text stringlengths 0 868k |
|---|
Langerhans cell histiocytosis (lch) is a rare monoclonal disease, of which incidence rate is 4 to 5 per 1 million individuals, and mortality rate is about 3% in adults . Its clinical presentation is highly variable because it can affect multiple organs, such as lung, bone, skin, lymph nodes, hypothalamopituitary axis, ... |
It explains why the flowers of some orchids have extraordinarily long spurs to store their nectar, and why the moths that pollinate them have extraordinarily long tongues to drink it . It explains why we don't all succumb to diseases, and why diseases still exist . How coevolution actually works is far from clear, howe... |
If medical radiation sciences is to evolve as an evidencebased profession, we must increase research productivity and publication in our field . The importance of research collaboration has been recognised and strongly supported by research organisations and policy makers alike1 and there has been a marked rise in inte... |
Maintenance of blood glucose levels as close as possible to the nondiabetic range over time is an important goal in the current management of patients with diabetes . Assessment of a patient's diabetes management can be accomplished by directly analyzing the pattern of multiple blood glucose samples drawn over time . H... |
Malaria remains a major cause of mortality and morbidity especially in sub - saharan africa . Children under five and pregnant women remain the most vulnerable groups afflicted by this disease . Control programs are strongly affected by resistance to insecticides and to antimalarials, including the recently implemented... |
There are well over 50,000 commercial ships which move goods around the world among over 300 major ports . However, the ballast water associated with merchant vessel traffic is also responsible for the transfer and introduction of aquatic invasive species to coastal waters where they can cause enormous ecological and e... |
Cancer cachexia occurs most frequently in malignancy and is associated with more than 20% of cancer deaths . Patients with upper gastrointestinal cancer are especially likely to suffer from substantial weight loss, and patients with pancreatic cancer have the highest frequency of developing a cachectic syndrome . Thus ... |
A number of methods of reconstruction have evolved over a short period.12345678910111213141516171819202122232425 a majority of described techniques use either implants or bone tunnels for fixation of the mpfl graft . It has now been widely accepted that the reconstruction needs to be anatomical, both at the femoral and... |
Antiretroviral therapy (art) has brought important benefits to hiv - infected patients, such as increased survival, better quality of life, significant reduction in the incidence of opportunistic infections and lower costs related to ambulatory care and hospitalization.1,2,3 the brazilian national std / aids program of... |
The influence of diet on human health has been studied for a long time . In the fourth century bc, hippocrates already stated: let food be your medicine and medicine be your food . This theory was again recalled in the nineteenth century thanks to ludwig feuerbach who wrote man is what he eats . Today recent studies ha... |
Throughout the world, especially in developing countries, the incidence of lung cancer is on the rise . In the united states, the last decade has seen an increased availability of techniques to aid screening, early diagnosis and targeted treatment of all forms of lung cancer, despite which the incidence continues to ri... |
The article " efficacy of and tolerance to mild induced hypothermia after out - of - hospital cardiac arrest using an endovascular cooling system " by pichon et al . In the previous issue of critical care only 10% of patients undergoing out - of - hospital cardiopulmonary resuscitation are discharged alive from the hos... |
Minimal change nephropathy (mcn) accounts for 25% of adults presenting with a nephrotic syndrome . Although most patients respond to corticosteroid therapy, a significant number relapse frequently and may present a real therapeutic difficulty . We present a case of apparently refractory relapsing mcn that was successfu... |
Dysthymic disorder (dysthymia) is a disabling psychiatric disorder characterized by mild but persistent depressive symptoms . In the usa, it is reported that the lifetime prevalence of dysthymia ranges from 3% to 6% in the general population,1,2 and up to 36% in psychiatric outpatient clinics.3 in japan, a low lifetime... |
The incidence of autoimmune diseases (aids) such as systemic lupus erythematosus (sle), rheumatoid arthritis, and primary biliary cirrhosis (pbc) has been increasing in china . Until now, the antinuclear antibody (ana) test, wherein antibodies are detected by indirect immunofluorescence assay on hep-2 cells, is commonl... |
For repeated administration of chemotherapeutic agents, intravenous hydration, or parenteral nutrition to cancer patients or chronically ill patients, the role of the totally implantable central venous port (ticvp) system is greatly increasing to address concerns about quality of life . Annually, more than 5 million ce... |
Miliary mottling consists of opacities, between 0.5 to 2 mm in size, in chest radiography . In indian settings, although miliary mottling is more commonly associated with miliary tuberculosis, it can be seen in other conditions such as fungal infections (histoplasmosis, coccidioidomycosis, cryptococcosis, and blastomyc... |
Proteins assemble into dynamic macromolecular complexes that regulate fundamental cellular processes such as cell cycle progression and mitosis . Affinity purification coupled to tandem mass spectrometry (ap - ms) has been used extensively to decipher the composition of protein complexes and their networks involved in ... |
During adolescence, children undergo rapid physical, mental, and emotional changes, and thus become prone to risk - taking behaviors such as voluntary poisonings . Voluntary poisoning has been defined by the world health organization multicenter study on parasuicide as an act with a nonfatal outcome in which an individ... |
Immune hemolysis is a shortening of red blood cell survival due, directly or indirectly to antibodies . It is necessary to identify these atypical antibodies in the patient s serum in order to select appropriate blood for transfusion . Even in the most vexing situation encountered by a transfusion specialist where no c... |
Characterization of the carotid flow waveform is important as its contour determines regional shear stress, a strong determinant of atherosclerosis, and its pulsatility contributes to cerebral damage [13]. The carotid flow velocity waveform in healthy human arteries is unidirectional (predominantly antegrade) and triph... |
A 43-year - old woman diagnosed with intravenous leiomyomatosis at another hospital was transferred to our hospital . She had suffered from palpitation, dizziness, dyspnea, and chest pain for two weeks prior to admission into another hospital, and had experienced syncope three times on the day of admission to our hospi... |
Discovery of carbon nanoparticle (np) in 1980s was perhaps most important discovery of the last century . It was observed quite early that there is a radical alteration of physical and chemical properties of matter when it exists at nanoscale . Manmade nps range from the well - established multi - ton production of car... |
The broad mite, polyphagotarsonemus latus (banks) (acari: tarsonemidae), is a serious pest of several greenhouse crops worldwide, including pepper, cucumber and egg plants (gerson 1992; palevsky et al . Because of their small size (0.10.3 mm long), broad mites are not initially noticed in crops, but are detected when p... |
We identified 648,276 individuals in the swedish medical birth register who were born from 1973 through 1979 . Of this total, we excluded 6,553 (1.0%) individuals who were no longer living in sweden at the time of follow - up (20052009), 7,926 (1.2%) who had significant congenital anomalies (i.e., other than undescende... |
Medical emergency teams (mets) and critical care outreach are no longer new ideas . The services were founded in australia in the 1990s with the concept of mets using the well - recognised principle that early recognition and aggressive intervention improves outcome from critical illness . The systems have now develope... |
It is rare for an acute myocardial infarction (ami) to occur without angiographic evidence of atherosclerosis . Possible mechanisms for such an event include coronary artery spasm, coronary embolism from an intracardiac or paradoxical (venous) source, thrombosis caused by hypercoagulable states, and inflammation in res... |
Ameloblastoma is a rare tumour of odontogenic epithelial origin, which accounts for approximately 1% of all mandibular tumours and cysts [1 - 2]. It has high propensity for local recurrence if not adequately removed and although the tumour may appear microscopically benign, the development of distant metastasis is poss... |
The extrapolymeric substance (eps) produced by bacillus subtilis and bacillus licheniformis have carbohydrate components as in levan (fructan) or peptide component as in gamma polyglutamic acid (pga) [15]. Although pga - producing bacillus isolates have been reported many of these produced exopolysaccharide also . Extr... |
Although the prevalence of metastases to the thyroid gland is variable in previous reports, metastasis to the thyroid gland is known to be an uncommon condition . Fourteen cases of metastatic tumor to the primary thyroid carcinoma have been reported previously in the literature . The majority of reported primary thyroi... |
Giant cell tumor (gct) of bone is a relatively common benign bone lesion . Gcts are usually located in long bones, and most lesions are found around the knee . Although gcts have been observed in other less frequent sites, such as the patella, great trochanter, and skull; involvement of the olecranon we present a case ... |
Human capital and health improvement programmes are of central importance towards sustainable development and economic growth in any country . In malaysia, the health care system has changed from traditional remedies to meeting the emerging needs of the population . Since the independence of malaysia in 1957, the first... |
Physical activity refers to any movement produced by skeletal muscles that results in energy expenditure, and can be measured quantitatively using metabolic equivalents or step - counts (9). As such, physical activity is an encompassing term that includes exercise, training, participating in sport, active play and acti... |
Magnetization transfer (mt) imaging is a quantitative approach for detecting subtle or occult abnormalities in brain tissue . In previous studies, the magnetization transfer ratio (mtr), an index of mt imaging, was sensitive to brain changes in patients with mild cognitive impairment, an alzheimer's disease prodrome [1... |
Inflammatory mediators play a key role in acute pancreatitis development and in the systemic complications of the disease, which are a main cause of patient's death . One of the most important mediators of inflammation is interleukin-6 (il-6), which can be considered as a factor modulating the defence mechanism in orga... |
One of the common predicaments experienced by patients undergoing tooth preparation and cementation on vital tooth for crown and bridge restorations is dentinal hypersensitivity.1 the phenomenon of dentinal hypersensitivity is best explained by brannstroms hydrodynamic theory, which states that when exposed, dentinal t... |
The two hemispheres of the human brain are not equivalent . Relative functional differences between the left and the right side of the brain, so - called functional hemispheric asymmetries, have been observed for several cognitive functions (corballis, 2009). For example, most individuals show a right - hemispheric dom... |
The 2 huvec cell lines used in the study were derived from male caucasian donors genotyped as heterozygotes for the 9p21 cad associated snps . The 4 ebv transformed lymphoblastoid cell lines (lcl) were selected for their genotypes (2 homozygous cad risk or 2 homozygous cad non - risk) using the hapmap data27 . Experime... |
This assistant could be taught the uses of the appropriate pills for the treatment of the major fevers, dysentery and high altitude headaches . Besides assisting the party home, it would slowly diminish the deep - rooted superstitions that exist in the home villages, wrote new zealand mountaineer norman hardie in his a... |
Eosinophilic chronic rhinosinusitis (ecrs) has been established as a subtype of chronic rhinosinusitis (crs). It is characterized by a resistance to conventional treatment with long - term macrolides, and frequent recurrences develop unless treated by steroids.13 ecrs is common in asians . To make a diagnosis, the foll... |
Dens invaginatus (di) is a developmental anomaly that results in a deepening or invagination of the enamel organ into the dental papilla prior to calcification of the dental tissues . This type of malformation was first described by ploquet in 1794 in a whale's tooth . Di was first described as a tooth within a tooth b... |
Malaria is a major public health problem in tanzania causing an enormous burden to health and economy . In this country, over 95% of the 38 million people are at risk for malaria infection . The disease is responsible for more than one - third of deaths among children under the age of 5 years and for up to one - fifth ... |
Parkinson's disease (pd) is characterized by the selective degeneration of nigrostriatal dopaminergic (daergic) neurons, resulting in dopamine (da) depletion . While the etiology of pd is not completely clear, several pathology studies have demonstrated that, in postmortem samples of substantia nigra pars compacta (snp... |
The periodontal diseases are the most prevalent oral diseases worldwide especially in developing countries like india . General unawareness, infrequent dental visits, lower socioeconomic status, and illiteracy have contributed to its high prevalence . Gingivitis and periodontitis are chronic inflammatory disorders of p... |
Classical pcr - ligation strategy is the most familiar one to clone for its convenience and efficiency . In long cds cloning, pcr and sequencing are the most challenging steps . Dna is not easily amplified from complementary dna (cdna) for many reasons, e.g. Cdna may not be in good quality, primers are easier to miss -... |
Acute promyelocytic leukemia (apl), m3 subtype of acute myeloid leukemia (aml) is characterized in the majority of cases by proliferation of neoplastic hypergranlar promyelocytes and blast . The biological and clinical heterogenicity of apl is based on the clinical presentation of the disease and various characteristic... |
Decoy receptor 3 (dcr3) also referred to as tr6, m68, or tnfrsf6b is a family member of the tumor necrosis factor receptor (tnfr) superfamily . Dcr3 has been described in many malignant tumors, such as gastric, hepatocellular, colon, lung, cervical, ovarian, and breast cancer . A gastrointestinal cancer meta - analysis... |
Anthrax, a zoonotic disease caused by bacillus anthracis (b. anthracis), primarily affects herbivores including sheep, cattle, horses, and other domestic animals.1 humans may be affected as a result of exposure to an infected animal or animal products . This organism has received recent attention as a potential agent o... |
At present, selecting a type of prosthetic heart valve for surgical correction of acquired cardiac failure represents a topical issue for modern medicine . Biological or mechanical prosthetic heart valve are available options . In particular, xenogeneic tissue treated by fixatives and preserving solutions is applied in... |
Approximately 24 per cent of small bowel obstructions (sbos) are caused by bezoars . In addition, presentation with features of acute surgical abdomen is extremely rare, accounting for only 1% of the patients . A bezoar is a concretion of indigestible material found in the gastrointestinal tract, which usually forms in... |
There has been an increasing interest in pharmacokinetic (pk)/pharmacodynamic (pd) analyses because they are able to optimize dosing regimens, thereby improving outcomes.1 pk / pd analyses, based on the principle reported by craig2 and other researchers to optimize dose regimens for clinical applications, are now incre... |
Cystatin c is a 13.3kda protein, well known and commonly used in the clinic as a marker of kidney function.1 it is also involved in extracellular matrix remodeling2 and may be directly associated with the development of atherosclerotic cardiovascular disease (ascvd).3, 4 there is a wellestablished relation between chro... |
Concurrent tumors are a well - known entity, at times posing diagnostic and therapeutic difficulties . They can be synchronous, independently derived, nonmetastatic tumors, or metastatic tumors . Distinguishing between them involves clinicopathologic interpretation based on multiple criteria including histologic type a... |
Corneal neovascularization (cnv) is a sight - threatening condition that is encountered in various inflammatory settings including chemical injury . Cnv can lead to corneal scarring, edema, and lipid deposition that may compromise visual function and decrease the success rate of subsequent penetrating keratoplasty . To... |
Uncontrolled bleeding remains major challenge, responsible for 40% trauma - related deaths, which could be prevented by timely intervention . In blunt trauma, extent of hemorrhage cannot be determined by physical examination, as vital signs may not give a clear picture in all the patients, especially young healthy once... |
Spondyloarthritis (spa) is one of the most common chronic immune - mediated inflammatory diseases, affecting 0.5%1.5% of the western population . Spa comprises ankylosing spondylitis (as), psoriatic arthritis, arthritis / spondylitis with inflammatory bowel disease and reactive arthritis; patients with typical features... |
Cervical radiculopathy is typically caused by lateral disc herniation or osteophytes in the intervertebral foramen . Surgical management for radiculopathy of the cervical spine includes anterior cervical discectomy and fusion (acdf), cervical foraminotomy via an anterior or posterior approach, and cervical arthroplasty... |
Leishmania spp . Lives in the gastrointestinal tract of the sand fly vector, and can be cultured using appropriate laboratory culture media as promastigotes . They can also exist in the vertebrate host macrophages in the amastigote form (13). While asexual reproduction is known to occur in this species (4), their sexua... |
Darier's disease is an autosomal dominant disorder of keratinization affecting the skin, mucosa, and nails that typically manifests in the first and second decade of life . We describe an elderly man with nonmetastatic gastric adenocarcinoma presenting with an acquired variant of darier's disease presumably of paraneop... |
Malnutrition continues to be a significant public health and development concern . Across the world, in 2015, the numbers of stunted, overweight, and wasted children under five years old were about 159 million, 41 million, and 50 million, respectively.1 this burden is not evenly distributed: three - fourths of the worl... |
Academic failure is a serious problem of the students, educational system, and society . Usually the students who have experienced academic downfall during their education do nt demonstrate desired theoretical or practical capability of their lessons . Academic downfall can also result in numerous emotional, social, be... |
On september 15, 2009, a 29-year - old woman, 61 kg, 1.69 m stature, caucasian, with no comorbidities, post - graduated, brazilian, from recife - pe was submitted to an elective bilateral reductive mammoplasty on a private hospital of recife - pe to remove 200 ml of each breast using the l technique for resections of e... |
Laparoscopic cholecystectomy (lc) has been long established as a surgical procedure that typically is minimally invasive . However, lc can result in various kinds of surgical complications that are not commonly associated with open cholecystectomy . Bile duct injury is the most common lc - associated complication, with... |
The bone - anchored hearing aid (baha) is a bone - integrated implant that was introduced in clinical practice in sweden in the 1970s1 . It is a bone conduction hearing device that transmits sound directly into the inner ear, bypassing skin impedance and subcutaneous tissue . It has been used in patients with mixed or ... |
Over the past two decades many countries including new zealand have faced a shortage of medical practitioners willing to practice in rural areas [15]. This problem is compounded by general medical workforce shortages related to increasing demands from the combination of an ageing population and an ageing medical workfo... |
A 6-year - old, 25 kg boy was scheduled for strabismus surgery in both eyes . Neither the patient nor his family had any history of neuromuscular disease or a special family history . The preoperative vital signs were blood pressure: 90/50 mmhg, heart rate: 92 beats / min, respiratory rate: 24/min and axillary temperat... |
The us food and drug administration (fda) adverse event reporting system (faers, formerly aers) is a database that contains information on adverse event and medication error reports submitted to the fda 1 - 3 . Besides those from manufacturers the faers structure adheres to the international safety reporting guidance i... |
Lower frequency of sleep disturbances during the run - in period and absence of daytime and nighttime reflux symptoms during treatment were associated with a greater likelihood of resolution of reflux - related sleep disturbances in the total population.treatment with esomeprazole 20 mg was a significant predictor of s... |
Hydatid disease (hd), also known as cystic echinococcosis, is caused by infection with the larval stage of echinococcus granulosus . The disease has the highest incidence in countries where sheep are raised with the help of dogs . In endemic regions, human incidence rates for hd can reach> 50/100,000 person - years, an... |
However, cost, difficulty of implementation, and other barriers impede adoption of such systems, and studies have documented low rates of technology acquisition and implementation in emergency department (ed) and other settings . A study of residency - affiliated eds in 2000 found low rates of adoption, with only 7% re... |
, there is not agreement on the definition of emotion regulation, which has been inconsistently defined in the different studies . Emotion regulation has rooted in analytical psychology, stress and coping strategies (1). Some concepts of emotion regulation emphasize the ability to control emotional experience and expre... |
Stent thrombosis is a rare but fatal complication of drug eluting stent (des). Although dual antiplatelet therapy with aspirin and clopidogrel significantly reduced the occurrence of stent thrombosis, late stent thrombosis still occurs; many other factors could be attributable to the occurrence.1)2) of these, clopidogr... |
The incidence and prevalence of diabetes mellitus have significantly increased worldwide in recent decades, primarily due to the increase in type 2 diabetes mellitus (t2 dm). Long - term diabetes results in vascular changes and dysfunction, and diabetic vascular complications are the major cause of morbidity and mortal... |
Collected at 4 european centers, a total of 113 specimens from 105 patients were included in the present study . The material comprises 91 mpnsts, 21 neurofibromas, and 1 tumor - free sciatic nerve from a chondrosarcoma patient serving as a nonneoplastic nerve sheath control (supplementary table s1). All specimens have... |
Recently, serratia, pseudomonas / providencia, indole - positive proteus / acinetobacter / morganella, citrobacter, enterobacter and hafnia group of organisms (spice) were described to cause peritoneal dialysis (pd)-related peritonitis with a particularly high morbidity and mortality . Peritonitis caused by citrobacter... |
Recently, a group of small - molecule compounds have been identified as tyrosine receptor kinase (trk) receptor agonists that had profound pro - neuronal effects on neurogenesis and neuronal regeneration [14]. These compounds hold great clinical importance for neurodegenerative diseases as they may easily penetrate blo... |
Unilateral renal agenesis is a common associated urinary tract anomaly in high anorectal malformation . The remnant solitary functioning kidney with an intrinsic potential for hyperfiltration injury may also have varying degrees of congenital or acquired, structural, or functional affliction that compromise renal paren... |
The traditional medicine (trm) of korea and china share the same cultural heritage, and the two countries are taking central role within the world health organization western pacific regional office in terms of east asian trm . East asian trm employs acupuncture and herbal medicine as its major forms of treatment, and ... |
Bites from venomous snakes kill more people in the developing world than some of the world's better recognized and better studied neglected tropical diseases . . Though not all bites are by venomous snakes or result in poisoning, up to 2 million of these bites result in the injection of venom, with hundreds of thousand... |
Although great enthusiasm exists for developing skills in laparoscopic urology in the united kingdom, training opportunities are limited . This is primarily due to a lack of approved urology / laparoscopy fellowships, as exist in the united states . It is an unfortunate fact that many interested urologists do not progr... |
The worldwide incidence of strabismus varies from 3% to 5%,1,2 whereas hu and colleagues3 identified strabismus in 2% to 4% of white populations, and abrahamsson and colleagues4 reported strabismus in 0.6% of asians3 and africans.5 in a study conducted by dana and colleagues5 in sydney, the incidence of strabismus was ... |
Carbon monoxide poisoning is the fourth most common type of poisoning in china, and is a leading cause of neurological disturbances . The psychiatric and neurological symptoms of carbon monoxide poisoning include headache, muscle weakness, drowsiness, memory disturbances, apraxia, delirium, speech disorder, epileptic s... |
The concentration of ammonium is usually more than micromolar level in mostly continental water and coastal seawater, even up to millimolar level due to environmental pollution [24]. However, it is less than micromolar level, even down to nanomolar level in ocean water and some unpolluted freshwater [5, 6]. The accurat... |
This special issue of fungal genetics and biology describes a comprehensive effort to develop methods and expertise to tackle one of the world s most serious fungal diseases of wheat . The series of papers within this issue are designed to provide a resource for a new generation of plant pathologists who we hope will b... |
Numerous causes have been attributed to low back pain (lbp). A long list exists, but the enlistment of sacralization as one of the causes has resulted in a lot of controversy . Sacralization is a congenital vertebral anomaly of the lumbosacral spine (fusion between l5 and the first sacral segment). Several studies have... |
Sepsis has been classically considered the archetypal clinical condition with molecular links between inflammation and coagulation . Both inflammation and thrombosis can be orchestrated by the interactions between circulating cells, such as lymphocytes, platelets, and vascular cells, which under activation or apoptosis... |
Maxillary constriction can cause posterior crossbite, dental crowding, and abnormal muscular function . In the orthodontic field, maxillary expansion is performed to correct maxillary transverse constriction and the tooth axes of the posterior teeth, alleviate dental crowding, and establish a favorable maxillomandibula... |
The posts are commonly used to restore endodontically treated teeth when the remaining coronal tissue is insufficient or inadequate, to provide adequate support and retention for the restoration . The rationale of using dual cured resin cement is to have a material with extended working time, which is capable of polyme... |
About 50% of patients admitted to the intensive care unit (icu) have systemic inflammatory response syndrome (sirs). Of these, 30% have or eventually develop sepsis . Mortality rates in critically ill patients with sirs are high, ranging from 10% to 20% . . This will assist clinicians in reevaluation and intensificatio... |
Aplastic anemia is characterized by bone marrow failure and marked decrease in all marrow elements . In severe form of aplastic anemia, rapid bone marrow transplantation after primary workup is life saving; however, protected environment and prevention of opportunistic infections may be difficult in these cases . Gram ... |
Menopause is defined as generally cessation of periods for 12 months or a period equivalent to three previous cycles or as time of cessation of ovarian function resulting in permanent amenorrhea . It is a stage when the menstrual cycle stops for longer than 12 months, and there is a drop in the levels of estrogen and p... |
Obesity is the most frequent metabolic disease worldwide and can progressively lead to a spectrum of comorbidities, including type 2 diabetes, hypertension, dyslipidaemia, cardiovascular disease, liver dysfunction, and osteoarthritis [13]. Preventing obesity - related co - morbidity relies on effective weight loss inte... |
Adult - onset still's disease (aosd) is a rare inflammatory disease of unknown etiology, which commonly affects young adults . It is usually characterized by high spiking fevers, arthritis, and an evanescent, nonpruritic, macular and salmon coloured rash, appearing on the trunk and the extremities . Important laborator... |
Micropigs are considered as the optimal transplant donor animals because their organs have a similar anatomy and physiology to human organs . Therefore, the selection of the normal healthy micropigs and the survey of vessels supplying the organs for transplantation are important . However, there are no baseline studies... |
Plant traits such as leaf shape, trichomes, leaf surface waxbloom, and chemical compounds can affect the animals associated with the plant (hare 2002; whitham et al . Plant traits may affect both herbivores and predators, and interactions between predators and their prey may be altered to produce indirect ecological ef... |
Increasing evidence indicates that aberrant activation of the embryonic programme epithelial mesenchymal transition' (emt) promotes tumour cell invasion and metastasis (berx et al, 2007). Emt allows detachment of cells from each other and increases cell mobility, both of which are necessary for tumour cell disseminatio... |
The nuclear receptor corepressors were initially identified as nuclear proteins recruited by the thyroid hormone receptor (tr) and retinoic acid receptor (rar) isoforms to mediate ligand - independent repression . More recently, they have been shown to modulate the transcriptional activity of a wide variety of transcri... |
They are present in 10 to 55% of cases trotter, konarik, reaching 23% of cases in the free part of the limb - valsecchi . The brachial artery begins at the distal border of the tendon of the teres major muscle and ends close to the elbow joint . Frequently the brachial artery divides more proximally into radial, ulnar ... |
Neuroimaging studies have shown that patients with major depression display differences in the function and structure of brain regions involved in emotion identification and reactivity, including the amygdala, hippocampus, striatum, and orbitofrontal cortex, as well as areas involved in emotional regulation, such as do... |
High - throughput biochemical screens, used to identify pharmacologically active small - molecule compounds, are a staple of modern drug discovery . In these screens, hundreds of thousands to even millions of compounds are tested in highly automated assays . Although robotics and miniaturization have led to increased e... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.