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10.1093/cercor/bhw266
Distinct Spatiotemporal Response Properties of Excitatory Versus Inhibitory Neurons in the Mouse Auditory Cortex
In the auditory system, early neural stations such as brain stem are characterized by strict tonotopy, which is used to deconstruct sounds to their basic frequencies. But higher along the auditory hierarchy, as early as primary auditory cortex (A1), tonotopy starts breaking down at local circuits. Here, we studied the ...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
interreg_1508
Green Energy for Green Companies
Project in brief _x000D_ _x000D_ The problem of massive emissions of carbon dioxide (CO2) from the burning of fossil fuels and related climatic impact have become major environmental, scientific and institutional issues worldwide. Long-term sustainability of the atmosphere requires a drastic decrease in CO2 emissions a...
[ "Earth System Science", "Products and Processes Engineering" ]
10.1038/s41598-019-48275-1
The effects of Botulinum toxin on the detection of gradual changes in facial emotion
When we feel sad or depressed, our face invariably “drops”. Conversely, when we try to cheer someone up, we might tell them “keep your smile up”, so presupposing that modifying the configuration of their facial muscles will enhance their mood. A crucial assumption that underpins this hypothesis is that mental states ar...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1126/science.aau3873
Ultrafast disordering of vanadium dimers in photoexcited VO2
Many ultrafast solid phase transitions are treated as chemical reactions that transform the structures between two different unit cells along a reaction coordinate, but this neglects the role of disorder. Although ultrafast diffraction provides insights into atomic dynamics during such transformations, diffraction alon...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
260801
Building an Integrated Genetic Infectious Disease Epidemiology Approach
Epidemiology and public health planning will increasingly rely on the analysis of genetic sequence data. The recent swine-derived influenza A/H1N1 pandemic may represent a tipping point in this trend, as it is arguably the first time when multiple strains of a human pathogen have been sequenced essentially in real time...
[ "Integrative Biology: from Genes and Genomes to Systems", "Prevention, Diagnosis and Treatment of Human Diseases", "Immunity, Infection and Immunotherapy", "Mathematics", "Computer Science and Informatics" ]
W4289443609
Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout
Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated.To investigate whether there is a transient increase in risk of cardiovascular events after a recent gout flare.A retrospective observational study was conducted using electr...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Physiology in Health, Disease and Ageing" ]
615075
Algorithms and Lower Bounds: A Unified Approach
One of the fundamental goals of theoretical computer science is to understand the possibilities and limits of efficient computation. This quest has two dimensions. The theory of algorithms focuses on finding efficient solutions to problems, while computational complexity theory aims to understand when and why problems ...
[ "Computer Science and Informatics" ]
10.1088/1742-6596/1522/1/012020
Coherent Structures In Turbulent Boundary Layers Over An Airfoil
This preliminary study is concerned with the identification of three-dimensional coherent structures, defined as intense Reynolds-stress events, in the turbulent boundary layer developing over the . . .
[ "Condensed Matter Physics", "Products and Processes Engineering" ]
W2030736011
Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults accounting for 31% of all NHL in Western Countries. Following, morphological, biological and clinical studies have allowed the subdivision of DLBCLs into morphological variants, molecular and immunophenotypic subgroups and distinct d...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Immunity, Infection and Immunotherapy" ]
10.1186/1759-8753-4-15
Regulation Of Dna Transposition By Cpg Methylation And Chromatin Structure In Human Cells
Background: The activity of transposable elements can be regulated by different means. DNA CpG methylation is known to decrease or inhibit transpositional activity of diverse transposons. However, very surprisingly, it was previously shown that CpG methylation of the Sleeping Beauty (SB) transposon significantly enhanc...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
W1578044134
Biological, Chemical, and Omics Research ofTaxusMedicinal Resources
Taxus is a botanical source for the anticancer drug taxol (paclitaxel), first reported in 1971 as a result of bioassay guided fractionation of active extracts from stem bark samples of T. brevifolia. This led to additional discoveries of pharmacologically active taxoids in other Taxus species and to investigations on t...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Biotechnology and Biosystems Engineering" ]
10.1007/s00332-012-9148-z
A new minimum principle for Lagrangian mechanics
We present a novel variational view at Lagrangian mechanics based on the minimization of weighted inertia-energy functionals on trajectories. In particular, we introduce a family of parameter-dependent global-in-time minimization problems whose respective minimizers converge to solutions of the system of Lagrange's equ...
[ "Mathematics" ]
10.1038/s41467-017-01571-8
Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ-IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in high-throughput tra...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1161/CIRCULATIONAHA.116.023686
Long Noncoding Rnas In Cardiovascular Pathology Diagnosis And Therapy
Vast parts of mammalian genomes encode for transcripts that are not further translated into proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained paradoxical for a long time. However, a growing body of evidence demonstrates that long noncoding RNAs are dynamically expressed in differ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1016/j.molimm.2019.04.020
Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme
Therapeutic intravenous immunoglobulin preparations (IVIg)are used for treatment of wide range of autoimmune and inflammatory diseases. Versatile mechanisms have been reported to contribute to the immunomodulatory effects of IVIg. Here we demonstrate that IVIg has a strong potential to inhibit pro-inflammatory effect o...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases" ]
Q4428745
Reconstruction of the utility building to increase the educational offer of the Foundation for Empathic Education Development FREE
The planned project aims to expand the educational offer of the FREE Foundation, thanks to the investment in the renovation of the building lent by the Opole City Hall in the wine district in Opole (ul. School 14). Thanks to the new place of activity, the Foundation will be able to increase its educational offer by new...
[ "Products and Processes Engineering", "The Social World and Its Interactions" ]
10.1021/acsami.8b03873
Atomistic Simulations of Geopolymer Models: The Impact of Disorder on Structure and Mechanics
Geopolymers are hydrated aluminosilicates with excellent binding properties. Geopolymers appeal to the construction sector as a more sustainable alternative to traditional cements, but their exploitation is limited by a poor understanding of the linkage between chemical composition and macroscopic properties. Molecular...
[ "Materials Engineering", "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1111/nph.14781
Dose-dependent interactions between two loci trigger altered shoot growth in BG-5 × Krotzenburg-0 (Kro-0) hybrids of Arabidopsis thaliana
Hybrids occasionally exhibit genetic interactions resulting in reduced fitness in comparison to their parents. Studies of Arabidopsis thaliana have highlighted the role of immune conflicts, but less is known about the role of other factors in hybrid incompatibility in plants. Here, we present a new hybrid incompatibili...
[ "Integrative Biology: from Genes and Genomes to Systems", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1002/mana.201400137
The Foldy-Lax approximation of the scattered waves by many small bodies for the Lamé system
We are concerned with the linearized, isotropic and homogeneous elastic scattering problem by many small rigid obstacles of arbitrary, Lipschitz regular, shapes in 3D case. We prove that there exist two constants a0 and c0, depending only on the Lipschitz character of the obstacles, such that under the conditions a≤a0 ...
[ "Mathematics", "Condensed Matter Physics" ]
10.1007/978-981-10-9023-3_4
First Steps Towards An Implantable Electromyography Emg Sensor Powered And Controlled By Galvanic Coupling
In the past it has been proposed to use implanted electromyography (EMG) sensors for myoelectric control. In contrast to surface systems, these implanted sensors provide signals with low cross-talk. To achieve this, miniature implantable devices that acquire and transmit real-time EMG signals are necessary. We have rec...
[ "Systems and Communication Engineering", "Prevention, Diagnosis and Treatment of Human Diseases", "Materials Engineering" ]
10.1126/science.1240537
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Cyclophosphamide is one of several clinically important cancer drugs whose therapeutic efficacy is due in part to their ability to stimulate antitumor immune responses. Studying mouse models, we demonstrate that cyclophosphamide alters the composition of microbiota in the small intestine and induces the translocation o...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2892131324
Search for exact local Hamiltonians for general fractional quantum Hall states
We report on our systematic attempts at finding local interactions for which the lowest-Landau-level projected composite-fermion wave functions are the unique zero energy ground states. For this purpose, we study in detail the simplest non-trivial system beyond the Laughlin states, namely bosons at filling $\nu=\frac{2...
[ "Condensed Matter Physics", "Fundamental Constituents of Matter" ]
10.1007/s00401-010-0715-9
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice
Degeneration of motor neurons contributes to senescence-associated loss of muscle function and underlies human neurodegenerative conditions such as amyotrophic lateral sclerosis and spinal muscular atrophy. The identification of genetic factors contributing to motor neuron vulnerability and degenerative phenotypes in v...
[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.3389/fphys.2019.01442
New Drosophila Circadian Clock Mutants Affecting Temperature Compensation Induced by Targeted Mutagenesis of Timeless
Drosophila melanogaster has served as an excellent genetic model to decipher the molecular basis of the circadian clock. Two key proteins, PERIOD (PER) and TIMELESS (TIM), are particularly well explored and a number of various arrhythmic, slow, and fast clock mutants have been identified in classical genetic screens. I...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
W1973952804
Experimental investigation of inorganic nanofiltration membranes prepared by atomic layer deposition and sol-gel methods for saltless water softening
This study explored saltless water softening with inorganic Nanofiltration (NF) membranes prepared by Atomic Layer Deposition (ALD) and a Tetraorthosilicate (TEOS) sol-gel process applied by the slip cast method. The experimental investigations were performed on different material-based inorganic NF membranes, includin...
[ "Materials Engineering", "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences" ]
10.1016/j.neuron.2016.03.010
Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds
Recently it was proposed that the familial Alzheimer's disease (FAD) causing presenilin (PSEN) mutations PSEN1-L435F and PSEN1-C410Y do not support the generation of Aβ-peptides from the amyloid precursor protein (APP). This challenges the amyloid hypothesis and disagrees with previous work showing that PSEN1 FAD causi...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1016/j.atmosenv.2010.12.039
Carbonaceous aerosol at a forested and an urban background sites in Southern Finland
Submicrometer organic carbon (OC) and elemental carbon (EC) concentrations were studied for one year (2007-2008) in Finland at an urban background site (Helsinki) and a forested site (Hyytiälä). Particles were collected on quartz filters that were analyzed by a thermal-optical carbon analyzer in the laboratory. Results...
[ "Earth System Science", "Physical and Analytical Chemical Sciences" ]
171656
Startup europe partnership
Established by the European Commission in January 2014, the Startup Europe Partnership (SEP) is the first pan-European open platform dedicated to supporting the growth and sustainability of European startups able to compete and raise funds at international and global level. SEP is thereby the first Startup Europe Initi...
[ "Individuals, Markets and Organisations", "Institutions, Governance and Legal Systems" ]
W1654847613
Three-Dimensional Positron Annihilation Momentum Measurement Technique Applied To Measure Oxygen-Atom Defects in 6H Silicon Carbide
Abstract : A three-dimensional Positron Annihilation Spectroscopy System (3DPASS) capable to simultaneously measure three-dimensional electron-positron momentum densities measuring photons derived from annihilation events was designed and characterized. 3DPASS simultaneously collects a single data set of correlated ene...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1039/C5CC08890A
Chirality Transfer From Graphene Quantum Dots
Chiral graphene quantum dots were prepared by acidic exfoliation and oxidation of graphite, dialysis, and esterification with enantiomerically pure (R) or (S)-2-phenyl-1-propanol. Circular dichroism studies support the formation of supramolecular aggregates with pyrene molecules, where a transfer of chirality occurs fr...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.3354/cr01345
Influence of climate drivers and the North Atlantic oscillation on beech growth at marginal sites across the mediterranean
European beech Fagus sylvatica L. represents one of the most commercially and ecologically important forest tree species in Europe. The study of climate-growth relationships may provide relevant information to assist projections of future species' distribution as well as forest management strategies. In this study, 9 ...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
10.1111/acv.12235
Lessons from integrating behaviour and resource selection: activity-specific responses of African wild dogs to roads
Understanding how anthropogenic features affect species' abilities to move within landscapes is essential to conservation planning and requires accurate assessment of resource selection for movement by focal species. Yet, the extent to which an individual's behavioural state (e. g. foraging, resting, commuting) influe...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.1098/rspa.2015.0772
A personal perspective on modelling the climate system
Given their increasing relevance for society, I suggest that the climate science community itself does not treat the development of error-free ab initio models of the climate system with sufficient urgency. With increasing levels of difficulty, I discuss a number of proposals for speeding up such development. Firstly, ...
[ "Earth System Science", "Computer Science and Informatics", "Systems and Communication Engineering" ]
172921
Synthesis and photopolymerisation of new fluorinated macromonomers for the obtaining of high performance fluoropolymers
The PhotoFluo project consists in a consortium of three teams (two from Europe and one from Canada) committed to work for developing novel fluoropolymers suitable for optical and electronic devices, membranes for fuel cells and Li batteries, microfluidics, and biomaterials. This ambitious goal will be achieved starting...
[ "Synthetic Chemistry and Materials", "Materials Engineering", "Physical and Analytical Chemical Sciences" ]
10.1111/1469-8676.12422
Waste And The Superfluous An Introduction
The anthropology of waste, drawing on Mary Douglas’s seminal work as well as later studies of landfills, ragpickers, environmental crises and even social exclusion, is a prism through which to view and understand the crises of neoliberal globalisation. This introduction reviews the literature and identifies some themes...
[ "Studies of Cultures and Arts", "The Social World and Its Interactions" ]
10.1016/j.epsl.2013.10.049
Earth's inner core: Innermost inner core or hemispherical variations?
The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core. Using an extensive n...
[ "Earth System Science", "Condensed Matter Physics" ]
10.1016/j.actbio.2018.11.015
Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction
Hyaluronan (HA)-lipid layers on model (mica) surfaces massively reduce friction as the surfaces slide past each other, and have been proposed, together with lubricin, as the boundary layers accounting for the extreme lubrication of articular cartilage. The ability of such HA-lipid complexes to lubricate sliding biologi...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1007/978-3-319-25264-3_5
Stress Testing Strategic Goals With Swot Analysis
Business strategies are intended to guide a company across the mine fields of competitive markets through the fulfilment of strategic objectives. The design of a business strategy generally considers a SWOT operating context consisting of inherent Strengths (S) and Weaknesses (W) of a company, as well as external Oppor...
[ "Individuals, Markets and Organisations" ]
W2341710550
Non-parametric Analysis of Technical Efficiency of Public Sector Banks (PSBs) in India
The aim of the article is to analyze and evaluate technical efficiency scores of public sector banks (PSBs) in India. The study also determines the nature of return to scale (RTS) of individual banks and thereby identifies the leaders and laggards in the PSBs. To measure the extent of overall technical efficiency, pure...
[ "Individuals, Markets and Organisations", "Computer Science and Informatics" ]
10.1364/OE.24.009693
Limitations In Ionization Induced Compression Of Femtosecond Laser Pulses Due To Spatio Temporal Couplings
It was recently proposed that ionization-induced self-compression could be used as an effective method to further compress femtosecond laser pulses propagating freely in a gas jet [He et al. , Phys. Rev. Lett. 113, 263904 2014]. Here, we address the question of the homogeneity of the self-compression process and show e...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
10.1016/j.jmgm.2015.10.007
Vienna Soil-Organic-Matter Modeler - Generating condensed-phase models of humic substances
Humic substances are ubiquitous in the environment and have manifold functions. While their composition is well known, information on the chemical structure and three-dimensional conformation is scarce. Here we describe the Vienna Soil-Organic-Matter Modeler, which is an online tool to generate condensed phase computer...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics", "Computer Science and Informatics", "Earth System Science" ]
10.1145/2837614.2837674
Estimating Types In Binaries Using Predictive Modeling
Reverse engineering is an important tool in mitigating vulnerabilities in binaries. As a lot of software is developed in object-oriented languages, reverse engineering of object-oriented code is of critical importance. One of the major hurdles in reverse engineering binaries compiled from object-oriented code is the us...
[ "Computer Science and Informatics" ]
interreg_2455
MunServNet: Improving Sustainability of Municipal Service Provision in the Field of Water and Waste Water Management
As budget constraints of most municipalities are increasing, municipal service providers in the water and waste sector face pressures to improve efficiency and decrease costs. Additional challenges arise from legal obligations, such as EC directives to meet water quality and environmental standards as well as from risi...
[ "Products and Processes Engineering", "Environmental Biology, Ecology and Evolution" ]
10.1098/rstb.2014.0038
Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size
The alveolar respiratory unit constitutes one of the main targets of inhaled nanoparticles; the effect of engineered nanomaterials (NMs) on human health is largely unknown. Surfactant protein D (SP-D) is synthesized by alveolar type II epithelial cells and released into respiratory secretions; its main function is in i...
[ "Immunity, Infection and Immunotherapy", "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1088/0957-0233/25/6/065501
Robust Excitation Power Spectrum Design For Broadband Impedance Spectroscopy
This paper focuses on the robust design of broadband impedance spectroscopy (IS) experiments. This contribution extends the optimal IS experiment design presented in previous work (Sanchez et al 2012 Meas. Sci. Technol. 23 085702) in order to design a robust broadband excitation which gives relatively good estimation p...
[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
175401
Neocortical circuits underlying visually-guided behaviors in mice.
Many of our most common behaviors, such as reaching out to grasp an object or turning towards something of interest, require that we transform visual information into a representation that guides action. In humans and other mammals, key steps in this transformation take place in the cerebral cortex, by the cooperative ...
[ "Neuroscience and Disorders of the Nervous System", "Integrative Biology: from Genes and Genomes to Systems" ]
W2167163250
Huge Carbon Sequestration Potential in Global Forests
Forests play an important role in mitigating climate change by absorbing carbon from atmosphere. The global forests sequestrated 2.4±0.4 Pg C y-1 from 1990 to 2007, while the quantitative assessment on the carbon sequestration potential (CSP) of global forests has much uncertainty. We collected and compiled a database ...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
10.1109/ICTAI.2014.72
Small Unsatisfiable Subsets In Constraint Satisfaction
The problem of finding small unsatisfiable subsets of a set of constraints is important for various applications in computer science and artificial intelligence. We study the problem of identifying whether a given instance to the constraint satisfaction problem (CSP) has an unsatisfiable subset of size at most k from a...
[ "Computer Science and Informatics" ]
268515
Dynamic, stem cell-mediated self-renewal in the Drosophila intestine
Cells in intestinal epithelia turn over rapidly due to aging, damage, and toxins produced by the enteric microbiota. Gut homeostasis is maintained by intestinal stem cells (ISCs) that divide to renew the intestinal epithelium, but little is known about how ISC division and differentiation are coordinated with the loss ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2137074361
Enabling energy efficient continuous sensing on mobile phones with LittleRock
Although mobile phones are ideal platforms for continuous human centric sensing, the state of the art phone architectures today have not been designed to support continuous sensing applications. Currently, sampling and processing sensor data on the phone requires the main processor and associated components to be conti...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1039/C6CY00433D
Synthesis Of Nano Ssz 13 And Its Application In The Reaction Of Methanol To Olefins
Nanosized SSZ-13 has been obtained from a one-pot synthesis procedure with the addition of CTAB to the synthesis precursor solution. Nano-SSZ-13 zeolite showed high intracrystalline mesoporosity and compared to standard SSZ-13 presented a much longer lifetime and higher conversion capacity for the reaction of methanol ...
[ "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences" ]
W4281870454
Reflexiones sobre la Educación Ambiental con enfoque territorial en el marco del posconflicto colombiano
Desde el año 2016 Colombia camina, a pasos lentos, hacia un nuevo capítulo su historia: el posconflicto. Contexto que exhorta a (re)pensar el papel de los educadores ambientales. En ese orden, este artículo tiene como objetivo conocer el concepto que estudiantes de licenciatura en ciencias naturales y educación ambient...
[ "Human Mobility, Environment, and Space", "Environmental Biology, Ecology and Evolution" ]
W2805735381
Effect of DEE Oxygenate on Diesel in Algal Biodiesel-Diesel Blends on the Combustion Phenomenon of DI Compression Ignition Engines
Biodiesel derived from Stoechospermum marginatum is analysed in a CI engine to understand its feasibility to be used as fuel. In this study, Soxhlet extraction method was applied to extract the bio oil from the brown sea weed (S. Marginatum) with n-hexane as solvent. Considering the low FFA content through titration, b...
[ "Products and Processes Engineering", "Physical and Analytical Chemical Sciences", "Biotechnology and Biosystems Engineering" ]
W2907245254
Health risk prediction models incorporating personality data: Motivation, challenges, and illustration.
The age of big in health has ushered in an era of prediction models promising to forecast individual health events. Although many models focus on enhancing the predictive power of medical risk factors with genomic data, a recent proposal is to augment traditional health predictors with psychosocial data, such as person...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "The Human Mind and Its Complexity" ]
10.1039/c8lc00827b
Personalised organs-on-chips: functional testing for precision medicine
Organs-on-chips are microfluidic systems with controlled, dynamic microenvironments in which cultured cells exhibit functions that emulate organ-level physiology. They can in principle be ‘personalised' to reflect individual physiology, for example by including blood samples, primary human tissue, and cells derived fro...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Prevention, Diagnosis and Treatment of Human Diseases", "Integrative Biology: from Genes and Genomes to Systems", "Products and Processes Engineering" ]
10.1038/onc.2012.621
Dual regulation of Myc by Abl
The tyrosine kinase c-Abl (or Abl) and the prolyl-isomerase Pin1 cooperatively activate the transcription factor p73 by enhancing recruitment of the acetyltransferase p300. As the transcription factor c-Myc (or Myc) is a known target of Pin1 and p300, we hypothesized that it might be regulated in a similar manner. Cons...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Physiology in Health, Disease and Ageing" ]
10.1021/acsphotonics.7b00792
THz Generation and Detection by Fluorenone Based Organic Crystals
Direct study and control of material properties using terahertz (THz) frequency pulses is an emerging subject with strong potential for future applications. One aspect of the development of THz-based techniques is the search for new materials that can efficiently convert higher frequency light into the THz-frequency ra...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
CA 2010000581 W
SEPARATION OF REACTIVE CELLULOSE FROM LIGNOCELLULOSIC BIOMASS WITH HIGH LIGNIN CONTENT
A process for separating the components of lignocellulosic biomass for the purpose of producing a pure reactive cellulose is disclosed. The process has two stages. In the first stage, the lignocellulosic biomass is pretreated with steam, with or without an acid catalyst and then pressed, with or without the presence of...
[ "Products and Processes Engineering", "Biotechnology and Biosystems Engineering", "Materials Engineering" ]
10.1016/j.neuron.2015.05.034
Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders
Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mechanisms through which these factors interact to confer depression risk are poorly understood. One putative biological mechanism implicates variability in the ability of cortisol, released in response to stress, to trigger ...
[ "Neuroscience and Disorders of the Nervous System", "Integrative Biology: from Genes and Genomes to Systems", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
171735
Drivers of pontocaspian biodiversity rise and demise
Since the 1930s, the unique endemic aquatic biota of the Caspian-Black Sea region is facing a biodiversity crisis as it is severely affected by anthropogenic activities such as habitat destruction, invasive species and pollution. Understanding long-term natural biotic and abiotic drivers of lake system change and bioti...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
W2591937436
Partisan politics, welfare states, and environmental policy outputs in the OECD countries, 1975-2005
Building on the burgeoning literature on the association between the welfare state and the environmental state, this study empirically examines how the politics of the former has affected the development of the latter. We suggest that the size of the welfare state shapes the calculus of environmental policy costs by pa...
[ "Institutions, Governance and Legal Systems", "Individuals, Markets and Organisations" ]
10.1103/PhysRevB.87.245401
Transition between direct and indirect band gap in silicon nanocrystals
Using ground-state density functional theory we study the transition from indirect to direct band gap in hydrogen-terminated silicon nanocrystals (NCs) as a function of decreasing diameter. The studied range, from 1. 0 to 4. 6 nm diameter of nanocrystals, with spherical and Wulff-shape NCs, covers the transition from n...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1007/978-3-319-30000-9_42
Accurate Approximate Diagnosability Of Stochastic Systems
Diagnosis of partially observable stochastic systems prone to faults was introduced in the late nineties. Diagnosability, i. e. the existence of a diagnoser, may be specified in different ways: (1) exact diagnosability (called A-diagnosability) requires that almost surely a fault is detected and that no fault is erron...
[ "Mathematics", "Computer Science and Informatics" ]
10.1039/C6CC09169E
A Peptide Functionalized Nanomotor As An Efficient Cell Penetrating Tool
A nanomotor based strategy for fast cellular entry and cargo delivery is presented. The concept focuses on integrating tat peptide, a basic domain of HIV-1 tat protein, with state of the art nanomotors which possess attractive autonomous properties, facilitating cellular penetration and uptake. The rapid cellular inter...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Materials Engineering" ]
10.1051/0004-6361/201730672
Agn Feedback On Molecular Gas Reservoirs In Quasars At Z 2 4
We present new ALMA observations aimed at mapping molecular gas reservoirs through the CO(3−2) transition in three quasars at z ≃ 2. 4, LBQS 0109+0213, 2QZ J002830. 4-281706, and [HB89] 0329-385. Previous [Oiii] λ 5007 observations of these quasars showed evidence for ionised outflows quenching star formation in their ...
[ "Universe Sciences" ]
10.1038/ncomms3794
Room-temperature air-stable spin transport in bathocuproine-based spin valves
Organic semiconductors, characterized by weak spin-scattering mechanisms, are attractive materials for those spintronic applications in which the spin information needs to be retained for long times. Prototypical spin-valve devices employing organic interlayers sandwiched between ferromagnetic materials possess a figur...
[ "Condensed Matter Physics", "Materials Engineering" ]
10.1103/PhysRevB.95.085403
Spin precession in anisotropic media
We generalize the diffusive model for spin injection and detection in nonlocal spin structures to account for spin precession under an applied magnetic field in an anisotropic medium, for which the spin lifetime is not unique and depends on the spin orientation. We demonstrate that the spin precession (Hanle) line shap...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
EP 84116364 A
REMOTE-CONTROLLED DOOR LOCKING SYSTEM FOR AUTOMOTIVE VEHICLE
Bei einer Einrichtung zur berührungslosen fernbedienbaren Türverriegung insbesondere einerZentralverriegelung von Kraftfahrzeugen ist ein durch den Fahrer transportierbarer und betätigbarer, eine elektromagnetische Strahlung aussendender Kleinsender vorgesehen. In dem Kraftfahrzeug ist mindestens ein Empfänger angeordn...
[ "Products and Processes Engineering", "Systems and Communication Engineering" ]
10.1016/j.dcn.2015.01.006
The neuropsychology of infants' pro-social preferences
The current study is the first to investigate neural correlates of infants' detection of pro- and antisocial agents. Differences in ERP component P400 over posterior temporal areas were found during 6-month-olds' observation of helping and hindering agents (Experiment 1), but not during observation of identically movin...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1007/s00220-010-1133-5
An Algebraic Construction of Boundary Quantum Field Theory
We build up local, time translation covariant Boundary Quantum Field Theory nets of von Neumann algebras Av on the Minkowski half-plane M+ starting with a local conformal net of von Neumann algebras on ℝ and an element V of a unitary semigroup ε(A) associated with A. The case V = 1 reduces to the net A+ considered by R...
[ "Fundamental Constituents of Matter", "Mathematics" ]
W1488138377
Improving the Held and Karp Approach with Constraint Programming
AbstractHeld and Karp have proposed, in the early 1970s, a relaxation for the Traveling Salesman Problem (TSP) as well as a branch-and-bound procedure that can solve small to modest-size instances to optimality [4, 5]. It has been shown that the Held-Karp relaxation produces very tight bounds in practice, and this rela...
[ "Computer Science and Informatics" ]
W2562873944
COMPARATIVE STUDY OF DIFFERENT RELIGIONS IN THE TRANSGENIC PRODUCTS TECHNOLOGY
Today, human are able to use genetic engineering to create new organisms, which normally it is very difficult to do. These organisms that named genetically modified organisms (GMO) are very extensive applications in various sciences and technologies including medicine, pharmaceuticals, industry, agriculture… One of the...
[ "Biotechnology and Biosystems Engineering", "The Social World and Its Interactions", "Environmental Biology, Ecology and Evolution", "Institutions, Governance and Legal Systems" ]
10.1039/c8dt01572d
Self-assembly of porphyrin hexamers via bidentate metal–ligand coordination
UV/vis, NMR and SANS (right) demonstrate self-assembly of Zn porphyrin hexamers (green) with bidentate DABCO (orange) into cylindrical rods (left).
[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
174547
The impact of intangible cultural heritage (ich) in formal, non-formal and informal education and its contribution to the key competences for lifelong learning in the eu reference framework
Europe’s Intangible Cultural Heritage – the skills, music, dance, drama, gastronomy, festivals, crafts, etc which have been passed from one generation to the next – is a hugely important economic and social resource. Yet this aspect of cultural heritage is poorly researched. ‘ICH-Bildung’ proposes to redress that balan...
[ "The Social World and Its Interactions", "Studies of Cultures and Arts" ]
10.1038/nature22964
MTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation. Here we show that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. By using integrative metabolomics in a mo...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1063/1.4869113
Phase Separation Dynamics Of Simple Liquids In Non Uniform Electric Fields
Spatially non-uniform electric fields can phase separate initially homogeneous mixtures of liquids. Here, we investigate the dynamics of phase separation using a modified Cahn-Hilliard equation and find three kinetically distinct regimes in the phase diagram: (1) discontinuous and (2) continuous interface formation kin...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1016/j.socscimed.2014.06.044
One World-One Health and neglected zoonotic disease: Elimination, emergence and emergency in Uganda
This paper traces the emergence and tensions of an internationally constructed and framed One World-One Health (OWOH) approach to control and attempt to eliminate African Trypanosomiasis in Uganda. In many respects Trypanosomiasis is a disease that an OWOH approach is perfectly designed to treat, requiring an integrate...
[ "Environmental Biology, Ecology and Evolution", "Institutions, Governance and Legal Systems", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1126/science.aaw4150
Quantum gas microscopy of Rydberg macrodimers
The subnanoscale size of typical diatomic molecules hinders direct optical access to their constituents. Rydberg macrodimers—bound states of two highly excited Rydberg atoms—feature interatomic distances easily exceeding optical wavelengths. We report the direct microscopic observation and detailed characterization of ...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
EP 2013074756 W
METHOD, SYSTEM AND DEVICE FOR SECURELY TRANSFERRING CONTENT BETWEEN DEVICES WITHIN A NETWORK
A method for securely transferring a content CT between devices (10, 20) within a network. Each device (10, 20) comprises a pre-initialized unique secret value S which is different for each device. The method comprises: an activation phase comprising the steps of:generating, by a management center (1), a network key KN...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1007/s11856-017-1491-1
How far can we go with Amitsur’s theorem in differential polynomial rings?
A well-known theorem by S. A. Amitsur shows that the Jacobson radical of the polynomial ring R[x] equals I[x] for some nil ideal I of R. In this paper, however, we show that this is not the case for differential polynomial rings, by proving that there is a ring R which is not nil and a derivation D on R such that th...
[ "Mathematics" ]
10.1039/C5CC07460F
Protein Delivery With Cell Penetrating Poly Disulfide S
The combination of cell-penetrating poly(disulfide)s with biotin–streptavidin biotechnology provides a simple, general, non-toxic method that avoids significant endosomal capture and delivers proteins directly, even to the nucleoli.
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Biotechnology and Biosystems Engineering" ]
W1974562940
A connectivity model for assessment of HIV transmission risk in injection drug users (IDUs)
The purpose of this study was to produce models composed of mapping of connectivity networks of HIV transmission risk in injection drug users (IDUs). This methodology provided a novel approach and diagnostic tool for understanding HIV infection transmission risk and drug use in the typical niche of IDUs, i.e., a "shoot...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases", "The Social World and Its Interactions", "Computer Science and Informatics" ]
311751
Brain reading of contextual feedback and predictions
We are currently witnessing a paradigm shift in our understanding of human brain function, moving towards a clearer description of cortical processing. Sensory systems are no longer considered as 'passively recording' but rather as dynamically anticipating and adapting to the rapidly changing environment. These new ide...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1039/C7TB03170J
Additives Influence The Phase Behavior Of Calcium Carbonate Solution By A Cooperative Ion Association Process
Amorphous calcium carbonate (ACC) has been widely found in biomineralization, both as a transient precursor and a stable phase, but how organisms accurately control its formation and crystallization pathway remains unclear. Here, we aim to illuminate the role of biologically relevant additives on the phase behaviour of...
[ "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
10.1111/geb.12849
Plant species–area relationships are determined by evenness, cover and aggregation in drylands worldwide
Aim: Species–area relationships (also known as “species–area curves” and “species accumulation curves”) represent the relationship between species richness and the area sampled in a given community. These relationships can be used to describe diversity patterns while accounting for the well-known scale-dependence of sp...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.1091/mbc.E15-02-0101
Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission
During anaphase, distinct populations of microtubules (MTs) form by either centrosome-dependent or augmin-dependent nucleation. It remains largely unknown whether these different MT populations contribute distinct functions to cytokinesis. Here we show that augmin-dependent MTs are required for the progression of both ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1242/dev.178962
EvoChromo: towards a synthesis of chromatin biology and evolution
ABSTRACT Over the past few years, interest in chromatin and its evolution has grown. To further advance these interests, we organized a workshop with the support of The Company of Biologists to debate the current state of knowledge regarding the origin and evolution of chromatin. This workshop led to prospective views ...
[ "Environmental Biology, Ecology and Evolution", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
978961
Late medieval visionary women's impact in early modern castilian spiritual tradition
WIMPACT has two main objectives. In the first place, make an exhaustive research gathering the manuscripts and early printed books on/by European Late Medieval Mystic Women (13th-14th cc.) present in Castile in the premodern period (second half 15th c.-early 16th c.) and catalogue them. In the second place, evaluate th...
[ "Texts and Concepts", "The Study of the Human Past", "Studies of Cultures and Arts" ]
Q2689759
Subvention pour le fonds de roulement pour le Kromet Sp. z o.o.
Le projet concerne le soutien de l’entrepreneur à fournir des liquidités financières et à soutenir les activités en cours en raison des difficultés financières rencontrées par l’entrepreneur à la suite de la pandémie de COVID-19. Assistance financière fournie au titre du programme SA.57015 (2020/N)
[ "Individuals, Markets and Organisations" ]
10.1088/0004-637X/780/1/60
Formation Of The Wide Asynchronous Binary Asteroid Population
We propose and analyze a new mechanism for the formation of the wide asynchronous binary population. These binary asteroids have wide semimajor axes relative to most near-Earth and main belt asteroid systems. Confirmed members have rapidly rotating primaries and satellites that are not tidally locked. Previously sugges...
[ "Universe Sciences" ]
Q2870214
GLOBALPLAS – Product Innovation and Diversification to Combat COVID-19
GLOBALPLAS will invest in product innovation to reformulate its business model and produce Personal Protective Equipment internally, considered relevant products in the fight against COVID-19, namely polycarbonate visors, which will increase added value to the global market
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1007/JHEP01(2018)114
The Action Of The Free 4 0 Theory
The (4, 0) theory in six dimensions is an exotic theory of supergravity that has been argued to emerge as the strong coupling limit of theories having N = 8 supergravity as their low energy effective theory in five spacetime dimensions. It has maximal supersymmetry and is superconformal. Very little is known about this...
[ "Fundamental Constituents of Matter", "Mathematics" ]
10.1038/s41535-019-0207-7
Magnetism and anomalous transport in the Weyl semimetal PrAlGe: possible route to axial gauge fields
In magnetic Weyl semimetals, where magnetism breaks time-reversal symmetry, large magnetically sensitive anomalous transport responses are anticipated that could be useful for topological spintronics. The identification of new magnetic Weyl semimetals is therefore in high demand, particularly since in these systems Wey...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1098/rsos.170349
Do pet dogs (Canis familiaris) follow ostensive and non-ostensive human gaze to distant space and to objects?
Dogs are renowned for being skilful at using humangiven communicative cues such as pointing. Results are contradictory, however, when it comes to dogs’ following human gaze, probably due to methodological discrepancies. Here we investigated whether dogs follow human gaze to one of two food locations better than into di...
[ "The Human Mind and Its Complexity", "Environmental Biology, Ecology and Evolution" ]
10.1038/s41467-019-12733-1
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
Abstract Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma initiation and progression. Recent studies using a Tyr-CreER driven mouse model have drawn contradictory conclusions about the potential of melanocyte stem...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W275283871
Prostate cancer risk among users of digoxin and other antiarrhythmic drugs in the Finnish Prostate Cancer Screening Trial
Long-term usage of the antiarrhythmic drug digoxin has been connected to lowered risk of prostate cancer. A recent study has suggested that beta-blockers might also have similar risk-decreasing effects. We evaluated the association between use of digoxin, beta-blocker sotalol, and other antiarrhythmic drugs and prostat...
[ "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases" ]
184800
Demonstrating synergies in combined natural and engineered processes for water treatment systems
The AquaNES project will catalyse innovations in water and wastewater treatment processes and management through improved combinations of natural and engineered components. Among the demonstrated solutions are natural treatment processes such as bank filtration (BF), managed aquifer recharge (MAR) and constructed wetla...
[ "Products and Processes Engineering", "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.1038/s41598-017-04450-w
3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse
Single-molecule localisation microscopy (SMLM) allows the localisation of fluorophores with a precision of 10-30 nm, revealing the cell's nanoscale architecture at the molecular level. Recently, SMLM has been extended to 3D, providing a unique insight into cellular machinery. Although cluster analysis techniques have b...
[ "Physical and Analytical Chemical Sciences", "Cell Biology, Development, Stem Cells and Regeneration", "Computer Science and Informatics" ]
W4294719090
Hygrophorus roseodiscoideus Bon & Chevassut: Epitypification and Updated Biogeography of a Poorly Known But Widespread Thermophilous Species
Hygrophorus roseodiscoideus Bon & Chevassut: épitypification et mise à jour biogéographique d'une espèce thermophile méconnue mais répandue. Hygrophorus roseodiscoideus Bon & Chevassut est une espèce méconnue jusqu'ici supposée restreinte aux chênaies méditerranéennes d'Europe occidentale. À l'heure où les sciences nat...
[ "Environmental Biology, Ecology and Evolution" ]
10.1007/s00205-019-01368-7
Asymptotic Density of Collision Orbits in the Restricted Circular Planar 3 Body Problem
For the Restricted Circular Planar 3 Body Problem, we show that there exists an open set U in phase space of fixed measure, where the set of initial points which lead to collision is O(μ120) dense as μ→ 0.
[ "Mathematics", "Universe Sciences" ]