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T - cell activation requires specific recognition of antigen presented as small fragments (peptides) bound to major histocompatibility complex (mhc) molecules . The recognition of a particular peptide - mhc occurs through a highly specific t - cell receptor (tcr), which is selected in the thymus . Following tcr trigger... |
Clonal proliferation of histiocytes was reported in langerhans cell histiocytosis (lch) by willman et al . In 1994 (1). Langerhans cells are a type of nonlymphoid mononuclear cells involved in inflammatory responses and also in neoplastic processes . They are immature dendritic cells which express lysosomal enzymes cd1... |
Glucocorticoids (gcs) are among the most effective drugs used in the treatment of hematopoietic malignancies of the lymphoid lineage in virtue of their ability to induce apoptosis of these cancerous cells [13]. The main hematopoietic cancer types that respond well to gc therapy include t acute lymphoblastic leukemia (t... |
Advances in cancer treatment have resulted in improved relative survival rates . However, many oncology patients are faced with treatment - related symptoms and conditions that lead to increased use of health services, including emergency departments (eds). Febrile neutropenia (fn) is such a condition and remains one o... |
Cotton is an economically important plant grown world - wide as a principal source of staple fiber and vegetable oil . A great deal of effort has been made to improve cotton cultivation and characteristics by genetic engineering, such as adapting advantageous varieties to new geographical areas, increasing protein and ... |
We tested a structured relaxation program on nine patients with a diagnosis of schizophrenia suffering from akathisia . All patients were rated on barnes akathisia scale (bas) before the relaxation program, immediately after and again one week later . The mean bas score was before the relaxation 3.3 which reduced to 1.... |
Viruses are divided into two similar - sized groups depending on whether the virus particle contains dna or rna, and, as causes of human fatality, rna viruses are by far the more important (1). New viral diseases continue to appear as a result of several changes in human activity: travel, population growth, interaction... |
Cryptogenic organizing pneumonia (cop), also known as bronchiolitis obliterans organizing pneumonia (boop), is a relatively rare disorder with distinctive clinical, imaging and pathological features . The pathological findings are characterized by plugs of granulation tissue lying within small airways, alveolar ducts a... |
Since 2006, surveillance physicians have listed and collected blood from those patients encephalitis, defined as fever or history of fever with axillary temperature> 38.5c (101.3f) and altered mental status, new onset of seizures, or new neurologic deficit in patients admitted to 3 nipah surveillance hospitals: rajshah... |
Since chitosan is insoluble in water, the use of chitosan in basic environment is limited and hence delivery of drugs to the intestine is not possible . A derivative of chitosan, that is cmc, is soluble in water [1, 2]. Amphoteric polyelectrolyte hydrogels possessing both positive and negative charges, and many researc... |
Dental caries in primary teeth has been widely studied in many countries worldwide since it is known to be one of the most common oral diseases of childhood . However, figures to quantify the prevalence of such disease in palestine are almost inexistent . It is extremely important to study the prevalence of dental cari... |
Stroke, after myocardial infarction (mi), is the second leading reason for mortality in iran as with many countries worldwide . The epidemiology of stroke has already been investigated in the american, european, african, and asian countries . No comprehensive study has yet investigated the epidemiology of stroke, parti... |
Angiogenesis, the formation of new blood vessels, is essential for tumor growth and metastasis and inhibition of angiogenesis is an important new approach for therapy of many cancers [1, 2]. A principal regulator of angiogenesis is vascular endothelial growth factor (vegf). The vegf family is comprised of at least five... |
Muscle dysfunction of the leg is very common in children with spastic diplegia cerebral palsy (cp)1 . Spasticity causes muscle stiffness and weakness, and decreases daily functional activities including standing and walking2 . Passive muscle stretching is a common physical therapy for decreasing the spasticity of child... |
Chirality is a hallmark of biological systems: proteins are composed of l - amino acids and dna and rna are composed of -d - nucleotides . It has, therefore, been widely accepted that enzymes that must correctly bind ligands and catalyze chemistry on their respective substrates, will invariably show high chiral selecti... |
Parasitic infections are increasing worldwide due to rapid urbanization of cities, global warming, and international traveling . The diagnosis of parasitic diseases of the respiratory system is challenging because clinical manifestation and radiological findings are not specific . The larvae can cause airway inflammati... |
Muscle strength and power have been considered strong exogenous stimuli that are able to improve sports performance and promote therapeutic effects in several pathological conditions characterized by muscle wasting, such as cancer, disuse, sepsis, and sarcopenia [1, 2]. In this context, resistance exercise (re) has dem... |
This study was approved by king fahad medical city (kfmc) institutional review board (irb) in riyadh, kingdom of saudi arabia . All patients had a baseline brain mri, video - eeg recording, and a pre - surgical neuropsychological assessment composed of addenbrooke s cognitive examination - revised (ace - r),5 handednes... |
Ventriculoperitoneal shunt (vps) is a well - established cerebrospinal fluid (csf) diversion procedure in cases of hydrocephalus . There are a lot of complications associated with this procedure and shunt extrusion via different natural orifices is one of them . Transanal and per abdomen shunt extrusion are well docume... |
Recently, new oral anticoagulants have been approved as alternatives to warfarin for patients with atrial fibrillation . Rivaroxaban is one of the novel anticoagulants, which is an oxazolidinone derivative and inhibits both free factor xa and factor xa bound with the prothrombinase complex . It is a highly selective di... |
All pcos patients met all three criteria of the revised 2003 rotterdam european society of human reproduction and embryology (eshre)/american society of reproductive medicine (asrm) pcos consensus workshop group diagnostic criteria . The three criteria are 1) oligo- and/or anovulation, 2) clinical and/or biochemical si... |
The term neuroendocrine reflects the origin of endocrine cells from the embryonic neural crest . Neuroendocrine cells are characterized by their ability to produce and secrete different peptides and neuroamines . They aggregate in classical endocrine glands (e.g. Hypothalamus and the pituitary gland) or in the diffuse ... |
Toxoplasma gondii is an obligate intracellular parasite that infects a variety of mammals and birds, causing toxoplasmosis . T. gondii is an important foodborne parasite that is primarily transmitted from animals to humans through the consumption of infected meat . In some countries, pork is the most common meat consum... |
Spontaneous splenic rupture occurs usually secondary to abdominal trauma, most often in a spleen affected by infection or haematological malignancy . Spontaneous splenic rupture is extremely rare, especially presenting in a patient subsequently diagnosed with splenic marginal cell lymphoma (smzl), which itself is rare ... |
Self - esteem is an important state of mind which allows individuals to accept themselves as they are and be self - confident . Rosenberg (1965) considered self - esteem as the positive or negative attitude of an individual toward himself . If an individual has a positive attitude in self - assessment, his self - estee... |
Neuromyelitis optica (nmo) or devic's disease is a rare inflammatory, demyelinating disease of the central nervous system (cns) that predominantly targets the optic nerves and spinal cord 1 . The disease was first described in 1870 by albutt and 24 years later, devic described the clinical characteristics of nmo the di... |
A 16-month old, baby girl, weighing 9.5 kg and measuring 74 cm, visited the hospital because of a cough . In a chest radiograph done under the suspicion of an upper respiratory infection, a round foreign object with a diameter of 21 mm was detected in the upper esophagus (fig . 1). In a sleep endoscopy, it was confirme... |
Lung cancer is the main cause of cancer deaths both in poland and in the world . Non - small cell lung cancer accounts for about 85% of all lung cancers, and the progress in its treatment is still not very satisfactory . The therapeutic procedure of choice is surgery, but only every fifth patient qualifies for it . Thi... |
Diffuse gliomas are the most common primary brain tumors in adults and encompass a heterogeneous group of tumors with different histopathological features, aggressiveness, imaging, response to treatment and survival . They are primarily defined by the histopathological tumor tissue analysis and subdivided by the world ... |
Computational probe mapping is frequently applied in structure - based drug design (sbdd) to identify potential binding pockets along a protein surface (i.e., hot spots). However, mapping is usually limited by the implementation of gas - phase minimizations, wherein protein flexibility and solvent competition are ignor... |
Autoimmune hepatitis (aih) is characterized by chronic necroinflammation, manifesting as severe lobular necrosis and inflammation with broad areas of parenchymal collapse with no known cause . In fact, aih might be associated with a number of other autoimmune diseases,1 but the exact mechanisms of onset remain unknown ... |
European rabbits (oryctolagus cuniculus; figure 1) have played an important role as animal models in immunology for many decades . Today, rabbits are still a major source for a wide variety of monoclonal antibodies (mabs) and polyclonal antibodies (pabs) with broad utility . Pabs can be described as a set of different ... |
All animal procedures were performed in accordance with the arvo statement for the use of animals in ophthalmic and vision research and were approved by the baylor scott & white institutional animal care and use committee . Domestic male pigs (812 weeks old, 811 kg) were purchased from real farms (san antonio, tx, usa)... |
The processes that lead to the gradual atrophy of brain cells, and thus to dementia, are affected by many different factors . Some researchers have called attention to the impact of activity over the lifespan, particularly in later periods of life, on the development of dementia . Although the results of research on th... |
Currently, virtually any psychiatric diagnosis is made through a combination of patient interviews, checklists, or self - report questionnaires, which rely on the symptoms coded in the diagnostic and statistical manual of mental disorders, either the fourth edition1 or the recently introduced fifth edition.2 yet, consi... |
There was a time when numerous asthmatics had to be treated with systemic corticoids either on a regular basis or with repeated short courses in order to achieve asthma control . While inhaled 2 agonists became available in the seventies it took until late eighties to have corticoids administered by the inhaled route (... |
The search strategies used for this review involved literature searches of the medline and psychinfo electronic databases . The main heading terms included major depressive disorder, neurobiology, antidepressant, hippocampus, brain - derived neurotrophic growth factor, glucocorticoids and monoamines . As part of the re... |
Surface interactions of liquids in porous media are of great importance, particularly in the field of heterogeneous catalysis,[15] and the ability to understand surface interactions is essential for efficient and rational catalyst design . However, probing liquid surface interactions in liquid - saturated porous media ... |
Juvenile polyposis syndrome, a rare disorder in children, is characterized with multiple hamartomatous polyps in alimentary tract . A variety of manifestations include bleeding, intussusception, or polyp prolapse . In this study, we present an 8-month - old male infant of juvenile polyposis syndrome initially presentin... |
The phylum apicomplexa includes a large group of protozoan parasites responsible for a wide range of animal and human diseases . Among the human pathogens are plasmodium falciparum and plasmodium vivax, the major causative agents of human malaria, as well as cryptosporidium parvum and toxoplasma gondii, which are parti... |
We have observed a case of renal involvement complicated by granular corneal dystrophy type ii (gcd2). Gcd2, also known as avellino corneal dystrophy (cd), is an autosomal dominant disorder caused by a mutation in the transforming growth factor--induced (tgfbi) gene . This mutation can be found in several distinct auto... |
A 60-year - old male patient, with a known history of arterial hypertension and type-2 diabetes mellitus, was referred to the outpatient echocardiography laboratory to undergo stress echocardiography because of recent episodes of chest pain occurring on mild exertion . He was on drug therapy with angiotensin - receptor... |
Natriuretic peptides are a family of hormones, sharing similar chemical structure (a characteristic 17-amino acid ring structure, stabilized by a cysteine bridge, which contains several invariant amino acids and variable c- and n - terminal tails) and biological function, with relevant effects in cardiovascular physiol... |
Forty - five - year - old male shelter resident, chronic alcoholic, chronic smoker, and marijuana abuser presented to emergency department (ed) with complaints of intermittent fever with night sweats and productive - cough for 10 days with yellowish sputum associated with pleuritic chest pain . He complained of general... |
Porcine reproductive and respiratory syndrome virus (prrsv) was first reported in north america in 1987, and is one of the most economically important diseases in the swine industry . Infection with prrsv is characterized by two clinical signs: reproductive failure in sows during the early - to - late stage of gestatio... |
Tooth wear (tw), also known as tooth surface loss (tsl), is an insidious and cumulative multifactorial process involving destruction of enamel and dentine which can threaten tooth survival and the oral health related quality of life of affected individuals [1, 2]. Despite the overall trends towards improved oral health... |
There is extensive evidence that benzodiazepines, the most widely prescribed psychotropic drug class (greenblatt et al 1983), induce anterograde amnesia in both humans and animals (lister 1985; thiebot 1985). The findings of several experiments suggest that the anxiolytic properties of benzodiazepines involve effects m... |
Syphilis is a chronic systemic infectious disease caused by treponema pallidum, a microaerophilic spirochete, whose transmission occurs mainly by sexual contact . Its course is characterized by a multistage evolution, in a total of 4 distinct clinical stages in cases of non - treated disease, in which symptomatic phase... |
Inflammatory bowel disease (ibd) is a common diagnostic and therapeutic problem, affecting patients at increasingly young ages . A standard diagnostic method includes macroscopic assessment of the intestinal mucosa during colonoscopy and histopathological evaluation of the obtained biopsies . According to porto criteri... |
Periodontal diseases (pd) are chronic inflammatory disorders encompassing destructive and nondestructive diseases of the periodontal supporting tissues of the teeth . Aggressive periodontitis is characterized by severe and rapid loss of periodontal attachment often commencing at or after puberty . Even though the diagn... |
Parasitic protozoans of the phylum apicomplexa are the most prevalent and successful pathogens known to humankind . Today, half of the world's population is at risk of malaria caused by four plasmodium species, and more than 50 billion livestock reared for food production suffer from debilitating intestinal diseases ca... |
Giant cell tumour is the commonest benign bone tumour arising at the epiphyseometaphyseal regions of long bones . Around the knee there are very few similar cases reported worldwide and it is the purpose of this report to describe the management of such a case . A 17 year old girl presented with swelling of ankle and p... |
Diagnostic hysteroscopy for direct assessment of the uterine cavity has been a relatively recent acquisition in the armamentarium of the gynecologists . In an outpatient setting, the entire evaluatory workup takes at least two to three visits prior to arriving at a definitive diagnosis and commencement of appropriate t... |
Endodontically treated teeth presenting partial or total destruction of crowns require reconstruction to create a core to provide mechanical conditions for the indirect restoration to be fixed and remain in function for a long period . The materials most employed for that purpose are composite resins and cast metallic ... |
Lung transplantation is an established therapeutic option for patients with advanced cystic fibrosis (cf). The success of the first transplant for a patient with cf in 1983 spurred further refinement of the management and selection criteria of patients, leading to significant survival benefit . However, patients with a... |
Acute promyelocytic leukemia (apl) is one of the most characteristic subtypes of aml in which abnormal promyelocytes predominate within peripheral blood or bone marrow . Also, t(15;17)(q22;q21) shows a characteristic chromosomal translocation in apl, observable in 70 - 90% of apl patients . Owing to all trans - retinoi... |
The three most commonly encountered forms of mercury are metal vapor (hg), ionic compounds (hg) and organic mercury, principally methyl mercury (hgch3). Organic mercury is the most deadly of the mercury compounds, probably due to its ability to penetrate cells . Within the cell it can destroy various components selecti... |
Type 2 diabetes mellitus (t2 dm) has become a worldwide epidemic . It is estimated that 60% of the world's diabetic population is in asia . This rapid increase in the prevalence of t2 dm in asia has been fuelled by urbanization, economic growth and associated changes in diet and physical activity levels . Specifically,... |
A recent survey showed that oral cancer, which accounts for 2.8% of all malignant tumors in europe, is the most common cause of maxillofacial defects . Moreover, the incidence of oral cancer in china is relatively high compared with the rest of the world . Severe deficiencies in appearance, pronunciation and swallowing... |
Administrative qof data describing performance of family practices under the program were analyzed for the years 20042008 (3). Data for each family practice included the number of registered diabetic subjects, the proportion of eligible subjects who achieved the targets, and the proportion of diabetic subjects excluded... |
Polycystic ovary syndrome (pcos) is a heterogeneous syndrome, involving a growing number of women in reproductive age, diagnosed on the basis of three different factors: oligo- or anovulation, clinical / biochemical hyperandrogenism, and polycystic ovary, with the presence on ultrasound of 12 follicles in each ovary me... |
Chronic mastitis (cm) is a group of diseases characterized by chronic inflammation of the breast, affecting mainly women of reproductive age in their fourth decade [13]. Cm is histopathologically defined as inflammation of the breast, with the microabscess formation and/or the presence of granulomas . This disease gene... |
Despite the explosive increase in cancer genomics data, the actual application of genomics data and approach to clinics offers big challenges [1, 2]. The main reason for the delay in the application to clinics is non - connectivity between bioinformaticians, non - clinical scientists, and clinicians . Clinicians are no... |
Atherosclerosis represents a major factor of coronary heart disease characterized by the formation of fat - laden plaque in large and medium - sized vessels . During atherogenesis, the endothelial layer of the vessels is constantly confronted with a range of stress signals . Elevated levels of circulating oxidized low ... |
Removal of third molars is a common procedure in oral surgery and it is associated with postoperative complications such as pain, swelling and trismus . Therefore, several medications such as corticosteroids and non - steroidal anti - inflammatory drugs are often recommended despite their common side effects such as bl... |
The transversus abdominis plane (tap) block provides effective post - operative analgesia after abdominal surgery . Rafi first described tap block, who injected local anesthetic through the ilio - lumbar triangle of petit within the tap between the internal oblique muscle and transversus abdominis muscle utilizing the ... |
A retrospective review of clinical records of late postpartum eclampsia patients who had presented with acute onset of visual and/or neurological symptoms to the emergency department of a medical college hospital in south india between april 2009 and may 2013 was done . All patients had underwent mri with diffusion wei... |
Isotretinoin is a systemic synthetic retinoid used to treat moderate to severe nodulocystic acne vulgaris that is not responding to other therapies, as well as a number of other dermatologic diseases, including psoriasis, hidradenitis suppurativa, ichthyosis, lesions associated with lupus erythematosus, some cases of s... |
Gentamicin (gm) is one of the amino glycoside drugs used in gram - negative infections . Nephrotoxicity is specified by renal dysfunction, which is distinguished by increasing serum levels of blood urea nitrogen (bun) and creatinine (cr). Compounds such as lycopene, metformin, garlic, vitamin e, probucol, and erythropo... |
Institutional review board approval was obtained from the wake forest university, and informed consent forms were completed for all participants . Items for four concepts identified in the literature were glucose control, well - being and side - effects, lifestyle burden, and treatment complexity and convenience and we... |
The incidence of infective endocarditis (ie) remained relatively stable from 1950 through 2000 at about 3.6 to 7.0 cases per 100,000 patient - years.1 in selected areas, the incidence may rise because of the concentration of populations at uniquely high risk of infection, specifically intravenous (iv) drug abusers . Th... |
Six hundred officers were recruited from the police departments of new york, ny, and oakland and san jose, calif, usa . Fifty - two percent of the sample was caucasian . The mean age was 36,50 years (standard deviation [sd])=6.96). Years in the police force everaged 12.37 (sd=6.78). Number of exposure to critical incid... |
The most important goal of health systems is improving quality, effectiveness and efficiency of healthcare services (1). However, scattered health information has a negative effect on healthcare services and would impose more expenses to the healthcare system (2). Electronic health record (ehr) as a modern method of st... |
Oral lichen planus (olp), a common mucocutaneous disease, was first described by wilson in 1869 . Poor described the formation of cavities in lichen planus of the mucosa, corresponding in character to subepithelial bullae and gougerot described the reticular, annular, plaque, ulcerated, dotted and sclerotic forms of li... |
Age - related structural and functional deterioration of sensory and motor mechanisms, especially of the vestibular system, is a leading cause of dizziness and imbalance in older adults (1, 2). It is well established that older individuals with a history of imbalance and dizziness are at higher risk of fall related inj... |
This retrospective, cohort study includes patient data collected at 5 etus operated by international medical corps (imc) in liberia and sierra leone from 15 september 2014 to 15 september 2015 as part of its comprehensive response to the west african evd epidemic . All patients who presented to the study etus with symp... |
Gastrointestinal perforations constitute one of the commonest surgical emergency encountered by surgeons [1, 2]. Management of these patients continues to be highly demanding despite the advances made in diagnosis and surgical therapy . The etiological spectrum of perforation peritonitis in india differs significantly ... |
The term isotopic response connotes the occurrence of a new skin disorder at the site of another, unrelated, and already healed skin disease . Since the introduction of this phenomenon in dermatology, a variety of dermatoses we hereby describe a young girl who developed lesions of lichen planus pemphigoides (lpp) over ... |
Charcoal was originally used for localizing a non - palpable tumor mass (1), however, it is being increasingly used for localizing suspicious metastatic cervical lymph nodes or recurrent tumors in the thyroid bed after surgery (2).although, charcoal is known to be safe and stable when injected subcutaneously for preope... |
Lesch - nyhan syndrome was first recognized and clinically characterized in 1964 by lesch and nyhan, observing two affected brothers . Lns is a rare x - linked recessive disorder, resulting from a mutation on the gene encoding for the enzyme hypoxanthine - guanine phosphoribosyltransferase (hgprt), located on the long ... |
This review will focus on scorpion venom and its major toxins and their functions in excitable cells . It well also compares some of the research done on scorpions from different parts of the world to highlight open areas of interest . These animals are found in all continents except antarctica, and are known to cause ... |
Cytokines are known to play essential roles in hematopoiesis such as the regulation of differentiation and production of progenitor cells and mature blood cells . The knowledge of cytokine function has not only contributed to the development of supportive therapies (i.e., erythropoietin (epo)), but dysregulation of cyt... |
The study was conducted at the microbial containment complex, national institute of virology (niv), pashan, pune, india . Infected mosquitoes were kept in plastic jars inside mosquito cages and all these experiments were carried out inside a bio - safety level-2 laboratory . Normal as well as infected mosquitoes were m... |
Signature peptide based quantification of proteins using liquid chromatography - tandem mass spectrometry (lc - ms / ms) is increasingly used to measure endogenous or therapeutic proteins because it is a high - throughput, selective, and sensitive method when compared with other quantitative proteomics and immunoblotti... |
Advances in treatment have led to an increase in survival in people with cystic fibrosis (cf). As patients age with cf, they experience an increased rate of complications, including cystic fibrosis related diabetes (cfrd). Cfrd results from the progressive inflammatory destruction of the pancreas [2, 3] and leads to th... |
. The baff / april axis plays an important role in the pathogenesis of various autoimmune diseases including sle; inhibitors of this axis are therefore useful in treatment of these disordersresults from bliss-52 and bliss-76 trials have shown belimumab to be efficacious in treating patients with sleserious adverse effe... |
Ovarian cancer affects close to 25,000 women yearly and most patients have extensive metastatic disease at the time of diagnosis.ovarian cancer metastasis is thought to result from exfoliation of tumor cells from the ovary and/or direct extension onto the peritoneal surfaces, the omentum, and the surface of organs such... |
Imaging techniques play an important role in the diagnosis, staging, and follow - up of cancer patients . While standard imaging techniques, such as computed tomography (ct), are based on differences in the anatomical structure of the tissues, positron emission tomography (pet) uses radiolabeled molecular probes to ass... |
Review articles in the scientific literature can be classified as a general review article, a systematic review (sr), or meta - analysis (ma). The purpose of a review article is to provide readers with a summary of published research in a particular field . Reviews usually focus on areas of progress over the recent pas... |
Cementoblastoma in the current world health organization classification of odontogenic tumor, is in the category of tumors of mesenchyme and/or odontogenic ectomesenchyme with or without odontogenic epithelium . It generally occurs in young persons, comprises <1 - 6.2% of all odontogenic tumor and is characterized as b... |
Understanding the physical interactions governing the structure and dynamics of ribonucleosides should improve the accuracy of simulations of ribonucleic acid (rna) molecules . Methods for simulating biological systems include residue - centered force fields (coarse - grained),(1) atom - centered force fields (amber,(2... |
Fructose is a monosaccharide that is widely available in natural food sources such as fruits and honey . However, in most countries the main source of fructose is from sucrose, a disaccharide composed of equal portions of fructose and glucose . In the united states another major source of fructose is high - fructose co... |
On february 23, 2010, a military service member preparing for deployment received smallpox vaccination and was counseled by the us department of defense about postvaccination care and infection control . On february 27, the index patient wrestled 2 persons in a semiprofessional match, during which the dressing covering... |
Strontium titanate (srtio3, sto), the prototypical perovskite oxide, has long been known to show interesting effects taking place on its surfaces . For example, it is commonly used as a substrate for the growth of complex oxides, and it supports the formation of a two - dimensional electron gas on its surfaces . Furthe... |
According to the world health organization's classification of glomerular diseases, both thrombotic microangiopathy (tma) and fibrillary glomerulonephritis (fgn) consist of glomerular lesions, the former in the context of a vascular disease and the latter in the setting of a metabolic disease . Anti - glomerular baseme... |
Traditionally, the presence of specific clinical signs and symptoms coupled with abnormalities in cardiacspecific measurements and estimates of endorgan dysfunction generates an integrated view of an individual patient's risk profile . Recently, the broad acceptance of novel bloodbased biomarkers has emerged in the are... |
Emergency peripartum hysterectomy (eph) is a major surgical venture invariably performed in the setting of life threatening hemorrhage during or immediately after abdominal and vaginal deliveries [15]. Despite advances in medical and surgical fields, post partum hemorrhage continues to be the leading cause of maternal ... |
After obtaining institutional ethical committee approval and written informed consent, 50 asa physical status i - iii patiets, aged from 30 to 75 years, undergoing elective major abdominal surgery were included in this prospective, randomized, double blind study . Patients with cardiac desease, uncontrolled hypertensio... |
Debate regarding the indications, timing and technique for tracheostomy seems to have been raging ever since the procedure itself was first described in ancient egypt . The topic is of global interest, with research from a number of continents published during the past few months . These recently published papers add n... |
At indiana universitypurdue university indianapolis (iupui), we have developed a concept called distributed drug discovery (d). Herein is reported the first example of a key component of d: the distributed rehearsal of reagents and their subsequent use in real and virtual catalog production . The premise of d is that t... |
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