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242664
Chromatin Mediators of Estrogen Receptor Biology
Estrogen Receptor (ER) drives proliferation in breast cancers and drugs such as tamoxifen and Aromatase Inhibitors, that target ER activity, are first line treatments in clinical practice. However drug resistance is a significant clinical problem. My laboratory has reported that chromatin-modifying pioneer factors are ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems", "Physiology in Health, Disease and Ageing" ]
10.1128/JVI.01751-17
Viperin Targets Flavivirus Virulence By Inducing Assembly Of Noninfectious Capsid Particles
Efficient antiviral immunity requires interference with virus replication at multiple layers targeting diverse steps in the viral life cycle. Here we describe a novel flavivirus inhibition mechanis . . .
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.5194/cp-14-1315-2018
Relative timing of precipitation and ocean circulation changes in the western equatorial Atlantic over the last 45 kyr
Abstract. Thanks to its optimal location on the northern Brazilian margin, core MD09-3257 records both ocean circulation and atmospheric changes. The latter occur locally in the form of increased rainfall on the adjacent continent during the cold intervals recorded in Greenland ice and northern North Atlantic sediment ...
[ "Earth System Science" ]
218520
Durable, environmentally friendly and high-quality leather alternative
Materiko is an Italian company specialising in the manufacture of revolutionary artificial high quality textiles. Due to the flexibility, and high-quality afforded by genuine leather, compared to conventional textiles, it has been used for centuries as material in several industries. However, leather is prone to scratc...
[ "Materials Engineering", "Synthetic Chemistry and Materials", "Products and Processes Engineering" ]
185559
Revolutionizing insect control
EFSA recently prohibited 75% of insecticides to account for their toxicity and ecotoxicity. Moreover, the spread of insecticide resistance and invasion of Europe by new tropical vectors and pests require the development of alternative biological techniques. Recently, we hypothesized that shifting the vision of the ster...
[ "Environmental Biology, Ecology and Evolution", "Biotechnology and Biosystems Engineering", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1063/1.4793200
Different Tips For High Resolution Atomic Force Microscopy And Scanning Tunneling Microscopy Of Single Molecules
We explore different tip functionalizations for atomic force microscopy (AFM), scanning tunneling microscopy (STM), and Kelvin probe force microscopy (KPFM) of organic molecules on thin insulating films. We describe in detail how tips terminated with single Br and Xe atoms can be created. The performance of these tips ...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
268004
Microrobotics and Nanomedicine
The introduction of minimally invasive surgery in the 1980’s created a paradigm shift in surgical procedures. Health care is now in a position to make a more dramatic leap by integrating newly developed wireless microrobotic technologies with nanomedicine to perform precisely targeted, localized endoluminal techniques....
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Products and Processes Engineering", "Materials Engineering" ]
10.1007/s12035-017-0737-6
Cholinergic behavior state-dependent mechanisms of neocortical gain control: A neurocomputational study
The embodied mammalian brain evolved to adapt to an only partially known and knowable world. The adaptive labeling of the world is critically dependent on the neocortex which in turn is modulated by a range of subcortical systems such as the thalamus, ventral striatum, and the amygdala. A particular case in point is th...
[ "Neuroscience and Disorders of the Nervous System", "Computer Science and Informatics" ]
10.3389/fnana.2010.00136
What is the degree of segregation between striatonigral and striatopallidal projections?
In contrast to most other brain regions, in the striatum the output neurons (the medium-sized spiny neurons, MSNs) are GABAergic and act by inhibiting their targets. The standard model of the basal ganglia is built on the segregation of information processing in the direct and indirect pathways, which act in opposing d...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
W2169668129
Reliability Analysis of Bridge under Multi Adverse Factors
A bridge is a structure built to span physical obstacles such as a body of water, valley, or road, for the purpose of providing passage over the obstacle. As critical transportation junction in the transportation network, bridge controls the traffic capacity of the transportation network. In the past decade, collapse o...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1007/978-3-030-24258-9_1
Circular Yet Sound Proofs
We introduce a new way of composing proofs in rule-based proof systems that generalizes tree-like and dag-like proofs. In the new definition, proofs are directed graphs of derived formulas, in which cycles are allowed as long as every formula is derived at least as many times as it is required as a premise. We call suc...
[ "Mathematics", "Computer Science and Informatics" ]
949583
Foundations of Motivic Real K-Theory
Quadratic forms are ubiquitous throughout mathematics, playing a fundamental role in areas from arithmetic through algebra and geometry. In surgery theory, quadratic forms feature prominently in the classification of smooth manifolds in a given homotopy type, while in arithmetic geometry they can be used to encode Galo...
[ "Mathematics" ]
10.1016/j.molcel.2017.02.017
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of physiologically relevant processes is still unclear. Here we perfor...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1103/PhysRevE.96.062304
Scarcity of crossing dependencies: A direct outcome of a specific constraint?
The structure of a sentence can be represented as a network where vertices are words and edges indicate syntactic dependencies. Interestingly, crossing syntactic dependencies have been observed to be infrequent in human languages. This leads to the question of whether the scarcity of crossings in languages arises from ...
[ "Mathematics", "The Human Mind and Its Complexity", "Computer Science and Informatics" ]
W2004554978
A narrowband optical parametric oscillator tunable over 6.8 THz through degeneracy with a transversely-chirped volume Bragg grating
An efficient nanosecond optical parametric oscillator (OPO) with output energies of 0.75 mJ using a periodically poled KTiOPO4 crystal pumped at 532 nm and generating narrowband output continuously tunable over the range of 6.8 THz, between 1053 nm and 1075 nm, is demonstrated by employing a transversely-chirped volume...
[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
10.1038/s41467-019-10068-5
Bacteroidetes use thousands of enzyme combinations to break down glycans
Unlike proteins, glycan chains are not directly encoded by DNA, but by the specificity of the enzymes that assemble them. Theoretical calculations have proposed an astronomical number of possible isomers (> 10 12 hexasaccharides) but the actual diversity of glycan structures in nature is not known. Bacteria of the Bact...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Environmental Biology, Ecology and Evolution" ]
10.1007/s10237-018-1010-2
A hybrid computational model for collective cell durotaxis
Collective cell migration is regulated by a complex set of mechanical interactions and cellular mechanisms. Collective migration emerges from mechanisms occurring at single cell level, involving processes like contraction, polymerization and depolymerization, of cell–cell interactions and of cell–substrate adhesion. He...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Condensed Matter Physics", "Computer Science and Informatics" ]
Q4938541
(16807.19102018.132000767) STUDIO E SVILUPPO DI MODELLI DI GIOIELLI
RAIKA SRL, AZIENDA OPERANTE NEL SETTORE ORAFO VUOLE AUMENTARE LA PROPRIA CAPACIT? DI PENETRAZIONE NEL MERCATO E DI RISPONDERE IN MODO PI? EFFICACE ED EFFICIENTE ALLE ESIGENZE DELLA CLIENTELA.IN PARTICOLARE RAIKA, SRL, VUOLE ACCRESCERE LA PROPRIA OFFERTA ALL?INTERNO DELLA LIBIA, MERCATO CHE NELL?ULTIMO DECENNIO HA RAPPR...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1109/ISIT.2013.6620674
Reconstructing A Graph From Path Traces
This paper considers the problem of inferring the structure of a network from indirect observations. Each observation (a “trace”) is the unordered set of nodes which are activated along a path through the network. Since a trace does not convey information about the order of nodes within the path, there are many feasibl...
[ "Mathematics", "Computer Science and Informatics" ]
W3216652879
Les représentations sociales des fournisseuses de gamètes en Espagne : derrière le « don » d’ovocyte, un travail invisibilisé et dévalorisé ?
Cadre de la recherche : L’Espagne se classe au premier rang en Europe en matière de « don » d’ovules. Leur production et leur commercialisation constituent aujourd’hui l’un des marchés les plus lucratifs du système économique national. Objectifs : Comment les femmes cédant leurs ovules comprennent-elles ce « don » ? Da...
[ "The Social World and Its Interactions", "Individuals, Markets and Organisations" ]
10.1073/pnas.1506214112
Discontinuity of cortical gradients reflects sensory impairment
Topographic maps and their continuity constitute a fundamental principle of brain organization. In the somatosensory system, wholebody sensory impairment may be reflected either in cortical signal reduction or disorganization of the somatotopic map, such as disturbed continuity. Here we investigated the role of continu...
[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing" ]
10.1186/s12936-018-2437-8
Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches
Background: 8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but ch...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1021/acs.jpca.7b01107
Multiphase Photochemistry of Pyruvic Acid under Atmospheric Conditions
Aerosol and molecular processing in the atmosphere occurs in a complex and variable environment consisting of multiple phases and interfacial regions. To explore the effects of such conditions on the reactivity of chemical systems, we employ an environmental simulation chamber to investigate the multiphase photolysis o...
[ "Physical and Analytical Chemical Sciences", "Earth System Science" ]
interreg_3019
Establishment of a platform and a Tunisian-Italian network for surveillance of emerging diseases transmitted by ticks and Culicidae (mosquitoes)
The project aims to strengthen and improve the control of diseases transmitted by zoonotic vectors (MTVZ) emerging due to bacteria transmitted by ticks or fleas, and viruses transmitted by mosquitoes. This monitoring system requires the creation of a cross-border network for the epidemiological surveillance, which, tha...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Environmental Biology, Ecology and Evolution", "Biotechnology and Biosystems Engineering" ]
10.1111/ejn.12645
Stopping movements: When others slow us down
Previous research has shown that performing joint actions can lead to the representation of both one's own and others' actions. In the present study we explored the influence of co-representation on response stopping. Are joint actions more difficult to stop than solo actions? Using a variation of the stop-signal task,...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1039/c9cc03903a
Tailoring patches on particles: a modified microcontact printing routine using polymer-functionalised stamps
We present a microcontact printing (μCP) routine suitable to transfer low molecular weight compounds as ink (LMWI) on silica microparticles.
[ "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
W2385449572
On the Innovation Being the Impetus of Formation and Development of Socialism Theory with Chinese Characteristics
Since the reform and opening up,Our Party develops the Marx doctrine to a new stage in China.The party always adheres to the Marx doctrine the innovation spirit,and achieves the innovation Marx theory on the basis practice.The innovation fruit is the socialism theory with Chinese characteristics.It is composed Deng Xia...
[ "Texts and Concepts", "Institutions, Governance and Legal Systems" ]
W2000596347
Traffic Behaviors Simulation under Congestion Pricing Revenue Redistribution Strategy
On the basis of behavioral model under congestion pricing revenue redistribution, this paper proposes the general idea, process of the simulation and designs the essential simulation module of congestion pricing revenue redistribution based on the Multi-Agent technology and Starlogo. Traffic behaviors are simulated und...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1007/s00723-018-1030-1
Impurities of [1-<sup>13</sup>C]Pyruvic Acid and a Method to Minimize Their Signals for Hyperpolarized Pyruvate Metabolism Studies
Impurities are a necessary evil when working with hyperpolarized [1-13C]pyruvate for real-time metabolic studies. We show that the impurities’ spectrum persists throughout the detection window as these signals show a long T1. At the same time, the impurities’ spectrum is unpredictable and partly susceptible to minute p...
[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W1509147166
Delay-tolerant-networks design and prospect on fishery communication networks
In archipelagic countries, vast maritime monitoring is a though problem. Non proportional comparison of sea patrols number to vast area of the sea is the main reason. This paper will investigate Delay-Tolerant-Networks prospect as communication backbone for fishery based surveillance system. Every fishing ships are cap...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1016/j.aca.2018.04.071
Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands
Target selectivity is one of the main challenges in the search for small molecules able to act as effective and non-toxic anticancer and/or antiviral drugs. To achieve this goal, handy, rapid and reliable High Throughput Screening methodologies are needed. We here describe a novel functionalization for the solid phase ...
[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2046782782
Ferroelectric domain structure of the BiFeO3 film grown on different substrates
Abstract Domain structure of BiFeO 3 (BFO) films grown on different substrates, with a conductive La 0.7 Sr 0.3 MnO 3 underlayer, has been experimentally studied. Two oppositely orientated polarizations, along the long body diagonal to the perovskite unit cell of BFO, are detected in the BFO films on the (0 0 1)-orient...
[ "Condensed Matter Physics", "Synthetic Chemistry and Materials" ]
W2885614850
Chiral Inductions in Excited State Reactions: Photodimerization of Alkyl 2-Naphthoates as a Model
Enantioselectivity in organic transformations continues to be a topic major interest in organic photochemistry. In the last decade, synergistic combination of photocatalysis and organocatalysis has emerged as a powerful strategy to gain enantioselectivity in photochemical reactions, and remarkable achievements have bee...
[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1016/j.foreco.2014.01.028
The fate of populations of Euterpe oleracea harvested for palm heart in Colombia
Palm heart is an important non-timber forest product obtained from various palm species in tropical forests. We studied the effect of four decades of palm heart extraction from the clonal palm Euterpe oleracea at the southern Pacific coast of Colombia. We monitored populations that had been subject to a range of harves...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.1177/0309132516664800
Digital Turn Digital Geographies
Geography is in the midst of a digital turn. This turn is reflected in both geographic scholarship and praxis across sub-disciplines. We advance a threefold categorization of the intensifying relationship between geography and the digital, documenting geographies produced through, produced by, and of the digital. Inste...
[ "Human Mobility, Environment, and Space", "Computer Science and Informatics" ]
758636
Country of Words: Reading and Reception of Palestinian Literature from 1948 to the Present
This project proposes a deep and thorough study of Palestinian literature as an early and on-going case of literary displacement. It aims to find new ways to account for and analyse texts, literary production and reading publics that challenge and lie outside conventional conceptions of the nation-state. The proposed m...
[ "The Study of the Human Past", "Texts and Concepts" ]
AU 2018/202204 A
SOIL TREATMENT COMPOSITION
A synergistic composition, method and kit for controlling, suppressing or preventing plant pathogens in soil is provided. The composition comprises (A) Tagetes (Marigold) essential oil, 5 (B) A/ium sativum (garlic) essential oil, (C) Brassica (mustard) essential oil, and (D) Capsicum (chilli) essential oil, in which th...
[ "Environmental Biology, Ecology and Evolution", "Biotechnology and Biosystems Engineering", "Products and Processes Engineering" ]
Q4773731
SMARTWORKING_2020 - INCENTIVI PER L'ATTUAZIONE DI PIANI AZIENDALI DI SMART WORKING
IN OTTEMPERANZA AL DPCM 8 MARZO 2020 E AL DPCM 11 MARZO 2020, L AZIENDA DOC ARCHIVIAZIONE DOCUMENTALE HA ATTIVATO LA MODALIT DI LAVORO AGILE (SMART WORKING) PER I SUOI DIPENDENTI. L ESERCIZIO DEL PROPRIO LAVORO DA REMOTO E IN MODALIT CONDIVISA FRA I DIVERSI DIPENDENTI RENDE NECESSARIA LA PRESENZA DI STRUMENTI DIGITALI ...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1037/xhp0000174
A familiarity disadvantage for remembering specific images of faces
Familiar faces are remembered better than unfamiliar faces. Furthermore, it is much easier to match images of familiar than unfamiliar faces. These findings could be accounted for by quantitative differences in the ease with which faces are encoded. However, it has been argued that there are also some qualitative diffe...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
865463
Cultural diversity in the Middle Nile Valley. Reconstructing biographies in the periphery of urban centres in northern Sudan during the Bronze Age
One of the biggest scientific challenges for archaeology is to move away from established concepts of cultural categories such as static views of culture, which are not suitable to describe realities of ancient lives. Significant work on the complex encounters between Egyptian and Nubian groups in the Middle Nile was c...
[ "The Study of the Human Past", "Human Mobility, Environment, and Space", "Studies of Cultures and Arts" ]
W2064926487
A Prospective Study of Ideal Cardiovascular Health and Depressive Symptoms
Ideal cardiovascular health is a new construct defined by the American Heart Association as part of its 2020 Impact Goal.The purpose of this study was to examine whether the simultaneous presence of ideal cardiovascular health behaviors and factors could reduce the odds of developing depressive symptoms.Participants fr...
[ "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases", "The Human Mind and Its Complexity" ]
W2002947030
VIOLENCE, BACKPACKERS, SECURITY AND CRITICAL REALISM
Abstract This article provides a critical realist perspective on the juncture between tourism and crime in a city in Far Northern Queensland, Australia. The results of empirical studies into alcohol-related assault and sexual assault are presented and a micro-level study of the responses of the public safety community ...
[ "The Social World and Its Interactions", "Human Mobility, Environment, and Space" ]
US 2014/0025923 W
METHODS OF INCREASING RESISTANCE OF CROP PLANTS TO HEAT STRESS AND SELECTING CROP PLANTS WITH INCREASED RESISTANCE TO HEAT STRESS
Methods of increasing the resistance of a crop plant to heat stress and in particular methods of improving the grain yield and quality of crop plants grown under heat stress in the form of increased minimal temperatares are provided. The methods include selecting plants with increased expression of HYR and growing thes...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Biotechnology and Biosystems Engineering" ]
10.3847/2041-8205/823/2/L40
Constraints On Photoionization Feedback From Number Counts Of Ultra Faint High Redshift Galaxies In The Frontier Fields
We exploit a sample of ultra-faint high-redshift galaxies ( demagnified HST H160 magnitude > 30) in the Frontier Fields clusters A2744 and M0416 to constrain a theoretical model for the UV luminosity function (LF) in the presence of photoionization feedback. The objects have been selected on the basis of accurate photo...
[ "Universe Sciences" ]
Q2688726
Intensification of export activity of the company Spółdzielnia Invalidów “METAL” on foreign markets in order to promote the brand of the Polish Economy.
SA 42799(2015/X) The object of the project is the participation of the Invalidity Cooperative “METAL” in the Programme for the promotion of the machinery and equipment industry. As a result of its participation in the Programme, the company will significantly increase its export activity on selected foreign markets: th...
[ "Products and Processes Engineering", "Individuals, Markets and Organisations" ]
850405
Dissecting the chromatin response to DNA damage in silenced heterochromatin regions
Cells are continuously exposed to insults that can break or chemically modify their DNA. To protect the DNA, cells have acquired an arsenal of repair mechanisms. Proper repair of DNA damage is essential for organismal viability and disease prevention. What is often overlooked is the fact that the eukaryotic nucleus con...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1128/AEM.05531-11
Development Of Phoh As A Novel Signature Gene For Assessing Marine Phage Diversity
Phages play a key role in the marine environment by regulating the transfer of energy between trophic levels and influencing global carbon and nutrient cycles. The diversity of marine phage communities remains difficult to characterize because of the lack of a signature gene common to all phages. Recent studies have de...
[ "Environmental Biology, Ecology and Evolution", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1073/pnas.1607497113
Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax
Incipient sympatric speciation in blind mole rat, Spalax galili, in Israel, caused by sharp ecological divergence of abutting chalk-basalt ecologies, has been proposed previously based on mitochondrial and whole-genome nuclear DNA. Here, we present new evidence, including transcriptome, DNA editing, microRNA, and codon...
[ "Integrative Biology: from Genes and Genomes to Systems", "Environmental Biology, Ecology and Evolution", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1080/17441692.2016.1187191
Relationships Between Poverty And Aids Illness In South Africa An Investigation Of Urban And Rural Households In Kwazulu Natal
ABSTRACTThe association between poverty and HIV/AIDS in Sub-Saharan Africa remains contested. A better understanding of the relationship between the prevalence of poverty and the disease is essential for addressing prevention, treatment, and care. The present study interrogates this relationship, using a cross-sectiona...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "The Social World and Its Interactions" ]
interreg_159
Action to limit the risk of spread of Invasive Introduced species in the Mediterranean
The issue of invasive alien species is emerging and still poorly circumscribed, although it is acknowledged to be the second leading cause of biodiversity loss. These species know no borders, and current ways of life increase the risk of their introduction. Some pose a threat to the economy and health. Their propagatio...
[ "Environmental Biology, Ecology and Evolution", "Human Mobility, Environment, and Space", "Institutions, Governance and Legal Systems" ]
338478
Authoritarianism2.0: The Internet, Political Discussion, and Authoritarian Rule in China
I suggest that perceptions of diversity and disagreement voiced in the on-line political discussion may play a key role in mobilizing citizens to voice their views and take action in authoritarian regimes. The empirical focus is the Chinese Internet. Subjective perceptions of group discussion among participants can si...
[ "The Social World and Its Interactions", "Institutions, Governance and Legal Systems" ]
10.1016/j.cma.2019.06.024
Linear stability analysis of strongly coupled fluid–structure problems with the Arbitrary-Lagrangian–Eulerian method
The stability analysis of elastic structures strongly coupled to incompressible viscous flows is investigated in this paper, based on a linearization of the governing equations formulated with the Arbitrary-Lagrangian–Eulerian method. The exact linearized formulation, previously derived to solve the unsteady non-linear...
[ "Condensed Matter Physics", "Products and Processes Engineering", "Mathematics" ]
10.1109/TSE.2010.98
Automated Abstractions For Contract Validation
Pre/postcondition-based specifications are commonplace in a variety of software engineering activities that range from requirements through to design and implementation. The fragmented nature of these specifications can hinder validation as it is difficult to understand if the specifications for the various operations ...
[ "Computer Science and Informatics" ]
W1974145086
Redox processes in the safety case of deep geological repositories of radioactive wastes. Contribution of the European RECOSY Collaborative Project
Redox processes influence key geochemical characteristics controlling radionuclide behaviour in the near and far field of a nuclear waste repository. A sound understanding of redox related processes is therefore of high importance for developing a Safety Case, the collection of scientific, technical, administrative and...
[ "Earth System Science", "Physical and Analytical Chemical Sciences" ]
10.1016/j.molcel.2018.11.036
Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
Cellular mechanisms that safeguard genome integrity are often subverted in cancer. To identify cancer-related genome caretakers, we employed a convergent multi-screening strategy coupled to quantitative image-based cytometry and ranked candidate genes according to multivariate readouts reflecting viability, proliferati...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1093/ajh/hpx114
Office and Home Blood Pressures as Determinants of Electrocardiographic Left Ventricular Hypertrophy among Black Nigerians Compared with White Flemish
BACKGROUND The association of electrocardiographic left ventricular hypertrophy (ECG-LVH) with blood pressure (BP) in Blacks living in sub-Saharan Africa remains poorly documented. METHODS In 225 Black Nigerians and 729 White Flemish, we analyzed QRS voltages and voltage-duration products and 12 criteria diagnostic of ...
[ "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1063/1.5055622
High Efficiency Shallow Etched Grating On Gaas Membranes For Quantum Photonic Applications
We have designed and fabricated a shallow-etched grating on gallium arsenide nanomembranes for efficient chip-to-fiber coupling in quantum photonic integrated circuits. Experimental results show that the grating provides a fiber-coupling efficiency of >60%, a greatly suppressed back reflection of 43 nm. Highly efficien...
[ "Condensed Matter Physics", "Systems and Communication Engineering", "Synthetic Chemistry and Materials" ]
10.1016/j.dnarep.2009.02.004
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells
Although the basic principle of nucleotide excision repair (NER), which can eliminate various DNA lesions, have been dissected at the genetic, biochemical and cellular levels, the important in vivo regulation of the critical damage recognition step is poorly understood. Here we analyze the in vivo dynamics of the essen...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1111/nph.16039
Massive postglacial gene flow between European white oaks uncovered genes underlying species barriers
Oaks are dominant forest tree species widely distributed across the Northern Hemisphere, where they constitute natural resources of economic, ecological, social and historical value. Hybridisation and adaptive introgression have long been thought to be major drivers of their ecological success. Therefore, the maintenan...
[ "Environmental Biology, Ecology and Evolution", "Integrative Biology: from Genes and Genomes to Systems" ]
DE 19931983 A
Bobbin conveyor with vertical and horizontal runs includes turning section with conveyor stabilizing roller to resist transverse forces
A conveyor (24) has a transverse diverting section (38) in the guide slot (36) for the bobbin carriers (32) so that the bobbins (18,18') are clear of each other as they rotate from the vertical to the horizontal section. To resist the transverse forces (F) a passive stabilizing device, e.g. a roller (56) with a high fr...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1017/CHO9781139017831.010
Becoming Human Archaeology Of The Sub Saharan Middle Stone Age
Introduction The Sub-Saharan Middle Stone Age (MSA) is the place and time where humans evolved into anatomically, genetically and behaviourally modern beings. Whether this was a unique evolutionary trajectory is being debated, but it is now widely accepted as being true for the particular period and region under discus...
[ "The Study of the Human Past", "Environmental Biology, Ecology and Evolution" ]
184390
Contextualising psychosocial wellbeing and mental health within sociocultural dynamics
The lack of contextualization of the science and applications of mental health is the source of a large part of its criticisms. From the lack of research on how social dynamics influence the well-being of citizens, to the gaps in research and coordinated implementation of different disciplines involved in ...
[ "The Social World and Its Interactions", "The Human Mind and Its Complexity" ]
10.1016/j.cell.2013.07.017
XThe yeast ski complex: Crystal structure and rna channeling to the exosome complex
The Ski complex is a conserved multiprotein assembly required for the cytoplasmic functions of the exosome, including RNA turnover, surveillance, and interference. Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry. The crystal structure of an S. cerevisiae 370 kDa core complex shows that Ski3 forms ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1167/iovs.16-20448
Chemogenetic activation of ipRGCs drives changes in dark-adapted (Scotopic) electroretinogram
PURPOSE. The purpose of this study was to investigate the impact of activating melanopsinexpressing intrinsically photosensitive retinal ganglion cells (ipRGCs) on dark-adapted (scotopic) electroretinograms (ERG). METHODS. We used mice (Opn4Cre/+) expressing cre recombinase in melanopsin-expressing cells for a targeted...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.2138/am-2018-6700CCBY
How geometry and anisotropy affect residual strain in host-inclusion systems: Coupling experimental and numerical approaches
Raman spectroscopy provides information on the residual strain state of host-inclusion systems that, coupled with the elastic geobarometry theory, can be used to retrieve the P-T conditions of inclusion entrapment. In situ Raman measurements of zircon and coesite inclusions in garnet from the ultrahigh-pressure Dora Ma...
[ "Earth System Science", "Physical and Analytical Chemical Sciences" ]
724425
BiogENesis and Degradation of Endoplasmic Reticulum proteins
The Endoplasmic Reticulum (ER) membrane in all eukaryotic cells has an intricate protein network that facilitates protein biogene-sis and homeostasis. The molecular complexity and sophisticated regulation of this machinery favours study-ing it in its native microenvironment by novel approaches. Cryo-electron tomography...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1016/j.cell.2017.07.035
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their epidermal and muscle stem cells retain a robustly rhythmic core circadian machinery. However, the oscil...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Physiology in Health, Disease and Ageing" ]
10.1364/OE.23.010444
Numerical Investigation Of The Flat Band Bloch Modes In A 2D Photonic Crystal With Dirac Cones
A numerical method combining complex-k band calculations and absorbing boundary conditions for Bloch waves is presented. We use this method to study photonic crystals with Dirac cones. We demonstrate that the photonic crystal behaves as a zero-index medium when excited at normal incidence, but that the zero-index behav...
[ "Condensed Matter Physics", "Systems and Communication Engineering" ]
10.1051/0004-6361/201629925
Gaia Data Release 1 Testing Parallaxes With Local Cepheids And Rr Lyrae Stars
Parallaxes for 331 classical Cepheids, 31 Type II Cepheids and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). In order to test these first parallax measurements of the primary standard c...
[ "Universe Sciences" ]
10.1016/j.coi.2011.02.001
MicroRNA control of lymphocyte differentiation and function
MicroRNAs (miRNAs) are a class of endogenous, non-coding regulatory RNAs that control gene regulation by guiding silencing protein complexes to mRNA in a sequence-dependent manner. In this way miRNAs are able to repress gene expression post-transcriptionally by affecting mRNA stability or translation. These ubiquitous ...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1109/PN.2016.7537892
Packaged Mzis Passively Balanced By Means Of Multimode Grating Couplers
We present a novel Mach-Zehnder Interferometer configuration that can be passively balanced by adjusting the position of the input fiber over a multimode input coupler, thus correcting phase deviations typically arising from fabrication asymmetries. Characterization after permanent fiber array attachment by means of a ...
[ "Systems and Communication Engineering", "Physical and Analytical Chemical Sciences" ]
10.1038/ncomms5868
Duplication of a promiscuous transcription factor drives the emergence of a new regulatory network
The emergence of new genes throughout evolution requires rewiring and extension of regulatory networks. However, the molecular details of how the transcriptional regulation of new gene copies evolves remain largely unexplored. Here we show how duplication of a transcription factor gene allowed the emergence of two inde...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
225345
Energy neutral wireless sensor networks
Urbanisation is a significant worldwide trend that Smart City technologies aim to address through prolific smart sensing and intelligent actuation and control. However, the high battery replacement costs of wireless sensors impede innovation and long-term deployments. This project aims to alleviate this problem through...
[ "Products and Processes Engineering", "Systems and Communication Engineering", "Computer Science and Informatics" ]
W2081360555
Small-Business Employment in 22 Rich Economies
Opponents of health care reform in the United States have often argued that such reform will be detrimental to small and medium-sized enterprises. The authors review the most recent data from a sample of 22 rich countries in the Organization for Economic Cooperation and Development (OECD), all of which, except the Unit...
[ "Individuals, Markets and Organisations" ]
W319328459
Alfalfa on Corn-Belt Farms...
Alfalfa, on Corn Belt farms, if introduced in any considerable acreage, requires a great amount of labor at the most critical stage of the cultivation of corn. This bulletin tells how the more successful Corn Belt growers fit alfalfa into their cropping systems without interfering seriously with labor schedules. This i...
[ "Products and Processes Engineering", "Earth System Science" ]
279579
Hot and dense QCD in the LHC era
QCD, the theory of strong interactions, has been defined as our most perfect physical theory, in part because its compact and apparently simple Lagrangian hides a plethora of emerging phenomena. The aim of the present project is to make the essential contributions to fully exploit the new possibilities of the Large Had...
[ "Fundamental Constituents of Matter", "Computer Science and Informatics" ]
10.1371/journal.pbio.2004718
Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation
Sarcomeres are stereotyped force-producing mini-machines of striated muscles. Each sarcomere contains a pseudocrystalline order of bipolar actin and myosin filaments, which are linked by titin filaments. During muscle development, these three filament types need to assemble into long periodic chains of sarcomeres calle...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1038/ncomms10646
Integrating geological archives and climate models for the mid-Pliocene warm period
The mid-Pliocene Warm Period (mPWP) offers an opportunity to understand a warmer-than-present world and assess the predictive ability of numerical climate models. Environmental reconstruction and climate modelling are crucial for understanding the mPWP, and the synergy of these two, often disparate, fields has proven e...
[ "Earth System Science", "Computer Science and Informatics" ]
W1974406002
Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice
We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and gamma-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Single administration of FBEP and GABA dose-dependently r...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases" ]
W2085155109
Barriers, benefits and motivation factors for the implementation of food safety management system in the food sector in Harare Province, Zimbabwe
The food manufacturing sector in Zimbabwe is dominated by small scale companies and most of these companies do not have food safety management systems. The barriers and motivation factors towards the implementation of Food Safety Management Systems (FSMS) such as Hazards Analysis and Critical Control Points (HACCP) and...
[ "Individuals, Markets and Organisations", "Products and Processes Engineering" ]
TW 105138147 A
Photo-imageable thin films with high dielectric constants
A formulation for preparing a photo-imageable film; said formulation comprising: (a) a positive photoresist comprising a cresol novolac resin and a diazonaphthoquinone inhibitor; and (b) functionalized zirconium oxide nanoparticles.
[ "Synthetic Chemistry and Materials", "Materials Engineering" ]
10.1038/NNANO.2015.108
Strain Induced Coupling Of Electrical Polarization And Structural Defects In Srmno3 Films
Local perturbations in complex oxides, such as domain walls, strain and defects, are of interest because they can modify the conduction or the dielectric and magnetic response, and can even promote phase transitions. Here, we show that the interaction between different types of local perturbations in oxide thin films i...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
US 2007/0080789 W
MODULAR DECK LID HINGE WITH COIL SPRINGS
A vehicle body decklid hinge includes at least one hinge set carried by a bracket that retains a pivot pin and a retainer bar in a cantilevered manner. The pivot pin supports a lever, such as a gooseneck strap, that will be coupled to the hood, while the bracket includes a mount that will be carried by peripheral body ...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.3389/fnhum.2016.00041
Alpha-band oscillations reflect altered multisensory processing of the McGurk illusion in Schizophrenia
The formation of coherent multisensory percepts requires integration of stimuli across the multiple senses. Patients with schizophrenia (ScZ) often experience a loss of coherent perception and hence, they might also show dysfunctional multisensory processing. In this high-density electroencephalography study, we invest...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1016/j.cortex.2018.09.011
Classical paintings may trigger pain and pleasure in the gendered brain
The human body is the most common object of pictorial representation in western art and its representations trigger a vast range of experiences from pain to pleasure. The goal of this study was to investigate brain activity triggered by paintings of male and female body images exemplifying conditions associated with pl...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
W2040495989
Incident radiation and the allocation of nitrogen within Arctic plant canopies: implications for predicting gross primary productivity
Arctic vegetation is characterized by high spatial variability in plant functional type (PFT) composition and gross primary productivity (P). Despite this variability, the two main drivers of P in sub-Arctic tundra are leaf area index (LT ) and total foliar nitrogen (NT ). LT and NT have been shown to be tightly couple...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
10.1142/S0218271816410133
Dimensional Reduction In Numerical Relativity Modified Cartoon Formalism And Regularization
We present in detail the Einstein equations in the Baumgarte–Shapiro–Shibata–Nakamura formulation for the case of D-dimensional spacetimes with SO(D−d) isometry based on a method originally introduced in Ref. 1. Regularized expressions are given for a numerical implementation of this method on a vertex centered grid in...
[ "Fundamental Constituents of Matter", "Mathematics" ]
10.1088/2515-7647/abb0ef
Few-cycle high-harmonic generation in liquids: In-operando thickness measurement of flat microjets
Extreme ultraviolet high-harmonic generation (HHG) from bulk liquids has only recently been demonstrated (T. T. Luu, Z. Yin et al, Nat. Comm. 9, 3724, (2018)). This has opened new prospects for the development of bright high-harmonic sources and the development of liquid-phase high-harmonic spectroscopy (HHS). Here, ...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.4161/hv.8.1.18672
Influenza viruses: From birds to humans
Avian influenza viruses are the precursors of human influenza A viruses. They may be transmitted directly from avian reservoirs, or infect other mammalian species before subsequent transmission to their human host. So far, avian influenza viruses have caused sporadic - yet increasingly more frequently recognized - case...
[ "Immunity, Infection and Immunotherapy", "Environmental Biology, Ecology and Evolution" ]
10.1080/13621025.2012.698514
The Heterogeneous World Of The Citizen
In response to the broad range of approaches given by this Special Issue, this article offers a critical post-colonial view on the question of citizenship after orientalism. Drawing on the historical trajectory of the emergence of the citizen in India through the era of anti-colonial struggle and beyond into that of th...
[ "Texts and Concepts", "The Social World and Its Interactions", "The Study of the Human Past" ]
CA 3058384 A
MULTI-PLY KNIT FABRIC
A multi-ply knit fabric (10) containing a first knit ply (100) and a second knit ply (200). The first knit ply (100) contains a plurality of first yarns and forms the upper surface (10a) of the fabric (10). The second knit ply (200) forms the lower surface (10b) of the fabric (10) and contains a plurality of polytetraf...
[ "Synthetic Chemistry and Materials", "Materials Engineering" ]
10.1051/0004-6361/201527579
Reconstructing The History Of Water Ice Formation From Hdo H2O And D2O Hdo Ratios In Protostellar Cores
Recent interferometer observations have found that the D2O/HDO abundance ratio is higher than that of HDO/H2O by about one order of magnitude in the vicinity of low-mass protostar NGC 1333-IRAS 2A, where water ice has sublimated. Previous laboratory and theoretical studies show that the D2O/HDO ice ratio should be lowe...
[ "Physical and Analytical Chemical Sciences", "Universe Sciences" ]
W1996288390
Polybrominated diphenyl ethers fate in China: A review with an emphasis on environmental contamination levels, human exposure and regulation
Because of their highly effective flame-retardant capability, polybrominated diphenyl ethers (PBDEs) have been extensively used as flame retardants in consumer goods. However, compelling evidence shows that many congeners of PBDEs have been accumulating in the environment, in biota and in human populations worldwide. I...
[ "Environmental Biology, Ecology and Evolution", "Physical and Analytical Chemical Sciences", "Earth System Science", "Institutions, Governance and Legal Systems" ]
W1990624991
Disaggregation of component soil series on an Ohio County soil survey map using possibilistic decision trees
Abstract Data mining from existing County soil surveys can improve the utility of maps for research, management and decision making. Aggregated soil series information in soil survey map units can be disaggregated by following a possibilistic decision tree approach to provide maps at the soil series level. The “overall...
[ "Earth System Science", "Computer Science and Informatics" ]
206875
Regulation and function of non-coding RNAs in epigenetic processes: the paradigm of X-chromosome inactivation
Some 150 years after the emergence of genetics, epigenetic mechanisms are increasingly understood to be fundamental players in phenotype transmission and development. In addition, epigenetic alterations are now linked to several human diseases including cancers. A common feature of many epigenetic phenomena, for which ...
[ "Integrative Biology: from Genes and Genomes to Systems", "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1038/nmat4318
In situ NMR and electrochemical quartz crystal microbalance techniques reveal the structure of the electrical double layer in supercapacitors
Supercapacitors store charge through the electrosorption of ions on microporous electrodes. Despite major efforts to understand this phenomenon, a molecular-level picture of the electrical double layer in working devices is still lacking as few techniques can selectively observe the ionic species at the electrode/elect...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1007/978-3-319-61467-0_10
Testing A Saturation Based Theorem Prover Experiences And Challenges
This paper attempts to address the question of how best to assure the correctness of saturation-based automated theorem provers using our experience with developing the theorem prover Vampire. We describe the techniques we currently employ to ensure that Vampire is correct and use this to motivate future challenges tha...
[ "Computer Science and Informatics" ]
185469
Glass recovering revolution: high performance optical sorter for glass collection from waste
The amount of Municipal Solid Waste (MSW) in the EU28 reached 245 million tons in 2012. Nowadays, Europe directives for waste management are more restrictive each year (e.g Landfill Directive 1999/31/EC), but unfortunately, landfill disposal still represents 34% of total MSW generated. On the other hand, citizen awaren...
[ "Products and Processes Engineering", "Materials Engineering", "Systems and Communication Engineering", "Computer Science and Informatics" ]
818791
Visual Culture, Piety and Propaganda: Transfer and Reception of Russian Religious Art in the Balkans and the Eastern Mediterranean (16th to early 20th Century)
The Russian religious artefacts (icons and ecclesiastical furnishings) held in museums, church or monastery collections in the Balkans and Eastern Mediterranean constitute a body of valuable monuments hitherto largely neglected by historians and historians of art. These objects acquire various interrelated religious/id...
[ "The Study of the Human Past", "Studies of Cultures and Arts" ]
W2108104440
Cambodia's Fertility Transition: The Dynamics of Contemporary Childbearing
Cambodia is undergoing a fertility transition with the total fertility rate falling from 6.7 before 1970 to 3.0 in 2010. This study is the first to examine the contemporary context of childbearing in Cambodia and the drivers of this transition analyzing the articulations of men and women and the rationales behind their...
[ "Human Mobility, Environment, and Space", "The Social World and Its Interactions", "The Human Mind and Its Complexity" ]