos of mice receiving DSF or vehicle treatment at 48 h after UVB exposure.
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PMC11736898
We found that vitamin D treatment significantly reduced EDN1 expression in keloid keratinocytes but not normal keratinocytes (Figure 7e).
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PMC11201245
The counting of signal constellations that deviated from the diploid pattern resulted in an average of 15.38%.
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PMC10919056
A total of 21 GJPs were observed to be expressed in ccRCC.
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PMC11240571
In the present study, exosomes derived from sarcoma cells inhibited IFN-γ production.
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PMC11594074
The apoptotic trigger is regulated by several upstream and downstream signaling factors, including the BCL-2 protein family.
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PMC11267830
Deletion of THOC1 slows proliferation, increases apoptosis and disrupts the cell cycle in T-ALL cells, ultimately leading to T-ALL cell death T-ALL is a severe malignancy characterized by a high incidence of complications and a poor prognosis .
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PMC11412721
We analyzed public databases of B-cell lymphomas patients with clinical and gene expression information.
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PMC3164356
The amplification products from each chamber were retrieved separately.
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PMC9822769
Complex 2 showed an anomalous higher cytotoxicity (similar to that of cisplatin) with respect to their analogues 1 and 3.
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PMC10040136
Further investigation is required to elucidate the specific alterations that occur in MSC within the tumor microenvironment, which confer a drug-resistant phenotype.
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PMC10551595
Binding to Cys124 had previously shown a critical role in the restoration of the mutant P53 function. ,
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PMC10940855
Data were analyzed on FACS Diva version 8 and FlowJo version 10 software.
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PMC7961460
Cell lysates were scraped on ice and the protein content was measured using Coomassie Protein Assay kit (Thermo Scientific, Milan, Italy).
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PMC11794847
The immune microenvironment of HVEM KO mice bearing mouse lung cancer cell was also evaluated.
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PMC11759543
The cell viability analysis was conducted to assess the effect of the combination of doxorubicin and vorinostat on cytotoxicity.
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PMC9268183
The aim of this search was mainly to review the existence of cytotoxic activity tests in cancer cell lines involving the plant species of interest.
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