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id stringlengths 6 42	title stringlengths 3 499	abstract stringlengths 0 6.24k	label listlengths 0 6
10.1093/nar/gkq801	Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus	Homing endonucleases recognize long target DNA sequences generating an accurate double-strand break that promotes gene targeting through homologous recombination. We have modified the homodimeric I-CreI endonuclease through protein engineering to target a specific DNA sequence within the human RAG1 gene. Mutations in R...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Immunity, Infection and Immunotherapy", "Integrative Biology: from Genes and Genomes to Systems", "Prevention, Diagnosis and Treatment of Human Diseases" ]
864877	Deep Earth Mantle Phase Transition Maps: Studied by Time-Resolved Experiments	Processes in Earth's lower mantle govern our planet's inner dynamics and control surface plate tectonics. As such, a quantitative understanding of the physical and chemical properties of the lower mantle is pivotal to model Earth’s dynamic evolution, including the long-term chemical interactions between mantle and atmo...	[ "Condensed Matter Physics", "Earth System Science" ]
10.1101/676189	Tailoring Cryo Electron Microscopy Grids By Photo Micropatterning For In Cell Structural Studies	Abstract Spatially-controlled cell adhesion on electron microscopy (EM) supports remains a bottleneck in specimen preparation for cellular cryo-electron tomography. Here, we describe contactless and mask-free photo-micropatterning of EM grids for site-specific deposition of extracellular matrix-related proteins. We att...	[ "Materials Engineering", "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
2730710	Ofi, pool management at your fingertips!	In ensuring safe, hygienic swimming environment, spas and pools need to be frequently checked and adjusted to maintain optimum levels of pH, chlorine/bromine/salt and water hardness. As most pool/spa owners perform the checks manually and constantly using visual analysis colorimetry-based solutions, users do not always...	[ "Products and Processes Engineering", "Systems and Communication Engineering", "Physical and Analytical Chemical Sciences", "Computer Science and Informatics" ]
10.1016/j.devcel.2017.08.002	YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis	Vascular endothelial growth factor (VEGF) is a major driver of blood vessel formation. However, the signal transduction pathways culminating in the biological consequences of VEGF signaling are only partially understood. Here, we show that the Hippo pathway effectors YAP and TAZ work as crucial signal transducers to me...	[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
2717441	Eu patient- centric clinical trial platform	EU-PEARL has the ambition of transforming the current approach of conducting single-compound clinical trials into the use of cross-company Integrated Research Platforms (IRPs), taking into consideration both patients’ interests and the opportunities from novel molecules for addressing medical needs. Patient-centric dat...	[ "Prevention, Diagnosis and Treatment of Human Diseases", "Computer Science and Informatics", "Institutions, Governance and Legal Systems" ]
644574	Encountering diplomacy in early modern southeast asia	This research project is a study in global history. It explores how diplomatic practices and foreign relations were shaped in the pluralistic, multi-centric, open geography of maritime Southeast Asia during the seventeenth and eighteenth century. In this period, exchange between local polities and aspiring European col...	[ "The Study of the Human Past", "Institutions, Governance and Legal Systems" ]
W153135129	The Use of Cortical Heterologous Sheets for Sinus Lift Bone Grafting: A Modification of Tulasne's Technique with 7-Year Follow-up	In this article, the authors describe their experience with using cortical deantigenated equine bone sheets in sinus lift grafting procedures performed on 23 patients. The technique employed resembles that described by Tulasne but avoids the need for using harvested calvaria bone and introduces some additional operatin...	[ "Materials Engineering", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1109/ICSE.2009.5070527	Learning Operational Requirements From Goal Models	Goal-oriented methods have increasingly been recognised as an effective means for eliciting, elaborating, analysing and specifying software requirements. A key activity in these approaches is the elaboration of a correct and complete set of opertional requirements, in the form of pre- and trigger-conditions, that guara...	[ "Computer Science and Informatics" ]
10.1051/0004-6361/201424326	Asteroseismic Inference On The Spin Orbit Misalignment And Stellar Parameters Of Hat P 7	Context. The measurement of obliquities ‐ the angle between the orbital and stellar rotation ‐ in star-planet systems is of great importance for understanding planet system formation and evolution. The bright and well-studied HAT-P-7 (Kepler-2) system is intriguing because several Rossiter-McLaughlin (RM) measurements ...	[ "Universe Sciences" ]
W1976557440	Metabonomic analysis of the toxic effects of TM208 in rat urine by HPLC-ESI-IT-TOF/MS	4-Methylpiperazine-1-carbodithiocacid-3-cyano-3,3-diphenylpropyl ester hydrochloride (TM208) was a potential antitumor new drug with many preliminary studies in pharmacokinetics and pharmacodynamics. This study aims to determine whether TM208 elicits toxic effects by metabonomics for the first time. Sprague Dawley (SD)...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1038/ncomms3023	Suppression of electron-vibron coupling in graphene nanoribbons contacted via a single atom	Graphene nanostructures, where quantum confinement opens an energy gap in the band structure, hold promise for future electronic devices. To realize the full potential of these materials, atomic-scale control over the contacts to graphene and the graphene nanostructure forming the active part of the device is required....	[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.1167/17.1.14	Transsaccadic Perceptual Fusion	Transsaccadic perceptual fusion is the integration of pre- and postsaccadic images into a single percept aligned in spatial coordinates. Several early studies reported an absence of transsaccadic fusion between dissimilar patterns, effectively stopping research on this question for three decades. We have now corrected ...	[ "Neuroscience and Disorders of the Nervous System" ]
Q4255875	APOYO A LA LIQUIDEZ PARA LAS MICROEMPRESAS AFECTADAS POR LA EMERGENCIA DE LA COVID	APOYO A LA LIQUIDEZ DE LAS MICROEMPRESAS Y LAS PEQUEÑAS EMPRESAS DE LOS SECTORES MINORISTA, DE SUMINISTRO Y DE SERVICIOS PERSONALES CUYA ACTIVIDAD HA SIDO SUSPENDIDA COMO CONSECUENCIA DEL DECRETO DEL PRIMER MINISTRO DE 11 DE MARZO DE 2020	[ "Individuals, Markets and Organisations", "Institutions, Governance and Legal Systems" ]
10.1038/NCLIMATE1595	Impact Of Climate Change On The Baltic Sea Ecosystem Over The Past 1 000 Years	Marked ecosystem changes in the Baltic Sea have been recorded in the sediments, but the reasons are not fully understood. Now an integrated study of high-resolution sediment records (of the past 1,000 years) in combination with an ecosystem modelling approach reveals that surface temperature changes strongly influence ...	[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
260820	Drug addiction: molecular changes in reward and aversion circuits	Our affective and motivational state is important for our decisions, actions and quality of life. Many pathological conditions affect this state. For example, addictive drugs are hyperactivating the reward system and trigger a strong motivation for continued drug intake, whereas many somatic and psychiatric diseases le...	[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1142/s0218271818420051	Neutron star mergers as sites of r-process nucleosynthesis and short gamma-ray bursts	Neutron star mergers have been long considered as promising sites of heavy [Formula: see text]-process nucleosynthesis. We overview the observational evidence supporting this scenario including: the total amount of [Formula: see text]-process elements in the galaxy, extreme metal-poor stars, geological radioactive elem...	[ "Universe Sciences", "Fundamental Constituents of Matter" ]
W2069651718	The Influence of the Heme Sixth Ligand on the Backbone Dynamics of an Endogenously Hexacoordinate Hemoglobin	The hemoglobin of the cyanobacterium Synechococcus sp. PCC 7002 (GlbN) protects the cell from reactive oxygen/nitrogen species.1 GlbN coordinates the heme group with two histidines in the absence of an exogenous ligand and undergoes an unusual post-translational attachment of the heme group to the H helix. GlbN is well...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences" ]
10.1093/imrn/rnv018	Simultaneous dense and nondense orbits and the space of lattices	We show that the set of points nondense under the ×n-map on the circle and dense for the geodesic flow after we identify the circle with a periodic horospherical orbit of the modular surface has full Haudorff dimension. We also show the analogous result for toral automorphisms on the 2-torus and a diagonal flow. Our re...	[ "Mathematics" ]
10.1111/brv.12110	Moving forward on facilitation research: response to changing environments and effects on the diversity, functioning and evolution of plant communities	Once seen as anomalous, facilitative interactions among plants and their importance for community structure and functioning are now widely recognized. The growing body of modelling, descriptive and experimental studies on facilitation covers a wide variety of terrestrial and aquatic systems throughout the globe. Howeve...	[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.1007/978-3-319-69904-2_26	Conceptual Modeling For Genomics Building An Integrated Repository Of Open Data	Many repositories of open data for genomics, collected by world-wide consortia, are important enablers of biological research; moreover, all experimental datasets leading to publications in genomics must be deposited to public repositories and made available to the research community. These datasets are typically used ...	[ "Integrative Biology: from Genes and Genomes to Systems", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Computer Science and Informatics" ]
US 0221518 W	87144, HUMAN AMINO ACID TRANSPORTER FAMILY MEMBER AND USES THEREFOR	The invention provides isolated nucleic acids molecules, designated 87144 nucleic acid molecules, which encode novel amino acid transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 87144 nucleic acid molecules, host cells into which the expr...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Products and Processes Engineering", "Prevention, Diagnosis and Treatment of Human Diseases" ]
W584526140	Quantum information science and its contributions to mathematics : American Mathematical Society Short Course, January 3-4, 2009, Washington, DC	This volume is based on lectures delivered at the 2009 AMS Short Course on Quantum Computation and Quantum Information, held January 3-4, 2009, in Washington, D.C. Part I of this volume consists of two papers giving introductory surveys of many of the important topics in the newly emerging field of quantum computation ...	[ "Mathematics", "Computer Science and Informatics" ]
978616	Exploring tribal representation across american indian-produced radio in us reservation and urban contexts	This comparative research into tribal radio representation identifies and analyses indigenous communication strategies in American Indian community radio to explore how community radio practices and structures can facilitate meaningful self-representation in contexts where indigenous groups are marginalised. Through th...	[ "The Social World and Its Interactions", "Studies of Cultures and Arts", "Systems and Communication Engineering" ]
US 2023/0035972 W	DYNAMIC PACKET RE-ORDERING, DISCARDING, AND FLOW SWITCHING	A radio access network node transmits a packet discard indication to configure a user equipment with indications that the node may discard packets corresponding to an indicated flow or corresponding to a flow received via an indicated resource. The packet discard indication configures the user equipment not to send a n...	[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
759655	Supercapacitive Polymer Electrodes for Directing Epithelial Repair	In this project we develop a new approach, using the conducting polymer poly (3,4-ethylene dioxythiophene) (PEDOT) to apply electrical fields (EFs) for guidance of cells. EFs are recognised as important guidance cues in the development and life cycle of human tissues. However, better tools are urgently needed to suppor...	[ "Cell Biology, Development, Stem Cells and Regeneration", "Prevention, Diagnosis and Treatment of Human Diseases", "Materials Engineering" ]
10.1103/PhysRevB.94.245422	Interpenetrating graphene networks: Three-dimensional node-line semimetals with massive negative linear compressibilities	We investigated the stability and mechanical and electronic properties of 15 metastable mixed sp2-sp3 carbon allotropes in the family of interpenetrating graphene networks (IGNs) using density functional theory (DFT). IGN allotropes exhibit nonmonotonic bulk and linear compressibilities before their structures irrevers...	[ "Condensed Matter Physics", "Materials Engineering" ]
10.1017/s1358246118000115	Lady Parts: The Metaphysics of Pregnancy	What is the metaphysical relationship between the fetus/embryo and the pregnant organism? In this paper I apply a substance metaphysics view developed by Barry Smith and Berit Brogaard to argue, on the basis of topological connectedness, that fetuses/embryos are Lady-Parts: part of the maternal organism up until birth....	[ "Texts and Concepts" ]
10.1016/j.jaac.2019.03.006	A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment	Objective: Women exposed to childhood maltreatment (CM) are more likely to exhibit insensitive parenting, which may have consequences for their offspring's development. Variation in the oxytocin-receptor gene (OXTR) moderates risk of CM-associated long-term sequelae associated with mother−child attachment, although fun...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1002/art.33411	Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: Relevance for recent optic nerve ischemia	Objective To assess local expression and plasma levels of pentraxin 3 (PTX3) in patients with giant cell arteritis (GCA). Methods Plasma and serum samples were obtained from 75 patients with GCA (20 of whom had experienced optic nerve ischemia in the previous 3 weeks and 24 of whom had experienced symptom onset in the ...	[ "Physiology in Health, Disease and Ageing", "Immunity, Infection and Immunotherapy" ]
10.1152/jn.00536.2013	Activation properties of trigeminal motoneurons in participants with and without bruxism	In animals, sodium- and calcium-mediated persistent inward currents (PICs), which produce long-lasting periods of depolarization under conditions of low synaptic drive, can be activated in trigeminal motoneurons following the application of the monoamine serotonin. Here we examined if PICs are activated in human trigem...	[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing" ]
10.1093/molbev/msw214	Transmission between archaic and modern human ancestors during the evolution of the oncogenic human papillomavirus 16	Every human suffers through life a number of papillomaviruses (PVs) infections, most of them asymptomatic. A notable exception are persistent infections by Human papillomavirus 16 (HPV16), the most oncogenic infectious agent for humans and responsible for most infection-driven anogenital cancers. Oncogenic potential is...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Immunity, Infection and Immunotherapy" ]
W2073045545	CPU/GPU computing for a multi-block structured grid based high-order flow solver on a large heterogeneous system	The high-order schemes have attracted more and more attention in computational fluid dynamics (CFD) simulations. As a kind of high-order schemes, weighted compact nonlinear schemes (WCNSs) have been widely applied in large eddy simulations, direct numerical simulations etc. However, due to the computational complexity,...	[ "Computer Science and Informatics", "Products and Processes Engineering" ]
10.1002/2017WR021726	Pore Scale Hydrodynamics In A Progressively Bioclogged Three Dimensional Porous Medium 3 D Particle Tracking Experiments And Stochastic Transport Modeling	Biofilms are ubiquitous bacterial communities that grow in various porous media including soils, trickling, and sand filters. In these environments, they play a central role in services ranging from degradation of pollutants to water purification. Biofilms dynamically change the pore structure of the medium through sel...	[ "Earth System Science", "Physical and Analytical Chemical Sciences", "Products and Processes Engineering" ]
10.1002/zaac.201300489	Synthesis and characterization of an azobenzene-functionalized ethene-bridged PMO	The azobenzene-functionalized ethene-bridged periodic mesoporous organosilica (PMO) was synthesized in a three step process. After synthesizing the pure PMO the azobenzene switch was post synthetically grafted at the ethene bridge. The successful synthesis was verified by N2 sorption measurements, IR spectroscopy, elem...	[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1146/annurev-cellbio-100818-125204	Developmental Cell Death in the Cerebral Cortex	In spite of the high metabolic cost of cellular production, the brain contains only a fraction of the neurons generated during embryonic development. In the rodent cerebral cortex, a first wave of programmed cell death surges at embryonic stages and affects primarily progenitor cells. A second, larger wave unfolds duri...	[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
CA 2013050773 W	UNITIZED PRECAST GRILLAGE FOUNDATION AND METHOD FOR MANUFACTURING THE SAME	The present invention discloses a unitized precast grillage foundation for supporting a tower comprising: a plurality of anchoring elements defining a grid for resting on an underlying surface; a base connected on the grid, the base comprising at least a first footing and a second footing spaced apart and at least one ...	[ "Products and Processes Engineering", "Materials Engineering" ]
10.1609/aaai.v34i05.6402	SensEmBERT: Context-Enhanced Sense Embeddings for Multilingual Word Sense Disambiguation	Contextual representations of words derived by neural language models have proven to effectively encode the subtle distinctions that might occur between different meanings of the same word. However, these representations are not tied to a semantic network, hence they leave the word meanings implicit and thereby neglect...	[ "Computer Science and Informatics" ]
10.1007/978-3-642-32512-0_6	What S The Frequency Kenneth Sublinear Fourier Sampling Off The Grid	We design a sublinear Fourier sampling algorithm for a case of sparse off-grid frequency recovery. These are signals with the form $$f(t) = \sum _{j=1}^k a_j \mathrm{e}^{i\omega _j t} + \int \nu (\omega )\mathrm{e}^{i\omega t}d\mu (\omega )$$f(t)=?j=1kajei?jt+??(?)ei?tdμ(? ); i. e. , exponential polynomials with a nois...	[ "Mathematics", "Computer Science and Informatics", "Systems and Communication Engineering" ]
320594	Tensor Decomposition for Data Analysis with Applications to Health and Environment	Multi-Way factor Analysis (MWA) is attracting growing interest in many disciplines of engineering, as described in this proposal. Because the applications are much more numerous than those that serve as focus for this project, the tools developed in the framework of the project will have major impact. MWA is probably t...	[ "Mathematics", "Computer Science and Informatics", "Products and Processes Engineering", "Environmental Biology, Ecology and Evolution" ]
3742484	Origin and maintenance of biodiversity: an ecological, evolutionary and developmental theory of organisms’ interactions	Ecological interactions are the backbone of ecosystems and play an essential role in the availability of the services they provide. These interactions are to a large extent dictated by the body size of the interacting organisms. Efforts to understand the origin and maintenance of networks of interacting organisms have ...	[ "Environmental Biology, Ecology and Evolution", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1016/j.actamat.2020.10.050	In-situ synchrotron X-ray micro-diffraction investigation of ultra-low-strain deformation microstructure in laminated Ti-Al composites	An ultra-low-strain deformation microstructure was revealed for the first time non-destructively in the bulk interior of an annealed laminated Ti-Al composite—in the “fully recrystallized” Al layer—by a synchrotron-based micro-diffraction technique, namely differential aperture X-ray microscopy (DAXM), through real spa...	[ "Condensed Matter Physics", "Materials Engineering" ]
978863	Ultra-Lightweight concrete for 3d printing technologies	The construction industry does not follow the same enlightened path as other fields of science and has thus suffered a technology bypass, relying on centuries-old processes and procedures to manage complex modern projects. In conventional concrete construction projects, more than 60% of the total cost is spent on the f...	[ "Products and Processes Engineering", "Materials Engineering" ]
10.1016/j.coi.2014.07.002	The dissection of complex susceptibility to infectious disease: Bacterial, viral and parasitic infections	Infectious diseases are the result of the exposure of susceptible hosts to pathogenic microbes. Genetic factors are important determinants of host susceptibility and efforts are being made to establish the molecular identity of such genetic susceptibility variants by genome-wide association studies. Results obtained to...	[ "Immunity, Infection and Immunotherapy", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1039/C6CC07773K	Ruthenium Ii Catalyzed C H Functionalizations On Benzoic Acids With Aryl Alkenyl And Alkynyl Halides By Weak O Coordination	C–H arylations of weakly coordinating benzoic acids were achieved by versatile ruthenium(II) catalysis with ample substrate scope. Thus, user-friendly ruthenium(II) biscarboxylate complexes modified with tricyclohexylphosphine enabled C–H functionalizations with aryl electrophiles. The unique versatility of the rutheni...	[ "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences" ]
984841	Punishment as communication: transgressors’ interpretation and understanding of punishment	Punishment is ubiquitous. We discipline children when they misbehave, and we demand even harsher sanctions for criminal offences. Punishment is thought to serve a communicative purpose: Through punishment, victims and third parties seek to send various “messages” to transgressors (e.g., condemning the wrongness of the ...	[ "The Social World and Its Interactions", "Institutions, Governance and Legal Systems", "The Human Mind and Its Complexity" ]
10.1002/anie.201607825	Vesicles in Nature and the Laboratory: Elucidation of Their Biological Properties and Synthesis of Increasingly Complex Synthetic Vesicles	The important role of vesicles in many aspects of cell function is well-recognized, but only recently have sophisticated imaging techniques begun to reveal their ubiquity in nature. While we further our understanding of the biological properties of vesicles and their physiological functions, increasingly elegant artifi...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Synthetic Chemistry and Materials", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1042/BJ20130241	In Vivo Characterization Of The Properties Of Sumo1 Specific Monobodies	Monobodies are small recombinant proteins designed to bind with high affinity to target proteins. Monobodies have been generated to mimic the SIM [SUMO (small ubiquitin-like modifier)-interacting motif] present in many SUMO target proteins, but their properties have not been determined in cells. In the present study we...	[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1039/c5mb00763a	Signalling to the nucleus under the control of light and small molecules	One major regulatory mechanism in cell signalling is the spatio-temporal control of the localization of signalling molecules. We synthetically designed an entire cell signalling pathway, which allows controlling the transport of signalling molecules from the plasma membrane to the nucleus, by using light and small mole...	[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1371/journal.ppat.1000883	Quorum sensing inhibition selects for virulence and cooperation in pseudomonas aeruginosa	With the rising development of bacterial resistance the search for new medical treatments beyond conventional antimicrobials has become a key aim of public health research. Possible innovative strategies include the inhibition of bacterial virulence. However, consideration must be given to the evolutionary and environm...	[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
interreg_3888	VIA ALPINA DEVELOPMENT VENTURE - Together with local stakeholders, develop high-quality natural and cultural tourism and education offers basing on the Via Alpina network of hiking trails	VIADVENTURE is based on the results of the VIA ALPINA project, developed within Interreg IIIB Alpine Space from 2001 to 2004. This project has established the Via Alpina "product", a network of hiking trails throughout the Alps, complete with basic information documents, an on-line database and specific marking and inf...	[ "Human Mobility, Environment, and Space", "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.1111/pbi.12416	Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants	Although plant biotechnology has been widely investigated for the production of clinical-grade monoclonal antibodies, no antibody products derived from transgenic plants have yet been approved by pharmaceutical regulators for clinical testing. In the Pharma-Planta project, the HIV-neutralizing human monoclonal antibody...	[ "Prevention, Diagnosis and Treatment of Human Diseases", "Biotechnology and Biosystems Engineering" ]
10.1016/j.redox.2020.101618	The passage from bone marrow niche to bloodstream triggers the metabolic impairment in Fanconi Anemia mononuclear cells	Fanconi Anemia (FA) is a disease characterized by bone marrow (BM) failure and aplastic anemia. In addition to a defective DNA repair system, other mechanisms are involved in its pathogenesis, such as defective mitochondrial metabolism, accumulation of lipids, and increment of oxidative stress production. To better und...	[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing" ]
10.1016/j.wace.2020.100262	Factors affecting extreme rainfall events in the South Pacific	Extreme rainfall events in the South Pacific are widespread and affected by various factors on different time scales. We use daily rainfall data from 20 stations over the South Pacific to investigate the characteristics of extreme rainfall events from 1979 to 2018. For regional analysis, we group the stations into thre...	[ "Earth System Science" ]
10.1016/j.euroecorev.2017.06.001	The importance of peers for compliance with norms of fair sharing	A burgeoning literature in economics has started examining the role of social norms in explaining economic behavior. Surprisingly, the vast majority of this literature has studied social norms in asocial decision settings, where individuals are observed to act in isolation from each other. In this paper we use a large-...	[ "Individuals, Markets and Organisations", "The Social World and Its Interactions" ]
10.3390/ijms20020373	Expanding the Genetic Code for Site-Directed Spin-Labeling	Site-directed spin labeling (SDSL) in combination with electron paramagnetic resonance (EPR) spectroscopy enables studies of the structure, dynamics, and interactions of proteins in the noncrystalline state. The scope and analytical value of SDSL–EPR experiments crucially depends on the employed labeling strategy, with...	[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
172205	Bringing personalized knowledge to students in public schools through artificial intelligence in elearning	In the EU, private and public expenditure per full-time student rose from 5,674 to 6,900, i.e. by almost 22% from 2005 to 2010 whilst PISA results remain largely stable. In order to impact students’ learning curve, we need advanced learning tools, i.e. e-learning needs to be infused with AI: content creation tools, ada...	[ "Computer Science and Informatics", "The Social World and Its Interactions" ]
AT 0100151 W	CONCEALED WINDOW AND DOOR FRAME	The invention relates to a plastic, especially polyethylene, concealed frame, which can be directly set in concrete. The inventive frame comprises a base element (1) and a frame (3), said frame (3) being able to move to a certain extent in relation to the base element (1) before being definitively joined thereto (1) in...	[ "Products and Processes Engineering", "Materials Engineering" ]
10.1145/2187836.2187948	Opal Automated Form Understanding For The Deep Web	Forms are our gates to the web. They enable us to access the deep content of web sites. Automatic form understanding unlocks this content for applications ranging from crawlers to meta-search engines and is essential for improving usability and accessibility of the web. Form understanding has received surprisingly litt...	[ "Computer Science and Informatics" ]
IB 2009005383 W	SINGLE-LENS EXTENDED DEPTH-OF-FIELD IMAGING SYSTEMS	An extended depth of field (EDOF) imaging system (10) is disclosed that has a corresponding extended depth of focus (EDOF'). The imaging system has an optical system (20) consisting of a single lens element (22) and an objectwise aperture stop (AS) arrange substantially at a zero-coma axial position. The single lens el...	[ "Systems and Communication Engineering", "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
10.1016/j.ffa.2018.12.002	Irreducible polynomials over F<inf>2<sup>r</sup></inf> with three prescribed coefficients	For any positive integers n≥3 and r≥1, we prove that the number of monic irreducible polynomials of degree n over F2r in which the coefficients of Tn−1, Tn−2 and Tn−3 are prescribed has period 24 as a function of n, after a suitable normalization. A similar result holds over F5r, with the period being 60. We also show ...	[ "Mathematics" ]
10.1039/C7CC02997G	Supramolecular Functional Assemblies Dynamic Membrane Transporters And Peptide Nanotubular Composites	The fabrication of functional molecular devices constitutes one of the most important current challenges for chemical sciences. The complex processes accomplished by living systems continuously demand the assistance of non-covalent interactions between molecular building blocks. Additionally, these building blocks (pro...	[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1016/j.microc.2015.11.024	Virtual reading of a large ancient handwritten science book	We present a fundamental development step of a new technique to read and digitize ancient handwritten documents. Chemical analysis by x-ray fluorescence and x-ray tomography enabled us to decipher words and drawings from inside a closed, 200-pages 18. th century handwritten book. The ink chemistry is essential: tomogr...	[ "Physical and Analytical Chemical Sciences", "The Study of the Human Past", "Computer Science and Informatics" ]
2728245	Sharing-Economy matching platform to revolutionize last-mile logistics	The rapid growth in e-commerce is changing the consumer behavior, increasing the logistic burden in last-mile delivery. From this fact are arisen two mayor problems. For one side, our logistic infrastructure will never be ready for the number of delivery-vehicles required to fulfill such demand. From the other, last-mi...	[ "Products and Processes Engineering", "Computer Science and Informatics" ]
W2006148285	Optimized Multisite Ventricular Pacing in Postoperative Single-Ventricle Patients	Ventricular dyssynchrony is associated with morbidity and mortality after palliation of a single ventricle. The authors hypothesized that resynchronization with optimized temporary multisite pacing postoperatively would be safe, feasible, and effective. Pacing was assessed in the intensive care unit within the first 24...	[ "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.15184/aqy.2018.257	Scales, weights and weight-regulated artefacts in Middle and Late Bronze Age Britain	The identification of weights and weight-regulated artefacts is of primary importance for confirming the existence of European Bronze Age value ratios and exchange systems. Until recently, however, no such Bronze Age artefacts had been identified in Britain. Here, statistical analysis identifies - for the first time - ...	[ "The Study of the Human Past" ]
668640	The Enigma of the Hyksos	The Hyksos (Greek rendering of the Egyptian title “rulers of the foreign countries”) were a dynasty of foreign rulers of Egypt between c.1640 and 1530 BC. Some modern researchers, following the ancient historian Flavius Josephus (1st cent. AD) thought they were ancestors of the early Israelites, others suggested that t...	[ "The Study of the Human Past" ]
10.1016/j.vibspec.2012.07.011	Micro ATR FTIR imaging of hanging drop protein crystallisation	Protein crystallisation is of great importance within structural proteomic projects where considerable time and effort is spent trying to obtain high resolution structural information from the X-ray diffraction of protein crystals. The crystallisation process is largely empirical due to a lack of understanding of cryst...	[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1088/1742-6596/1065/21/212026	Combining Experiments For Linear Dynamic Network Identification In The Presence Of Nonlinearities	In many practical applications it might be desirable to excite only point at a time in an interconnection of multiple dynamic subsystems (e. g. large-scale system). Therefore multiple experiments need to be combined to successfully identify one or more subsystems in the network of subsystems. This papers illustrates h...	[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1109/TCOMM.2015.2456177	Reduced-Complexity Soft-Decision Multiple-Symbol Differential Sphere Detection	Unlike a generic PSK/QAM detector, which may visit a constellation diagram only once, a depth-first Sphere Decoder (SD) has to re-visit the same constellation diagram multiple times. Therefore, in order to prevent the SD from repeating the detection operations, the Schnorr-Euchner search strategy of Schnorr and Euchner...	[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.15252/embj.201593534	Parental epigenetic asymmetry of PRC2-mediated histone modifications in the Arabidopsis endosperm	Parental genomes in the endosperm are marked by differential DNA methylation and are therefore epigenetically distinct. This epigenetic asymmetry is established in the gametes and maintained after fertilization by unknown mechanisms. In this manuscript, we have addressed the key question whether parentally inherited di...	[ "Integrative Biology: from Genes and Genomes to Systems", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W2323913645	Relative Valuation	In this paper we studied the sectoral behavior of Indian capital market through relative valuation for a period over a period of 21 years. The period covered under the study is from 1990–2010. The study has been done both for a total period (1990–2010) and three sub-periods, viz. 1990–96, 1997–2003, 2004–10. The resear...	[ "Individuals, Markets and Organisations" ]
US 21159780 A	Glass ribbon float tank with a pyrometer assembly having a heated viewing tube and method of use	A viewing tube extension for an infrared radiation pyrometer includes a tube having a heater therein. The heater has a passageway so that the pyrometer sights a glass ribbon moving through a forming chamber of a flat glass making apparatus. Vapors from the heating chamber moving into the tube are maintained above their...	[ "Materials Engineering", "Products and Processes Engineering" ]
US 2015/0024664 W	USE OF MICROPARTICLE ADDITIVES TO SIMULTANEOUSLY ENABLE ARTIFACT-FREE IMAGE REGISTRATION, AUTO-FOCUSING, AND CHROMATIC ABERRATION CORRECTION IN MICROSCOPY	High-contrast, high-density cell-sized microparticles (120) are introduced into a cell (llO)-containing solution prior to the solution being spread onto a planar substrate (100) for imaging. The microparticles facilitate both the process of imager autofocusing and the subsequent registration of multiple images taken of...	[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
10.1111/1365-2745.12504	Evidence For Arrested Succession In A Liana Infested Amazonian Forest	1. Empirical evidence and modelling both suggest that global changes may lead to an increased dominance of lianas and thus to an increased prevalence of liana-infested forest formations in tropical forests. The implications for tropical forest structure and the carbon cycle remain poorly understood. 2. We studied the e...	[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
EP 2006010357 W	IMPROVED METHOD FOR PRODUCING WASHING OR CLEANING AGENTS	The invention relates to a method for producing washing or cleaning agent granulates, adapted to produce, at low pressure and with high throughput rates, granulates that have a narrow particle distribution. According to said method, a slurry comprising washing or cleaning-active ingredients is atomized through a hollow...	[ "Products and Processes Engineering", "Materials Engineering" ]
10.7717/peerj.5944	Differences in persistence between dogs and wolves in an unsolvable task in the absence of humans	Despite being closely related, dogs perform worse than wolves in independent problem-solving tasks. These differences in problem-solving performance have been attributed to dogs’ greater reliance on humans, who are usually present when problem-solving tasks are presented. However, more fundamental motivational factors ...	[ "Environmental Biology, Ecology and Evolution", "The Human Mind and Its Complexity" ]
10.1242/jcs.115808	The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish	The Na+/K+-ATPase generates ion gradients across the plasma membrane, essential for multiple cellular functions. In mammals, four different Na+/K+-ATPase α-subunit isoforms are associated with characteristic cell-type expression profiles and kinetics. We found the zebrafish α2Na+/K+-ATPase associated with striated musc...	[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W1974708874	Tryptophan-scanning mutagenesis of the ligand binding pocket in Thermotoga maritima arginine-binding protein	The Thermotoga maritima arginine binding protein (TmArgBP) is a member of the periplasmic binding protein superfamily. As a highly thermostable protein, TmArgBP has been investigated for the potential to serve as a protein scaffold for the development of fluorescent protein biosensors. To establish a relationship betwe...	[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1007/s10892-017-9246-0	This is a Tricky Situation: Situationism and Reasons-Responsiveness	Situations are powerful: the evidence from experimental social psychology suggests that agents are hugely influenced by the situations they find themselves in, often without their knowing it (this, roughly-speaking, is the thesis of situationism). In our paper, we evaluate how situational factors affect our reasons-res...	[ "Texts and Concepts", "The Human Mind and Its Complexity" ]
10.1371/journal.pone.0194179	Niosomes, an alternative for liposomal delivery	Niosomes are used in studies for drug delivery or gene transfer. However, their physical properties and features relative to liposomes are not well documented. To characterize and more rationally optimize niosome formulations, the properties of these vesicle systems are compared to those of liposomes composed of phosph...	[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials", "Materials Engineering" ]
W2009148965	Theory of the spin Hall effect, and its inverse, in a ferromagnetic metal near the Curie temperature	We give a theory of the inverse spin Hall effect (ISHE) in ferromagnetic metals based on skew scattering via collective spin fluctuations. This extends Kondo's theory of the anomalous Hall effect (AHE) to include short-range spin-spin correlations. We find a relation between the ISHE and the four-spin correlations near...	[ "Condensed Matter Physics" ]
743077	Thermal Magnetic Resonance: A New Instrument to Define the Role of Temperature in Biological Systems and Disease for Diagnosis and Therapy	Temperature is a physical parameter with diverse biological implications and crucial clinical relevance. With an ever increasing interest in thermal applications, non-invasive in vivo methods to modulate temperature and characterize subsequent effects are imperative. Magnetic resonance (MR) is a mainstay of diagnosis b...	[ "Prevention, Diagnosis and Treatment of Human Diseases", "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1002/adfm.201103034	Co-implantation of carbon and protons: An integrated silicon device technology compatible method to generate the lasing G-center	The optically active carbon related G-center is attracting great interest because of evidence that it can provide lasing in silicon. Here a technique to form the G-center in silicon is reported. The carbon G-center is generated by implantation of carbon followed by proton irradiation. Photoluminescence measurements con...	[ "Condensed Matter Physics", "Materials Engineering", "Synthetic Chemistry and Materials" ]
883476	Early childhood education elearning framework, leveraging novel technology for a whole new way of learning music.	Scientific research proves that early music education, specifically by children ages 0 to 5, is a powerful tool for attaining children’s full intellectual, social and creative potential. Numerous research studies show indisputable evidence that learning music at an early age speeds the development of speech and reading...	[ "Computer Science and Informatics", "The Social World and Its Interactions" ]
10.1051/0004-6361/200913483	The Agn Fraction Of Submm Selected Galaxies And Contributions To The Submm Mm Wave Extragalactic Background Light	We present a comparison of the SCUBA Half Degree Extragalactic Survey (SHADES) at 450, 850 and 1100 microns with deep guaranteed time 15 microns AKARI FU-HYU survey data and Spitzer guaranteed time data at 3. 6-24 microns in the Lockman Hole East. The AKARI data was analysed using bespoke software based in part on the ...	[ "Universe Sciences" ]
948601	STOrylines of futuRe extreMes	Future climate projections show a strengthening of the hydrological cycle with more droughts and floods expected. This means a higher likelihood of cascading drought-to-flood disasters such as the Millennium Drought – Brisbane flooding in Australia or the California drought – Oroville spillway collapse in the US. Curre...	[ "Earth System Science", "Human Mobility, Environment, and Space" ]
713780	Photonic Terahertz Signal Analyzers	Spectrum analysis and vector network analysis are enabling technologies for component development throughout the microwave and millimeter wave band. Due to the lack of affordable electronics for frequencies above 100 GHz, vector network analyzers (VNAs) have to use frequency extenders to reach into the THz frequency ba...	[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
223412	Advanced integrated supervisory and wind turbine control for optimal operation of large wind power plants	Cost of energy (COE) is the most important single factor in deployment of renewables in the energy system. Reduction of COE is, among other things, directly related to operational control of Wind Power Plants (WPP) as a whole and the individual wind turbines (WT) within them. In the Total Control project the COE reduct...	[ "Products and Processes Engineering", "Systems and Communication Engineering" ]
2718632	Vegetable ozone therapy crops sanitized naturally from seed to feed	Crop pests and disease have serious consequences for agriculture, in terms of economic losses and wastefulness of resources. In addition, according to the FAO, transboundary plant pests and diseases – growing in the last years because of globalization, trade and climate change, as well as reduced resilience in producti...	[ "Products and Processes Engineering", "Biotechnology and Biosystems Engineering", "Environmental Biology, Ecology and Evolution" ]
170934	Learning from failure in a collaborative entrepreneurship network	The LIFE project is about collaborative learning from failure in entrepreneurship and collaborative actions to bring entrepreneurship forward. Although cultural diversity is one of Europe’s biggest assets, this also creates severe obstacles for entrepreneurs to scale their efforts at the pan-European level. The distri...	[ "The Social World and Its Interactions", "Individuals, Markets and Organisations" ]
10.1073/pnas.1220345110	Rotavirus mRNAS are released by transcript-specific channels in the double-layered viral capsid	Rotaviruses are the single most common cause of fatal and severe childhood diarrheal illness worldwide (>125 million cases annually). Rotavirus shares structural and functional features with many viruses, such as the presence of segmented double-stranded RNA genomes selectively and tightly packed with a conserved numbe...	[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Immunity, Infection and Immunotherapy" ]
W28828025	Adult house mouse (Mus musculus) ultrasonic calls: hormonal and pheromonal regulation	Abstract An adult male house mouse typically begins calling at ultrasonic frequencies when presented with either a female mouse or her odors. Although direct experimental evidence has been difficult to obtain, ethological, genetic, endocrine, neurological, sound-spectrographic and perceptual findings all indirectly sup...	[ "Physiology in Health, Disease and Ageing", "Neuroscience and Disorders of the Nervous System", "Environmental Biology, Ecology and Evolution" ]
10.1002/pssb.201200155	Effect of gap modes on graphene and multilayer graphene in tip-enhanced Raman spectroscopy	The experimental system formed by an electrochemically etched Au tip and an Au substrate is studied in a tip-enhanced Raman spectroscopy (TERS) setup with side illumination. A resonant optical cavity is created allowing the interaction between localized surface plasmons (LSPs) from the tip and surface plasmon polariton...	[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.1073/pnas.1616392114	Ancient X chromosomes reveal contrasting sex bias in Neolithic and Bronze Age Eurasian migrations	Dramatic events in human prehistory, such as the spread of agriculture to Europe from Anatolia and the late Neolithic/Bronze Age migration from the Pontic-Caspian Steppe, can be investigated using patterns of genetic variation among the people who lived in those times. In particular, studies of differing female and mal...	[ "The Study of the Human Past", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1016/j.jet.2014.09.002	Liquid bundles	Parties in financial markets, industries, compensation design or politics may negotiate on either a piecemeal or a bundled basis. Little is known about the desirability of bundling when values are common and/or information endogenous. The paper shows that bundling encourages information-equalizing investments, thereby ...	[ "Individuals, Markets and Organisations" ]
10.1136/gutjnl-2018-317065	Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets	ObjectiveHepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent. DesignHere, we combined an RNAi loss-of-function and small molecule...	[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1038/leu.2017.137	MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation	Acute Graft-versus-host disease (GVHD) is a major immunological complication after allogeneic hematopoietic cell transplantation and a better understanding of the molecular regulation of the disease could help to develop novel targeted therapies. Here we found that a G/C polymorphism within the human microRNA-146a (miR...	[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1016/j.epsl.2012.09.051	Gas emissions due to magma-sediment interactions during flood magmatism at the Siberian Traps: Gas dispersion and environmental consequences	We estimate the fluxes of extremely reduced gas emissions produced during the emplacement of the Siberian Traps large igneous province, due to magma intrusion in the coaliferous sediments of the Tunguska Basin. Using the results of a companion paper (Iacono-Marziano et al. , accepted for publication), and a recent work...	[ "Earth System Science", "Physical and Analytical Chemical Sciences" ]
225379	Rethinking the health experience and active lifestyles of chinese students	Rethinking the Health Experience and Active Lifestyles of Chinese Students Rising immigration rates into the European Union (EU) has brought increased cultural and linguistic diversity, but also increasing levels of inequalities and the associated challenges of their alleviation. The promotion of physical activity as p...	[ "The Social World and Its Interactions", "Human Mobility, Environment, and Space", "Prevention, Diagnosis and Treatment of Human Diseases" ]

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