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10. 1002/advs. 202306577 | 2,024 | Advanced Science | Transplantation of Neural Stem Cells Loaded in an IGF‐1 Bioactive Supramolecular Nanofiber Hydrogel for the Effective Treatment of Spinal Cord Injury | Abstract Spinal cord injury (SCI) leads to massive cell death, disruption, and demyelination of axons, resulting in permanent motor and sensory dysfunctions. Stem cell transplantation is a promising therapy for SCI. However, owing to the poor microenvironment that develops following SCI, the bioactivities of these graf... | 1 Introduction Spinal cord injury (SCI) is caused by primary mechanical force on the spinal cord that results in permanent motor and sensory dysfunction. [ 1 ] In response to primary spinal cord damage, posttraumatic local inflammation is activated, leading to the overproduction of inflammatory cytokines, axonal inhibi... |
10. 1002/advs. 202306683 | 2,024 | Advanced Science | DeepFreeze 3D‐biofabrication for Bioengineering and Storage of Stem Cells in Thick and Large‐Scale Human Tissue Analogs | Abstract 3D bioprinting holds great promise for meeting the increasing need for transplantable tissues and organs. However, slow printing, interlayer mixing, and the extended exposure of cells to non‐physiological conditions in thick structures still hinder clinical applications. Here the DeepFreeze‐3D (DF‐3D) procedur... | 1 Introduction Bioengineering of tissues is a promising approach for the development of therapeutic solutions for a wide range of debilitating diseases, such as organ failure and tissue damage. The ultimate goal is to create human tissue analogs with architectural complexity. [ 1, 2, 3 ] However, significant challenges... |
10. 1002/advs. 202306727 | 2,023 | Advanced Science | In Vitro Models for Investigating Intestinal Host–Pathogen Interactions | Abstract Infectious diseases are increasingly recognized as a major threat worldwide due to the rise of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can adequately mimic in vivo gastrointestinal physiology are in high demand to elucidate mechanisms behind pathogen infectivity, and... | 1 Introduction The intestinal tract serves as an intricate ecosystem with vital complex functions. Comprising the small and large intestines, the organs are specialized in digestion, absorption of nutrients, regulation of immune responses, and maintenance of overall body homeostasis. The healthy intestine is a dynamic ... |
10. 1002/advs. 202306784 | 2,024 | Advanced Science | Seamless Integration of Conducting Hydrogels in Daily Life: From Preparation to Wearable Application | Abstract Conductive hydrogels (CHs) have received significant attention for use in wearable devices because they retain their softness and flexibility while maintaining high conductivity. CHs are well suited for applications in skin‐contact electronics and biomedical devices owing to their high biocompatibility and con... | 1 Introduction In recent years, significant advances have been made in the field of smart wearable devices, driven by advances in both material systems and device technology. One promising application of wearable devices is to detect fine changes in deformation induced by human motion and convert these changes into ele... |
10. 1002/advs. 202306830 | 2,023 | Advanced Science | Cell‐Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non‐/Out‐of‐Equilibrium Dynamic Systems | Abstract Living cells are complex, nonequilibrium supramolecular systems capable of independently and/or cooperatively integrating multiple bio‐supramolecules to execute intricate physiological functions that cannot be accomplished by individual biomolecules. These biological design strategies offer valuable insights f... | 1 Introduction Living cells are multicomponent, nonequilibrium supramolecular systems composed of a myriad of bio‐supramolecules, including proteins, (deoxy)ribonucleic acids (DNA/RNA), lipids, and metabolites. [ 1 ] Living cells can integrate multiple bio‐supramolecules independently and cooperatively to execute elabo... |
10. 1002/advs. 202306924 | 2,024 | Advanced Science | Matrix Metalloproteinase‐Responsive Hydrogel with On‐Demand Release of Phosphatidylserine Promotes Bone Regeneration Through Immunomodulation | Abstract Inflammation‐responsive hydrogels loaded with therapeutic factors are effective biomaterials for bone tissue engineering and regenerative medicine. In this study, a matrix metalloproteinase (MMP)‐responsive injectable hydrogel is constructed by integrating an MMP‐cleavable peptide (pp) into a covalent tetra‐ar... | 1 Introduction Critical‐sized bone defects caused by trauma, congenital, and oncological diseases affect millions of people physically and psychologically and pose a challenge for effective treatment. [ 1 ] When the extensive size of osseous defects surpasses their self‐healing capacity, the bone tissue fails to regene... |
10. 1002/advs. 202306961 | 2,024 | Advanced Science | Intersection of Immunity, Metabolism, and Muscle Regeneration in an Autoimmune‐Prone MRL Mouse Model | Abstract Due to the limited capacity of mammals to regenerate complex tissues, researchers have worked to understand the mechanisms of tissue regeneration in organisms that maintain that capacity. One example is the MRL/MpJ mouse strain with unique regenerative capacity in ear pinnae that is absent from other strains, ... | 1 Introduction Tissue regeneration is a complex biological process to repair and renew injured tissue by replacing it with functional tissue. This restoration can be either partial, resulting in the recovery of a portion of the original structure and function, or complete, reflecting the process seen during development... |
10. 1002/advs. 202307232 | 2,024 | Advanced Science | Design and Development of Transient Sensing Devices for Healthcare Applications | Abstract With the ever‐growing requirements in the healthcare sector aimed at personalized diagnostics and treatment, continuous and real‐time monitoring of relevant parameters is gaining significant traction. In many applications, health status monitoring may be carried out by dedicated wearable or implantable sensing... | 1 Introduction As we approach the new era of advanced technologies in healthcare, highly accurate, personalized, and real‐time monitoring of health parameters becomes increasingly important in diagnostic, as well as in therapeutic applications. [ 1, 2, 3 ] Therefore, there is an increasing demand for a new generation o... |
10. 1002/advs. 202307353 | 2,024 | Advanced Science | Paintable Decellularized‐ECM Hydrogel for Preventing Cardiac Tissue Damage | Abstract The tissue‐specific heart decellularized extracellular matrix (hdECM) demonstrates a variety of therapeutic advantages, including fibrosis reduction and angiogenesis. Consequently, recent research for myocardial infarction (MI) therapy has utilized hdECM with various delivery techniques, such as injection or p... | 1 Introduction The myocardial infarction (MI) is caused by a blockage in the coronary artery, which reduces blood supply to the heart muscle. This lack of oxygen leads to tissue necrosis and the loss of cardiomyocytes (CMs) due to a necrotic and apoptotic environment. [ 1, 2 ] MI results in maladaptive ventricular remo... |
10. 1002/advs. 202307404 | 2,024 | Advanced Science | Tough Hydrogels for Load‐Bearing Applications | Abstract Tough hydrogels have emerged as a promising class of materials to target load‐bearing applications, where the material has to resist multiple cycles of extreme mechanical impact. A variety of chemical interactions and network architectures are used to enhance the mechanical properties and fracture mechanics of... | 1 Motivation Hydrogels are cross‐linked, water‐based polymer networks with reversible swelling, tunable porosity, elasticity, toughness, stiffness, and flexibility. The global market for hydrogels was valued 25. 2 billion U. S. dollars in 2021 and is projected to reach 45. 2 billion U. S. dollars by 2030 with major pro... |
10. 1002/advs. 202307630 | 2,024 | Advanced Science | Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing | Abstract Regulation of excessive inflammation and impaired cell proliferation is crucial for healing diabetic wounds. Although plant‐to‐mammalian regulation offers effective approaches for chronic wound management, the development of a potent plant‐based therapeutic presents challenges. This study aims to validate the ... | 1 Introduction Diabetes is a chronic metabolic disorder affecting 536. 6 million people worldwide, and its prevalence is expected to increase to 783. 2 million by 2045. [ 1 ] About 25% of patients with diabetes experience delayed and non‐healing wounds, resulting in prolonged pain, reduced vitality, and even amputation... |
10. 1002/advs. 202307746 | 2,023 | Advanced Science | Flexible Organic Photovoltaic‐Powered Hydrogel Bioelectronic Dressing With Biomimetic Electrical Stimulation for Healing Infected Diabetic Wounds | Abstract Electrical stimulation (ES) is proposed as a therapeutic solution for managing chronic wounds. However, its widespread clinical adoption is limited by the requirement of additional extracorporeal devices to power ES‐based wound dressings. In this study, a novel sandwich‐structured photovoltaic microcurrent hyd... | 1 Introduction Diabetic wounds represent a profoundly debilitating complication, afflicting ≈25% of individuals with type II diabetes during their lifetimes. [ 1 ] Unfortunately, statistics suggest that a lower limb is amputated every 30 s worldwide due to non‐healing diabetic wounds. [ 2 ] Despite the availability of ... |
10. 1002/advs. 202308051 | 2,024 | Advanced Science | Molecular Engineering of Electrosprayed Hydrogel Microspheres to Achieve Synergistic Anti‐Tumor Chemo‐Immunotherapy with ACEA Cargo | Abstract Molecular engineering of drug delivering platforms to provide collaborative biological effects with loaded drugs is of great medical significance. Herein, cannabinoid receptor 1 (CB1)‐ and reactive oxygen species (ROS)‐targeting electrosprayed microspheres (MSs) are fabricated by loading with the CB1 agonist a... | 1 Introduction Colorectal cancer is the third most commonly diagnosed cancer worldwide, and the second leading cause of cancer death. [ 1 ] The pathogenesis of colorectal cancer involves interactions between the tumor microenvironment (TME) and tumor cells. [ 2 ] Traditional treatment strategies such as surgery, chemot... |
10. 1002/advs. 202308241 | 2,024 | Advanced Science | Nanotherapeutics for Alleviating Anesthesia‐Associated Complications | Abstract Current management of anesthesia‐associated complications falls short in terms of both efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination of the ex... | 1 Introduction Medieval surgical procedures conducted without anesthesia were characterized by extreme brutality. It was not until 1846 when dentist William T. G. Morton successfully demonstrated the first public general anesthesia with inhaled ether that brought humankind to the dawn of painless surgery. [ 1 ] Over a ... |
10. 1002/advs. 202308381 | 2,024 | Advanced Science | Clay Sculpture‐Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific‐Shaped Tissue Vascularization and Regeneration | Abstract 3D bioprinting techniques have enabled the fabrication of irregular large‐sized tissue engineering scaffolds. However, complicated customized designs increase the medical burden. Meanwhile, the integrated printing process hinders the cellular uniform distribution and local angiogenesis. A novel approach is int... | 1 Introduction Tissue engineering and regenerative medicine are advancing fields aiming to create in vitro tissue‐engineered grafts for in vivo tissue repair. [ 1, 2 ] However, large in vitro grafts often suffer from an inadequate nutrient supply and necrosis due to poor vascularization. [ 3, 4 ] Microtissue assembly m... |
10. 1002/advs. 202308396 | 2,024 | Advanced Science | Acoustic Cell Patterning for Structured Cell‐Laden Hydrogel Fibers/Tubules | Abstract Cell‐laden hydrogel fibers/tubules are one of the fundamentals of tissue engineering. They have been proven as a promising method for constructing biomimetic tissues, such as muscle fibers, nerve conduits, tendon and vessels, etc. However, current hydrogel fiber/tubule production methods have limitations in or... | 1 Introduction Bio‐fabrication seeks to create synthetic biological substitutes to replicate the structural and physicochemical features of natural tissues. This endeavor is important in various fields, such as food production, [ 1 ] regenerative medicine [ 2 ] and drug discovery. [ 3 ] Consequently, the ability to pro... |
10. 1002/advs. 202308590 | 2,024 | Advanced Science | Puerarin‐Loaded Electrospun Patches with Anti‐Inflammatory and Pro‐Collagen Synthesis Properties for Pelvic Floor Reconstruction | Abstract Pelvic organ prolapse (POP) is one of the most common pelvic floor dysfunction disorders worldwide. The weakening of pelvic connective tissues initiated by excessive collagen degradation is a leading cause of POP. However, the patches currently used in the clinic trigger an unfavorable inflammatory response, w... | 1 Introduction Pelvic organ prolapse (POP) is a common urogynecological disorder that affects ≈25% of women across all age groups. [ 1 ] The main symptoms usually involve multiple organs, including urinary incontinence, vaginal bulge, fecal incontinence, and sexual dysfunction. With the aging trend of the global popula... |
10. 1002/advs. 202308635 | 2,024 | Advanced Science | Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries | Abstract Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such as glaucoma, non‐arteritic anterior ischemic optic neuropathy, traumatic optic neuropathy, and Leber hereditary optic neuropathy, among others. This unders... | 1 Introduction Oxidative damage is implicated in various pathological conditions including tissue degeneration, inflammation, and aging. In the field of tissue engineering, researchers strive to develop innovative strategies to regenerate or repair damaged tissues. This involves the utilization of biomaterials, cells, ... |
10. 1002/advs. 202308701 | 2,024 | Advanced Science | Framework Nucleic Acids‐Based VEGF Signaling Activating System for Angiogenesis: A Dual Stimulation Strategy | Abstract Angiogenesis is crucial for tissue engineering, wound healing, and regenerative medicine. Nanomaterials constructed based on specific goals can be employed to activate endogenous growth factor‐related signaling. In this study, based on the conventional single‐stranded DNA self‐assembly into tetrahedral framewo... | 1 Introduction Vascularization plays an important role in tissue engineering, wound healing, and regenerative medicine. Tissue engineering primarily involves developing a 3D composite of cells and biomaterials; thus, the morphology, structure, and function of damaged tissues can be reconstructed to realize permanent re... |
10. 1002/advs. 202309306 | 2,024 | Advanced Science | Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy | Abstract Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental nerve defects through autologous nerve transplantation often encounters challenges such as axonal mismatch and suboptimal functional recovery. These issues may stem from the lim... | 1 Introduction Peripheral nerve injury (PNI) is frequently instigated by momentous public health crises, such as traffic collisions, earthquakes, and explosions, and is accompanied by impaired limb function. [ 1, 2 ] PNI can culminate in an incomplete or complete loss of sensory, motor, and autonomic functions, severel... |
10. 1002/advs. 202309491 | 2,024 | Advanced Science | High‐Performance Hydrogel‐Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration | Abstract The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired by the discovery that the endoplasmic reticulum (ER) is in a state of excessive stress and dysfunction under hyperglycemia, leading to osteogenic disorder, a nov... | 1 Introduction Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia. [ 1 ] According to reports from the International Diabetes Federation (IDF), the global prevalence of diabetes is estimated to exceed 10% by 2030. [ 2 ] Diabetic patients face an elevated risk of bone fracture and delayed bo... |
10. 1002/advs. 202309562 | 2,024 | Advanced Science | Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration | Abstract The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose viscoelasticity (e. g. , stress relaxation) during periodontitis or dental trauma, which disrupt cell–extracellular matrix (ECM) interactions ... | 1 Introduction Periodontal ligaments (PDLs) mechanically anchor teeth on the alveolar bone and transfer mechanical loads to adjacent bone. [ 1, 2 ] Due to the hierarchical structure and gradients at soft–hard tissue insertion sites, PDLs have a very high incidence of injury and are susceptible to pathological stimuli, ... |
10. 1002/advs. 202309993 | 2,024 | Advanced Science | Hierarchically Assembled Nanofiber Scaffolds with Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment | Abstract To address current challenges in effectively treating large skin defects caused by trauma in clinical medicine, the fabrication, and evaluation of a novel radially aligned nanofiber scaffold (RAS) with dual growth factor gradients is presented. These aligned nanofibers and the scaffold's spatial design provide... | 1 Introduction The prevalence of various acute and chronic skin wounds, including injuries from accidents, burns, electrical and chemical exposures, diabetic foot ulcers, and pressure sores, persist as challenges to dermatologic surgery. [ 1 ] The current clinic's wound management primarily focuses on debridement and i... |
10. 1002/advs. 202310141 | 2,024 | Advanced Science | Mechanical Field Guiding Structure Design Strategy for Meta‐Fiber Reinforced Hydrogel Composites by Deep Learning | Abstract Fiber‐reinforced hydrogel composites are widely employed in many engineering applications, such as drug release, and flexible electronics, with more flexible mechanical properties than pure hydrogel materials. Comparing to the hydrogel strengthened by continuous fiber, the meta‐fiber reinforced hydrogel provid... | 1 Introduction Hydrogel receives highly scientific attention in soft robotics, [ 1, 2 ] biomedical‐engineering, [ 3, 4, 5 ] and flexible electronics engineering, [ 6, 7 ] due to its high recoverability, good biocompatibility, and sensitivity to environmental stimulus. However, traditional hydrogels commonly show poor m... |
10. 1002/advs. 202310162 | 2,024 | Advanced Science | Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ | Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) is developed, where the first and second networks are formed by dynamic imine bonds and non‐dynamic photo‐c... | 1 Introduction Biomaterials are playing an increasingly important role in tissue engineering and implantable medical devices. [ 1 ] However, exogenous biomaterials may trigger a series of cellular and molecular events in the host immune system, leading to inflammatory responses and even rejection of medical devices. [ ... |
10. 1002/advs. 202370039 | 2,023 | Advanced Science | Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies (Adv. Sci. 7/2023) | Two‐Photon Polymerization In article number 2204072 by Andrew Kellett and co‐workers, a series of two‐photon printed microstructures used in optical, drug delivery, tissue engineering, and microfluidic devices are placed on the columns of the Giant‐s Causeway, which is a natural phenomenon of interlocking basalt column... | No full text available |
10. 1002/advs. 202400271 | 2,024 | Advanced Science | A Dynamic Ultrasound Phantom with Tissue‐Mimicking Mechanical and Acoustic Properties | Abstract Tissue‐mimicking phantoms are valuable tools that aid in improving the equipment and training available to medical professionals. However, current phantoms possess limited utility due to their inability to precisely simulate multiple physical properties simultaneously, which is crucial for achieving a system u... | 1 Introduction Human tissue phantoms are widely used for characterizing medical devices and advancing academic research. However, many phantoms do not accurately represent the complex, multi‐faceted properties of dynamic human tissues, making them unsuitable models when multiple assessment variables are present. [ 1, 2... |
10. 1002/advs. 202400517 | 2,024 | Advanced Science | Scaling up of a Self‐Confined Catalytic Hybridization Circuit for Robust microRNA Imaging | Abstract The precise regulation of cellular behaviors within a confined, crowded intracellular environment is highly amenable in diagnostics and therapeutics. While synthetic circuitry system through a concatenated chemical reaction network has rarely been reported to mimic dynamic self‐assembly system. Herein, a catal... | 1 Introduction As a basic construct of life, cell is orchestrated by various biomolecular self‐assembly circuitry that further forms complex molecule reaction networks. The cytoskeleton, for example, is an impressive biochemical circuitry network that, under a predefined space and time, controls the mechanical property... |
10. 1002/advs. 202400898 | 2,024 | Advanced Science | Advanced Multifunctional Hydrogels for Enhanced Wound Healing through Ultra‐Fast Selenol‐S | Abstract Fabrication of versatile hydrogels in a facile and effective manner represents a pivotal challenge in the field of biomaterials. Herein, a novel strategy is presented for preparing on‐demand degradable hydrogels with multilevel responsiveness. By employing selenol‐dichlorotetrazine nucleophilic aromatic substi... | 1 Introduction Hydrogels are 3D networks of hydrophilic polymers that can be physically or chemically crosslinked. [ 1 ] The unique tunable physical properties, intricate structure, and exceptional biocompatibility of these materials enable them to faithfully mimic tissue and cellular microenvironments, rendering them ... |
10. 1002/advs. 202400981 | 2,024 | Advanced Science | A Decade of Advanced Science | No abstract available | We are happy and proud to present you the anniversary issue celebrating 10 years of Advanced Science. Time seems to have flown since we came together at the MRS in Boston in 2014 for the launch ceremony. Having started as a tiny journal with a single issue with 5 papers published in 2014, we now look at an established ... |
10. 1002/advs. 202470124 | 2,024 | Advanced Science | Clay Sculpture‐Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific‐Shaped Tissue Vascularization and Regeneration (Adv. Sci. 21/2024) | 3D Bioprinting In article number 2308381, Zhenxing Wang, Jiaming Sun, and co‐worker introduce a novel approach to constructing sizable tissue engineering grafts using a hydrogel with 3D printing and adhesive capabilities, verifying its ability to build tissue engineering grafts in vivo. This novel strategy holds signif... | No full text available |
10. 1002/agm2. 12231 | 2,022 | Aging Medicine | Three Tiers to biological escape velocity: The quest to outwit aging | Abstract As longevity companies emerge with new products and the fields of anti‐aging research develop new cutting‐edge therapies, three distinct classes of longevity methodologies emerge. This discussion finds that there are three clear classes (Tiers) of longevity systems that are currently under development, and all... | 1 INTRODUCTION Evidence is growing that a range of techniques and therapies may alter the path of biological aging. Many drivers of the aging process are becoming understood, and therapies in the form of drugs, lifestyle changes, or other interventions are rapidly arriving. Tier 1 interventions such as staying fit, 1, ... |
10. 1002/aic. 16042 | 2,017 | Aiche Journal. American Institute of Chemical Engineers | Stem cell biomanufacturing under uncertainty: A case study in optimizing red blood cell production | As breakthrough cellular therapy discoveries are translated into reliable, commercializable applications, effective stem cell biomanufacturing requires systematically developing and optimizing bioprocess design and operation. This article proposes a rigorous computational framework for stem cell biomanufacturing under ... | Introduction Biomanufacturing process engineering is now at a stage where we can consider systematic production of cell therapies. 1, 2, 3, 4, 5, 6, 7 But stem cell biomanufacturing is a new industry with high upfront costs and long time scales to market, so commercializing therapies such as ex vivo red blood cell (RBC... |
10. 1002/aic. 17470 | 2,022 | AIChE journal. American Institute of Chemical Engineers | Surfactant Interactions and Solvent Phase Solubility Modulate Small Molecule Release from Emulsion Electrospun Fibers | Emulsion electrospinning provides a tunable system for the development of porous scaffolds for controlled, localized drug delivery in tissue engineering applications. This study aimed to elucidate the role of model drug interactions with emulsion chemistry on loading and release rates from fibers with controlled fiber ... | No full text available |
10. 1002/aisy. 201900126 | 2,022 | Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) | Automation of Controlled/Living Radical Polymerization | Controlled/living radical polymerization (CLRP) techniques are widely utilized to synthesize advanced and controlled synthetic polymers for chemical and biological applications. While automation has long stood as a high-throughput (HTP) research tool to increase productivity as well as synthetic/analytical reliability ... | 1. Introduction Automated processes have been used in the laboratory for many decades to increase productivity while improving synthetic/analytical reliability and precision. [ 1 ] In the pharmaceutical industry, for example, automation has significantly enabled high-throughput (HTP) tools for drug screening and the mo... |
10. 1002/ame2. 12067 | 2,019 | Animal Models and Experimental Medicine | Effect of the hyaluronic acid‐poloxamer hydrogel on skin‐wound healing: in vitro and in vivo studies | Abstract Background Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing. Metho... | 1 INTRODUCTION Skin‐wound healing is critical for successful outcomes of surgical and emergency medical procedures. 1, 2, 3, 4, 5, 6 Skin wounds can be created by surgery, scalds, burns, physical trauma or animal bites. 7, 8, 9, 10 Recent research related to skin‐wound healing has focused mainly on four aspects: (a) po... |
10. 1002/ame2. 12244 | 2,023 | Animal Models and Experimental Medicine | Cover Picture | The cover image is based on the article ‘Transcriptomic and proteomic studies of condylar ossification of the temporomandibular joint in porcine embryos’(Doi: 10. 1002/ame2. 12326 ) reported by Lei Xiang, Yongfeng Li, et. al. Transcriptome and proteomic analysis during the embryonic development of temporomandibular joi... | No full text available |
10. 1002/ame2. 12293 | 2,022 | Animal Models and Experimental Medicine | Evaluation of direct intramural injection to the bladder wall as a method for developing orthotopic tumor models | Abstract Background Bladder cancer poses a great burden on society and its high rate of recurrence and treatment failure necessitates use of appropriate animal models to study its pathogenesis and test novel treatments. Orthotopic models are superior to other types since they provide a normal microenvironment. Four met... | 1 INTRODUCTION Bladder cancer is the fourth most common cancer globally and the eighth cause of cancer death among men, leading to great morbidity. 1 Its high recurrence rate and high treatment failure rate, as well as the limited treatment options, necessitate better understanding of its molecular‐biology basis and pa... |
10. 1002/ame2. 12300 | 2,023 | Animal Models and Experimental Medicine | The bioelectrical properties of bone tissue | Abstract Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries, as well as improving the design and fabrication of scaffold implants for bone tissue engineering. The bioelectrical properties of bone tissue can be attributed to the interact... | 1 INTRODUCTION Bone is a highly‐vascularized, but hard and rigid tissue that serves to provide structural support, and protect vulnerable soft tissues and organs within the human body. 1 It can occur as either compact or cancellous (trabecular) forms. 2 For the purpose of this review, the soft vascular, hematopoietic a... |
10. 1002/ame2. 12326 | 2,023 | Animal Models and Experimental Medicine | Transcriptomic and proteomic studies of condylar ossification of the temporomandibular joint in porcine embryos | Abstract Background The ossification mechanism of the temporomandibular joint (TMJ) condyle remains unclear in human embryo. The size and structure of TMJ, shape of articular disc and the characteristics of omnivorous chewing in the pig are similar to those of humans. The pig is an ideal animal for studying the mechani... | 1 INTRODUCTION The temporomandibular joint (TMJ) is a synovial, double, and bicondylar joint, which is composed of mandibular condyle, articular disc, articular fossa, superior and inferior articular cavities and associated muscles and tendons. 1, 2 The mandibular condyle which is mainly formed by endochondral ossifica... |
10. 1002/ame2. 12334 | 2,023 | Animal Models and Experimental Medicine | Biology and function of pericytes in the vascular microcirculation | Abstract Pericytes are the main cellular components of tiny arteries and capillaries. Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines, thus affecting the contraction and relaxation of microvessels and playing an essential role in regulating vascular m... | 1 INTRODUCTION Pericytes were discovered by the French scientist Charles Benjamin Rouget in 1873, and were originally known as “Rouget's cells”. 1 They are candidates for regulating microcirculatory blood flow because they strategically cover 90% of the surface area of capillaries and can respond quickly to neuronal st... |
10. 1002/ame2. 12363 | 2,023 | Animal Models and Experimental Medicine | Neurotrophins and neural stem cells in posttraumatic brain injury repair | Abstract Traumatic brain injury (TBI) is the main cause of disability, mental health disorder, and even death, with its incidence and social costs rising steadily. Although different treatment strategies have been developed and tested to mitigate neurological decline, a definitive cure for these conditions remains elus... | 1 INTRODUCTION Traumatic brain injury (TBI) is a significant global public health concern, with an estimated annual incidence of at least 10 million cases resulting in hospitalization or death. 1 TBI is mainly caused by external mechanical forces, which leads to histopathological changes in the brain or brain dysfuncti... |
10. 1002/anbr. 202000057 | 2,021 | Advanced nanobiomed research | Bioinspired Polymeric High Aspect Ratio Particles with Asymmetric Janus Functionalities | Polymeric particles with intricate morphologies and properties have been developed based on bioinspired designs for applications in regenerative medicine, tissue engineering, and drug delivery. However, the fabrication of particles with asymmetric functionalities remains a challenge. Janus polymeric particles are an em... | No full text available |
10. 1002/anbr. 202100073 | 2,022 | Advanced nanobiomed research | (Bio)manufactured Solutions for Treatment of Bone Defects with Emphasis on US-FDA Regulatory Science Perspective | Bone defects, with second highest demand for surgeries around the globe, may lead to serious health issues and negatively influence patient lives. The advances in biomedical engineering and sciences have led to the development of several creative solutions for bone defect treatment. This review provides a brief summary... | No full text available |
10. 1002/anbr. 202100119 | 2,021 | Advanced nanobiomed research | Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective | Vocal folds, housed in the upper respiratory tract, are important to daily breathing, speech and swallowing functions. Irreversible changes to the vocal fold mucosae, such as scarring and atrophy, require a regenerative medicine approach to promote a controlled regrowth of the extracellular matrix (ECM)-rich mucosa. Va... | No full text available |
10. 1002/anbr. 202200022 | 2,022 | Advanced nanobiomed research | Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds | Photocrosslinked hydrogels, such as methacrylate-modified gelatin (gelMA) and hyaluronic acid (HAMA), are widely utilized as tissue engineering scaffolds and/or drug delivery vehicles, but lack a suitable means for non-invasive, longitudinal monitoring of surgical placement, biodegradation, and drug release. Therefore,... | No full text available |
10. 1002/anbr. 202200095 | 2,023 | Advanced nanobiomed research | Unraveling the Relevance of Tissue-Specific Decellularized Extracellular Matrix Hydrogels for Vocal Fold Regenerative Biomaterials: A Comprehensive Proteomic and In Vitro Study | Decellularized extracellular matrix (dECM) is a promising material for tissue engineering applications. Tissue-specific dECM is often seen as a favorable material that recapitulates a native-like microenvironment for cellular remodeling. However, the minute quantity of dECM derivable from small organs like the vocal fo... | No full text available |
10. 1002/anbr. 202300104 | 2,024 | Advanced nanobiomed research | Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold | Natural biomaterials are commonly used as tissue engineering scaffolds due to their biocompatibility and biodegradability. Plant-derived materials have also gained significant interest due to their abundance and as a sustainable resource. This study evaluates the corn-derived protein zein as a plant-derived substitute ... | 1. Introduction Tissue engineering approaches can utilize scaffolds to provide support for cells by enabling cells to adhere, grow, and deposit extracellular matrix. [ 1 ] Scaffolds composed of natural biomaterials, such as proteins and polysaccharides from plant and animal sources, are investigated due to advantages i... |
10. 1002/ange. 201508415 | 2,015 | Angewandte Chemie (Weinheim an Der Bergstrasse, Germany) | Silica Nanowires Templated by Amyloid‐like Fibrils | Abstract Many peptides self‐assemble to form amyloid fibrils. We previously explored the sequence propensity to form amyloid using variants of a designed peptide with sequence KFFEAAAKKFFE. These variant peptides form highly stable amyloid fibrils with varied lateral assembly and are ideal to template further assembly ... | Molecular self‐assembly occurs spontaneously when mole‐cules associate with each other to form three‐dimensional structures consisting of many weak and reversible interactions such as van der Waals forces, hydrogen bonds, and electrostatic and hydrophobic interactions. All these interactions are essential to maintain t... |
10. 1002/ange. 202107161 | 2,021 | Angewandte Chemie (Weinheim an Der Bergstrasse, Germany) | Using Stereochemistry to Control Mechanical Properties in Thiol–Yne Click‐Hydrogels | Abstract The stereochemistry of polymers has a profound impact on their mechanical properties. While this has been observed in thermoplastics, studies on how stereochemistry affects the bulk properties of swollen networks, such as hydrogels, are limited. Typically, changing the stiffness of a hydrogel is achieved at th... | Introduction The 3‐dimensional arrangement of bonds, or stereochemistry, dictates the function and behaviour of molecules spanning from biological systems to drugs to synthetic polymers. Stereochemistry is critical in the production of the basic building blocks of life. The chirality of deoxyribose dictates the backbon... |
10. 1002/anie. 201401043 | 2,014 | Angewandte Chemie (International Ed. in English) | Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles | Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization or cross-linking reactions and currently suffer from being toxic, weak, or inefficient within the wet conditions of the body. Herein, we demonstrate using Stöber silica or... | Stopping bleeding (hemostasis), preventing body fluid leakages, wound closing, and organ repair are everyday challenges in medical and surgical practice. [ 1 ] Sutures and staples are standard and efficient tools. Still, suturing can be demanding in inaccessible body regions or within minimally invasive surgery. Moreov... |
10. 1002/anie. 201403812 | 2,014 | Angewandte Chemie (International ed. in English) | Optical-Resolution Photoacoustic Microscopy for Volumetric and Spectral Analysis of Histological and Immunochemical Samples | Optical-resolution photoacoustic microscopy (OR-PAM) is an imaging modality with superb penetration depth and excellent absorption contrast. Here we demonstrate, for the first time, that this technique can advance quantitative analysis of conventional chromogenic histochemistry. Because OR-PAM can quantify the absorpti... | No full text available |
10. 1002/anie. 201408971 | 2,015 | Angewandte Chemie (International Ed. in English) | The Influence of Two-Dimensional Organization on Peptide Conformation | Molecular crowding plays a significant role in regulating molecular conformation in cellular environments. It is also likely to be important wherever high molecular densities are required, for example in surface-phase studies, in which molecular densities generally far exceed those observed in solution. Using on-surfac... | Molecular crowding plays an essential role in the assembly and stability of many macromolecular complexes, for example, α-synuclein fibrils[ 1 ] and the HIV-1 capsid protein. [ 2 ] Similarly, the activity of enzymes, such as superoxide dismutase for catalase, [ 3 ] is strongly affected by molecular crowding. A comprehe... |
10. 1002/anie. 201502287 | 2,015 | Angewandte Chemie (International ed. in English) | Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging | In this study we report the synthesis of a novel class of near-infrared fluorescent contrast agents that possess high-specificity targeting to cartilage inherent to the chemical structure of the fluorophore. After a single, low-dose intravenous injection and a clearance time of ≤ 4 h, these agents bind to all three maj... | No full text available |
10. 1002/anie. 201506262 | 2,015 | Angewandte Chemie (International Ed. in English) | Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer‐Associated Fibroblast Activation | Abstract A novel cleavable amphiphilic peptide (CAP) was designed to be specifically responsive to fibroblast activation protein‐α (FAP‐α), a protease specifically expressed on the surface of cancer‐associated fibroblasts. The CAP self‐assembled into fiber‐like nanostructures in solution, while the presence of hydropho... | Nanomaterial‐based drug delivery systems have long been seen as particularly promising for cancer therapy because of their great potential for improving drug specificity, biocompatibility, pharmacokinetic features, and antitumor efficacy. 1 However, for most particulate‐based drug carriers, the heterogeneity among tumo... |
10. 1002/anie. 201508415 | 2,015 | Angewandte Chemie (International Ed. in English) | Silica Nanowires Templated by Amyloid-like Fibrils | Many peptides self-assemble to form amyloid fibrils. We previously explored the sequence propensity to form amyloid using variants of a designed peptide with sequence KFFEAAAKKFFE. These variant peptides form highly stable amyloid fibrils with varied lateral assembly and are ideal to template further assembly of non-pr... | Molecular self-assembly occurs spontaneously when mole-cules associate with each other to form three-dimensional structures consisting of many weak and reversible interactions such as van der Waals forces, hydrogen bonds, and electrostatic and hydrophobic interactions. All these interactions are essential to maintain t... |
10. 1002/anie. 201509025 | 2,015 | Angewandte Chemie (International Ed. in English) | Plasmonic Surfaces for Cell Growth and Retrieval Triggered by Near‐Infrared Light | Abstract Methods for efficient detachment of cells avoiding damage are required in tissue engineering and regenerative medicine. We introduce a bottom–up approach to build plasmonic substrates using micellar block copolymer nanolithography to generate a 2D array of Au seeds, followed by chemical growth leading to aniso... | Controlled and non‐invasive cell harvesting from responsive surfaces devoted to cell culture is of high relevance for biomedical research, regenerative medicine, and tissue engineering. 1 The substrates should provide multivalency (be suitable for different cell types) and high biocompatibility, allowing surface biofun... |
10. 1002/anie. 201700153 | 2,017 | Angewandte Chemie (International Ed. in English) | Control of Nanoparticle Release Kinetics from 3D Printed Hydrogel Scaffolds | Abstract The convergence of biofabrication with nanotechnology is largely unexplored but enables geometrical control of cell‐biomaterial arrangement combined with controlled drug delivery and release. As a step towards integration of these two fields of research, this study demonstrates that modulation of electrostatic... | Additive manufacturing (AM), often referred to as 3D printing, exhibits great potential for tissue engineering and regenerative medicine, especially in biofabrication where cells and materials are processed simultaneously into composite structures with hierarchical organization. 1 A key challenge is the development of ... |
10. 1002/anie. 201701356 | 2,017 | Angewandte Chemie (International Ed. in English) | Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity | Abstract Oligonucleotide‐templated reactions are valuable tools for nucleic acid sensing both in vitro and in vivo. They are typically carried out under conditions that make any reaction in the absence of template highly unfavorable (most commonly by using a low concentration of reactants), which has a negative impact ... | Widely present in nature, most notably to catalyze phosphodiester bond formation in key biological processes including transcription and translation, oligonucleotide templated reactions (OTRs) are highly versatile and have been successfully applied to a broad range of chemistries. 1 This powerful concept allows unfavor... |
10. 1002/anie. 201704046 | 2,017 | Angewandte Chemie (International Ed. in English) | Strain Stiffening Hydrogels through Self‐Assembly and Covalent Fixation of Semi‐Flexible Fibers | Abstract Biomimetic, strain‐stiffening materials are reported, made through self‐assembly and covalent fixation of small building blocks to form fibrous hydrogels that are able to stiffen by an order of magnitude in response to applied stress. The gels consist of semi‐flexible rodlike micelles of bisurea bolaamphiphile... | Many natural soft tissues respond to small strains with a large change in mechanical properties. A particularly advantageous response of natural materials is to stiffen when exposed to small strains. This behavior can counteract large deformations, which otherwise might compromise their integrity. Such complex, non‐lin... |
10. 1002/anie. 201707321 | 2,017 | Angewandte Chemie (International Ed. in English) | Metallo‐Supramolecular Gels that are Photocleavable with Visible and Near‐Infrared Irradiation | Abstract A photolabile ruthenium‐based complex, [Ru(bpy) 2 (4AMP) 2 ](PF 6 ) 2, (4AMP=4‐(aminomethyl)pyridine) is incorporated into polyurea organo‐ and hydrogels via the reactive amine moieties on the photocleavable 4AMP ligands. While showing long‐term stability in the dark, cleavage of the pyridine–ruthenium bond up... | Functional polymers which can be photochemically manipulated by exogenous light have immense promise in materials science, with applications ranging from drug delivery to photolithography. 1 Photoresponsive polymers 2 offer localization, either via photo‐isomerization 3 or photo‐cleavage mechanisms. 4 Photoresponsive u... |
10. 1002/anie. 201708635 | 2,017 | Angewandte Chemie (International Ed. in English) | An Epitope‐Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell–Biomaterial Interactions | Abstract In this study, an epitope‐imprinting strategy was employed for the dynamic display of bioactive ligands on a material interface. An imprinted surface was initially designed to exhibit specific affinity towards a short peptide (i. e. , the epitope). This surface was subsequently used to anchor an epitope‐tagged... | Cellular processes are crucially dependent on dynamic receptor–ligand interactions occurring at the interface between the cell membrane and the extracellular matrix (ECM). 1 Changes in these interactions as a consequence of ECM remodeling give rise to specific cell‐signaling and intracellular cascades. These processes ... |
10. 1002/anie. 201709934 | 2,017 | Angewandte Chemie (International Ed. in English) | Unlocking the Potential of Poly( | Abstract Poly( ortho ester)s (POEs) are well‐known for their surface‐eroding properties and hence present unique opportunities for controlled‐release and tissue‐engineering applications. Their development and wide‐spread investigation has, however, been severely limited by challenging synthetic requirements that incorp... | The use of biodegradable polymers for controlled drug release and tissue engineering represents one of the most important advances in biomedicine. 1, 2, 3 An ideal material would display a surface erosion profile in which hydrolysis occurs faster than water ingress into the materials and results in sequential erosion o... |
10. 1002/anie. 201710272 | 2,018 | Angewandte Chemie (International Ed. in English) | Porous Polyelectrolytes: The Interplay of Charge and Pores for New Functionalities | Abstract The past decade has witnessed rapid advances in porous polyelectrolytes and there is tremendous interest in their synthesis as well as their applications in environmental, energy, biomedicine, and catalysis technologies. Research on porous polyelectrolytes is motivated by the flexible choice of functional orga... | 1 Introduction Porous polymers have been actively pursued to address today's challenges in areas such as energy technology, sustainable development, clean water, and healthy living. 1 They are an essential part of modern industry and daily life, for example, in soft sponges, fabrics, and filters/separators that supply ... |
10. 1002/anie. 201801001 | 2,018 | Angewandte Chemie (International Ed. in English) | Tunable Pentapeptide Self‐Assembled β‐Sheet Hydrogels | Abstract Oligopeptide‐based supramolecular hydrogels hold promise in a range of applications. The gelation of these systems is hard to control, with minor alterations in the peptide sequence significantly influencing the self‐assembly process. We explored three pentapeptide sequences with different charge distributions... | The self‐assembly of oligopeptide sequences into nanostructures holds promise for a range of applications in biomedicine, food science, cosmetics, and nanotechnology. 1, 2, 3 These materials can be readily synthesized, providing hydrogel systems with robust mechanical properties. 3 Experimental and computational approa... |
10. 1002/anie. 201808908 | 2,018 | Angewandte Chemie (International Ed. in English) | A Modular Approach to Sensitized Two‐Photon Patterning of Photodegradable Hydrogels | Abstract Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo‐induced degradation of such hydrogel systems is commonly based on the integratio... | Hydrogels, crosslinked highly hydrated polymer networks with engineerable properties, are currently utilized in various strategies for tissue engineering, regenerative medicine, and cell delivery, as they permit mimicking the physicochemical properties of the native extracellular matrix (ECM) of soft biological tissues... |
10. 1002/anie. 201814320 | 2,019 | Angewandte Chemie (International Ed. in English) | Metabolically Active, Fully Hydrolysable Polymersomes | Abstract The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegradable polymer... | Aliphatic polyesters can be biocompatible and biodegradable, and as such they are important materials for medical devices, tissue engineering, and in drug delivery. 1 Three FDA approved and widely applied hydrophobic polyesters are poly(ϵ‐caprolactone) (PCL), polylactide (PLA), and poly(lactic‐ co ‐glycolic acid) (PLGA... |
10. 1002/anie. 201905600 | 2,019 | Angewandte Chemie (International Ed. in English) | Beyond Charge Balance: Counter‐Cations in Polyoxometalate Chemistry | Abstract Polyoxometalates (POMs) are molecular metal‐oxide anions applied in energy conversion and storage, manipulation of biomolecules, catalysis, as well as materials design and assembly. Although often overlooked, the interplay of intrinsically anionic POMs with organic and inorganic cations is crucial to control P... | 1 Introduction: Fundamentals of POM–Cation Interactions 1. 1 Polyoxometalates Polyoxometalates (POMs) are molecular metal‐oxide anions that form by self‐assembly of reactive oxometalate precursors in aqueous or organic solution. 1 They are key intermediates in the reaction pathway from water‐soluble metal ions to insol... |
10. 1002/anie. 201907880 | 2,019 | Angewandte Chemie (International Ed. in English) | Design Parameters of Tissue‐Engineering Scaffolds at the Atomic Scale | Abstract Stem‐cell behavior is regulated by the material properties of the surrounding extracellular matrix, which has important implications for the design of tissue‐engineering scaffolds. However, our understanding of the material properties of stem‐cell scaffolds is limited to nanoscopic‐to‐macroscopic length scales... | Introduction Stem cells respond to their microenvironment, which provides critical cues for their migration, differentiation, and proliferation. 1, 2, 3, 4, 5 The regulatory interplay between stem cells and their native extracellular matrix has important implications for the design of biomimetic tissue‐engineering scaf... |
10. 1002/anie. 201910060 | 2,019 | Angewandte Chemie (International Ed. in English) | Orthogonal Nanoparticle Catalysis with Organogermanes | Abstract Although nanoparticles are widely used as catalysts, little is known about their potential ability to trigger privileged transformations as compared to homogeneous molecular or bulk heterogeneous catalysts. We herein demonstrate (and rationalize) that nanoparticles display orthogonal reactivity to molecular ca... | Introduction Over the past decade the nanotechnology industry has surged forward to reach a global market of greater than one trillion US dollars in 2018, 1 with diverse applications ranging from materials for solar cells, photonics, cosmetics or biomedical applications, such as drug delivery, tissue engineering, and c... |
10. 1002/anie. 201910634 | 2,020 | Angewandte Chemie (International Ed. in English) | It's in the Fine Print: Erasable Three‐Dimensional Laser‐Printed Micro‐ and Nanostructures | Abstract 3D printing, on all scales, is currently a vibrant topic in scientific and industrial research as it has enormous potential to radically change manufacturing. Owing to the inherent nature of the manufacturing process, 3D printed structures may require additional material to structurally support complex feature... | 1 Introduction Three‐dimensional (3D) printing is an additive manufacturing process developed in the early 1980s that translates a computer‐aided design into a physical object. 5 In recent years, 3D printing has attracted much interest in the industrial and scientific community as it offers enormous potential to radica... |
10. 1002/anie. 201911404 | 2,019 | Angewandte Chemie (International Ed. in English) | Self‐Assembling Supramolecular Hybrid Hydrogel Beads | Abstract With the goal of imposing shape and structure on supramolecular gels, we combine a low‐molecular‐weight gelator (LMWG) with the polymer gelator (PG) calcium alginate in a hybrid hydrogel. By imposing thermal and temporal control of the orthogonal gelation methods, the system either forms an extended interpenet... | Introduction Supramolecular hydrogels self‐assembled from low‐molecular‐weight gelator (LMWG) building blocks in water have seen rapid recent development. 1 A range of gels has been developed targeting high‐tech applications including regenerative medicine, wound healing, pharmaceutical formulation, optoelectronics, en... |
10. 1002/anie. 202006381 | 2,020 | Angewandte Chemie (International Ed. in English) | Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non‐Covalent Chemistries | Abstract Understanding cell/material interactions is essential to design functional cell‐responsive materials. While the scientific literature abounds with formulations of biomimetic materials, only a fraction of them focused on mechanisms of the molecular interactions between cells and material. To provide new knowled... | In a superb way, nature exploits multivalent non‐covalent interactions to build complex, dynamic, and functional structures. 1, 2 Mimicking the sophistication of natural systems represents an extremely challenging task for researchers, especially in the design of biomaterials. Utilizing the dynamics and modularity offe... |
10. 1002/anie. 202008471 | 2,020 | Angewandte Chemie (International Ed. in English) | Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications | Abstract We report on the directed postsynthetic functionalization of soft DNA nanocomposite materials with proteins. Using the example of the functionalization of silica nanoparticle‐modified DNA polymer materials with agonists or antagonists of the epidermal growth factor receptor EGFR cell membrane receptor, we demo... | DNA‐based hydrogels are on their way to becoming indispensable as a matrix for basic and applied biomedical research. 1 These materials may have the same general properties as corresponding synthetic polymer‐based hydrogels, such as high water content, biocompatibility and mechanical adaptability. However, they also po... |
10. 1002/anie. 202008681 | 2,020 | Angewandte Chemie (International Ed. in English) | Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments | Abstract The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer progression. In this paper, w... | Introduction Cancer cells invade into their surrounding healthy tissues by degrading their surrounding extracellular matrix (ECM) and secreting fresh ECM. [ 1, 2 ] The altered matrix microenvironment in turn deregulates the signaling within cancer cells, potentiating their invasion. [ 3, 4 ] A strong interdependency ex... |
10. 1002/anie. 202011592 | 2,020 | Angewandte Chemie (International Ed. in English) | Wavelength‐Gated Adaptation of Hydrogel Properties via Photo‐Dynamic Multivalency in Associative Star Polymers | Abstract Responsive materials, such as switchable hydrogels, have been largely engineered for maximum changes between two states. In contrast, adaptive systems target distinct functional plateaus between these maxima. Here, we demonstrate how the photostationary state ( PSS ) of an E / Z ‐arylazopyrazole photoswitch ca... | Introduction Multivalent interactions are of great interest for understanding (bio)chemical systems and designing molecular materials, in which molecules interact by multiple non‐covalent bonds. With respect to the bottom‐up design of materials, reversible multivalent interactions are promising in terms of the precise ... |
10. 1002/anie. 202011615 | 2,020 | Angewandte Chemie (International Ed. in English) | Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy | Abstract The softness of nanohydrogels results in unique properties and recently attracted tremendous interest due to the multi‐functionalization of interfaces. Herein, we study extremely soft temperature‐sensitive ultra‐low cross‐linked (ULC) nanogels adsorbed to the solid/water interface by atomic force microscopy (A... | Introduction Soft hydrogels, hydrogel layers and coatings of soft nanohydrogels play a major role in various fields as, e. g. , tissue engineering, cell adhesion, antifouling, [ 3, 4, 5 ] sensors, [ 6, 7 ] water purification, self‐repairing and superolephobic materials, or fertilizer. Exemplary, soft water‐swollen hydr... |
10. 1002/anie. 202013254 | 2,021 | Angewandte Chemie (International Ed. in English) | Dynamic Polymer Networks: A New Avenue towards Sustainable and Advanced Soft Machines | Abstract While the fascinating field of soft machines has grown rapidly over the last two decades, the materials they are constructed from have remained largely unchanged during this time. Parallel activities have led to significant advances in the field of dynamic polymer networks, leading to the design of three‐dimen... | 1 Introduction For centuries, machines and devices have been developed to assist in the undertaking of work in applications such as manufacturing, construction, and healthcare. During this time, significant advances in materials science, engineering, and computation have led to the creation of complex assemblies of rig... |
10. 1002/anie. 202015339 | 2,021 | Angewandte Chemie (International Ed. in English) | Well‐Defined Poly(Ester Amide)‐Based Homo‐ and Block Copolymers by One‐Pot Organocatalytic Anionic Ring‐Opening Copolymerization of | Abstract We report a new synthetic methodology for poly(ester amide)s by anionic ring‐opening copolymerization of N ‐sulfonyl aziridines and cyclic anhydrides. Phosphazenes organocatalysts have been found to promote a highly‐active, controlled, and selective alternating copolymerization in the absence of any competitiv... | Poly(ester amide)s have gained an increasing interest in recent years as they combine, in the same macromolecule, the biodegradability/biocompatibility of polyesters with excellent thermal and mechanical properties of polyamides. Therefore, they are widely used in a variety of fields, including drug delivery, hydrogels... |
10. 1002/anie. 202100064 | 2,021 | Angewandte Chemie (International Ed. in English) | Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications | Abstract Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to their high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non‐swelling protein adhesive for underwater and in vivo applications. In this sof... | Introduction Tissue adhesives and hemostatic agents have attracted tremendous attention as potential alternatives for tissue engineering and wound healing. However, those adhesives are often associated with UV‐induced crosslinking or chemical reactions, which can lead to secondary damage to traumatized tissues. Further... |
10. 1002/anie. 202103147 | 2,021 | Angewandte Chemie (International Ed. in English) | Recombinant Spider Silk Gels Derived from Aqueous–Organic Solvents as Depots for Drugs | Abstract Hydrogels are widely used in various biomedical applications, as they cannot only serve as materials for biofabrication but also as depots for the administration of drugs. However, the possibilities of formulation of water‐insoluble drugs in hydrogels are rather limited. Herein, we assembled recombinant spider... | Hydrogels are used for biomedical applications such as tissue engineering, drug delivery, and recently also biofabrication. Besides polysaccharides, such as alginate or chitosan, proteins such as Bombyx mori silkworm silk or gelatine have been processed into hydrogels using various methods. Also, hydrogel formation ... |
10. 1002/anie. 202103585 | 2,021 | Angewandte Chemie (International Ed. in English) | Real‐Time NMR Monitoring of Spatially Segregated Enzymatic Reactions in Multilayered Hydrogel Assemblies | Abstract Compartmentalized chemical reactions at the microscale are important in biotechnology, yet monitoring the molecular content at these small scales is challenging. To address this challenge, we integrate a compact, reconfigurable reaction cell featuring electrochemical functionality with high‐resolution NMR spec... | Introduction Reproducing metabolic reactions in a controlled space that mimics the native micro‐environmental conditions inside biological matter is an endeavour that can have important repercussions on bio‐medical applications. Spatial and temporal control over the processes that regulate metabolic activity allows to ... |
10. 1002/anie. 202104495 | 2,021 | Angewandte Chemie (International Ed. in English) | Heterocycle/Heteroallene Ring‐Opening Copolymerization: Selective Catalysis Delivering Alternating Copolymers | Abstract Heteroatom‐containing polymers have strong potential as sustainable replacements for petrochemicals, show controllable monomer–polymer equilibria and properties spanning plastics, elastomers, fibres, resins, foams, coatings, adhesives, and self‐assembled nanostructures. Their current and future applications sp... | 1 Introduction Synthetic polymers are structurally tuneable materials integral to modern life, whether for commodity products, such as clothing, food packaging, or house‐hold goods, or for specialist applications, such as microelectronics, renewable energy generation, or robotics. With worldwide production volumes exce... |
10. 1002/anie. 202107161 | 2,021 | Angewandte Chemie (International Ed. in English) | Using Stereochemistry to Control Mechanical Properties in Thiol–Yne Click‐Hydrogels | Abstract The stereochemistry of polymers has a profound impact on their mechanical properties. While this has been observed in thermoplastics, studies on how stereochemistry affects the bulk properties of swollen networks, such as hydrogels, are limited. Typically, changing the stiffness of a hydrogel is achieved at th... | Introduction The 3‐dimensional arrangement of bonds, or stereochemistry, dictates the function and behaviour of molecules spanning from biological systems to drugs to synthetic polymers. Stereochemistry is critical in the production of the basic building blocks of life. The chirality of deoxyribose dictates the backbon... |
10. 1002/anie. 202107960 | 2,021 | Angewandte Chemie (International Ed. in English) | Nanocarriers for Skin Applications: Where Do We Stand? | Abstract Skin penetration of active molecules for treatment of diverse diseases is a major field of research owing to the advantages associated with the skin like easy accessibility, reduced systemic‐derived side effects, and increased therapeutic efficacy. Despite these advantages, dermal drug delivery is generally ch... | 1 Introduction The skin is the largest organ of the body fulfilling a wide variety of functions that includes regulating the body temperature, impeding the loss of fluids and salts, and preventing the intrusion of pathogens like viruses, bacteria, allergens, and toxic chemicals. It also offers protection from ultraviol... |
10. 1002/anie. 202108378 | 2,021 | Angewandte Chemie (International Ed. in English) | Evaporation‐Induced Self‐Assembly of Small Peptide‐Conjugated Silica Nanoparticles | Abstract Self‐assembly processes guide disordered molecules or particles into long‐range organized structures due to specific supramolecular interactions among the building entities. Herein, we report a unique evaporation‐induced self‐assembly (EISA) strategy for four different silica nanoparticle systems obtained thro... | Molecular self‐assembly is a process which enables a defined arrangement of molecules based on specific, directional, tunable, and non‐covalent interactions. Such interactions are typically either electrostatic forces, hydrogen‐bonding, aromatic π–π stacking, or van der Waals interactions. In supramolecular chemistry, ... |
10. 1002/anie. 202110855 | 2,022 | Angewandte Chemie (International Ed. in English) | Synthetic Cells: From Simple Bio‐Inspired Modules to Sophisticated Integrated Systems | Abstract Bottom‐up synthetic biology is the science of building systems that mimic the structure and function of living cells from scratch. To do this, researchers combine tools from chemistry, materials science, and biochemistry to develop functional and structural building blocks to construct synthetic cell‐like syst... | 1 Introduction Synthetic cells are supramolecular chemical systems designed to mimic the behavior, function, and structure of living cells. Depending on how they are produced, synthetic cells can have properties and components that are not present in living systems, which significantly increases their technological val... |
10. 1002/anie. 202112842 | 2,022 | Angewandte Chemie (International Ed. in English) | Crosslinked Polypeptide Films via RAFT‐Mediated Continuous Assembly of Polymers | Abstract Polypeptide coatings are a cornerstone in the field of surface modification due to their widespread biological potential. As their properties are dictated by their structural features, subsequent control thereof using unique fabrication strategies is important. Herein, we report a facile method of precisely cr... | Introduction For decades, scientists have been deeply fascinated in surface modification via the introduction of synthetic polypeptides for a wide range of applications including biosensing, active molecule release and antibiofouling/antimicrobial applications. Polypeptides can be designed to bear application specific... |
10. 1002/anie. 202113403 | 2,021 | Angewandte Chemie (International Ed. in English) | Control over Multiple Nano‐ and Secondary Structures in Peptide Self‐Assembly | Abstract Herein, we report the rich morphological and conformational versatility of a biologically active peptide ( PEP‐1 ), which follows diverse self‐assembly pathways to form up to six distinct nanostructures and up to four different secondary structures through subtle modulation in pH, concentration and temperature... | Introduction Spontaneous self‐assembly of (macro)molecular entities is omnipresent in living systems, which not only plays a critical role in corporal functions but also regulates the formation of a wide variety of dynamic supramolecular structures over different length scales. In this regard, peptides represent prime ... |
10. 1002/anie. 202115021 | 2,021 | Angewandte Chemie (International Ed. in English) | Controlling Syneresis of Hydrogels Using Organic Salts | Abstract Supramolecular hydrogels can spontaneously undergo syneresis through fibre–fibre interactions and expel significant amounts of water upon aging. In this process, the hydrophobicity of fibres which regulates the 3D‐rearrangement of the self‐assembled structures during syneresis is important. Here, we show that ... | Supramolecular hydrogels derived from the self‐assembly of small organic molecules (called gelators) in water have applications in areas including drug delivery, tissue engineering, catalysis, and optoelectronics. Typically, self‐assembly of gelators results in fibres which are maintained by different non‐covalent inte... |
10. 1002/anie. 202115232 | 2,022 | Angewandte Chemie (International Ed. in English) | Site‐Specific Functionalization of Recombinant Spider Silk Janus Fibers | Abstract Biotechnological production is a powerful tool to design materials with customized properties. The aim of this work was to apply designed spider silk proteins to produce Janus fibers with two different functional sides. First, functionalization was established through a cysteine‐modified silk protein, ntag Cys... | Low‐cost production, easy processing, and a broad range of adjustable properties such as mechanical, thermal, optical, electrical, and biological features render polymers an all‐rounder in material science. In various fields like construction, energy, water treatment, electronics and medicine, polymers are attractive a... |
10. 1002/anie. 202201563 | 2,022 | Angewandte Chemie (International Ed. in English) | A Metal‐Ion‐Incorporated Mussel‐Inspired Poly(Vinyl Alcohol)‐Based Polymer Coating Offers Improved Antibacterial Activity and Cellular Mechanoresponse Manipulation | Abstract Cobalt (Co II ) ions have been an attractive candidate for the biomedical modification of orthopedic implants for decades. However, limited research has been performed into how immobilized Co II ions affect the physical properties of implant devices and how these changes regulate cellular behavior. In this stu... | Introduction Rapidly increasing research toward the exploration and production of implantable devices for clinical treatment has revealed an urgent need for materials with specific chemical and physical properties that can enhance their biological functions. Introducing implants into lesion sites not only provides mech... |
10. 1002/anie. 202207319 | 2,022 | Angewandte Chemie (International Ed. in English) | Aptamer‐Array‐Guided Protein Assembly Enhances Synthetic mRNA Switch Performance | Abstract Synthetic messenger RNA (mRNA) switches are powerful synthetic biological tools that can sense cellular molecules to manipulate cell fate. However, their performances are limited by high output signal noise due to leaky output protein expression. Here, we designed a readout control module that disables protein... | Synthetic mRNA switches are important type of artificial circuits that promise programmed control of living cells. Synthetic mRNA switches sense cellular molecules or traits (input) to change the expression level of the encoded protein, producing output signals for monitoring or manipulating of the target cells. Becaus... |
10. 1002/anie. 202209530 | 2,022 | Angewandte Chemie (International Ed. in English) | Memory Effect in Thermoresponsive Proline‐based Polymers | Abstract We report that synthetic polymers consisting of L ‐proline monomer units exhibit temperature‐driven aggregation in water with unprecedented hysteresis. This protein‐like behavior is robust and governed by the chirality of the proline units. It paves the way to new processes, driven by either temperature or ion... | Better understanding the key principles underlying the phase separation of macromolecules is a major challenge. In biology, phase separations of biomacromolecules are at the origin of complex intracellular organization such as the formation of membrane‐less organelles. In medicine, protein phase separations are linked ... |
10. 1002/anie. 202210208 | 2,022 | Angewandte Chemie (International Ed. in English) | Superchaotropic Nano‐ion Binding as a Gelation Motif in Cellulose Ether Solutions | Abstract Nanometer‐sized anions (nano‐ions) like polyoxometalates and boron clusters exhibit so‐called superchaotropic behavior, which describes their strong binding to hydrated non‐ionic matter in water. We show here that nano‐ions, at millimolar concentrations, dramatically enhance the viscosity and induce gelation o... | Nanometer‐sized anions (nano‐ions), such as dodecaborates and Keggin polyoxometalates (POMs), have recently emerged as potent inorganic additives for aqueous non‐ionic soft matter systems. Their sizes around one nanometer combined with ionic charges typically from −1 to −6, place nano‐ions at the boundary between class... |
10. 1002/app. 41563 | 2,014 | Journal of applied polymer science | Thiol-norbornene photo-click hydrogels for tissue engineering applications | Thiol-norbornene (thiol-ene) photo-click hydrogels have emerged as a diverse material system for tissue engineering applications. These hydrogels are cross-linked through light mediated orthogonal reactions between multi-functional norbornene-modified macromers (e. g. , poly(ethylene glycol), hyaluronic acid, gelatin) ... | No full text available |
10. 1002/app. 45569 | 2,018 | Journal of applied polymer science | Polymeric 3D Printed Structures for Soft-Tissue Engineering | 3D printing, or rapid prototyping, is a fabrication technique that is used for various engineering applications with advantages such as mass production and fine tuning of spatial-dimensional properties. Recently, this fabrication method has been adopted for tissue engineering applications due to its ability to finely t... | No full text available |
10. 1002/app. 48770 | 2,020 | Journal of applied polymer science | Multifunctional temperature-responsive polymers as advanced biomaterials and beyond | The versatility and applicability of thermoresponsive polymeric systems have led to great interest and a multitude of publications. Of particular significance, multifunctional poly( N -isopropylacrylamide) (PNIPAAm) systems based on PNIPAAm copolymerized with various functional comonomers or based on PNIPAAm combined w... | No full text available |
10. 1002/app. 50658 | 2,021 | Journal of Applied Polymer Science | Potential natural polymer‐based nanofibres for the development of facemasks in countering viral outbreaks | Abstract The global coronavirus disease 2019 (COVID‐19) pandemic has rapidly increased the demand for facemasks as a measure to reduce the rapid spread of the pathogen. Throughout the pandemic, some countries such as Italy had a monthly demand of ca. 90 million facemasks. Domestic mask manufacturers are capable of manu... | 1 INTRODUCTION 1. 1 Coronavirus and N95 facemasks Elevated use of facemasks during the coronavirus disease 2019 (COVID‐19) pandemic has raised serious environmental concerns caused by the synthetic plastics used in protective facemasks, including the prevalent N95 type masks. It is estimated that about 3. 5 billion N95... |
10. 1002/app. 52846 | 2,022 | Journal of applied polymer science | Delivery of Bioactive Albumin from Multi-Functional Polyampholyte Hydrogels | Tissue engineered scaffolds are currently being explored to aid in healing and regeneration of non-union fractures in bone. Additionally, albumin has been demonstrated to provide benefits to healing when applied to injury sites. This paper focuses on delivery of calcium modified, bioactive bovine serum albumin (BSA) fr... | No full text available |
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