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PMC10994876
Based on these findings, it can be concluded that the overexpression of YAP results in an increased phosphorylation of S6K.
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PMC8973725
However, additional studies are required to explore the exact molecular mechanisms underlying the effects of ZNF677 on ccRCC cell EMT.
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PMC9429973
Previous studies showed growth inhibition of multiple tumor xenografts (lung and colon carcinomas) mainly due to a direct antitumor effect.
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PMC11409031
In recent years, immunotherapy, especially research on T cells, has provided new hope for the treatment of OV.
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PMC11186948
Genomic DNA of patient (#249) and its parents was extracted from blood and saliva samples by Wizard Genomic DNA Purification Kit (A1120, Promega) and Quick-DNA Miniprep Plus Kit (D4068, Zymo Research) respectively.
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PMC10743717
If the reported kinetic constants of ERAB/ABAD are taken for granted, the enzymatic reaction would already be completed before the first data point was observed at 5 min.
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PMC9429973
Pts in LIT with VEN group were more likely to receive reduced-intensity conditioning (92%) prior to SCT, compared with 53% and 58% in the IC and LIT without VEN groups, respectively (p<0.01).
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PMC11794847
Once they reached approximately 70–80% confluence, Jurkat T cells, cultivated in RPMI 1640 supplemented with 10% FBS, were placed in the upper chamber of a 0.4 μm pore-sized membrane insert.
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PMC11116779
Preliminary data (not shown) indicated that it will allow detection of PS-NPs 800 nm.
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PMC6222726
When the pits mature, they are covered by a yellow or red pseudoaril.
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PMC11026382
These p values were compared to a multiple-hypothesis testing adjusted p value determined by Sequential Goodness of Fit (P = 0.035 for TYMS Q33S and P = 0.029 for TYMS R166Q).
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PMC11380454
We first tested the effects of SAS and AS101 on PD-L1 protein expression on the surface of diverse human and mouse malignant cells.
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PMC9429973
Response Rates: The first-line therapy was cyclosporine (CsA) mono therapy in 52.7%, CsA and rabbit thymoglobulin (rATG) in 38.8% and CsA/danazole in 8.3%.
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PMC11640115
A past study showed no correlation between pretreatment CRP and the response rate .
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PMC11696659
Life Length SL.We searched PubMed for reviews, observational studies, clinical trials, and cohort studies in the use of telomeres as biomarkers for diagnosis and prognosis of lung cancer up to October 1st, 2022, using the terms “telomere” or “telomere length” in combination with each of the following terms: “lung cancer”, “NSCLC”, or “chronic obstructive pulmonary disease”.
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PMC11769516
In both analyzed groups, after 3 and 5 days, higher levels of total nitric oxide synthase, nitric oxide, hydroxyl radical scavenging and MDA were noted.
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PMC10772747
By inhibiting Bcl-2 expression, P53 strengthens the apoptotic pathway induced by Bax (Issaeva, 2019).
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PMC11739696
This increase was indicated by the higher intensity of fluorescent light emitted from the CoO NP-treated melanoma A-375 cells compared to the fluorescence from untreated A-375 cells (Fig. 5).
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PMC10887351
They observed that β3-AR expression, similarly to VEGF, depended on oxygen tension.
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PMC11463018
H NMR (400 MHz, DMSO-d6) δ: 8.66 (s, 2H), 8.27 (s, 1H), 7.58 − 7.53 (m, 1H), 7.49 − 7.44 (m, 1H), 7.29 − 7.24 (m, 1H), 6.14 (s, 2H).
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PMC11754291
After the final irradiation on day 7, the collected keratinocyte-conditioned medium (CM, CMK, or CMiK) was concentrated 10-fold using centrifugal concentrator (Vivaspin 6 centrifugal filtration unit, Sartorius) following the manufacturer’s guidelines, and then stored at −80°C.
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PMC11566417
Accession codes for each identified protein were extracted and the ‘ggvenn’ and ‘upset’ functions were used to generate a Venn diagram and UpSet plot of overlapping and unique proteins identified by condition.
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PMC10671321
Experiments with MLCL −/− cells infected with ColQ1a WT-mycTag or ColQ1a E418HfsX-mycTag viral constructs were also repeated 3 times.
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PMC11791203
Table 2IC50Values of chloroform and petroleum ether extracts on HT29 and HaCaT cell lines.
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PMC11803918
The morphology of processed nanoparticle samples was imaged under a Philips CM100 Transmission Electron Microscope (Philips).
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PMC11507371
For assays, 2 × 10 A431 and HaCaT cells were seeded into a 96-well Cellstar microplate (Greiner Bio-One GmbH, Frickenhausen, Germany), reaching a final volume of 100 μL per well and cultivated for 24 h, unless indicated otherwise.
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PMC10507284
CPM, counts per million; STS, soft tissue sarcoma; HSF, human skin fibroblast cell line; SW982: the human synovial sarcoma cell line. *
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PMC11261875
Kohei Taniguchi: Writing – review & editing.
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PMC11335267
MC4R, predominately expressed in the paraventricular nucleus that receives projections from the ARC, is known to regulate food intake, body weight, and energy homeostasis, and consistently, lack of function of this receptor in mice and humans results in hyperphagia and obesity .
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PMC4270159
We will then perform additional replicates, if required, to ensure that the experiment has more than 80% power to detect the original effect.
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PMC11544122
Unphosphorylated (CT-WT), phosphorylated (pCT-WT; pS324/325/338/339) or phosphomimetic (CT-EE; S to E substitution at S324/325/338/339) peptides were used.
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PMC11661040
The results demonstrated a significant increase in the expression level of CGREF1 in transfected cells (Fig. 3A-C).
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PMC9429973
In recent years, with the clinical application of Next Generation Sequencing (NGS) technology, it has been found that CML patients are often accompanied by non-ABL1 kinase region gene mutations, but whether these accompanying mutations are related to the efficacy of TKIs and disease progression in CML?
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PMC10297204
Although migration or invasive capacity has not been evaluated with high concentrations of ethanol in the past, previous reports have reported that ethanol inhibited cell migration and invasive ability by suppressing the Notch signaling pathway (Notch1, Jagged1, and c-Myc) .
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PMC11740907
The formula that is most often used is:22,33,34 [12pt] [substack] [mathscr] $$}}^}}}$$ The various mice groups and the therapies they received are listed in Table 2.Table 2Control and Experimental Animals Given Pure P5W30, P5W30-BW-SLNs, and CisplatinGroupType of Treatment1Mice afflicted with cancer without treatment2*Mice afflicted with cancer were administered BW-SLNs3*Mice afflicted with cancer were administered 30 µg/kg cisplatin4*Mice afflicted with cancer were administered Pure P5W30 (30.87 µg/kg)5*Mice afflicted with cancer were administered P5W30-BW-SLNs (14.72 µg/kg)Notes: *The test compounds were administered to groups 2–5 as a single i.p dose throughout the trial.
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PMC11672142
Given the virtually 100% antiproliferative behavior exhibited by DefNEtTrp against all leukemia cell lines in the NCI screen, a more in-depth analysis of its activity was performed against the leukemia Jurkat cell line as a case study.
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PMC9429973
The most common gastrointestinal TEAEs were diarrhea (bosutinib vs imatinib: 75.0% vs 40.4% [G3/4: 9.0% vs 1.1%]) with bosutinib, and nausea (37.3% vs 42.3% [G3/4: 0% vs 0%]) with imatinib.
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PMC11129910
Only one (7.69%) out of thirteen cases had positive ER (treated with letrozole), and another patient (7.69%) had HER2-positive status and received trastuzumab for one year.
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PMC11335267
Spectroscopic data were acquired using 2018 points and 7.5 kHz spectral width.
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PMC11459296
The functionality of the engrafted CB-derived human immune cells, including increased activation markers, cytokine secretion, and T and NK cell degranulation, was validated ex vivo.
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PMC11791478
All doses were well tolerated with no measurable body weight loss.
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PMC11725127
Molecular docking simulations further revealed a potential allosteric pocket for GA binding to USP2.
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PMC11754432
Similarly, EGFR expression was increased in cells treated with control or ALOX15B siRNA followed by CDDO-Im at both, RNA and protein level (Fig. 6C, D).
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PMC9429973
Tokyo; Saitama Medical University International Medical Center, Saitama; Jichi Medical University Hospital; Dokkyo Medical University Hospital, Tochigi, Japan Background: Romiplostim, a thrombopoietin (TPO) mimetic protein, has been shown to promote tri-lineage hematopoiesis in patients with acquired aplastic anemia (AA) refractory to immunosuppressive therapy (IST) or eltrombopag; however, its effectiveness in the combination therapy with antithymocyte globulin (ATG) plus cyclosporine (CsA) as a first-line treatment remains unknown.
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PMC10932641
We present this article in accordance with the ARRIVE and MDAR reporting checklists (available at https://tau.amegroups.com/article/view/10.21037/tau-23-624/rc).
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PMC11394730
Oxidative and nitrosative stress happens when the quantity of ROS and RNS exceeds the antioxidant systems’ capacity.
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PMC6835428
In vitro, the PEG–PEI–FSH–sigro reduced the target mRNA level down to 47.3% of that of the control.
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PMC11371627
We hence wondered whether the location of the reported deletion correlates with specific clinical symptoms and if pathogenic changes in close proximity to the herein identified novel deletion might show clinical resemblance.
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PMC5535901
While PMA, a phorbol ester, directly activates protein kinase C theta (PKCθ) , ionomycin can promote T-cell activation through the increase of intracellular Ca .
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PMC11737091
Additionally, to further investigate the relationships between DBF4 expression levels and clinical characteristics, we evaluated differences in DBF4 expression across clinical stages genders, and age groups.
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PMC11659921
The correlation between TNFSF11 and immune checkpoint‐related genes was meticulously investigated.
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PMC10747160
Due to the threat of even mild forms of COVID-19 leading to breakthrough infections that could eventually yield fatal respiratory dysfunction, there is still a need to explore broad-spectrum prophylactic options to combat SARS-CoV-2 entry and infection .
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PMC9918897
The inoculated tumors were removed from the affected legs, scaled and immediately stored in 4% buffered formalin solution.
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PMC9813422
Due to the fact that HBV infection can result in liver cirrhosis, liver failure, hepatocellular carcinoma, and even death, it is considered one of the top 20 causes of human mortality (12).
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PMC11365427
Diluted siRNAs and diluted Lipofectamine RNAiMAX were added to the cells.
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PMC9429973
See firgure 1.
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PMC10652261
WST-1 assay was performed to test the cytotoxic effects of compounds 2a–l on HL-60 human acute promyelocytic leukemia (APL), K562 human CML, and THP-1 human acute monocytic leukemia cells (Table 1).
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PMC5839394
Spots of interest were manually picked and mass spectrometric sequencing was carried out after in-gel digestion, using sequencing-grade trypsin (20 μg/vial), according to the method of Shevchenko et al. with some modifications as already described .
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PMC7215832
PCFT is one of the three major cellular membrane folate transporters, in addition to the reduced folate carrier (RFC) and the folate receptor (FR) α .
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PMC2777936
In searching for therapeutic targets of the Wnt signalling pathway, the G-protein coupled receptor (GPCR)-like Frizzled 5 (FZD5) and Frizzled 7 (FZD7) were chosen for further analyses.
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PMC6643347
As demonstrated in Fig. 1, the IC50 values for the pseudoviruses Q769.d22, WITO4160.33, CE1176_A3, 703357.c02, and BJOX002000.03.2 fall within the ranges 0.62–0.75, 0.49–0.55, 0.95–1.13, 0.91–0.98, and 0.99–1.19 μg/ml, respectively.
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PMC11684297
This can be due to the leaky vasculature of cancer cells, which allows the nanoflowers to enter the cells and elicit cell killing, whereas the normal fibroblasts possessing intact cell membranes did not allow the nanoflowers to enter inside the cells.
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PMC11792888
The experiments were performed three times with three technical replicates each time.
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PMC10093184
For quantification of miRNAs, 200 ng total RNA was used for miRNA polyadenylation and reverse transcription with the MystiCq microRNA cDNA Synthesis Mix (Sigma-Aldrich).
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PMC11770130
RNA-seq analysis of WATs further revealed that the depletion of Ntsr2 downregulated the expression of genes related to UPR in WATs (Supplementary information, Fig. S6c and Table S9).
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PMC11622247
The excitation maxima of AF488 are blue-shifted by 15–20 nm relative to TO and TOtric.
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PMC11777207
After 4 hours, the medium from the bottom well was removed and spun, and the cells were counted using a hemocytometer.
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PMC11185260
Gray boxes indicate the treatment period. *
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PMC11680391
All dairy farmers and herd veterinarians approved the data collection of the questionnaire data and the publishing of anonymous results from the research project.
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PMC11733919
Different amounts of 17-AAG or 17-DMAG were added to the MNP@CD26 (MNP@CD26@17A and MNP@CD26@17D, respectively), finding that high amounts of both drugs (60 nmol/0.1 mg of Fe) led to the irreversible aggregation of the MNPs.
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PMC11626627
Subsequently, we performed chromatin immunoprecipitation (ChIP) assays in 786-O cells and found that TWIST1 could specifically bind to this site, and its binding was enhanced upon TWIST1 overexpression (Fig. 5B).
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PMC10812665
Such a different pattern of metabolic re-routing suggests other main targets of these toxicants.
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PMC11283030
Acetyl-CoA, the product of ACLY, could facilitate histone acetylation and chromatin accessibility, thus bolster T-cell effector function and potentiate antitumor immunity in cancers .
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PMC11720107
Large differences in polyphenolic levels have previously been reported in endemic Italian garlic cultivars (Schiacciato, Bianco, Torella, Salomone, and Ufita), even when grown on the same test field .
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PMC9429973
Besides, AA genotype of THPO rs956732 is also significantly increased in non-responders (AA/AG: OR=7.467, 95%CI=1.400-39.836).
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PMC5925824
Panel c: Tetanus toxoid recall assay: Supernatants were measured for IFN-γ production by ELISA.
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PMC11271278
The HiChIP data and the ecDNA segments in COLO320DM were published by ref. .
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PMC11767725
Notably, LL-37 levels inversely correlate with HDL cholesterol while positively associating with triglycerides, highlighting its potential role in atherogenic dyslipidemia.
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PMC11335267
Together, our data strongly suggest that the observed phenotype of Alx3-deficient mice is of central origin reflecting hypothalamic dysfunction.
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PMC11763111
Moreover, CD38 knockdown has shown to enhance the functionality of CD19 CAR-T cells and improves tumor responsiveness .
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PMC9429973
The patients were divided into two subgroups by defining NLR=2.0 as the cut-off point.
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PMC11049548
The metabolites of the growth media were grouped into two types: those that are released into the medium during cellular growth and those that are taken up from it.
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PMC11473843
We found that cancer cells resistant to FAK inhibitors evidence enhanced ERK5-FAK signaling dampening DNA damage.
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PMC11739504
Among the transfected cells, the tagged Kat2b was classified according to whether it was located in the cytosol, centrosome, and basal body.
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PMC11476264
Tumor cell invasion and metastasis are closely linked to epithelial-to-mesenchymal transition (EMT).
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PMC9429973
Targeting of the surface antigen CD123 expressed on both leukemic blasts and stem cells (LSCs) of most patients allows for depletion of both compartments, which is considered a prerequisite for deep anti-tumor responses and induction of prolonged remission.
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PMC11381192
Nomogram for predicting 2‐, 3‐ and 5‐year OS probabilities. (
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PMC11792888
Furthermore, upon crude venom fractioning through RP-HPLC, we found two soluble fractions with high cytotoxic effects.
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PMC11795610
In summary, these findings suggested that myricetin could promote keratinocytes differentiation and have well-established skin barrier protective function.
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PMC10588957
Statistical significance was set at P < 0.05.
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PMC11765243
Furthermore, p110α-deficient Tfh cells differentiated in vitro showed enhanced cytokine secretion but impaired motility, and Treg differentiation was inhibited .
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PMC11725127
Then, covalent docking was performed to explore the binding mode of GA to USP2.
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PMC11742047
Cross-validation was used to validate the models (p CV-ANOVA OPLS-DA = 1.63 × 10, p CV-ANOVA OPLS-DA = 1.19 × 10, respectively).
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PMC9516401
Cepa, and HACE in Caco-2 cells was 1950, 204.2, 457.2, 1239, and 110.69 µg/ml, respectively.
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PMC11525028
Red square indicated siNAT10. (
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PMC11463018
In flow cytometry assay, 85.3% induction of RPMI-8226 cells apoptosis incubation with 1 μM of 19 was significantly higher than that of SAHA (62.2%) and Filgotinib (15.28%) at the same concentration (Figure 5). (
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PMC7305184
First control (CTRL group) represents intact parental cell line, cells that were never exposed to pulse treatment.
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PMC7351993
Finally, the sort/unsort decision result with the corresponding cell ID is sent from the IA node to the TM node via the UDP communication.
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PMC11585254
The adjusted P values were greater than 0.05 (P > 0.05) for all receptor variants EC50 values relative to WT receptor except for the Dis variant (P < 0.01) in panel B. The Emax for the Dis (P < 0.01) and Med (P < 0.01) variants were found to be significantly different from WT for panel B; in panel C just the Dis receptor (P < 0.01) was significantly different.
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PMC9429973
A 3 + 3 design was utilized with Ven with dose levels 0, 1, 2 receiving 100mg, 200mg, and 400mg respectively.
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