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10.1890/14-0106.1
The Influence Of Birth Date Via Body Mass On Individual Fitness In A Long Lived Mammal
The timing of birth has marked impacts on early life and early development of newborns in many species. In seasonal environments, early-born offspring often survive and grow better than late-born offspring, but despite the long-lasting effects of early conditions on life history traits, the influence of birth date on f...
[ "Environmental Biology, Ecology and Evolution", "Physiology in Health, Disease and Ageing" ]
10.1016/j.rmed.2013.09.010
Lymphocyte subsets in experimental rhinovirus infection in chronic obstructive pulmonary disease
Background: COPD is associated with increased numbers of T cells in the lungs, particularly CD8+ T cells. The mechanisms of increased T cells are unknown but may be related to repeated virus infections in COPD patients. We analysed lymphocyte subsets in blood and bronchoalveolar lavage in smokers and COPD subjects duri...
[ "Physiology in Health, Disease and Ageing", "Immunity, Infection and Immunotherapy" ]
10.1039/C004246C
Rapid Prototyping Of Microfluidic Devices For Integrating With Ft Ir Spectroscopic Imaging
A versatile approach for the rapid prototyping of microfluidic devices suitable for use with FT-IR spectroscopic imaging is introduced. Device manufacture is based on the direct printing of paraffin onto the surface of an infrared transparent substrate, followed by encapsulation. Key features of this approach are low r...
[ "Physical and Analytical Chemical Sciences", "Products and Processes Engineering", "Materials Engineering" ]
W392251796
Heat transfer investigation in rotating smooth square U-duct with different wall-temperature ratios and channel orientations
Abstract Effect of wall-temperature ratios (TR) and channel orientations (β) on heat transfer in rotating smooth square U-duct is experimentally investigated. The inlet Reynolds number and rotation number (Ro) range from 10,000 to 30,000 and 0 to 2.0, respectively. Three TR cases (0.08, 0.12, and 0.16) and two channel ...
[ "Products and Processes Engineering", "Condensed Matter Physics" ]
10.1145/3275519
Feature Specific Profiling
While high-level languages come with significant readability and maintainability benefits, their performance remains difficult to predict. For example, programmers may unknowingly use language features inappropriately, which cause their programs to run slower than expected. To address this issue, we introduce feature-s...
[ "Computer Science and Informatics" ]
10.1093/cercor/bhy003
The Temporal Dynamics of Brain Plasticity in Aging
Cognitive training has been suggested as a possible remediation of decline in brain structure with older age. However, it is unknown whether training effects are transient or enduring, as no studies have examined training-induced plasticity relative to decline in older adults across extended periods with multiple inter...
[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing" ]
10.1021/acs.est.0c00525
No Evidence for a Significant Impact of Heterogeneous Chemistry on Radical Concentrations in the North China Plain in Summer 2014
The oxidation of nitric oxide to nitrogen dioxide by hydroperoxy (HO2) and organic peroxy radicals (RO2) is responsible for the chemical net ozone production in the troposphere and for the regeneration of hydroxyl radicals, the most important oxidant in the atmosphere. In Summer 2014, a field campaign was conducted in ...
[ "Physical and Analytical Chemical Sciences", "Earth System Science" ]
339760
Non-Commutative Distributions in Free Probability
We intend to study new directions in free probability theory with high potential to lead to breakthroughs in our understanding of random matrix models and operator algebras. We will drive forward the study of ""free analysis"" which is intended to provide a whole new mathematical theory for variables with the highest d...
[ "Mathematics" ]
EP 2022075812 W
COMPUTER-IMPLEMENTED OBJECT VISIBILITY IMPROVEMENT BY INTERPOSING AN IMAGE IN A VIEWER'S LINE-OF-SIGHT
Object overlay for vehicle occupants includes determining that visibility of an object in a view of a vehicle occupant through a transparent surface of the vehicle is degraded, the object being in an environment in which the vehicle travels, selecting from an image repository a reference image of the object, extracting...
[ "Products and Processes Engineering", "Computer Science and Informatics" ]
3743511
A citizen science decade (2020-2030) in support to the sustainable development goals
The CS-SDG project will lead to the organization of a citizen science conference which will bring together and showcase impactful citizen science initiatives, provide policy input to ongoing European developments and inspire the upcoming ten years of citizen science initiatives. CS-SDG will address this challenge by fo...
[ "The Social World and Its Interactions", "Institutions, Governance and Legal Systems", "Environmental Biology, Ecology and Evolution" ]
10.1016/j.cortex.2018.11.023
Synaesthetes show advantages in savant skill acquisition: Training calendar calculation in sequence-space synaesthesia
Previous research has suggested that synaesthetic experiences may create the foundation for superior skills to emerge of the type found in savant syndrome (e. g. , Simner, Mayo, & Spiller, 2009). People with sequence-space synaesthesia experience units of time (e. g. , days, months, years) as a pattern in space, either...
[ "The Human Mind and Its Complexity", "Neuroscience and Disorders of the Nervous System" ]
interreg_1360
Monitoring, forcasting and best practices for FLOOD Mitigation and prevEntion in the CADSES region
Hydro-meteorological monitoring and flood forecasting are indispensable for preventing and mitigating hydrological hazards, such as floods, and for ensuring civil protection. Implementing a plan that acknowledges the principles of sustainability to combat floods requires further activities regarding agriculture, forest...
[ "Earth System Science", "Products and Processes Engineering", "Human Mobility, Environment, and Space" ]
949229
Crystal Engineering the New Generation of Sustainable, Biocompatible and Stimuli Responsive Formulations for the Delivery of Active Ingredients
CryForm aims at progressing our fundamental knowledge in organic materials crystallization and crystal engineering by: (1) gleaning a mechanistic understanding of the relationship between crystal structure and surface properties; (2) uncovering the thermodynamic and kinetic mechanisms of crystal nucleation and growth a...
[ "Materials Engineering", "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences", "Products and Processes Engineering", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1080/13506285.2019.1582571
Memory Based Attentional Biases Survive Spatial Suppression Driven By Selection History
Information in visual working memory that is only prospectively relevant can nevertheless guide attention towards memory matching visual input. Previous studies demonstrated that such memory-based . . .
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1126/sciadv.aar6444
Probing measurement-induced effects in quantum walks via recurrence
Measurements on a quantum particle unavoidably affect its state, since the otherwise unitary evolution of the system is interrupted by a nonunitary projection operation. To probe measurement-induced effects in the state dynamics using a quantum simulator, the challenge is to implement controlled measurements on a small...
[ "Fundamental Constituents of Matter", "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
10.1007/s11229-016-1062-8
Malfunction defended
Historical accounts of biological are thought to have, as a point in their favour, their being able to accommodate malfunction. Recently, this has been brought into doubt by Paul Sheldon Davies’s argument for the claim that both selected malfunction (that of the selected functions account) and weak etiological malfunct...
[ "Texts and Concepts" ]
10.1007/JHEP09(2015)088
Rigid 4D N 2 Supersymmetric Backgrounds And Actions
We classify all N=2 rigid supersymmetric backgrounds in four dimensions with both Lorentzian and Euclidean signature that preserve eight real supercharges, up to discrete identifications. Among the backgrounds we find specific warpings of S^3 x R and AdS_3 x R, AdS_2 x S^2 and H^2 x S^2 with generic radii, and some mor...
[ "Fundamental Constituents of Matter", "Mathematics" ]
340642
Transgressive Inheritance in plant Breeding and Evolution
New varieties of plant and animal are produced by hybridisation of closely related varieties or species. This process generates ""transgressive"" traits that are outside the parental range. Transgressive phenotypes in hybrids may involve complementation of genetic differences between the two parents, heterozygous adva...
[ "Integrative Biology: from Genes and Genomes to Systems", "Environmental Biology, Ecology and Evolution", "Biotechnology and Biosystems Engineering" ]
10.1007/JHEP08(2014)044
The Gravity Dual Of Supersymmetric Gauge Theories On A Squashed S 1 S 3
We present a new one-parameter family of supersymmetric solutions deform- ing AdS5. This is constructed as an asymptotically locally anti de Sitter (AlAdS) solution ofve-dimensional minimal gauged supergravity, with topology RR 4 and a non-trivial graviphotoneld, and can be uplifted to ten or eleven dimensional supergr...
[ "Fundamental Constituents of Matter", "Mathematics" ]
268757
The genomic blueprint of macrophages: dissecting players and mechanisms through an integrative approach
Macrophages are highly specialized cells widely distributed in tissues and active both as immune effectors and as housekeeping phagocytes responsible for maintenance of tissue integrity. Macrophages display a striking heterogeneity that reflects a complex interplay between different micro-environmental signals provided...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1088/1742-6596/200/1/012207
Kinks Fingerprints Of Strong Electronic Correlations
The textbook knowledge of solid state physics is that the electronic specific heat shows a linear temperature dependence with the leading corrections being a cubic term due to phonons and a cubic-logarithmic term due to the interaction of electrons with bosons. We have shown that this longstanding conception needs to b...
[ "Condensed Matter Physics" ]
US 2015/0027039 W
IMPROVED PERMEABILITY OF SUBTERRANEAN RESERVOIRS USING ACID DIVERSION
Methods for acid diversion in a hydrocarbon-containing subterranean formation are disclosed. The methods include injecting an acid diversion agent comprising a water-soluble or dispersible branched polyhydroxyetheramine and injecting an acidic solution into a well which is in contact with the hydrocarbon- containing su...
[ "Products and Processes Engineering", "Physical and Analytical Chemical Sciences" ]
10.1142/S0218301316300058
Predictions For P Pb Collisions At Sqrt S_ Nn 5 Tev Comparison With Data
Predictions made in Albacete et al. [Int. J. Mod. Phys. E 22 (2013) 1330007] prior to the LHC p+Pb run at sNN = 5 TeV are compared to currently available data. Some predictions shown here have been updated by including the same experimental cuts as the data. Some additional predictions are also presented, especially f...
[ "Fundamental Constituents of Matter" ]
10.1162/jocn_a_00512
Resting State Correlates of Subdimensions of Anxious Affect
Resting state fMRI may help identify markers of risk for affective disorder. Given the comorbidity of anxiety and depressive disorders and the heterogeneity of these disorders as defined by DSM, an important challenge is to identify alterations in resting state brain connectivity uniquely associated with distinct profi...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1038/mi.2012.69
Natural and long-lasting cellular immune responses against influenza in the M2e-immune host
Influenza is a global health concern. Licensed influenza vaccines induce strain-specific virus-neutralizing antibodies but hamper the induction of possibly cross-protective T-cell responses upon subsequent infection. 1 In this study, we compared protection induced by a vaccine based on the conserved extracellular domai...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1073/pnas.1910097116
Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells
Invariant NKT (iNKT) cells have the unique ability to shape immunity during antitumor immune responses and other forms of sterile and nonsterile inflammation. Recent studies have highlighted a variety of classes of endogenous and pathogen-derived lipid antigens that can trigger iNKT cell activation under sterile and no...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
679355
Bird Inspired Autonomous Flight
The agile and efficient flight of birds shows what flight performance is physically possible, and in theory could be achieved by unmanned air vehicles (UAVs) of the same size. The overall aim of this project is to enhance the performance of small scale UAVs by developing novel technologies inspired by understanding how...
[ "Products and Processes Engineering", "Computer Science and Informatics", "Materials Engineering" ]
10.1080/17445647.2016.1197613
Late Glacial And Holocene European Pollen Data
The European Pollen Database (EPD) is a community effort to archive and make available pollen sequences from across the European continent. Pollen sequences provide records that may be used to infer past vegetation and vegetation change. We present here maps based on 828 sites from the EPD giving an overview of changes...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
W2012610289
Novel and functional variants within the TBX18 gene promoter in ventricular septal defects
Congenital heart disease (CHD) is the most common birth defect in humans. Genetic causes for CHD remain largely unknown. T-box transcription factor 18 (TBX18) gene is expressed in the developing heart, including myocardium of the left ventricle and interventricular septum. Epicardial cells expressing TBX18 gene contrib...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1186/gb-2013-14-4-r33
Systematic biases in DNA copy number originate from isolation procedures
Background: The ability to accurately detect DNA copy number variation in both a sensitive and quantitative manner is important in many research areas. However, genome-wide DNA copy number analyses are complicated by variations in detection signal. Results: While GC content has been used to correct for this, here we sh...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
W2011760939
Influence of baseline ejection fraction on the prognostic value of paravalvular leak after transcatheter aortic valve implantation
Moderate or severe paravalvular leak (PVL ≥ moderate) after transcatheter aortic valve implantation (TAVI) is associated with poor outcomes. The aim of this study was to assess whether the baseline ejection fraction (EF) affects the impact of PVL on mortality after TAVI.We analyzed 514 consecutive patients with native ...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Physiology in Health, Disease and Ageing" ]
interreg_4045
eGovernment for Regional Development and Interregional Cooperation
The European regional policy, as formulated in the programming period 2000 – 2006, has a clear priority on Information Society (IS). All regions are able to contribute to IS. The recent trend in governmental services and public administration is the amplification of decentralization; for this reason eGovernment and IS ...
[ "Computer Science and Informatics", "Institutions, Governance and Legal Systems", "Individuals, Markets and Organisations" ]
279401
Video and 3D Analysis for Visual Learning
Reliable recognition of thousands of object and action categories is today's key challenge in computer vision. Most contemporary approaches are based on supervised learning algorithms to train object classifiers. While manual annotation has become easier in recent years, it is still not scalable to a large set of categ...
[ "Computer Science and Informatics", "Systems and Communication Engineering", "Products and Processes Engineering" ]
10.3389/fimmu.2014.00383
Post-translational modifications of exosomal proteins
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Immunity, Infection and Immunotherapy" ]
10.1145/3077981.3078032
Datasets For The Analysis Of Expressive Musical Gestures
In this paper we present two datasets of instrumental gestures performed with expressive variations: five violinists performing standard pedagogical phrases with variation in dynamics and tempo; and two pianists performing a repertoire piece with variations in tempo, dynamics and articulation. We show the utility of th...
[ "Computer Science and Informatics", "Systems and Communication Engineering" ]
10.1063/1.4878836
Phase Separation In Solutions With Specific And Nonspecific Interactions
Protein solutions, which tend to be thermodynamically stable under physiological conditions, can demix into protein-enriched and protein-depleted phases when stressed. Using a lattice-gas model of proteins with both isotropic and specific, directional interactions, we calculate the critical conditions for phase separat...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
W2541750647
A soft damping function for dispersion corrections with less overfitting
The use of damping functions in empirical dispersion correction schemes is common and widespread. These damping functions contain scaling and damping parameters, and they are usually optimized for the best performance in practical systems. In this study, it is shown that the overfitting problem can be present in curren...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.1172/JCI70355
P53 Isoforms Regulate Aging And Tumor Associated Replicative Senescence In T Lymphocytes
Cellular senescence contributes to aging and decline in tissue function. p53 isoform switching regulates replicative senescence in cultured fibroblasts and is associated with tumor progression. Here, we found that the endogenous p53 isoforms Δ133p53 and p53β are physiological regulators of proliferation and senescence ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Immunity, Infection and Immunotherapy", "Physiology in Health, Disease and Ageing" ]
10.1364/OL.36.001833
High Sensitivity Compact Ultrasonic Detector Based On A Pi Phase Shifted Fiber Bragg Grating
A highly sensitive compact hydrophone, based on a pi-phase-shifted fiber Bragg grating, has been developed for the measurement of wideband ultrasonic fields. The grating exhibits a sharp resonance, whose centroid wavelength is pressure sensitive. The resonance is monitored by a continuous-wave (CW) laser to measure ult...
[ "Condensed Matter Physics", "Systems and Communication Engineering" ]
10.1042/BCJ20160107
When Fast Is Better Protein Folding Fundamentals And Mechanisms From Ultrafast Approaches
Protein folding research stalled for decades because conventional experiments indicated that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay between dynamics and energetics resulting in myriad microscopic pathways. Ultrafast kinetic methods turned the field upside down by provid...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences" ]
10.1007/978-3-030-35888-4_9
Robots Improve Judgments On Self Generated Actions An Intentional Binding Study
In near future, robots will become a fundamental part of our daily life; therefore, it appears crucial to investigate how they can successfully interact with humans. Since several studies already pointed out that a robotic agent can influence human’s cognitive mechanisms such as decision-making and joint attention, we ...
[ "Computer Science and Informatics", "The Human Mind and Its Complexity" ]
US 201313751430 A
LARGE-CURRENT MICRO-WIRE PATTERN
A pattern of micro-wires forming an electrical conductor includes a plurality of spaced-apart first micro-wires extending in a first direction. A plurality of spaced-apart second micro-wires extends in a second direction different from the first direction. Each second micro-wire is electrically connected to at least tw...
[ "Systems and Communication Engineering", "Materials Engineering" ]
10.3390/rs12040602
Mapping the Land Cover of Africa at 10 m Resolution from Multi-Source Remote Sensing Data with Google Earth Engine
The remote sensing based mapping of land cover at extensive scales, e. g. , of whole continents, is still a challenging task because of the need for sophisticated pipelines that combine every step from data acquisition to land cover classification. Utilizing the Google Earth Engine (GEE), which provides a catalog of mu...
[ "Computer Science and Informatics", "Earth System Science" ]
US 61740509 A
Downhole progressive pressurization actuated tool and method of using the same
A method of servicing a subterranean formation comprising positioning a wellbore servicing tool comprising an axial flowbore within a wellbore, making a first application of pressure to the axial flowbore of the wellbore servicing tool; wherein the pressure within the wellbore servicing tool is at least a first upper t...
[ "Products and Processes Engineering", "Materials Engineering" ]
616732
Holographic Quantum Cosmology
The current theory of cosmic inflation is largely based on classical physics. This undermines its predictivity in a world that is fundamentally quantum mechanical. With this project we will develop a novel approach towards a quantum theory of inflation. We will do this by introducing holographic techniques in cosmology...
[ "Universe Sciences", "Fundamental Constituents of Matter" ]
10.3389/fmicb.2019.01355
Staphylococcus aureus uses the bacilliredoxin (BrxAB)/bacillithiol disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections
Staphylococcus aureus is a major human pathogen and has to cope with reactive oxygen and chlorine species (ROS, RCS) during infections. The low molecular weight thiol bacillithiol (BSH) is an important defense mechanism of S. aureus for detoxification of ROS and HOCl stress to maintain the reduced state of the cytopla...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
169478
Effect of land use induced shifts in soil microbial diversity and function on carbon cycling in soil
The need for improved food production for the growing population has led to increase in planet’s arable land cover. Many studies suggest that such practices lead to loss of soil organic carbon (C) – a relatively large C pool with a fast response time. Thus there is a need to manage soils sustainably in order to mitigat...
[ "Environmental Biology, Ecology and Evolution", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Earth System Science" ]
221226
Castor edc: unlocking the potential of data in biomedical research
A large part of the data collected during the biomedical research is wasted, because there is no affordable and easy-to-use Electronic Data Capture (EDC) tool for clinical trials. As a result, 85% of the research investment in the biomedical research domain – equating to $200 billion – is dissipated. Castor is a disrup...
[ "Computer Science and Informatics", "Prevention, Diagnosis and Treatment of Human Diseases" ]
IB 2019060558 W
APPARATUS FOR THE WEEDING OF SOILS
The apparatus (1) for the weeding of soils comprises: - an irradiation assembly (2) adapted to generate microwaves and to convey them onto a soil to be weeded; - a management and control unit (3) of the apparatus (1); - a power supply unit (4) connected to the irradiation assembly (2) and to the management and control ...
[ "Products and Processes Engineering", "Systems and Communication Engineering" ]
W2341229356
Pelagic seascape ecology for operational fisheries oceanography: modelling and predicting spawning distribution of Atlantic bluefin tuna in Western Mediterranean
Abstract The ecology of highly migratory marine species is tightly linked to dynamic oceanographic processes occurring in the pelagic environment. Developing and applying techniques to characterize the spatio-temporal variability of these processes using operational oceanographic data is a challenge for management and ...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
10.1038/s41596-019-0225-8
Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D
The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of limitations in ECM visualization. We recently developed an ECM-specialized method termed in situ decellularization of tissues (ISDoT) to isolate native 3D ECM scaffolds fr...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Biotechnology and Biosystems Engineering" ]
223193
Paradoxes and metaphors of time in early universe(s)
PROTEUS studies main strategies devised by Western philosophy in representing time in cosmology. It aims at modifying current metaphysics and its relationship with cosmology in the light of recent scientific debates in quantum gravity and quantum cosmology, thereby boosting a new research field in history and philosoph...
[ "Universe Sciences", "Texts and Concepts" ]
2719721
Hybrid electric small commuter aircraft conceptual design
This thematic topic focuses on the design of a 19 passenger commuter aircraft based on alternative propulsion concepts (hybrid/electric) targeting near-zero CO2 emissions. A full design loop is required, evaluating a range of design options, resulting in a mature conceptual design for the selected design. The design sh...
[ "Products and Processes Engineering", "Systems and Communication Engineering" ]
10.1093/texcom/tgaa062
Automatic Segmentation of the Dorsal Claustrum in Humans Using in vivo High-Resolution MRI
Abstract The claustrum is a thin sheet of neurons enclosed by white matter and situated between the insula and the putamen. It is highly interconnected with sensory, frontal, and subcortical regions. The deep location of the claustrum, with its fine structure, has limited the degree to which it could be studied in vivo...
[ "Neuroscience and Disorders of the Nervous System", "Computer Science and Informatics" ]
10.1364/OE.22.007711
Stray Light Suppression In Spectroscopy Using Periodic Shadowing
It is well known that spectroscopic measurements suffer from an interference known as stray light, causing spectral distortion that reduces measurement accuracy. In severe situations, stray light may even obscure the existence of spectral lines. Here a novel general method is presented, named Periodic Shadowing, that e...
[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
10.1038/gene.2010.41
PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients
Cystic fibrosis (CF) is a common life-threatening autosomal recessive disorder in the Caucasian population, and the gene responsible is the CF transmembrane conductance regulator (CFTR). Patients with CF have repeated bacterial infection of the airways caused by Pseudomonas aeruginosa (PA), which is one of the predomin...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1088/0004-637X/780/2/123
Moa 2008 Blg 379Lb A Massive Planet From A High Magnification Event With A Faint Source
We report on the analysis of the high microlensing event MOA-2008-BLG-379, which has a strong microlensing anomaly at its peak due to a massive planet with a mass ratio of q = 6. 9 × 10–3. Because the faint source star crosses the large resonant caustic, the planetary signal dominates the light curve. This is unusual f...
[ "Universe Sciences" ]
10.1093/toxsci/kfy058
Prediction of drug-induced hepatotoxicity using long-term stable primary hepatic 3D spheroid cultures in chemically defined conditions
High failure rates of drug candidates in the clinics, restricted-use warnings as well as withdrawals of drugs in postmarketing stages are of substantial concern for the pharmaceutical industry and drug-induced liver injury (DILI) constitutes one of the most frequent reasons for such safety failures. Importantly, as DIL...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1016/j.jet.2011.10.009
Pre-sale information
In markets as diverse as that for specialized industrial equipment or that for retail financial services, sellers or intermediaries may earn profits both from the sale of products and from the provision of pre-sale consultation services. We study how a seller optimally chooses the costly quality of pre-sale information...
[ "Individuals, Markets and Organisations" ]
GB 173725 A
Improvements in or relating to means for locking doors
247,720. Imber, J. Jan. 20, 1925. Latches, sliding; striking-plates for locks and latches.-A sliding bolt is formed with a recessed end g adapted to engage, under spring pressure, a fixed socket p having a central projection q. The edges of the bolt and socket projection are rounded and the surfaces inclined to the axi...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1091/mbc.E12-09-0642
CD81 regulates cell migration through its association with Rac GTPase
CD81 is a member of the tetraspanin family that has been described to have a key role in cell migration of tumor and immune cells. To unravel the mechanisms of CD81-regulated cell migration, we performed proteomic analyses that revealed an interaction of the tetraspanin C-terminal domain with the small GTPase Rac. Dire...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2372379898
Difference of Regional Economic Cycle of Large Country:Taking Chinese Provincial Data as an Example
Exploring the development of large country economy has become one of the hot issues in academic research nowadays. Taking typical large country―China as the research object, the paper studies the difference of regional economic cycle of large country in the light of 6 indexes in three aspects of cycle length, depth, an...
[ "Individuals, Markets and Organisations" ]
10.1177/0950017015598283
Work Interruptions And Young Women S Career Prospects In Germany Sweden And The Us
This article assesses the impact of discontinuous work histories on young women’s occupational mobility in Germany, Sweden and the US. Women with continuous work histories are compared with those w. . .
[ "The Social World and Its Interactions", "Individuals, Markets and Organisations" ]
10.1038/nature22899
Linking the influence and dependence of people on biodiversity across scales
Biodiversity enhances many of nature's benefits to people, including the regulation of climate and the production of wood in forests, livestock forage in grasslands and fish in aquatic ecosystems. Yet people are now driving the sixth mass extinction event in Earth's history. Human dependence and influence on biodiversi...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
220618
Measures for behaving safely in traffic
Navigating traffic is mostly habitual; Our behaviour neither requires a lot of elaborate conscious decision-making, nor is it purely automatic/reflexive. However, most current measures intended to get traffic users to behave safer appeal to our deliberate self (awareness campaigns, speed signs), act autonomously on our...
[ "Products and Processes Engineering", "Systems and Communication Engineering", "Computer Science and Informatics" ]
216804
Gn4-2 research and education networking - géant
GN4-2 is the proposed project for the second Specific Grant Agreement under the 68-month Framework Partnership Agreement (FPA) established between the GÉANT Consortium and the European Commission in April 2015.This second phase of implementing the FPA will raise European research to the next level by promoting scientif...
[ "Computer Science and Informatics", "Systems and Communication Engineering" ]
894553
Climate positive drying system for coffee industries using a highly disruptive pyrolysis technology
PYROTECH is based on a highly disruptive pyrolysis technology as a heating source for drying coffee cherries and makes it possible to produce biochar (a fertilizer used in coffee agriculture). It will displace the market’s “dry methods” for processing coffee, which involves sun drying or the use of heat coming from a c...
[ "Products and Processes Engineering", "Environmental Biology, Ecology and Evolution" ]
10.18632/oncotarget.11719
The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas
The oncogenic transcription factor Myc is required for the progression and maintenance of diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or associated biological processes might constitute prime targets for cancer therapy. Here, we present an in vivo reverse-genetic screen tar...
[ "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1515/sagmb-2013-0077
Bayesian modelling of compositional heterogeneity in molecular phylogenetics
In molecular phylogenetics, standard models of sequence evolution generally assume that sequence composition remains constant over evolutionary time. However, this assumption is violated in many datasets which show substantial heterogeneity in sequence composition across taxa. We propose a model which allows compositio...
[ "Mathematics", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Computer Science and Informatics" ]
10.1007/978-3-319-94676-4_8
Reduced Basis Approximation And A Posteriori Error Estimation Applications To Elasticity Problems In Several Parametric Settings
In this work we consider (hierarchical, Lagrange) reduced basis approximation and a posteriori error estimation for elasticity problems in affinely parametrized geometries. The essential ingredients of the methodology are: a Galerkin projection onto a low-dimensional space associated with a smooth “parametric manifold”...
[ "Mathematics", "Computer Science and Informatics", "Condensed Matter Physics", "Materials Engineering" ]
10.1155/2017/5985031
Modeling Of Tumor Growth Incorporating The Effects Of Necrosis And The Effect Of Bevacizumab
Tumor growth models are important to create an engineering background for cancer treatment either by using the models for simulations and evaluation of treatment protocols or, if combined with control engineering, by designing treatment protocols. A well-defined tumor growth model must describe the physiological proces...
[ "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Systems and Communication Engineering" ]
W2494322674
Sealing One's Online Wall Off From Outsiders
Pieces of personal information (e.g. contact details, photos, thoughts and opinions on issues and things) on online social network sites are susceptible to third-party surveillance. While users are provided with the possibility to prevent unwarranted access using available privacy settings, such settings may not often ...
[ "The Social World and Its Interactions", "Computer Science and Informatics" ]
648509
Large Discrete Structures
The proposed project seeks to introduce novel methods to analyze and approximate large graphs and other discrete structures and to apply the developed methods to solve specific open problems. A need for such methods comes from computer science where the sizes of input structures are often enormous. Specifically, the pr...
[ "Mathematics", "Computer Science and Informatics" ]
10.1016/j.gde.2020.05.008
African population history: an ancient DNA perspective
The history of human populations in Africa is complex and includes various demographic events that influenced patterns of genetic variation across the continent. Through genetic studies of modern-day, and most recently, ancient African genetic variation, it became evident that deep African history is captured by the re...
[ "Integrative Biology: from Genes and Genomes to Systems", "The Study of the Human Past" ]
10.18632/oncotarget.3680
uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery
Pre- and intraoperative diagnostic techniques facilitating tumor staging are of paramount importance in colorectal cancer surgery. The urokinase receptor (uPAR) plays an important role in the development of cancer, tumor invasion, angiogenesis, and metastasis and over-expression is found in the majority of carcinomas. ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
W2059235919
Rap and Revolt in the Arab World
This essay approaches the phenomenon of Arab rap music as an emergent form of cultural and communal intelligibility and solidarity; its simultaneous influence on and indebtedness to global hip-hop and youth cultural movements has transformed it into an increasingly transnational collaborative project, bringing together...
[ "The Social World and Its Interactions", "Studies of Cultures and Arts" ]
886047
Vaccines as a remedy for antimicrobial resistant bacterial infections
Antimicrobial Resistance (AMR) is perhaps the most emerging alarm in health. It already causes 700,000 deaths per year and the forecast for 2050 is 10 million deaths, more than cancer today. WHO, UN General Assembly, World Bank, G20, EU, UK and USA governments call for new antibiotics, but the pipeline for new antib...
[ "Immunity, Infection and Immunotherapy", "Prevention, Diagnosis and Treatment of Human Diseases", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1109/MMUL.2017.33
Multisensory Experiences In Hci
For decades, the use of vision and audition for interaction dominated the field of human-computer interaction (HCI), despite the fact that nature has provided many more senses for perceiving and interacting with the world. Recently, HCI researchers have started trying to capitalize on touch, taste, and smell when desig...
[ "Computer Science and Informatics", "The Human Mind and Its Complexity" ]
W2117584985
Canvassing conversations: obstinate issues in studies of elites and elite education
Studies of elites and elite education have largely not involved rigorous debate, either with regard to the conceptual resources deployed or methodologies adopted. Even the concepts elite and elite schools have not been problematized much. Further, there is a tendency for people to cite, rather than engage or dispute ea...
[ "The Social World and Its Interactions", "Texts and Concepts" ]
10.1002/adma.201703612
Nanomorphology Effects in Semiconductors with Native Ferromagnetism: Hierarchical Europium (II) Oxide Tubes Prepared via a Topotactic Nanostructure Transition
Semiconductors with native ferromagnetism barely exist and defined nanostructures are almost unknown. This lack impedes the exploration of a new class of materials characterized by a direct combination of effects on the electronic system caused by quantum confinement effects with magnetism. A good example is EuO for wh...
[ "Condensed Matter Physics", "Synthetic Chemistry and Materials", "Materials Engineering" ]
101002163
Managing Identities in Diverse Societies: A Developmental Intergroup Perspective with Adolescents
Ethnic and cultural diversity has sharply increased in modern societies due to migration processes. However, the implication of this for adolescents facing the core task of developing their identities are still mostly unknown. For both adolescents without and with a migrant background (e.g., recent refugees, second-gen...
[ "The Social World and Its Interactions", "The Human Mind and Its Complexity" ]
FR 2006002718 W
METHOD FOR CONTROLLING A PROCESS INVOLVING THE DEWAXING OF HYDROCARBON OILS
The invention relates to a method for controlling the dewaxing of an oil phase comprising a hydrocarbon oil which has been optionally diluted in at least one organic solvent. The inventive method includes the following steps namely: a step (a) comprising the formation of wax crystals in the above-mentioned phase, and a...
[ "Products and Processes Engineering", "Physical and Analytical Chemical Sciences" ]
10.1038/nri.2016.144
T cell responses in the central nervous system
T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there ...
[ "Neuroscience and Disorders of the Nervous System", "Immunity, Infection and Immunotherapy" ]
10.1145/1935826.1935923
Stochastic Query Covering
In this paper we introduce the problem of query covering as a means to efficiently cache query results. The general idea is to populate the cache with documents that contribute to the result pages of a large number of queries, as opposed to caching the top documents for each query. It turns out that the problem is hard...
[ "Computer Science and Informatics" ]
10.1073/pnas.1707845114
Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic cells prevent harmful R loops, we used human activation-induced cytidine deaminase (AID) to ide...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.3390/tropicalmed4010021
A Call for Systems Epidemiology to Tackle the Complexity of Schistosomiasis, Its Control, and Its Elimination
Ever since the first known written report of schistosomiasis in the mid-19th century, researchers have aimed to increase knowledge of the parasites, their hosts, and the mechanisms contributing to infection and disease. This knowledge generation has been paramount for the development of improved intervention strategies...
[ "Immunity, Infection and Immunotherapy", "Environmental Biology, Ecology and Evolution", "Integrative Biology: from Genes and Genomes to Systems" ]
W2073342895
Measures of Entropy and Change Point Analysis as Predictors of Post-Surgical Adverse Outcomes
A variety of adverse outcomes, such as kidney injury, death, cardiac injury, and respiratory failure affect a significant number of patients after surgery. Previous research has investigated possible predictors for these outcomes including features extracted from physiologic time series. This study builds upon this pre...
[ "Computer Science and Informatics", "Mathematics", "Prevention, Diagnosis and Treatment of Human Diseases", "Physiology in Health, Disease and Ageing" ]
10.1371/journal.pone.0142014
Resting-state fMRI functional connectivity is associated with sleepiness, imagery, and discontinuity of mind
Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. Non-sensory experiences are prevalent during rest and must arise f...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
US 202016952930 A
Filtering return points in a point cloud based on radial velocity measurement
Aspects and implementations of the present disclosure relate to filtering of return points from a point cloud based on radial velocity measurements. An example method includes: receiving, by a sensing system of an autonomous vehicle (AV), data representative of a point cloud comprising a plurality of return points, eac...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
W1915731335
A Study on Exports of Fish and Fish Products and their Role in Economic Growth of Pakistan
The objective of this study is to evaluate exports of fish and fisheries products and their importance in the ground of Pakistan's economy. Pakistani seafood has a significant export potential. A widespreaddiversity of commercially valued products are available. The results showed exports of Fish and fisheries products...
[ "Individuals, Markets and Organisations", "Environmental Biology, Ecology and Evolution" ]
W2028377739
Evaluation of supply chain performance using delivery-time performance analysis chart approach
Abstract Variability reduction and business synchronization are acknowledged as keys to achieving timely deliveries in supply chain networks. The evaluation of delivery performance is a crucial component in the overall management and time control of a supply chain. This study uses lead time, delivery window and deliver...
[ "Products and Processes Engineering", "Computer Science and Informatics" ]
2721507
Global gravity-based groundwater product
Groundwater is one of the most important freshwater resources for mankind and for ecosystems. Assessing groundwater resources and developing sustainable water management plans based on this resource is a major field of activity for science, water authorities and consultancies worldwide. Due to its fundamental role in t...
[ "Earth System Science", "Systems and Communication Engineering" ]
US 201213535107 A
IMPACT RESISTANT CLOSURE
A closure including a top panel and a transition section extending from a peripheral edge of the top panel is provided. The closure includes a skirt extending from a peripheral edge of the transition section such that the skirt extends away from the top panel. The skirt includes a plurality of projections extending out...
[ "Products and Processes Engineering", "Materials Engineering" ]
Q4767835
PROF. LUCIANO DI GIANDOMENICO
LA MIA ATTIVITA' PREVEDE LA PRODUZIONE MUSICALE COME COMPOSITORE, PIANISTA E DIRETTORE D'ORCHESTRA: BRANI MUSICALI ORIGINALI PER PUBBLICI CONCERTI, ARRANGIAMENTI MUSICALI, BASI MUSICALI, PRODUZIONI DI REGISTRAZIONI AUDIO E VIDEO MUSICALI, REALIZZAZIONI DI PARTITURE E SPARTITI MUSICALI PER EDITORIA E ESECUZIONE MUSICALE...
[ "Texts and Concepts", "Computer Science and Informatics" ]
994548
Ngos, transnational networks and the transformation of muslim communities in cambodia
Since the 1993 reinstallment of the monarchy after the devastating rule of the Khmer Rouge and the subsequent Vietnamese occupation, foreign NGOs have been mushrooming in Cambodia. Several among these are charities that are based in Malaysia and the Arabian Gulf, and which have become the core of Muslim transnational n...
[ "Studies of Cultures and Arts", "Human Mobility, Environment, and Space" ]
169966
Genetic and molecular priming approaches to increase crop strength and stress tolerance
The project provides advanced systems biology training for 5 ESRs who will develop novel methods for increasing crop strength and resistance to stress by alternative genetic and genomic, non-GMO, technologies: (1) Selecting allelic variants of a novel gene identified by members of the consortium which regulates oxidati...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Biotechnology and Biosystems Engineering" ]
W1999323575
Entrepreneurship education and boys' and girls' perceptions of entrepreneurs
There are many studies on the impacts of entrepreneurship education in higher education, but few studies have assessed how secondary schools can contribute to create a more dynamic enterprise culture. This paper assesses whether a European entrepreneurship programme directed at upper secondary school promote positive a...
[ "Individuals, Markets and Organisations", "The Social World and Its Interactions" ]
10.1111/mec.13681
Genomic analysis reveals depression due to both individual and maternal inbreeding in a free-living mammal population
There is ample evidence for inbreeding depression manifested as a reduction in fitness or fitness-related traits in the focal individual. In many organisms, fitness is not only affected by genes carried by the individual, but also by genes carried by their parents, for example if receiving parental care. While maternal...
[ "Environmental Biology, Ecology and Evolution", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1089/hs.2016.0118
Pricing Externalities to Balance Public Risks and Benefits of Research
How should scientific funders evaluate research with public health risks? Some risky work is valuable, but accepting too much risk may be ethically neglectful. Recent controversy over H5N1 influenza experiments has highlighted the difficulty of this problem. Advocates of the research claim the work is needed to underst...
[ "Individuals, Markets and Organisations", "Institutions, Governance and Legal Systems" ]
10.1109/TCSII.2011.2158165
A Subhertz Nanopower Low Pass Filter
This brief presents a first-order low-pass filter topology capable of providing cutoff frequencies down to 2 mHz with power consumption of 5 nW. The circuit is intended for signal conditioning applications, particularly for use with very low frequency physiological signals in low-power portable medical equipment. To ac...
[ "Systems and Communication Engineering", "Products and Processes Engineering" ]