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10. 1002/advs. 202103554 | 2,022 | Advanced Science | Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture | Abstract In this work, a two component microgel assembly using soft anisometric microgels that interlink to create a 3D macroporous construct for cell growth is reported. Reactive microgel rods with variable aspect ratio are produced via microfluidics in a continuous plug‐flow on‐chip gelation method by photoinitiated ... | 1 Introduction To understand interactions between living matter and artificial materials, tissue engineering research groups focus on the development of 3D scaffolds with increasingly controllable properties, reaching from biochemical interactions at molecular scale to nanoscale hydrogel networks, micrometer‐scale pore... |
10. 1002/advs. 202103693 | 2,021 | Advanced Science | Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization | Abstract Although deoxyribonucleic acid (DNA) is the genetic coding for the very essence of life, these macromolecules or components thereof are not necessarily lost after a cell dies. There appears to be a link between extracellular DNA and biomineralization. Here the authors demonstrate that extracellular DNA functio... | 1 Introduction Research on the properties of nucleic acids has never ceased since the discovery of the double helix structure of deoxyribonucleic acids (DNA) in 1868. [ 1 ] Over the past 150 years, investigations in the functions of DNA have proceeded from the cellular level to the molecular level. It is now known that... |
10. 1002/advs. 202103820 | 2,022 | Advanced Science | Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications | Abstract Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for surgical bone repair, but the multihierarchical complexity of natural bone is still difficult to emulate due to the lack of suitable biomaterials. Supramolecular peptide nanofiber hydrogels (SPNHs) are emerging biomater... | 1 Introduction Bone is a highly mineralized and neurovascularized hierarchical tissue that shows potential of self‐healing after injuries. However, clinic failure on bone fracture healing may vary from 5% to 10%, which is correlated with various risk factors, including serious injury, diabetes, osteoporosis, obesity, a... |
10. 1002/advs. 202103875 | 2,022 | Advanced Science | 3D Printed Personalized Nerve Guide Conduits for Precision Repair of Peripheral Nerve Defects | Abstract The treatment of peripheral nerve defects has always been one of the most challenging clinical practices in neurosurgery. Currently, nerve autograft is the preferred treatment modality for peripheral nerve defects, while the therapy is constantly plagued by the limited donor, loss of donor function, formation ... | 1 Introduction Peripheral nerve injury (PNI) is a common disease that always results in loss of sensory and motor function. [ 1 ] PNI is often caused by violent behaviors, motor vehicle accidents, and iatrogenic injuries. [ 2 ] Generally, peripheral nerves have a solid ability to regenerate after injury. [ 3 ] In the p... |
10. 1002/advs. 202103939 | 2,022 | Advanced Science | Quantifying Cell‐Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model | Abstract Dysregulation of extracellular matrix (ECM) synthesis, organization, and mechanics are hallmark features of diseases like fibrosis and cancer. However, most in vitro models fail to recapitulate the three‐dimensional (3D) multi‐scale hierarchical architecture of collagen‐rich tissues and as a result, are unable... | 1 Introduction The precise composition and spatial distribution of cells and extracellular matrix (ECM) directly correspond to tissue function. While there has been significant attention devoted to understanding how cellular dysregulation contributes to disease, more recently there has been increased focus on investiga... |
10. 1002/advs. 202103981 | 2,021 | Advanced Science | From Mesoscopic Functionalization of Silk Fibroin to Smart Fiber Devices for Textile Electronics and Photonics | Abstract Bombyx mori silk fibers exhibit significant potential for applications in smart textiles, such as fiber sensors, fiber actuators, optical fibers, and energy harvester. Silk fibroin (SF) from B. mori silkworm fibers can be reconstructed/functionalized at the mesoscopic scale during refolding from the solution s... | 1 Introduction Fibrous or textile electronics and photonics are devices integrated in flexible yarns or textiles that perform smart sensing or logic functions. [ 1, 2 ] This special type of electronic or photonic elements significantly impact smart clothes, [ 3 ] which are applicable for movable energy harvesting, [ 4,... |
10. 1002/advs. 202104165 | 2,022 | Advanced Science | Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair | Abstract Wound healing is a long‐term, multistage biological process that includes hemostasis, inflammation, proliferation, and tissue remodeling and requires intelligent designs to provide comprehensive and convenient treatment. The complexity of wounds has led to a lack of adequate wound treatment materials, which mu... | 1 Introduction Wounds produced by trauma, burns, surgery, and chronic diseases cause many millions of patients to suffer discomfort, pain, and, in severe cases, disability. [ 1 ] The burden of chronic wounds is growing due to the increasing incidence of obesity and diabetes, resulting in therapeutic problems and increa... |
10. 1002/advs. 202104272 | 2,021 | Advanced Science | Nanomotor‐Derived Porous Biomedical Particles from Droplet Microfluidics | Abstract Porous particles have found widespread applications in therapeutic diagnosis, drug delivery, and tissue engineering due to their typical properties of large surface area, extensive loading capacity, and hierarchical microstructures. Attempts in this aspect are focusing on the development of effective methods t... | 1 Introduction Owing to the characteristic features of enhanced surface area, excellent loading capacity, and hierarchical architecture, porous particles have demonstrated great values in various biomedical fields, such as multiplexed bioassays, controlled drug delivery, noninvasive diagnosis, cosmetic industry, pollut... |
10. 1002/advs. 202104299 | 2,022 | Advanced Science | hESCs‐Derived Early Vascular Cell Spheroids for Cardiac Tissue Vascular Engineering and Myocardial Infarction Treatment | Abstract Transplanting functional cells to treat myocardial infarction (MI), a major disease threatening human health, has become the focus of global therapy. However, the efficacy has not been well anticipated, partly due to the lack of microvascular system that supplies nutrients and oxygen. Here, spheroids of early ... | 1 Introduction Myocardial infarction (MI) induced myocardium ischemia can cause massive loss of cardiomyocytes (CMs) which have limited regenerative capacity in adult heart. [ 1 ] With the rapid development of directed differentiation technology of cardiac cells from human pluripotent stem cells (hPSCs), cell therapy f... |
10. 1002/advs. 202104362 | 2,022 | Advanced Science | High‐Frequency Ultrasound Boosts Bull and Human Sperm Motility | Abstract Sperm motility is a significant predictor of male fertility potential and is directly linked to fertilization success in both natural and some forms of assisted reproduction. Sperm motility can be impaired by both genetic and environmental factors, with asthenozoospermia being a common clinical presentation. M... | 1 Introduction Infertility is a rising global health issue that impacts over 70 million couples per year. [ 1 ] Male factor infertility accounts for 50% of infertility cases, primarily mediated by deficits in sperm number and/or function. [ 2, 3, 4 ] Sperm motility plays a central role in both natural fertilization and... |
10. 1002/advs. 202104424 | 2,022 | Advanced Science | Regulation of Neural Differentiation of ADMSCs using Graphene‐Mediated Wireless‐Localized Electrical Signals Driven by Electromagnetic Induction | Abstract Although adipose‐derived mesenchymal stem cells (ADMSCs) isolated from patients’ fat are considered as the most important autologous stem cells for tissue repair, significant difficulties in the neural differentiation of ADMSCs still impede stem cell therapy for neurodegenerative diseases. Herein, a wireless‐e... | 1 Introduction Neurodegenerative diseases occur in the central, peripheral, and autonomic nervous systems and are characterized by sensory, motor, conscious, and autonomic dysfunctions. [ 1 ] The main pathology of neurological diseases is the progressive loss of functional neurons, which fail to translate nervous impul... |
10. 1002/advs. 202104451 | 2,022 | Advanced Science | Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip | Abstract Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high interest for therapeutic strategies. To gain insights into mechanisms of adipose (patho‐)physiology, researchers traditionally relied... | 1 Introduction Obesity, defined by a body mass index (BMI) of 30 or above, has reached epidemic proportions globally. About 13% of the world's adult population was obese in 2016— [ 1 ] and this number has continued to rise. Marked by a state of low‐grade chronic inflammation, obesity is a well‐recognized risk factor fo... |
10. 1002/advs. 202104649 | 2,022 | Advanced Science | Directing Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells | Abstract Multicellular organization with precise spatial definition is essential to various biological processes, including morphogenesis, development, and healing in vascular and other tissues. Gradients and patterns of chemoattractants are well‐described guides of multicellular organization, but the influences of 3D ... | 1 Introduction Multicellular spatial organization drives morphogenesis, development, healing, and homeostasis, [ 1, 2, 3, 4, 5 ] and its disruption has been implicated in the onset of diseases and the development of pathobiological processes as diverse as hypertension and malignancy. [ 6, 7, 8, 9, 10 ] Multicellular or... |
10. 1002/advs. 202104843 | 2,022 | Advanced Science | Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications | Abstract Infections are regarded as the most severe complication associated with human health, which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic platforms for antibacterial treatments, which provide great potential for accurate theranostics. In this review, the advantages, the respon... | 1 Introduction Infections, especially hospital‐acquired infections, present a worldwide healthcare risk and cause severe casualties every year. Similar to the COVID‐19 pandemic, the spread of drug‐resistance endangers public health. If left unchecked, by 2050, bacterial infections might cause the death of about 10 mill... |
10. 1002/advs. 202105146 | 2,022 | Advanced Science | Biodegradable Elastomers and Gels for Elastic Electronics | Abstract Biodegradable electronics are considered as an important bio‐friendly solution for electronic waste (e‐waste) management, sustainable development, and emerging implantable devices. Elastic electronics with higher imitative mechanical characteristics of human tissues, have become crucial for human‐related appli... | 1 Introduction The development of electronics has brought great convenience to human life and significantly improved the standard of healthcare, education, and security. There is an increasing dependence of human beings on electronics in daily life. Owing to the restriction of industrial materials, the consumer electro... |
10. 1002/advs. 202105152 | 2,022 | Advanced Science | Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors | Abstract Skin wound repair is a multistage process involving multiple cellular and molecular interactions, which modulate the cell behaviors and dynamic remodeling of extracellular matrices to maximize regeneration and repair. Consequently, abnormalities in cell functions or pathways inevitably give rise to side effect... | 1 Introduction Skin is the largest organ of the body, composed of various cell types that interact in a highly coordinated manner to maintain homeostasis. [ 1 ] Cutaneous injuries, particularly chronic wounds, require long‐term treatment and place an enormous economic burden on healthcare systems. The prevalence of chr... |
10. 1002/advs. 202105254 | 2,021 | Advanced Science | Biophysical Approaches for Applying and Measuring Biological Forces | Abstract Over the past decades, increasing evidence has indicated that mechanical loads can regulate the morphogenesis, proliferation, migration, and apoptosis of living cells. Investigations of how cells sense mechanical stimuli or the mechanotransduction mechanism is an active field of biomaterials and biophysics. Ga... | 1 Introduction Mechanical sensing and response are essential for cells and tissues to retain their normal functions. Stretching, compressive, and shear forces, as well as forces derived from surface tension, are the common mechanical cues that cells are continuously subjected to in vivo. Cells inside tissues are surrou... |
10. 1002/advs. 202105319 | 2,022 | Advanced Science | Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing | Abstract With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue‐based in vit... | 1 Introduction Animal testing is a common approach in industry and academia to classify the risks and effects of pharmaceutics, pesticides, biocides, and food additives on the environment and humans. [ 1 ] However, their use simultaneously raises questions as well as pros and cons of moral and ethical nature that have ... |
10. 1002/advs. 202105325 | 2,022 | Advanced Science | Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D | Abstract While matrix stiffness regulates cell behavior on 2D substrates, recent studies using synthetic hydrogels have suggested that in 3D environments, cell behavior is primarily impacted by matrix degradability, independent of stiffness. However, these studies did not consider the potential impact of other confound... | 1 Introduction Adhesive interactions between cells and their surrounding extracellular matrix (ECM) regulate many basic cellular functions, [ 1 ] such as spreading, [ 2 ] migration, [ 3 ] proliferation, [ 4 ] or stem cell differentiation. [ 5 ] Thus, understanding these interactions is critical for the design of novel ... |
10. 1002/advs. 202105373 | 2,022 | Advanced Science | Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles | Abstract Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organ... | 1 Introduction Developments in nanotechnology have contributed to substantial progress in designing precision nanocarriers for advanced drug delivery. [ 1, 2 ] Subsequently, these nanocarriers have shown tremendous potential to overcome the limitations of otherwise solo drugs and navigate through biological barriers to... |
10. 1002/advs. 202105571 | 2,022 | Advanced Science | Kartogenin‐Conjugated Double‐Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair | Abstract The effectiveness of existing tissue‐engineering cartilage (TEC) is known to be hampered by weak integration of biocompatibility, biodegradation, mechanical strength, and microenvironment supplies. The strategy of hydrogel‐based TEC holds considerable promise in circumventing these problems. Herein, a non‐toxi... | 1 Introduction Cartilage injury has increased social and economic burdens as a common joint disease. [ 1 ] The regeneration of cartilage, an avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Current clinical approaches include osteochondral transplantation, b... |
10. 1002/advs. 202105586 | 2,022 | Advanced Science | Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth | Abstract Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury (SCI) repair because they match the electrical and mechanical properties of neural tissue. However, electroconductive hydrogel implantation can potentially aggravate inflammation, and hinder its repair efficacy. Bone ... | 1 Introduction An estimated 27 million people live with long‐term disability following spinal cord injury (SCI) worldwide, with ≈180 000 new cases occurring each year. [ 1 ] SCI is followed by neuronal loss and axon and myelin necrosis, which leads to an extensive inflammatory response and further exacerbates secondary... |
10. 1002/advs. 202105694 | 2,022 | Advanced Science | Regenerating the Injured Spinal Cord at the Chronic Phase by Engineered iPSCs‐Derived 3D Neuronal Networks | Abstract Cell therapy using induced pluripotent stem cell‐derived neurons is considered a promising approach to regenerate the injured spinal cord (SC). However, the scar formed at the chronic phase is not a permissive microenvironment for cell or biomaterial engraftment or for tissue assembly. Engineering of a functio... | 1 Introduction Traumatic spinal cord injury (SCI) has an immediate and catastrophic impact on movement control and on all aspects of the patient's health and quality of life. The primary trauma injury causes direct damage, which often leads to death of cells, disruption to blood‐SC barrier, and degradation of the extra... |
10. 1002/advs. 202105701 | 2,022 | Advanced Science | Foam 3D Printing of Thermoplastics: A Symbiosis of Additive Manufacturing and Foaming Technology | Abstract Due to their light‐weight and cost‐effectiveness, cellular thermoplastic foams are considered as important engineering materials. On the other hand, additive manufacturing or 3D printing is one of the emerging and fastest growing manufacturing technologies due to its advantages such as design freedom and tool‐... | 1 Introduction Foaming of thermoplastics results in more sustainable, lighter, and less expensive components for a variety of commodity and engineering applications. This is while the foamed structures encounter less shrinkage and better dimensional stability due to the lower material input. [ 1 ] On the other hand, fo... |
10. 1002/advs. 202105727 | 2,022 | Advanced Science | Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration | Abstract Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA remains a big challenge. In this study,... | 1 Introduction Osteoarthritis (OA), a chronic degenerative disease, which is characterized by chronic inflammation and cartilage degradation, leading to cartilage lesion and subchondral bone defect in terminal OA. [ 1, 2 ] Current treatment strategies include microfracture, autograft/allograft, and joint replacement. A... |
10. 1002/advs. 202105783 | 2,022 | Advanced Science | Monitoring the Remodeling of Biohybrid Tissue‐Engineered Vascular Grafts by Multimodal Molecular Imaging | Abstract Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approache... | 1 Introduction Despite major discoveries and successes that occurred in the field of prevention and treatment of cardiovascular diseases, they remain the leading cause of death worldwide. [ 1, 2 ] Cardiovascular pathologies are associated with a broad spectrum of comorbidities, including partial occlusion or complete l... |
10. 1002/advs. 202105945 | 2,022 | Advanced Science | Bioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration | Abstract Control over soft‐to‐hard tissue interfaces is attracting intensive worldwide research efforts. Herein, a bioactive film‐guided soft–hard interface design (SHID) for multi‐tissue integrative regeneration is shown. Briefly, a soft bioactive film with good elasticity matchable to native ligament tissue, is incor... | 1 Introduction The rational design of soft‐to‐hard material interfaces has been attracting accumulating attentions in the fields of tissue engineering and material science. [ 1 ] The integration of multiscale tissues, especially the functional soft‐to‐hard interface integration plays a vital role in both artificial dev... |
10. 1002/advs. 202106008 | 2,022 | Advanced Science | Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators | Abstract Flexible triboelectric nanogenerators (TENGs) have attracted increasing interest since their advent in 2012. In comparison with other flexible electrodes, hydrogels possess transparency, stretchability, biocompatibility, and tunable ionic conductivity, which together provide great potential as current collecto... | 1 Introduction Nowadays, the growing popularity of next‐generation portable and wearable electronics has spurred increasing demands for power sources. [ 1, 2, 3, 4, 5 ] However, the rigid/complicated configuration, large size, and environmentally unfriendly properties of most traditional power supplies no longer satisf... |
10. 1002/advs. 202106049 | 2,022 | Advanced Science | Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations | Abstract Metal‐based nanoparticles (NPs) are particularly important tools in tissue engineering‐, drug carrier‐, interventional therapy‐, and biobased technologies. However, their complex and varied migration and transformation pathways, as well as their continuous accumulation in closed biological systems, cause vario... | 1 Introduction Over the recent decades, nanotechnology has been integrated in many areas of research and industry, including nanomedicine (e. g. , antibacterial, bioimaging, and photothermal therapy), [ 1, 2, 3 ] industrial chemistry (e. g. , catalysis, energy conversion, and sensors), and the production of basic consu... |
10. 1002/advs. 202106076 | 2,022 | Advanced Science | Toward Green Atom Transfer Radical Polymerization: Current Status and Future Challenges | Abstract Reversible‐deactivation radical polymerizations (RDRPs) have revolutionized synthetic polymer chemistry. Nowadays, RDRPs facilitate design and preparation of materials with controlled architecture, composition, and functionality. Atom transfer radical polymerization (ATRP) has evolved beyond traditional polyme... | 1 Introduction Polymers are ubiquitous in our lives. Clothes, shoes, electronic devices, medical equipment, pharmaceuticals, domestic appliances all have polymeric components, as have cars, airplanes, other transportation vehicles or even concrete and pavements. Polymeric materials are characterized by exceptional dura... |
10. 1002/advs. 202170078 | 2,021 | Advanced Science | Large‐Scale Optoacoustic Microscopy: Long‐Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy (Adv. Sci. 13/2021) | Dynamics of tissue revascularization, vessel maturation and remodeling remain poorly understood due to lack of suitable in vivo imaging tools. The new LSOM method offers a versatile tool for tissue engineering and regenerative medicine by empowering label‐free, noninvasive, longitudinal, highthroughput, and quantitativ... | No full text available |
10. 1002/advs. 202200050 | 2,022 | Advanced Science | Material‐Assisted Strategies for Osteochondral Defect Repair | Abstract The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of constraints to bones during movement. The OC unit does not spontaneously heal; therefore, OC defects are considered to be one of the major risk factors for developing long‐term degenerative joint diseases such as o... | 1 Introduction Articular cartilage is a connective tissue present at the extremities of bones in diarthrodial joints, which has major functions in joint lubrication and stress reduction during movement. [ 1 ] These functions are mediated by the highly hydrated and organized matrix of the tissue, whose integrity, define... |
10. 1002/advs. 202200560 | 2,022 | Advanced Science | Sustainable Natural Bio‐Origin Materials for Future Flexible Devices | Abstract Flexible devices serve as important intelligent interfaces in various applications involving health monitoring, biomedical therapies, and human–machine interfacing. To address the concern of electronic waste caused by the increasing usage of electronic devices based on synthetic polymers, bio‐origin materials ... | 1 Introduction The past few decades have witnessed the fast‐growing development of electronic devices. [ 1 ] The rapid advancement of electronic technology has changed our daily lives significantly. [ 2 ] Particularly, flexible electronics that can be conformally attached to curved and dynamic surfaces have been extens... |
10. 1002/advs. 202200670 | 2,022 | Advanced Science | Cells‐Micropatterning Biomaterials for Immune Activation and Bone Regeneration | Abstract Natural tissues are composed of ordered architectural organizations of multiple tissue cells. The spatial distribution of cells is crucial for directing cellular behavior and maintaining tissue homeostasis and function. Herein, an artificial bone bioceramic scaffold with star‐, Tai Chi‐, or interlacing‐shaped ... | 1 Introduction Tissue engineering aims to develop biologically functional substitutes for the purpose of restoring and/or replacing damaged or lost native tissues. One strategy is to incorporate cells within biomaterials to provide a three‐dimensional (3D) microenvironment capable of regulating cell function and ultima... |
10. 1002/advs. 202200882 | 2,022 | Advanced Science | Print‐and‐Grow within a Novel Support Material for 3D Bioprinting and Post‐Printing Tissue Growth | Abstract 3D bioprinting holds great promise for tissue engineering, with extrusion bioprinting in suspended hydrogels becoming the leading bioprinting technique in recent years. In this method, living cells are incorporated within bioinks, extruded layer by layer into a granular support material followed by gelation of... | 1 Introduction A major challenge in tissue engineering is fabricating 3D constructs with structural and functional properties that mimic the 3D environment of living tissue in a reproducible and stable manner. [ 1 ] Recently, 3D bioprinting has gained broad interest for its potential to create such constructs. Specific... |
10. 1002/advs. 202201155 | 2,022 | Advanced Science | Dynamically Responsive Scaffolds from Microfluidic 3D Printing for Skin Flap Regeneration | Abstract Biological scaffolds hold promising perspectives for random skin flap regeneration, while the practical application is greatly limited by their insufficient vascularization ability and the lack of responsiveness during the dynamical healing process. Herein, a novel MXene‐incorporated hollow fibrous (MX‐HF) sca... | 1 Introduction Random skin flaps have been frequently used in orthopedic surgery for repairing or reconstructing tissue defects resulting from trauma, tumor resection, and congenital deformities. [ 1 ] Unfortunately, the skin flap tissues commonly suffer from distal ischemic necrosis due to the insufficient blood suppl... |
10. 1002/advs. 202201226 | 2,022 | Advanced Science | Bioactive Fish Scale Scaffolds with MSCs‐Loading for Skin Flap Regeneration | Abstract Skin flap transplantations are common methods for covering and repairing tissue defects in surgery, while the survival rates of these skin flaps are still low due to the vascular crisis and necrosis. To improve this situation, herein a novel biohybrid scaffold is proposed by integrating the advantages of aniso... | 1 Introduction Random skin flaps are often used in the reconstruction of tissue defects caused by trauma, tumor, infection, and other metabolic diseases. [ 1 ] However, serious complications such as vascular crisis and necrosis may occur after surgery, which could cause the formation of chronic wounds and repeated oper... |
10. 1002/advs. 202201392 | 2,022 | Advanced Science | Embedded 3D Printing in Self‐Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs | Abstract Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain development and disease. Towards this end, embedded printing inside granular gels holds great promise as it allows precise patterning of extremely soft tissue construct... | 1 Introduction Astonishing architectural and operational intricacies of the human brain span multiple length scales to allow precise control of our cognitive and motor functions. Most of our understanding of this complex organ comes from a long tradition of studies using postmortem tissue, animal models, and 2D cell cu... |
10. 1002/advs. 202201415 | 2,022 | Advanced Science | Shielding Surfaces from Viruses and Bacteria with a Multiscale Coating | Abstract The spread of viral and bacterial pathogens mediated by contact with surfaces is a leading cause of infection worldwide. COVID‐19 and the continuous rise of deaths associated with antibiotic‐resistant bacteria highlight the need to impede surface‐mediated transmission. A sprayable coating with an intrinsic abi... | 1 Introduction COVID‐19 has highlighted the global risk associated with the transmission of pathogens, and its rapid and severe impact on human health and the global economy. [ 1, 2 ] There is broad evidence that surfaces facilitate pathogen dissemination, leading to widespread transmission throughout the population. [... |
10. 1002/advs. 202201497 | 2,022 | Advanced Science | Highly Retentive, Anti‐Interference, and Covert Individual Marking Taggant with Exceptional Skin Penetration | Abstract The development of high‐performance individual marking taggants is of great significance. However, the interaction between taggant and skin is not fully understood, and a standard for marking taggants has yet to be realized. To achieve a highly retentive, anti‐interference, and covert individual marking fluore... | 1 Introduction Taggants, which have rapidly emerged as preferable materials for physically or chemically marking an item for unique identification, are used extensively in the fields of anticounterfeiting, [ 1 ] cell tracking, [ 2 ] property marking, [ 3 ] suspect monitoring, [ 4 ] explosives or illegal narcotics track... |
10. 1002/advs. 202201566 | 2,022 | Advanced Science | Freeform 3D Ice Printing (3D‐ICE) at the Micro Scale | Abstract Water is one of the most important elements for life on earth. Water's rapid phase‐change ability along with its environmental and biological compatibility also makes it a unique structural material for 3D printing of ice structures reproducibly and accurately. This work introduces the freeform 3D ice printing... | 1 Introduction Water is the primary building block of any living organism and the most abundant substance on the earth's surface. Although water has been used as a resource for many applications, the use of ice as a structural material is relatively uncommon. However, the simple and rapid phase transition of liquid wat... |
10. 1002/advs. 202201867 | 2,022 | Advanced Science | Programmable Auxeticity in Hydrogel Metamaterials via Shape‐Morphing Unit Cells | Abstract Mechanical metamaterials recruit unique mechanical behavior that is unavailable in bulk materials from a periodic unit cell structure with a specific geometry. However, such metamaterials can typically not be reconfigured once manufactured. Herein, the authors introduce shape morphing of a hydrogel metamateria... | 1 Introduction Mechanical metamaterials are artificial materials that obtain unprecedent responses to mechanical forces due to their specifically designed, usually periodic, architectures. Properties such as ultrahigh stiffness, [ 1, 2 ] negative swelling, [ 3, 4, 5 ] and negative Poisson's ratio [ 6, 7, 8, 9 ] have be... |
10. 1002/advs. 202201947 | 2,022 | Advanced Science | Highly Aligned Bacterial Nanocellulose Films Obtained During Static Biosynthesis in a Reproducible and Straightforward Approach | Abstract Bacterial nanocellulose (BNC) is usually produced as randomly‐organized highly pure cellulose nanofibers films. Its high water‐holding capacity, porosity, mechanical strength, and biocompatibility make it unique. Ordered structures are found in nature and the properties appearing upon aligning polymers fibers ... | 1 Introduction Anisotropic structures are ubiquitous in nature and our tissues, and we find them carrying out particular functions, including mass transport, surface lubrication, cell adhesion, and force generation. For instance, aligned actin fibers confer strong muscle resistance, and highly aligned collagen fibers o... |
10. 1002/advs. 202202058 | 2,022 | Advanced Science | Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral‐Framework Nucleic‐Acid Nanostructures Functionalized with Osteogenic Growth Peptide | Abstract As major complications of chemoradiotherapy, myelosuppression and hematopoietic‐system damage severely affect immunologic function and can delay or even terminate treatment for cancer patients. Although several specific cytokines have been used for hematopoiesis recovery, their effect is limited, and they may ... | 1 Introduction Myelosuppression is a major complication of tumor chemotherapy or radiotherapy. It can cause severe damage to the hemopoietic system and disrupt the bone marrow microenvironment. [ 1 ] It can also lead to further problems, such as infection, hemorrhage, anemia, or even multiple organ failure. [ 2 ] Altho... |
10. 1002/advs. 202202102 | 2,022 | Advanced Science | Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration | Abstract Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting. Nevertheless, limited availability of autografts and potential morbidities in donors hampers its widespread application. Bioactive scaffold‐... | 1 Introduction Peripheral nerve defects are frequently caused by trauma or tumor dissection and are treated by nerve transplantation or reconstruction using various transplant materials. Autologous nerve grafting is the gold standard for treating these defects. [ 1 ] However, this approach is limited by restricted auto... |
10. 1002/advs. 202202181 | 2,022 | Advanced Science | Functional Trachea Reconstruction Using 3D‐Bioprinted Native‐Like Tissue Architecture Based on Designable Tissue‐Specific Bioinks | Abstract Functional segmental trachea reconstruction remains a remarkable challenge in the clinic. To date, functional trachea regeneration with alternant cartilage‐fibrous tissue‐mimetic structure similar to that of the native trachea relying on the three‐dimensional (3D) bioprinting technology has seen very limited b... | 1 Introduction Functional segmental trachea reconstruction has always been a grand challenge in the clinic because the key difficulty in the lack of ideal tracheal substitutes. [ 1, 2, 3 ] The advancement of tissue engineering technologies has offered promising potentials to provide tracheal grafts with certain functio... |
10. 1002/advs. 202202187 | 2,022 | Advanced Science | Ionic Liquid‐Based Polymer Nanocomposites for Sensors, Energy, Biomedicine, and Environmental Applications: Roadmap to the Future | Abstract Current interest toward ionic liquids (ILs) stems from some of their novel characteristics, like low vapor pressure, thermal stability, and nonflammability, integrated through high ionic conductivity and broad range of electrochemical strength. Nowadays, ionic liquids represent a new category of chemical‐based... | 1 Introduction The discovery of water and air‐stable ionic liquids (ILs) by Wilkes in 1992 has opened a new field of interest within the advanced multifunctional materials community. During the last 20 years, more focus has been paid to ILs because of their novel and adjustable physical and chemical features. [ 1 ] ILs... |
10. 1002/advs. 202202278 | 2,022 | Advanced Science | Emerging Magnetic Fabrication Technologies Provide Controllable Hierarchically‐Structured Biomaterials and Stimulus Response for Biomedical Applications | Abstract Multifunctional nanocomposites which exhibit well‐defined physical properties and encode spatiotemporally‐controlled responses are emerging as components for advanced responsive systems. For biomedical applications magnetic nanocomposite materials have attracted significant attention due to their ability to re... | 1 Introduction Researchers working across multiple fields are currently pursuing multifunctional nanocomposite systems that can provide well‐defined reproducible responses in both spatial and temporal domains for biomedical applications, such as remotely controlled mechano‐transduction for precise tuning of cellular pr... |
10. 1002/advs. 202202282 | 2,022 | Advanced Science | A Uterus‐Inspired Niche Drives Blastocyst Development to the Early Organogenesis | Abstract The fundamental physical features such as the mechanical properties and microstructures of the uterus need to be considered when building in vitro culture platforms to mimic the uterus for embryo implantation and further development but have long been neglected. Here, a uterus‐inspired niche (UN) constructed b... | 1 Introduction The natural uterine architecture is a highly stratified structure composed of three layers. The top layer of the endometrium, surrounded by the myometrium and perimetrium layers, plays a crucial role in embryo attachment and invasion during implantation. [ 1 ] Trophectoderm (TE) cells of the blastocyst m... |
10. 1002/advs. 202202317 | 2,022 | Advanced Science | Endothelial‐Smooth Muscle Cell Interactions in a Shear‐Exposed Intimal Hyperplasia on‐a‐Dish Model to Evaluate Therapeutic Strategies | Abstract Intimal hyperplasia (IH) represents a major challenge following cardiovascular interventions. While mechanisms are poorly understood, the inefficient preventive methods incentivize the search for novel therapies. A vessel‐on‐a‐dish platform is presented, consisting of direct‐contact cocultures with human prima... | 1 Introduction Intimal hyperplasia (IH) induced stenosis remains a major clinical problem that affects the long‐term outcome of stents and vascular conduits. [ 1, 2, 3 ] IH is a remodeling of the vessel wall that results in the thickening of the intimal layer, eventually leading to stenosis. Although the use of drug‐el... |
10. 1002/advs. 202202638 | 2,022 | Advanced Science | Machine Learning Reveals a General Understanding of Printability in Formulations Based on Rheology Additives | Abstract Hydrogel ink formulations based on rheology additives are becoming increasingly popular as they enable 3‐dimensional (3D) printing of non‐printable but biologically relevant materials. Despite the widespread use, a generalized understanding of how these hydrogel formulations become printable is still missing, ... | 1 Introduction By introducing additive manufacturing technologies to the field of tissue engineering (TE), and in particular 3D bioprinting, a significant expansion in the scope and applicability of TE approaches was achieved. [ 1 ] The advancement of 3D bioprinting significantly depends on development in three critica... |
10. 1002/advs. 202202684 | 2,022 | Advanced Science | Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks | Abstract Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal–phenolic networks (MPNs), an emerging organic–inorganic hybrid ... | 1 Introduction Throughout human history, pathogenic microorganisms such as bacteria have always been an important factor in the morbidity and mortality of human beings. [ 1 ] The discovery of antibiotics has provided a proven way to prevent and combat these microorganisms. However, the abuse of antibiotics and inadequa... |
10. 1002/advs. 202202877 | 2,022 | Advanced Science | Efficient Myogenic/Adipogenic Transdifferentiation of Bovine Fibroblasts in a 3D Bioprinting System for Steak‐Type Cultured Meat Production | Abstract The interest in cultured meat is increasing because of the problems with conventional livestock industry. Recently, many studies related to cultured meat have been conducted, but producing large‐sized cultured meat remains a challenge. It is aimed to introduce 3D bioprinting for producing large cell aggregates... | 1 Introduction The conventional livestock industry accounts for more than 18% of the greenhouse gas emissions that affect global climate change and is associated with various problems, such as environmental pollution, diseases, and animal ethics issues. [ 1, 2, 3 ] Moreover, according to the Food and Agriculture Organi... |
10. 1002/advs. 202203096 | 2,022 | Advanced Science | Structural Color Medical Patch with Surface Dual‐Properties of Wet Bioadhesion and Slipperiness | Abstract Developing a self‐reporting bioadhesive patch that has strong adhesion to the wet tissues and meanwhile can avoid adhering to the adjacent tissues is a current research difficulty and challenge. In this paper, inspired by the wet adhesion of spider web, slippery surface of Nepenthes, and structural color pheno... | 1 Introduction Tissue defects caused by trauma and chronic diseases affect tens of millions of people every year worldwide. [ 1 ] Surgical sutures are widely used to seal and repair tissues, but they suffer from several inherent drawbacks as they are time‐consuming, require complex operation, and pose a risk of inducti... |
10. 1002/advs. 202203183 | 2,022 | Advanced Science | Crystal Growth of 3D Poly( | Abstract Extrusion additive manufacturing is widely used to fabricate polymer‐based 3D bone scaffolds. However, the insight views of crystal growths, scaffold features and eventually cell‐scaffold interactions are still unknown. In this work, melt and solvent extrusion additive manufacturing techniques are used to prod... | 1 Introduction Tissue engineering combining additive manufacturing (AM), biomaterials, biomolecules, and cells has emerged as a promising strategy in the field of bone repair and extrusion‐based 3D printing is the most commonly used approach to fabricate customized and porous bone constructs using natural and synthetic... |
10. 1002/advs. 202203388 | 2,022 | Advanced Science | Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues | Abstract Coronavirus disease 2019 continues to spread worldwide. Given the urgent need for effective treatments, many clinical trials are ongoing through repurposing approved drugs. However, clinical data regarding the cardiotoxicity of these drugs are limited. Human pluripotent stem cell‐derived cardiomyocytes (hCMs) ... | 1 Introduction The coronavirus disease 2019 (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to spread worldwide. As of 31 May 2022, the World Health Organization statistics show over 526 million confirmed COVID‐19 cases, with over 6 million deaths. Drug repurposing r... |
10. 1002/advs. 202203557 | 2,022 | Advanced Science | Ti | Abstract Organoids have certain cellular composition and physiological features in common with real organs, making them promising models of organ formation, function, and diseases. However, Matrigel, the commonly used animal‐derived matrices in which they are developed, has limitations in mechanical adjustability and p... | 1 Introduction Hearing, balance, and acceleration are senses that are perceived by sensory structures within the inner ear. The epithelium of each of these structures is composed of mechanosensory hair cells and non‐sensory supporting cells. The auditory sensory epithelium in the mouse cochlea is made up of four rows o... |
10. 1002/advs. 202203587 | 2,022 | Advanced Science | Smart Internal Bio‐Glues | Abstract Although smart bio‐glues have been well documented, the development of internal bio‐glues for non‐invasive or minimally invasive surgery is still met with profound challenges such as safety risk and the lack of deep tissue penetration stimuli for internal usage. Herein, a series of smart internal bio‐glues are... | 1 Introduction Bio‐glues have attracted tremendous interest during recent decades for surgical applications owing to their promising physicochemical and biological properties, including strong bioadhesion, rapid hemostasis, low cost, and good biocompatibility. [ 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 ] Smart bio‐glu... |
10. 1002/advs. 202203734 | 2,022 | Advanced Science | Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation | Abstract Development of artificial biomaterials by mimicking extracellular matrix of bone tissue is a promising strategy for bone regeneration. Hydrogel has emerged as a type of viable substitute, but its inhomogeneous networks and weak mechanics greatly impede clinical applications. Here, a dual crosslinked gelling sy... | 1 Introduction Craniofacial bone defects resulting from trauma, infection, or tumor resection can result in loss of maxillofacial function and present numerous social, psychological, and emotional challenges, which impact patient quality of life significantly. Current clinical strategies for bone tissue transplantation... |
10. 1002/advs. 202203880 | 2,022 | Advanced Science | Micro‐Topographies Induce Epigenetic Reprogramming and Quiescence in Human Mesenchymal Stem Cells | Abstract Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression and cell identity, surface topography can control cell phenotype. This study provides fundamental insights into how surface topography influences nuclear morphology, histone m... | 1 Introduction Primary cells exposed to a standard in vitro culture environment can quickly lose morphological characteristics and phenotypic marker expression, as is well described for chondrocytes and tenocytes in Refs. [ 1, 2 ]. This phenomenon also occurs for multipotent cells, such as mesenchymal stem cells (MSCs)... |
10. 1002/advs. 202203948 | 2,022 | Advanced Science | Bubble‐Channeling Electrophoresis of Honeycomb‐Like Chitosan Composites | Abstract A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique. The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver. The formation of hydrogen bubbles during EPD renders a localized increase... | 1 Introduction Chitosan is a natural biopolymer known as a cationic polysaccharide and is recognized for its biocompatibility, antimicrobial ability, and biodegradability. [ 1 ] In the literature, chitosan and its composites have been studied in food packaging, drug release, chemical absorption, and wound dressing. [ 2... |
10. 1002/advs. 202204072 | 2,022 | Advanced Science | Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies | Abstract Two‐photon polymerization (TPP) has become a premier state‐of‐the‐art method for microscale fabrication of bespoke polymeric devices and surfaces. With applications ranging from the production of optical, drug delivery, tissue engineering, and microfluidic devices, TPP has grown immensely in the past two decad... | 1 Introduction Polymerization techniques are a staple of modern chemical production and they are applied extensively within industry for generating the items of everyday life. [ 1 ] While there are numerous polymerization methods—ranging from classical processes to more complex solid‐phase methods—this review will focu... |
10. 1002/advs. 202204234 | 2,022 | Advanced Science | Surface Functionalization of Hydroxyapatite Scaffolds with MgAlEu‐LDH Nanosheets for High‐Performance Bone Regeneration | Abstract Although artificial bone repair scaffolds, such as titanium alloy, bioactive glass, and hydroxyapatite (HAp), have been widely used for treatment of large‐size bone defects or serious bone destruction, they normally exhibit unsatisfied bone repair efficiency because of their weak osteogenic and angiogenesis pe... | 1 Introduction With the rapid aging of the population, bone defects and bone destruction caused by diseases (e. g. , osteoporosis, bacterial infections, and bone tumors) or accidental factors (e. g. , car accidents and trauma) are becoming increasingly common. [ 1, 2, 3 ] Under physiological condition, desired bone def... |
10. 1002/advs. 202204479 | 2,022 | Advanced Science | Curved Nanofiber Network Induces Cellular Bridge Formation to Promote Stem Cell Mechanotransduction | Abstract Remarkable exertions are directed to reveal and understand topographic cues that induce cell mechanical sensitive responses including lineage determination. Extracellular matrix (ECM) is the sophisticated ensemble of diverse factors offering the complicated cellular microenvironment to regulate cell behaviors.... | 1 Introduction The current studies realize both physical and biochemical factors acting on cell physiological and behavioral functions. Besides traditional chemical effects, novel biomaterials have been developed by mimicking the extracellular matrix (ECM) stiffness, [ 1 ] stress relaxation, [ 2 ] degradation, [ 3, 4 ]... |
10. 1002/advs. 202204502 | 2,022 | Advanced Science | Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions | Abstract Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to these bioelect... | 1 Introduction Bone is a hard mineralized tissue composed predominantly of inorganic hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) nanocrystals interspersed with various organic components including cells, collagen fibers, and various other extracellular matrix molecules. [ 1 ] In addition to providing structural support fo... |
10. 1002/advs. 202204509 | 2,022 | Advanced Science | Construction of a Band‐Aid Like Cardiac Patch for Myocardial Infarction with Controllable H | Abstract Excessive or persistent inflammation incites cardiomyocytes necrosis by generating reactive oxygen species in myocardial infarction (MI). Hydrogen sulfide (H 2 S), a gaseous signal molecule, can quickly permeate cells and tissues, growing concerned for its cardioprotective effects. However, short resident time... | 1 Introduction Myocardial infarction (MI) is the most common cause of heart failure (HF). It is always caused by prolonged restriction of blood flow to myocardium and can lead to necrosis of cardiomyocytes. [ 1, 2 ] Currently, strategy for HF treatment has changed from short‐term correction of hemodynamic parameters to... |
10. 1002/advs. 202204535 | 2,022 | Advanced Science | Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality | Abstract Bone implant‐associated infections induced by bacteria frequently result in repair failure and threaten the health of patients. Although black phosphorus (BP) material with superior photothermal conversion ability is booming in the treatment of bone disease, the development of BP‐based bone scaffolds with exce... | 1 Introduction Implant‐associated infections remain a serious problem in bone defect therapy and frequently result in repair failure, potentially threatening the health of patients. [ 1, 2 ] Recently, implanted scaffolds loaded with various antibiotics, [ 3, 4 ] such as ciprofloxacin and gentamicin, or antimicrobial na... |
10. 1002/advs. 202204553 | 2,022 | Advanced Science | Structural‐Functional Pluralistic Modification of Silk Fibroin via MOF Bridging for Advanced Wound Care | Abstract Silk fibroin (SF) is widely used to fabricate biomaterials for skin related wound caring or monitoring, and its hydrogel state are preferred for their adaptability and easy to use. However, in–depth development of SF hydrogel is restricted by their limited mechanical strength, increased risk of infection, and ... | 1 Introduction As a natural biopolymer with a long history of and great applied energy, silk fibroin (SF) is actively used in the development of a variety of medical materials, especially in the area of skin health maintenance and injury care. [ 1 ] SF wound dressings or wearables, prepared by processes like spinning a... |
10. 1002/advs. 202204594 | 2,023 | Advanced Science | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction | Abstract The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell c... | 1 Introduction The extracellular matrix (ECM), a complex, dynamic, and crosslinked meshwork with tethered biomolecules, is fundamental to the form and function of tissues and organs. It offers crucial physical support for the cells and generates essential biochemical and biomechanical signals required for tissue develo... |
10. 1002/advs. 202204609 | 2,022 | Advanced Science | Aqueous Two‐Phase Enabled Low Viscosity 3D (LoV3D) Bioprinting of Living Matter | Abstract Embedded 3D bioprinting has great value for the freeform fabrication of living matter. However, embedded 3D bioprinting is currently limited to highly viscous liquid baths or liquid‐like solid baths. In contrast, prior to crosslinking, most hydrogels are formulated as low‐viscosity solutions and are therefore ... | 1 Introduction 3D (bio)printing has emerged as a major driving force enabling the creation of viable, architected, clinically‐sized engineered tissues. [ 1 ] In the last decade, various printing techniques have been developed including stereolithography, drop‐on‐demand, and extrusion‐based deposition strategies. [ 2 ] ... |
10. 1002/advs. 202204681 | 2,023 | Advanced Science | Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications | Abstract Aerogel‐based biomaterials are increasingly being considered for biomedical applications due to their unique properties such as high porosity, hierarchical porous network, and large specific pore surface area. Depending on the pore size of the aerogel, biological effects such as cell adhesion, fluid absorption... | 1 Introduction Aerogels are a group of materials, composed of organic and inorganic building blocks with the unique properties of very low density, high porosity, open pores, and large pore surface area. [ 1 ] The porous structure of the aerogel is filled with air inside and consists of a highly crosslinked 3D solid ne... |
10. 1002/advs. 202204730 | 2,022 | Advanced Science | Light‐Fueled Hydrogel Actuators with Controlled Deformation and Photocatalytic Activity | Abstract Hydrogel actuators have shown great promise in underwater robotic applications as they can generate controllable shape transformations upon stimulation due to their ability to absorb and release water reversibly. Herein, a photoresponsive anisotropic hydrogel actuator is developed from poly(N‐isopropylacrylami... | 1 Introduction Bio‐inspired soft actuators that convert the energy received from external stimuli, such as heat or light, into mechanical work through flexible and complex shape‐change and motion have been the subject of extensive studies in the past decade. [ 1, 2, 3, 4, 5, 6 ] Biomimetic shape‐changes of soft actuato... |
10. 1002/advs. 202204786 | 2,022 | Advanced Science | Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures | Abstract The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of treatments based on WJ‐MSCs. Exploration of WJ‐MSC heterogeneity with multimodal single‐cell technologies will aid in establishing accurate ... | 1 Introduction Mesenchymal stem cells (MSCs) are multipotent cells with the ability to self‐renew and are being studied extensively as a cell therapy. [ 1 ] Wharton's jelly MSCs (WJ‐MSCs) have gained widespread favor over the last few years owing to their inherent advantages over MSCs from other sources, such as faster... |
10. 1002/advs. 202204848 | 2,022 | Advanced Science | Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications | Abstract This review addresses the latest advancements in the integration of aggregation‐induced emission (AIE) materials with polymer electrospinning, to accomplish fine‐scale electrospun fibers with tunable photophysical and photochemical properties. Micro‐ and nanoscale fibers augmented with AIE dyes (termed AIEgens... | 1 Background Luminescence is defined as “the emission of electromagnetic radiation (light) from a material that does not result from heating. ” The kind of energy that causes luminescence determines the distinct types, such as photoluminescence, cathodoluminescence, chemiluminescence, electroluminescence, mechanolumine... |
10. 1002/advs. 202204853 | 2,022 | Advanced Science | Anisotropic Microgels by Supramolecular Assembly and Precipitation Polymerization of Pyrazole‐Modified Monomers | Abstract Soft colloidal macromolecular structures with programmable chemical functionalities, size, and shape are important building blocks for the fabrication of catalyst systems and adaptive biomaterials for tissue engineering. However, the development of the easy upscalable and template‐free synthesis methods to obt... | 1 Introduction Colloidal nano‐ and microgels are most versatile colloidal building blocks for the design of stimuli‐responsive soft materials, [ 1 ] which have important applications in catalysis, [ 2, 3, 4 ] delivery of active molecules, [ 5, 6, 7 ] photonics, [ 8 ] and biomaterials. [ 9, 10 ] Their versatility stems ... |
10. 1002/advs. 202205041 | 2,022 | Advanced Science | A 3D‐Bioprinted Functional Module Based on Decellularized Extracellular Matrix Bioink for Periodontal Regeneration | Abstract Poor fiber orientation and mismatched bone–ligament interface fusion have plagued the regeneration of periodontal defects by cell‐based scaffolds. A 3D bioprinted biomimetic periodontal module is designed with high architectural integrity using a methacrylate gelatin/decellularized extracellular matrix (GelMA/... | 1 Introduction Periodontal disease, characterized by progressive alveolar bone destruction and loss of periodontium, is the leading cause of tooth loss in adults worldwide. [ 1 ] The ultimate goal of periodontal treatment is to regenerate tooth‐supporting tissue and form new attachments. Techniques such as bone graftin... |
10. 1002/advs. 202205059 | 2,023 | Advanced Science | Regeneration of Humeral Head Using a 3D Bioprinted Anisotropic Scaffold with Dual Modulation of Endochondral Ossification | Abstract Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers a potential treatment alternative for advanced osteoarthritis. However, to date, no significant progress is made in the regeneration of large biological joints. In the current stud... | 1 Introduction Osteoarthritis is a degenerative joint disease characterized by progressive loss of articular cartilage in synovial joints and affects millions of people worldwide. [ 1 ] To date, surgical replacement of a diseased joint arthroplasty with a synthetic prosthesis is the only available alternative to restor... |
10. 1002/advs. 202205292 | 2,023 | Advanced Science | Synthesis and Functionalization of Graphene Materials for Biomedical Applications: Recent Advances, Challenges, and Perspectives | Abstract Since its discovery in 2004, graphene is increasingly applied in various fields owing to its unique properties. Graphene application in the biomedical domain is promising and intriguing as an emerging 2D material with a high surface area, good mechanical properties, and unrivalled electronic and physical prope... | 1 Introduction Graphene is a single or few atoms thick sheet of sp 2 ‐bonded carbon atoms in a closely packed honeycomb 2D lattice. Naked graphene materials, including pristine graphene (p‐G), graphene oxide (GO), and reduced graphene oxide (rGO), were reported to obtain unique properties such as large surface area, [ ... |
10. 1002/advs. 202205302 | 2,023 | Advanced Science | From Free‐Radical to Radical‐Free: A Paradigm Shift in Light‐Mediated Biofabrication | Abstract In recent years, the development of novel photocrosslinking strategies and photoactivatable materials has stimulated widespread use of light‐mediated biofabrication techniques. However, despite great progress toward more efficient and biocompatible photochemical strategies, current photoresins still rely on ph... | 1 Introduction Light can serve as a remote, contactless trigger to drive a wide range of photochemical reactions. In tissue engineering, this powerful tool is used to form or break chemical bonds, [ 1, 2 ] playing an increasingly important role in the field of 3D bioprinting. [ 3, 4 ] Photoactivated materials have been... |
10. 1002/advs. 202205381 | 2,023 | Advanced Science | Engineering Multi‐Scale Organization for Biotic and Organic Abiotic Electroactive Systems | Abstract Multi‐scale organization of molecular and living components is one of the most critical parameters that regulate charge transport in electroactive systems—whether abiotic, biotic, or hybrid interfaces. In this article, an overview of the current state‐of‐the‐art for controlling molecular order, nanoscale assem... | 1 Introduction Electroactive organic materials, including synthetic polymers/ biomolecule‐based materials and their related devices, have emerged as key functional components of bioelectronic technologies over the past decades. [ 1, 2, 3, 4, 5, 6, 7 ] The conduction mechanisms of these organic materials can involve thr... |
10. 1002/advs. 202205487 | 2,023 | Advanced Science | Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli‐Responsive Cell‐Adhesive Micromaterials | Abstract Engineered living microtissues such as cellular spheroids and organoids have enormous potential for the study and regeneration of tissues and organs. Microtissues are typically engineered via self‐assembly of adherent cells into cellular spheroids, which are characterized by little to no cell–material interact... | 1 Introduction 3D cell cultures have the potential to closely emulate the architecture and function of our native tissues. [ 1 ] Material‐free microtissues in the form of cellular spheroids or organoids are considered the most biomimetic 3D culture models with myriad applications including disease modeling, [ 2 ] drug ... |
10. 1002/advs. 202205713 | 2,023 | Advanced Science | Small Molecule‐Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids | Abstract Deoxyribonucleic acid (DNA) hydrogels are a unique class of programmable, biocompatible materials able to respond to complex stimuli, making them valuable in drug delivery, analyte detection, cell growth, and shape‐memory materials. However, unmodified DNA hydrogels in the literature are very soft, rarely reac... | 1 Introduction Combining the processability of solids with the diffusion‐enabled reactions of liquids, hydrogels have generated considerable interest for their use in drug delivery, soft‐robotics, analyte detection, cell‐growth, and smart materials. [ 1 ] Of these, nucleic acid hydrogels—hydrogels formed by supramolecu... |
10. 1002/advs. 202205803 | 2,023 | Advanced Science | Current State of Cold Atmospheric Plasma and Cancer‐Immunity Cycle: Therapeutic Relevance and Overcoming Clinical Limitations Using Hydrogels | Abstract Cold atmospheric plasma (CAP) is a partially ionized gas that gains attention as a well‐tolerated cancer treatment that can enhance anti‐tumor immune responses, which are important for durable therapeutic effects. This review offers a comprehensive and critical summary on the current understanding of mechanism... | 1 Background Cold atmospheric plasma (CAP) is a partially ionized gas that represents a promising tool in biomedical research, with medically relevant applications ranging from wound healing and disinfection to cancer treatment. [ 1, 2 ] Its clinical utility lies in the fact that CAP is an adjustable, exogenous source ... |
10. 1002/advs. 202205942 | 2,023 | Advanced Science | Interfacial Engineering of PVDF‐TrFE toward Higher Piezoelectric, Ferroelectric, and Dielectric Performance for Sensing and Energy Harvesting Applications | Abstract The electrical properties of pristine fluoropolymers are inferior due to their low polar crystalline phase content and rigid dipoles that tend to retain their fixed moment and orientation. Several strategies, such as electrospinning, electrohydrodynamic pulling, and template‐assisted growing, have been proven ... | 1 Introduction As the current global energy crisis and chip shortage continues, the importance of switching to sustainable energy sources and developing alternative electronic materials is becoming more and more pronounced. Development of low‐power electronics in the last few decades has led to the possibility of using... |
10. 1002/advs. 202205997 | 2,023 | Advanced Science | Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment | Abstract High levels of reactive oxygen species (ROS) and inflammation create a complicated extrinsic neural environment that dominates the initial post‐injury period after spinal cord injury (SCI). The compensatory pathways between ROS and inflammation limited the efficacy of modulating the above single treatment regi... | 1 Introduction Spinal cord injury (SCI) occurs when an external physical impact (e. g. , car accidents, falls, sports injuries, or violent trauma) severely damages the spinal cord, disrupts the neuronal circuitry, and results in variable degrees of irreversible neurological dysfunction. [ 1 ] Initial mechanical trauma ... |
10. 1002/advs. 202206055 | 2,023 | Advanced Science | Lignin‐Based Materials for Additive Manufacturing: Chemistry, Processing, Structures, Properties, and Applications | Abstract The utilization of lignin, the most abundant aromatic biomass component, is at the forefront of sustainable engineering, energy, and environment research, where its abundance and low‐cost features enable widespread application. Constructing lignin into material parts with controlled and desired macro‐ and micr... | 1 Introduction The ubiquity of fossil fuel‐derived non‐biodegradable plastics has resulted in serious pollution to the environment, [ 1, 2, 3 ] and recent evidences indicate that the microplastics are even constantly inhaled and ingested by humans, causing a great threat to human health. [ 4, 5 ] Exiting the era of fos... |
10. 1002/advs. 202206144 | 2,023 | Advanced Science | Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression | Abstract Mitochondrial homeostasis is of great importance for cartilage integrity and associated with the progression of osteoarthritis (OA); however, the underlying mechanisms are unknown. This study aims to investigate the role of mitochondrial deacetylation reaction and investigate the mechanistic relationship OA de... | 1 Introduction Osteoarthritis (OA), the common form of arthritis, is rapidly becoming the most intractable chronic human health disorder, with a high socioeconomic cost and the leading cause of disability. It is estimated that OA affects over 500 million (7%) people globally. [ 1 ] Worth noting, that the prevalence of ... |
10. 1002/advs. 202206150 | 2,022 | Advanced Science | Erythrocyte‐Inspired Functional Materials for Biomedical Applications | Abstract Erythrocytes are the most abundant cells in the blood. As the results of long‐term natural selection, their specific biconcave discoid morphology and cellular composition are responsible for gaining excellent biological performance. Inspired by the intrinsic features of erythrocytes, various artificial biomate... | 1 Introduction Erythrocytes are the most abundant cells in the blood with optimized biological performances. They possess complex functionality attributing to unique biconcave discoid morphology, cellular components, and mechanical flexibility. [ 1, 2, 3 ] As the results of long‐term natural selection, mature erythrocy... |
10. 1002/advs. 202206153 | 2,023 | Advanced Science | Extracellular Matrix Rigidities Regulate the Tricarboxylic Acid Cycle and Antibiotic Resistance of Three‐Dimensionally Confined Bacterial Microcolonies | Abstract As a major cause of clinical chronic infection, microbial biofilms/microcolonies in host tissues essentially live in 3D‐constrained microenvironments, which potentially modulate their spatial self‐organization and morphodynamics. However, it still remains unclear whether and how mechanical cues of 3D confined ... | 1 Introduction Microorganisms that are ubiquitous on earth, often colonize as a community, that is, biofilms, both in the host and in the external environment. [ 1, 2 ] The formation of bacterial biofilm in host tissues is a serious threat to cause chronic infections in patients. [ 3 ] In fact, ≈80% of microbial infect... |
10. 1002/advs. 202206154 | 2,023 | Advanced Science | Flourishing Antibacterial Strategies for Osteomyelitis Therapy | Abstract Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis is one of the refractory diseases in orthopedics. Currently, anti‐infective therapy is the primary modality for osteomyelitis therapy... | 1 Introduction Osteomyelitis is a common orthopedic disease caused by bone tissue infection with pathogenic microorganisms. [ 1 ] It is generally classified into acute osteomyelitis and chronic osteomyelitis. [ 2 ] Approximately 10%–30% of acute osteomyelitis cases progress to chronic osteomyelitis. [ 3 ] According to ... |
10. 1002/advs. 202206195 | 2,023 | Advanced Science | A 3D Tumor‐Mimicking In Vitro Drug Release Model of Locoregional Chemoembolization Using Deep Learning‐Based Quantitative Analyses | Abstract Primary liver cancer, with the predominant form as hepatocellular carcinoma (HCC), remains a worldwide health problem due to its aggressive and lethal nature. Transarterial chemoembolization, the first‐line treatment option of unresectable HCC that employs drug‐loaded embolic agents to occlude tumor‐feeding ar... | 1 Introduction Primary liver cancer, the third lethal cancer that annually causes over 830 000 deaths worldwide, remains a severe health challenge with continuously increasing incidence and mortality. [ 1, 2 ] Hepatocellular carcinoma (HCC), the predominant liver cancer form accounting for 90% of the cases, usually sho... |
10. 1002/advs. 202206242 | 2,023 | Advanced Science | One‐Step Soaking Strategy toward Anti‐Swelling Hydrogels with a Stiff “Armor” | Abstract Double‐network (DN) hydrogels consisting of noncovalent interacting networks are highly desired due to their well‐controlled compositions and environmental friendliness, but the low water resistance always impairs their mechanical strength. Here, an anti‐swelling hydrogel possessing the core/shell architecture... | 1 Introduction Hydrogels, three‐dimensional (3D) polymeric network systems with similar physical properties to natural tissue, have been considered to be one of the best candidates as “soft and wet” materials for wide applications in biomedical fields, such as drug delivery, [ 1, 2, 3 ] tissue engineering [ 4, 5, 6, 7 ... |
10. 1002/advs. 202206264 | 2,023 | Advanced Science | Electric‐Field‐Driven Printed 3D Highly Ordered Microstructure with Cell Feature Size Promotes the Maturation of Engineered Cardiac Tissues | Abstract Engineered cardiac tissues (ECTs) derived from human induced pluripotent stem cells (hiPSCs) are viable alternatives for cardiac repair, patient‐specific disease modeling, and drug discovery. However, the immature state of ECTs limits their clinical utility. The microenvironment fabricated using 3D scaffolds c... | 1 Introduction Cardiovascular disease continues to be a major cause of morbidity and mortality worldwide. [ 1 ] However, donor organs are in short supply and the adult myocardium has a limited regenerative capacity. Cell therapy and cardiac tissue engineering are viable solutions to support the regeneration of cardiac ... |
10. 1002/advs. 202206433 | 2,023 | Advanced Science | Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs | Abstract Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one‐step introduction of diacylation linkers and azide groups on the 2′‐OH of RNA is advance. Selected from eight phosphine reagents, it is found that 2‐(diphenylphosphino)ethylamine has excellent... | 1 Introduction RNAs play key roles in biological processes including gene expression, transcript splicing, messenger transcription, and translocation, as well as catalysis. [ 1 ] Recent studies have pointed out other applications and properties of RNA, including RNA epigenetics, [ 2 ] post‐transcription modifications, ... |
10. 1002/advs. 202206450 | 2,023 | Advanced Science | A Mechanically Reinforced Super Bone Glue Makes a Leap in Hard Tissue Strong Adhesion and Augmented Bone Regeneration | Abstract Existing bone tissue engineering strategies aim to achieve minimize surgical trauma, stabilize the injured area, and establish a dynamic osteogenic microenvironment. The cutting‐edge bone glue developed in this study satisfies these criteria. Inspired by the excellent adhesive properties of mussels, herein, a ... | 1 Introduction Treating bone fractures caused by trauma, tumors, and orthopedic surgery remains one of the most common clinical challenges; it has impacted the health of tens of millions of people worldwide. [ 1 ] Although traditional technologies, such as plates, screws, and pins, are commonly adopted in the clinical ... |
10. 1002/advs. 202206602 | 2,023 | Advanced Science | Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections | Abstract Owing to the increase in multidrug‐resistant bacterial isolates in hospitals globally and the lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have increased substantially. There is thus an urgent need to develop new antimicrobial drugs and their related formulations. In ... | 1 Introduction The discovery of penicillin in the 20th century provided a transformative advantage in the fight against bacterial infections. However, bacterial evolutions resulting from the ill‐advised high‐dose use of antibiotics has led to antibiotic resistance. In 2019, three bacterial infection syndromes (respirat... |
10. 1002/advs. 202206616 | 2,023 | Advanced Science | From Chitosan to Chitin: Bio‐Inspired Thin Films for Passive Daytime Radiative Cooling | Abstract Passive radiative daytime cooling is an emerging technology contributing to carbon‐neutral heat management. Optically engineered materials with distinct absorption and emission properties in the solar and mid‐infrared range are at the heart of this technology. Owing to their low emissive power of about 100 W m... | 1 Introduction With the prospects of global warming, the demand for cooling applications is expected to increase in the future. In classical active cooling technologies like air conditioning, the heat is spatially displaced but remains in close vicinity. Furthermore, the AC unit releases excess waste heat into the envi... |
10. 1002/advs. 202206757 | 2,023 | Advanced Science | Lysine 68 Methylation‐Dependent SOX9 Stability Control Modulates Chondrogenic Differentiation in Dental Pulp Stem Cells | Abstract Dental pulp stem cells (DPSCs), characterized by easy availability, multi‐lineage differentiation ability, and high proliferation ability, are ideal seed cells for cartilage tissue engineering. However, the epigenetic mechanism underlying chondrogenesis in DPSCs remains elusive. Herein, it is demonstrated that... | 1 Introduction Cartilage defects from trauma or degenerative pathology frequently associate with a disability, leading to debilitating joint pain, locking phenomena, and reduced or disturbed function. [ 1 ] Unfortunately, articular cartilage has a minimal ability for self‐repair, and its regeneration remains the greate... |
10. 1002/advs. 202206814 | 2,023 | Advanced Science | Material Stiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells | Abstract Stiffness is an important physical property of biomaterials that determines stem cell fate. Guiding stem cell differentiation via stiffness modulation has been considered in tissue engineering. However, the mechanism by which material stiffness regulates stem cell differentiation into the tendon lineage remain... | 1 Introduction The tendon is a fibrous connective tissue that connects muscle to bone and transmits mechanical forces between these two tissues. Owing to overuse, aging and trauma, the tendon is prone to acute injuries and progressive wear, resulting in the development of tendon diseases. Morphologically, these tendon ... |
10. 1002/advs. 202206865 | 2,023 | Advanced Science | Thermoresponsive Hydrogel‐Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria‐Infected Wounds | Abstract Photothermal therapy (PTT) has emerged as an attractive technique for the treatment of bacterial infections. However, the uncontrolled heat generation in conventional PTT inevitably causes thermal damages to healthy tissues and/or organs. It is thus essential to develop a smart and universal strategy to regula... | 1 Introduction Being one of the major threats to human health, bacterial infections have exerted a huge burden on individuals, the society and the economy. [ 1, 2, 3 ] Although the discovery of antibiotics provides human a powerful weapon to fight against bacteria, the misuse and overuse of antibiotics lead to the rapi... |
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