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OTAR3088
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PMC6222726
The extract showed strong activity against Leishmania mexicana both in the in vitro and in vivo tests.
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PMC11798926
Like SynDIG1, we observed very little surface expression of WT SynDIG2; however, to our surprise, we observed a significant increase in surface expression of the SynDIG2 135–55 deletion mutant, which is roughly equivalent to the SynDIG1 161–76 deletion mutant (F = 549.8, p < 0.0001) (Figure 2B,).
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PMC5443223
Early recognition and therapeutic intervention is extremely important in the prevention of heart failure.
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PMC11543885
Due to rapid labeling kinetics, the peroxidase is preferentially used for the profiling of fast biological processes, such as enzyme-substrate interactions, ligand-receptor pairings, and signaling complex assembly.
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PMC9429973
Our initial screening of AML datasets for LSC-associated genes identified Serine Protease Inhibitor Kazal type 2 (SPINK2) with high expression in AML, particularly in LSC fractions.
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PMC11765879
We herein report that there is a significant reduction in cell viability after treatment in both cell lines, which is consistent with previous studies that showed the cytotoxic effect of ZSC extracts against other subtypes of breast cancer, such as estrogen-positive and triple-negative .
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PMC10170482
We utilized the tetraethylbenzimidazolylcarbocyanine iodide-based (JC-1) fluorescent probe and confocal microscopy to measure mitochondrial membrane potential in cells grown under MC and CS conditions.
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PMC11539788
For the generation of stable cell lines, BCa cells were plated in 6-well plates and cultured to reach a confluence of approximately 40–50%.
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PMC9454852
The World Health Organization (WHO) assesses that in the world every year, more than 100,000 deaths are asbestos-related (i.e., asbestosis, lung cancer, and mesothelioma).
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PMC11682172
Breast cancer cell lines were cultured in RPMI-1640 with L-glutamine (BioWhittaker) medium supplemented with 10% FBS and 1% P/S, and 1% gentamicin was added to the breast cancer cells.
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PMC9429973
V. Ramos De Ascanio, L. Sánchez Paz, M. S. Infante, J. Churruca Sarasqueta, M. Á. Foncillas García, E. Landete Hernández, K. D. C. Marín Mori, C. Muñoz Novas, J. Á. Hernández Rivas, I. González Gascón y Marín Hematology, Infanta Leonor University Hospital, Madrid, Spain Background: Interim scan evaluation is a common practice during the treatment of some types of lymphomas with (immuno)-chemotherapy (ICT).
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PMC11604015
In a clinical trial (ChiCTR1900025311), 11 of 12 patients with R/R T-ALL or T-LBL achieved CR after GC027 infusion.
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PMC11786767
After removing nocodazole, the cells were allowed to recover for 15, 30, or 60 min before being harvested for immunostaining.
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PMC11591052
Likewise, the role of AP-1 in skeletal muscle metabolism is still enigmatic; however, it was reported to act together with the Estrogen Related Receptor to activate transcription of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) .
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PMC5673060
Although our laboratory was able to identify common molecular alterations in PDGFRα and FGFR1 in the dasatinib- and pazopanib-resistant A204 cell lines, gene expression and copy number analyses of these cells have revealed clear differences between their molecular profiles .
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PMC11730311
A γGlu linker was incorporated between the peptide and the connected C18DA or C20DA.
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PMC11055323
SS, SS18-SSX1.
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PMC10502403
The error bar shows the standard deviation.
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PMC11706491
CDK activity is minimal during the G1 phase but increases in a stepwise manner as the cell progresses through the cycle, with distinct thresholds at the G1/S and G2/M transitions, reaching peak activity at metaphase .
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PMC9424261
Murine double minute 2 (MDM2), or HDM2 in humans, is an oncoprotein [36–38].
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PMC9429973
Image: Summary/Conclusion: In this cohort of pts with DBA, molecular diagnosis was achieved in the majority.
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PMC11474209
Due to the extensive use of freshwater systems, the nutrient load increases, leading to frequent cyanobacterial blooms.
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PMC8806312
The nomogram for predicting overall survival A nomogram was established using the independent significant prognostic factors, which contain metastasis and risk score for predicting survival probability for twelve, twenty-four, and forty-eight months.
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PMC9429973
Results: CRE-carriers were identified in 59/2465 (2.39%) patients and19/59 (32.2%) developed CRE-BSI, while 12/2406 (0.5%) of non-carriers developed CRE-BSI (P<0.001).
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PMC11092418
Following a 4-h incubation, “time zero” plate (representing the initial number of cells prior to treatment) was fixed with 10% trichloroacetic acid (Fisher Scientific, Loughborough, UK) for 1 h at room temperature, washed thrice with tap water and left to air dry overnight.
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PMC9812014
An experiment on ZIKVR2A which has the Renilla luciferase reporter gene showed that Cherylline at EC50 of 20.3 μM inhibited the ZIKVR2A replication with a selectivity index of > 12.3.
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PMC11769516
In recent years, the European Food Safety Authority (EFSA) has defined the tolerable daily intake of the sum of T-2 trichothecene mycotoxins produced by Fusarium spp.
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PMC9429973
Suge had a well-tolerated safety profile and no new safety signals were detected.
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PMC10317042
First, we investigated SOX10 protein expression during vorinostat treatment, finding a dose-dependent reduction in this expression (Fig. 5A).
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PMC11095939
Figure 6—figure supplement 1.Related to Figure 6.(A) Schematic showing the definition of Mecp2-binding genes.
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PMC9019892
These results support the notion that the application of nintedanib may be a new strategy for enhancing the treatment for GIST patients with de novo or acquired resistance to imatinib.
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PMC5311252
fully tryptic peptides, maximum peptide length of 50 amino acids and a maximum charge of 6.
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PMC11489275
Fig. 1Correlation between changes of lymphocytes and risk of death within the short-term.
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PMC11701801
When the cBAF and/or ncBAF complex containing SS18-WT is localized to the transcriptional regulatory region of the KREMEN2 locus, it represses transcription of KREMEN2.
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PMC11612626
The supernatant containing lentiviral particles was collected 53 hours post-transfection, filtered through a 0.45-μm PES filter.
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PMC11473843
Notably, TRRUST (Han et al, 2018) analysis revealed that the cluster 5 was enriched in targets of many transcription factors that, according to STRING database (https://string-db.org), had been previously shown to interact in multiprotein complexes.
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PMC7452526
Recently scientists and researchers are working to discover new treatments for cancer-based on the use of new-featured materials.
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PMC7338939
Unlike A375 cells, NA8 cells (malignant cells) showed an increase in cell division, in all doses and times after DAPT treatment (Figure 1K, P < 0.05).
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PMC9599726
Transmitted light illumination was provided by a HAL100 halogen lamp and condenser in “bright-field position”.
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PMC11013014
Thus, the development of new cancer therapies with more specificity and selectivity is very requested .
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PMC10452486
As a result, NK cells in the endometrial decidual tissue, both KIR2DL1/2, as well as monomeric, homo- and heterodimeric variants of B2m-free HLA-F, HLA-C, and other HLA-I are activated for functional interactions .
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PMC11774747
Many off-the-shelf products, such as UCART19/ALLO-501, have shown encouraging outcomes, achieving a 48% overall response rate (ORR) in B-ALL and lymphoma with manageable GvHD (45).
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PMC10719213
The precise mode of action arising from therapeutic cladribine administration is not fully understood in MS, as the temporal kinetics of depletion are protracted with effects on both resting and dividing cells .
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PMC6835428
To improve their stability and thus effectiveness, it is possible to chemically modify their structure to make them more resistant to degradation .
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PMC11708541
Munir et al., examined how 2-AP compounds bind when used as JAK2 inhibitors.
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PMC11754784
As shown in Fig. 6a and Supplementary Fig. 33, the mixed cells incubated with Nb-S showed obvious FITC fluorescence, indicating that the indiscriminate binding of CEM and erythrocytes.
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PMC10178190
In this study, we focused on secreted soluble factors and tested their ability to confer chemoresistance.
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PMC11629192
About 10 %–30 % of pediatric anti-NMDAR encephalitis patients need second-line immunotherapy with RTX prefer to be used [, , , ].
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PMC8193046
no inhibition; apparent ABCC1 activation (effect at 10 µM: 12.7% ± 2.4%). (
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PMC11703992
Specifically, to explore the difference of metabolic flux between the CD4+ Memory T cell subtypes, we performed single cell flux estimation analysis (scFEA, ver 1.1.2) .
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PMC9429973
The preliminary results from knockdown of LILRA4 indicated a potential immunomodulating role of LILRA4 through interaction with MIF, although the specific biological function of this gene in this setting remains to be elucidated.
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PMC10376064
Concentrations higher than 30 µM could not be applied due to the occurring toxicity of DMF against H69AR cells.
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PMC7802142
The sequences were as follows: 5′-CACAAGUUCGGAUCUACGGGUU-3′ for anti-miR-100, 5′-CAGUACUUUUGUGUAGUACAA-3′ for anti-NC.
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PMC11788920
Due to small level of inhibition in cell viability in the TR-only (in the absence CRISPR–dCas9 targeting) and RNP1 cases, the data could not be fitted reliably. (
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PMC11528603
These are distinct morphological features of apoptotic cells.
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PMC10988555
Nonetheless, a similar pattern upon coordination as in the H NMR spectra was observed.
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PMC6450504
Even with this shift in ZP, the interaction with all cell lines was augmented after liposomes were coated with bPEI (Figure 2(a–c)).
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PMC5854676
Therefore, the introduction of inorganic nanomaterial oxide antimicrobial agents can improve neural functioning through advanced therapeutic modification.
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PMC11401350
Making use of the distinct surface markers of T-cell subtypes, CD8 for cytotoxic T lymphocytes and CD4 for helper and regulatory T cells, enabled the generation of LVs targeted to specific T-cell subtypes .
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PMC9429973
Single-cell RNA sequencing of drug-treated co-cultures revealed the transcriptomic phenotypes of NK cell and target cells under SMAC mimetic treatment.
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PMC11040965
This HLA-A*0201-restricted peptide is derived from cancer/testis antigen 1B (alias NY-ESO-1), which is highly expressed by U266 cells .
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PMC10956161
It appears to be associated with a poor prognosis in patients with lung adenocarcinoma, which might provide a new target for clinical treatment.
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PMC11772449
Due to the low detection rate of liver cancer in the curable stage and the high recurrence rate, the prognosis is poor (Liu et al., 2017).
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PMC11705484
Two‐tailed Student's t‐test was used for comparisons between the two groups.
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PMC7762347
The expression of studied genes was determined by qPCR after 72 h treatment of HepG2 cells to cyanotoxins and their combination as explained in Section 5.3.
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PMC8358006
Adapter-trimmed reads were mapped to the human genome version hg38 using Bismark v0.20.1 with default parameter values.
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PMC11754436
mm represent miR-362-5p mimic group.
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PMC11206502
Autophagy is a dynamic and complex process that is regulated by multiple molecules and has a contradictory role in tumor metabolism.
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PMC11767817
These findings are consistent with the LDH release assay (Figure 3), which showed increased LDH levels after 24 h of treatment with compound 2a-B. Together, these results highlight the dual apoptotic and necrotic/late apoptotic effects of compound 2a-B, particularly during the extended incubation period.
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PMC11764090
MYC2 is a core transcription factor for JA signaling and a hub between ABA, SA, GAs, and IAA signaling .
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PMC6889484
Thumbi Ndung’u, Boris Renjifo, and Max Essex; catalog #6439).
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PMC11610461
Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils to trap microorganisms and their main function is antimicrobial defense (Van Avondt & Hartl, 2018).
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PMC9429973
However, there is scarce data regarding the diversity of peptide-binding pockets per se especially in the context of umbilical cord blood transplantation (UCBT).
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PMC11617590
Relative intensities were divided by the dentition of the β‐Actin bands.
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PMC11700247
B-C) AH1-specific T-cell infiltration in irradiated and abscopal tumors on day 23 and day 34 after tumor challenge. (
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PMC11026382
The values for TYMS R166Q, Q33S and WT are marked with red, cyan and black circles respectively.
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PMC10919056
Rapamycin. (
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PMC11127909
Additionally, 143BR-shEFHD1 cells showed higher degrees of mPTP opening and dramatically increased mPTP opening after cisplatin treatment (Fig. 4E).
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PMC11574271
The overexpression of RON can lead to its activation through spontaneous phosphorylation, initiating downstream activation of the JNK signaling pathway, which in turn inhibits HIF-2α ubiquitination and stabilizes its expression.
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PMC10589262
Mutant KIT (MT-KIT) was previously reported to be aberrantly localized in the Golgi complex and to exhibit sustained activation .
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PMC9919300
Notably, the treatment with andrographolide was able to revert the toxicity induced by the steatogenic medium, increasing the cell viability in respect to the steatogenic control and this effect was maintained after the treatment with the association.
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PMC11740207
Notably, MIAMICs can survive in challenging environments, including hypoxia, indicating a resilience not commonly seen in other adult SCs.
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PMC10747160
Furthermore, neither pre-incubation of Griffithsin with DC-SIGN-expressing cells nor pre-incubation of Griffithsin with SARS-CoV-2 pseudovirus led to a significant difference in viral infectivity.
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PMC9429973
Further prospective studies and homogeneous populations are needed to confirm these data.
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PMC11411004
Cells harvested on day 7 were used in the analysis.
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PMC9429973
Management was carried out by modified FAB LMB 96 protocols; 7 patients were not eligible for outcome analysis.
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PMC11679033
Most of the observed outcomes of CBMN Cyt Assay could be related aneuploidic effects of CIT.
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PMC11629143
To investigate whether p300 recruitment to CMV promoters impacts transgene expression, mAb mRNA transcripts were quantified by RT‐qPCR in CHO‐K1 cells stably expressing dCas9 or dCas9‐p300.
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PMC11756514
WTA is comprised of repeating units of ribitol phosphate modified by D-alanine and either α-1,4-GlcNAc, β-1,4-GlcNAc, or β-1,3-GlcNAc, which are added to the backbone by the glycosyltransferases TarM, TarS or TarP, respectively.
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PMC11590870
Higher amounts (650 µg/mL) were required for walnut hydrolysates to exert a similar antiproliferative effect on Caco-2 .
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PMC9545714
Low TEWL‐Placebo (N = 15, One subject missed the 8‐ and 16‐week clinic visits.
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PMC11583010
Otherwise, PDX fragments (2–3 mm.
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PMC11640555
Similarly, other NFs such as GDNF promote their growth when released by tumor cells .
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PMC10123657
Some mechanisms of intercellular communication involve the transfer of proteins, vesicles, and organelles, which contributes to drug and stress resistance of leukemic cells .
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PMC11449273
p < 0.05, **p < 0.01.
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PMC9813422
The KSHV genome is a linear double-stranded DNA.
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PMC10380508
On the other hand, PAX2 expression was found to be significantly reduced in high-grade RCC, particularly in the KIRC subtype, compared to low-grade RCC.
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PMC9429973
Aims: This study aims to identify the incidence of renal failure (RF) in NDMM and analyze the renal response (RR), hematological response (HR), the overall survival (OS) and the prognostic impact after induction therapy.
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PMC6461034
Vortex for 30–60 s at room temperature and at maximum speed until all tissue has been solubilized.
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PMC11555465
However, it is not known whether T. gondii and its secretions can inhibit the growth of bladder cancer.
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