OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11641532	The 3000 most variable features were identified using the “vst” method, and significant principal components were detected using principal component analysis (PCA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "3000", "most", "variable", "features", "were", "identified", "using", "the", "“", "vst", "”", "method", ",", "and", "significant", "principal", "components", "were", "detected", "using", "principal", "component", "analysis", "(", "PCA", ")", "." ] } ]
PMC11792740	Furthermore, interdisciplinary, cross-disciplinary, and international collaborative innovations are necessary for developing more effective and safer treatments for tumor patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "interdisciplinary", ",", "cross-disciplinary", ",", "and", "international", "collaborative", "innovations", "are", "necessary", "for", "developing", "more", "effective", "and", "safer", "treatments", "for", "tumor", "patients", "." ] } ]
PMC11322866	The bottom row contains images enlarged from the boxed area in the corresponding panel in the top row. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bottom", "row", "contains", "images", "enlarged", "from", "the", "boxed", "area", "in", "the", "corresponding", "panel", "in", "the", "top", "row", ".", "", "", "*" ] } ]
PMC11787355	Ethical approval for the isolation of brain tumor tissue and analyses was obtained from the Mannheim Medical Faculty Ethics Committee (2017-589N-MA, 608-22, 574-23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ethical", "approval", "for", "the", "isolation", "of", "brain", "tumor", "tissue", "and", "analyses", "was", "obtained", "from", "the", "Mannheim", "Medical", "Faculty", "Ethics", "Committee", "(", "2017", "-", "589N-MA", ",", "608", "-", "22", ",", "574", "-", "23", ")", "." ] } ]
PMC11607321	Consequently, including omics that are less strongly structured by tissue will naturally result in looser tissue clustering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "including", "omics", "that", "are", "less", "strongly", "structured", "by", "tissue", "will", "naturally", "result", "in", "looser", "tissue", "clustering", "." ] } ]
PMC9429973	Moreover, based on NO we inferred lowest activity of TP53 pathway in the cells with TP53 aberrations, emphasizing the role of TP53 in intra-patient cytogenetic evolution as well as inter-patient heterogeneity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "based", "on", "NO", "we", "inferred", "lowest", "activity", "of", "TP53", "pathway", "in", "the", "cells", "with", "TP53", "aberrations", ",", "emphasizing", "the", "role", "of", "TP53", "in", "intra-patient", "cytogenetic", "evolution", "as", "well", "as", "inter-patient", "heterogeneity", "." ] } ]
PMC9261184	A measurement campaign was carried out over a full roundtrip voyage from loading, the cargo-laden voyage, unloading, and the return ballast voyage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "measurement", "campaign", "was", "carried", "out", "over", "a", "full", "roundtrip", "voyage", "from", "loading", ",", "the", "cargo-laden", "voyage", ",", "unloading", ",", "and", "the", "return", "ballast", "voyage", "." ] } ]
PMC9000591	The remaining samples including SE1, SE3, and SE4 presented insignificant differences, with IC50 values of 179.04, 169.06, and 152.91 µg/mL, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "remaining", "samples", "including", "SE1", ",", "SE3", ",", "and", "SE4", "presented", "insignificant", "differences", ",", "with", "IC50", "values", "of", "179.04", ",", "169.06", ",", "and", "152.91", "µg/mL", ",", "respectively", "." ] } ]
PMC7961460	Hence, we propose that c10orf118 is a novel player in the crosstalk between breast cancer cells and the stromal microenvironment and that its specific secretion may be related to the different aggressiveness of the tumour.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "we", "propose", "that", "c10orf118", "is", "a", "novel", "player", "in", "the", "crosstalk", "between", "breast", "cancer", "cells", "and", "the", "stromal", "microenvironment", "and", "that", "its", "specific", "secretion", "may", "be", "related", "to", "the", "different", "aggressiveness", "of", "the", "tumour", "." ] } ]
PMC11661040	Meanwhile, GSK3β can phosphorylate β-catenin, promoting its rapid degradation and preventing the transcription of β-catenin target genes in the cell nucleus(Zeng et al. 2005; Aberle et al. 1997).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "GSK3β", "can", "phosphorylate", "β-catenin", ",", "promoting", "its", "rapid", "degradation", "and", "preventing", "the", "transcription", "of", "β-catenin", "target", "genes", "in", "the", "cell", "nucleus(Zeng", "et", "al.", "2005", ";", "Aberle", "et", "al.", "1997", ")", "." ] } ]
PMC9275501	When nanoparticles are modified with various ligands, they can specifically target components in the tumor microenvironment, including dendritic cells, macrophages, fibroblasts, tumor vascular system (Yang et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "nanoparticles", "are", "modified", "with", "various", "ligands", ",", "they", "can", "specifically", "target", "components", "in", "the", "tumor", "microenvironment", ",", "including", "dendritic", "cells", ",", "macrophages", ",", "fibroblasts", ",", "tumor", "vascular", "system", "(", "Yang", "et", "al.", ",", "2021", ")", "." ] } ]
PMC9516447	Data are presented as mean ± S.D. * P ≤ 0.05, P ≤ 0.01, * P ≤ 0.001 (Student's t test).Fig 1 Knockdown of GRP78 via siRNA reduces KRAS protein level in human cancer cell lines with various KRAS mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "mean", "±", "S.D.", "", "P", "≤", "0.05", ",", "", "", "P", "≤", "0.01", ",", "", "", "", "P", "≤", "0.001", "(", "Student", "'s", "t", "test).Fig", "1", "Knockdown", "of", "GRP78", "via", "siRNA", "reduces", "KRAS", "protein", "level", "in", "human", "cancer", "cell", "lines", "with", "various", "KRAS", "mutations", "." ] } ]
PMC5963610	The induction of a cellular immune response of 7A7 mAb and NGcGM3/VSSP vaccine has described, for their anti-metastatic effect in the 3LLD122-model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "induction", "of", "a", "cellular", "immune", "response", "of", "7A7", "mAb", "and", "NGcGM3/VSSP", "vaccine", "has", "described", ",", "for", "their", "anti-metastatic", "effect", "in", "the", "3LLD122-model", "." ] } ]
PMC10976516	Pie chart illustrating the overall prevalence of common lung cancer (sub)types About 80% of SCLC patients are ever-smokers vs. only 16% never-smokers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pie", "chart", "illustrating", "the", "overall", "prevalence", "of", "common", "lung", "cancer", "(sub)types", "About", "80", "%", "of", "SCLC", "patients", "are", "ever-smokers", "vs.", "only", "16", "%", "never-smokers", "." ] } ]
PMC10958426	The entropy and inferred CNV score of each tumor subclone are calculated by averaging the entropies and inferred CNV scores of all the cells in the subclone, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "entropy", "and", "inferred", "CNV", "score", "of", "each", "tumor", "subclone", "are", "calculated", "by", "averaging", "the", "entropies", "and", "inferred", "CNV", "scores", "of", "all", "the", "cells", "in", "the", "subclone", ",", "respectively", "." ] } ]
PMC11087055	Embryos were soaked in Tyrode’s solution containing BrdU (final concentration; 0.1 mM, Thermo Fisher, B23151) with or without aphidicolin (SIGMA, A0781) at 37 °C for 15 min, and cultured for 12 hr at 37 °C (BrdU was incorporated for 12 hr).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Embryos", "were", "soaked", "in", "Tyrode", "’s", "solution", "containing", "BrdU", "(", "final", "concentration", ";", "0.1", "mM", ",", "Thermo", "Fisher", ",", "B23151", ")", "with", "or", "without", "aphidicolin", "(", "SIGMA", ",", "A0781", ")", "at", "37", "°", "C", "for", "15", "min", ",", "and", "cultured", "for", "12", "hr", "at", "37", "°", "C", "(", "BrdU", "was", "incorporated", "for", "12", "hr", ")", "." ] } ]
PMC7305184	The use of Pulsed Electric Field (PEF) treatment has increased over the last few decades.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "Pulsed", "Electric", "Field", "(", "PEF", ")", "treatment", "has", "increased", "over", "the", "last", "few", "decades", "." ] } ]
PMC9325715	Finally, it was shown that formation of supersaturated iron-protein structures which include LTF often accompanies development of neurodegenerative diseases such as Alzheimer or Parkinson.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "it", "was", "shown", "that", "formation", "of", "supersaturated", "iron-protein", "structures", "which", "include", "LTF", "often", "accompanies", "development", "of", "neurodegenerative", "diseases", "such", "as", "Alzheimer", "or", "Parkinson", "." ] } ]
PMC10812665	This is only apparently a contradiction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "only", "apparently", "a", "contradiction", "." ] } ]
PMC11791432	GBM cells, immune cells and normal cells were separated on Umap, and the ANXA1 expression was annotated with purple.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GBM", "cells", ",", "immune", "cells", "and", "normal", "cells", "were", "separated", "on", "Umap", ",", "and", "the", "ANXA1", "expression", "was", "annotated", "with", "purple", "." ] } ]
PMC11025866	Candidates for repressors of EBV reactivation were identified as the expressed genes that overlapped between cells that were inhibited in EBV reactivation (i.e VPA and VPM-treated) and cellular transcripts that were excluded from reactivated cells (butyrate-treated).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Candidates", "for", "repressors", "of", "EBV", "reactivation", "were", "identified", "as", "the", "expressed", "genes", "that", "overlapped", "between", "cells", "that", "were", "inhibited", "in", "EBV", "reactivation", "(", "i.e", "VPA", "and", "VPM-treated", ")", "and", "cellular", "transcripts", "that", "were", "excluded", "from", "reactivated", "cells", "(", "butyrate-treated", ")", "." ] } ]
PMC11585994	Representative TEM images of G5 (left) and G5-sgc8-siBCL11B (right) nanoparticles. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "TEM", "images", "of", "G5", "(", "left", ")", "and", "G5-sgc8-siBCL11B", "(", "right", ")", "nanoparticles", ".", "(" ] } ]
PMC10936243	This could be done by asking the client to bring bedding or clothes for their pet which would help to maintain the familiar smell and scents of home for the cats (Ellis et al. 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "could", "be", "done", "by", "asking", "the", "client", "to", "bring", "bedding", "or", "clothes", "for", "their", "pet", "which", "would", "help", "to", "maintain", "the", "familiar", "smell", "and", "scents", "of", "home", "for", "the", "cats", "(", "Ellis", "et", "al.", "2013", ")", "." ] } ]
PMC11576293	This experiment examines the impact of the newly developed compounds 9–29 on normal cell lines to assess their safety level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "experiment", "examines", "the", "impact", "of", "the", "newly", "developed", "compounds", "9–29", "on", "normal", "cell", "lines", "to", "assess", "their", "safety", "level", "." ] } ]
PMC10940855	Investigators were not blinded and no animals were excluded from the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Investigators", "were", "not", "blinded", "and", "no", "animals", "were", "excluded", "from", "the", "analysis", "." ] } ]
PMC9341513	Yellow blocks indicate regions with chromatin states associated with H3K27ac and indicate regions which have a more open chromatin structure in the model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yellow", "blocks", "indicate", "regions", "with", "chromatin", "states", "associated", "with", "H3K27ac", "and", "indicate", "regions", "which", "have", "a", "more", "open", "chromatin", "structure", "in", "the", "model", "." ] } ]
PMC11490153	Citral, a monoterpene aldehyde and major compound in C. citratus EO, possesses various biological effects, including anticancer, antioxidant, and antibacterial activities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Citral", ",", "a", "monoterpene", "aldehyde", "and", "major", "compound", "in", "C.", "citratus", "EO", ",", "possesses", "various", "biological", "effects", ",", "including", "anticancer", ",", "antioxidant", ",", "and", "antibacterial", "activities", "." ] } ]
PMC11714165	Primary bone marrow cells were harvested from C57 mice (8‐week‐old) by flushing the cavities of the tibia and femur.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "bone", "marrow", "cells", "were", "harvested", "from", "C57", "mice", "(", "8‐week‐old", ")", "by", "flushing", "the", "cavities", "of", "the", "tibia", "and", "femur", "." ] } ]
PMC8592717	In experimentally developed chronic intermittent hypoxia rat models, PCA reversed the neurocognitive function impairment through modulation of synaptic plasticity, inhibition of ROS production, and neuronal apoptosis, as well as induction of glial cell proliferation and brain-derived neurotrophic factor (BDNF) expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "experimentally", "developed", "chronic", "intermittent", "hypoxia", "rat", "models", ",", "PCA", "reversed", "the", "neurocognitive", "function", "impairment", "through", "modulation", "of", "synaptic", "plasticity", ",", "inhibition", "of", "ROS", "production", ",", "and", "neuronal", "apoptosis", ",", "as", "well", "as", "induction", "of", "glial", "cell", "proliferation", "and", "brain-derived", "neurotrophic", "factor", "(", "BDNF", ")", "expression", "." ] } ]
PMC11594588	Strong platelet activation characterized by a drastic increase in mitochondrial and cytosolic calcium also appears to initiate the collapse of the mitochondrial membrane potential (ΔΨ m) via a cyclophilin D (CypD)-dependent mechanism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strong", "platelet", "activation", "characterized", "by", "a", "drastic", "increase", "in", "mitochondrial", "and", "cytosolic", "calcium", "also", "appears", "to", "initiate", "the", "collapse", "of", "the", "mitochondrial", "membrane", "potential", "(", "ΔΨ", "m", ")", "via", "a", "cyclophilin", "D", "(CypD)-dependent", "mechanism", "." ] } ]
PMC9268620	The melting point of nordamnacanthal was 214–218 °C, and damnacanthal was 208–211 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "melting", "point", "of", "nordamnacanthal", "was", "214–218", "°", "C", ",", "and", "damnacanthal", "was", "208–211", "°", "C", "." ] } ]
PMC9583612	Bridger measured this high tank emission coming from four emission locations on three closely located tanks on site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bridger", "measured", "this", "high", "tank", "emission", "coming", "from", "four", "emission", "locations", "on", "three", "closely", "located", "tanks", "on", "site", "." ] } ]
PMC11599565	Nested cells represent a unique cellular subpopulation capable of binary differentiation: on one hand, they maintain the condition of cancer stem cell in a small fraction (probably via multinucleation) as seen by the expression of stem cell markers like Oct-4, SOX2 and Klf-4 and, on the other hand, they differentiate towards an epithelial condition as seen by gradual loss of mesenchymal characteristics in parallel with the acquisition of the epithelial phenotype, thus shaping the cellular heterogeneity present in tumors (Fig. 5, Panel D, SF10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nested", "cells", "represent", "a", "unique", "cellular", "subpopulation", "capable", "of", "binary", "differentiation", ":", "on", "one", "hand", ",", "they", "maintain", "the", "condition", "of", "cancer", "stem", "cell", "in", "a", "small", "fraction", "(", "probably", "via", "multinucleation", ")", "as", "seen", "by", "the", "expression", "of", "stem", "cell", "markers", "like", "Oct-4", ",", "SOX2", "and", "Klf-4", "and", ",", "on", "the", "other", "hand", ",", "they", "differentiate", "towards", "an", "epithelial", "condition", "as", "seen", "by", "gradual", "loss", "of", "mesenchymal", "characteristics", "in", "parallel", "with", "the", "acquisition", "of", "the", "epithelial", "phenotype", ",", "thus", "shaping", "the", "cellular", "heterogeneity", "present", "in", "tumors", "(", "Fig.", "5", ",", "Panel", "D", ",", "SF10", ")", "." ] } ]
PMC11518702	Expression of HGAL (GFP-fusion), and of HGAL-GFP-Y107F, also differentially affected BCR-induced SMAC formation (8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "HGAL", "(", "GFP-fusion", ")", ",", "and", "of", "HGAL-GFP-Y107F", ",", "also", "differentially", "affected", "BCR-induced", "SMAC", "formation", "(", "8)", "." ] } ]
PMC11765988	Key proteins involved in these changes include PSMA7, PSMB6, PSMA5, PSMA6, PSMB4, PSMA3, PSMB5, PSMA4, PSMB2, and PSMA2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "proteins", "involved", "in", "these", "changes", "include", "PSMA7", ",", "PSMB6", ",", "PSMA5", ",", "PSMA6", ",", "PSMB4", ",", "PSMA3", ",", "PSMB5", ",", "PSMA4", ",", "PSMB2", ",", "and", "PSMA2", "." ] } ]
PMC9429973	A prior CLL, diagnosed in 2014-2019, was identified through cross-linkage with the NCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "prior", "CLL", ",", "diagnosed", "in", "2014", "-", "2019", ",", "was", "identified", "through", "cross-linkage", "with", "the", "NCR", "." ] } ]
PMC5363531	These preliminary observations prompted further investigations on the PI3K-Akt-mTOR pathway, with the hypothesis that SRC and TS modulation could converge in this signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "preliminary", "observations", "prompted", "further", "investigations", "on", "the", "PI3K-Akt-mTOR", "pathway", ",", "with", "the", "hypothesis", "that", "SRC", "and", "TS", "modulation", "could", "converge", "in", "this", "signaling", "pathway", "." ] } ]
PMC9429973	Aims: The aims of this study are (i) to evaluate the capacity of a real-world program to provide high-quality data that translate into meaningful clinical endpoints, and (ii) to describe the demographic and clinical characteristics as well as therapeutic management and treatment effectiveness of 1 line (1L) DLBCL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "aims", "of", "this", "study", "are", "(", "i", ")", "to", "evaluate", "the", "capacity", "of", "a", "real-world", "program", "to", "provide", "high-quality", "data", "that", "translate", "into", "meaningful", "clinical", "endpoints", ",", "and", "(", "ii", ")", "to", "describe", "the", "demographic", "and", "clinical", "characteristics", "as", "well", "as", "therapeutic", "management", "and", "treatment", "effectiveness", "of", "1", "line", "(", "1L", ")", "DLBCL", "patients", "." ] } ]
PMC10669966	Higher PDE3A expression in MLPS was also seen in mRNA levels (Figure S1A), and a positive correlation between mRNA and protein expression was observed (Spearman’s ρ = 0.423, p < 0.001) (Figure S1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Higher", "PDE3A", "expression", "in", "MLPS", "was", "also", "seen", "in", "mRNA", "levels", "(", "Figure", "S1A", ")", ",", "and", "a", "positive", "correlation", "between", "mRNA", "and", "protein", "expression", "was", "observed", "(", "Spearman", "’s", "ρ", "=", "0.423", ",", "p", "<", "0.001", ")", "(", "Figure", "S1B", ")", "." ] } ]
PMC11659921	To enhance the verification of the possible roles of genes related to angiogenesis and stemness, functional enrichment analysis was performed on the data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "enhance", "the", "verification", "of", "the", "possible", "roles", "of", "genes", "related", "to", "angiogenesis", "and", "stemness", ",", "functional", "enrichment", "analysis", "was", "performed", "on", "the", "data", "." ] } ]
PMC10854447	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC11725127	GFP-KRAS was overexpressed in USP2 knockout RPMI 8226 cells and the indicated proteins were examined by Western blot. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GFP-KRAS", "was", "overexpressed", "in", "USP2", "knockout", "RPMI", "8226", "cells", "and", "the", "indicated", "proteins", "were", "examined", "by", "Western", "blot", ".", "(" ] } ]
PMC11592837	The study was conducted in accordance with the Declaration of Helsinki, and local ethics committee approval was obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "was", "conducted", "in", "accordance", "with", "the", "Declaration", "of", "Helsinki", ",", "and", "local", "ethics", "committee", "approval", "was", "obtained", "." ] } ]
PMC11548041	MNVs as well as other biologically derived nanovesicles can be loaded with exogenous cargo, such as non-coding RNAs, and deliver this bioactive cargo to recipient cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MNVs", "as", "well", "as", "other", "biologically", "derived", "nanovesicles", "can", "be", "loaded", "with", "exogenous", "cargo", ",", "such", "as", "non-coding", "RNAs", ",", "and", "deliver", "this", "bioactive", "cargo", "to", "recipient", "cells", "." ] } ]
PMC11078693	Slowly add 1 mL of PBS to the edge of the glass; strong flow can detach cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slowly", "add", "1", "mL", "of", "PBS", "to", "the", "edge", "of", "the", "glass", ";", "strong", "flow", "can", "detach", "cells", "." ] } ]
PMC11796104	Whole blood was collected from patients using the same method as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole", "blood", "was", "collected", "from", "patients", "using", "the", "same", "method", "as", "previously", "described", "." ] } ]
PMC11422150	As far as our investigation extends, a three-dimensional treadmill gait analysis system is the most sophisticated method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "far", "as", "our", "investigation", "extends", ",", "a", "three-dimensional", "treadmill", "gait", "analysis", "system", "is", "the", "most", "sophisticated", "method", "." ] } ]
PMC11621493	Statistical comparison in all graphs was performed with an unpaired two-tailed Student’s t test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "comparison", "in", "all", "graphs", "was", "performed", "with", "an", "unpaired", "two-tailed", "Student", "’s", "t", "test", "." ] } ]
PMC11672142	The UV–vis spectra for the two in situ prepared solutions collected at 50 μM Fe(III) exhibit two distinct species (Figure S14) and were corrected for excess ligand in the respective solutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "UV", "–", "vis", "spectra", "for", "the", "two", "in", "situ", "prepared", "solutions", "collected", "at", "50", "μM", "Fe(III", ")", "exhibit", "two", "distinct", "species", "(", "Figure", "S14", ")", "and", "were", "corrected", "for", "excess", "ligand", "in", "the", "respective", "solutions", "." ] } ]
PMC11727907	The anaerobic glycolysis yield was determined by calculating the percentage of real lactate released by ARPE-19 cells in the growth medium relative to the theoretical lactate production, calculated as twice the amount of glucose consumed (since, in exclusive anaerobic metabolism, one glucose molecule is converted into two lactate molecules) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anaerobic", "glycolysis", "yield", "was", "determined", "by", "calculating", "the", "percentage", "of", "real", "lactate", "released", "by", "ARPE-19", "cells", "in", "the", "growth", "medium", "relative", "to", "the", "theoretical", "lactate", "production", ",", "calculated", "as", "twice", "the", "amount", "of", "glucose", "consumed", "(", "since", ",", "in", "exclusive", "anaerobic", "metabolism", ",", "one", "glucose", "molecule", "is", "converted", "into", "two", "lactate", "molecules", ")", "." ] } ]
PMC11707577	Spheroid disaggregation was evaluated by the acquisition of images with NIKON A1R confocal microscope as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spheroid", "disaggregation", "was", "evaluated", "by", "the", "acquisition", "of", "images", "with", "NIKON", "A1R", "confocal", "microscope", "as", "previously", "described", "." ] } ]
PMC9429973	After combination therapy, pts may continue with SA siremadlin maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "combination", "therapy", ",", "pts", "may", "continue", "with", "SA", "siremadlin", "maintenance", "." ] } ]
PMC3681794	HOS cells have an aberrantly activated PI3K pathway with strong expression of PTEN, Akt and pS473 Akt in both normoxia and hypoxia (data not shown).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HOS", "cells", "have", "an", "aberrantly", "activated", "PI3", "K", "pathway", "with", "strong", "expression", "of", "PTEN", ",", "Akt", "and", "pS473", "Akt", "in", "both", "normoxia", "and", "hypoxia", "(", "data", "not", "shown", ")", "." ] } ]
PMC9429973	At the end of the 4 courses, the pre-auto-SCT response was: CR 29 (27%), Partial Response (PR) 9 (17%); according to arm of randomization, the primary end point was not met, with CR 28% for R-DHAP and 26% for BR-DHAP (p-value 0.563).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "end", "of", "the", "4", "courses", ",", "the", "pre-auto-SCT", "response", "was", ":", "CR", "29", "(", "27", "%", ")", ",", "Partial", "Response", "(", "PR", ")", "9", "(", "17", "%", ")", ";", "according", "to", "arm", "of", "randomization", ",", "the", "primary", "end", "point", "was", "not", "met", ",", "with", "CR", "28", "%", "for", "R-DHAP", "and", "26", "%", "for", "BR-DHAP", "(", "p-value", "0.563", ")", "." ] } ]
PMC11499955	The limits of detection and quantification in solution of each TMPP-tag were then determined by LC-MS/MS analysis and found to be ∼20 pM and ∼70 pM respectively in DMEM cell media, whatever is the tag isotopologue (Table S3†).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "limits", "of", "detection", "and", "quantification", "in", "solution", "of", "each", "TMPP-tag", "were", "then", "determined", "by", "LC-MS/MS", "analysis", "and", "found", "to", "be", "∼20", "pM", "and", "∼70", "pM", "respectively", "in", "DMEM", "cell", "media", ",", "whatever", "is", "the", "tag", "isotopologue", "(", "Table", "S3†", ")", "." ] } ]
PMC11670407	Subsequently, the samples were rinsed with propylene oxide and impregnated with epoxy resin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "samples", "were", "rinsed", "with", "propylene", "oxide", "and", "impregnated", "with", "epoxy", "resin", "." ] } ]
PMC11457557	This method has the potential to provide more locations for DVC genomic study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "method", "has", "the", "potential", "to", "provide", "more", "locations", "for", "DVC", "genomic", "study", "." ] } ]
PMC9429973	We performed an international randomized phase III study to investigate the efficacy of rituximab when added to methotrexate, BCNU, teniposide and prednisolone (MBVP) in PCNSL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "performed", "an", "international", "randomized", "phase", "III", "study", "to", "investigate", "the", "efficacy", "of", "rituximab", "when", "added", "to", "methotrexate", ",", "BCNU", ",", "teniposide", "and", "prednisolone", "(", "MBVP", ")", "in", "PCNSL", "." ] } ]
PMC11536589	Increased expression of MGST1 weakened the cytotoxicity of MRTX1133 by inhibiting lipid peroxidation-induced ferroptosis in KRAS inhibitor-resistant PDAC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "expression", "of", "MGST1", "weakened", "the", "cytotoxicity", "of", "MRTX1133", "by", "inhibiting", "lipid", "peroxidation-induced", "ferroptosis", "in", "KRAS", "inhibitor-resistant", "PDAC", "cells", "." ] } ]
PMC11687663	The energy minimum for both compounds is expected to be located at the point of contact with the initial lipid layer (about 2 nm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "energy", "minimum", "for", "both", "compounds", "is", "expected", "to", "be", "located", "at", "the", "point", "of", "contact", "with", "the", "initial", "lipid", "layer", "(", "about", "2", "nm", ")", "." ] } ]
PMC10808409	Model analysis showed that the total Pluronic mixture (X1) and Pluronic P123% (X2) had significant effects on EE% and PS, while drug amount (X3) had a significant effect only on the EE%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Model", "analysis", "showed", "that", "the", "total", "Pluronic", "mixture", "(", "X1", ")", "and", "Pluronic", "P123", "%", "(", "X2", ")", "had", "significant", "effects", "on", "EE%", "and", "PS", ",", "while", "drug", "amount", "(", "X3", ")", "had", "a", "significant", "effect", "only", "on", "the", "EE%", "." ] } ]
PMC11562028	When cells undergo oxidative damage, it often leads to abnormal mitochondrial function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "cells", "undergo", "oxidative", "damage", ",", "it", "often", "leads", "to", "abnormal", "mitochondrial", "function", "." ] } ]
PMC11496728	The results of early optimization indicated that compared with the control vector expressing eGFP, the vector with the Kozak sequence, as well as the combined sequence of Kozak and Leader, was increased by 1.26- and 2.2-fold, respectively, and the fluorescence of pCMV-eGFP, pCMV-eGFP-1, and pCMV-eGFP-2 transfected with CHO-KO was remarkably enhanced compared with CHO-WT when expressing eGFP using the novel CHO cell expression system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "early", "optimization", "indicated", "that", "compared", "with", "the", "control", "vector", "expressing", "eGFP", ",", "the", "vector", "with", "the", "Kozak", "sequence", ",", "as", "well", "as", "the", "combined", "sequence", "of", "Kozak", "and", "Leader", ",", "was", "increased", "by", "1.26-", "and", "2.2-fold", ",", "respectively", ",", "and", "the", "fluorescence", "of", "pCMV-eGFP", ",", "pCMV-eGFP-1", ",", "and", "pCMV-eGFP-2", "transfected", "with", "CHO-KO", "was", "remarkably", "enhanced", "compared", "with", "CHO-WT", "when", "expressing", "eGFP", "using", "the", "novel", "CHO", "cell", "expression", "system", "." ] } ]
PMC7917457	For the MAGE-A3 assay, CD8 T cells were presensitized with tumor antigen-containing peptide MAGE-A3(168−176).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "MAGE-A3", "assay", ",", "CD8", "T", "cells", "were", "presensitized", "with", "tumor", "antigen-containing", "peptide", "MAGE-A3(168−176", ")", "." ] } ]
PMC11746942	Using genetic and pharmacological approaches, we reveal a novel S1PR3–Src–STAT3 signaling axis that drives both early and prolonged STAT3 activation in keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "genetic", "and", "pharmacological", "approaches", ",", "we", "reveal", "a", "novel", "S1PR3–Src", "–", "STAT3", "signaling", "axis", "that", "drives", "both", "early", "and", "prolonged", "STAT3", "activation", "in", "keratinocytes", "." ] } ]
PMC11637820	These foot ulcers occur when a particular area of the foot has been subjected to continuous pressure or trauma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "foot", "ulcers", "occur", "when", "a", "particular", "area", "of", "the", "foot", "has", "been", "subjected", "to", "continuous", "pressure", "or", "trauma", "." ] } ]
PMC10743717	Whether such an inhibitor could effectively prevent mitochondrial dysfunction is considered an essential criteria for further investigation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whether", "such", "an", "inhibitor", "could", "effectively", "prevent", "mitochondrial", "dysfunction", "is", "considered", "an", "essential", "criteria", "for", "further", "investigation", "." ] } ]
PMC11322866	Taken together, these data show that RRM2 overexpression inhibits EZH2 methyltransferase activity and induces senescence in MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "these", "data", "show", "that", "RRM2", "overexpression", "inhibits", "EZH2", "methyltransferase", "activity", "and", "induces", "senescence", "in", "MM", "cells", "." ] } ]
PMC11672142	That the cell death capability of DefNEtTrp depends on its Fe-binding ability is further supported by the observation that cells presupplemented with Fe display higher resistance toward the cytotoxicity of the dual chelator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "That", "the", "cell", "death", "capability", "of", "DefNEtTrp", "depends", "on", "its", "Fe-binding", "ability", "is", "further", "supported", "by", "the", "observation", "that", "cells", "presupplemented", "with", "Fe", "display", "higher", "resistance", "toward", "the", "cytotoxicity", "of", "the", "dual", "chelator", "." ] } ]
PMC11499381	These constructs are referred to as wild type (WT) throughout the manuscript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "constructs", "are", "referred", "to", "as", "wild", "type", "(", "WT", ")", "throughout", "the", "manuscript", "." ] } ]
PMC11732635	The ileum and colon biopsy revealed EBV-positive lymphoproliferative disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ileum", "and", "colon", "biopsy", "revealed", "EBV-positive", "lymphoproliferative", "disease", "." ] } ]
PMC10812665	It is possible that low test compound concentrations (≤BMC25NA) triggered a transient response between 4 and 16 h. Mitochondrial dysfunction, primary or secondary, is a common feature of neurodegeneration and neurotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "possible", "that", "low", "test", "compound", "concentrations", "(", "≤BMC25NA", ")", "triggered", "a", "transient", "response", "between", "4", "and", "16", "h.", "Mitochondrial", "dysfunction", ",", "primary", "or", "secondary", ",", "is", "a", "common", "feature", "of", "neurodegeneration", "and", "neurotoxicity", "." ] } ]
PMC11621565	, Phorbol 12-Myristate 13-Acetate (PMA) (cat.no.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ",", "Phorbol", "12-Myristate", "13-Acetate", "(", "PMA", ")", "(", "cat.no", "." ] } ]
PMC9454178	Annexin V/PI staining illustrated that the percentage of apoptotic cells significantly increased in a THZ1 dose-dependent manner (Fig. 3D, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annexin", "V/PI", "staining", "illustrated", "that", "the", "percentage", "of", "apoptotic", "cells", "significantly", "increased", "in", "a", "THZ1", "dose-dependent", "manner", "(", "Fig.", "3D", ",", "E", ")", "." ] } ]
PMC9712534	The neurological defects in TOP2B knockout mice are currently ascribed to the perturbation of TOP2B-mediated gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "neurological", "defects", "in", "TOP2B", "knockout", "mice", "are", "currently", "ascribed", "to", "the", "perturbation", "of", "TOP2B-mediated", "gene", "expression", "." ] } ]
PMC9220170	Similar results were shown by Tanguy Y. et al. on endocrine cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "shown", "by", "Tanguy", "Y.", "et", "al.", "on", "endocrine", "cells", "." ] } ]
PMC9164404	Calcein AM/PI (acetyl methoxy methyl ester/propidium iodide) cell viability kit, DNA extraction kit and Annexin V-FITC apoptosis detection kit was purchased from Beyotime Institute of Biotechnology (Jiangsu, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calcein", "AM/PI", "(", "acetyl", "methoxy", "methyl", "ester/propidium", "iodide", ")", "cell", "viability", "kit", ",", "DNA", "extraction", "kit", "and", "Annexin", "V-FITC", "apoptosis", "detection", "kit", "was", "purchased", "from", "Beyotime", "Institute", "of", "Biotechnology", "(", "Jiangsu", ",", "China", ")", "." ] } ]
PMC11144200	2SO4-HEPES buffer was added for shock, then the liposome solution was ultrasound to transparency by ultrasonic crushing apparatus, and finally transferred to a dialysis bag with 10 kDa molecular weight interception for dialysis to prepare liposomes with ammonium sulfate gradient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2SO4-HEPES", "buffer", "was", "added", "for", "shock", ",", "then", "the", "liposome", "solution", "was", "ultrasound", "to", "transparency", "by", "ultrasonic", "crushing", "apparatus", ",", "and", "finally", "transferred", "to", "a", "dialysis", "bag", "with", "10", "kDa", "molecular", "weight", "interception", "for", "dialysis", "to", "prepare", "liposomes", "with", "ammonium", "sulfate", "gradient", "." ] } ]
PMC9429973	Aims: The primary aim was to assess the pattern of distribution of M-GVs, their correlations with SMF subtype and with driver mutations, in a large cohort of SMF patients studied by next generation sequencing (NGS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "primary", "aim", "was", "to", "assess", "the", "pattern", "of", "distribution", "of", "M-GVs", ",", "their", "correlations", "with", "SMF", "subtype", "and", "with", "driver", "mutations", ",", "in", "a", "large", "cohort", "of", "SMF", "patients", "studied", "by", "next", "generation", "sequencing", "(", "NGS", ")", "." ] } ]
PMC4443654	Acc.,	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Acc", ".", "," ] } ]
PMC11419566	Traditional Chinese medicine (TCM) has been practiced for thousands of years and is now widely recognized as a viable alternative cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Traditional", "Chinese", "medicine", "(", "TCM", ")", "has", "been", "practiced", "for", "thousands", "of", "years", "and", "is", "now", "widely", "recognized", "as", "a", "viable", "alternative", "cancer", "treatment", "." ] } ]
PMC11487720	UV/cold shock-treated L929S cells exhibited relocation of α-tubulin to the nuclear bubble (Fig. 5D, right panel; red arrows; also see an enlarged insert).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UV/cold", "shock-treated", "L929S", "cells", "exhibited", "relocation", "of", "α-tubulin", "to", "the", "nuclear", "bubble", "(", "Fig.", "5D", ",", "right", "panel", ";", "red", "arrows", ";", "also", "see", "an", "enlarged", "insert", ")", "." ] } ]
PMC2193049	Finally, treatment of HLA-A*0201 melanoma cells expressing MAGE-3 with lactacystin or another proteasome inhibitor, N-acetyl-Leu-Leu-norleucinal (LLnL), restored the presentation of MAGE-3271–279.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "treatment", "of", "HLA-A*0201", "melanoma", "cells", "expressing", "MAGE-3", "with", "lactacystin", "or", "another", "proteasome", "inhibitor", ",", "N-acetyl-Leu-Leu-norleucinal", "(", "LLnL", ")", ",", "restored", "the", "presentation", "of", "MAGE-3271–279", "." ] } ]
PMC9844987	However, when analyzing specifically multi-modal low variable promoters (containing at least two decomposed promoters), a strong +1 nucleosome was only observed for promoters with highly correlated decomposed promoters (Figure 4—figure supplement 2C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "when", "analyzing", "specifically", "multi-modal", "low", "variable", "promoters", "(", "containing", "at", "least", "two", "decomposed", "promoters", ")", ",", "a", "strong", "+", "1", "nucleosome", "was", "only", "observed", "for", "promoters", "with", "highly", "correlated", "decomposed", "promoters", "(", "Figure", "4—figure", "supplement", "2C", "and", "D", ")", "." ] } ]
PMC11733919	Furthermore, to potentiate anti-CD26 antibody-mediated cytotoxicity, two HSP90 inhibitors 17-AAG (tanespimycin) and 17-DMAG (alvespimycin) with senolytic activity were loaded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "to", "potentiate", "anti-CD26", "antibody-mediated", "cytotoxicity", ",", "two", "HSP90", "inhibitors", "17-AAG", "(", "tanespimycin", ")", "and", "17-DMAG", "(", "alvespimycin", ")", "with", "senolytic", "activity", "were", "loaded", "." ] } ]
PMC9503669	Thus, 2C may prevent Nef-mediated Src-family kinase activation through allosteric inhibition of kinase recruitment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "2C", "may", "prevent", "Nef-mediated", "Src-family", "kinase", "activation", "through", "allosteric", "inhibition", "of", "kinase", "recruitment", "." ] } ]
PMC8348645	To this, 0.2 mL of concentrated sulphuric acid was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "this", ",", "0.2", "mL", "of", "concentrated", "sulphuric", "acid", "was", "added", "." ] } ]
PMC11659921	The classic OV biomarkers, carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4), can facilitate preliminary diagnosis; however, it is essential to acknowledge issues such as false positives and their limited prognostic predictive capability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "classic", "OV", "biomarkers", ",", "carbohydrate", "antigen", "125", "(", "CA125", ")", "and", "human", "epididymis", "protein", "4", "(", "HE4", ")", ",", "can", "facilitate", "preliminary", "diagnosis", ";", "however", ",", "it", "is", "essential", "to", "acknowledge", "issues", "such", "as", "false", "positives", "and", "their", "limited", "prognostic", "predictive", "capability", "." ] } ]
PMC9429973	Cell viability and cellular growth was evaluated by viable counts and by Cell Titer Glo assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "and", "cellular", "growth", "was", "evaluated", "by", "viable", "counts", "and", "by", "Cell", "Titer", "Glo", "assay", "." ] } ]
PMC9429973	Clinical trial information: NCT05079230.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "trial", "information", ":", "NCT05079230", "." ] } ]
PMC10994876	The cells were seeded on 96-well plates (7 × 10^3 cells/well) and transfected with overexpressing YAP5SA and control plasmids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "seeded", "on", "96-well", "plates", "(", "7", "×", "10", "^", "3", "cells/well", ")", "and", "transfected", "with", "overexpressing", "YAP5SA", "and", "control", "plasmids", "." ] } ]
PMC10854447	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC11672142	This solution is light amber in color.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "solution", "is", "light", "amber", "in", "color", "." ] } ]
PMC11711345	Data was acquired (10 gated events) with a FACScalibur flow cytometer and analyzed using CellQuestTM software (Becton Dickinson, Bioscience, San Jose, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "was", "acquired", "(", "10", "gated", "events", ")", "with", "a", "FACScalibur", "flow", "cytometer", "and", "analyzed", "using", "CellQuestTM", "software", "(", "Becton", "Dickinson", ",", "Bioscience", ",", "San", "Jose", ",", "USA", ")", "." ] } ]
PMC11476106	The media were changed every 2–3 days, and cultures were trypsinized when confluence was reached.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "media", "were", "changed", "every", "2–3", "days", ",", "and", "cultures", "were", "trypsinized", "when", "confluence", "was", "reached", "." ] } ]
PMC11769516	It is important to note that the permeability of mycotoxins, which, as single compounds, cannot penetrate the BBB, may be influenced by the supporting action of other substances including trichothecenes, which include DON and, by impairing the continuity of the barrier, enable them to reach the brain .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "important", "to", "note", "that", "the", "permeability", "of", "mycotoxins", ",", "which", ",", "as", "single", "compounds", ",", "can", "not", "penetrate", "the", "BBB", ",", "may", "be", "influenced", "by", "the", "supporting", "action", "of", "other", "substances", "including", "trichothecenes", ",", "which", "include", "DON", "and", ",", "by", "impairing", "the", "continuity", "of", "the", "barrier", ",", "enable", "them", "to", "reach", "the", "brain", "." ] } ]
PMC9429973	By applying this msPCR on a cohort of 613 CLL patients, our results corroborate the relevance of IGLV3-21 testing to improve the risk stratification of CLL patients in the clinical practice, especially within M-CLL and i-CLL subtypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "applying", "this", "msPCR", "on", "a", "cohort", "of", "613", "CLL", "patients", ",", "our", "results", "corroborate", "the", "relevance", "of", "IGLV3", "-", "21", "testing", "to", "improve", "the", "risk", "stratification", "of", "CLL", "patients", "in", "the", "clinical", "practice", ",", "especially", "within", "M-CLL", "and", "i-CLL", "subtypes", "." ] } ]
PMC11604768	Indeed, heterotypic TRE combinations with elevated transcriptional activity relative to homotypic promoters have been reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "heterotypic", "TRE", "combinations", "with", "elevated", "transcriptional", "activity", "relative", "to", "homotypic", "promoters", "have", "been", "reported", "." ] } ]
PMC11244823	Horse sera differenciated by vaccination status (vac = vaccinated; n-vac = not vaccinted). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Horse", "sera", "differenciated", "by", "vaccination", "status", "(", "vac", "=", "vaccinated", ";", "n-vac", "=", "not", "vaccinted", ")", ".", "(" ] } ]
PMC11806106	This allows the recruitment of arrestins to the receptor, inducing internalization, degradation, or recycling of the receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "allows", "the", "recruitment", "of", "arrestins", "to", "the", "receptor", ",", "inducing", "internalization", ",", "degradation", ",", "or", "recycling", "of", "the", "receptors", "." ] } ]

PMC11641532

The 3000 most variable features were identified using the “vst” method, and significant principal components were detected using principal component analysis (PCA).

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PMC11792740

Furthermore, interdisciplinary, cross-disciplinary, and international collaborative innovations are necessary for developing more effective and safer treatments for tumor patients.

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PMC11322866

The bottom row contains images enlarged from the boxed area in the corresponding panel in the top row. ***

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bottom", "row", "contains", "images", "enlarged", "from", "the", "boxed", "area", "in", "the", "corresponding", "panel", "in", "the", "top", "row", ".", "*", "*", "*" ] } ]

PMC11787355

Ethical approval for the isolation of brain tumor tissue and analyses was obtained from the Mannheim Medical Faculty Ethics Committee (2017-589N-MA, 608-22, 574-23).

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PMC11607321

Consequently, including omics that are less strongly structured by tissue will naturally result in looser tissue clustering.

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PMC9429973

Moreover, based on NO we inferred lowest activity of TP53 pathway in the cells with TP53 aberrations, emphasizing the role of TP53 in intra-patient cytogenetic evolution as well as inter-patient heterogeneity.

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PMC9261184

A measurement campaign was carried out over a full roundtrip voyage from loading, the cargo-laden voyage, unloading, and the return ballast voyage.

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PMC9000591

The remaining samples including SE1, SE3, and SE4 presented insignificant differences, with IC50 values of 179.04, 169.06, and 152.91 µg/mL, respectively.

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PMC7961460

Hence, we propose that c10orf118 is a novel player in the crosstalk between breast cancer cells and the stromal microenvironment and that its specific secretion may be related to the different aggressiveness of the tumour.

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PMC11661040

Meanwhile, GSK3β can phosphorylate β-catenin, promoting its rapid degradation and preventing the transcription of β-catenin target genes in the cell nucleus(Zeng et al. 2005; Aberle et al. 1997).

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PMC9275501

When nanoparticles are modified with various ligands, they can specifically target components in the tumor microenvironment, including dendritic cells, macrophages, fibroblasts, tumor vascular system (Yang et al., 2021).

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PMC9516447

Data are presented as mean ± S.D. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 (Student's t test).Fig 1 Knockdown of GRP78 via siRNA reduces KRAS protein level in human cancer cell lines with various KRAS mutations.

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PMC5963610

The induction of a cellular immune response of 7A7 mAb and NGcGM3/VSSP vaccine has described, for their anti-metastatic effect in the 3LLD122-model.

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PMC10976516

Pie chart illustrating the overall prevalence of common lung cancer (sub)types About 80% of SCLC patients are ever-smokers vs. only 16% never-smokers.

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PMC10958426

The entropy and inferred CNV score of each tumor subclone are calculated by averaging the entropies and inferred CNV scores of all the cells in the subclone, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "entropy", "and", "inferred", "CNV", "score", "of", "each", "tumor", "subclone", "are", "calculated", "by", "averaging", "the", "entropies", "and", "inferred", "CNV", "scores", "of", "all", "the", "cells", "in", "the", "subclone", ",", "respectively", "." ] } ]

PMC11087055

Embryos were soaked in Tyrode’s solution containing BrdU (final concentration; 0.1 mM, Thermo Fisher, B23151) with or without aphidicolin (SIGMA, A0781) at 37 °C for 15 min, and cultured for 12 hr at 37 °C (BrdU was incorporated for 12 hr).

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PMC7305184

The use of Pulsed Electric Field (PEF) treatment has increased over the last few decades.

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PMC9325715

Finally, it was shown that formation of supersaturated iron-protein structures which include LTF often accompanies development of neurodegenerative diseases such as Alzheimer or Parkinson.

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PMC10812665

This is only apparently a contradiction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "only", "apparently", "a", "contradiction", "." ] } ]

PMC11791432

GBM cells, immune cells and normal cells were separated on Umap, and the ANXA1 expression was annotated with purple.

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PMC11025866

Candidates for repressors of EBV reactivation were identified as the expressed genes that overlapped between cells that were inhibited in EBV reactivation (i.e VPA and VPM-treated) and cellular transcripts that were excluded from reactivated cells (butyrate-treated).

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PMC11585994

Representative TEM images of G5 (left) and G5-sgc8-siBCL11B (right) nanoparticles. (

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PMC10936243

This could be done by asking the client to bring bedding or clothes for their pet which would help to maintain the familiar smell and scents of home for the cats (Ellis et al. 2013).

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PMC11576293

This experiment examines the impact of the newly developed compounds 9–29 on normal cell lines to assess their safety level.

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PMC10940855

Investigators were not blinded and no animals were excluded from the analysis.

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PMC9341513

Yellow blocks indicate regions with chromatin states associated with H3K27ac and indicate regions which have a more open chromatin structure in the model.

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PMC11490153

Citral, a monoterpene aldehyde and major compound in C. citratus EO, possesses various biological effects, including anticancer, antioxidant, and antibacterial activities .

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PMC11714165

Primary bone marrow cells were harvested from C57 mice (8‐week‐old) by flushing the cavities of the tibia and femur.

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PMC8592717

In experimentally developed chronic intermittent hypoxia rat models, PCA reversed the neurocognitive function impairment through modulation of synaptic plasticity, inhibition of ROS production, and neuronal apoptosis, as well as induction of glial cell proliferation and brain-derived neurotrophic factor (BDNF) expression .

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PMC11594588

Strong platelet activation characterized by a drastic increase in mitochondrial and cytosolic calcium also appears to initiate the collapse of the mitochondrial membrane potential (ΔΨ m) via a cyclophilin D (CypD)-dependent mechanism .

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PMC9268620

The melting point of nordamnacanthal was 214–218 °C, and damnacanthal was 208–211 °C.

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PMC9583612

Bridger measured this high tank emission coming from four emission locations on three closely located tanks on site.

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PMC11599565

Nested cells represent a unique cellular subpopulation capable of binary differentiation: on one hand, they maintain the condition of cancer stem cell in a small fraction (probably via multinucleation) as seen by the expression of stem cell markers like Oct-4, SOX2 and Klf-4 and, on the other hand, they differentiate towards an epithelial condition as seen by gradual loss of mesenchymal characteristics in parallel with the acquisition of the epithelial phenotype, thus shaping the cellular heterogeneity present in tumors (Fig. 5, Panel D, SF10).

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PMC11518702

Expression of HGAL (GFP-fusion), and of HGAL-GFP-Y107F, also differentially affected BCR-induced SMAC formation (8).

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PMC11765988

Key proteins involved in these changes include PSMA7, PSMB6, PSMA5, PSMA6, PSMB4, PSMA3, PSMB5, PSMA4, PSMB2, and PSMA2 .

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PMC9429973

A prior CLL, diagnosed in 2014-2019, was identified through cross-linkage with the NCR.

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PMC5363531

These preliminary observations prompted further investigations on the PI3K-Akt-mTOR pathway, with the hypothesis that SRC and TS modulation could converge in this signaling pathway.

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PMC9429973

Aims: The aims of this study are (i) to evaluate the capacity of a real-world program to provide high-quality data that translate into meaningful clinical endpoints, and (ii) to describe the demographic and clinical characteristics as well as therapeutic management and treatment effectiveness of 1 line (1L) DLBCL patients.

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PMC10669966

Higher PDE3A expression in MLPS was also seen in mRNA levels (Figure S1A), and a positive correlation between mRNA and protein expression was observed (Spearman’s ρ = 0.423, p < 0.001) (Figure S1B).

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PMC11659921

To enhance the verification of the possible roles of genes related to angiogenesis and stemness, functional enrichment analysis was performed on the data.

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PMC10854447

Anal.

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PMC11725127

GFP-KRAS was overexpressed in USP2 knockout RPMI 8226 cells and the indicated proteins were examined by Western blot. (

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PMC11592837

The study was conducted in accordance with the Declaration of Helsinki, and local ethics committee approval was obtained.

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PMC11548041

MNVs as well as other biologically derived nanovesicles can be loaded with exogenous cargo, such as non-coding RNAs, and deliver this bioactive cargo to recipient cells .

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PMC11078693

Slowly add 1 mL of PBS to the edge of the glass; strong flow can detach cells.

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PMC11796104

Whole blood was collected from patients using the same method as previously described.

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PMC11422150

As far as our investigation extends, a three-dimensional treadmill gait analysis system is the most sophisticated method.

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PMC11621493

Statistical comparison in all graphs was performed with an unpaired two-tailed Student’s t test.

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PMC11672142

The UV–vis spectra for the two in situ prepared solutions collected at 50 μM Fe(III) exhibit two distinct species (Figure S14) and were corrected for excess ligand in the respective solutions.

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PMC11727907

The anaerobic glycolysis yield was determined by calculating the percentage of real lactate released by ARPE-19 cells in the growth medium relative to the theoretical lactate production, calculated as twice the amount of glucose consumed (since, in exclusive anaerobic metabolism, one glucose molecule is converted into two lactate molecules) .

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PMC11707577

Spheroid disaggregation was evaluated by the acquisition of images with NIKON A1R confocal microscope as previously described.

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PMC9429973

After combination therapy, pts may continue with SA siremadlin maintenance.

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PMC3681794

HOS cells have an aberrantly activated PI3K pathway with strong expression of PTEN, Akt and pS473 Akt in both normoxia and hypoxia (data not shown).

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PMC9429973

At the end of the 4 courses, the pre-auto-SCT response was: CR 29 (27%), Partial Response (PR) 9 (17%); according to arm of randomization, the primary end point was not met, with CR 28% for R-DHAP and 26% for BR-DHAP (p-value 0.563).

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PMC11499955

The limits of detection and quantification in solution of each TMPP-tag were then determined by LC-MS/MS analysis and found to be ∼20 pM and ∼70 pM respectively in DMEM cell media, whatever is the tag isotopologue (Table S3†).

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PMC11670407

Subsequently, the samples were rinsed with propylene oxide and impregnated with epoxy resin.

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PMC11457557

This method has the potential to provide more locations for DVC genomic study.

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PMC9429973

We performed an international randomized phase III study to investigate the efficacy of rituximab when added to methotrexate, BCNU, teniposide and prednisolone (MBVP) in PCNSL.

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PMC11536589

Increased expression of MGST1 weakened the cytotoxicity of MRTX1133 by inhibiting lipid peroxidation-induced ferroptosis in KRAS inhibitor-resistant PDAC cells.

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PMC11687663

The energy minimum for both compounds is expected to be located at the point of contact with the initial lipid layer (about 2 nm).

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PMC10808409

Model analysis showed that the total Pluronic mixture (X1) and Pluronic P123% (X2) had significant effects on EE% and PS, while drug amount (X3) had a significant effect only on the EE%.

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PMC11562028

When cells undergo oxidative damage, it often leads to abnormal mitochondrial function.

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PMC11496728

The results of early optimization indicated that compared with the control vector expressing eGFP, the vector with the Kozak sequence, as well as the combined sequence of Kozak and Leader, was increased by 1.26- and 2.2-fold, respectively, and the fluorescence of pCMV-eGFP, pCMV-eGFP-1, and pCMV-eGFP-2 transfected with CHO-KO was remarkably enhanced compared with CHO-WT when expressing eGFP using the novel CHO cell expression system.

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PMC7917457

For the MAGE-A3 assay, CD8 T cells were presensitized with tumor antigen-containing peptide MAGE-A3(168−176).

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PMC11746942

Using genetic and pharmacological approaches, we reveal a novel S1PR3–Src–STAT3 signaling axis that drives both early and prolonged STAT3 activation in keratinocytes.

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PMC11637820

These foot ulcers occur when a particular area of the foot has been subjected to continuous pressure or trauma .

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PMC10743717

Whether such an inhibitor could effectively prevent mitochondrial dysfunction is considered an essential criteria for further investigation .

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PMC11322866

Taken together, these data show that RRM2 overexpression inhibits EZH2 methyltransferase activity and induces senescence in MM cells.

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PMC11672142

That the cell death capability of DefNEtTrp depends on its Fe-binding ability is further supported by the observation that cells presupplemented with Fe display higher resistance toward the cytotoxicity of the dual chelator.

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PMC11499381

These constructs are referred to as wild type (WT) throughout the manuscript.

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PMC11732635

The ileum and colon biopsy revealed EBV-positive lymphoproliferative disease.

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PMC10812665

It is possible that low test compound concentrations (≤BMC25NA) triggered a transient response between 4 and 16 h. Mitochondrial dysfunction, primary or secondary, is a common feature of neurodegeneration and neurotoxicity.

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PMC11621565

, Phorbol 12-Myristate 13-Acetate (PMA) (cat.no.

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PMC9454178

Annexin V/PI staining illustrated that the percentage of apoptotic cells significantly increased in a THZ1 dose-dependent manner (Fig. 3D, E).

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PMC9712534

The neurological defects in TOP2B knockout mice are currently ascribed to the perturbation of TOP2B-mediated gene expression.

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PMC9220170

Similar results were shown by Tanguy Y. et al. on endocrine cells .

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PMC9164404

Calcein AM/PI (acetyl methoxy methyl ester/propidium iodide) cell viability kit, DNA extraction kit and Annexin V-FITC apoptosis detection kit was purchased from Beyotime Institute of Biotechnology (Jiangsu, China).

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PMC11144200

2SO4-HEPES buffer was added for shock, then the liposome solution was ultrasound to transparency by ultrasonic crushing apparatus, and finally transferred to a dialysis bag with 10 kDa molecular weight interception for dialysis to prepare liposomes with ammonium sulfate gradient.

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PMC9429973

Aims: The primary aim was to assess the pattern of distribution of M-GVs, their correlations with SMF subtype and with driver mutations, in a large cohort of SMF patients studied by next generation sequencing (NGS).

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PMC4443654

Acc.,

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PMC11419566

Traditional Chinese medicine (TCM) has been practiced for thousands of years and is now widely recognized as a viable alternative cancer treatment.

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PMC11487720

UV/cold shock-treated L929S cells exhibited relocation of α-tubulin to the nuclear bubble (Fig. 5D, right panel; red arrows; also see an enlarged insert).

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PMC2193049

Finally, treatment of HLA-A*0201 melanoma cells expressing MAGE-3 with lactacystin or another proteasome inhibitor, N-acetyl-Leu-Leu-norleucinal (LLnL), restored the presentation of MAGE-3271–279.

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PMC9844987

However, when analyzing specifically multi-modal low variable promoters (containing at least two decomposed promoters), a strong +1 nucleosome was only observed for promoters with highly correlated decomposed promoters (Figure 4—figure supplement 2C and D).

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PMC11733919

Furthermore, to potentiate anti-CD26 antibody-mediated cytotoxicity, two HSP90 inhibitors 17-AAG (tanespimycin) and 17-DMAG (alvespimycin) with senolytic activity were loaded.

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PMC9503669

Thus, 2C may prevent Nef-mediated Src-family kinase activation through allosteric inhibition of kinase recruitment.

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PMC8348645

To this, 0.2 mL of concentrated sulphuric acid was added.

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PMC11659921

The classic OV biomarkers, carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4), can facilitate preliminary diagnosis; however, it is essential to acknowledge issues such as false positives and their limited prognostic predictive capability.

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PMC9429973

Cell viability and cellular growth was evaluated by viable counts and by Cell Titer Glo assay.

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PMC9429973

Clinical trial information: NCT05079230.

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PMC10994876

The cells were seeded on 96-well plates (7 × 10^3 cells/well) and transfected with overexpressing YAP5SA and control plasmids.

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PMC10854447

Anal.

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PMC11672142

This solution is light amber in color.

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PMC11711345

Data was acquired (10 gated events) with a FACScalibur flow cytometer and analyzed using CellQuestTM software (Becton Dickinson, Bioscience, San Jose, USA).

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PMC11476106

The media were changed every 2–3 days, and cultures were trypsinized when confluence was reached.

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PMC11769516

It is important to note that the permeability of mycotoxins, which, as single compounds, cannot penetrate the BBB, may be influenced by the supporting action of other substances including trichothecenes, which include DON and, by impairing the continuity of the barrier, enable them to reach the brain .

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PMC9429973

By applying this msPCR on a cohort of 613 CLL patients, our results corroborate the relevance of IGLV3-21 testing to improve the risk stratification of CLL patients in the clinical practice, especially within M-CLL and i-CLL subtypes.

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PMC11604768

Indeed, heterotypic TRE combinations with elevated transcriptional activity relative to homotypic promoters have been reported.

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PMC11244823

Horse sera differenciated by vaccination status (vac = vaccinated; n-vac = not vaccinted). (

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PMC11806106

This allows the recruitment of arrestins to the receptor, inducing internalization, degradation, or recycling of the receptors.

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