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converted_38 | Does physical activity influence gut hormones? | Increases in blood PYY(3-36) levels were dependent on the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in GLP-1 levels were similar between two different exercise sessions., A decrease in serum leptin levels (-48.4%, p < 0.001) was observed after intervention without changes in total ... | yes |
converted_1010 | Is it possible to purify pseudopodia to be used for proteomic analysis? | we developed an approach to biochemically isolate the pseudopodium from the cell body using 3.0-micrometer porous filters for large-scale quantitative proteomic and phosphoproteomic analysis., Recent work using unique subcellular fractionation methodologies combined with spatial genomic, proteomic, and phosphoproteomic... | yes |
converted_995 | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and lineage specification, gfi1aa and gfi1b have distinct roles in regulating primitive and d... | yes |
converted_1411 | Is the ACE inhibitor indicated for lung cancer treatment? | The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease the risk of some cancers, although available data are conflicting. , Using cell viability and fluorescent activated cell sorting analysis tests, we demonstrated that captopril inhi... | no |
converted_285 | Is ospemifene effective for treatment of dyspareunia? | Ospemifene, a novel selective estrogen receptor modulator, has been developed for the treatment of vulvovaginal atrophy and dyspareunia in postmenopausal women. , For the comparison of short-term ospemifene with placebo, parabasal cells (the standardized mean difference [SMD] = -37.5, 95% confidence interval [CI] = -41... | yes |
converted_367 | Is bapineuzumab effective for treatment of patients with Alzheimer's disease? | Thus far, results from two large phase 3 trial programs with bapineuzumab and solaneuzumab, respectively, have brought rather disappointing results., More recently, in phase III studies, bapineuzumab has been discontinued because it did not prove clinically effective (despite its significant effect on biomarkers), whi... | no |
converted_3523 | Is SATB1 positioned close to AT-rich sequences? | Tryptic cleavage and peptide sequence analysis demonstrated that the 98-kD protein is identical to a recently cloned protein, special A-T-rich binding protein 1 (SATB1), Special AT-rich sequence-binding protein 1 (SATB1), a DNA-binding protein expressed predominantly in thymocytes, recognizes an ATC sequence context t... | yes |
converted_1651 | Does SCRIB deregulation promote cancer? | human homologs of Drosophila dlg, scrib, and lgl are cancer-associated genes., Aberrant overexpression of the cell polarity module scribble in human cancer., we show that Scrib is nearly universally overexpressed in cultured tumor cell lines and genetically disparate cancer patient series compared with matched normal t... | yes |
converted_2844 | Does epidural anesthesia for pain management during labor affect the Apgar score of the the infant? | We retrospectively analyzed 93 consecutive single-pregnancy patients who underwent cesarean section with combined spinal-epidural anesthesia. The patients were divided into two groups, depending on the use of 6% HES 130/0.4: group A (461 ± 167 ml of saline-based HES was administered; 43 patients) and group B (HES not ... | no |
converted_691 | Do lincRNAs play a role in human cancer? | Long non-coding RNA H19 increases bladder cancer metastasis, These data suggest that upregulated H19 enhances bladder cancer metastasis by associating with EZH2 and inhibiting E-cad expression, lncRNA H19 is essential for human tumor growth, Previous reports have demonstrated that HOTAIR associates with chromatin modif... | yes |
converted_2561 | Has intepirdine been evaluated in clinical trials? (November 2017) | Using small molecules blocking 5-HT6serotonin receptor (intepirdine), inhibiting BACE activity (E2609, AZD3293, and verubecestat), or reducing tau aggregation (TRx0237) are also currently in Phase III clinical trials. | yes |
converted_4184 | Are interferons defensive proteins? | In response to viral infections, various pattern recognition receptors (PRRs) are activated for the production of type I interferon (IFN I). , activating interferon (IFN) production and positively regulating antiviral response in mammals. , The innate immune system, in particular the type I interferon (IFN) response, ... | yes |
converted_688 | Is Ctf4 involved in sister chromatid cohesion establishment? | In addition to Eco1, several other factors contribute to cohesion establishment, including Ctf4, Ctf18, Tof1, Csm3, Chl1 and Mrc1, but little is known about their roles. Here, we show that each of these factors facilitates cohesin acetylation. Moreover, the absence of Ctf4 and Chl1, but not of the other factors, causes... | yes |
converted_2067 | Can glyburide reduce cerebral edema? | Preclinical studies have shown that a continuous infusion of glyburide blocks edema formation and improves outcome. We hypothesize that treatment with RP-1127 (Glyburide for Injection) reduces formation of brain edema in patients after large anterior circulation infarction., CONCLUSIONS: GAMES-RP was designed to provid... | yes |
converted_2938 | Does Groucho related gene 5 (GRG5) have a role only in late development? | Groucho related gene 5 (GRG5) is a multifunctional protein that has been implicated in late embryonic and postnatal mouse development. Here, we describe a previously unknown role of GRG5 in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of function approaches we ... | no |
converted_1369 | Are microRNA (miR) regulated through DNA methylation of their promoters? | We found that Tcf3 down-regulation in the context of constitutively active Wnt signaling does not result from promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (H3K4me3 and H3-acetylation) and t... | yes |
converted_1713 | Does the Oncotype DX test work with paraffin embedded tissues? | The Oncotype-DX Breast Cancer Assay (Genomic Health, Redwood City, CA) quantifies gene expression for 21 genes in breast cancer tissue by performing reverse transcription polymerase chain reaction (RT-PCR) on formalin-fixed paraffin-embedded (FFPE) tumour blocks that are obtained during initial surgery (lumpectomy, mas... | yes |
converted_1653 | Is imatinib an antidepressant drug? | Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the elective treatment. We retrospectively compared two group of patients, who underwent surgery for GIST before and after Imatinib advent in order to analyze the recurrence and survival rate., Adju... | no |
converted_1223 | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. , Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associati... | yes |
converted_74 | Do patients with Pendred syndrome present congenital deafness? | Pendred Syndrome can be characterized by the triad composed of familial goitre, abnormal perchlorate discharge and congenital deafness., Pendred syndrome is an autosomal recessive disorder characterized by congenital deafness and goiter. , Pendred syndrome comprises congenital sensorineural hearing loss, thyroid goiter... | yes |
converted_4416 | Is periampullary carcinoma (PAC) a relatively rare genitourinary malignancy | Pancreaticobiliary subtype of Periampullary carcinoma (PAC) has a poor prognosis in comparison to the intestinal subtype., MUC1, CK20, and CDX2 immunohistochemical markers can sub-classify periampullary carcinomas into pancreaticobiliary, intestinal, and mixed subtypes., Pancreaticoduodenectomy (PD) is a complex surgic... | no |
converted_3682 | Is indinavir effective for treatment of amyotrophic lateral sclerosis? | Group differences in the rate of decline were not significant between the groups for the ALS Functional Rating Scale (p = 0.36) or for the secondary variables. The toxicity and negative efficacy trends discourage further indinavir trials in ALS. | no |
converted_1037 | Is Vitamin D deficiency in pregnant women associated with gestational diabetes? | Insufficient serum levels of 25-OHD were associated with gestational diabetes (pooled odds ratio 1.49, 95% confidence interval 1.18 to 1.89, Vitamin D insufficiency is associated with an increased risk of gestational diabetes, p, Therefore, it is important to identify potentially modifiable risk factors for GDM. Accumu... | yes |
converted_2072 | Is vemurafenib used for thyroid cancer? | Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial., Vemurafenib, an oncogenic BRAF kinase inhibitor approved for BRAF-positive melanoma, showed clinical benefit in three patient... | yes |
converted_1139 | Are ACTA1 (alpha actin) and NEB (nebulin) genes related to nemaline myopathy? | Nemaline myopathy (NM) is a group of congenital myopathies, characterized by the presence of distinct rod-like inclusions "nemaline bodies" in the sarcoplasm of skeletal muscle fibers. To date, ACTA1, NEB, TPM3, TPM2, TNNT1, and CFL2 have been found to cause NM., Nemaline myopathy (NM) is the most common congenital myo... | yes |
converted_2159 | Is autophagy the process where bacteria ingest viral particles? | Autophagy, a cellular degradation process, Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional proteins and organelles, is a cellular process associated with homeostasis., Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both ... | yes |
converted_271 | Is the Dictyostelium discoideum proteome known? | The Negative Proteome Database (NPD) is populated with pair-wise protein sequence comparisons between each of the following proteomes: Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Dictyostelium discoideum, Chlamydomonus reinhardti, Escherichia coli K12, Arabidop... | yes |
converted_2215 | Does the histone chaperone ASF1 interact with histones H1/H2? | The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4., The central histone H3/H4 chaperone Asf1 comprises a highly conserved globular core and a divergent C-terminal tail. , The histone H3-H4 chaperone Asf1 is involved in chromatin assembly (or... | no |
converted_2073 | Are mutations in the C9orf72 gene associated with macular degeneration? | Over the years, however, growing evidence from clinical, pathological and genetic findings has suggested that ALS and FTD belong to the same clinic-pathological spectrum disorder. This concept has been further supported by the identification of the most common genetic cause for both diseases, an aberrantly expanded hex... | no |
converted_3260 | Can leuprorelin acetate be used as androgen deprivation therapy? | We investigated the health-related quality of life (HRQoL) of long-term prostate cancer patients who received leuprorelin acetate in microcapsules (LAM) for androgen-deprivation therapy (ADT)., Long-term ADT with LAM is a well-accepted, tolerated, effective, and low-burden treatment option for patients with advanced, h... | yes |
converted_62 | Is pregnancy an additional risk during during H1N1 infection? | H1N1 influenza in pregnancy can be associated with severe complications, This case series confirms a high number of complications in pregnant women due to pandemic H1N1/09., Pregnant women might be at increased risk for complications from pandemic H1N1 virus infection., Pregnant women are at increased risk for complica... | yes |
converted_1421 | is there an increase in ultrasound comets after intense exercise? | Healthy athletes developed subclinical increase in pulmonary water content immediately after an Ironman race at sea level, as shown by the increased number of ULCs related to cardiac changes occurring during exercise., Increased EVLW is associated with estimated PCWP and indices of left ventricular systolic and diastol... | yes |
converted_2261 | Has ruxolitinib received FDA approval? | Testing for JAK2 mutations is now included in the World Health Organization (WHO) criteria for the diagnosis of MPN, and in 2011 the oral JAK2 kinase inhibitor ruxolitinib became the first Food and Drug Administration (FDA)-approved drug for the treatment of myelofibrosis. | yes |
converted_2487 | Is there any role of Dlx1 and Dlx2 transcription factors in cortical interneurons? | The postnatal functions of the Dlx1&2 transcription factors in cortical interneurons (CINs) are unknown. Here, using conditional Dlx1, Dlx2, and Dlx1&2 knockouts (CKOs), we defined their roles in specific CINs. The CKOs had dendritic, synaptic, and survival defects, affecting even PV+ CINs. We provide evidence that DLX... | yes |
converted_1874 | Is there an association between Muenke Syndrome and FGFR3 gene mutation? | RESULTS: Forty-four with a positive FGFR3 mutation, median age 9 years, range 7 months to 52 years were enrolled. In addition, 10 unaffected siblings served as controls (5 males, 5 females; median age, 13 years; range, 3-18 years)., Muenke is a fibroblast growth factor receptor 3 (FGFR-3)-associated syndrome, which was... | yes |
converted_1652 | Is cardiac magnetic resonance imaging indicated in the pre-participation screening of athletes? | As modern imaging further enhances our understanding of the spectrum of athlete's heart, its role may expand from the assessment of athletes with suspected disease to being part of comprehensive pre-participation screening in apparently healthy athletes., Finally we will address the role of CMR in pre-participation scr... | no |
converted_3205 | Does RUNX2 inhibit astrocyte differentiation? | The method was able to recapitulate experimentally validated cell-fate determinants, and validation of two predicted cell-fate determinants confirmed that overexpression of ESR1 and RUNX2 in mouse neural stem cells induces neuronal and astrocyte differentiation, respectively. | no |
converted_1255 | Is lenvatinib effective for thyroid cancer? | New insights in the treatment of radioiodine refractory differentiated thyroid carcinomas: to lenvatinib and beyond., However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of what was con... | yes |
converted_694 | Is there a phylogenetic analysis for HIV? | The results of Burst and phylogenetic analysis suggested that the C. neoformans var. grubii strains could be separated into three nonredundant evolutionary groups (Burst group 1 to group 3). , Phylogenetic trees were constructed to evaluate the relationships between the variants, We analyzed pol (protease/reverse trans... | yes |
converted_2429 | Is Apremilast effective for Behcet’s syndrome? | Apremilast is an immunomodulatory agent that works through phosphodiesterase 4 inhibition. A randomized controlled trial has shown that it is effective for the management of oral and genital ulcers and is generally well tolerated., AREAS COVERED: This review provides a digest of all current experience and evidence abou... | yes |
converted_253 | Can life style changes reduce oxidative stress | The CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis. Antioxidant treatment and life style changes are indicated ... | yes |
converted_245 | Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | Gene regulation in Drosophila spermatogenesis: analysis of protein binding at the translational control element TCE., We have previously identified a 12 nucleotide long sequence element, the TCE, that was demonstrated to be necessary for translational control of expression in the male germ line of Drosophila melanogast... | yes |
converted_1669 | Does ghrelin play a role in ischemic stroke? | Recent evidence suggests that ghrelin may also be neuroprotective after injury in animal models of cerebral ischemia., Overall, these experiments point to a neurodegenerative but antiapoptotic effect of endogenous ghrelin in this model of global ischemia, highlighting that further research is essential before we can ap... | yes |
converted_1228 | Is Rheumatoid Arthritis related to myopathy? | Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients, we describe a patient with rheumatoid arthritis and respiratory failure associated with proximal myopathy secondary to HCQ, Occurrence of chloroquine-induced myopathy after low-dose treatment of rheumatoid arthritis for seven years... | yes |
converted_3531 | Is Huntington's disease is caused by expansion of a CTG repeat in the HTT gene on Chromosome 4? | Huntington's disease (HD) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the HD disease protein, huntingtin (HTT)., Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion mutation in the huntingtin (HTT) gene, which results in the HTT protein that con... | no |
converted_1000 | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | PTH can induce skeletal synthesis of another potent phosphaturic hormone, fibroblast growth factor 23 (FGF23), , Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that has recently been identified as a CKD-related factor affecting CRS. , circulating phosphaturic hormone fibroblast growth factor-23 levels,... | yes |
converted_704 | Are CD44 variants (CD44v) associated with poor prognosis of metastasis? | CD44 variants and prognosis, The CD44 variant (CD44v) isoforms have been noted as markers for tumour metastasis and prognosis in several adenocarcinomas., Positive CD44v3 expression was associated with more advanced pathological stage and poorer prognosis than negative CD44v3 expression, CD44v6 expression in the adenoc... | yes |
converted_3234 | Anaplasma phagocytophilum is an obligate gram-negative, intracellular bacterium, yes or no | The genus Anaplasma belonging to the Anaplasmataceae family (order Rickettsiales) comprises obligate intracellular Gram-negative bacteria of veterinary and public health importance. Six species and five types of strains genetically related are currently assigned to the genus Anaplasma including Anaplasma marginale, A. ... | yes |
converted_4408 | Does UBE4B promote renal cancer? | UBE4B might act as an oncogene in regulating RCC development. Therefore it could be served as an effective indicator to predict OS and a potential biomarker for targeted therapy of RCC patients. | yes |
converted_4183 | Is Tranexamic acid effective for intracerebral haemorrhage? | Tranexamic acid did not increase the risk of post-intracerebral haemorrhage seizures in the first 90 days., The primary outcome was not different between the two groups: 26 (52%) patients in the placebo group and 22 (44%) in the tranexamic acid group had intracerebral haemorrhage growth (odds ratio [OR] 0·72 [95% CI 0·... | no |
converted_1030 | Are DNA helicases involved in progeroid syndromes? | Among these syndromes, relevant advances have recently been made in Werner syndrome, one of several progeroid syndromes characterized by defective DNA helicases,, Progeroid syndromes (PSs) constitute a group of disorders characterized by clinical features mimicking physiological aging at an early age., However, all the... | yes |
converted_3812 | Can secondary glioblastoma be caused by brain irradiation? | Prolonged survival in secondary glioblastoma following local injection of targeted alpha therapy with , [Radiation induced glioblastoma: a case report]., We report a surgical case of a 54-year-old woman with a radiation induced glioblastoma., Glioblastoma multiforme following cranial irradiation and chemotherapy for ac... | yes |
converted_528 | Is there any software for automated analysis of immuno-histochemistry images? | The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. , The vein graft s... | yes |
converted_2802 | Does gepotidacin activate bacterial topoisomerase? | GSK2140944 is a novel bacterial topoisomerase inhibitor in development for the treatment of bacterial infections. | no |
converted_1391 | Can RNASeq be used for the analysis of nascent transcripts? | Here, we utilize nascent RNA sequencing to document dosage compensation during transcriptional elongation., Here we show that RNA-seq can also be used for studying nascent RNAs undergoing transcription, Conversely, the nuclear fraction shows an enrichment of unprocessed RNA compared with total RNA-seq, making it suitab... | yes |
converted_2559 | Are there ways of joint Bayesian inference of risk variants? | Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases., Genome wide association studies (GWAS) provide a powerful approach for uncovering disease-associated variants in human, but fine-mapping the causal variants remains a challenge. This is partly r... | yes |
converted_1526 | Is there an association between presenteeism and depression? | Presenteeism was positively associated with severity of depression (Health and Work Performance Questionnaire, P < 0.0001; WPAI, P < 0.0001)., Statistically significant correlations (0.32-0.53) were found between presenteeism and increasing disability, fatigue, depression, anxiety, and reduced quality of life. , Presen... | yes |
converted_1580 | Do Conserved noncoding elements act as enhancers? | The aCNEs are rich in tissue-specific enhancers, Transgenic zebrafish assay of some human CNE enhancers that have been lost in teleosts, Conserved noncoding elements (CNEs) in vertebrate genomes often act as developmental enhancers,, In all four cases where the zebra fish and human CNE display a similar expression patt... | yes |
converted_1974 | Does mTOR regulate the translation of MAPKAPK2? | mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype., Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show p... | yes |
converted_162 | Is there an increased risk for cancer in Dyskeratosis Congenita? | People with DC are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML), solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis, Clinical progression of the disease can lead to aplastic anemi... | yes |
converted_2782 | Can breastfeeding confer protection from type I diabetes? | In the neonate and infant, among other benefits, lactation confers protection from future both type 1 and type 2 diabetes. | yes |
converted_3486 | Are there lncRNAs that control the extent of neuronal outgrowth? | Regulation of Neuroregeneration by Long Noncoding RNAs., Here, we profiled gene expression following sciatic nerve crush in mice and identified long noncoding RNAs (lncRNAs) that act in the regenerating neurons and which are typically not expressed in other contexts. We show that two of these lncRNAs regulate the exten... | yes |
converted_2833 | Is LRP1 interacting with Urokinase receptor? | Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1., Here we investigated whether direct interaction between uPAR, a glycosyl-phosphatidylinositol-anchored p... | yes |
converted_3384 | Does the chromatin remodeling complex, RSC target H2A.Z nucleosomes? | In contrast, the upstream nucleosome which covers the TATA box under repressed conditions is shifted approximately 50 bp further upstream by the ATP-dependent chromatin remodeler RSC upon activation. It is marked with the histone variant H2A.Z and H4K16 acetylation in active state, In RSC-depleted cells, NFRs shrink su... | yes |
converted_741 | Is the circadian clock involved in ribosome biogenesis? | The circadian clock coordinates ribosome biogenesis., Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of transl... | yes |
converted_677 | Are there any urine biomarkers for bladder cancer diagnosis? | CONCLUSIONS: Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer, Novel promising markers are in v... | yes |
converted_1444 | Is arimoclomol a co-inducer of the heat shock response? | Arimoclomol is a hydroxylamine derivative, a group of compounds which have unique properties as co-inducers of heat shock protein expression, but only under conditions of cellular stress. , In this review we summarize the evidence for the neuroprotective effects of enhanced heat shock protein expression by Arimoclomol ... | yes |
converted_1416 | Is c-myc subject to regulation by the circadian clock? | The current study encompasses the investigation of simultaneous expression of four circadian clock genes (Bmal1, Clock, Per1 and Per2) and three clock-controlled cell cycle genes (Myc, Cyclin D1 and Wee1), Our results suggest that aberrant expression of circadian clock genes can lead to aberrant expression of their dow... | yes |
converted_4586 | Is Mediator present at super enhancers? | BRD4 and Mediator were found to co-occupy thousands of enhancers associated with active genes., Master transcription factors and mediator establish super-enhancers at key cell identity genes, Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expr... | yes |
converted_501 | Is Kanzaki disease associated with deficiency in alpha-N-acetylgalactosaminidase? | Kanzaki disease (OMIM#104170) is attributable to a deficiency in alpha-N-acetylgalactosaminidase (alpha-NAGA; E.C.3.2.1.49), which hydrolyzes GalNAcalpha1-O-Ser/Thr. , Our findings suggest that the association of alpha-NAGA with its substrates is strongly affected by the amino acid substitution at R329 and that the as... | yes |
converted_238 | Can valproic acid act as an activator of AMPK? | Here we demonstrate that VPA is a novel activator of AMP-activated protein kinase (AMPK), a key regulator of cellular metabolism, using primary mouse and human hepatocytes., These studies are the first to establish VPA and its metabolites as in vitro activators of AMPK. | yes |
converted_4040 | Is there an upper limit on the functional fraction of the human genome? | Mutational load considerations lead to the conclusion that the functional fraction within the human genome cannot exceed 25%, and is probably considerably lower. | yes |
converted_2843 | Is ADP-ribosylation a PTM? | ADP-ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine dinucleotide (NAD+) to modify target proteins with ADP-ribose, Poly-ADP-ribosylation (PARylation) is a protein posttranslational modification (PTM) that is critically involved in many biological processes that are linked to cell stress... | yes |
converted_1845 | Can the Micro-C XL method achieve mononucleosome resolution? | We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution, We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution., Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome., Micro-C XL provid... | yes |
converted_1765 | Is the toxin produced by Clostridium botulinum always deadly? | Animals treated with trace elements recovered. It appears that intestinal microbiota dysbiosis and trace element deficiency could explain the extensive emergence of chronic Botulism., The patient was treated with human botulism immune globulin and had rapid recovery in weakness. A stool sample from the patient was posi... | no |
converted_3706 | Do genes with monoallelic expression contribute proportionally to genetic diversity in humans? | Genes with monoallelic expression contribute disproportionately to genetic diversity in humans., An unexpectedly large number of human autosomal genes are subject to monoallelic expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic variation across human populations. This increased diver... | no |
converted_390 | Does PU.1 (SPI1) affect NF-kB binding? | Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs)., Within 1217 bp of upstream sequence, 3 sites for N... | yes |
converted_3356 | Is golimumab effective for sarcoidosis? | Introduced monoclonal antibodies (infliximab, etanercept, adaluimumab, golimumab, rituximab), tested for efficacy in other pathologies associated with the formation of granulomas, have a limited application in patients with SA. , Although treatment was well tolerated, neither ustekinumab nor golimumab demonstrated effi... | no |
converted_2166 | Is intraoperative radiotherapy used for treatment of glioblastoma? | 1) Intraoperative radiotherapy ( IOR , 1,000-2,000 rad) was applied in 13 cases; the 2-year survival was 41.6%. , The median survival time after IORT was 12 months for 9 patients with glioblastoma or anaplastic astrocytoma, while it was 51 months for 8 patients with less infiltrative tumors (ependymoma, anaplastic epe... | no |
converted_328 | Can sorafenib activate AMPK? | Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. , Persistent activation of AMPK by sorafenib finally led to the impairment of glucose metabolism both in MCF-7 and SKBR3 cells as well as in the highly glycolytic MDA-MB-231 cell... | yes |
converted_1331 | Is there a difference in the rate between gene fusion and gene fission? | we illustrate arrangement diversity within closely related organisms, estimate arrangement turnover frequency and establish, for the first time, branch-specific rate estimates for fusion, fission, domain addition and terminal loss., Rate and polarity of gene fusion and fission in Oryza sativa and Arabidopsis thaliana, ... | yes |
converted_2735 | Is Cystatin D a biomarker? | Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury. | yes |
converted_4277 | Αre plants from the genus Strychnos the original source of curare? | Poisons are widespread in plants and animals and humankind has often tried to turn them to its own advantage. Owing to their poisonous properties, some species of Strychnos genus have been employed mainly in hunting and fishing, as an adjunct to weapons used not only in the search of food and clothes, but also for prev... | yes |
converted_3936 | Is cabergoline used for treatment of the Nelson's syndrome ? | Due to a rapid regrowth of the tumour, the patient did not receive gamma-knife therapy and was treated with cabergoline and somatostatin analogue for some time. , Identification of D(2) receptors in corticotroph tumors led to clinical trials of cabergoline therapy in limited cases of Nelson's syndrome, ectopic ACTH-sec... | yes |
converted_3090 | Is eculizumab used for treatment of myasthenia gravis? | Eculizumab treatment improved symptoms compared with placebo in a phase II study in patients with refractory gMG. D, Eculizumab (Soliris) has been approved in several countries for refractory forms of generalized seropositive severe myasthenia gravis. , The humanized monoclonal antibody eculizumab (Soliris®) is a compl... | yes |
converted_846 | Can bioprinting use human cells? | In this study, human adipose-derived stem cells (hASCs) were printed in a free-scalable 3D grid pattern by means of LaBP., Additionally, we provide the proof that even pre-differentiated hASCs could be utilized for the generation of 3D tissue grafts. , To explore the three dimensional(3D)bioprinting technology, using ... | yes |
converted_1595 | Does TRIM37 gene mutation causes Mulibrey nanism? | OBJECTIVE: We studied pubertal development and fecundity in males with Mulibrey nanism (MUL) caused by mutations in the TRIM37 gene., In MUL, mutations in TRIM37 lead to disturbance of sexual maturation, and fertility is severely compromised. , It is caused by recessive mutations in the TRIM37 gene encoding for the per... | yes |
converted_4263 | Is FTY720 FDA approved? | FTY720 (Fingolimod) is a known sphingosine-1-phosphate (S1P) receptor agonist that exerts strong anti-inflammatory effects and was approved as the first oral drug for the treatment of multiple sclerosis by the US Food and Drug Administration (FDA) in 2010. | yes |
converted_1102 | Is cocaine use associated with increased risk for intracerebral hemorrhage? | Stroke in crack-cocaine abusers is increasingly recognized., There were significant differences between crack-cocaine cases and controls in age (48.7 years vs. 55 years) (P = 0.0001), male gender (65.6% vs. 40.9%) (odds ratios, OR = 1.64, 95% CI 1.22-2.21), arterial hypertension (61.1% vs. 83.9%) (OR = 0.30, 95% CI 0.1... | yes |
converted_1138 | Does surgery for ovarian endometriomas improve fertility? | CONCLUSION: Endometriomas per se appear to be the main cause of the reduced long-term reproductive performance of the affected patients, with little or no contribution from surgery. Furthermore, endometrioma surgery seems to improve the success rates of fertility treatment., Amongst the 38 women desiring pregnancy afte... | yes |
converted_2790 | Is the PINES framework being used for the prediction of coding variants? | PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants., Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the functional impact of noncoding variants by integrating epigenetic annotations in a phenotype-dependent... | no |
converted_4570 | Is AGO2 related to cytokinesis? | AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division., We suggest that AGO2 is part of a regulatory mechanism triggered by cytokinetic stress to generate the appropriate micro-environment for local transcript homeostasis. | yes |
converted_3773 | Do circular exons increase gene expression? | Each of these species was present at very low copy numbers in primary and cultured cells; however, only the expression of ANRIL isoforms containing exons proximal to the INK4/ARF locus correlated with the ASVD risk alleles., These results identify novel circular RNA products emanating from the ANRIL locus and suggest c... | no |
converted_680 | Is signal transducer and activator of transcription-3 (STAT3) critical for tumor angiogenesis progression? | (STAT3) is critical for cancer progression by regulating tumor cell survival, proliferation, and angiogenesis. Herein, we investigated the regulation of STAT3 activation and the therapeutic effects of Icaritin, a prenyl flavonoid derivative from Epimedium Genus, in renal cell carcinoma (RCC). , Overall, these results... | yes |
converted_2275 | Is Drk essential for anesthesia-resistant memory (ARM) in Drosophila? | Anesthesia-resistant memory (ARM) was described decades ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memory inDrosophilaremain poorly understood. Whether the several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in one or more ... | yes |
converted_84 | Is valproic acid effective for glioblastoma treatment? | A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma., PURPOSE: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in precl... | yes |
converted_191 | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | This study reports the consequences of LT4 treatment over a prolonged period of time in 2 of the first patients with a heterozygous mutation in TRα1., Here we show that the dysregulation of the pituitary-thyroid axis was worsened by the lack of TR alpha1 in TR betaPV mice, and severe impairment of postnatal growth was ... | yes |
converted_2078 | Is the number of described human nuclear mutations less than 50000? | The number of known mutations in human nuclear genes, underlying or associated with human inherited disease, has now exceeded 100,000 in more than 3700 different genes (Human Gene Mutation Database)., The Human Gene Mutation Database (HGMD®) is a comprehensive collection of germline mutations in nuclear genes that unde... | no |
converted_1294 | Are optogenetics tools used in the study and treatment of epilepsy? | The emerging revolutionary technique of optogenetics enables manipulation of the activity of specific neuronal populations in vivo with exquisite spatiotemporal resolution using light. We used optogenetic approaches to test the role of hippocampal excitatory neurons in the lithium-pilocarpine model of acute elicited se... | yes |
converted_3965 | Is co-loss of BRCA2-RB1 associated with better prognosis for prostate cancer patients? | In human prostate cancer cell lines (LNCaP and LAPC4), loss of BRCA2 leads to the castration-resistant phenotype. Co-loss of BRCA2-RB1 in human prostate cancer cells induces an epithelial-to-mesenchymal transition, which is associated with invasiveness and a more aggressive disease phenotype. Importantly, PARP inhibito... | no |
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