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PMC10048572
Currently, many works are devoted to chemotherapy-induced clonal evolution.
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PMC11656048
Moreover, MDA is one of the important products of ferroptosis, so we subsequently detected the changes of MDA in MG63 and 143B cells.
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PMC11787355
U87 TMG cell line was prepared at a concentration of 4 ×10 cells/ml in PBS-Matrigel mixture at a ratio of 1:1.
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PMC11394730
Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research.
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PMC11699178
A total of 50 μg of protein was loaded per sample.
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PMC11704135
H-NMR spectrum (CDCl3) of compound 12 showed the chemical shift (δ = ppm) at 1.00–1.18 (t, 3H, methyl protons of ethyl group), at 2.29 (s, 6H, pyrimidine methyl protons), at 4.29–4.35 (q, 2H, methylene protons of ethyl group) and 7.28 (s, 1H, aromatic protons of pyrimidine ring).Fig.
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PMC10178190
In conclusion, our study described the role of components of the tumor microenvironment active in promoting platinum chemoresistance and their suggested role in the failure of cancer therapy.
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PMC11721587
After the in vitro transcription reaction, streptavidin beads were removed by centrifugation, and the resultant supernatant was treated with 20 U of deoxyribonuclease I (DNase I) at 37°C for 20 min.
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PMC11621493
The PLA2G4 family comprises six members that share structural similarities and are referred to as PLA2G4A-F or cPLA2α-ζ.
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PMC10213199
From functional clustering, we have concluded that these genes predominately regulate the functions of RNA polymerase.
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PMC10898159
In vitro, the over-expression of miRNA-221/222 causes cell cycle arrest, apoptosis induction, and the inhibition of cell proliferation via decreasing KIT expression in erythroleukemic cells and erythropoiesis .
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PMC9429973
Our regime (Flu/Cph+R) showed a significantly deeper lymphodepletion, with less toxicity and a reduced incidence of infectious complications.
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PMC7802142
During telogen phase, the depilated skin of C57BL/6 mice is pink, while it darkens at initiation of anagen .
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PMC11747467
These results indicate that a compensatory mechanism for STAT3 activation exists following RC48 exposure, suggesting that targeting STAT3 could be a feasible strategy for combining RC48 against basal bladder cancer.
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PMC11464609
The detection of BoDV-1 reads with significant coverage in seven out of nine samples is likely due to carryover from the original library.
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PMC11621493
In our study, we identified PLA2G4D as a cytosolic lipid hydrolase and transacylase.
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PMC7369657
The tumor weight of the CQD-treated group was 2.0 ± 1.1 g, which was lighter than the control group (2.9 ± 0.9 g).
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PMC11552389
FOXN3 mediated suppression of melanoma cell proliferation, migration, and invasion. (
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PMC11745600
Some mice exhibited a transient decrease in blood glucose levels after transplantation, which was likely attributed to insulin released from disrupted hSC-islet cells following transplantation.
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PMC10523483
GSH levels in tissues and cultured cells were measured using a GSH and GSSG (oxidised glutathione) assay kit (Beyotime).
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PMC5916734
Panel B – FIX secretion level and the degree of propeptide processing for cell populations and clonal lines.
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PMC10747139
The former was evaluated by determining the IC50 value, that is, the inhibitory concentration that prevented 50% of the poly(A) RNA to be reverse-transcribed to poly(dT) cDNA by the M-MuLV RTs, whereas for the latter, the EC50 value (that is, the effective concentration required to cause 50% inhibition activity toward the HIV-1 RTs) was determined in comparison to etravirine (EC50 = 0.0177 ± 0.0014 µM).
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PMC10470467
However, a study also reported that many cancer cells could induce endothelial necroptosis to facilitate extravasation and metastasis (9).
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PMC11546117
The aim of the present study was to develop and characterize a human cell-based in vitro model capable of quantifying the transfer of xenobiotics across the blood–milk barrier.
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PMC11413393
Cell lines were engineered to express doxycycline (Dox)-inducible PRMT1 targeting or non-targeting (NT) shRNAs and treated with or without 1.0 μg/mL Dox for 3 and 6 days.
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PMC11389534
The differentiation of plasma B cells stimulates a transcriptional increase of UFBP1 through XBP1s pathway.
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PMC11740399
After 24 h of incubation to investigate the concentration of 3025@ML and 3 K that has an anti-tumor effect, the cells were treated with a medium containing either varying concentrations (0.1, 1, 10, 100 µM) of 3025@ML or 3 K for 48 h. To assess the impact of 3025@ML and 3 K on OXA, cells were plated following the previously described method and subjected to treatment with the control, 3025@ML, 3 K, OXA, 3025@ML + OXA, and 3 K + OXA.
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PMC9014716
Moreover, an in-depth study reported that Huaier granules can be used to modulate miRNAs to achieve silencing of target genes.
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PMC11687663
The culture media was removed without disturbing the formed crystal.
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PMC11248911
Similarly, root mean square fluctuations (RMSF) based on the protein C-alpha atoms were calculated using gmx_rmsf.
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PMC11391695
That is, cytoplasmic ACYP2 inhibits K efflux and ERK pathway by interacting with KCNN4 to impede the malignant progression of HCC; Nuclear ACYP2 impedes the progression of HCC by inhibiting the activity of TERT, leading to shortening of telomere length and inhibiting cellular immortalization.
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PMC11055323
A P-Value < 0.05 was considered as statistically, *p < 0.05, **p < 0.01, ***p < 0.001, ****P < 0.0001.
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PMC9429973
To consider strong hypotheses for the drug profile-immune gene expression associations, we considered tau> 99 and selected top 26 candidates ranked by tau score.
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PMC7171147
Since we have shown that Src and Akt are activated by COL11A1 binding to DDR2 and α1β1 integrin, we next determined whether activation of Src and Akt is necessary for the COL11A1-induced FAO upregulation in ovarian cancer cells.
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PMC9429973
Immunotherapies, such as anti-PD1 antibodies, may induce hyperprogression in certain PTCL subtypes.
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PMC11401358
Silk fibroin (SF) is a natural protein-based biopolymer with hierarchical mesoscopic structures containing secondary structures, β-crystallites and nanofibrils .
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PMC11798926
This work inspired us to explore whether the SynDIGs also harbor endocytic signals which could interact with μ2 and the μ subunits of other adaptor complexes which are involved in many different intracellular trafficking pathways (Guardia et al., 2018).
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PMC9429973
The most frequently used (in more than 10 trials) MPN-specific PROMs were MPN-SAF TSS (or MPN-10) and MF-SAF (including v2.0 and v4.0).
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PMC11515150
To evaluate proliferative effect on account of IL-15, we compared the proliferation of NK supplemented with 500 IU/mL IL-2 and 28 ng/mL IL-15 to that of NK only supplemented with 500 IU/mL IL-2.
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PMC9429973
The overall median time to best response was 81 days from end of treatment.
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PMC10178190
Our data show that the Crizotinib/HGF combination significantly decreases cell proliferation in all samples, as well as increased cPARP levels, showing that Crizotinib blocks HGF’s platinum resistance activity and restores platinum sensitivity to OC cells.
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PMC7841189
The present study was approved by the medical ethics committee of the Linyi Tumor Hospital, and informed consent was obtained from each patient.
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PMC9429973
Negative correlation between the HSM and the number of P for each group was found (p<0.01).
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PMC11696659
In Spain it was estimated that 21.918 patients died from lung cancer in 2020, and 30.948 new cases were diagnosed in 2022 .
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PMC11727000
As cell lysis was performed under fully denaturing conditions, non-specific and post-lysis interactions were minimized.
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PMC11757230
However, it is important to consider that MSCs may indirectly promote or inhibit tumor growth by affecting the immunogenicity of tumor cells and the antitumor immunity of tumor-bearing animals because of their immunomodulatory properties that regulate immune cells involved in both innate and adaptive immunity .
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PMC10452486
Upon further cellular differentiation, the percentage of cells expressing L31-reactive molecules on the cell surface increased from 45 to 80%.
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PMC11349530
Apparently, there are no exclusively pro-tumor cytokines and other immunoregulatory factors (IRFs), but it can be assumed that their production by tumor cells is always unfavorable and is a potential target for antitumor therapy.
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PMC11547972
Following 5–10 days of incubation without medium change during this time, cell colonies were fixed and counted.
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PMC9429973
CART19, NALM-6 and macrophages differentiated from THP-1 upon PMA stimulation were cocultured and IL-6 in the supernatants was detected by cytometry bead assays.
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PMC11301242
The detailed statistical methods were annotated within the relevant figure legends.
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PMC11534377
The cDNA was diluted 1:5 and then further used for the RT PCR analysis for gene expression.
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PMC9954564
Afterward, the ancestry components obtained for each individual were included as covariates in a logistic regression model using PLINK v.1.9 to correct the associations for population structure.
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PMC11201989
Disruption of the proper functioning of the IFT machinery may lead to the inability to transduce or cause inappropriate activation of the Hh pathway .
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PMC10577955
This cascade negatively affects cell growth and triggers cell apoptosis .
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PMC2614415
Mammalian genomes contain three members of this kinase family, Aurora-A, B and C. Aurora-A was first characterized in Drosophila melanogaster where mutants exhibited defects in centrosome separation .
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PMC11678841
The samples were then stored at −20 °C until use.
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PMC9621239
The activity of the firefly luciferase reporter was normalized to that of the Renilla luciferase.
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PMC9844987
The left subpanels display the distribution of IQRs (widths containing the 25th to 75th percentiles of contained CAGE signal) (A) and the number of TSSs with expression fraction ≥ 5% in 25% of samples (B).
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PMC11506670
In contrast, G48C, E37K, and the canonical Q61K control showed decoupled anti-apoptotic effects in the wild-type background of NIH3T3 cells.
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PMC11622247
The absorption band at 550 nm indicates dye–dye contact in the absence of target RNA.
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PMC11720107
Our experiments showed that after 24 h of exposure of BJ cells to the tested extracts, the Ornak, Violeta, and Morado cultivars significantly increased CAT protein expression by 8.1 ng/mL, 3.6 ng/mL, and 5.3 ng/mL, respectively, compared with the control (Figure 8A).
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PMC6889484
Figure 7Efficient Transduction of CD4 T Cells and CD34 HSPCs with the A3x3G-D128K-Expressing Vector(A) CD4 T cells from 5 donors were transduced with A3x3G(DK) vector virus at an MOI of 10, and the proportion of eYFP cells was determined by FACS 72 h post-infection. (
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PMC11696659
Here we use TAT with the main objective of evaluating the possibility of using telomere length measurements in peripheral blood lymphocytes as potential diagnostic biomarkers in patients at high risk of lung cancer.
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PMC10170482
In fact, we revealed that ΔΨm was significantly higher for cells grown under stiff MC conditions in comparison with cells cultured on soft 3D CS (Figure 4D,E).
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PMC8633974
We next evaluated the specificity of our tat-directed CRISPR-Cas9 by comparing the degree of proviral genome editing to that observed in off-target loci.
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PMC3035438
Lane 2: parental WT showing no expression of chimera IgG. Lanes 3, 5 and 7: CX13 coexpressing chimeric IgG and chicken IgM. Lanes 6 and 8: CX13 after deglycosylation with PNGase F. (D) Sequence diversification induced in the Ig variable region after culture expansion for 6 weeks in presence of TSA.
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PMC7305184
The other part became a control, which was once exposed to electric pulses (CTRL + EP).
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PMC11754784
Scale bar: 10 μm.
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PMC10758402
Notably, there was no concurrent increase detected in the CD4 and CD8 at any time point, suggesting this could be attributable to a rise in double-negative T-cells ( Figure 6B ).
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PMC11092382
Researchers further demonstrated that sophocarpine treatment suppressed the proliferation, migration and invasion of two castration-resistant prostate cancer cell lines, DU145 and PC-3 by deactivating the PI3K/AKT/mTOR signaling pathway (Weng et al., 2022a).
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PMC9429973
Grade 3+ neutropenia <3 months prior to infection was identified in 15, anti-CD20 antibody therapy < 6 months in 14 and AuSCT <2 years in 4.
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PMC11761919
In this study, recombinant bacteria encapsulated with sodium alginate induced higher levels of IgG and sIgA, T-lymphocytes proliferation and neutralizing antibody titers compared to unencapsulated bacteria, which is ascribed to that sodium alginate microspheres protect the target recombinant bacteria from degradation in the low pH environment of the proventriculus and gizzard of chickens, thereby maintaining a higher survival rate upon reaching the intestinal mucosa and stimulating stronger intestinal mucosal immune responses.
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PMC11640115
The Combined Positive Score (CPS), used as a biomarker in the KEYNOTE-048 trial, is now widely used in clinical practice as a complementary diagnostic method .
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PMC5839394
The data are expressed as mean value ± SD.
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PMC6835428
Made of RNA, siRNAs are characterized by a negative electric charge and have poor stability in the biological environment.
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PMC10993311
There are specific biochemical parameters for this period of life, which are suitable for the monitoring, diagnosis and prevention of diseases that can affect pregnant women and their fetus (Teasdale and Morton, 2018).
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PMC10759659
b, c ARID1A mRNA showed no significant difference between the two groups.
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PMC10994876
Additionally, it enhanced the volumetric production of EPO (b) and the specific productivity of recombinant EPO in EPO-CHO cells (c).
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PMC11506670
NIH3T3 has a wild-type background, and is a preferred and well-documented heterologous host for studying RAS mutations because of its ability to manifest oncogenic phenotypes upon sole expression of a transforming Ras variant, without requiring cooperative mutations .
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PMC7351993
As illustrated in Supplementary Fig. 3a, the RIACS has an event detector at the optical interrogation point to detect events (e.g., single cells, clustered cells, debris) in the view window of the SRS microscope (Supplementary Fig. 2a).
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PMC11770130
Frozen adipose tissues were lysed using Dounce homogenizers in lysis buffer (20 mM HEPES pH 7.5, 15 mM MgCl2, 150 mM KCl, 1% NP-40, 100 µg/mL cycloheximide, 1 mM DTT, 0.1 U/μL RNase inhibitor, and 1× Halt EDTA-free protease inhibitor) and incubated on ice for 15 min with vortexing every 5 min.
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PMC4270159
We are including two additional control conditions;Media alone.a.
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PMC11547917
The short-term exposure (up to one year) to AAs lead to aristolochic acid nephropathy (AAN) , and a longer term exposure (up to several decades) can lead to Balkan endemic nephropathy (BEN) .
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PMC8584666
Neither mRNA nor flow cytometric analysis showed a correlation between cell line malignancy and spontaneous GPI-80 expression levels.
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PMC11297139
e Representative confocal images of 293T cells expressing GFP-ARID1A at different fluorescence intensities.
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PMC11365427
Image created with BioRender.com with permission). (
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PMC11307990
The first lane was 6HB-DONs.
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PMC11335267
J and K) Oxygen consumption and energy expenditure during acute exercise on the treadmill (n = 8 per genotype). *
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PMC11082662
Using the “limma” package in R software, we extracted the differential expression results for the 2,059 secreted proteins and depicted the results in a volcano plot.
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PMC11449273
Target mRNA expression levels were normalized to the amount of ACTB mRNA in the same cell line.
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PMC10237474
Chain B of the protein complex expressed in CHO-K1 ran as a smear under reducing SDS-PAGE, suggesting heavy glycosylation (Fig 7B).
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PMC11718817
This might also be caused by the dispersed presence of model antigen OVA in an already dissolving spheroid, due to cytotoxic efficacy of T cells.
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PMC11783017
Immunofluorescence images of RAW264.7 cells showing M2-type macrophages (CD206, green), M1-type macrophages (CD86, red), and cell nuclei (DAPI, blue). (
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PMC11748618
Genetic variants that had at least one functional marker in blood tissues were selected for follow-up.
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PMC10578720
The liver tissues of vehicle-treated rAAV-1.3 HBV mice exhibited a stronger collagen deposition increase than normal mice (Figure 8D).
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PMC9429973
Methods: In this trial (NCT04823091), anti-CD7 CAR T cells were manufactured from HLA-matched sibling donors or autologous mononuclear cells and administrated to 10 participants at a dose of 1×10 (n=5) or 2×10 (n=5) cells/kg.
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PMC11739696
To measure the mRNA expression level of the p53, Bcl2, and ND3 genes, a separate qRT-PCR was performed for each sample using the StepOnePlus Real-Time PCR System (Applied Biosystems).
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PMC7582629
The PCA loading can detect spectral differences in cell states and identify the associated biomolecular changes .
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PMC9429973
Image: Summary/Conclusion: This study has provided the largest series of patients with heterozygous β-thalassemia associated with α-globin gene triplication.
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