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10.1093/nar/gku578
Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance pathway that recognizes mRNAs with premature stop codons and targets them for rapid degradation. Evidence from previous studies has converged on UPF1 as the central NMD factor. In human cells, the SMG1 kinase phosphorylates UPF1 at the N-terminal and C-ter...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1109/TBME.2018.2813015
Uncertainty Aware Organ Classification For Surgical Data Science Applications In Laparoscopy
Objective: Surgical data science is evolving into a research field that aims to observe everything occurring within and around the treatment process to provide situation-aware data-driven assistance. In the context of endoscopic video analysis, the accurate classification of organs in the field of view of the camera pr...
[ "Computer Science and Informatics", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1038/ng.2293
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at...
[ "Integrative Biology: from Genes and Genomes to Systems", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
341089
Understanding the roles of kainate receptors in the hippocampus
Kainate receptors (KARs) are often regarded as the last frontier of glutamate receptor research, since much less is known about their physiological roles compared with that of the other glutamate receptor subtypes. This field of research is very important not just because of the unique role that KARs play in neuronal f...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1128/microbiolspec.MDNA3-0061-2014
The influence of LINE-1 and SINE retrotransposons on mammalian genomes
Transposable elements have had a profound impact on the structure and function of mammalian genomes. The retrotransposon Long INterspersed Element-1 (LINE-1 or L1), by virtue of its replicative mobilization mechanism, comprises ~17% of the human genome. Although the vast majority of human LINE-1 sequences are inactive ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
interreg_2001
Central European SME Gateway to Key-enabling Technology Infrastructures - Sparking a new Transnational KET Innovation Ecosystem
CE as model region for an access & service network for SME to bring smart solutions from idea to market readiness Smart solutions derive from applying key enabling technologies (KET) such as micro-nanoelectronics or optical techn. compounds and advanced materials and thus lifting products, processes and services to a n...
[ "Products and Processes Engineering", "Materials Engineering", "Systems and Communication Engineering" ]
10.1002/anie.201311024
Iron-catalyzed C(sp<sup>2</sup>)-H and C(sp<sup>3</sup>)-H arylation by triazole assistance
Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. ...
[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
W1978315522
Highly Diastereoselective Samarium Diiodide Induced Ketyl Cyclisations of Indole and Pyrrole Derivatives - Scope and Limitations
Here we summarise our results for SmI2-induced 5-exo-trig to 8-exo-trig reductive cyclisations of suitably substituted indole and pyrrole derivatives. All precursors were easily prepared by simple N-alkylation or N-acylation of indole and pyrrole derivatives with the corresponding iodo alkanones, acid chlorides or lact...
[ "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences" ]
W1991997530
Towards “mouldable code” via nested code graph transformation
Program transformation is currently de facto restricted to abstract syntax tree rewriting. However, many program transformation patterns, in particular in the realm of high-performance code generation, can more naturally be understood and expressed as graph transformations. We describe the conceptual organisation of a ...
[ "Computer Science and Informatics", "Mathematics" ]
10.1016/j.gca.2017.09.005
Differentiation and magmatic activity in Vesta evidenced by <sup>26</sup>Al-<sup>26</sup>Mg dating in eucrites and diogenites
The 26Al-26Mg short-lived chronometer has been widely used for dating ancient objects in studying the early Solar System. Here, we use this chronometer to investigate and refine the geological history of the asteroid 4-Vesta. Ten meteorites widely believed to come from Vesta (4 basaltic eucrites, 3 cumulate eucrites an...
[ "Universe Sciences", "Earth System Science" ]
10.1182/blood.2020006738
Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency
Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of immunity (IEIs) characterized predominantly by Epstein-Barr virus (EBV)-associated immune dysregulation, such as chronic viremia, severe infectious mononucleosis, hemophagocytic lymphohistiocytosis (HLH), lymphoproliferation, an...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1029/2012GL052002
Comparison Of Ray And Adjoint Based Sensitivity Kernels For Body Wave Seismic Tomography
[1] We compare finite-frequency sensitivity kernels computed from ray-theoretical wavefields (“banana-doughnut” kernels) and from full waveform computations (often called “adjoint” kernels) in order to evaluate resolution, accuracy and computational cost. We focus here on body-wave seismic tomography at regional and lo...
[ "Earth System Science", "Mathematics" ]
10.18632/oncotarget.14895
The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types
For many years, defects in the ribosome have been associated to cancer. Recently, somatic mutations and deletions affecting ribosomal protein genes were identified in a few leukemias and solid tumor types. However, systematic analysis of all 81 known ribosomal protein genes across cancer types is lacking. We screened m...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Physiology in Health, Disease and Ageing" ]
10.1364/OE.17.019926
Terahertz Ambipolar Dual Wavelength Quantum Cascade Laser
Terahertz frequency quantum cascade lasers (THz QCLs) are compact solid-state sources of terahertz radiation that were first demonstrated in 2002. They have a broad range of potential applications ranging from gas sensing and non-destructive testing, through to security and medical imaging, with many polycrystalline co...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
10.1016/j.cell.2017.08.018
Mitochondrial Priming by CD28
T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that, upon T cell activation, CD28 transiently promotes expression of carnitine palmitoyltransferase 1a (Cpt1a), an en...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
788185
Artificial designer materials
Constructing designer materials where the atomic geometry, interactions, magnetism and other relevant parameters can be precisely controlled is becoming reality. I will reach this aim by positioning every atom with the tip of a scanning probe microscope, or by using molecular self-assembly to reach the desired structur...
[ "Condensed Matter Physics", "Materials Engineering", "Synthetic Chemistry and Materials" ]
10.1080/10564934.2016.1248231
Teachers In Schools With Low Socioeconomic Composition Are They Really That Different
This article aims to assess whether differences in teacher characteristics vary with differences in socioeconomic compositions of schools. We conducted correlation analyses on administrative data from the French-speaking education system in Belgium. This database regroups more than 20,000 teachers in 1,630 elementary s...
[ "The Social World and Its Interactions" ]
W2769674793
Experimental validation of plastic constitutive hardening relationship based upon the direction of the Net Burgers Density Vector
Abstract We present a new methodology for experimental validation of single crystal plasticity constitutive relationships based upon spatially resolved measurements of the direction of the Net Burgers Density Vector, which we refer to as the β -field. The β -variable contains information about the active slip systems a...
[ "Condensed Matter Physics", "Materials Engineering" ]
10.1016/j.polymer.2010.03.032
Kinetics of thermally-induced conformational transitions in soybean protein films
The thermally-induced conformational transitions of soybean protein films were studied as the films were heated under isothermal conditions in the range 40-100 °C. By comparing the kinetics of protein-water interactions as a function of temperature using time-resolved Fourier transform infrared (FTIR) spectroscopy, the...
[ "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
W1996994431
P-1229 - The effect of premorbid function on symptoms severity in first - episode of schizophrenia: an egyptian study
Introduction Psychiatric research focuses on development of psychosis and first- episode schizophrenia, early detection and Premorbid adjustment are of interest because it may reduce the heterogeneity of the disorder and may have predictive value. Aim To study the Premorbid functioning in first episode schizophrenic pa...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1016/j.colsurfb.2012.06.028
Thin phosphatidylcholine films as background surfaces with further possibilities of functionalization for biomedical applications
Non-specific adsorption is a crucial problem in the biomedical field. To produce surfaces avoiding this phenomenon, we functionalized thin (7-180. nm) poly(methylhydrosiloxane) (PMHS) network films at room temperature (≈20. °C) with phospholipids (PL) bearing a phosphorylcholine head. Regardless of their mode of prepa...
[ "Materials Engineering", "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences" ]
W2058710384
P.6.7 Wide phenotypic spectrum of SMA with lower limbs predominance due to mutations in the tail domain of DYNC1H1 gene: A case series
A relatively common neurogenic condition is the autosomal dominant congenital Spinal Muscular Atrophy, mainly affecting the lower limbs (SMA-LED). A proportion of patients with SMA-LED carry mutations in the tail domain of the Cytoplasmic Dynein Heavy Chain 1 (DYNC1H1). Mutations located in the same DYNC1H1 domain have...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1016/j.jpubeco.2017.09.002
Durable coalitions and communication: Public versus private negotiations
We present a laboratory experiment to study the effect of communication on durable coalitions — coalitions that support the same allocation from one period to the next. We study a bargaining setting where the status quo policy is determined by the policy implemented in the previous period. Our main experimental treatme...
[ "Individuals, Markets and Organisations", "The Social World and Its Interactions" ]
10.1039/C1JM10197H
Janus Particle Arrays With Multiple Structural Controlling Abilities Synthesized By Seed Directed Deposition
Janus particle arrays have attracted much investigation interest in recent years due to their wide application potentialities. Here, we introduce a new protocol to synthesize Janus particle arrays depending on seed-directed eletrophoretic deposition on monolayer colloidal crystal (MCC) templates. The size and feature o...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics", "Materials Engineering" ]
10.1080/08905495.2017.1335157
Women Editors And The Rise Of The Illustrated Fashion Press In The Nineteenth Century
In the second half of the nineteenth century, a new type of magazine emerged in Europe and the United States. Fashion—a staple of up-market women’s periodicals since the late eighteenth century—was. . .
[ "Texts and Concepts", "The Study of the Human Past", "Studies of Cultures and Arts" ]
W2151412165
Do iPads promote symbolic understanding and word learning in children with autism?
The use of the Apple iPad has skyrocketed in educational settings, along with largely unsubstantiated claims of its efficacy for learning and communication in children with autism spectrum disorder (ASD). Here, we examine whether children with ASD are better able to learn new word-referent relations using an iPad or a ...
[ "The Human Mind and Its Complexity", "Neuroscience and Disorders of the Nervous System" ]
W2940737966
High-Performance Defunctionalisation in Futhark
General-purpose massively parallel processors, such as GPUs, have become common, but are difficult to program. Pure functional programming can be a solution, as it guarantees referential transparency, and provides useful combinators for expressing data-parallel computations. Unfortunately, higher-order functions cannot...
[ "Computer Science and Informatics" ]
10.1177/0956797619842550
Rationality In Joint Action Maximizing Coefficiency In Coordination
When people perform simple actions, they often behave efficiently, minimizing the costs of movement for the expected benefit. The present study addressed the question of whether this efficiency scales up to dyads working together to achieve a shared goal: Do people act efficiently as a group (i. e. , coefficiently), or...
[ "The Human Mind and Its Complexity", "The Social World and Its Interactions" ]
715767
MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling
While access to 3D-printing technology becomes ubiquitous and provides revolutionary possibilities for fabricating complex, functional, multi-material objects with stunning properties, its potential impact is currently significantly limited due to the lack of efficient and intuitive methods for content creation. Existi...
[ "Computer Science and Informatics", "Materials Engineering", "Products and Processes Engineering" ]
W1906279513
Practical considerations in parasite control programmes for cats and dogs
Parasite control is required for a number of parasites infecting cats and dogs, both for animal and human health. Pet owners may obtain information from many sources such as pet shops, pharmacies, the internet and word of mouth, which can lead to confusion over which parasites are of concern and what control measures a...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases" ]
225624
High speed afm imaging of molecular processes inside living cells
Imaging the inside of living cells with single nanometre resolution has been a long-standing dream in bio-microscopy. Direct observation of changes to molecular networks inside of living cells would revolutionize the way we study structural cell biology. Unfortunately, no such tool exists. Atomic force microscopy (AF...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Condensed Matter Physics", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W611278037
The Challenge of Safeguards in the WTO
The Challenge of Safeguards in the WTO provides a comprehensive overview of the safeguard mechanism in the multilateral trading system. It explains at length its historical and conceptual foundations and elaborates on the various requirements for the imposition of safeguards and the conduct of safeguard investigations....
[ "Institutions, Governance and Legal Systems", "Individuals, Markets and Organisations" ]
10.1103/PhysRevA.96.013406
Efficient production of long-lived ultracold Sr2 molecules
We associate Sr atom pairs on sites of a Mott insulator optically and coherently into weakly bound ground-state molecules, achieving an efficiency above 80%. This efficiency is 2. 5 times higher than in our previous work [S. Stellmer, B. Pasquiou, R. Grimm, and F. Schreck, Phys. Rev. Lett. 109, 115302 (2012)PRLTAO0...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
10.1142/9789811207402_0028
Search For New Physics Via Baryon Edm At Lhc
Permanent electric dipole moments (EDMs) of fundamental particles provide powerful probes for physics beyond the Standard Model. We propose to search for the EDM of strange and charm baryons at LHC, extending the ongoing experimental program on the neutron, muon, atoms, molecules and light nuclei. The EDM of strange $Λ...
[ "Fundamental Constituents of Matter" ]
10.1088/1742-6596/473/1/012022
Performance Of Simulated Annealing In P Spin Glasses
We perform careful numerical simulations of slow Monte-Carlo annealings in the dense 3-body spin glass model and compare with the predictions from different theories: thresholds states, isocomplexity, following state. We conclude that while isocomplexity and following state both provide excellent agreement the numerica...
[ "Condensed Matter Physics", "Computer Science and Informatics" ]
10.1088/1741-2552/14/1/014001
Extracellular Matrix Proteins As Temporary Coating For Thin Film Neural Implants
Objective. This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i. e. microelectrocorticographic (µECOG) implants. Approach. Thin-film polyim...
[ "Materials Engineering", "Neuroscience and Disorders of the Nervous System", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1103/PhysRevB.84.104527
Decoherence, Autler-Townes effect, and dark states in two-tone driving of a three-level superconducting system
We present a detailed theoretical analysis of a multilevel quantum system coupled to two radiation fields and subject to decoherence. We concentrate on an effect known from quantum optics as Autler-Townes splitting, which has been recently demonstrated experimentally in a superconducting phase qubit. In the three-level...
[ "Condensed Matter Physics", "Fundamental Constituents of Matter" ]
10.1038/mi.2014.70
CCR2 + CD103 - Intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells
The identification of intestinal macrophages (ms) and dendritic cells (DCs) is a matter of intense debate. Although CD103 + mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103 - MPs remain controversial. We show here that intestinal CD103 - CD11b + MPs can be separated clearly into DC...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W1549972920
Route selection algorithm for Blind pedestrian
The vast majority of existing route selection processes is designed for vehicle navigation. In this paper we describe an adapted routing algorithm for visually impaired pedestrians based on users needs. Our aim was to find the most adapted route that connects origin and destination points, and which can provide the Bli...
[ "Computer Science and Informatics", "Systems and Communication Engineering", "Human Mobility, Environment, and Space" ]
W1974278211
Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice
Cystinuria is an autosomal recessive disease caused by mutations in SLC3A1 ( rBAT) and SLC7A9 ( b 0,+ AT). Gene targeting of the catalytic subunit ( Slc7a9) in mice leads to excessive excretion of cystine, lysine, arginine, and ornithine. Here, we studied this non-type I cystinuria mouse model using gene expression ana...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Physiology in Health, Disease and Ageing" ]
10.1038/srep19676
Magnetism and exchange interaction of small rare-earth clusters; Tb as a representative
Here we follow, both experimentally and theoretically, the development of magnetism in Tb clusters from the atomic limit, adding one atom at a time. The exchange interaction is, surprisingly, observed to drastically increase compared to that of bulk, and to exhibit irregular oscillations as a function of the interatomi...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
2725253
Human uterus cell atlas
The Human Uterus Cell Atlas (HUTER) project aims to create the single-cell and spatial reference map of the human uterus. HUTER project will provide unprecedented insight at transcriptomic, genomic and spatial changes of this important female organ not only throughout the menstrual cycle but also across lifespan. The...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing" ]
W44444153
Application of MoS2 based cutting fluids in minimum quantity lubrication during machining of stainless steel AISI 316
Last decade witnessed rapid increase in development of advanced materials for high performance applications. While these materials solve a great deal of technological issue, they also pose considerable challenge in machining due to poor machinability characteristics. Many strategies have been devised. However, environm...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1016/j.bbabio.2017.11.001
Identification of protein W, the elusive sixth subunit of the Rhodopseudomonas palustris reaction center-light harvesting 1 core complex
The X-ray crystal structure of the Rhodopseudomonas (Rps. ) palustris reaction center-light harvesting 1 (RC-LH1) core complex revealed the presence of a sixth protein component, variably referred to in the literature as helix W, subunit W or protein W. The position of this protein prevents closure of the LH1 ring, po...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1038/s41467-018-03677-z
Structural rearrangements of the histone octamer translocate DNA
Nucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic genomes. Nucleosomes are highly dynamic and are remodeled with the help of ATP-dependent remodeling factors. Yet, the mechanism of DNA translocation around the histone octamer is poorly understood. In this study, we present several ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1007/s00216-016-9431-1
Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach
We developed a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the site-specific quantification of lysine acetylation in the N-terminal region of histone H4 by combining chemical derivatization at the protein and peptide levels with digestion using chymotrypsin and trypsin. Unmodified ε-am...
[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
171419
Infrared structural monitoring of cracks using thermoelastic analysis in production environments
This proposal is built around a well-established set of laboratory-based techniques, which use Thermoelastic Stress Analysis (TSA) for characterising strain fields associated with structural features. It is proposed to extend their applicability to aircraft structure tests and to enhance their productivity through the...
[ "Products and Processes Engineering", "Materials Engineering" ]
230290
Social capital and enforcement of informal contracts in developing economies
In the absence of formal contracts and sanctioning agencies, many economic exchanges are based on informal arrangements that cannot be enforced through courts or monitored by external parties. In this project, we study the role of social capital in generating social sanctions that agents can use to enforce informal arr...
[ "The Social World and Its Interactions", "Individuals, Markets and Organisations" ]
3739108
Unlocking self-patterning competence to engineer 3d human spinal cord
Organizers direct formation of the body, releasing morphogens to position tissues and organs. But what organizes the organizers? I aim to harness organizer formation to build self-patterning 3D human spinal cord in vitro. In developing spinal cord, the floorplate organizer secretes Sonic Hedgehog to direct ventral-dor...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Biotechnology and Biosystems Engineering" ]
10.1016/j.concog.2009.12.018
Optimizing subjective measures of consciousness
Dienes and Seth (2010) conclude that confidence ratings and post-decision wagering are two comparable and recommendable measures of conscious experience. In a recently submitted paper, we have however found that both methods are problematic and seem less suited to measure consciousness than a direct introspective measu...
[ "The Human Mind and Its Complexity" ]
10.1016/j.cell.2007.11.034
RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA
MicroRNAs (miRNAs) are inhibitors of gene expression capable of controlling processes in normal development and cancer. In mammals, miRNAs use a seed sequence of 6-8 nucleotides (nt) to associate with 3′ untranslated regions (3′UTRs) of mRNAs and inhibit their expression. Intriguingly, occasionally not only the miRNA-t...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Cell Biology, Development, Stem Cells and Regeneration" ]
W2026728239
The effects of commitment and identification on consumption
Previous work has demonstrated relationships among consumers' perceptions of a service organization's characteristics, their affiliation history with the organization, their consumption of the organization's products and services, and their identification with the organization. Other work has examined similar sets of v...
[ "Individuals, Markets and Organisations", "The Social World and Its Interactions" ]
10.1016/j.geomphys.2015.04.006
On the number of connected components of random algebraic hypersurfaces
We study the expectation of the number of components b<inf>0</inf>(X) of a random algebraic hypersurface X defined by the zero set in projective space RPn of a random homogeneous polynomial f of degree d. Specifically, we consider invariant ensembles, that is Gaussian ensembles of polynomials that are invariant under ...
[ "Mathematics" ]
W2058209443
Statistics and analysis of service availability in cloud computing
This paper focuses on solving the problem of measuring and monitoring service availability in Cloud Computing. It introduces existing Service-Level Agreement (SLA) monitoring approaches and frameworks. On this basis, it presents a new approach which monitors cloud service availability from the client-centric point of v...
[ "Computer Science and Informatics", "Systems and Communication Engineering", "Mathematics" ]
10.1016/j.cub.2016.12.052
A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition
The ability to plan and execute appropriately timed responses to external stimuli is based on a well-orchestrated balance between movement initiation and inhibition. In impulse control disorders involving the prefrontal cortex (PFC) [1], this balance is disturbed, emphasizing the critical role that PFC plays in appropr...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
Q2715853
Sovvenzione di capitale circolante per SERVICE Iwona Zdańska — 15418
Il progetto è volto a sostenere l'impresa nel fornire liquidità e nel sostenere le sue operazioni quotidiane a causa delle difficoltà finanziarie che si sono verificate nella società a causa dell'epidemia di COVID-19. Assistenza finanziaria fornita sulla base del regime SA.57015.
[ "Individuals, Markets and Organisations" ]
10.1038/ncomms12101
Frizzled 7 and PIP 2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
PDZ domain-containing proteins work as intracellular scaffolds to control spatio-temporal aspects of cell signalling. This function is supported by the ability of their PDZ domains to bind other proteins such as receptors, but also phosphoinositide lipids important for membrane trafficking. Here we report a crystal str...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1051/0004-6361/201832718
Sensitivity Of Gravito Inertial Modes To Differential Rotation In Intermediate Mass Main Sequence Stars
Context. While rotation has a major impact on stellar structure and evolution, its effects are not well understood. Thanks to high-quality and long-time base photometric observations obtained with recent space missions, we are now able to study stellar rotation more precisely. Aims. We aim to constrain radial different...
[ "Universe Sciences" ]
802701
Engineering and exploring anyonic quantum gases
This project enters the experimental investigation of anyonic quantum gases. We will study anyons – conjectured particles with a statistical exchange phase anywhere between 0 and π – in different many-body systems. This progress will be enabled by a unique approach of bringing together artificial gauge fields and quant...
[ "Condensed Matter Physics", "Fundamental Constituents of Matter" ]
2731322
Solar twinning to create solar research twins
Research and Innovation (R&I) in Concentrating Solar Thermal (CST) technologies promises global impacts through new and sustainable solutions to societal challenges. CST technologies include 1) Solar Thermal Electricity (STE/CSP), 2) Solar Heat for Industrial Processes (SHIP), 3) Solar Fuels, and 4) Clean and Fresh Wat...
[ "Products and Processes Engineering", "Materials Engineering" ]
US US2005028716
PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS
The invention provides compositions and methods for treating neurodegenerative disorders. The method of the invention involves administering to an individual in need of treatment a composition an acetylcholine esterase inhibitor in combination with another therapeutic agent. The methods and compositions of the inventio...
[ "Neuroscience and Disorders of the Nervous System", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1038/srep42563
Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells
We have used a computational approach to identify anti-fibrotic therapies by querying a transcriptome. A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against a transcriptomic database that quantifies changes in gene expression in response ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Prevention, Diagnosis and Treatment of Human Diseases", "Physiology in Health, Disease and Ageing" ]
10.1007/jhep03(2019)060
Resummation for rapidity distributions in top-quark pair production
Abstract We extend our framework for the simultaneous resummation of soft and small-mass logarithms to rapidity distributions in top quark pair production. We give numerical results for the rapidity distribution of the top quark or the anti-top quark, as well as the rapidity distribution of the $$ t\overline{t} $$ ...
[ "Fundamental Constituents of Matter" ]
10.1073/pnas.1304168111
Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates
Emerging data suggest that in polarized epithelial cells newly synthesized apical and basolateral plasma membrane proteins traffic through different endosomal compartments en route to the respective cell surface. However, direct evidence for trans-endosomal pathways of plasma membrane proteins is still missing and the ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1073/pnas.1811874115
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex
Autophagy is an enigmatic cellular process in which double-membrane compartments, called “autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and package cytoplasmic contents for delivery to lysosomes. Expansion of the precursor membrane phagophore requires autophagy-related 2 (ATG2), which localize...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
851255
Air Transport as Information and Computation
Air transport has by and large been studied as a transportation process, in which different elements, e.g. aircraft or passengers, move within the system. While intuitive, this approach entails several drawbacks, including the need for large-scale simulations, the reliance on real data, and the difficulty of extracting...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1177/0271678X16675182
Nogo A Regulates Vascular Network Architecture In The Postnatal Brain
Recently, we discovered a new role for the well-known axonal growth inhibitory molecule Nogo-A as a negative regulator of angiogenesis in the developing central nervous system. However, how Nogo-A affected the three-dimensional (3D) central nervous system (CNS) vascular network architecture remained unknown. Here, usin...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2897189032
Charge compensation and capacity fading in LiCoO <sub>2</sub> at high voltage investigated by soft x-ray absorption spectroscopy
In order to obtain an in-depth insight into the mechanism of charge compensation and capacity fading in LiCoO2, the evolution of electronic structure of LiCoO2 at different cutoff voltages and after different cycles are studied by soft x-ray absorption spectroscopy in total electron (TEY) and fluorescence (TFY) detecti...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
171844
Flare likelihood and region eruption forecasting
Space weather can have detrimental, and in some cases catastrophic, effects upon a multitude of technologies on which we depend as part our daily lives. Adverse space weather is now known to result from solar flares and coronal mass ejections released from the turbulent and highly complex magnetic fields of active regi...
[ "Universe Sciences", "Computer Science and Informatics" ]
10.1016/j.tet.2014.05.027
The influence of vicinal threo-difluorination on electro-optic and mesogenic properties of propyleneoxy-linked nematic liquid crystals
A protocol for the preparation of a series of liquid crystals is presented, where the structures carry a central propyleneoxy motif carrying two vicinal threo-C-F bonds. The negative dielectric anisotropy (-Δε) of the resultant liquid crystals has been explored. The stereoelectronic relationship between the vicinal C-F...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
638899
Researchers in the knowledge triangle
Since 2006, members of EURAXESS Bulgaria have organized 13 European Researchers Nights (ERN), and have attracted several new consortium members with different profiles - universities, research institutes, NGOs, entrepreneurs. Based on past experience, the main goal of Researchers in the Knowledge Triangle (K-TRIO 5) pr...
[ "The Social World and Its Interactions", "Individuals, Markets and Organisations" ]
10.1177/1354066117745365
International Misrecognition The Politics Of Humour And National Identity In Israel S Public Diplomacy
Recognition, or the lack of it, is a central concern in International Relations. However, how states cope with international misrecognition has so far not been thoroughly explored in International . . .
[ "The Social World and Its Interactions", "Institutions, Governance and Legal Systems" ]
10.1016/j.tree.2013.01.019
Pollinator-mediated evolution of floral signals
Because most plants rely on animals for pollination, insights from animal sensory ecology and behavior are essential for understanding the evolution of flowers. In this review, we compare and contrast three main types of pollinator responses to floral signals - receiver bias, 'adaptive' innate preferences, and associat...
[ "Environmental Biology, Ecology and Evolution", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
219153
Monitoring built-up area from satellite
Survey Lab is a spin off company of Sapienza University devoted to scientific and technological knowledge-transfer in order to capture additional business opportunities in the field of civil and environmental engineering. The company core business is the development and commercialization of innovative geomatic monitori...
[ "Earth System Science", "Products and Processes Engineering", "Computer Science and Informatics" ]
10.1038/s41578-018-0036-5
Heusler, Weyl and Berry
Heusler compounds, initially discovered by Fritz Heusler more than a century ago, have grown into a family of more than 1,000 compounds, synthesized from combinations of more than 40 elements. Recently, by incorporating heavy elements that can give rise to strong spin–orbit coupling, non-trivial topological phases of m...
[ "Condensed Matter Physics", "Synthetic Chemistry and Materials" ]
10.1007/s10955-018-1992-2
Convergence and Efficiency of Adaptive Importance Sampling Techniques with Partial Biasing
We propose a new Monte Carlo method to efficiently sample a multimodal distribution (known up to a normalization constant). We consider a generalization of the discrete-time Self Healing Umbrella Sampling method, which can also be seen as a generalization of well-tempered metadynamics. The dynamics is based on an adapt...
[ "Mathematics", "Computer Science and Informatics", "Physical and Analytical Chemical Sciences" ]
NO 8800014 W
DEVICE IN A BUILDING STRUCTURE
The present invention relates to a device in connection with building structures, especially for supporting structures which by their net weight or by varying loads are subjected to deformation. Especially in connection with large roof structures one is enfaced with the problem that deformations due to net weight or va...
[ "Products and Processes Engineering", "Materials Engineering" ]
338957
Nonequilibrium phenomena at femtosecond/nanometer scale
Nanoscale objects like magnetic molecules and clusters, quantum dots, and graphene, bring us novel physical concepts. Recently, the temporal scale of the order of tens of femtoseconds (femtoscale) became available and new physical phenomena associated with this time scale, such as laser-induced electron and magnetic ph...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
10.1002/mrm.24771
Quantification and correction of respiration induced dynamic field map changes in fMRI using 3D single shot techniques
Purpose Respiration induced dynamic field map changes in the brain are quantified and the influence on the magnitude signal (physiological noise) is investigated. Dynamic off-resonance correction allows to reduce the signal fluctuations overlaying the blood oxygenation level dependent signal in T2*-weighted functional ...
[ "Neuroscience and Disorders of the Nervous System", "Systems and Communication Engineering", "Physical and Analytical Chemical Sciences" ]
W4226303153
Serologic study of Bartonella sp. infection among human population of Southern Spain
The purpose of this study was to determine the prevalence of IgG antibodies against Bartonella sp. in a randomly selected sample from the population of the patients of North Sanitary District of Jaén.We used a commercially available immunofluorescent test (Focus-Technology IFA Bartonella quintana and B. henselae test)....
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases" ]
677952
The Tibetan Army of the Dalai Lamas (1642-1959)
TibArmy proposes to undertake a study of a previously unresearched subject: the Tibetan army during the period of the Buddhist government of the Dalai Lamas, known as the Ganden Phodrang, from 1642 to 1959. This government was the heir to a robust military culture with long experience in the defence of Buddhism since t...
[ "The Study of the Human Past", "Studies of Cultures and Arts" ]
10.1073/pnas.1110682108
Phytochrome-Interacting Factor 4 (PIF4) regulates auxin biosynthesis at high temperature
At high ambient temperature, plants display dramatic stem elongation in an adaptive response to heat. This response is mediated by elevated levels of the phytohormone auxin and requires auxin biosynthesis, signaling, and transport pathways. The mechanisms by which higher temperature results in greater auxin accumulatio...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Environmental Biology, Ecology and Evolution" ]
10.1016/j.jneumeth.2014.02.010
AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations
As part of a project to express chondroitinase ABC (ChABC) in neurons of the central nervous system, we have inserted a modified ChABC gene into an adeno-associated viral (AAV) vector and injected it into the vibrissal motor cortex in adult rats to determine the extent and distribution of expression of the enzyme. A si...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2007320289
Intracranial atherosclerotic disease associated with moyamoya collateral formation: histopathological findings
Atherosclerotic disease has been suspected as a cause of moyamoya disease in some patients but has not, to the authors' knowledge, been confirmed by pathological studies. The authors present the histopathological findings in a patient with moyamoya collateral formation associated with atherosclerotic occlusive disease ...
[ "Physiology in Health, Disease and Ageing", "Neuroscience and Disorders of the Nervous System" ]
10.1016/j.jhevol.2013.09.010
Nutritional values of tortoises relative to ungulates from the Middle Stone Age levels at Blombos Cave, South Africa: Implications for foraging and social behaviour
The site of Blombos Cave (BBC), Western Cape, South Africa has been a strong contributor to establishing the antiquity of important aspects of modern human behaviour, such as early symbolism and technological complexity. However, many linkages between Middle Stone Age (MSA) behaviour and the subsistence record remain t...
[ "The Study of the Human Past", "Environmental Biology, Ecology and Evolution" ]
680156
The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases
Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still uncle...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
W744683817
Spatially resolved X-ray micro/nano-spectroscopy and imaging on the model organism Daphnia magna using laboratory and synchrotron sources
This work demonstrates and further develops spatially resolved laboratory and synchrotron X-ray spectroscopic and imaging experiments to answer specific ecotoxicological questions on the model organism Daphnia magna. The first phase of this work consisted of developing appropriate sample preparation procedures for this...
[ "Physical and Analytical Chemical Sciences", "Environmental Biology, Ecology and Evolution" ]
284340
Sailing into Modernity: Comparative Perspectives on the Sixteenth and Seventeenth Century European Economic Transition
This research project analyses the economic transition in Early Modern Europe through an innovative and interdisciplinary approach that will employ tools from legal, economic and social history for the comparative analysis of the legal position and the economic treatment of sailors active in the Mediterranean. Since Fe...
[ "The Study of the Human Past", "Individuals, Markets and Organisations" ]
864483
Novel Oxides and Topological Interfaces for quantum Computing Electronics
Today’s quantum computers are suffering from a very high error rate due to decoherence (i.e. loss of quantum information) in their qubits fabricated with superconductors junctions or semiconductors quantum dots. The goal of this proposal is to research radically new materials and architectures to build a “fault-toleran...
[ "Condensed Matter Physics", "Synthetic Chemistry and Materials", "Computer Science and Informatics", "Materials Engineering" ]
W2338352461
Electricity in Europe: exiting fossil fuels?
There are many options for generating electricity with low carbon emissions, and the elec- trification of heat and transport can decarbonize energy use across the economy. This places the power sector at the forefront of any move away from fossil fuels, even though fossil-fuelled generators are more dependable and flex...
[ "Products and Processes Engineering", "Systems and Communication Engineering" ]
10.1007/978-3-030-31784-3_22
Efficient Trace Encodings Of Bounded Synthesis For Asynchronous Distributed Systems
The manual implementation of distributed systems is an error-prone task because of the asynchronous interplay of components and the environment. Bounded synthesis automatically generates an implementation for the specification of the distributed system if one exists. So far, bounded synthesis for distributed systems do...
[ "Computer Science and Informatics", "Systems and Communication Engineering" ]
W2036483312
Ultrasonically improved galvanochemical technology for the remediation of industrial wastewater
Two general methodologies adopted for the decontamination of industrial wastewater containing oil and metal ions are flocculation and coagulation. Both methods require the addition of chemicals and in the case of electrocoagulation the additional use of electrical power. Another methodology that was developed in Russia...
[ "Products and Processes Engineering", "Environmental Biology, Ecology and Evolution" ]
10.3390/biology6010005
A molecular view of kinetochore assembly and function
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters. Kinetochores also control feedback mechanisms responsible for the correction of incorrect microtubule attachments, and ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2603535217
Følner functions and the generic Word Problem for finitely generated amenable groups
We introduce and investigate different definitions of effective amenability, in terms of computability of F{\o}lner sets, Reiter functions, and F{\o}lner functions. As a consequence, we prove that recursively presented amenable groups have subrecursive F{\o}lner function, answering a question of Gromov, for the same cl...
[ "Mathematics", "Computer Science and Informatics" ]
W1588650177
Spatial Downscaling of TRMM Precipitation Product Using a Combined Multifractal and Regression Approach: Demonstration for South China
Abstract: The lack of high spatial resolution precipitation data, which are crucial for the modeling and managing of hydrological systems, has triggered many attempts at spatial downscaling. The essence of downscaling lies in extracting extra information from a dataset through some scale-invariant characteristics relat...
[ "Mathematics", "Earth System Science" ]
10.1007/s13171-018-0124-z
Moderate Deviations for Ewens-Pitman Sampling Models
Consider a population of individuals belonging to an infinity number of types, and assume that type proportions follow the Poisson-Dirichlet distribution with parameter α ∈ [0,1) and 𝜃 > −α. Given a sample of size n from the population, two important statistics are the number Kn of different types in the sample, and t...
[ "Mathematics" ]
10.1039/c8ee00875b
Topological and network analysis of lithium ion battery components: the importance of pore space connectivity for cell operation
Pore space connectivity is a useful metric for describing microstructure of lithium ion battery components.
[ "Condensed Matter Physics", "Materials Engineering" ]
10.1093/hmg/ddy425
A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease
The role of somatic variants in diseases beyond cancer is increasingly being recognized, with potential roles in autoinflammatory and autoimmune diseases. However, as mutation rates and allele fractions are lower, studies in these diseases are substantially less tolerant of false positives, and bio-informatics algorith...
[ "Immunity, Infection and Immunotherapy", "Integrative Biology: from Genes and Genomes to Systems", "Computer Science and Informatics" ]
10.1037/a0013738
Additive and Interactive Effects of Stimulus Degradation: No Challenge for CDP+
S. O'Malley and D. Besner (2008) showed that additive effects of stimulus degradation and word frequency in reading aloud occur in the presence of nonwords but not in pure word lists. They argued that this dissociation presents a major challenge to interactive computational models of reading aloud and claimed that no...
[ "The Human Mind and Its Complexity", "Computer Science and Informatics" ]
DE 102007010531 A
Integriertes Digitalradio-Modul
Die Erfindung betrifft ein Audio-Unterhaltungssystem, welches eine Primärschaltkreis-Platine mit einem Prozessor aufweist, der mit einem Antenneneingang, einem Audio-Ausgang und einem Verbinder-Bauteil in Verbindung steht. Der Prozessor ist so konfiguriert, dass er gegebenenfalls das Vorhandensein einer digitalen Audio...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]