Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC11627398
Meanwhile, the proportions of 13 immune cells including naive B cells, CD8 T cells, resting CD4 memory T cells, activated CD4 memory T cells, follicular helper T cells, gamma delta T cells, resting NK cells, monocytes, M0 macrophages, resting dendritic cells, resting mast cells, activated mast cells and neutrophils were significantly altered between control and septic shock groups (Fig 5B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "the", "proportions", "of", "13", "immune", "cells", "including", "naive", "B", "cells", ",", "CD8", "T", "cells", ",", "resting", "CD4", "memory", "T", "cells", ",", "activated", "CD4", "memory", "T", "cells", ",", "follicular", "helper", "T", "cells", ",", "gamma", "delta", "T", "cells", ",", "resting", "NK", "cells", ",", "monocytes", ",", "M0", "macrophages", ",", "resting", "dendritic", "cells", ",", "resting", "mast", "cells", ",", "activated", "mast", "cells", "and", "neutrophils", "were", "significantly", "altered", "between", "control", "and", "septic", "shock", "groups", "(", "Fig", "5B", ")", "." ] } ]
PMC11718817
These APC-like NK cells then efficiently killed tumor cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "APC-like", "NK", "cells", "then", "efficiently", "killed", "tumor", "cells", "." ] } ]
PMC11632064
In contrast, anti-inflammatory cell lines (A-375, COLO 829, Malme-3M, and WM983B) showed enrichment in gene sets such as EMT, inflammation, and apoptosis (Fig 6A and C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "anti-inflammatory", "cell", "lines", "(", "A-375", ",", "COLO", "829", ",", "Malme-3", "M", ",", "and", "WM983B", ")", "showed", "enrichment", "in", "gene", "sets", "such", "as", "EMT", ",", "inflammation", ",", "and", "apoptosis", "(", "Fig", "6A", "and", "C", ")", "." ] } ]
PMC11695546
The minimum inhibitory concentration (MICs) were detected by visually measuring the specimens’ levels at which the standard strain's growth was completely inhibited.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "minimum", "inhibitory", "concentration", "(", "MICs", ")", "were", "detected", "by", "visually", "measuring", "the", "specimens", "’", "levels", "at", "which", "the", "standard", "strain", "'s", "growth", "was", "completely", "inhibited", "." ] } ]
PMC11544122
For each independent experiment, BRET was determined from the average of 6 consecutive reads (1–6 min) (e) or the average of three reads (4–6 min) (f).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "independent", "experiment", ",", "BRET", "was", "determined", "from", "the", "average", "of", "6", "consecutive", "reads", "(", "1–6", "min", ")", "(", "e", ")", "or", "the", "average", "of", "three", "reads", "(", "4–6", "min", ")", "(", "f", ")", "." ] } ]
PMC9429973
Seventy-three out of 101 patients (72%) had at least one variant with therapy sensitizing, diagnostic, or prognostic significance (levels A–C) or associated with therapy resistance (levels A/D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seventy-three", "out", "of", "101", "patients", "(", "72", "%", ")", "had", "at", "least", "one", "variant", "with", "therapy", "sensitizing", ",", "diagnostic", ",", "or", "prognostic", "significance", "(", "levels", "A", "–", "C", ")", "or", "associated", "with", "therapy", "resistance", "(", "levels", "A/D", ")", "." ] } ]
PMC10154881
Viruses are one of several growth strategies for cancer therapy as part of a large effort to modify candidate viruses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viruses", "are", "one", "of", "several", "growth", "strategies", "for", "cancer", "therapy", "as", "part", "of", "a", "large", "effort", "to", "modify", "candidate", "viruses", "." ] } ]
PMC10907726
To further investigate the underlying molecular mechanism of DATS on OS cells, the RNA sequencing (RNA-seq) method was used to analysis the differentially expressed genes in 143B cells treated with 100 μM DATS and NC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "investigate", "the", "underlying", "molecular", "mechanism", "of", "DATS", "on", "OS", "cells", ",", "the", "RNA", "sequencing", "(", "RNA-seq", ")", "method", "was", "used", "to", "analysis", "the", "differentially", "expressed", "genes", "in", "143B", "cells", "treated", "with", "100", "μM", "DATS", "and", "NC", "." ] } ]
PMC9429973
The worsening of anemia prompted re-evaluation of the case by t-NGS for RBC defects.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "worsening", "of", "anemia", "prompted", "re-evaluation", "of", "the", "case", "by", "t-NGS", "for", "RBC", "defects", "." ] } ]
PMC11680049
The dry plant extract residue was obtained from concentrated ethanol extracts of intact shoots of Sequoia and initiated from them third-passage callus tissue.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dry", "plant", "extract", "residue", "was", "obtained", "from", "concentrated", "ethanol", "extracts", "of", "intact", "shoots", "of", "Sequoia", "and", "initiated", "from", "them", "third-passage", "callus", "tissue", "." ] } ]
PMC7762347
As the mixture of CYN/MCLR showed a very similar pattern in the gene expression as well as induction of DNA damage when compared to pure CYN and no additive/synergistic effects could be noticed, it can be concluded that the observed changes are due to the effects of CYN alone, which presents by far greater risk for human exposure than MCLR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "the", "mixture", "of", "CYN/MCLR", "showed", "a", "very", "similar", "pattern", "in", "the", "gene", "expression", "as", "well", "as", "induction", "of", "DNA", "damage", "when", "compared", "to", "pure", "CYN", "and", "no", "additive/synergistic", "effects", "could", "be", "noticed", ",", "it", "can", "be", "concluded", "that", "the", "observed", "changes", "are", "due", "to", "the", "effects", "of", "CYN", "alone", ",", "which", "presents", "by", "far", "greater", "risk", "for", "human", "exposure", "than", "MCLR", "." ] } ]
PMC10944868
The final concentration of DMSO never exceeded 5% (v/v) in reactions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "final", "concentration", "of", "DMSO", "never", "exceeded", "5", "%", "(", "v/v", ")", "in", "reactions", "." ] } ]
PMC11686380
On the other hand, surprisingly, when this variant was expressed in primary cultured cortical neurons, its expression level was significantly lower than that of WT (Fig. 2B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "surprisingly", ",", "when", "this", "variant", "was", "expressed", "in", "primary", "cultured", "cortical", "neurons", ",", "its", "expression", "level", "was", "significantly", "lower", "than", "that", "of", "WT", "(", "Fig.", "2B", ")", "." ] } ]
PMC11755467
DICER assays were performed in 6 µL cell lysate, 1 µL radiolabeled RNA and the appropriate volume of Enoxacin (for the final concentration of 100 µM: 1:100 stock dilution; 300 µM: 1:33.3 stock dilution; 1000 µM: 1:10 stock dilution) or DMSO.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DICER", "assays", "were", "performed", "in", "6", "µL", "cell", "lysate", ",", "1", "µL", "radiolabeled", "RNA", "and", "the", "appropriate", "volume", "of", "Enoxacin", "(", "for", "the", "final", "concentration", "of", "100", "µM", ":", "1:100", "stock", "dilution", ";", "300", "µM", ":", "1:33.3", "stock", "dilution", ";", "1000", "µM", ":", "1:10", "stock", "dilution", ")", "or", "DMSO", "." ] } ]
PMC11612794
This is achieved by attaching sister chromatids to bipolar mitotic spindles, leading to chromosome segregation into daughter cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "achieved", "by", "attaching", "sister", "chromatids", "to", "bipolar", "mitotic", "spindles", ",", "leading", "to", "chromosome", "segregation", "into", "daughter", "cells", "." ] } ]
PMC11781181
Ferroptosis defense systems mainly include the GPX4-GSH, FSP1-CoQH2, dihydroorotate dehydrogenase (DHODH)-CoQH2, FTH1, and GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH4) systems 5.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferroptosis", "defense", "systems", "mainly", "include", "the", "GPX4-GSH", ",", "FSP1-CoQH2", ",", "dihydroorotate", "dehydrogenase", "(DHODH)-CoQH2", ",", "FTH1", ",", "and", "GTP", "cyclohydrolase", "1", "(GCH1)-tetrahydrobiopterin", "(", "BH4", ")", "systems", "5", "." ] } ]
PMC10758402
After 72 hours post-infection, fluorescence images were captured using the EVOS Live Cell Imaging System (Thermo Fisher) and cores were homogenized with a TissueLyser II (Qiagen) prior to titering.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "72", "hours", "post-infection", ",", "fluorescence", "images", "were", "captured", "using", "the", "EVOS", "Live", "Cell", "Imaging", "System", "(", "Thermo", "Fisher", ")", "and", "cores", "were", "homogenized", "with", "a", "TissueLyser", "II", "(", "Qiagen", ")", "prior", "to", "titering", "." ] } ]
PMC10165258
To distinguish distinct drug concentrations for each spheroid, a barcode strategy was implemented using fluorescent dyes (Figure 3E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "distinguish", "distinct", "drug", "concentrations", "for", "each", "spheroid", ",", "a", "barcode", "strategy", "was", "implemented", "using", "fluorescent", "dyes", "(", "Figure", "3E", ")", "." ] } ]
PMC11583690
After determining the optimal initial DTX concentration, this analysis was similar to the above-described solvent influence experiment, but DTX and nanomaterials were used at ratios of 1:1, 1:2, 1:3, 1:4, and 1:5 to determine the ratio with the highest loading efficiency and compare the two nanoparticle types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "determining", "the", "optimal", "initial", "DTX", "concentration", ",", "this", "analysis", "was", "similar", "to", "the", "above-described", "solvent", "influence", "experiment", ",", "but", "DTX", "and", "nanomaterials", "were", "used", "at", "ratios", "of", "1:1", ",", "1:2", ",", "1:3", ",", "1:4", ",", "and", "1:5", "to", "determine", "the", "ratio", "with", "the", "highest", "loading", "efficiency", "and", "compare", "the", "two", "nanoparticle", "types", "." ] } ]
PMC9429973
CD1a is a glycoprotein expressed on cortical T-ALL and only on healthy thymocytes and Langerhans cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD1a", "is", "a", "glycoprotein", "expressed", "on", "cortical", "T-ALL", "and", "only", "on", "healthy", "thymocytes", "and", "Langerhans", "cells", "." ] } ]
PMC11699465
TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRIM28", "promotes", "the", "escape", "of", "gastric", "cancer", "cells", "from", "immune", "surveillance", "by", "increasing", "PD-L1", "abundance", "." ] } ]
PMC11026382
We observed some variation in the fit parameters (relative to the older data in Fig. 1); this difference might be attributed to the fact that our newer experiments used a revised selection vector backbone.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "some", "variation", "in", "the", "fit", "parameters", "(", "relative", "to", "the", "older", "data", "in", "Fig.", "1", ")", ";", "this", "difference", "might", "be", "attributed", "to", "the", "fact", "that", "our", "newer", "experiments", "used", "a", "revised", "selection", "vector", "backbone", "." ] } ]
PMC9856122
These alkaloids possess numerous biological activities including antifungal, antidiabetic, anticancer, anti-inflammatory, antibacterial, and antiviral.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "alkaloids", "possess", "numerous", "biological", "activities", "including", "antifungal", ",", "antidiabetic", ",", "anticancer", ",", "anti-inflammatory", ",", "antibacterial", ",", "and", "antiviral", "." ] } ]
PMC10158546
A lack of accessible and useful in vitro models of prion infection has hampered progress towards identifying links between prion replication and toxicity, screening putative therapeutics, and characterizing prion strain diversity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "lack", "of", "accessible", "and", "useful", "in", "vitro", "models", "of", "prion", "infection", "has", "hampered", "progress", "towards", "identifying", "links", "between", "prion", "replication", "and", "toxicity", ",", "screening", "putative", "therapeutics", ",", "and", "characterizing", "prion", "strain", "diversity", "." ] } ]
PMC9952933
It is known that reactive oxidative species (ROS) produced in CAP are responsible for this effect.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "known", "that", "reactive", "oxidative", "species", "(", "ROS", ")", "produced", "in", "CAP", "are", "responsible", "for", "this", "effect", "." ] } ]
PMC10996034
These targets may enhance the efficacy of treatment and improve the prognosis of patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "targets", "may", "enhance", "the", "efficacy", "of", "treatment", "and", "improve", "the", "prognosis", "of", "patients", "." ] } ]
PMC6835428
Spheroids are defined as 3D structure grown from stem cells and consisting of organ-specific cell types .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spheroids", "are", "defined", "as", "3D", "structure", "grown", "from", "stem", "cells", "and", "consisting", "of", "organ-specific", "cell", "types", "." ] } ]
PMC11026382
To quantify the context dependence of mutational effects, we computed epistasis relative to WT TYMS for all DHFR mutations with measurable relative growth rates in each of the three TYMS backgrounds (2696 in total, see also methods) (Fig. 4, Supplementary Fig. 4, Supplementary Data 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "quantify", "the", "context", "dependence", "of", "mutational", "effects", ",", "we", "computed", "epistasis", "relative", "to", "WT", "TYMS", "for", "all", "DHFR", "mutations", "with", "measurable", "relative", "growth", "rates", "in", "each", "of", "the", "three", "TYMS", "backgrounds", "(", "2696", "in", "total", ",", "see", "also", "methods", ")", "(", "Fig.", "4", ",", "Supplementary", "Fig.", "4", ",", "Supplementary", "Data", "2", ")", "." ] } ]
PMC11583010
All calibration standards, Quality Control (QC) samples, and data points were analyzed in duplicate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "calibration", "standards", ",", "Quality", "Control", "(", "QC", ")", "samples", ",", "and", "data", "points", "were", "analyzed", "in", "duplicate", "." ] } ]
PMC11767817
However, despite its broad anticancer potential, the clinical application of curcumin in cancer treatment is limited by several factors, including low water solubility, poor stability, insufficient bioactivity in cancer cells, loss of therapeutic efficiency, and lack of selectivity toward tumor cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "despite", "its", "broad", "anticancer", "potential", ",", "the", "clinical", "application", "of", "curcumin", "in", "cancer", "treatment", "is", "limited", "by", "several", "factors", ",", "including", "low", "water", "solubility", ",", "poor", "stability", ",", "insufficient", "bioactivity", "in", "cancer", "cells", ",", "loss", "of", "therapeutic", "efficiency", ",", "and", "lack", "of", "selectivity", "toward", "tumor", "cells", "." ] } ]
PMC5261804
A Cox proportional hazards analysis was then used to measure the prognostic significance of these groups.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Cox", "proportional", "hazards", "analysis", "was", "then", "used", "to", "measure", "the", "prognostic", "significance", "of", "these", "groups", "." ] } ]
PMC9856122
ex DC.
[ { "tags": [ "O", "O", "O" ], "tokens": [ "ex", "DC", "." ] } ]
PMC9429973
Subsets defined by aberrant light chain production up-regulated the pathways related to neutrophil degranulation, transportation to and modifications in the Golgi apparatus, and asparagine N-linked protein glycosylation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsets", "defined", "by", "aberrant", "light", "chain", "production", "up-regulated", "the", "pathways", "related", "to", "neutrophil", "degranulation", ",", "transportation", "to", "and", "modifications", "in", "the", "Golgi", "apparatus", ",", "and", "asparagine", "N-linked", "protein", "glycosylation", "." ] } ]
PMC11224020
Right, box plots showing the minimum to maximum range of CCR7 intensity (N = 3; n = 54 cells (LmnA/C), n = 60 cells (LmnA/C)).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "box", "plots", "showing", "the", "minimum", "to", "maximum", "range", "of", "CCR7", "intensity", "(", "N", "=", "3", ";", "n", "=", "54", "cells", "(", "LmnA/C", ")", ",", "n", "=", "60", "cells", "(", "LmnA/C", ")", ")", "." ] } ]
PMC11748618
Therefore, we highlight the need for large-scale sequencing studies in people living with HIV and individuals of African ancestry to assess the impact of genetically regulated CHD1L expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "highlight", "the", "need", "for", "large-scale", "sequencing", "studies", "in", "people", "living", "with", "HIV", "and", "individuals", "of", "African", "ancestry", "to", "assess", "the", "impact", "of", "genetically", "regulated", "CHD1L", "expression", "." ] } ]
PMC10823017
: PKC-ζ is associated with c-Myc in both 786-0 and Caki-1 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ ":", "PKC-ζ", "is", "associated", "with", "c-Myc", "in", "both", "786", "-", "0", "and", "Caki-1", "cells", "." ] } ]
PMC10253973
A complex of Ru(II) with dipyrido [3,2-a:20.30c]phenazine and 2,2-bipyridine (57) is unique as the ligand positively influences cellular uptake.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complex", "of", "Ru(II", ")", "with", "dipyrido", "[3,2-a:20.30c]phenazine", "and", "2,2-bipyridine", "(", "57", ")", "is", "unique", "as", "the", "ligand", "positively", "influences", "cellular", "uptake", "." ] } ]
PMC10810426
DNA/RNA hybrids co-localized with MLV nucleocapsid (NC) at the nuclear membrane, and cytoplasm of infected but not uninfected cells; low levels of co-localization were also seen in the nucleus (Fig 2E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA/RNA", "hybrids", "co-localized", "with", "MLV", "nucleocapsid", "(", "NC", ")", "at", "the", "nuclear", "membrane", ",", "and", "cytoplasm", "of", "infected", "but", "not", "uninfected", "cells", ";", "low", "levels", "of", "co-localization", "were", "also", "seen", "in", "the", "nucleus", "(", "Fig", "2E", ")", "." ] } ]
PMC6643347
Among the resin acids, three components corresponding to the structural formula of C20H30O2 (1.6 μg/g) were found in the analyzed sample.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "resin", "acids", ",", "three", "components", "corresponding", "to", "the", "structural", "formula", "of", "C20H30O2", "(", "1.6", "μg/g", ")", "were", "found", "in", "the", "analyzed", "sample", "." ] } ]
PMC6934009
The micro¬scopic observation showed rounding of A427 cells on treatment with wogonin (Figure 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "micro¬scopic", "observation", "showed", "rounding", "of", "A427", "cells", "on", "treatment", "with", "wogonin", "(", "Figure", "2", ")", "." ] } ]
PMC9429973
Ascites.
[ { "tags": [ "O", "O" ], "tokens": [ "Ascites", "." ] } ]
PMC11180402
A-B miR-129 (A) and SHNG1 (B) expression in 5637 (vector) and 5637 (miR-129) cells by RT-qPCR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-B", "miR-129", "(", "A", ")", "and", "SHNG1", "(", "B", ")", "expression", "in", "5637", "(", "vector", ")", "and", "5637", "(", "miR-129", ")", "cells", "by", "RT-qPCR", "." ] } ]
PMC11680578
Subsequently, the proteins were transferred onto a nitrocellulose membrane.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "proteins", "were", "transferred", "onto", "a", "nitrocellulose", "membrane", "." ] } ]
PMC9429973
Aims: To evaluate the prognostic role of FXI in aPL Methods: Cross-sectional and observational study of aPL patients ≥ 18 years recruited in a single center.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "evaluate", "the", "prognostic", "role", "of", "FXI", "in", "aPL", "Methods", ":", "Cross-sectional", "and", "observational", "study", "of", "aPL", "patients", "≥", "18", "years", "recruited", "in", "a", "single", "center", "." ] } ]
PMC9429973
Aims: The purpose of the study was the evaluation of cellular aging in children and adolescents with ALL, determined by the telomere length measurement, as well as the possible correlation with the response to treatment, the risk of relapse and ultimately the overall survival.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "purpose", "of", "the", "study", "was", "the", "evaluation", "of", "cellular", "aging", "in", "children", "and", "adolescents", "with", "ALL", ",", "determined", "by", "the", "telomere", "length", "measurement", ",", "as", "well", "as", "the", "possible", "correlation", "with", "the", "response", "to", "treatment", ",", "the", "risk", "of", "relapse", "and", "ultimately", "the", "overall", "survival", "." ] } ]
PMC11727306
This is not surprising because it shows what would be expected from a potent inhibitor of protein synthesis that is affected via abrin A chain cleavage of the 28s rRNA of the 60s ribosomal subunit.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "not", "surprising", "because", "it", "shows", "what", "would", "be", "expected", "from", "a", "potent", "inhibitor", "of", "protein", "synthesis", "that", "is", "affected", "via", "abrin", "A", "chain", "cleavage", "of", "the", "28s", "rRNA", "of", "the", "60s", "ribosomal", "subunit", "." ] } ]
PMC11714165
The standard chemotherapeutic options for osteosarcoma are cisplatin, methotrexate, and doxorubicin which have been used for more than 40 years in clinics.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "standard", "chemotherapeutic", "options", "for", "osteosarcoma", "are", "cisplatin", ",", "methotrexate", ",", "and", "doxorubicin", "which", "have", "been", "used", "for", "more", "than", "40", "years", "in", "clinics", "." ] } ]
PMC11381192
Correlation analysis of CSI in predicting chemotherapeutic sensitivity and immunotherapy response. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "analysis", "of", "CSI", "in", "predicting", "chemotherapeutic", "sensitivity", "and", "immunotherapy", "response", ".", "(" ] } ]
PMC7759933
These results again show that spheroids with lower initial density maintain a higher rate of cell proliferation compared to spheroids with higher initial density.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "again", "show", "that", "spheroids", "with", "lower", "initial", "density", "maintain", "a", "higher", "rate", "of", "cell", "proliferation", "compared", "to", "spheroids", "with", "higher", "initial", "density", "." ] } ]
PMC10454535
This may suggest the interactions between PIN and BTZ differentially affect MM cell viability across cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "may", "suggest", "the", "interactions", "between", "PIN", "and", "BTZ", "differentially", "affect", "MM", "cell", "viability", "across", "cell", "lines", "." ] } ]
PMC11335267
Mice were acclimatized by subjecting them to handling and sham injections, and on the day previous to the test they were fasted overnight.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "were", "acclimatized", "by", "subjecting", "them", "to", "handling", "and", "sham", "injections", ",", "and", "on", "the", "day", "previous", "to", "the", "test", "they", "were", "fasted", "overnight", "." ] } ]
PMC11506670
Mutant HRAS, on the other hand, is most common in dermatological and head and neck cancers .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutant", "HRAS", ",", "on", "the", "other", "hand", ",", "is", "most", "common", "in", "dermatological", "and", "head", "and", "neck", "cancers", "." ] } ]
PMC11271278
The coverslips were then washed with 50% formamide/1×SSC for 4 min and dehydrated through a series of ethanol incubations (70%, 85%, and 100%) for 2 min each.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "coverslips", "were", "then", "washed", "with", "50", "%", "formamide/1", "×", "SSC", "for", "4", "min", "and", "dehydrated", "through", "a", "series", "of", "ethanol", "incubations", "(", "70", "%", ",", "85", "%", ",", "and", "100", "%", ")", "for", "2", "min", "each", "." ] } ]
PMC9429973
Biol.
[ { "tags": [ "O", "O" ], "tokens": [ "Biol", "." ] } ]
PMC11696576
We did not identify any transcripts with differential RO, indicating that AVX420 did not affect translation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "did", "not", "identify", "any", "transcripts", "with", "differential", "RO", ",", "indicating", "that", "AVX420", "did", "not", "affect", "translation", "." ] } ]
PMC8996378
MDR refers to the resistance of cancer cells to various chemotherapy drugs with different structures and mechanisms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MDR", "refers", "to", "the", "resistance", "of", "cancer", "cells", "to", "various", "chemotherapy", "drugs", "with", "different", "structures", "and", "mechanisms", "." ] } ]
PMC9960565
The other reagents used in the synthesis were obtained from Acros organics or Fisher Scientific.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "other", "reagents", "used", "in", "the", "synthesis", "were", "obtained", "from", "Acros", "organics", "or", "Fisher", "Scientific", "." ] } ]
PMC4839679
During the QC step, Agilent 2100 Bioanalyzer and ABI StepOnePlus Real-Time PCR System were used to qualify and quantify the sample libraries.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "QC", "step", ",", "Agilent", "2100", "Bioanalyzer", "and", "ABI", "StepOnePlus", "Real-Time", "PCR", "System", "were", "used", "to", "qualify", "and", "quantify", "the", "sample", "libraries", "." ] } ]
PMC3019555
Cells were transfected with 0.40 µg shNA using FuGENE 6 transfection reagent (Roche) for 48 h followed by puromycin selection to generate stable transfections.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "transfected", "with", "0.40", "µg", "shNA", "using", "FuGENE", "6", "transfection", "reagent", "(", "Roche", ")", "for", "48", "h", "followed", "by", "puromycin", "selection", "to", "generate", "stable", "transfections", "." ] } ]
PMC11802929
Legend on the bottom.
[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Legend", "on", "the", "bottom", "." ] } ]
PMC6442998
Based on our original observations in GIST48 cells, a phase I clinical trial (« cilostazol as imatinib synergiser in patients with unresectable or metastatic GIST treated by Glivec® » - CILOGIST - EudraCT: 2018-001295-37), has been recently (October 2018) initiated at the Erasme Academic Hospital, Université Libre de Bruxelles, Belgium (Prof. Jean-Luc Van Laethem & Dr. Anne Demols, Clinique d’Oncologie Digestive, Service de Gastroentérologie, Prof. Jacques Devière).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "our", "original", "observations", "in", "GIST48", "cells", ",", "a", "phase", "I", "clinical", "trial", "(", "«", "cilostazol", "as", "imatinib", "synergiser", "in", "patients", "with", "unresectable", "or", "metastatic", "GIST", "treated", "by", "Glivec", "®", "»", "-", "CILOGIST", "-", "EudraCT", ":", "2018", "-", "001295", "-", "37", ")", ",", "has", "been", "recently", "(", "October", "2018", ")", "initiated", "at", "the", "Erasme", "Academic", "Hospital", ",", "Université", "Libre", "de", "Bruxelles", ",", "Belgium", "(", "Prof.", "Jean-Luc", "Van", "Laethem", "&", "Dr.", "Anne", "Demols", ",", "Clinique", "d’Oncologie", "Digestive", ",", "Service", "de", "Gastroentérologie", ",", "Prof.", "Jacques", "Devière", ")", "." ] } ]
PMC11678368
The arrangement of ligands significantly affects vibrational modes related to the metal–ligand bonds.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "arrangement", "of", "ligands", "significantly", "affects", "vibrational", "modes", "related", "to", "the", "metal", "–", "ligand", "bonds", "." ] } ]
PMC10362265
According to maximum ASA (maxASA) values of amino acids , , , a cysteine can reach an average of maxASA of 150 Å and a serine could reach an average of 137 Å. Given these maxASA values for cysteine and serine amino acids, the 74th positions became completely accessible in all simulations except those of the computed models (Fig. 4a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "maximum", "ASA", "(", "maxASA", ")", "values", "of", "amino", "acids", ",", ",", ",", "a", "cysteine", "can", "reach", "an", "average", "of", "maxASA", "of", "150", "Å", "and", "a", "serine", "could", "reach", "an", "average", "of", "137", "Å.", "Given", "these", "maxASA", "values", "for", "cysteine", "and", "serine", "amino", "acids", ",", "the", "74th", "positions", "became", "completely", "accessible", "in", "all", "simulations", "except", "those", "of", "the", "computed", "models", "(", "Fig.", "4a", ")", "." ] } ]
PMC9100622
It has also been suggested, though not yet formally proven, that increased ROS levels may be a cause of statin-induced myopathy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "also", "been", "suggested", ",", "though", "not", "yet", "formally", "proven", ",", "that", "increased", "ROS", "levels", "may", "be", "a", "cause", "of", "statin-induced", "myopathy", "." ] } ]
PMC11172027
Moreover, NASeLM could be a potential drug for the treatment of poorly differentiated thyroid cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "NASeLM", "could", "be", "a", "potential", "drug", "for", "the", "treatment", "of", "poorly", "differentiated", "thyroid", "cancer", "." ] } ]
PMC11718809
MYLK2, TPCN1, and CACNA1E were mapped to the calcium signaling pathway, while PYCR1 and SMOX were mapped to the arginine and proline metabolism pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYLK2", ",", "TPCN1", ",", "and", "CACNA1E", "were", "mapped", "to", "the", "calcium", "signaling", "pathway", ",", "while", "PYCR1", "and", "SMOX", "were", "mapped", "to", "the", "arginine", "and", "proline", "metabolism", "pathway", "." ] } ]
PMC11637716
The latter was continued in combination with sildenafil treatment after discharge at the age of 10 weeks.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "latter", "was", "continued", "in", "combination", "with", "sildenafil", "treatment", "after", "discharge", "at", "the", "age", "of", "10", "weeks", "." ] } ]
PMC11644761
Cell nuclei were stained with DAPI (blue).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "nuclei", "were", "stained", "with", "DAPI", "(", "blue", ")", "." ] } ]
PMC11779960
Grey bars indicate % of patients for each indication showing no TCRβ clonotype above 25% threshold.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grey", "bars", "indicate", "%", "of", "patients", "for", "each", "indication", "showing", "no", "TCRβ", "clonotype", "above", "25", "%", "threshold", "." ] } ]
PMC9429973
Methods: Primary pt data was obtained from six study groups: 98 from ALFA, 104 AMLCG, 191 HOVON, 200 MLL, 240 SAL, 177 UK(MRC/NCRI).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Primary", "pt", "data", "was", "obtained", "from", "six", "study", "groups", ":", "98", "from", "ALFA", ",", "104", "AMLCG", ",", "191", "HOVON", ",", "200", "MLL", ",", "240", "SAL", ",", "177", "UK(MRC/NCRI", ")", "." ] } ]
PMC9429973
Methods:: 94 bone marrow samples of younger (<65 years) AML patients have been collected.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", ":", "94", "bone", "marrow", "samples", "of", "younger", "(", "<", "65", "years", ")", "AML", "patients", "have", "been", "collected", "." ] } ]
PMC9646302
No significant changes in the weight of the mice were observed (Figure 4(a)), and the tumor volume in the LAMPT5-overexpression group was larger than that in the control group (Figure 4(b)).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "changes", "in", "the", "weight", "of", "the", "mice", "were", "observed", "(", "Figure", "4(a", ")", ")", ",", "and", "the", "tumor", "volume", "in", "the", "LAMPT5-overexpression", "group", "was", "larger", "than", "that", "in", "the", "control", "group", "(", "Figure", "4(b", ")", ")", "." ] } ]
PMC9429973
We analysed the clinico-hematological profile and treatment outcome of patients above 60 years diagnosed with AML during a period of four years in a single centre.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "analysed", "the", "clinico-hematological", "profile", "and", "treatment", "outcome", "of", "patients", "above", "60", "years", "diagnosed", "with", "AML", "during", "a", "period", "of", "four", "years", "in", "a", "single", "centre", "." ] } ]
PMC11676674
Conversely, a diterpene isolated from a hexane extract of C. monspeliensis leaves did not display any cytotoxic or cytostatic activity against the same nine cell lines tested .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "a", "diterpene", "isolated", "from", "a", "hexane", "extract", "of", "C.", "monspeliensis", "leaves", "did", "not", "display", "any", "cytotoxic", "or", "cytostatic", "activity", "against", "the", "same", "nine", "cell", "lines", "tested", "." ] } ]
PMC10671321
Cells were lysed 4 days after infection for analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "lysed", "4", "days", "after", "infection", "for", "analysis", "." ] } ]
PMC11519567
Further, we examined the distribution of SS18 protein and SS18-SSX1 protein in synovial sarcoma HS-SY-II cells expressing SS18-SSX1 protein.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "we", "examined", "the", "distribution", "of", "SS18", "protein", "and", "SS18-SSX1", "protein", "in", "synovial", "sarcoma", "HS-SY-II", "cells", "expressing", "SS18-SSX1", "protein", "." ] } ]
PMC11680049
This observation correlates with the staining using the Fast Blue reagent, which indicates the total content of soluble phenolic compounds.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "observation", "correlates", "with", "the", "staining", "using", "the", "Fast", "Blue", "reagent", ",", "which", "indicates", "the", "total", "content", "of", "soluble", "phenolic", "compounds", "." ] } ]
PMC9429973
Overall survival (OS) was estimated using the Kaplan-Meier method.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", "survival", "(", "OS", ")", "was", "estimated", "using", "the", "Kaplan-Meier", "method", "." ] } ]
PMC11078693
Cell detachment from the cover glass at Step 7d.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "detachment", "from", "the", "cover", "glass", "at", "Step", "7d", "." ] } ]
PMC11612626
MMCLs were pretreated with compound A and probed for the effect on apoptosis mediated by healthy, human allogeneic CD8 cytotoxic T cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MMCLs", "were", "pretreated", "with", "compound", "A", "and", "probed", "for", "the", "effect", "on", "apoptosis", "mediated", "by", "healthy", ",", "human", "allogeneic", "CD8", "cytotoxic", "T", "cells", "." ] } ]
PMC11742290
GA007 PDX tumor tissues (n = 3) Abbreviation: 4-Acetylantroquinonol B (4-AAQB), chimeric antigen receptor T (CAR-T), colorectal cancer (CRC), High grade serous ovarian carcinoma (HGSOC), Neuronal precursor cells developmentally downregulated protein 4 (NEDD4), Patient derived xenograft (PDX), R-spondin 1 (RSPO1), Trichosanthin (TCS), Verrucarin J (VJ) 4-Acetylantroquinonol B (4-AAQB) is a bioactive isolate from a Taiwanese mushroom with documented anti-inflammation, hypoglycaemic, vasorelaxant, and recently demonstrated antiproliferative activity .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GA007", "PDX", "tumor", "tissues", "(", "n", "=", "3", ")", "Abbreviation", ":", "4-Acetylantroquinonol", "B", "(", "4-AAQB", ")", ",", "chimeric", "antigen", "receptor", "T", "(", "CAR-T", ")", ",", "colorectal", "cancer", "(", "CRC", ")", ",", "High", "grade", "serous", "ovarian", "carcinoma", "(", "HGSOC", ")", ",", "Neuronal", "precursor", "cells", "developmentally", "downregulated", "protein", "4", "(", "NEDD4", ")", ",", "Patient", "derived", "xenograft", "(", "PDX", ")", ",", "R-spondin", "1", "(", "RSPO1", ")", ",", "Trichosanthin", "(", "TCS", ")", ",", "Verrucarin", "J", "(", "VJ", ")", "4-Acetylantroquinonol", "B", "(", "4-AAQB", ")", "is", "a", "bioactive", "isolate", "from", "a", "Taiwanese", "mushroom", "with", "documented", "anti-inflammation", ",", "hypoglycaemic", ",", "vasorelaxant", ",", "and", "recently", "demonstrated", "antiproliferative", "activity", "." ] } ]
PMC11727306
In these immune cells abrin toxin promotes ribosomal activity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "these", "immune", "cells", "abrin", "toxin", "promotes", "ribosomal", "activity", "." ] } ]
PMC11604768
Because many resulting p-values and false discovery rates were less than 10 and were thus outputted as zeros, we have chosen to display the resulting LRT statistic in our volcano plots.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "many", "resulting", "p-values", "and", "false", "discovery", "rates", "were", "less", "than", "10", "and", "were", "thus", "outputted", "as", "zeros", ",", "we", "have", "chosen", "to", "display", "the", "resulting", "LRT", "statistic", "in", "our", "volcano", "plots", "." ] } ]
PMC11665584
Clinical efforts to improve cutaneous wound healing have largely revolved around improving existing bandaging or skin-grafting technologies, but development of targeted therapeutics that potentiate the natural healing process has been stagnant (76).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "efforts", "to", "improve", "cutaneous", "wound", "healing", "have", "largely", "revolved", "around", "improving", "existing", "bandaging", "or", "skin-grafting", "technologies", ",", "but", "development", "of", "targeted", "therapeutics", "that", "potentiate", "the", "natural", "healing", "process", "has", "been", "stagnant", "(", "76", ")", "." ] } ]
PMC9429973
Serum iron, EPO, hepcidin and erythroferrone (ERFE) measurements were done by ELISA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serum", "iron", ",", "EPO", ",", "hepcidin", "and", "erythroferrone", "(", "ERFE", ")", "measurements", "were", "done", "by", "ELISA", "." ] } ]
PMC10728535
By eliminating outliers and inconsistent sample arrays, data sets were normalized with 57 sample arrays, which were considered for more downstream analyses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "eliminating", "outliers", "and", "inconsistent", "sample", "arrays", ",", "data", "sets", "were", "normalized", "with", "57", "sample", "arrays", ",", "which", "were", "considered", "for", "more", "downstream", "analyses", "." ] } ]
PMC11496491
The bubble chart analysis of most significant in terms of molecular function.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bubble", "chart", "analysis", "of", "most", "significant", "in", "terms", "of", "molecular", "function", "." ] } ]
PMC11768927
Notably, several strains feature a substitution (M51R) or a deletion (rVSVΔM51) at position 51 of the M protein.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "several", "strains", "feature", "a", "substitution", "(", "M51R", ")", "or", "a", "deletion", "(", "rVSVΔM51", ")", "at", "position", "51", "of", "the", "M", "protein", "." ] } ]
PMC11424574
Treatment with or without 200 ng/ml Recombinant uPA (Rh-uPA) protein in shLuc and shMTA2-osteosarcoma cells for 24 h was done, then measured the cell migration and invasion abilities by in vitro cell migration and invasion assay.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "or", "without", "200", "ng/ml", "Recombinant", "uPA", "(", "Rh-uPA", ")", "protein", "in", "shLuc", "and", "shMTA2-osteosarcoma", "cells", "for", "24", "h", "was", "done", ",", "then", "measured", "the", "cell", "migration", "and", "invasion", "abilities", "by", "in", "vitro", "cell", "migration", "and", "invasion", "assay", "." ] } ]
PMC11754784
The simulation result shows that type I leakage increases with increased concentration of target cells while type II leakage increases with increased concentration of by-standing cells (Fig. 5c).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "simulation", "result", "shows", "that", "type", "I", "leakage", "increases", "with", "increased", "concentration", "of", "target", "cells", "while", "type", "II", "leakage", "increases", "with", "increased", "concentration", "of", "by-standing", "cells", "(", "Fig.", "5c", ")", "." ] } ]
PMC11770130
We found that NTS treatment upregulated the expression of Gdf15 in the SVF-derived primary adipocytes compared to the vehicle treatment, but this phenotype was abolished in the cells with CerS2 knockdown (Fig. 6a; Supplementary information, Fig. S9c) or with the treatment of RhoAa (Supplementary information, Fig. S9d).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "NTS", "treatment", "upregulated", "the", "expression", "of", "Gdf15", "in", "the", "SVF-derived", "primary", "adipocytes", "compared", "to", "the", "vehicle", "treatment", ",", "but", "this", "phenotype", "was", "abolished", "in", "the", "cells", "with", "CerS2", "knockdown", "(", "Fig.", "6a", ";", "Supplementary", "information", ",", "Fig.", "S9c", ")", "or", "with", "the", "treatment", "of", "RhoAa", "(", "Supplementary", "information", ",", "Fig.", "S9d", ")", "." ] } ]
PMC10040136
Data are means ± SEM (n = 3 in each group) *p < 0.05; **p < 0.01 MSC-secreted TGF-β2 activates the PI3K-AKT signaling pathway in GIST cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "means", "±", "SEM", "(", "n", "=", "3", "in", "each", "group", ")", "*", "p", "<", "0.05", ";", "*", "*", "p", "<", "0.01", "MSC-secreted", "TGF-β2", "activates", "the", "PI3K-AKT", "signaling", "pathway", "in", "GIST", "cells", "." ] } ]
PMC11461833
STXBP5 and progerin have synergistic effects and a protein-protein interaction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STXBP5", "and", "progerin", "have", "synergistic", "effects", "and", "a", "protein-protein", "interaction", "." ] } ]
PMC11612794
Representative data of technical replicates are presented.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "data", "of", "technical", "replicates", "are", "presented", "." ] } ]
PMC10988555
The antiproliferative activity of complexes 1–4 was also tested in healthy human cells (fibroblasts) using a range of concentration of 0.1–100 μM (Figure S8).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "antiproliferative", "activity", "of", "complexes", "1–4", "was", "also", "tested", "in", "healthy", "human", "cells", "(", "fibroblasts", ")", "using", "a", "range", "of", "concentration", "of", "0.1–100", "μM", "(", "Figure", "S8", ")", "." ] } ]
PMC11536589
The lipid peroxidation was assessed by BODIPY 581/591 C11 probe using a flow cytometer after the 0.2 µM PKF-118-310 treatment for 48 h. (F) The intracellular MDA level was assessed after the 0.2 µM PKF-118-310 treatment for 48 h. (G) The intracellular GSH level was assessed after the 0.2 µM PKF-118-310 treatment for 48 h. (H) The effects of PKF-118-310 on the cell viabilities after Erastin or MRTX1133 treatment were assessed by CCK8 assay.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lipid", "peroxidation", "was", "assessed", "by", "BODIPY", "581/591", "C11", "probe", "using", "a", "flow", "cytometer", "after", "the", "0.2", "µM", "PKF-118", "-", "310", "treatment", "for", "48", "h.", "(", "F", ")", "The", "intracellular", "MDA", "level", "was", "assessed", "after", "the", "0.2", "µM", "PKF-118", "-", "310", "treatment", "for", "48", "h.", "(", "G", ")", "The", "intracellular", "GSH", "level", "was", "assessed", "after", "the", "0.2", "µM", "PKF-118", "-", "310", "treatment", "for", "48", "h.", "(", "H", ")", "The", "effects", "of", "PKF-118", "-", "310", "on", "the", "cell", "viabilities", "after", "Erastin", "or", "MRTX1133", "treatment", "were", "assessed", "by", "CCK8", "assay", "." ] } ]
PMC10135767
The flow chamber (working space: length × width × height = 2 × 0.5 × 0.0254 cm) was functionalized using the method outlined in previous studies .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "flow", "chamber", "(", "working", "space", ":", "length", "×", "width", "×", "height", "=", "2", "×", "0.5", "×", "0.0254", "cm", ")", "was", "functionalized", "using", "the", "method", "outlined", "in", "previous", "studies", "." ] } ]
PMC11748363
Color coding denotes antimycobacterial activity against Mtb H37Ra (MIC in μg/mL), darker means more active; numbers indicate the selectivity index SI = HepG2 IC50 (μM)/MIC MtbH37Ra (μM), calculated for compounds with MIC ≤ 31.25 μg/mL. Aside from Mtb H37Ra and H37Rv, only three compounds 3, 21, and 27 showed moderate activity (MIC = 15.625 μg/mL) on M. aurum or M. smegmatis (see Table 1), while compound 21 showed additional activity on M. kansasii and M. avium (see Table 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Color", "coding", "denotes", "antimycobacterial", "activity", "against", "Mtb", "H37Ra", "(", "MIC", "in", "μg/mL", ")", ",", "darker", "means", "more", "active", ";", "numbers", "indicate", "the", "selectivity", "index", "SI", "=", "HepG2", "IC50", "(μM)/MIC", "MtbH37Ra", "(", "μM", ")", ",", "calculated", "for", "compounds", "with", "MIC", "≤", "31.25", "μg/mL.", "Aside", "from", "Mtb", "H37Ra", "and", "H37Rv", ",", "only", "three", "compounds", "3", ",", "21", ",", "and", "27", "showed", "moderate", "activity", "(", "MIC", "=", "15.625", "μg/mL", ")", "on", "M.", "aurum", "or", "M.", "smegmatis", "(", "see", "Table", "1", ")", ",", "while", "compound", "21", "showed", "additional", "activity", "on", "M.", "kansasii", "and", "M.", "avium", "(", "see", "Table", "2", ")", "." ] } ]
PMC11089031
A The UMAP plots show the expression pattern of ZNF692 in all cell types from all samples.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "The", "UMAP", "plots", "show", "the", "expression", "pattern", "of", "ZNF692", "in", "all", "cell", "types", "from", "all", "samples", "." ] } ]
PMC10440586
2 CD99 is overexpressed in hypoxia adaptation process of gliomas. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2", "CD99", "is", "overexpressed", "in", "hypoxia", "adaptation", "process", "of", "gliomas", ".", "(" ] } ]