id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
values |
|---|---|---|---|
converted_2721 | Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | . Brucellosis is a major cause of pyrexia of unknown origin (PUO), Brucellosis is the most common bacterial zoonosis, and causes a considerable burden of disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to infection with Brucella spp,, quite abruptly, he developed asthenia and... | no |
converted_3241 | Can Enlimomab improve stroke outcomes? | Treatment with a murine anti-ICAM-1 antibody (enlimomab) has been investigated in patients with acute ischemic stroke in the Enlimomab Acute Stroke Trial (EAST). Unfortunately, the case fatality rate in this trial was significantly higher in the enlimomab patient group than in the placebo group., The two clinical trial... | no |
converted_1848 | Is rucaparib used for ovarian cancer treatment? | While olaparib is the first PARP inhibitor to receive approval for ovarian cancer treatment, others including rucaparib and niraparib are clearly effective in this disease and, within the next year or two, the results of ongoing randomised trials will clarify their respective roles. , Similar trials with other PARP inh... | yes |
converted_3697 | Is SATB1 necessary for T-cell maturation? | Special AT-rich binding protein 1 (SATB1) nuclear protein, expressed predominantly in T cells, regulates genes through targeting chromatin remodeling during T-cell maturation., the transcription factor SATB1 that regulates the T-cell maturation, SATB1 is a transcriptional regulator controlling the gene expression that ... | yes |
converted_3240 | Can mitochondria transfer from cell to cell? | Interest in the recently discovered phenomenon of mitochondrial transfer between mammalian cells has gained momentum since it was first described in cell culture systems more than a decade ago., We show evidence that mitochondria transfer from Jurkat cells to MSCs, which is mediated by cell adhesion, This process of mi... | yes |
converted_1804 | Is RASA2 involved in melanoma? | Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated wit... | yes |
converted_3855 | Does IL18 signaling have a role in thymus? | IL18 signaling promotes homing of mature Tregs into the thymus., Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus., er, we show that IL18R+ T... | yes |
converted_2876 | Does tremelimumab improve survival of mesothelioma patients? | BACKGROUND: Tremelimumab, an anti-CTLA4 monoclonal antibody, initially showed good activity when used alone in patients with mesothelioma, but did not improve the overall survival of patients who failed on first-line or second-line chemotherapy compared with placebo in the DETERMINE study. , INTERPRETATION: The combina... | no |
converted_2226 | Is there any involvement of L1 retrotransposition in the Rett syndrome? | Using neuronal progenitor cells derived from human induced pluripotent stem cells and human tissues, we revealed that patients with Rett syndrome (RTT), carrying MeCP2 mutations, have increased susceptibility for L1 retrotransposition. Our data demonstrate that L1 retrotransposition can be controlled in a tissue-specif... | yes |
converted_4145 | Is atenolol metabolized by CYP2D6? | The study analysed the prescribing and dispensing of CYP2D6 drugs (metoprolol, donepezil, galantamine, codeine, tamoxifen) together with CYP2D6-blocking SSRIs (paroxetine/fluoxetine) or SSRIs without significant CYP2D6 inhibition (citalopram/escitalopram/sertraline), and the related prescribing of CYP2D6-independent co... | no |
converted_4413 | Is there a role for CADM1 in Myelodysplastic syndrome (MDS)? | Together with the frequent simultaneous deletions of KMT2A, ATM and CBL and mutations of ASXL1, SF3B1 and CBL, we show that CADM1 may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies., The CADM1 tumor suppressor gene is ... | no |
converted_220 | Has depression been shown to be a predictor of frailty? | significant role of frailty as a predictor of depression in a relatively younger old Chinese population, significant relationships between frailty and depressive symptoms and mortality at 1 year, These findings suggest that malnutrition is a major predictor of frailty or the "failure to thrive" syndrome in older person... | yes |
converted_649 | Is low T3 syndrome related with high BNP in cardiac patients? | BNP and fT3 are independently associated with exercise capacity in severely compromised HF patients., fter adjustment for known confounders, NT-pro-BNP was significantly associated with fT3 and low-T3 syndrome. fT3 (HR 0.58, 95%CI 0.34-0.98) and low-T3 syndrome (HR 3.0, 95%CI 1.4-6.3) were predictive for mortality afte... | yes |
converted_2618 | Can non ubiquitinated Tomm20 promote mitophagy? | A total of 338 new targets were identified and from these we validated glycogen synthase kinase 3β (Gsk3β), which can phosphorylate α-synuclein, and translocase of outer mitochondrial membrane 20 (Tomm20), a mitochondrial translocase that, when ubiquitinated, promotes mitophagy, as SCFFbxo7substrates both in vitro and... | no |
converted_821 | Is K-63 linked protein ubiquitination related to proteasomal degradation? | In contrast to K48-linked polyubiquitin chains, K63-linked polyubiquitin chains function in nonproteasomal biological processes., Modification of proteins by the addition of lysine (K)-63-linked polyubiquitin (polyUb) chains is suggested to play important roles in a variety of cellular events, including DNA repair, sig... | no |
converted_2657 | Are AAV vectors considered for the treatment of retinal dystrophies? | These novel gene vectors aim to more safely and efficiently transduce retinal cells, expand the gene packaging capacity of AAV, and utilize new strategies to correct the varying mechanisms of dysfunction found with inherited retinal dystrophies. | yes |
converted_2897 | Is lucatumumab a polyclonal antibody? | A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma., In this open-label, multicentre, phase 1 study a fully human anti-CD40 antagonist monoclonal antibody, lucatumumab, was evaluated in patients with ... | no |
converted_1103 | Is miR-21 related to carcinogenesis? | miR-21* and miR-203 were significantly dysregulated (P < 0.05) in PTC tissues with BRAFV600E., Expressions of miRNAs in papillary thyroid carcinoma and their associations with the BRAFV600E mutation., Levels of miRNA-21 (miR-21) and miR-106a in gastric cancer tissues were significantly higher compared with the levels i... | yes |
converted_2637 | Is there a disease or condition called Exploding Head Syndrome? | This case report describes the first-ever diagnosis of exploding head syndrome in a patient with longstanding epilepsy and novel nocturnal events. , Exploding head syndrome (EHS) is characterized by loud noises or a sense of explosion in the head during sleep transitions., Exploding head syndrome is characterized by th... | yes |
converted_4283 | Is AZD9668 a VEGF mRNA drug? | AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD., AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses of 60 mg bid during Phase I/IIa development. | no |
converted_1716 | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | Combined longitudinal analysis of the 2 cohorts suggests further association of several loci with Larsen score (KIF5A, PTPN22, AFF3, TAGAP) and therefore a significant accumulation of RA severity markers among RA susceptibility markers (p = 0.016), A non-intronic marker at TNFAIP3, GIN1/C5orf30, STAT4, ANKRD55/IL6ST, B... | yes |
converted_3925 | Are the major royal jelly proteins similar to the yellow proteins? | Major royal jelly proteins (named MRJP1-5) of honeybee (Apis mellifera), yellow proteins of Drosophila, together with putative proteins found in several bacteria, form a protein family termed the MRJP/yellow family., Analysis of Drosophila yellow-B cDNA reveals a new family of proteins related to the royal jelly protei... | yes |
converted_1176 | Is there an association between serum interleukin-6 concentrations and outcomes of stroke patients? | In addition, IL-6 concentrations affect clinical outcomes in ischemic stroke., After appropriate adjustment, the odds ratios for the association of markers and poor outcome (comparing the upper and the lower third) were interleukin-6, 3.1 (95% CI: 1.9-5.0); C-reactive protein, 1.9 (95% CI: 1.2-3.1); fibrinogen, 1.5 (9... | yes |
converted_3068 | Has the protein SIRT2 been associated to cervical cancer? | A progressive increase in the expression of both SIRT2 and SIRT7 was noted during cancer progression in the following order: normal < preneoplasia < cancer., We demonstrate that treatment of cervical cancer cells with a RhoGDIα-derived K52-trifluoroacetylated, substrate-derived peptidic sirtuin inhibitor severely imp... | yes |
converted_2140 | Is it feasible to obtain DNA read lengths that exceed 30 Kb? | Single-molecule, real-time sequencing (SMRT) developed by Pacific BioSciences produces longer reads than secondary generation sequencing technologies such as Illumina. The long read length enables PacBio sequencing to close gaps in genome assembly, reveal structural variations, and identify gene isoforms with higher ac... | no |
converted_673 | Does the protein mTOR regulate autophagy? | autophagy is negatively regulated by the mammalian target of rapamycin receptor (mTOR), Subjecting cells to starvation or rapamycin efficiently induces autophagy by inhibiting the MTOR signaling pathway triggering increased autophagic flux. , Several pathways, including mTOR, have been shown to regulate autophagy., the... | yes |
converted_4370 | Is hemoglobin antimicrobial? | the α137-141 peptide, a natural antimicrobial peptide, can be obtained after hydrolysis of hemoglobin, the main constituent of blood red part, Beyond its physiological activity, hemoglobins are able to inhibit the growth of several microorganisms., A novel AMP, T. granosa hemoglobin-derived peptide (TGH1), was identifi... | yes |
converted_1574 | Does the concentration of protein HIF-1α increase after the administration of the cytoprotective prodrug"amifostine" (ethyol) ? | We demonstrated that the treatment of several human cancer cell lines with therapeutical doses of WR-1065 led to a strong induction of different VEGF-A mRNA isoforms independently of HIF-1alpha, e investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and carbonic anh... | yes |
converted_1097 | Does thyroid hormone affect cardiac remodeling? | The aim of this brief paper is to highlight new developments in understanding the cardioprotective role of thyroid hormone in reverting regulatory networks involved in adverse cardiac remodeling., Thyroid hormone receptor α1 (TRα1) is shown to be critical for the maturation of cardiomyocytes and for the cellular respon... | yes |
converted_4629 | Is covid-19 induced anosmia caused by disruption of nuclear architecture? | Disruption of nuclear architecture as a cause of COVID-19 induced anosmia., Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory receptors (ORs) as well as key components... | yes |
converted_963 | Is STAT3 involved in EIF2AK2-dependent suppression of autophagy? | STAT3 may act as a competitive inhibitor of EIF2AK2. Indeed, pharmacological or genetic inhibition of STAT3 stimulates EIF2AK2-dependent EIF2S1 phosphorylation and autophagy. Conversely, the overexpression of wild-type STAT3 as well as of STAT3 mutants that cannot be phosphorylated by JAK2 or are excluded from the nucl... | yes |
converted_3465 | Are lamina-associated domains (LADs) associated with transcriptional activation? | Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains., Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes., Such lamina-associated dom... | no |
converted_1843 | Are deletions of chromosomal regulatory boundaries associated with congenital disease? | Deletions of chromosomal regulatory boundaries are associated with congenital disease., Our results suggest that enhancer adoption caused by deletions of regulatory boundaries may contribute to a substantial minority of copy-number variation phenotypes and should thus be taken into account in their medical interpretati... | yes |
converted_1432 | Do U6-associated proteins Lsm4 and Lsm6 interact with SMN? | SMN also interacts with at least two of the U6-associated Sm-like (Lsm) proteins, Lsm4 and Lsm6. , Interestingly, SMN also interacts with at least two of the U6-associated Sm-like (Lsm) proteins, Lsm4 and Lsm6, Furthermore, we present evidence for two separate binding sites in SMN for Sm/Lsm proteins., Interestingly, S... | yes |
converted_3193 | Is the Philadelphia chromosome a fusion between parts of chromosomes 1 and 9? | The Philadelphia chromosome, t(9;22)(q34;q11), is present in 95% of CML patients, resulting in constitutive tyrosine kinase activity; however, ~5% of CML patients possess a Philadelphia variant. , Chronic Myeloid Leukemia (CML) is myeloproliferative neoplasm characterized by Philadelphia chromosome which is a balanced... | no |
converted_1265 | Are there any animal models for Niemann-Pick C1 disease? | Several animal models were used to analyze the impaired pathways. , We investigated components of the surfactant system in both NPC1 mutant mice and felines and in NPC2 mutant mice near the end of their expected life span. , Thus far, studies of NPC mice have been performed mainly to study the brain and neurodegenerati... | yes |
converted_2005 | Is Doxorubicin cardiotoxic? | Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage. , The results provide direct evidence for the role of catalase in doxorubicin cardiotoxic responses., These results do not support the possibility t... | yes |
converted_1917 | Is there a role for gamma knife in treatment of Obsessive-Compulsive Disorder? | OBJECTIVE Functional Gamma Knife radiosurgery (GKRS) procedures have been increasingly used for treating patients with tremor, trigeminal neuralgia (TN), and refractory obsessive-compulsive disorder., METHODS The authors constructed a linear-quadratic model of BED in functional GKRS with a dose-protraction factor to co... | yes |
converted_4463 | Is EuroQol 5-Dimension Health Assessment (EQ-5D) [a widely used, simple instrument that monitors the general health-related quality of life (HRQoL) in chronic disease] a 5 question assessment? | The 6-question EuroQol 5-Dimension Health Assessment (EQ-5D) is a widely used, simple instrument that monitors general health-related quality of life (HRQoL) in chronic disease. , OBJECTIVE: The 6-question EuroQol 5-Dimension Health Assessment (EQ-5D) is a widely used, simple instrument that monitors general health-rel... | no |
converted_4488 | Is Algenpantucel-L effective for pancreatic cancer? | Median (IQR) overall survival was 14.9 (12.2-17.8) months in the standard group (N=158) and 14.3 (12.6-16.3) months in the experimental group (N = 145) (hazard ratio [HR] 1.02, 95% CI 0.66-1.58; P = 0.98). Median progression-free survival was 13.4 months in the standard group and 12.4 months in the experimental group ... | no |
converted_2267 | Is there any role of 5hmC in T-cell development and differentiation? | We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell differentiation in the periphery. We show that 5hmC is enriched in the gene body of highly expressed genes at all developmental stages and that its presence correlates positively with gene expression. Furthe... | yes |
converted_1823 | Is Annexin V an apoptotic marker? | The apoptosis of the MSCs was induced by subjecting the cells to OGD conditions for 4 h and was detected by Annexin V/PI and Hoechst 33258 staining. , In addition to the antimicrobial activity, we found that treatment of the cancer cell lines, Jurkat T-cells, Granta cells, and melanoma cells, with the Pseudomonas sp. I... | yes |
converted_222 | Is there any association between Jarid2 and miR-155 in Th17 cells? | Jarid2 links MicroRNA and chromatin in Th17 cells., In this issue of Immunity, Escobar et al. (2014) bring microRNAs and chromatin together by showing how activation-induced miR-155 targets the chromatin protein Jarid2 to regulate proinflammatory cytokine production in T helper 17 cells., miR-155 activates cytokine gen... | yes |
converted_4558 | Do mutations in KCNT2 only cause phenotypes with epilepsy? | KCNT2 variants resulting in substitutions affecting the Arg190 residue have been shown to cause epileptic encephalopathy and a recognizable facial gestalt. We report two additional individuals with intellectual disability, dysmorphic features, hypertrichosis, macrocephaly and the same de novo KCNT2 missense variants af... | no |
converted_1231 | Is EZH2 associated with prostate cancer? | The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells, EZH2 plays an active role in this process by repressing the expression of TIMP2 and TIMP3 in prostate cancer cells, The TIMP genes are derepressed by knockdown of EZH2 expression in human prostate cancer cells but ... | yes |
converted_409 | Does a linker histone exist in the yeast genome? | Hho1p is a bona fide linker histone, In Saccharomyces cerevisiae, HHO1 encodes a putative linker histone with very significant homology to histone H1, HHO1p may play a similar role to linker histones, but at restricted locations in the chromatin, The putative linker histone in Saccharomyces cerevisiae, Hho1p, has two r... | yes |
converted_2794 | Are ultraconserved enhancers important for normal development? | Ultraconserved Enhancers Are Required for Normal Development., However, initial deletion studies in mice revealed that loss of such extraordinarily constrained sequences had no immediate impact on viability. Here, we show that ultraconserved enhancers are required for normal development. , Here, we show that ultraconse... | yes |
converted_488 | Can exosomes be detected in urine? | Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the plasma membrane. The molecular content of exosomes is a fingerprint of the releasing cell type and of its status. For this reason, and because they are released in easily accessible body fluids such as blood and ... | yes |
converted_3284 | Do de novo truncating mutations in WASF1 cause cancer? | De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures., Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in five unrelated individuals with moderate to profound intellectual disability with autis... | no |
converted_1544 | Could Hyperthermic intraperitoneal chemotherapy (HIPEC) be effective for the treatment of recurrent ovarian cancer? | The use of HIPEC after aggressive cytoreductive surgery in patients with ovarian cancer with peritoneal dissemination can be performed with acceptable postoperative morbidity rates. Knowledge of the factors associated with the onset of these postoperative adverse events allows better management of the same and offers t... | yes |
converted_4032 | Is G3BP1 found in stress granules? | RAS GTPase-activating protein-binding protein (G3BP1) is an RNA-binding protein that is essential for assembling stress granules. , Within SGs, single-molecule localization microscopy revealed distributed hotspots of immobilized G3BP1 and IMP1 that reflect the presence of relatively immobile nanometer-sized nanocores.,... | yes |
converted_88 | Is fatigue prevalent in patients receiving treatment for glioblastoma? | By contrast, fatigue worsened over time, with a difference in mean score of 5.6 points between baseline and 4-month follow-up (P=.02)., In the GB cohort, the most common side effects were fatigue (56 %), diarrhea (44 %), neutropenia (31 %), and thrombocytopenia (25 %). , A total of 37 patients were treated, and treatme... | yes |
converted_3070 | Are recessive coding variants responsible for the majority of undiagnosed nonconsanguineous individuals? | Our results suggest that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration. | no |
converted_2060 | Do brown fat cells produce heat? | WAT and BAT are both involved in energy balance. WAT is mainly involved in the storage and mobilization of energy in the form of triglycerides, whereas BAT specializes in dissipating energy as heat during cold- or diet-induced thermogenesis., Because brown adipose tissue (BAT) dissipates energy in the form of heat, inc... | yes |
converted_1519 | Does nifedipine inhibit L-type calcium channels? | Nifedipine, an L-type calcium channel blocker, reduced the expression of synaptogamin and syntaxin and blocked the suppressive effect of vecuronium, suggesting that both agents inhibit presynaptic L-type calcium channels., Treatment with nifedipine to inhibit calcium influx via the L-type channel Cav1.2 (alpha(1C)) inh... | yes |
converted_747 | Is Hirschsprung disease one of the characteristics of the Mowat-Wilson syndrome? | Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung diseas... | yes |
converted_2071 | Has the gorilla genome been determined? | Starting with human, chimpanzee, gorilla, and orangutan genomes, our software generated an exhaustive data set of 292 ALs (∼1 kb each) in ∼3 h. , We generated a high-quality assembly of the gorilla genome using single-molecule, real-time sequence technology and a string graph de novo assembly algorithm, Here we present... | yes |
converted_4075 | Has AZD9668 been tested in clinical trials? | Efficacy, safety and tolerability of AZD9668 (5, 20 and 60 mg bid) were compared with placebo in a randomised, double-blind, placebo-controlled, 12-week, Phase IIb trial (NCT00949975: approved by an Investigational Review Board), in patients with symptomatic COPD receiving maintenance tiotropium. , A randomised, placeb... | yes |
converted_2232 | Is there any role of TBR1 in autism? | TBR1 regulates autism risk genes in the developing neocortex, Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including TBR1, a master regulator of cortical development. We performed ChIP-seq for TBR1 during m... | yes |
converted_3656 | Can Systemic Lupus Erythematosus cause seizures? | The mean ± SD age at SLE diagnosis and at onset of PRES was 25.02 ± 13.78 and 28.31 ± 12.61 years, respectively. Seizure was the most common presenting symptom, as seen in 28 episodes, followed by acute severe headache in 17,, Epilepsy is characterized by a relevant epidemiological and clinical burden. In the extant li... | yes |
converted_3145 | Can TAD disruption lead to disease? | its perturbation will lead to human disease, highlighting the accumulating evidence that links the diverse 3D genome architecture components to a multitude of human diseases and the emerging mechanisms by which 3D genome derangement causes disease phenotypes., TAD boundaries are insulators of genomic neighborhoods. In ... | yes |
converted_2423 | Is Solanezumab effective for Alzheimer's Disease? | An analysis of publicly available data from the Phase II studies for bapineuzumab and solanezumab indicates that neither compound produced compelling evidence of drug-like behavior that would justify their progression into pivotal trials. , Notably, a recent study of solanezumab, an amyloid β monoclonal antibody, raise... | no |
converted_1717 | Is marijuana use associated with increased risk for stroke? | The illicit drugs more commonly associated with stroke are psychomotor stimulants, such as amphetamine and cocaine. Less commonly implicated are opioids and psychotomimetic drugs, including cannabis., Among 326 patients (184 males), the most frequent stroke risk factors overall were dyslipidaemia (187), smoking (161), ... | yes |
converted_1343 | Are conserved noncoding elements associated with the evolution of animal body plans? | Here, we discuss the evidence that CNEs are part of the core gene regulatory networks (GRNs) that specify alternative animal body plans. The major animal groups arose>550 million years ago. We propose that the cis-regulatory inputs identified by CNEs arose during the "re-wiring" of regulatory interactions that occurred... | yes |
converted_2671 | Is a mutation of the ZIKV's membrane protein prM responsible for the microcephaly in new-born infants? | Here we show that a single serine-to-asparagine substitution [Ser139→Asn139(S139N)] in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice., A sing... | yes |
converted_1964 | Is there any involvement of the long non-coding RNA Gomafu in schizophrenia? | The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing., Here, we profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically regulated by neuronal activation, including acute downregula... | yes |
converted_3695 | Are Chernobyl survivors at increased risk for breast cancer? | Results: A more aggressive course of breast cancer is observed in patients exposed to radiation from the Chernobyl accident under the age of 30 years (P < .01). , A significant excess of multiple myeloma incidence [standardized incidence rate (SIR) 1.61 %, 95% confidence interval (CI) 1.01-2.21], thyroid cancer (SIR 4.... | yes |
converted_4694 | Are there any R packages that help with visualizing data on spirals? | spiralize: an R package for Visualizing Data on Spirals., Spiral layout has two major advantages for data visualization. First, it is able to visualize data with long axes, which greatly improves the resolution of visualization. Second, it is efficient for time series data to reveal periodic patterns. Here we present t... | yes |
converted_3830 | Should tirilazad be used for treatment of ischemic stroke? | CONCLUSION: Tirilazad had no effect on clinical outcome but did decrease symptomatic vasospasm in five trials of aneurysmal SAH. , Tirilazad did not significantly decrease unfavorable clinical outcome on the GOS (odds ratio [OR] 1.04, 95% confidence interval [CI] 0.89-1.20) or cerebral infarction (OR 1.04, 95% CI 0.89-... | no |
converted_3033 | Is there a link between BCL11B haploinsufficiency and syndromic neurodevelopmental delay? | BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells., Using massively parallel sequencing we identified 13 patients bearing heterozygous germline alterations in BCL11B. Notably, all of them are affected by global developmental delay with speech impairment and... | no |
converted_4300 | Is istiratumab effective for pancreatic cancer? | CONCLUSIONS: Istiratumab failed to improve the efficacy of SOC chemotherapy in this patient setting. | no |
converted_3777 | Does protein ALEX1 contain armadillo repeats? | ALEX1 (Arm protein lost in epithelial cancers, on chromosome X), contains two armadillo repeats domains, is expressed different in normal and carcinomas tissues., Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) is a novel member of the Armadillo family which has two Armadillo repeats as opposed to mor... | yes |
converted_3216 | Is collagen matrix of human articular cartilage changing with disease? | The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease., the chondrocytes in ageing articular cartilage have limited capacity to turnover the interterritorial matrix., Type II collagen is a major component of... | no |
converted_2798 | Is Tecovirimat effective for smallpox? | Oral Tecovirimat for the Treatment of Smallpox., CONCLUSIONS: On the basis of its efficacy in two animal models and pharmacokinetic and safety data in humans, tecovirimat is being advanced as a therapy for smallpox in accordance with the FDA Animal Rule., Background: Tecovirimat (ST-246) is being developed as an antivi... | yes |
converted_4703 | Does sphingosine-1 phosphoate suppress epiregulin? | S1P-induced FOXO1 and EREG gene expression suggests that the activation of S1P-S1PR axis may cooperate with gonadotropins in modulating follicle development., S1P-dependent CREB phosphorylation induced FOXO1 and the EGF-like epiregulin-encoding gene (EREG), confirming the exclusive role of gonadotropins and interleukin... | no |
converted_3132 | Can you computationally predict Molecular Recognition Features (MoRFs) regions in Intrinsically Disordered Proteins (IDPs)? | Predicting Functions of Disordered Proteins with MoRFpred., Intrinsically disordered proteins and regions are involved in a wide range of cellular functions, and they often facilitate protein-protein interactions. Molecular recognition features (MoRFs) are segments of intrinsically disordered regions that bind to partn... | yes |
converted_299 | Has the protein SETMAR (Metnase) a transposase domain? | Metnase (SETMAR) is a SET-transposase fusion protein that promotes nonhomologous end joining (NHEJ) repair in humans., The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations., Metnase (also termed SETMAR) is a fusion of a histone methylase and transposase protein that arose specifically in... | yes |
converted_3510 | Are there interactions between short and long noncoding RNAs? | It is now evident that noncoding RNAs play key roles in regulatory networks determining cell fate and behavior, in a myriad of different conditions, and across all species. Among these noncoding RNAs are short RNAs, such as MicroRNAs, snoRNAs, and Piwi-interacting RNAs, and the functions of those are relatively well un... | yes |
converted_1556 | Is CHEK2 involved in cell cycle control? | Moreover, cell-cycle progression genes [i.e. E2F transcription factor (E2F) family and histone deacetylase ( HDAC )] and DNA-repair genes [i.e. growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased., As CHEK2 is a cell-cycle master contro... | yes |
converted_1941 | Is NSD-1015 an inhibitor of Aromatic L-Amino Acid Decarboxylase? | When pretreated with a central AADC inhibitor (NSD-1015), further application of l-dopa failed to increase the motoneuron activity although the expression of DA in the AADC cells was not completely inhibited. , Inhibition of Ddc by AADC inhibitor NSD-1015 or anti-sense morpholino oligonucleotides (MO) reduced brain vol... | yes |
converted_471 | Is there a crystal structure of the full-length of the flaviviridae NS5(Methyltransferase - RNA depended RNA Polymerase) ? | flavivirus NS5 harbors a methyltransferase (MTase) in its N-terminal ≈ 265 residues and an RNA-dependent RNA polymerase (RdRP) within the C-terminal part. One of the major interests and challenges in NS5 is to understand the interplay between RdRP and MTase as a unique natural fusion protein in viral genome replicatio... | yes |
converted_3506 | Is mesothelioma caused by asbestos exposure? | Malignant mesothelioma is a rare and aggressive pleural or peritoneal tumour almost always caused by exposure to asbestos fibres, Exposure to asbestos can cause malignant mesothelioma 30-40 years after exposure., Malignant peritoneal mesothelioma is a rare, aggressive tumor arising from the peritoneal lining, induced b... | yes |
converted_4540 | Do only changes in coding regions of MEF2C cause developmental disorders? | Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms., Clinical genetic testing of protein-coding regions identifies a likely causative variant in only around half of developmental disorder (DD) cases. The contribution of regulatory variatio... | no |
converted_4543 | Is CircRNA produced by back splicing of exon, intron or both, forming exon or intron circRNA? | CircRNAs are a subclass of lncRNAs that have been found to be abundantly present in a wide range of species, including humans. CircRNAs are generally produced by a noncanonical splicing event called backsplicing that is dependent on the canonical splicing machinery, giving rise to circRNAs classified into three main ca... | yes |
converted_581 | Is CD99 encoded by MIC2 gene? | We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6, We obtained the final diagnosis of ES/PNET by immunohistochemical molecular study with positive staining for the MI... | yes |
converted_529 | Is TALEN being used on stem cells? | Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9., Genetic correction of patient-derived induced pluripotent stem cells (iPSCs) by TALENs or CRISPR-Cas9 holds promise for DMD gene therapy; however, the safety of such nuclease treatm... | yes |
converted_2136 | Is Cri Du Chat associated with an expansion of a repeat with in the gene found on chromosome 5? | Cri-du-chat syndrome is a chromosomal disorder caused by a deletion of the short arm of chromosome 5, The typical cri du chat syndrome, due to 5p15.2 deletion, includes severe intellectual disability, facial dysmorphisms, neonatal hypotonia and pre- and post-natal growth retardation, whereas more distal deletions in 5p... | no |
converted_3003 | Is verubecestat effective for Alzheimer’s Disease? | The lack of efficacy of verubecestat in mild-to-moderate AD raises important questions about the timing of intervention with BACE-1 inhibitors, and anti-amyloid therapies in general, in AD treatment., This reaction was applied to the preparation of verubecestat, which is currently undergoing clinical evaluation for th... | no |
converted_4478 | Is Phospholemman a membrane protein? | the transmembrane lipoprotein phospholemman (FXYD1), Phospholemman (FXYD1) is a single-transmembrane protein regulator of Na,K-ATPase, expressed strongly in heart, skeletal muscle, and brain and phosphorylated by protein kinases A and C at Ser-68 and Ser-63, respectively., We previously identified FXYD1 (encoding phos... | yes |
converted_462 | Does melanoma occur in people of African origin ? | ALM is the most common type of melanoma amongst Asians, Africans,, ALM develops on palmar, plantar, and subungual skin, and its biology is different from that of other cutaneous melanomas, where sunlight is the major known environmental determinant, We present four albinos with histologic diagnoses of skin cancer, Four... | yes |
converted_4429 | Is vocimagene amiretrorepvec effective for recurrent high-grade glioma? | Relevance: Among patients who underwent tumor resection for first or second recurrence of glioblastoma or anaplastic astrocytoma, administration of Toca 511 and Toca FC, compared with SOC, did not improve overall survival or other efficacy end points., The median OS was 11.10 months for the Toca 511/FC group and 12.22 ... | no |
converted_1173 | Do Parkinson's disease patients experience stridor? | The authors describe a patient experiencing stridor and dysphagia with confirmed pulmonary restriction and aspiration following subthalamic nucleus deep brain stimulator adjustment, with a resolution of symptoms and signs when the stimulator was switched off., Stridor was not noted during sleep at night. Endoscopic exa... | yes |
converted_785 | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder., Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.... | yes |
converted_2190 | Is there an association between Histone H3.3 mutations and glioma? | PURPOSE: Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas. We report a case of thalamic glioma with H3F3A K27M mutation,... | yes |
converted_2792 | Is celecoxib effective for treatment of amyotrophic lateral sclerosis? | NTERPRETATION: At the dosage studied, celecoxib did not have a beneficial effect on research subjects with ALS, and it was safe. A biological effect of celecoxib was not demonstrated in the cerebrospinal fluid. Further studies of celecoxib at a dosage of 800 mg/day in ALS are not warranted., Prostaglandin E(2) levels i... | no |
converted_1165 | Are there currently applications of deep learning in genomics? | Deep learning of the tissue-regulated splicing code., Using a deep neural network, we developed a model inferred from mouse RNA-Seq data that can predict splicing patterns in individual tissues and differences in splicing patterns across tissues. Our architecture uses hidden variables that jointly represent features in... | yes |
converted_2370 | Can the yeast protein Abf1 act as insulator? | Saccharomyces cerevisiae Rap1p and Abf1p proteins are endowed with a potent insulating capacity, Insulating domains in Rap1p coincide with previously described transcription activation domains, whereas four adjacent subdomains spanning the whole of the Abf1p C terminus (440-731) were found to display autonomous insulat... | yes |
converted_2781 | Is Bobble head doll syndrome associated with hydrocephalus? | The first is a 14-year-old boy with BHDS associated with aqueductal obstruction and triventricular hydrocephalus secondary to a tectal tumor., Brain magnetic resonance imaging showed a large suprasellar arachnoid cyst extending into the third ventricle, with obstructive hydrocephalus, characteristic of bobble-head doll... | yes |
converted_1695 | Is calcium overload involved in the development of diabetic cardiomyopathy? | High-glucose treatment resulted in increased intracellular calcium ([Ca2+]i) which was mobilized to the mitochondria. Concomitant intra-mitochondrial calcium ([Ca2+]m) increase resulted in enhanced reactive oxygen and nitrogen species generation. These events led to mitochondrial dysfunction and apoptosis., The novel f... | yes |
converted_809 | Are conserved noncoding elements associated with developmental genes? | Some characteristics of CNEs include their high frequency in mammalian genomes, their potential regulatory role in gene expression, and their enrichment in gene deserts nearby master developmental genes, we review recent findings that disruptions of CNEs, within or at long distance from the coding sequences of key gene... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.