OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10852540	Bcl-2 inhibits apoptosis, and Bcl-2 protein family has two types according to its function28.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bcl-2", "inhibits", "apoptosis", ",", "and", "Bcl-2", "protein", "family", "has", "two", "types", "according", "to", "its", "function28", "." ] } ]
PMC11762280	Statistical analysis of epidermal thickness and average optical densities of TUNEL, MPO, MMP9, F4/80 positive staining were shown (n = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "of", "epidermal", "thickness", "and", "average", "optical", "densities", "of", "TUNEL", ",", "MPO", ",", "MMP9", ",", "F4/80", "positive", "staining", "were", "shown", "(", "n", "=", "5", ")", "." ] } ]
PMC10547921	MMAE comprises four amino acids: monomethylvaline (MeVal), valine (Val), dolaisoleuine (Dil) and dolaproine (Dap), and the carboxy-terminal amine norephedrine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MMAE", "comprises", "four", "amino", "acids", ":", "monomethylvaline", "(", "MeVal", ")", ",", "valine", "(", "Val", ")", ",", "dolaisoleuine", "(", "Dil", ")", "and", "dolaproine", "(", "Dap", ")", ",", "and", "the", "carboxy-terminal", "amine", "norephedrine", "." ] } ]
PMC11011837	In fact, both Molt-16 and Molt-4 demonstrate higher levels of PC and PE in comparison to the Jurkat and CCRF-CEM cell lines.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "both", "Molt-16", "and", "Molt-4", "demonstrate", "higher", "levels", "of", "PC", "and", "PE", "in", "comparison", "to", "the", "Jurkat", "and", "CCRF-CEM", "cell", "lines", "." ] } ]
PMC11640247	However, this variant showed minimal effects on SRF-, NFκB-, and AP1-mediated gene expression pathways, which are downstream of Rho family proteins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "this", "variant", "showed", "minimal", "effects", "on", "SRF-", ",", "NFκB-", ",", "and", "AP1-mediated", "gene", "expression", "pathways", ",", "which", "are", "downstream", "of", "Rho", "family", "proteins", "." ] } ]
PMC11317131	Additional primers were generated to amplify successful insertion at ROSA26.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "primers", "were", "generated", "to", "amplify", "successful", "insertion", "at", "ROSA26", "." ] } ]
PMC9429973	One patient had delayed grade 4 leucoencephalopathy (MRI/brain biopsy were more indicative of fludarabine toxicity than CAR T related) and has ongoing neurological recovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "had", "delayed", "grade", "4", "leucoencephalopathy", "(", "MRI/brain", "biopsy", "were", "more", "indicative", "of", "fludarabine", "toxicity", "than", "CAR", "T", "related", ")", "and", "has", "ongoing", "neurological", "recovery", "." ] } ]
PMC9429973	Image: Summary/Conclusion: A novel scoring system—the TM frailty score—was developed by combining the TUG (T) and MNA-SF (M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "A", "novel", "scoring", "system", "—", "the", "TM", "frailty", "score", "—", "was", "developed", "by", "combining", "the", "TUG", "(", "T", ")", "and", "MNA-SF", "(", "M", ")", "." ] } ]
PMC11566417	Different letters on graphs indicate statistically significant differences between groups Mammosphere derived epithelial cell (MDEC) culture growth kinetics and cell composition are variably affected by immortalization and passage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "letters", "on", "graphs", "indicate", "statistically", "significant", "differences", "between", "groups", "Mammosphere", "derived", "epithelial", "cell", "(", "MDEC", ")", "culture", "growth", "kinetics", "and", "cell", "composition", "are", "variably", "affected", "by", "immortalization", "and", "passage", "." ] } ]
PMC11307990	All oligonucleotides were purchased from Sangon Biotech (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "oligonucleotides", "were", "purchased", "from", "Sangon", "Biotech", "(", "Shanghai", ",", "China", ")", "." ] } ]
PMC9429973	Aims: Therefore, we aimed to assess the predicting power of different RAMs for TE development, coupled with diagnostic algorithms that distinguish the objective need for radiological diagnostic procedures (colour duplex scan (CDS) and computerized tomography pulmonary angiography (CTPA)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Therefore", ",", "we", "aimed", "to", "assess", "the", "predicting", "power", "of", "different", "RAMs", "for", "TE", "development", ",", "coupled", "with", "diagnostic", "algorithms", "that", "distinguish", "the", "objective", "need", "for", "radiological", "diagnostic", "procedures", "(", "colour", "duplex", "scan", "(", "CDS", ")", "and", "computerized", "tomography", "pulmonary", "angiography", "(", "CTPA", ")", ")", "." ] } ]
PMC9874064	Finally, the therapeutic effect of NP-Pt-USP1i was further verified by H&E and TUNEL staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "therapeutic", "effect", "of", "NP-Pt-USP1i", "was", "further", "verified", "by", "H&E", "and", "TUNEL", "staining", "." ] } ]
PMC11656657	These findings indicate that the level of GD2 expression is critical for the efficacy of CAR.GD2 T-cell therapy in sarcomas, highlighting the need for accurate assessment of GD2 levels in tumors before initiating CAR T-cell immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "indicate", "that", "the", "level", "of", "GD2", "expression", "is", "critical", "for", "the", "efficacy", "of", "CAR.GD2", "T-cell", "therapy", "in", "sarcomas", ",", "highlighting", "the", "need", "for", "accurate", "assessment", "of", "GD2", "levels", "in", "tumors", "before", "initiating", "CAR", "T-cell", "immunotherapy", "." ] } ]
PMC6160470	Cellular signalling proteins affected by crown ethers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cellular", "signalling", "proteins", "affected", "by", "crown", "ethers", "." ] } ]
PMC8978939	In the past years, research has demonstrated that the SUMOylation of pVHL by the protein RSUME prevents the formation of the VBC complex, thus HIF-α is not degraded even under normal oxygen conditions (15, 16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "past", "years", ",", "research", "has", "demonstrated", "that", "the", "SUMOylation", "of", "pVHL", "by", "the", "protein", "RSUME", "prevents", "the", "formation", "of", "the", "VBC", "complex", ",", "thus", "HIF-α", "is", "not", "degraded", "even", "under", "normal", "oxygen", "conditions", "(", "15", ",", "16", ")", "." ] } ]
PMC5925824	n = 8 for all groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "8", "for", "all", "groups", "." ] } ]
PMC11718274	The effect of Y2O3NPs on ROS generation in cancerous A-431 cells was investigated using the 2,7-dichlorofluorescin diacetate (DCFH-DA) dye.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "Y2O3NPs", "on", "ROS", "generation", "in", "cancerous", "A-431", "cells", "was", "investigated", "using", "the", "2,7-dichlorofluorescin", "diacetate", "(", "DCFH-DA", ")", "dye", "." ] } ]
PMC9429973	Methods: We examined the bone marrow cells of 268 newly diagnosed AML patients using conventional karyotyping in combination with FISH (Abbott, MetaSystems) and mFISH/mBAND (MetaSystems).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "examined", "the", "bone", "marrow", "cells", "of", "268", "newly", "diagnosed", "AML", "patients", "using", "conventional", "karyotyping", "in", "combination", "with", "FISH", "(", "Abbott", ",", "MetaSystems", ")", "and", "mFISH/mBAND", "(", "MetaSystems", ")", "." ] } ]
PMC11697703	We carried out bioinformatic analyses to identify predicted targets of miRs-193b and 365 using miRanda, Targetscan, DIANALAB, and miRDB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "carried", "out", "bioinformatic", "analyses", "to", "identify", "predicted", "targets", "of", "miRs-193b", "and", "365", "using", "miRanda", ",", "Targetscan", ",", "DIANALAB", ",", "and", "miRDB", "." ] } ]
PMC10376064	The present study addresses two important aspects of the potential use of DMF as a repurposed anti-AD drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "present", "study", "addresses", "two", "important", "aspects", "of", "the", "potential", "use", "of", "DMF", "as", "a", "repurposed", "anti-AD", "drug", "." ] } ]
PMC9429973	As the pathophysiology of ABC-DLBCL involves a chronically active B-cell antigen receptor pathway, it was hypothesised that higher-risk ABC-subtype population may benefit from a Bruton’s tyrosine kinase inhibitor, such as ibrutinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "the", "pathophysiology", "of", "ABC-DLBCL", "involves", "a", "chronically", "active", "B-cell", "antigen", "receptor", "pathway", ",", "it", "was", "hypothesised", "that", "higher-risk", "ABC-subtype", "population", "may", "benefit", "from", "a", "Bruton", "’s", "tyrosine", "kinase", "inhibitor", ",", "such", "as", "ibrutinib", "." ] } ]
PMC8592717	PCA pre-administration suppressed the cadmium chloride (CdCl2)-induced apoptotic events through inhibition of mitochondria-caspase signaling pathway and mitigated Cd-induced neurotoxicity by activating Na+/K+-ATPase, butyrylcholinesterase, acetylcholinesterase, and antioxidant enzymes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "pre-administration", "suppressed", "the", "cadmium", "chloride", "(CdCl2)-induced", "apoptotic", "events", "through", "inhibition", "of", "mitochondria-caspase", "signaling", "pathway", "and", "mitigated", "Cd-induced", "neurotoxicity", "by", "activating", "Na+/K+-ATPase", ",", "butyrylcholinesterase", ",", "acetylcholinesterase", ",", "and", "antioxidant", "enzymes", "." ] } ]
PMC11122631	Nine fractions (A–I) were collected by eluting with hexanes/EtOAc/MeOH (8/1/0 to 0/0/1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nine", "fractions", "(", "A", "–", "I", ")", "were", "collected", "by", "eluting", "with", "hexanes/EtOAc/MeOH", "(", "8/1/0", "to", "0/0/1", ")", "." ] } ]
PMC11730311	CHO-K1 cells stably expressing the human calcitonin gene-related peptide receptor (PerkinElmer #ES-420-C stable monoclonal hCGRP-R cell line) were thawed from frozen cell stocks immediately before assays.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHO-K1", "cells", "stably", "expressing", "the", "human", "calcitonin", "gene-related", "peptide", "receptor", "(", "PerkinElmer", "#", "ES-420-C", "stable", "monoclonal", "hCGRP-R", "cell", "line", ")", "were", "thawed", "from", "frozen", "cell", "stocks", "immediately", "before", "assays", "." ] } ]
PMC11741906	A lot of research has employed experimental models particularly A2780, A2780DDP, and SKOV3 to investigate the impact of specific miRNAs on cisplatin treatment response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "lot", "of", "research", "has", "employed", "experimental", "models", "particularly", "A2780", ",", "A2780DDP", ",", "and", "SKOV3", "to", "investigate", "the", "impact", "of", "specific", "miRNAs", "on", "cisplatin", "treatment", "response", "." ] } ]
PMC11806182	The robustness of these results was further confirmed through sensitivity analyses (Fig. 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "robustness", "of", "these", "results", "was", "further", "confirmed", "through", "sensitivity", "analyses", "(", "Fig.", "6C", ")", "." ] } ]
PMC11381192	Circos plot representing the significant Spearman correlations across five cell stress indexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Circos", "plot", "representing", "the", "significant", "Spearman", "correlations", "across", "five", "cell", "stress", "indexes", "." ] } ]
PMC11471157	Its efficacy was then evaluated as a microcarrier in spheroid cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "efficacy", "was", "then", "evaluated", "as", "a", "microcarrier", "in", "spheroid", "cultures", "." ] } ]
PMC7582629	All-Trans-Retinoic Acid (ATRA) was used as control drug and it is generally used for acute promyelocytic leukemia treatment where the drug is unable to induce B-ALL regression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All-Trans-Retinoic", "Acid", "(", "ATRA", ")", "was", "used", "as", "control", "drug", "and", "it", "is", "generally", "used", "for", "acute", "promyelocytic", "leukemia", "treatment", "where", "the", "drug", "is", "unable", "to", "induce", "B-ALL", "regression", "." ] } ]
PMC11021472	CircRNAs can encompass single or multiple exons, with or without the presence of (part of) introns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CircRNAs", "can", "encompass", "single", "or", "multiple", "exons", ",", "with", "or", "without", "the", "presence", "of", "(", "part", "of", ")", "introns", "." ] } ]
PMC11012012	By flow cytometry, SLAMF5/CD84 cell surface levels were significantly higher in all CLL cells when compared with total or CD5+ normal B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "flow", "cytometry", ",", "SLAMF5/CD84", "cell", "surface", "levels", "were", "significantly", "higher", "in", "all", "CLL", "cells", "when", "compared", "with", "total", "or", "CD5", "+", "normal", "B", "cells", "." ] } ]
PMC11449273	p53 stability and function are regulated by various post-translational modifications such as phosphorylation, acetylation, sumoylation, methylation, and interactions with other proteins including plakoglobin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p53", "stability", "and", "function", "are", "regulated", "by", "various", "post-translational", "modifications", "such", "as", "phosphorylation", ",", "acetylation", ",", "sumoylation", ",", "methylation", ",", "and", "interactions", "with", "other", "proteins", "including", "plakoglobin", "." ] } ]
PMC10158546	Cells were then blocked with 10% goat serum+1% BSA in PBST for 1 h at room temp before incubating with primary antibodies in blocking buffer overnight at 4°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "blocked", "with", "10", "%", "goat", "serum+1", "%", "BSA", "in", "PBST", "for", "1", "h", "at", "room", "temp", "before", "incubating", "with", "primary", "antibodies", "in", "blocking", "buffer", "overnight", "at", "4", "°", "C", "." ] } ]
PMC11468365	As mentioned before, the MultiComb model is an end-to-end MTDL model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "mentioned", "before", ",", "the", "MultiComb", "model", "is", "an", "end-to-end", "MTDL", "model", "." ] } ]
PMC9780037	To ensure their specific targeting to cancer cells, some of these pocket structures were modified on their surface with ligands that bind specific molecules on the surface of cancer cells, triggering their endocytosis (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "ensure", "their", "specific", "targeting", "to", "cancer", "cells", ",", "some", "of", "these", "pocket", "structures", "were", "modified", "on", "their", "surface", "with", "ligands", "that", "bind", "specific", "molecules", "on", "the", "surface", "of", "cancer", "cells", ",", "triggering", "their", "endocytosis", "(", "Table", "3", ")", "." ] } ]
PMC11763764	Cell cycle phase distributions were analyzed with Flow-Jo v. 8.7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cycle", "phase", "distributions", "were", "analyzed", "with", "Flow-Jo", "v.", "8.7", "." ] } ]
PMC9429973	2.	[ { "tags": [ "O", "O" ], "tokens": [ "2", "." ] } ]
PMC2118063	Values in B and C indicate SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "in", "B", "and", "C", "indicate", "SD", "." ] } ]
PMC10729469	Following starvation, cells were incubated with a previously optimized non-toxic concentration, 1 mCi/mL F-FDG, for 1 h at 37 °C to allow uptake of radioactive glucose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "starvation", ",", "cells", "were", "incubated", "with", "a", "previously", "optimized", "non-toxic", "concentration", ",", "1", "mCi/mL", "F-FDG", ",", "for", "1", "h", "at", "37", "°", "C", "to", "allow", "uptake", "of", "radioactive", "glucose", "." ] } ]
PMC4395774	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC9429973	On the contrary, select patients with FLC ratio ≥100 can be followed for many years without progressing and some may never progress despite long-term follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "contrary", ",", "select", "patients", "with", "FLC", "ratio", "≥100", "can", "be", "followed", "for", "many", "years", "without", "progressing", "and", "some", "may", "never", "progress", "despite", "long-term", "follow-up", "." ] } ]
PMC11640247	RAC1 is ubiquitously expressed, while RAC2 is mainly found in hematopoietic cells, and RAC3 is predominantly expressed in the brain .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RAC1", "is", "ubiquitously", "expressed", ",", "while", "RAC2", "is", "mainly", "found", "in", "hematopoietic", "cells", ",", "and", "RAC3", "is", "predominantly", "expressed", "in", "the", "brain", "." ] } ]
PMC11757230	After 72 h, the floating LL cells were separated from the cADSCs by gentle pipetting or by removing the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "72", "h", ",", "the", "floating", "LL", "cells", "were", "separated", "from", "the", "cADSCs", "by", "gentle", "pipetting", "or", "by", "removing", "the", "membrane", "." ] } ]
PMC11673902	This exchange is manifested macroscopically as the sound wave exerts a force on the object, called the acoustic radiant force (ARF) (Figure 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "exchange", "is", "manifested", "macroscopically", "as", "the", "sound", "wave", "exerts", "a", "force", "on", "the", "object", ",", "called", "the", "acoustic", "radiant", "force", "(", "ARF", ")", "(", "Figure", "7", ")", "." ] } ]
PMC11607638	The wild‐type A. aegypti Rockefeller strain was reared at 24–27°C with 70% relative humidity in The Insectary at Hainan University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "wild‐type", "A.", "aegypti", "Rockefeller", "strain", "was", "reared", "at", "24–27", "°", "C", "with", "70", "%", "relative", "humidity", "in", "The", "Insectary", "at", "Hainan", "University", "." ] } ]
PMC7802142	Stem cell-derived EVs are believed to inherit the growth-promoting properties of stem cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stem", "cell-derived", "EVs", "are", "believed", "to", "inherit", "the", "growth-promoting", "properties", "of", "stem", "cells", "." ] } ]
PMC11806182	These experimental data suggest that these drugs could modulate critical biological pathways in UCEC, potentially impacting disease progression and providing insights into therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "experimental", "data", "suggest", "that", "these", "drugs", "could", "modulate", "critical", "biological", "pathways", "in", "UCEC", ",", "potentially", "impacting", "disease", "progression", "and", "providing", "insights", "into", "therapeutic", "strategies", "." ] } ]
PMC11400680	Figure 8 depicts bar plots illustrating the counts of cells and nuclei segmented by our proposed method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "8", "depicts", "bar", "plots", "illustrating", "the", "counts", "of", "cells", "and", "nuclei", "segmented", "by", "our", "proposed", "method", "." ] } ]
PMC10656496	This differential response to glutamine stood out as a selection pressure parameter to explore further.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "differential", "response", "to", "glutamine", "stood", "out", "as", "a", "selection", "pressure", "parameter", "to", "explore", "further", "." ] } ]
PMC10758402	The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "raw", "data", "supporting", "the", "conclusions", "of", "this", "article", "will", "be", "made", "available", "by", "the", "authors", ",", "without", "undue", "reservation", "." ] } ]
PMC10440586	To further explore the impact of CD99 expression on ICB therapy, we analyzed a cohort including primary and secondary surgery samples from 27 patients with recurrent glioma who received neoadjuvant nivolumab therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "explore", "the", "impact", "of", "CD99", "expression", "on", "ICB", "therapy", ",", "we", "analyzed", "a", "cohort", "including", "primary", "and", "secondary", "surgery", "samples", "from", "27", "patients", "with", "recurrent", "glioma", "who", "received", "neoadjuvant", "nivolumab", "therapy", "." ] } ]
PMC4695073	Cisplatin and other platinum-based antitumor drugs have been exerted on a wide range of tumors including testicular, head and neck, lung, ovarian, bladder cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "and", "other", "platinum-based", "antitumor", "drugs", "have", "been", "exerted", "on", "a", "wide", "range", "of", "tumors", "including", "testicular", ",", "head", "and", "neck", ",", "lung", ",", "ovarian", ",", "bladder", "cancers", "." ] } ]
PMC11377827	Control vs. USP43 sgRNA +Rox *P = 0.0269.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "vs.", "USP43", "sgRNA", "+", "Rox", "*", "P", "=", "0.0269", "." ] } ]
PMC5874706	The in vitro release experiments were performed in order to confirm what has previously been observed in similar systems: the benefit of nanoparticle encapsulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "in", "vitro", "release", "experiments", "were", "performed", "in", "order", "to", "confirm", "what", "has", "previously", "been", "observed", "in", "similar", "systems", ":", "the", "benefit", "of", "nanoparticle", "encapsulation", "." ] } ]
PMC11792888	Representative histograms of the cell cycle in the CHO-K1 cell line, after scorpion venom treatment for 48 h. Bar graph summary representing the percentage of cells in G0/G1, S, and G2/M in CHO-K1cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Representative", "histograms", "of", "the", "cell", "cycle", "in", "the", "CHO-K1", "cell", "line", ",", "after", "scorpion", "venom", "treatment", "for", "48", "h.", "Bar", "graph", "summary", "representing", "the", "percentage", "of", "cells", "in", "G0/G1", ",", "S", ",", "and", "G2/M", "in", "CHO-K1cells", ".", "(" ] } ]
PMC11225860	Two mice in the Aurkin A and one mouse in the Alisertib treatment groups did not exhibit tumor growth post cell injection and were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "mice", "in", "the", "Aurkin", "A", "and", "one", "mouse", "in", "the", "Alisertib", "treatment", "groups", "did", "not", "exhibit", "tumor", "growth", "post", "cell", "injection", "and", "were", "excluded", "." ] } ]
PMC11477621	Subsequently, a pharmacokinetic study of compound 20 was conducted in male ICR mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "a", "pharmacokinetic", "study", "of", "compound", "20", "was", "conducted", "in", "male", "ICR", "mice", "." ] } ]
PMC11761919	The release of bacteria from the microcapsules was completed within 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "release", "of", "bacteria", "from", "the", "microcapsules", "was", "completed", "within", "30", "min", "." ] } ]
PMC11650848	It would be of value to identify if these CTCF sites have insulator effects or form loops for regulation of genes in different loci.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "would", "be", "of", "value", "to", "identify", "if", "these", "CTCF", "sites", "have", "insulator", "effects", "or", "form", "loops", "for", "regulation", "of", "genes", "in", "different", "loci", "." ] } ]
PMC9592219	The proteins in the gels were translocated in polyvinylidene difluoride membranes after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proteins", "in", "the", "gels", "were", "translocated", "in", "polyvinylidene", "difluoride", "membranes", "after", "separation", "by", "sodium", "dodecyl", "sulfate-polyacrylamide", "gel", "electrophoresis", "." ] } ]
PMC11257203	Part of this effect might be through modulating oxidative stress markers, such as a reduction in MDA level and an increment in the level of GSH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Part", "of", "this", "effect", "might", "be", "through", "modulating", "oxidative", "stress", "markers", ",", "such", "as", "a", "reduction", "in", "MDA", "level", "and", "an", "increment", "in", "the", "level", "of", "GSH", "." ] } ]
PMC9429973	Further studies with larger sample size and longer follow-up are required to confirm our conclusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "with", "larger", "sample", "size", "and", "longer", "follow-up", "are", "required", "to", "confirm", "our", "conclusion", "." ] } ]
PMC11730320	In addition, γδ T cells have lower TCR repertoire diversity than αβ, are found predominantly within epithelial and mucosal tissue, and are thus considered to play an intermediate role between innate and adaptive immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "γδ", "T", "cells", "have", "lower", "TCR", "repertoire", "diversity", "than", "αβ", ",", "are", "found", "predominantly", "within", "epithelial", "and", "mucosal", "tissue", ",", "and", "are", "thus", "considered", "to", "play", "an", "intermediate", "role", "between", "innate", "and", "adaptive", "immunity", "." ] } ]
PMC11585587	Notably, the IC50 values for MM.1 S cells were 1.616 µM at 24 H and 1.058 µM at 48 H, for MM.1R cells were 3.905 µM at 24 H and 2.18 µM at 48 H, while for RPMI 8226 cells, they were 6.091 µM at 24 H and 3.438 µM at 48 H (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "the", "IC50", "values", "for", "MM.1", "S", "cells", "were", "1.616", "µM", "at", "24", "H", "and", "1.058", "µM", "at", "48", "H", ",", "for", "MM.1R", "cells", "were", "3.905", "µM", "at", "24", "H", "and", "2.18", "µM", "at", "48", "H", ",", "while", "for", "RPMI", "8226", "cells", ",", "they", "were", "6.091", "µM", "at", "24", "H", "and", "3.438", "µM", "at", "48", "H", "(", "Fig.", "1", ")", "." ] } ]
PMC11683240	A–B, PT (100 ng/ml = 0.000952 μM) and different concentrations of α1AT or the respective amount of solvent (H2O) were added directly to CHO-K1 cells and incubated for 4 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "–", "B", ",", "PT", "(", "100", "ng/ml", "=", "0.000952", "μM", ")", "and", "different", "concentrations", "of", "α1AT", "or", "the", "respective", "amount", "of", "solvent", "(", "H2O", ")", "were", "added", "directly", "to", "CHO-K1", "cells", "and", "incubated", "for", "4", "h", "at", "37", "°", "C", "." ] } ]
PMC11411004	To identify useful small-molecule regulators that enhance the expression of recombinant proteins in Chinese hamster ovary (CHO) cells, we examined a novel dual-HDAC/LSD1 inhibitor I-4 as a supplement for recombinant CHO cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "identify", "useful", "small-molecule", "regulators", "that", "enhance", "the", "expression", "of", "recombinant", "proteins", "in", "Chinese", "hamster", "ovary", "(", "CHO", ")", "cells", ",", "we", "examined", "a", "novel", "dual-HDAC/LSD1", "inhibitor", "I-4", "as", "a", "supplement", "for", "recombinant", "CHO", "cells", "." ] } ]
PMC9429973	Twenty-five pts were on active treatment for IBD at the time of MN diagnosis (9 on biological agent, 11 on mesalamine, and 2 on azathioprine), whereas 18 were in remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-five", "pts", "were", "on", "active", "treatment", "for", "IBD", "at", "the", "time", "of", "MN", "diagnosis", "(", "9", "on", "biological", "agent", ",", "11", "on", "mesalamine", ",", "and", "2", "on", "azathioprine", ")", ",", "whereas", "18", "were", "in", "remission", "." ] } ]
PMC11307990	Results in the left were compared using one-way ANOVA, *** p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "in", "the", "left", "were", "compared", "using", "one-way", "ANOVA", ",", "", "", "*", "p", "<", "0.001", "." ] } ]
PMC11093197	Cells were washed with PBS and were fixed with 4% PFA at RT for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "washed", "with", "PBS", "and", "were", "fixed", "with", "4", "%", "PFA", "at", "RT", "for", "10", "min", "." ] } ]
PMC11354225	Cells were seeded in 24-well plates, at a total of 1 × 10 cells/well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", "in", "24-well", "plates", ",", "at", "a", "total", "of", "1", "×", "10", "cells/well", "." ] } ]
PMC10761571	Data are stated as mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "stated", "as", "mean", "±", "SD", "." ] } ]
PMC9386809	The resulting mixture was heated at 110 °C for 12 h. The reaction mixture was cooled to room temperature, and dry diisopropylethylamine (7 mg, 0.0546 mmol dissolved in 1 mL of dry toluene) was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "mixture", "was", "heated", "at", "110", "°", "C", "for", "12", "h.", "The", "reaction", "mixture", "was", "cooled", "to", "room", "temperature", ",", "and", "dry", "diisopropylethylamine", "(", "7", "mg", ",", "0.0546", "mmol", "dissolved", "in", "1", "mL", "of", "dry", "toluene", ")", "was", "added", "." ] } ]
PMC8623816	Here, we describe a novel double-stranded (ds) RNA mycovirus designated Rhizoctonia solani dsRNA virus 5 (RsRV5) from strain D122 of Rhizoctonia solani AG-1 IA, the causal agent of rice sheath blight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "describe", "a", "novel", "double-stranded", "(", "ds", ")", "RNA", "mycovirus", "designated", "Rhizoctonia", "solani", "dsRNA", "virus", "5", "(", "RsRV5", ")", "from", "strain", "D122", "of", "Rhizoctonia", "solani", "AG-1", "IA", ",", "the", "causal", "agent", "of", "rice", "sheath", "blight", "." ] } ]
PMC11476222	The ganglioside biosynthesis pathway and MS traces of the gangliosides identified in the cell lines are shown in Figure 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ganglioside", "biosynthesis", "pathway", "and", "MS", "traces", "of", "the", "gangliosides", "identified", "in", "the", "cell", "lines", "are", "shown", "in", "Figure", "5", "." ] } ]
PMC11552389	These findings suggest that FOXN3 may be an attractive therapeutic intervention target for overcoming melanoma tumor drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "FOXN3", "may", "be", "an", "attractive", "therapeutic", "intervention", "target", "for", "overcoming", "melanoma", "tumor", "drug", "resistance", "." ] } ]
PMC11788920	The symbols are data points and lines are Hill function fit to the respective data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "symbols", "are", "data", "points", "and", "lines", "are", "Hill", "function", "fit", "to", "the", "respective", "data", "." ] } ]
PMC9429973	The 6 cycles of ZR-CHOP plus 2R were administered as induction therapy, with no maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "6", "cycles", "of", "ZR-CHOP", "plus", "2R", "were", "administered", "as", "induction", "therapy", ",", "with", "no", "maintenance", "." ] } ]
PMC9812014	Oxoglyantrypine alkaloid derived from the marine mangrove plant-fungal strain Cladosporium sp. was noted to have a repressive effect against the IAV with an IC50 of 85 μM; other alkaloids derived from this fungal strain were Norquinadoline A, Deoxynortryptoquivaline, Deoxytryptoquivaline, Tryptoquivaline had also a reported inhibitory effect with an IC50 of 82, 87, 85, 89 μM, respectively, against IAV .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oxoglyantrypine", "alkaloid", "derived", "from", "the", "marine", "mangrove", "plant-fungal", "strain", "Cladosporium", "sp.", "was", "noted", "to", "have", "a", "repressive", "effect", "against", "the", "IAV", "with", "an", "IC50", "of", "85", "μM", ";", "other", "alkaloids", "derived", "from", "this", "fungal", "strain", "were", "Norquinadoline", "A", ",", "Deoxynortryptoquivaline", ",", "Deoxytryptoquivaline", ",", "Tryptoquivaline", "had", "also", "a", "reported", "inhibitory", "effect", "with", "an", "IC50", "of", "82", ",", "87", ",", "85", ",", "89", "μM", ",", "respectively", ",", "against", "IAV", "." ] } ]
PMC11541241	Host‐induced gene silencing (HIGS) is an RNA interference (RNAi)‐based natural method used by plant hosts to transfer small RNAs (sRNAs) to defend themselves against invaders (Baulcombe, 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Host‐induced", "gene", "silencing", "(", "HIGS", ")", "is", "an", "RNA", "interference", "(RNAi)‐based", "natural", "method", "used", "by", "plant", "hosts", "to", "transfer", "small", "RNAs", "(", "sRNAs", ")", "to", "defend", "themselves", "against", "invaders", "(", "Baulcombe", ",", "2015", ")", "." ] } ]
PMC10547921	Therefore, in order to further expand the range of ADC payloads and identify other types of ADC payloads that are effective in both fast and slow-proliferating cells and can escape MDR-mediated resistance, attention has turned to small molecular payloads targeting RNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "in", "order", "to", "further", "expand", "the", "range", "of", "ADC", "payloads", "and", "identify", "other", "types", "of", "ADC", "payloads", "that", "are", "effective", "in", "both", "fast", "and", "slow-proliferating", "cells", "and", "can", "escape", "MDR-mediated", "resistance", ",", "attention", "has", "turned", "to", "small", "molecular", "payloads", "targeting", "RNA", "." ] } ]
PMC8557138	Hydrogels, soft polymer materials containing 3D structural networks, are preferred for the construction of vascular tissues due to their ability to retain water in 3D networks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydrogels", ",", "soft", "polymer", "materials", "containing", "3D", "structural", "networks", ",", "are", "preferred", "for", "the", "construction", "of", "vascular", "tissues", "due", "to", "their", "ability", "to", "retain", "water", "in", "3D", "networks", "." ] } ]
PMC11673902	This technique not only improves the accuracy of single-cell analysis but also extends the range of applications of cell mechanics research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "technique", "not", "only", "improves", "the", "accuracy", "of", "single-cell", "analysis", "but", "also", "extends", "the", "range", "of", "applications", "of", "cell", "mechanics", "research", "." ] } ]
PMC11711871	Differences were assessed at P < 0.05 and ***P < 0.0001Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "were", "assessed", "at", "", "P", "<", "0.05", "and", "", "", "", "*", "P", "<", "0.0001Fig", "." ] } ]
PMC11703896	To address these challenges, future studies could explore receptor-specific analogs or targeted delivery systems, aiming to optimize rapamycin’s efficacy while minimizing risks to normal tissues (Figs. 4, 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "these", "challenges", ",", "future", "studies", "could", "explore", "receptor-specific", "analogs", "or", "targeted", "delivery", "systems", ",", "aiming", "to", "optimize", "rapamycin", "’s", "efficacy", "while", "minimizing", "risks", "to", "normal", "tissues", "(", "Figs.", "4", ",", "5", ")", "." ] } ]
PMC11747949	Our coculture system is considered indirect as it lacks cell‐to‐cell contact and relies on communication via secretory factors (Rasouli and Safari 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "coculture", "system", "is", "considered", "indirect", "as", "it", "lacks", "cell‐to‐cell", "contact", "and", "relies", "on", "communication", "via", "secretory", "factors", "(", "Rasouli", "and", "Safari", "2024", ")", "." ] } ]
PMC11209164	The extraction of total RNA from both infected and mock-infected 786-0 cells was conducted using the RNeasy Mini Kit, following the instructions provided by the manufacturer. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extraction", "of", "total", "RNA", "from", "both", "infected", "and", "mock-infected", "786", "-", "0", "cells", "was", "conducted", "using", "the", "RNeasy", "Mini", "Kit", ",", "following", "the", "instructions", "provided", "by", "the", "manufacturer", ".", "(" ] } ]
PMC10079526	In addition, our in vivo experiments showed no significant reduction in tumor outgrowth in response to SUMOylation inhibition as single compound therapy, whereas literature suggest that SUMO abolishment by genetic knock down of the E1 enzyme does reduce tumor outgrowth in MYC dependent tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "our", "in", "vivo", "experiments", "showed", "no", "significant", "reduction", "in", "tumor", "outgrowth", "in", "response", "to", "SUMOylation", "inhibition", "as", "single", "compound", "therapy", ",", "whereas", "literature", "suggest", "that", "SUMO", "abolishment", "by", "genetic", "knock", "down", "of", "the", "E1", "enzyme", "does", "reduce", "tumor", "outgrowth", "in", "MYC", "dependent", "tumors", "." ] } ]
PMC9429973	In both parts, median prior LOT was 5 (range 3–13); 10 pts (29%) had high-risk cytogenetics and 9 (26%) had extramedullary disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "both", "parts", ",", "median", "prior", "LOT", "was", "5", "(", "range", "3–13", ")", ";", "10", "pts", "(", "29", "%", ")", "had", "high-risk", "cytogenetics", "and", "9", "(", "26", "%", ")", "had", "extramedullary", "disease", "." ] } ]
PMC11638255	This phenomenon did not occur in untreated neuroblastoma cells, indicating that copper chelation therapy modulates levels of copper in the tumor microenvironment to facilitate copper uptake by neutrophils.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "phenomenon", "did", "not", "occur", "in", "untreated", "neuroblastoma", "cells", ",", "indicating", "that", "copper", "chelation", "therapy", "modulates", "levels", "of", "copper", "in", "the", "tumor", "microenvironment", "to", "facilitate", "copper", "uptake", "by", "neutrophils", "." ] } ]
PMC11650848	Several cognitive results were compared for correlations with the mQTL genotypes and their methylation patterns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "cognitive", "results", "were", "compared", "for", "correlations", "with", "the", "mQTL", "genotypes", "and", "their", "methylation", "patterns", "." ] } ]
PMC11725127	The precipitates pulled down by biotin–GA or biotin from MM.1S or RPMI 8226 cell lysates were examined by western blotting with anti-USP2 antibody. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "precipitates", "pulled", "down", "by", "biotin", "–", "GA", "or", "biotin", "from", "MM.1S", "or", "RPMI", "8226", "cell", "lysates", "were", "examined", "by", "western", "blotting", "with", "anti-USP2", "antibody", ".", "(" ] } ]
PMC8916024	In general, the bacterial diversity in the sediment samples was significantly higher than that in the snail guts (P < 0.001), and there was no significant difference in the diversity of the gut flora of adult and juvenile snails (P > 0.05), as assessed by the Sobs, Shannon, Chao, and ACE indices (Fig. 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "the", "bacterial", "diversity", "in", "the", "sediment", "samples", "was", "significantly", "higher", "than", "that", "in", "the", "snail", "guts", "(", "P", "<", "0.001", ")", ",", "and", "there", "was", "no", "significant", "difference", "in", "the", "diversity", "of", "the", "gut", "flora", "of", "adult", "and", "juvenile", "snails", "(", "P", ">", "0.05", ")", ",", "as", "assessed", "by", "the", "Sobs", ",", "Shannon", ",", "Chao", ",", "and", "ACE", "indices", "(", "Fig.", "1B", ")", "." ] } ]
PMC10887351	β2-ARs, which display a higher affinity for A, are localized in the liver, skeletal muscle and in gastrointestinal and bronchial smooth muscle cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β2-ARs", ",", "which", "display", "a", "higher", "affinity", "for", "A", ",", "are", "localized", "in", "the", "liver", ",", "skeletal", "muscle", "and", "in", "gastrointestinal", "and", "bronchial", "smooth", "muscle", "cells", "." ] } ]
PMC10198699	Now that it has been established that HBM in the research context is susceptible of ownership, that the transfer of ownership by the research participant to the research institution is peremptory, and that HBM and the information contained therein are not regulated by POPIA, I consider the three scenarios.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Now", "that", "it", "has", "been", "established", "that", "HBM", "in", "the", "research", "context", "is", "susceptible", "of", "ownership", ",", "that", "the", "transfer", "of", "ownership", "by", "the", "research", "participant", "to", "the", "research", "institution", "is", "peremptory", ",", "and", "that", "HBM", "and", "the", "information", "contained", "therein", "are", "not", "regulated", "by", "POPIA", ",", "I", "consider", "the", "three", "scenarios", "." ] } ]
PMC10907726	Fig. 3Fig.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Fig.", "3Fig", "." ] } ]
PMC11371747	Cell culture flasks were purchased from Greiner Bio one (Alphen aan de Rijn, Netherlands).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "culture", "flasks", "were", "purchased", "from", "Greiner", "Bio", "one", "(", "Alphen", "aan", "de", "Rijn", ",", "Netherlands", ")", "." ] } ]
PMC9739791	The first one is the photocatalytic strategy based on the flavin derivatives that are not covalently bound to the Pt(IV) substrate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "first", "one", "is", "the", "photocatalytic", "strategy", "based", "on", "the", "flavin", "derivatives", "that", "are", "not", "covalently", "bound", "to", "the", "Pt(IV", ")", "substrate", "." ] } ]
PMC11585994	The gel displays G5, sgc8, and siBCL11B, along with siBCL11B combined with sgc8 and G5. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gel", "displays", "G5", ",", "sgc8", ",", "and", "siBCL11B", ",", "along", "with", "siBCL11B", "combined", "with", "sgc8", "and", "G5", ".", "(" ] } ]
PMC11762280	Epidermal thickness was measured in three randomly selected fields of view of non-necrotic epidermis in H&E-stained sections, and the values were averaged to assess the degree of epidermal edema and hyperplasia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Epidermal", "thickness", "was", "measured", "in", "three", "randomly", "selected", "fields", "of", "view", "of", "non-necrotic", "epidermis", "in", "H&E-stained", "sections", ",", "and", "the", "values", "were", "averaged", "to", "assess", "the", "degree", "of", "epidermal", "edema", "and", "hyperplasia", "." ] } ]
PMC11588085	Altogether, our data suggest that XIST plays a crucial role in cellular plasticity and identity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Altogether", ",", "our", "data", "suggest", "that", "XIST", "plays", "a", "crucial", "role", "in", "cellular", "plasticity", "and", "identity", "." ] } ]

PMC10852540

Bcl-2 inhibits apoptosis, and Bcl-2 protein family has two types according to its function28.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bcl-2", "inhibits", "apoptosis", ",", "and", "Bcl-2", "protein", "family", "has", "two", "types", "according", "to", "its", "function28", "." ] } ]

PMC11762280

Statistical analysis of epidermal thickness and average optical densities of TUNEL, MPO, MMP9, F4/80 positive staining were shown (n = 5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "of", "epidermal", "thickness", "and", "average", "optical", "densities", "of", "TUNEL", ",", "MPO", ",", "MMP9", ",", "F4/80", "positive", "staining", "were", "shown", "(", "n", "=", "5", ")", "." ] } ]

PMC10547921

MMAE comprises four amino acids: monomethylvaline (MeVal), valine (Val), dolaisoleuine (Dil) and dolaproine (Dap), and the carboxy-terminal amine norephedrine.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MMAE", "comprises", "four", "amino", "acids", ":", "monomethylvaline", "(", "MeVal", ")", ",", "valine", "(", "Val", ")", ",", "dolaisoleuine", "(", "Dil", ")", "and", "dolaproine", "(", "Dap", ")", ",", "and", "the", "carboxy-terminal", "amine", "norephedrine", "." ] } ]

PMC11011837

In fact, both Molt-16 and Molt-4 demonstrate higher levels of PC and PE in comparison to the Jurkat and CCRF-CEM cell lines.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "both", "Molt-16", "and", "Molt-4", "demonstrate", "higher", "levels", "of", "PC", "and", "PE", "in", "comparison", "to", "the", "Jurkat", "and", "CCRF-CEM", "cell", "lines", "." ] } ]

PMC11640247

However, this variant showed minimal effects on SRF-, NFκB-, and AP1-mediated gene expression pathways, which are downstream of Rho family proteins .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "this", "variant", "showed", "minimal", "effects", "on", "SRF-", ",", "NFκB-", ",", "and", "AP1-mediated", "gene", "expression", "pathways", ",", "which", "are", "downstream", "of", "Rho", "family", "proteins", "." ] } ]

PMC11317131

Additional primers were generated to amplify successful insertion at ROSA26.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "primers", "were", "generated", "to", "amplify", "successful", "insertion", "at", "ROSA26", "." ] } ]

PMC9429973

One patient had delayed grade 4 leucoencephalopathy (MRI/brain biopsy were more indicative of fludarabine toxicity than CAR T related) and has ongoing neurological recovery.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "had", "delayed", "grade", "4", "leucoencephalopathy", "(", "MRI/brain", "biopsy", "were", "more", "indicative", "of", "fludarabine", "toxicity", "than", "CAR", "T", "related", ")", "and", "has", "ongoing", "neurological", "recovery", "." ] } ]

PMC9429973

Image: Summary/Conclusion: A novel scoring system—the TM frailty score—was developed by combining the TUG (T) and MNA-SF (M).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "A", "novel", "scoring", "system", "—", "the", "TM", "frailty", "score", "—", "was", "developed", "by", "combining", "the", "TUG", "(", "T", ")", "and", "MNA-SF", "(", "M", ")", "." ] } ]

PMC11566417

Different letters on graphs indicate statistically significant differences between groups Mammosphere derived epithelial cell (MDEC) culture growth kinetics and cell composition are variably affected by immortalization and passage.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "letters", "on", "graphs", "indicate", "statistically", "significant", "differences", "between", "groups", "Mammosphere", "derived", "epithelial", "cell", "(", "MDEC", ")", "culture", "growth", "kinetics", "and", "cell", "composition", "are", "variably", "affected", "by", "immortalization", "and", "passage", "." ] } ]

PMC11307990

All oligonucleotides were purchased from Sangon Biotech (Shanghai, China).

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PMC9429973

Aims: Therefore, we aimed to assess the predicting power of different RAMs for TE development, coupled with diagnostic algorithms that distinguish the objective need for radiological diagnostic procedures (colour duplex scan (CDS) and computerized tomography pulmonary angiography (CTPA)).

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PMC9874064

Finally, the therapeutic effect of NP-Pt-USP1i was further verified by H&E and TUNEL staining.

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PMC11656657

These findings indicate that the level of GD2 expression is critical for the efficacy of CAR.GD2 T-cell therapy in sarcomas, highlighting the need for accurate assessment of GD2 levels in tumors before initiating CAR T-cell immunotherapy.

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PMC6160470

Cellular signalling proteins affected by crown ethers.

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PMC8978939

In the past years, research has demonstrated that the SUMOylation of pVHL by the protein RSUME prevents the formation of the VBC complex, thus HIF-α is not degraded even under normal oxygen conditions (15, 16).

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PMC5925824

n = 8 for all groups.

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PMC11718274

The effect of Y2O3NPs on ROS generation in cancerous A-431 cells was investigated using the 2,7-dichlorofluorescin diacetate (DCFH-DA) dye.

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PMC9429973

Methods: We examined the bone marrow cells of 268 newly diagnosed AML patients using conventional karyotyping in combination with FISH (Abbott, MetaSystems) and mFISH/mBAND (MetaSystems).

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PMC11697703

We carried out bioinformatic analyses to identify predicted targets of miRs-193b and 365 using miRanda, Targetscan, DIANALAB, and miRDB.

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PMC10376064

The present study addresses two important aspects of the potential use of DMF as a repurposed anti-AD drug.

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PMC9429973

As the pathophysiology of ABC-DLBCL involves a chronically active B-cell antigen receptor pathway, it was hypothesised that higher-risk ABC-subtype population may benefit from a Bruton’s tyrosine kinase inhibitor, such as ibrutinib.

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PMC8592717

PCA pre-administration suppressed the cadmium chloride (CdCl2)-induced apoptotic events through inhibition of mitochondria-caspase signaling pathway and mitigated Cd-induced neurotoxicity by activating Na+/K+-ATPase, butyrylcholinesterase, acetylcholinesterase, and antioxidant enzymes .

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PMC11122631

Nine fractions (A–I) were collected by eluting with hexanes/EtOAc/MeOH (8/1/0 to 0/0/1).

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PMC11730311

CHO-K1 cells stably expressing the human calcitonin gene-related peptide receptor (PerkinElmer #ES-420-C stable monoclonal hCGRP-R cell line) were thawed from frozen cell stocks immediately before assays.

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PMC11741906

A lot of research has employed experimental models particularly A2780, A2780DDP, and SKOV3 to investigate the impact of specific miRNAs on cisplatin treatment response.

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PMC11806182

The robustness of these results was further confirmed through sensitivity analyses (Fig. 6C).

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PMC11381192

Circos plot representing the significant Spearman correlations across five cell stress indexes.

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PMC11471157

Its efficacy was then evaluated as a microcarrier in spheroid cultures.

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PMC7582629

All-Trans-Retinoic Acid (ATRA) was used as control drug and it is generally used for acute promyelocytic leukemia treatment where the drug is unable to induce B-ALL regression.

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PMC11021472

CircRNAs can encompass single or multiple exons, with or without the presence of (part of) introns.

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PMC11012012

By flow cytometry, SLAMF5/CD84 cell surface levels were significantly higher in all CLL cells when compared with total or CD5+ normal B cells.

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PMC11449273

p53 stability and function are regulated by various post-translational modifications such as phosphorylation, acetylation, sumoylation, methylation, and interactions with other proteins including plakoglobin.

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PMC10158546

Cells were then blocked with 10% goat serum+1% BSA in PBST for 1 h at room temp before incubating with primary antibodies in blocking buffer overnight at 4°C.

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PMC11468365

As mentioned before, the MultiComb model is an end-to-end MTDL model.

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PMC9780037

To ensure their specific targeting to cancer cells, some of these pocket structures were modified on their surface with ligands that bind specific molecules on the surface of cancer cells, triggering their endocytosis (Table 3).

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PMC11763764

Cell cycle phase distributions were analyzed with Flow-Jo v. 8.7.

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PMC9429973

2.

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PMC2118063

Values in B and C indicate SD.

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PMC10729469

Following starvation, cells were incubated with a previously optimized non-toxic concentration, 1 mCi/mL F-FDG, for 1 h at 37 °C to allow uptake of radioactive glucose.

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PMC4395774

.

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PMC9429973

On the contrary, select patients with FLC ratio ≥100 can be followed for many years without progressing and some may never progress despite long-term follow-up.

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PMC11640247

RAC1 is ubiquitously expressed, while RAC2 is mainly found in hematopoietic cells, and RAC3 is predominantly expressed in the brain .

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PMC11757230

After 72 h, the floating LL cells were separated from the cADSCs by gentle pipetting or by removing the membrane.

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PMC11673902

This exchange is manifested macroscopically as the sound wave exerts a force on the object, called the acoustic radiant force (ARF) (Figure 7).

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PMC11607638

The wild‐type A. aegypti Rockefeller strain was reared at 24–27°C with 70% relative humidity in The Insectary at Hainan University.

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PMC7802142

Stem cell-derived EVs are believed to inherit the growth-promoting properties of stem cells.

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PMC11806182

These experimental data suggest that these drugs could modulate critical biological pathways in UCEC, potentially impacting disease progression and providing insights into therapeutic strategies.

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PMC11400680

Figure 8 depicts bar plots illustrating the counts of cells and nuclei segmented by our proposed method.

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PMC10656496

This differential response to glutamine stood out as a selection pressure parameter to explore further.

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PMC10758402

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

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PMC10440586

To further explore the impact of CD99 expression on ICB therapy, we analyzed a cohort including primary and secondary surgery samples from 27 patients with recurrent glioma who received neoadjuvant nivolumab therapy .

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PMC4695073

Cisplatin and other platinum-based antitumor drugs have been exerted on a wide range of tumors including testicular, head and neck, lung, ovarian, bladder cancers .

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PMC11377827

Control vs. USP43 sgRNA +Rox *P = 0.0269.

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PMC5874706

The in vitro release experiments were performed in order to confirm what has previously been observed in similar systems: the benefit of nanoparticle encapsulation.

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PMC11792888

Representative histograms of the cell cycle in the CHO-K1 cell line, after scorpion venom treatment for 48 h. Bar graph summary representing the percentage of cells in G0/G1, S, and G2/M in CHO-K1cells. (

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PMC11225860

Two mice in the Aurkin A and one mouse in the Alisertib treatment groups did not exhibit tumor growth post cell injection and were excluded.

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PMC11477621

Subsequently, a pharmacokinetic study of compound 20 was conducted in male ICR mice.

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PMC11761919

The release of bacteria from the microcapsules was completed within 30 min.

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PMC11650848

It would be of value to identify if these CTCF sites have insulator effects or form loops for regulation of genes in different loci.

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PMC9592219

The proteins in the gels were translocated in polyvinylidene difluoride membranes after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

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PMC11257203

Part of this effect might be through modulating oxidative stress markers, such as a reduction in MDA level and an increment in the level of GSH.

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PMC9429973

Further studies with larger sample size and longer follow-up are required to confirm our conclusion.

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PMC11730320

In addition, γδ T cells have lower TCR repertoire diversity than αβ, are found predominantly within epithelial and mucosal tissue, and are thus considered to play an intermediate role between innate and adaptive immunity.

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PMC11585587

Notably, the IC50 values for MM.1 S cells were 1.616 µM at 24 H and 1.058 µM at 48 H, for MM.1R cells were 3.905 µM at 24 H and 2.18 µM at 48 H, while for RPMI 8226 cells, they were 6.091 µM at 24 H and 3.438 µM at 48 H (Fig. 1).

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PMC11683240

A–B, PT (100 ng/ml = 0.000952 μM) and different concentrations of α1AT or the respective amount of solvent (H2O) were added directly to CHO-K1 cells and incubated for 4 h at 37 °C.

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PMC11411004

To identify useful small-molecule regulators that enhance the expression of recombinant proteins in Chinese hamster ovary (CHO) cells, we examined a novel dual-HDAC/LSD1 inhibitor I-4 as a supplement for recombinant CHO cells.

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PMC9429973

Twenty-five pts were on active treatment for IBD at the time of MN diagnosis (9 on biological agent, 11 on mesalamine, and 2 on azathioprine), whereas 18 were in remission.

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PMC11307990

Results in the left were compared using one-way ANOVA, *** p < 0.001.

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PMC11093197

Cells were washed with PBS and were fixed with 4% PFA at RT for 10 min.

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PMC11354225

Cells were seeded in 24-well plates, at a total of 1 × 10 cells/well.

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PMC10761571

Data are stated as mean ± SD.

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PMC9386809

The resulting mixture was heated at 110 °C for 12 h. The reaction mixture was cooled to room temperature, and dry diisopropylethylamine (7 mg, 0.0546 mmol dissolved in 1 mL of dry toluene) was added.

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PMC8623816

Here, we describe a novel double-stranded (ds) RNA mycovirus designated Rhizoctonia solani dsRNA virus 5 (RsRV5) from strain D122 of Rhizoctonia solani AG-1 IA, the causal agent of rice sheath blight.

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PMC11476222

The ganglioside biosynthesis pathway and MS traces of the gangliosides identified in the cell lines are shown in Figure 5.

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PMC11552389

These findings suggest that FOXN3 may be an attractive therapeutic intervention target for overcoming melanoma tumor drug resistance.

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PMC11788920

The symbols are data points and lines are Hill function fit to the respective data.

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PMC9429973

The 6 cycles of ZR-CHOP plus 2R were administered as induction therapy, with no maintenance.

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PMC9812014

Oxoglyantrypine alkaloid derived from the marine mangrove plant-fungal strain Cladosporium sp. was noted to have a repressive effect against the IAV with an IC50 of 85 μM; other alkaloids derived from this fungal strain were Norquinadoline A, Deoxynortryptoquivaline, Deoxytryptoquivaline, Tryptoquivaline had also a reported inhibitory effect with an IC50 of 82, 87, 85, 89 μM, respectively, against IAV .

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PMC11541241

Host‐induced gene silencing (HIGS) is an RNA interference (RNAi)‐based natural method used by plant hosts to transfer small RNAs (sRNAs) to defend themselves against invaders (Baulcombe, 2015).

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PMC10547921

Therefore, in order to further expand the range of ADC payloads and identify other types of ADC payloads that are effective in both fast and slow-proliferating cells and can escape MDR-mediated resistance, attention has turned to small molecular payloads targeting RNA.

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PMC8557138

Hydrogels, soft polymer materials containing 3D structural networks, are preferred for the construction of vascular tissues due to their ability to retain water in 3D networks.

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PMC11673902

This technique not only improves the accuracy of single-cell analysis but also extends the range of applications of cell mechanics research.

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PMC11711871

Differences were assessed at *P < 0.05 and ****P < 0.0001Fig.

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PMC11703896

To address these challenges, future studies could explore receptor-specific analogs or targeted delivery systems, aiming to optimize rapamycin’s efficacy while minimizing risks to normal tissues (Figs. 4, 5).

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PMC11747949

Our coculture system is considered indirect as it lacks cell‐to‐cell contact and relies on communication via secretory factors (Rasouli and Safari 2024).

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PMC11209164

The extraction of total RNA from both infected and mock-infected 786-0 cells was conducted using the RNeasy Mini Kit, following the instructions provided by the manufacturer. (

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PMC10079526

In addition, our in vivo experiments showed no significant reduction in tumor outgrowth in response to SUMOylation inhibition as single compound therapy, whereas literature suggest that SUMO abolishment by genetic knock down of the E1 enzyme does reduce tumor outgrowth in MYC dependent tumors .

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PMC9429973

In both parts, median prior LOT was 5 (range 3–13); 10 pts (29%) had high-risk cytogenetics and 9 (26%) had extramedullary disease.

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PMC11638255

This phenomenon did not occur in untreated neuroblastoma cells, indicating that copper chelation therapy modulates levels of copper in the tumor microenvironment to facilitate copper uptake by neutrophils.

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PMC11650848

Several cognitive results were compared for correlations with the mQTL genotypes and their methylation patterns.

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PMC11725127

The precipitates pulled down by biotin–GA or biotin from MM.1S or RPMI 8226 cell lysates were examined by western blotting with anti-USP2 antibody. (

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PMC8916024

In general, the bacterial diversity in the sediment samples was significantly higher than that in the snail guts (P < 0.001), and there was no significant difference in the diversity of the gut flora of adult and juvenile snails (P > 0.05), as assessed by the Sobs, Shannon, Chao, and ACE indices (Fig. 1B).

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PMC10887351

β2-ARs, which display a higher affinity for A, are localized in the liver, skeletal muscle and in gastrointestinal and bronchial smooth muscle cells.

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PMC10198699

Now that it has been established that HBM in the research context is susceptible of ownership, that the transfer of ownership by the research participant to the research institution is peremptory, and that HBM and the information contained therein are not regulated by POPIA, I consider the three scenarios.

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PMC10907726

Fig. 3Fig.

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PMC11371747

Cell culture flasks were purchased from Greiner Bio one (Alphen aan de Rijn, Netherlands).

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PMC9739791

The first one is the photocatalytic strategy based on the flavin derivatives that are not covalently bound to the Pt(IV) substrate.

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PMC11585994

The gel displays G5, sgc8, and siBCL11B, along with siBCL11B combined with sgc8 and G5. (

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PMC11762280

Epidermal thickness was measured in three randomly selected fields of view of non-necrotic epidermis in H&E-stained sections, and the values were averaged to assess the degree of epidermal edema and hyperplasia.

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PMC11588085

Altogether, our data suggest that XIST plays a crucial role in cellular plasticity and identity.

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