id stringlengths 6 42 | title stringlengths 3 499 | abstract stringlengths 0 6.24k | label listlengths 0 6 |
|---|---|---|---|
10.1038/ncomms3848 | A quantitative telomeric chromatin isolation protocol identifies different telomeric states | Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified and analysed by mass spectrometry. QTIP involves stable isotope... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Physiology in Health, Disease and Ageing"
] |
10.1021/bm401720z | Insights into the coassembly of hydrogelators and surfactants based on aromatic peptide amphiphiles | The coassembly of small molecules is a useful means of increasing the complexity and functionality of their resultant supramolecular constructs in a modular fashion. In this study, we explore the assembly and coassembly of serine surfactants and tyrosine-leucine hydrogelators, capped at the N-termini with either fluore... | [
"Physical and Analytical Chemical Sciences",
"Materials Engineering"
] |
10.3390/molecules18055611 | Chitosan for gene delivery and orthopedic tissue engineering applications | Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown t... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Materials Engineering"
] |
3731107 | Normalization of multimodal brain networks for integral and predictive mapping of neurological disorders | Modern network science has introduced exciting new opportunities for understanding the brain as a complex system of interacting units in both health and disease and across the human lifespan. Despite the rapidly growing interdisciplinary science of complex networks, which spans the range from genetic and metabolic netw... | [
"Neuroscience and Disorders of the Nervous System",
"Computer Science and Informatics"
] |
W803108629 | Multi-Level Search Space Reduction Framework for Face Image Database | In face recognition, searching and retrieval of relevant images from a large database form a major task. Recognition time is greatly related to the dimensionality of the original data and the number of training samples. This demands the selection of discriminant features that produce similar results as the entire set a... | [
"Computer Science and Informatics"
] |
10.1007/978-3-030-04224-0_41 | Linear periodic discriminant analysis of multidimensional signals | Extracting relevant information from noisy multidimensional signals has tremendous impacts in numerous applications, ranging from audio separation to electrophysiological recording analysis. Linear filters are often considered to reconstruct and interpret the latent sources generating the data. Known properties of the ... | [
"Neuroscience and Disorders of the Nervous System",
"Mathematics"
] |
10.1523/JNEUROSCI.1322-14.2014 | Regulation Of Axonal Midline Guidance By Prolyl 4 Hydroxylation In Caenorhabditis Elegans | Neuronal wiring during development requires that the growth cones of axons and dendrites are correctly guided to their appropriate targets. As in other animals, axon growth cones in Caenorhabditis elegans integrate information in their extracellular environment via interactions among transiently expressed cell surface ... | [
"Neuroscience and Disorders of the Nervous System",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
Q101445 | DESPUÉS DE UN HILO DE ŁOWICZ. APOYO A LA EXPORTACIÓN PARA LA INDUSTRIA TEXTIL | El objetivo principal del proyecto que se implementará para los años 2018-2019 es la promoción económica de la industria textil desde Łódő, teniendo en cuenta el papel de Łowicz mediante la creación de condiciones para la internacionalización de las actividades empresariales y la construcción de vínculos económicos. Ob... | [
"Individuals, Markets and Organisations",
"Human Mobility, Environment, and Space"
] |
10.1002/admt.201800328 | Aerosol-Jet Printed Fine-Featured Triboelectric Sensors for Motion Sensing | Triboelectric motion sensors, based on the generation of a voltage across two dissimilar materials sliding across each other as a result of the triboelectric effect, have generated interest due to the relative simplicity of the typical grated device structures and materials required. However, these sensors are often li... | [
"Materials Engineering",
"Condensed Matter Physics",
"Synthetic Chemistry and Materials"
] |
978714 | New heterogeneous catalyst materials for hydrogenation of co2 to formic acid: metallophthalocyanine-based 2d- and 3d covalent organic frameworks | In CO2COFs project we will meet the world’s need for new heterogeneous catalyst materials for catalytic CO2 hydrogenation to formic acid (FA) by developing novel metallophthalocyanine (MPc)-based covalent organic frameworks (COFs) with high crystallinity and large surface area for renewable hydrogen storage in formic a... | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1016/j.immuni.2018.12.010 | Human Fetal TNF-α-Cytokine-Producing CD4 <sup>+</sup> Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life | Although the fetal immune system is considered tolerogenic, preterm infants can suffer from severe intestinal inflammation, including necrotizing enterocolitis (NEC). Here, we demonstrate that human fetal intestines predominantly contain tumor necrosis factor-α (TNF-α) + CD4 + CD69 + T effector memory (Tem) cells. Sing... | [
"Immunity, Infection and Immunotherapy",
"Cell Biology, Development, Stem Cells and Regeneration",
"Physiology in Health, Disease and Ageing"
] |
10.1039/C6LC90022D | Artificial Micro Swimmers In Simulated Natural Environments | Microswimmers, such as bacteria, are known to show different behaviours depending on their local environment. They identify spatial chemical gradients to find nutrient rich areas (chemotaxis) and interact with shear flows to accumulate in high shear regions. Recently, artificial microswimmers have been developed which ... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
313626 | THE GENDER OF JUSTICE: THE PROSECUTION OF SEXUAL VIOLENCE IN ARMED CONFLICT | The international community now recognises the impact of ‘gender-based harms’ of conflict, the armed violence that targets or disproportionately affects women. It also acknowledges the obligation to prosecute these crimes. However, many claim that international justice continues to fail women victims of war. So are we ... | [
"The Social World and Its Interactions",
"Institutions, Governance and Legal Systems"
] |
2728201 | Functional keratin kerasol | Keratin as a key structural material has been used in cosmetics as a raw material in skin and hair care products in a generalized way since several years, marking a trend in all cosmetic manufacturers offering keratin treatment lines. The human body takes advantage of this cosmetic contribution of keratin through conta... | [
"Products and Processes Engineering",
"Materials Engineering",
"Synthetic Chemistry and Materials"
] |
10.1016/j.pt.2015.11.004 | Microbiota Control of Malaria Transmission | Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, s... | [
"Immunity, Infection and Immunotherapy",
"Physiology in Health, Disease and Ageing",
"Environmental Biology, Ecology and Evolution"
] |
10.1039/c5nr04906g | Unbinding forces and energies between a siRNA molecule and a dendrimer measured by force spectroscopy | Single molecule force spectroscopy has been applied to measure the unbinding forces and energies between a siRNA molecule and polyamidoamine dendrimers deposited on a mica surface. | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1007/978-1-4939-6881-7_6 | Plasma Membrane Sheets For Studies Of B Cell Antigen Internalization From Immune Synapses | Surrogate planar and membrane systems have been employed to study the architecture of immune synapses; however, they often do not recapitulate trans-synaptic extraction and endocytosis of ligands by the immune cells. Transendocytosis (or trogocytosis) of antigen from immune synapses is particularly critical for antigen... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1088/1367-2630/14/6/063024 | Tsirelson S Bound From A Generalized Data Processing Inequality | The strength of quantum correlations is bounded from above by Tsirelson's bound. We establish a connection between this bound and the fact that correlations between two systems cannot increase under local operations, a property known as the data processing inequality (DPI). More specifically, we consider arbitrary conv... | [
"Mathematics",
"Fundamental Constituents of Matter"
] |
10.1016/bs.mcb.2014.11.003 | Mapping forces and kinematics during collective cell migration | Fundamental biological processes including morphogenesis and tissue repair require cells to migrate collectively. In these processes, epithelial or endothelial cells move in a cooperative manner coupled by intercellular junctions. Ultimately, the movement of these multicellular systems occurs through the generation of ... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
US 201916533725 A | Connection and resistance training system | A wearable connection and resistance training system having a waist strap, and left and right upper leg straps and an attachment point device which serves as a connection piece configured to be held underneath a user's torso and between the user's legs to provide rotational resistance to improve and strengthen rotation... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
W2001570648 | The next controversy in genetic testing: clinical data as trade secrets? | Sole-source business models for genetic testing can create private databases containing information vital to interpreting the clinical significance of human genetic variations. But incomplete access to those databases threatens to impede the clinical interpretation of genomic medicine. National health systems and insur... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Integrative Biology: from Genes and Genomes to Systems",
"Institutions, Governance and Legal Systems"
] |
10.1002/adma.201700486 | Tuning Up or Down the Critical Thickness in LaAlO<inf>3</inf>/SrTiO<inf>3</inf> through In Situ Deposition of Metal Overlayers | The quasi 2D electron system (q2DES) that forms at the interface between LaAlO3 and SrTiO3 has attracted much attention from the oxide electronics community. One of its hallmark features is the existence of a critical LaAlO3 thickness of 4 unit-cells (uc) for interfacial conductivity to emerge. In this paper, the chemi... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
268782 | The Role of Arl Proteins in Retinal and other Ciliary Diseases | Arl (Arf-like) proteins, GTP-binding proteins of the Ras superfamily, are molecular switches that cycle between a GDP-bound inactive and GTP-bound active state. There are 16 members of the Arl subfamily in the human genome whose basic mechanistic function is unknown. The interactome of Arl2/3 includes proteins involved... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Physiology in Health, Disease and Ageing"
] |
W1601442301 | Characteristics of interfacial signatures on a wind-driven gravity-capillary wave | [1] Direct numerical simulation of a wind-driven gravity-capillary wave and the underlying turbulent flow is conducted to identify the characteristic signatures of various surface parameters, including temperature, gas flux, velocities, and roughness, and to reveal the impacts of the nonbreaking surface waves on these ... | [
"Earth System Science",
"Physical and Analytical Chemical Sciences"
] |
10.1021/jp400418w | Minor-groove binding drugs: Where is the second hoechst 33258 molecule? | Hoechst 33258 binds with high affinity into the minor groove of AT-rich sequences of double-helical DNA. Despite extensive studies of this and analogous DNA binding molecules, there still remains uncertainty concerning the interactions when multiple ligand molecules are accommodated within close distance. Albeit not of... | [
"Physical and Analytical Chemical Sciences",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
306990 | Material-driven Fibronectin Fibrillogenesis to Engineer Synergistic Growth Factor Microenvironments | Cells within tissues are surrounded by fibrillar extracellular matrices (ECM) that support cell adhesion, migration, proliferation and differentiation. Fibronectin (FN) is an ECM protein organized into fibrillar networks by cells through an integrin-mediated process. This assembly allows the unfolding of the molecule, ... | [
"Materials Engineering",
"Cell Biology, Development, Stem Cells and Regeneration",
"Biotechnology and Biosystems Engineering"
] |
219819 | Attodna: how electronic motions affect the photostability of the genomic material | AttoDNA considers the early (attosecond to few-femtosecond) events following photo-excitation/ionisation in DNA/RNA canonical and non-canonical nucleobases for the first time. This involves the electronic movement before the onset of nuclear dynamics, ascertaining the length in which this initial purely electronic moti... | [
"Physical and Analytical Chemical Sciences",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
617659 | The Great War and Modern Philosophy | The First World War was an unprecedented event of destruction, transformation, and renewal that left no aspect of European culture unchanged. Philosophy proved no exception: the war motivated an historically singular mobilization of philosophers to write about the war during the years of conflict; significant works of ... | [
"Texts and Concepts",
"The Study of the Human Past"
] |
881787 | Engineering bio-inspired systems for the conversion of solar energy to hydrogen | With this proposal, I aim to achieve the efficient conversion of solar energy to hydrogen. The overall objective is to engineer bio-inspired systems able to convert solar energy into a separation of charges and to construct devices by coupling these systems to catalysts in order to drive sustainable and effective water... | [
"Materials Engineering",
"Synthetic Chemistry and Materials",
"Physical and Analytical Chemical Sciences",
"Biotechnology and Biosystems Engineering"
] |
10.1088/1475-7516/2019/10/065 | General Relativistic Cosmological N Body Simulations Part I Time Integration | This is the first in a series of papers devoted to fully general-relativistic N-body simulations applied to late-time cosmology. The purpose of this paper is to present the combination of a numerical relativity scheme, discretization method and time-integration algorithm that provides satisfyingly stable evolution. Mor... | [
"Universe Sciences",
"Fundamental Constituents of Matter"
] |
US 2017/0048635 W | CORD LOCK | A cord lock includes various components used to slidably adjust a length of cord. The cord lock may include a first cord-clamp bar and a second cord-clamp bar that are movably coupled to each other, to allow control of frictional resistance on a cord threaded through various apertures and cord-receiving channels of the... | [
"Products and Processes Engineering"
] |
10.1039/C5CP03392F | Insights Into Colour Tuning Of Chlorophyll Optical Response In Green Plants | First-principles calculations within the framework of real-space time-dependent density functional theory have been performed for the complete chlorophyll (Chl) network of the light-harvesting complex from green plants, LHC-II. A local-dipole analysis method developed for this work has made possible the studies of the ... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
Q2692024 | Subvenção para o fundo de maneio do INDPROD Sławomir Adamczak | O projeto diz respeito ao apoio do empresário no fornecimento de liquidez financeira e ao apoio às atividades atuais devido às dificuldades financeiras sentidas pelo empresário em resultado do surto de COVID-19. Assistência financeira prestada ao abrigo do programa n.º SA.57015 (2020/N) | [
"Individuals, Markets and Organisations"
] |
10.18653/v1/s17-1012 | Distributed prediction of relations for entities: The easy, the difficult, and the impossible | Word embeddings are supposed to provide easy access to semantic relations such as "male of" (man-woman). While this claim has been investigated for concepts, little is known about the distributional behavior of relations of (Named) Entities. We describe two word embedding-based models that predict values for relational... | [
"Computer Science and Informatics"
] |
10.1016/j.sbi.2019.09.001 | Amyloid structures: much more than just a cross-β fold | In recent years our understanding of amyloid structure has been revolutionised by innovations in cryo-electron microscopy, electron diffraction and solid-state NMR. These techniques have yielded high-resolution structures of fibrils isolated from patients with neurodegenerative disease, as well as those formed from amy... | [
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1016/j.ejpb.2017.09.014 | Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson's disease related toxin 6-hydroxydopamine | Neurodegenerative diseases, as Parkinson's disease (PD), involve irreversible neural cell damage and impairment. In PD, there is a selective degeneration of the dopaminergic neurons leading to motor symptoms. A common finding in PD neurodegeneration is the increase of reactive oxygen species (ROS), leading to oxidative... | [
"Neuroscience and Disorders of the Nervous System",
"Cell Biology, Development, Stem Cells and Regeneration",
"Materials Engineering"
] |
10.1093/mnras/stv996 | A fast and explicit algorithm for simulating the dynamics of small dust grains with smoothed particle hydrodynamics | We describe a simple method for simulating the dynamics of small grains in a dusty gas, relevant to micron-sized grains in the interstellar medium and grains of centimetre size and smaller in protoplanetary discs. The method involves solving one extra diffusion equation for the dust fraction in addition to the usual eq... | [
"Universe Sciences",
"Computer Science and Informatics"
] |
10.1042/bcj20180748 | The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties | Selective autophagy has emerged as an important mechanism by which eukaryotic cells control the abundance of specific proteins. This mechanism relies on cargo recruitment to autophagosomes by receptors that bind to both the ubiquitin-like AUTOPHAGY8 (ATG8) protein through ATG8-interacting motifs (AIMs) and to the cargo... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Physical and Analytical Chemical Sciences"
] |
10.1109/ISIT.2015.7282410 | Cooperative Multiple Access Channels With Oblivious Encoders | In this paper we study the cooperative multiple access channel (MAC) with oblivious encoders and characterize its capacity region. Cooperation means that one encoder sends a message to the other encoder via a rate-limited link prior to transmission, while partial cribbing means that one encoder obtains a deterministic ... | [
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
220301 | Multi-Level model calibration for the assessment of historical masonry structures | The MultiCAMS project will develop an advanced computational strategy including numerical modelling and innovative model calibration for realistic assessment of historical unreinforced masonry structures. The presence of relevant historical heritage in Europe, partly still in use, together with high seismic risk in the... | [
"Products and Processes Engineering",
"Materials Engineering",
"Computer Science and Informatics"
] |
10.3389/fvets.2020.00183 | Comparison of Behavior and Genetic Structure in Populations of Family and Kenneled Beagles | In dogs, the social and spatial restriction associated with living in a kennel environment could lead to chronic stress and the development of abnormal behaviors (“kennel-dog syndrome”). However, little is known about how kenneled dogs differ from their conspecifics living as pets in human families. In the current stud... | [
"Environmental Biology, Ecology and Evolution",
"Integrative Biology: from Genes and Genomes to Systems",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W2556142403 | Reorientation of Sputnik Planitia implies a subsurface ocean on Pluto | The deep nitrogen-covered Sputnik Planitia (SP; informal name) basin on Pluto is located very close to the longitude of Pluto's tidal axis[1] and may be an impact feature [2], by analogy with other large basins in the solar system[3,4]. Reorientation[5-7] due to tidal and rotational torques can explain SP's location, b... | [
"Universe Sciences",
"Earth System Science"
] |
10.1038/nature10925 | DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation | Alternative messenger RNA splicing is the main reason that vast mammalian proteomic complexity can be achieved with a limited number of genes. Splicing is physically and functionally coupled to transcription, and is greatly affected by the rate of transcript elongation. As the nascent pre-mRNA emerges from transcribing... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.3150/17-BEJ958 | Applications Of Pathwise Burkholder Davis Gundy Inequalities | We present several applications of the pathwise Burkholder-Davis-Gundy (BDG) inequalities. Most importantly we prove them for cadlag semimartingales and a general function $\Phi$, and use this to derive BDG inequalities (non-pathwise ones) for the Bessel process of order $\alpha\geq 1$ and for martingales stopped at $\... | [
"Mathematics"
] |
10.4155/fmc.15.188 | Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of Jumonji C domain-containing histone demethylases | Background: Aberrant expression of iron(II)- and 2-oxoglutarate-dependent JumonjiC histone demethylases has been linked to cancer. Potent demethylase inhibitors are drug candidates and biochemical tools to elucidate the functional impact of demethylase inhibition. Methods & results: Virtual screening identified a novel... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Synthetic Chemistry and Materials"
] |
10.1016/j.ymthe.2017.03.001 | Current Progress in Non-viral RNAi-Based Delivery Strategies to Lymphocytes | RNAi-based therapy holds great promise, as it can be utilized for the treatment of multiple conditions in an accurate manner via sequence-specific manipulation of gene expression. To date, RNAi therapeutics have advanced into clinical trials for liver diseases and solid tumors; however, delivery of RNAi to leukocytes i... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Synthetic Chemistry and Materials"
] |
10.1109/TNB.2019.2946124 | Impact Of Long Term Plasticity On Information Transmission Over Neuronal Networks | The realization of bio-compatible nanomachines would pave the way for developing novel diagnosis and treatment techniques for the dysfunctions of intra-body nanonetworks and revolutionize the traditional healthcare methodologies making them less invasive and more efficient. The network of these nanomachines is aimed to... | [
"Neuroscience and Disorders of the Nervous System",
"Systems and Communication Engineering",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
W1988275863 | The Use of Thermowell Bushes at the Triple Point of Water for Improving Repeatability | Water triple point cells are essential for realization of the International Temperature Scale of 1990 (ITS-90). There is some evidence that achieving the ultimate performance of water triple point cells may be restricted by the variation in the position of the platinum resistance thermometer at the bottom of the re-ent... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
W2559960465 | Simulating the water footprint of woodies in Aquacrop and Apex | As the crop cultivation sector is the largest human water consumer, models that simulate its water use are important in global water studies. Within this sector, herbaceous plants and woody plants can be discriminated. Aquacrop is a plant simulation model very capable of simulating herbaceous plants, but the carry-over... | [
"Computer Science and Informatics",
"Earth System Science"
] |
W2484708630 | Species delimitation and phylogeographic analyses in the<i>Ectocarpus</i>subgroup<i>siliculosi</i>(Ectocarpales, Phaeophyceae) | The genus Ectocarpus (Ectocarpales, Phaeophyceae) contains filamentous algae widely distributed in marine and estuarine habitats of temperate regions in both hemispheres. While E. siliculosus has become a model organism for genomics and genetics of the brown macroalgae, accurate species delineation, distribution patter... | [
"Environmental Biology, Ecology and Evolution",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1126/scisignal.2001617 | PI3Kβ plays a critical role in neutrophil activation by immune complexes | Neutrophils are activated by immunoglobulin G (IgG)-containing immune complexes through receptors that recognize the Fc portion of IgG (FcγRs). Here, we used genetic and pharmacological approaches to define a selective role for the β isoform of phosphoinositide 3-kinase (PI3KβcγR- dependent activation of mouse neutroph... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1007/978-3-319-56617-7_2 | Scrypt Is Maximally Memory Hard | Memory-hard functions (MHFs) are hash algorithms whose evaluation cost is dominated by memory cost. As memory, unlike computation, costs about the same across different platforms, MHFs cannot be evaluated at significantly lower cost on dedicated hardware like ASICs. MHFs have found widespread applications including pas... | [
"Computer Science and Informatics"
] |
W1982645109 | A mechanism stabilizing a long-lived charge-separated state of photosynthetic reaction centers frozen under intense illumination | It is experimentally shown that slow chilling of photosynthetic reaction centers from purple bacteria Rhodobacter sphaeroides to <230 K under intense illumination leads to appearance of long-lived chargeseparated states (P+Q −A ). This longevity implies that the recombination is blocked or the charge-separated state is... | [
"Condensed Matter Physics",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1038/nature11986 | Succinate is an inflammatory signal that induces IL-1β through HIF-1α | Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macroph... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing"
] |
W1979337877 | Challenges of using an AUV to find and map hydrothermal vent sites in deep and rugged terrains | In March 2010, the Autosub6000 AUV embarked on a cruise to discover, locate and map hydrothermal vent sites in an active spreading centre, the Cayman trough in the Caribbean sea. The environment provided the challenge of steep and rugged terrain together with deep water (in places greater than 5000 m). Autosub6000 is a... | [
"Products and Processes Engineering",
"Earth System Science"
] |
10.1038/ncb2381 | Shaping development with ESCRTs | Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1515/zpch-2016-0879 | Tetrazole-Stabilized Gold Nanoparticles for Catalytic Applications | Abstract
Herein, we report on a proof-of-concept application of tetrazole-stabilized Au nanoparticles (NPs) for CO oxidation. After impregnation of the support material TiO2 with the tetrazole-stabilized Au NPs (diameter<5 nm), a thermal heat treatment under oxygen is used to remove the tetrazole from the NP surface. T... | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials",
"Materials Engineering"
] |
10.1016/j.neuron.2012.10.037 | Nuclear Calcium Signaling in Spinal Neurons Drives a Genomic Program Required for Persistent Inflammatory Pain | Persistent pain induced by noxious stimuli is characterized by the transition from normosensitivity to hypersensitivity. Underlying mechanisms are not well understood, although gene expression is considered important. Here, we show that persistent nociceptive-like activity triggers calcium transients in neuronal nuclei... | [
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1038/s41893-019-0454-4 | Human impacts on planetary boundaries amplified by Earth system interactions | The planetary boundary framework presents a ‘planetary dashboard’ of humanity’s globally aggregated performance on a set of environmental issues that endanger the Earth system’s capacity to support humanity. While this framework has been highly influential, a critical shortcoming for its application in sustainability g... | [
"Earth System Science",
"Human Mobility, Environment, and Space"
] |
885090 | Holographic control of visual circuits | The aim of this research program is to produce novel all-optical technologies to explore brain functions at the mesoscopic scale with cellular resolution opening a new phase in optogenetics that I named circuit optogenetics.
Revealing the neural codes supporting specific mammalian brain functions is a daunting task de... | [
"Neuroscience and Disorders of the Nervous System",
"Systems and Communication Engineering",
"Physical and Analytical Chemical Sciences"
] |
10.1038/nm.4046 | Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing T<inf>H</inf>17 cells and preserving group 3 innate lymphoid cells | RAR-related orphan receptor-γt (ROR-γt) directs differentiation of proinflammatory T helper 17 (TH17) cells and is a potential therapeutic target in chronic autoimmune and inflammatory diseases. However, ROR-γt-dependent group 3 innate lymphoid cells ILC3s provide essential immunity and tissue protection in the intesti... | [
"Immunity, Infection and Immunotherapy",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W2050965561 | Numerical study on flow behavior of CO2 in an aquifer for risk assessment of carbon capture and storage | Abstract It is supposed that the leakage of injected CO 2 as the principal hazard due to the existence of fault occurs when CO 2 storage in an aquifer is targeted. Therefore it is very important to predict the migration of injected CO 2 dependent on time and space under the environment of underground. The quantitative ... | [
"Earth System Science",
"Products and Processes Engineering"
] |
W2165282058 | Application of Geo-Spatial Techniques for Precise Demarcation of Village/Panchayat Boundaries | Abstract. In order to achieve the overall progress of the country with active and effective participation of all sections of society, the 12th Five Year Plan (FYP) would bring Panchayats centre-stage and achieve the inclusive growth agenda through inclusive governance. The concept of 'democratic decentralization' in th... | [
"Human Mobility, Environment, and Space",
"Computer Science and Informatics",
"Earth System Science"
] |
10.3109/03008207.2014.912645 | Cell Tissue Interactions In Osteoarthritic Human Hip Joint Articular Cartilage | AbstractVolume and morphology of chondrocytes in osteoarthritic human hip joint articular cartilage were characterized, and their relationship to tissue structure and function was determined. Human osteochondral articular cartilage samples (n = 16) were obtained from the femoral heads of nine patients undergoing total ... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Physiology in Health, Disease and Ageing"
] |
10.1016/j.cub.2018.02.037 | Accuracy of Rats in Discriminating Visual Objects Is Explained by the Complexity of Their Perceptual Strategy | Despite their growing popularity as models of visual functions, it remains unclear whether rodents are capable of deploying advanced shape-processing strategies when engaged in visual object recognition. In rats, for instance, pattern vision has been reported to range from mere detection of overall object luminance to ... | [
"Neuroscience and Disorders of the Nervous System",
"The Human Mind and Its Complexity"
] |
BR 112021025552 A | Junta roscada com ressalto produzido por fabricação aditiva | junta roscada com ressalto produzido por fabricação aditiva. a presente invenção refere-se a uma junta roscada tubular (1) para a perfuração, a exploração dos poços de hidrocarbonetos ou o transporte de petróleo e de gás, compreendendo um elemento tubular roscado macho (2) e um elemento tubular roscado (fêmea (3), o el... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
W1974685209 | 7-Substituted pterins provide a new direction for ricin A chain inhibitors | Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the discovery of new inhibitors of great importance. We have previously used 6-... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
FR 7731128 A | PROCEDE DE SECHAGE DE LINGE ET ARMOIRE DE SECHAGE POUR LA MISE EN PRATIQUE DE CE PROCEDE | <P>La présente invention a pour objet une armoire de séchage de linge ou d'autres articles plats. </P><P>Cette armoire, comportant une porte d'alimentation, une ouverture d'aspiration d'air, un ventilateur, un dispositif de séchage de l'air de séchage, et des tiges s'étendant entre une premiere et une seconde paroi, es... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
10.1088/1367-2630/15/4/045020 | Adaptive Tuning Of Majorana Fermions In A Quantum Dot Chain | We suggest a way to overcome the obstacles that disorder and high density of states pose to the creation of unpaired Majorana fermions in one-dimensional systems. This is achieved by splitting the system into a chain of quantum dots, which are then tuned to the conditions under which the chain can be viewed as an effec... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences"
] |
10.2140/ant.2019.13.19 | Variance of arithmetic sums and l-functions in f <inf>q</inf> [t] | We compute the variances of sums in arithmetic progressions of arithmetic functions associated with certain L-functions of degree 2 and higher in F q [t], in the limit as q →∞. This is achieved by establishing appropriate equidistribution results for the associated Frobenius conjugacy classes. The variances are thus re... | [
"Mathematics"
] |
W2040966157 | Beyond the Internet:Mētis,Techne, and the Limitations of Online Artifacts for Islamist Terrorists | This study challenges the conventional wisdom that the Internet is a reliable source of operational knowledge for terrorists, allowing them to train for terrorist attacks without access to real-world training camps and practical experience. The article distinguishes between abstract technical knowledge (what the Greeks... | [
"The Social World and Its Interactions",
"Institutions, Governance and Legal Systems"
] |
10.1007/s10021-014-9793-1 | The Carbon Cycle of a Maritime Ancient Temperate Broadleaved Woodland at Seasonal and Annual Scales | This study compares different approaches to quantifying the carbon cycle in a temperate deciduous forest at Wytham Woods in England, which is unusual in its maritime climate and mixed age structure, reflecting low levels of past management. We tested whether eddy covariance and biometric measurements gave consistent es... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution"
] |
10.1109/ESSDERC.2012.6343381 | Mtj Based Implication Logic Gates And Circuit Architecture For Large Scale Spintronic Stateful Logic Systems | Because of the easy integration with CMOS, non-volatility, reconfiguration capability, and fast-switching speed of magnetic tunnel junctions (MTJs), this work proposes and investigates stateful IMP-based logic gates and circuit architecture for future reconfigurable and nonvolatile computing systems. Stateful logic use... | [
"Condensed Matter Physics",
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
10.1007/jhep03(2020)064 | Asymptotic dynamics of AdS3 gravity with two asymptotic regions | The asymptotic dynamics of AdS3 gravity with two asymptotically anti-de Sitter regions is investigated, paying due attention to the zero modes, i. e. , holonomies along non-contractible circles and their canonically conjugates. This situation covers the eternal black hole solution. We derive how the holonomies around t... | [
"Fundamental Constituents of Matter",
"Mathematics"
] |
W2155381325 | Bayesian neural networks for detecting epistasis in genetic association studies | Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the presence of gene-gene interactions. A non-parametric Bayesian approach in the form o... | [
"Integrative Biology: from Genes and Genomes to Systems",
"Computer Science and Informatics"
] |
3733129 | Negotiation and mediation sensible issues' solutions | Inspired by the greek goddess Nemesis, personification of ""Distribution of Justice"", neither good nor bad, simply in due proportion to each according to what was deserved.
My research is focused on new dispute resolution methods, applying also new technologies, especially online dispute resolution platforms.
Seraphin... | [
"Institutions, Governance and Legal Systems",
"Computer Science and Informatics",
"Individuals, Markets and Organisations"
] |
10.1002/hep.27651 | Potential of Human Induced Pluripotent Stem Cells in Studies of Liver Disease | Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long-ter... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1016/j.bpj.2019.11.3383 | Physiochemical Modeling of Vesicle Dynamics upon Osmotic Upshift | We modeled the relaxation dynamics of (lipid) vesicles upon osmotic upshift, taking into account volume variation, chemical reaction kinetics, and passive transport across the membrane. We focused on the relaxation kinetics upon addition of impermeable osmolytes such as KCl and membrane-permeable solutes such as weak a... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
W2060325669 | Identity-based trapdoor mercurial commitments and applications | In this paper, we first introduce the notion of identity-based trapdoor mercurial commitment which enjoys the advantages of both the identity-based trapdoor commitment and trapdoor mercurial commitment, while using the idea of “Customized Identity”. Inherently, an identity-based trapdoor mercurial commitment is an unde... | [
"Computer Science and Informatics"
] |
10.1007/978-3-319-23461-8_32 | Interactively Exploring Supply And Demand In The Uk Independent Music Scene | We present an exploratory data mining tool useful for finding patterns in the geographic distribution of independent UK-based music artists. Our system is interactive, highly intuitive, and entirely browser-based, meaning it can be used without any additional software installations from any device. The target audiences... | [
"Computer Science and Informatics",
"Human Mobility, Environment, and Space"
] |
W189981494 | Fault Detection and Circuit Analysis of INSTRON 1603 Fatigue Testing Machine | Instron 1603 is a fatigue testing machine imported from England in 1987. This machine works on electromagnetic principle. Instron is presently supplying 8000’s series which are Hydraulic Based machines. 1603 can be used for testing up to 120 Hz load cycle where as the present machines can be used until 10Hz load cycle,... | [
"Systems and Communication Engineering",
"Products and Processes Engineering"
] |
10.1111/j.1474-9726.2009.00463.x | Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice | Cockayne syndrome and other segmental progerias with inborn defects in DNA repair mechanisms are thought to be due in part to hypersensitivity to endogenous oxidative DNA damage. The accelerated aging-like symptoms of this disorder include dysmyelination within the central nervous system, progressive sensineuronal hear... | [
"Physiology in Health, Disease and Ageing",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W1988443096 | Research Integrity in Communication Sciences and Disorders: Preface | Purpose A joint program on Research on Research Integrity sponsored by the National Institute of Neurological Disorders and Stroke and the Office of Research Integrity encouraged the examination of practices and policies promoting the responsible conduct of research (RCR). The authors' grant—Research Integrity in ASHA:... | [
"The Social World and Its Interactions"
] |
EP 9701339 W | PROCESS FOR PREPARING ALKOXYLATED FATTY ACID ALKYL ESTERS | The invention concerns a process for alkoxylating fatty acid alkyl esters, fatty acid esters being reacted in a manner known per se with alkylene oxides in the presence of double-layer mixed oxide catalysts and co-catalysts selected from the group comprising lithium hydroxide, alkaline earth salts and tin salts. The no... | [
"Synthetic Chemistry and Materials",
"Products and Processes Engineering"
] |
10.7554/eLife.14119 | A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies | The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytoplasmic exchange. It consists of nucleoporin domains rich in phenylalanine-glycine motifs (FG domains). As a bottom-up nanoscale model for the permeability barrier, we have used planar films produced with three different end-grafted FG do... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
W2353162123 | Analysis on the Questionnaire Design of Public Meteorological Service Benefit in Jiangsu Province | The quality of questionnaire design had a direct influence on the data compilation and results analysis of questionnaire.Combining with the questionnaire design of public meteorological service benefit in Jiangsu Province,the control of questionnaire design quality was put forward,namely,we should develop from three as... | [
"Earth System Science",
"The Social World and Its Interactions"
] |
W2028104859 | Integrated biomarker response index using a Neotropical fish to assess the water quality in agricultural areas | Aquatic ecosystems in areas with intense agricultural activity are subject to pesticide contamination, which may compromise the health of the fish. In order to verify the quality of the water and the possible effects of pesticides on fish, a method that combines different biomarker responses into an index named "integr... | [
"Environmental Biology, Ecology and Evolution",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing"
] |
W2002036498 | Sequencing Analysis of the ATOH7 Gene in Individuals with Optic Nerve Hypoplasia | The Atonal Homolog 7 (ATOH7) gene has been implicated in association studies with optic nerve head diameter size. Hence, we screened optic nerve hypoplasia (ONH) patient DNA samples from Australia, France, and the United States for sequence variants in theATOH7 gene using Sanger sequencing.Sanger sequencing of theATOH7... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
W1606352554 | Glottal gap as an early predictor for permanent laryngoplasty in unilateral vocal fold paralysis | To assess the possible predictive factors for permanent laryngoplasty (PL) in patients with acute unilateral vocal fold paralysis (UVFP), and to assess the effects of early vocal cord hyaluronic acid injection.Prospective cohort study.Patients diagnosed with UVFP within the previous 6 months were enrolled. Initial and ... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Physiology in Health, Disease and Ageing"
] |
interreg_1201 | Environmental Park | EPA supports the strengthening and promotion of the protected areas involved in the project through their sustainable use. The long-term goal is the seasonal adjustment of tourism in the territories that is not connected only to the sea and to the summer. The specific objectives of the project are:
o to promote sustain... | [
"Products and Processes Engineering",
"Environmental Biology, Ecology and Evolution"
] |
W2805623367 | Inflation expectations and the recovery from the Great Depression in Germany | Abstract A regime shift toward increased inflation expectations is credited with jump-starting the recovery from the Great Depression in the United States. What role did inflation expectations play in Germany that experienced a similarly successful economic upturn in the 1930s? We study inflation expectations in the Ge... | [
"Individuals, Markets and Organisations",
"The Study of the Human Past"
] |
US 84894104 A | Dynamic interface software for wireless communication devices | The present invention provides an improved wireless communication device capable of detecting the presence of an external device and dynamically updating its communication abilities to facilitate communication with the external device. The wireless communication device, upon detecting a wired or wireless connection fro... | [
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
10.1029/2009GL042145 | Crustal Structure Beneath Montserrat Lesser Antilles Constrained By Xenoliths Seismic Velocity Structure And Petrology | [1] Noritic anorthosite, gabbroic anorthosite and hornblende-gabbro xenoliths are ubiquitous in the host andesite at Montserrat. Other xenoliths include quartz diorite, metamorphosed biotite-gabbro, plagioclase-hornblendite and plagioclase-clinopyroxenite. Mineral compositions suggest a majority of the xenoliths are co... | [
"Earth System Science",
"Physical and Analytical Chemical Sciences"
] |
222983 | Accurate intravenous therapy for every patient | Intravenous (IV) therapy involves administration of fluids or medications through a needle or a catheter and it is administered to over 90% of hospitalised patients. Although a simple procedure, a balanced IV therapy has a significant impact by reducing the number of complications by 59% and the length of hospital stay... | [
"Products and Processes Engineering",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.3389/feart.2018.00012 | Spatial variability in patterns of glacier change across the manaslu range, central himalaya | This study assesses changes in glacier area, velocity, and geodetic mass balance for the glaciers in the Manaslu region of Nepal, a previously undocumented region of the Himalayas. We studied changes between 1970 (for select glaciers), 2000, 2005, and 2013 using freely available Landsat satellite imagery, the SRTM Digi... | [
"Earth System Science"
] |
interreg_3266 | SHARE - Sustainable Hydropower in Alpine Rivers Ecosystems | Hydropower is the most important renewable resource for electricity production in alpine areas: it has advantages for the global CO2 balance but creates serious environmental impacts. RES-e Directives require a renewable electricity enhance but, at the same time, the Water Framework Directive obliges member States to r... | [
"Earth System Science",
"Products and Processes Engineering",
"Environmental Biology, Ecology and Evolution"
] |
10.1214/17-EJS1339SI | Poisson Intensity Estimation With Reproducing Kernels | Despite the fundamental nature of the inhomogeneous Poisson process in the theory and application of stochastic processes, and its attractive generalizations (e. g. Cox process), few tractable nonparametric modeling approaches of intensity functions exist, especially when observed points lie in a high-dimensional spac... | [
"Mathematics",
"Computer Science and Informatics"
] |
10.1094/MPMI-07-15-0147-R | Tomato I2 Immune Receptor Can Be Engineered To Confer Partial Resistance To The Oomycete Phytophthora Infestans In Addition To The Fungus Fusarium Oxysporum | Plants and animals rely on immune receptors, known as nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins, to defend against invading pathogens and activate immune responses. How NLR receptors respond to pathogens is inadequately understood. We previously reported single-residue mutations that e... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
US 0213316 W | OPTICAL LENS COATING AND METHOD | An optical lens having a colored coating affixed to the edge (110) of the lens. The apparatus may enhance the cosmetic appearance of eyeglasses (200) by reducing the appearance of the white ring appearing along the perimeter of the face (120) of lens when viewing eyeglasses from the front, and by reducing the appearanc... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
interreg_3380 | Save Our Lives. A Comprehensive Road Safety Strategy for Central Europe
| Every year more than 40,000 people lose their lives on Europe’s roads. In the EU, 1 out of every 5 child deaths due to injury are a result of road crashes. While many western European countries are making continuous progress in reducing the number of lives lost, fatality rates in many new Member States in the Central E... | [
"Human Mobility, Environment, and Space",
"Institutions, Governance and Legal Systems"
] |
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