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OTAR3088
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BioData-CellLine_annotated

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PMC11767725
Fungal diversity, measured via Shannon and Pielou indices, significantly increased at T8 (Shannon index: 2.66 ± 0.99 vs. T0: 1.37 ± 0.07; p < 0.0001), accompanied by a reduction in Malassezia relative abundance (74.8% at T8 vs. 96.5% at T0; p < 0.0001).
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PMC11437637
All patients underwent comprehensive staging surgery, and tissues, including the uterus, fallopian tube, and ovary were pathologically examined and staged based on the FIGO staging system (2009 edition).
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PMC11155445
The compound was characterized by NMR and single-crystal XRD.
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PMC10158546
Lentivirus-containing media (20 mL) was collected from the 150 mm dish at 48 and 72 h following transfection and cleared by centrifuging at 1,000 ×g for 15 min.
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PMC11544122
b CXCR4 endocytosis was examined in matched parental HEK293 cells or monoclonal CRISPR/Cas9 gene edited SNX9 knock out HEK293 cell line SNX9 KO #2.
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PMC10818573
The remaining reagents were the same as those used in the basic RPA system, and the reaction was performed at 39 °C for 20 min.
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PMC11769522
Therefore, future studies using different methods to analyze cytokine concentrations need to be conducted.
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PMC9429973
Of the 444 patients with NAB and immune cell fraction data available.
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PMC11468365
For used relation tasks, only the is minimized from the default model by 4.3% and 1.11% for synergy and sensitivity scores respectively.
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PMC7709199
For IL-12B, the crystals were cryoprotected in mother liquor and vitrified in liquid nitrogen.
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PMC10713411
A–E) Uni- and multi-Cox regression analyses based on the OS; a nomogram model on patients’ 3-/5-/7-year survival probability; ROC curves presenting model’s predictive accuracy; calibration curves and DCA curves over 3-/5-/7-year OS probability in E-MTAB-1980 dataset. (
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PMC11782508
Phylogenetic tree construction was performed using the Maximum Likelihood method in bootstrapping (1000 replicates) implemented in the MEGA software (Version 11.0).
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PMC7351993
The basic operation of the RIACS is as follows: suspended cells in a sample tube injected into the RIACS are focused by the hydrodynamic and acoustic focusers into a single stream, detected by the event detector, imaged by the SRS microscope, analyzed by the real-time Raman image processor, and sorted into a collection or waste tube by the dual-membrane push-pull cell sorter triggered by decision signals generated by the image processor.
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PMC8567602
C, HEK293 cells transfected with HA-SS18, HA-SS18–SSX, V5-SS18, or V5-SS18–SSX, followed by tag-IP or SMARCB1-IP and WB for each. (
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PMC11490153
Primers were acquired from Bioneer (Korea).
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PMC11321678
This method classified MB samples into 4 common subgroups with a limited number of genes.
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PMC9739791
Interestingly, the toxicity of the Pt(IV) prodrug 13 increased only slightly after irradiation, which indicates a crucial impact of nucleus-targeting R8K peptide axial ligand in enhancing Coumaplatin 14 cytotoxicity.
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PMC11506670
No. C3100MP; Thermo Fisher Scientific, Waltham, MA, USA) and 10 µM of DAPI per well was added.
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PMC11718031
Fig. 1Overview of the experimental design for screening (Part 1) basal media by batch cultivation and (Part 2) different basal media-feed combinations for fed-batch cultivation.
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PMC10547921
Tubulin is the composition of microtubules, and tubulin inhibitors interfere with the dynamic combination of microtubules by binding to tubulin, arresting cells in the G2/M phase of the cell cycle, and ultimately leading to apoptosis.
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PMC11295144
p < 0.05).
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PMC10654497
However, the role of SLC genes in the regulation of ferroptosis in patients with cancer and how it affects patient response to immunotherapy have not yet been investigated.
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PMC11648299
E-cadherin mediates cell-cell adhesion, and it has been shown in DD, that E-cadherin expression is absent or poor at the periphery of the acantholytic cells which leads to proteolytic destruction .
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PMC11352746
Degraded neurites (as determined by visual inspection) are not clearly distinguished from intact neurites, as the NeuroTrack mask often tends to count the area or branching points of evidently degraded neurites, making this analysis sometimes unreliable in neurite degeneration experiments.
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PMC11190538
This compatibility and incompatibility may be due to a disparity in the structure of both viruses or S. platensis extracts since the present study was also conducted on human coronavirus 229E, which has an RNA genome, whereas Hayashi et al. studied herpes virus, which has a DNA genome.
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PMC11363012
The iridoid secologanin (2) is found in high concentrations across a larger fraction of sampled leaf cells, highlighting the capacity of the plant cell factory to produce and store exceptionally high levels of a range of complex natural products.
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PMC9429973
In cohort 1, 30 patients were enrolled; median age was 40 years, 53% had ECOG PS 0, and 80% had no more than 3 prior lines of therapy.
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PMC11699042
Despite some of these strains had an undefined number of passages, they were considered serviceable for cell biology research.
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PMC9964654
The micelles studied herein exhibited hydrodynamic diameters within this range.
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PMC6133382
A glycoprotein sample (approximately 100 μg) suspended in 50 mM ammonium bicarbonate buffer was incubated with trypsin (5 μg, Sigma Aldrich) for 18 hours at 37 °C.
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PMC9884169
The RNA-seq analysis of the knockdown of the MCT4 group and the control group at the same time showed that a large number of ferroptosis-related genes were significantly changed after the knockdown of MCT4.
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PMC9429973
In the analysis population (n = 195), patients and CLL characteristics at baseline were: median age 74.0 years (33.0-91.0), male 68.2%, ECOG ≥2 18.5%, ≥1 comorbidities 87.7%, median time since diagnosis 8.3 years (0.0-29.4), 37.3% of 169 genetic examinations was TP53 and/ or del (17)p, median number of previous treatments 2 (1-9) (chemoimmunotherapy 87.2%, BCR inhibitors (ibrutinib, idelalisib) 70.8%).
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PMC11519567
Cells were permeabilized with 0.1% Triton X-100 and stained with DAPI.
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PMC11767725
Probiotics are particularly valuable in modulating the immune system and restoring microbial equilibrium.
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PMC11674834
3,4-DMA generated γ-H2AΧ in a concentration-dependent manner in each of the CHO cell lines.
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PMC11013014
The human HCT-116 colorectal carcinoma cells were cultured in Gibco McCoy’s 5A with 10% fetal calf serum (FCS) and 1% glutamine, while HL60 myelogenous leukaemia cells were cultivated in RPMI 1640 supplemented with 10% FCS and 1% glutamine.
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PMC11748363
Results were expressed as MIC compared to standards of gentamicin (GNT) and ciprofloxacin (CIP).
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PMC11394227
The CHO-PAb-QS-a5 and CHO-PAb-QS-b3 cell lines loaded more functional genes than CHO-PAb, resulting in a slightly slower proliferation rate.
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PMC10887351
Moreover, ADRB3 gene mutations were associated with an increased risk of obesity and diabetes, insulin resistance and nonalcoholic fatty liver disease in the obese condition .
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PMC6835762
The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs).
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PMC11687663
Since the plant collection site was open to public, permission from the municipality was not required.
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PMC9351137
These findings suggest that some CRS retain their physical interactions across cell cycle progression and relocate as sub-complexes.
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PMC11787651
Given the broad range of processes that involve histones, it is no surprise that there are hundreds of annotated PTMs across multiple histone isoforms, creating what is termed the “histone code” (8, 9).
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PMC11766309
In ACC, CESC, ESCA, GBM, HNSC, LUAD, LUSC, SKCM, STAD, TGCT, THCA, THYM, UCEC, and UCS, YKT6 expression was inversely correlated with the immune score (Figure 7B).
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PMC8009078
3The binding interaction of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2Fig.
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PMC11577421
NP_BSA and NP_FBS (1 nM) were titrated with heparin in PBS buffer.
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PMC11720808
P < 0.01 compared with the wild-type 143B cells. (
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PMC11578343
Error bars in (B, iii) correspond to standard error.
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PMC9429973
We also observed robust DNA methylation changes at the promoters of other lineage-specifying genes including TBX3, TBX5, PITX2, NR2F2, and EN1.
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PMC2118063
Western blot analyses of IRF8 and α-tubulin expression in NFS-202 cells expressing a negative siRNA and clones expressing either suppressive siRNA #2 or #5. (
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PMC9985266
β-Actin was used as a control.
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PMC11806818
The cell sensor can be regenerated by simply pulling out the magnet.
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PMC4685411
To approve this concept, a two-step growth process with media exchange followed by a fed-batch with an optimized feeding profile was designed using DoE tools in silico.
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PMC9429973
It has been described that lenalidomide inhibits CDC25A selectively in the del(5q) clone resulting in G2/M arrest and apoptosis.
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PMC9429973
Improvements in anemia, markers of hemolysis, oxygen affinity, 2,3-DPG level and ATP/2,3-DPG ratio were seen.
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PMC11770746
Creatinine measurements and histopathological analyses (Supporting Information), whereby toxic changes to the tubules were associated with focal tubular necrosis in cisplatin samples but not in cisPt(Pac)(OH), suggest lower kidney toxicity for cisPt(Pac)(OH) compared with cisplatin.
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PMC10218459
The fluorescence signal of the cells was measured 2 h after treatment, and the formation of resorufin in living cells was detected using a multimode plate reader at 560Ex/590Em (TECAN, Männedorf, Switzerland).
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PMC11742231
With a more comprehensive understanding of the molecular profile of a patient’s cancer, doctors can determine the most effective treatment regimen, which is essential for precision medicine.
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PMC11588008
Analysis of surface markers on HUC-MSCs by flow cytometry.
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PMC11727907
from Cell Signaling Technology, Beverly, MA, USA.
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PMC11627398
Real time PCR was conducted with the ArtiCanATM SYBR qPCR Mix kit (No. TSE501, Beijing Tsingke Biotech Co., Ltd.) on a fluorescence quantitative PCR instrument (QuantStudio 5, Life Technologies).
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PMC11767817
The assembly and catalytic activity of cyclin/CDK complexes are regulated by CDK inhibitors (CDKIs), which can block cyclin–CDK complex activity and prevent cell cycle progression.
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PMC11634027
We expressed the ICDs of Ds motif deletion constructs in cultured Drosophila S2 cells, together with FLAG-tagged Lft.
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PMC9429973
There was no statistical difference in OS when comparing CPX-351 to FLAG-IDA and 3 + 7 (p=0.855) (Figure 1).
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PMC11799620
To each tube, 50 µl of 0.07 M ferrous sulfate (in 0.1 M PBS) was added.
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PMC9429973
Descriptive analysis showed that the bacterial colony counts of cuff, abdomen and front chest at the 6th hour after changing clean uniforms were (11.30±3.56) CFU/cm, (8.79±2.33) CFU/cm, and (11.06±2.71)CFU/cm and the qualified rates of cleanliness were 0, 9.1% and 3.0% respectively.
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PMC11354239
Notably, the mean fluorescence intensity (MFI) corresponding to the intensity of the TNFα signal was increased upon incubation with RTX-coated Raji in the responder’s population almost four times compared to non-responders (Figure 5C).
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PMC10170482
To thoroughly characterize the collagen scaffold microstructure in a liquid environment, we utilized the ColF fluorescent probe (Immuno Chemistry Technologies, Davis, CA, USA).
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PMC11612508
The cells were placed into 96-well culture plates at 3 × 10 cells per well and incubated in 5% CO2 at 37◦C for a day.
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PMC11279397
Furthermore, some viruses can induce chronic infectious conditions such as human immunodeficiency virus (HIV) , hepatitis B virus (HBV) , and hepatitis C virus (HCV) .
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PMC11721096
As indicated in Figure 3B, 30 min of incubation was enough to bind the ligand, while the remaining enzymatic activity decreased when the incubation time was above 90 min.
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PMC9429973
We observed a trend increasing (different types of donations over time): HR=0.38, p=.000 (S).
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PMC8345486
To assess whether the differences in the cytotoxicity of metallacarborane-modified adenine nucleoside are related to disturbances in cellular homeostasis, we analyzed the specific induction of various types of cell death.
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PMC11783017
IL11Rα expression in tumor and normal cells. (
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PMC9910796
Briefly, Vero cells were transfected with plasmid pEP84Ri and infected with BA71V virus in the presence of 1mM isopropyl-ß-D-thiogalactopyranoside (IPTG).
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PMC11758416
Adjust the concentration to 1E5 L cells per mL.c.
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PMC8358176
There was also no significant change in the gene expression levels of TNF and TNFRSF10A in CNT-treated rats after 30 and 60 days.
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PMC11657744
Synthetic siRNA oligonucleotides were obtained from Life Technologies Corporation.
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PMC11612508
Scanning electron microscopy (SEM) images were conducted using the TESCAN MIRA 3 device.
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PMC10391797
The data of mice leukemia burden are represented with the color scale bars indicating maximum and minimum bioluminescence (BLI) thresholds at different time points. (
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PMC9386809
The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies.
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PMC8345486
The reference compound, 2′-O-propyloadenosine (25), no-metal-ion-containing conjugate of adenosine and nido-7,8-dicarbaundekaborate ion, was synthesized and used as counterpart of the most active metallacarborane derivatives.
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PMC10204952
However, the cellular concentration of S1P is normally in the low nanomolar range, and our previous studies showed that S1P selectively induced apoptosis of breast cancer cells at high concentrations (high nanomolar to low micromolar).
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PMC11349530
Some phase I and II trials showed disease stabilization in various malignancies, and the phase Ib trial (NCT03293784) combining TNF inhibitor certolizumab with anti-PD-1/anti-CTLA-4 in melanoma patients demonstrated safety and high response rates (58, 102).
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PMC10507284
Association of TROAP with tumor immunity in STS. (
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PMC11594588
Inducing processes related to lipid peroxidation, in which DNA bases are modified and etheno and propano derivatives are formed leads to a disturbance in carbohydrate metabolism in the body .
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PMC10317042
B, Genome browser screenshot of the epigenome maps at EWSR1.
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PMC11718109
Moreover, DA neurons have an innate ability to fire in two patterns: tonic (4–5 Hz) and bursting (~20 Hz) phases.
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PMC11621565
The continuous increase in cell index in the proliferative SH-SY5Y cells reflects cell proliferation.
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PMC11638255
Cells were then clustered via the Louvain algorithm, with a resolution of 0.3.
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PMC9895440
Based on the individual gene KO data, we decided to further investigate SNX9.
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PMC9351137
Three independent experiments were performed.
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PMC10878518
The tumor specimens of the primary bone and soft-tissue tumor were obtained from 68 patients who underwent surgery at Okayama University Hospital between January 2015 and July 2016.
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PMC11206251
The cells were collected by centrifugation, resuspended in PBS, and inoculated in 6-well plates at 1 × 10/well in a cell incubator for 24 h. The old medium was discarded, and different concentrations (50 μg·mL, 25 μg·mL, and 12.5 μg·mL) of drugs were added for intervention.
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PMC9844987
Therefore, a feature is considered relevant only if its score is higher than the best randomized feature.
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PMC9429973
Variables of importance were analyzed using descriptive and analytical statistics.
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PMC11803149
Alignment files were processed using Samtools (v1.12).
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PMC11641532
Genes from cluster 5 were extracted and integrated with bulk RNA-seq data, identifying 3 beta-hydroxy steroid dehydrogenase type 7 (HSD3B7) as a critical gene involved in tumorigenesis for further research.
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PMC11519583
In contrast, the expression of Wnt5b, which encodes the closest relative of Wnt5a, was markedly increased in glycerol-, but not Ctx-, injected TA muscles (Fig. 3b, right panel).
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PMC9927933
Given that DEPTOR knockdown rescued the phenotypes induced by UBE2C knockdown in in vitro cell culture models, we then determined in vivo whether Deptor KO could rescue the suppression of lung tumorigenesis by Ube2c KO in the Kras mouse lung cancer model.
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