PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6pp3
1.95
2,020
OS7
C
503
ki
=
23.7
uM
-4.625252
MOAD
Ki=23.7uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pp3
1.95
2,020
OS7
D
503
ki
=
23.7
uM
-4.625252
MOAD
Ki=23.7uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pp4
2.2
2,020
OUS
A
504
ki
=
7.73
uM
-5.111821
MOAD
Ki=7.73uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pp4
2.2
2,020
OUS
B
503
ki
=
7.73
uM
-5.111821
MOAD
Ki=7.73uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pp4
2.2
2,020
OUS
C
504
ki
=
7.73
uM
-5.111821
MOAD
Ki=7.73uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pp4
2.2
2,020
OUS
D
503
ki
=
7.73
uM
-5.111821
MOAD
Ki=7.73uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pq6
1.658
2,019
OVM
A
501
kd
=
69
uM
-4.161151
MOAD
Kd=69.0uM
Q2IU02
Cytochrome P450
COc1cccc(C(=O)[O-])c1
151.141
0.0587
49.36
2
11
0
3
0.600052
6pqd
1.89
2,019
OVP
A
502
kd
=
33
uM
-4.481486
MOAD
Kd=33.0uM
Q2IU02
Cytochrome P450
CSc1cccc(C(=O)[O-])c1
167.209
0.772
40.13
2
11
0
3
0.610752
6pqs
1.6
2,019
4MA
A
502
kd
=
0.66
uM
-6.180456
MOAD
Kd=0.66uM
Q2IU02
Cytochrome P450
Cc1ccc(C(=O)[O-])cc1
135.142
0.35852
40.13
1
10
0
2
0.557362
6pqw
1.679
2,019
OVV
A
501
kd
=
89
uM
-4.05061
MOAD
Kd=89.0uM
Q2IU02
Cytochrome P450
Cc1cccc(C(=O)[O-])c1
135.142
0.35852
40.13
1
10
0
2
0.557362
6pr6
2.01
2,020
OWS
A
202
ki
=
1.7
nM
-8.769551
MOAD
Ki=1.7nM
P0A017
Dihydrofolate reductase
COc1cc(Cc2cnc(N)nc2N)cc(/C=C/C(=O)N2N=Cc3ccccc3[C@@H]2c2ccc(C)cc2)c1OC
534.62
4.53632
128.95
7
40
2
8
0.333214
6pr7
2.01
2,020
OWP
A
202
ki
=
1.4
nM
-8.853872
MOAD
Ki=1.4nM
P0A017
Dihydrofolate reductase
COc1cc(Cc2cnc(N)nc2N)cc(/C=C/C(=O)N2NCc3ccccc3[C@@H]2Cc2ccccc2)c1OC
536.636
4.093
128.62
8
40
3
8
0.28734
6pr8
2.01
2,020
OWJ
A
301
ki
=
1.4
nM
-8.853872
MOAD
Ki=1.4nM
P0A017
Dihydrofolate reductase
COc1cc(Cc2cnc(N)nc2N)cc(/C=C/C(=O)N2N=Cc3ccccc3[C@@H]2c2cc(C)cc(C)c2)c1OC
548.647
4.84474
128.95
7
41
2
8
0.316112
6pr9
2.01
2,020
OWV
A
202
ki
=
2.6
nM
-8.585027
MOAD
Ki=2.6nM
P0A017
Dihydrofolate reductase
CCC(CC)[C@H]1c2ccccc2CNN1C(=O)/C=C/c1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
516.646
4.2865
128.62
9
38
3
8
0.359471
6prb
2.0
2,020
OWM
A
302
ki
=
0.7
nM
-9.154902
MOAD
Ki=0.7nM
P0A017
Dihydrofolate reductase
COc1cc2c(cc1OC)[C@@H](C1CC1)N(C(=O)/C=C/c1cc(Cc3cnc(N)nc3N)cc(OC)c1OC)N=C2
544.612
3.6068
147.41
9
40
2
10
0.385548
6prb
2.0
2,020
R0Y
A
301
ki
=
0.7
nM
-9.154902
MOAD
Ki=0.7nM
P0A017
Dihydrofolate reductase
COc1cc2c(cc1OC)[C@H](C1CC1)N(C(=O)/C=C/c1cc(Cc3cnc(N)nc3N)cc(OC)c1OC)N=C2
544.612
3.6068
147.41
9
40
2
10
0.385548
6prd
2.01
2,020
OWG
A
403
ki
=
1
nM
-9
MOAD
Ki=1.0nM
P0A017
Dihydrofolate reductase
COc1ccc([C@H]2c3cc(OC)c(OC)cc3CNN2C(=O)CCc2cc(Cc3cnc(N)nc3N)cc(OC)c2OC)cc1
614.703
3.8438
156.31
11
45
3
11
0.225541
6prf
1.21
2,019
7OA
B
101
ki
=
2.5
nM
-8.60206
MOAD
Ki=2.5nM
P03366,P03366
Protease,Protease
CC(C)CN(C[C@@H](O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)O[C@H]1[C@H]2CO[C@H]3OC[C@@H]1[C@H]3C2)S(=O)(=O)c1ccc2nc(NC3CC3)sc2c1
706.834
4.5013
139.32
13
48
3
10
0.234601
6prr
1.67
2,019
OW4
A
501
kd
=
31
uM
-4.508638
MOAD
Kd=31.0uM
Q2IU02
Cytochrome P450
CNc1cccc(C(=O)[O-])c1
150.157
0.0918
52.16
2
11
1
3
0.64971
6prs
2.373
2,019
OW7
A
502
kd
=
82
uM
-4.086186
MOAD
Kd=82.0uM
Q2IU02
Cytochrome P450
CCOc1cccc(C(=O)[O-])c1
165.168
0.4488
49.36
3
12
0
3
0.652894
6prt
1.3
2,019
OWA
A
201
ic50
=
2,120
uM
-2.673664
MOAD
ic50=2120.0uM
O60885
Bromodomain-containing protein 4
COC(=O)C[C@H]1CC(=O)N(C)C1
171.196
0.0278
46.61
2
12
0
3
0.550466
6ps2
2.4
2,019
JTZ
A
1201
ki
=
1
nM
-9
MOAD
Ki=1.0nM
null
null
C=CCc1ccccc1OC[C@@H](O)C[NH2+]C(C)C
250.362
1.1266
46.07
8
18
2
2
0.679369
6ps3
2.5
2,019
CVD
A
1201
ki
=
0.166
nM
-9.779892
MOAD
Ki=0.166nM
null
null
COc1ccccc1OCC[NH2+]C[C@H](O)COc1cccc2[nH]c3ccccc3c12
407.49
2.7118
80.32
10
30
3
4
0.353277
6ps9
1.21
2,019
Y17
A
201
ic50
=
79
uM
-4.102373
MOAD
ic50=79.0uM
O60885
Bromodomain-containing protein 4
CN1C[C@H](CCn2c3c(c4ccccc42)C(=O)NCC3)CC1=O
311.385
1.7956
54.34
3
23
1
3
0.93949
6psb
1.59
2,019
Y18
A
201
ic50
=
24
uM
-4.619789
MOAD
ic50=24.0uM
O60885
Bromodomain-containing protein 4
CN1C[C@@H](Cn2c3c(c4ccccc42)C(=O)NCC3)CC1=O
297.358
1.4055
54.34
2
22
1
3
0.910895
6psj
1.8
2,019
29S
A
601
ic50
=
50
nM
-7.30103
BindingDB
IC50=50nM
P03372
Estrogen receptor
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCC[NH+]3CCCCCC3)cc2)c2ccc(O)cc12
471.621
4.91392
59.06
7
35
3
4
0.35884
6psj
1.8
2,019
29S
B
601
ic50
=
50
nM
-7.30103
BindingDB
IC50=50nM
P03372
Estrogen receptor
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCC[NH+]3CCCCCC3)cc2)c2ccc(O)cc12
471.621
4.91392
59.06
7
35
3
4
0.35884
6pt0
NMR
2,020
WI5
R
401
ki
=
2.1
nM
-8.677781
BindingDB
Ki=2.1nM,EC50=24.6nM,IC50=3.4nM
P34972
Cannabinoid receptor 2
Cc1c(C(=O)c2cccc3ccccc23)c2cccc3c2n1[C@H](C[NH+]1CCOCC1)CO3
427.524
3.18252
44.9
4
32
1
4
0.509068
6pv7
NMR
2,019
NCT
A
701
ki
=
14
nM
-7.853872
BindingDB
Ki=14nM,EC50=9400nM,IC50=45nM
P32297,P30926
Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562,Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562
C[N@@H+]1CCC[C@H]1c1cccnc1
163.244
0.4312
17.33
1
12
1
1
0.635247
6pv7
NMR
2,019
NCT
D
701
ki
=
14
nM
-7.853872
BindingDB
Ki=14nM,EC50=9400nM,IC50=45nM
P30926,P32297
Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562,Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562
C[N@@H+]1CCC[C@H]1c1cccnc1
163.244
0.4312
17.33
1
12
1
1
0.635247
6pv8
NMR
2,019
P1M
A
701
ki
=
2.6
nM
-8.585027
BindingDB
Ki=2.6nM
P32297,P30926
Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562,Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562
C[N@@H+]1[C@@H]2CCC[C@H]1C[C@@H](Nc1ccccc1Br)C2
310.259
2.4592
16.47
2
18
2
1
0.857736
6pv8
NMR
2,019
P1M
D
701
ki
=
2.6
nM
-8.585027
BindingDB
Ki=2.6nM
P30926,P32297
Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562,Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562
C[N@@H+]1[C@@H]2CCC[C@H]1C[C@@H](Nc1ccccc1Br)C2
310.259
2.4592
16.47
2
18
2
1
0.857736
6pvc
1.96
2,020
P1J
A
402
kd
=
172
uM
-3.764472
MOAD
Kd=172.0uM
Q95460,P61769
Major histocompatibility complex class I-related gene protein,Beta-2-microglobulin
O=C([O-])CCNC(=O)c1cc(=O)[nH]c(=O)[nH]1
226.168
-3.067
134.95
4
16
3
5
0.500326
6pvc
1.96
2,020
P1J
C
301
kd
=
172
uM
-3.764472
MOAD
Kd=172.0uM
Q95460,P61769
Major histocompatibility complex class I-related gene protein,Beta-2-microglobulin
O=C([O-])CCNC(=O)c1cc(=O)[nH]c(=O)[nH]1
226.168
-3.067
134.95
4
16
3
5
0.500326
6pvd
2.14
2,020
N18
A
301
kd
=
200
uM
-3.69897
MOAD
Kd=200.0uM
Q95460,P61769
Major histocompatibility complex class I-related gene protein,Beta-2-microglobulin
COC(=O)CCNC(=O)c1cc(=O)[nH]c(=O)[nH]1
241.203
-1.6439
121.12
4
17
3
5
0.545485
6pvd
2.14
2,020
N18
C
301
kd
=
200
uM
-3.69897
MOAD
Kd=200.0uM
P61769,Q95460
Beta-2-microglobulin,Major histocompatibility complex class I-related gene protein
COC(=O)CCNC(=O)c1cc(=O)[nH]c(=O)[nH]1
241.203
-1.6439
121.12
4
17
3
5
0.545485
6pve
2.3
2,019
OZP
A
301
ki
=
43
nM
-7.366532
MOAD
Ki=43.0nM
P40261,P40261
NNMT protein,NNMT protein
NC(=O)c1cccc(CCC[N@@H+](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
529.578
-4.6052
234.61
12
38
6
11
0.131239
6pve
2.3
2,019
OZP
B
301
ki
=
43
nM
-7.366532
MOAD
Ki=43.0nM
P40261
NNMT protein
NC(=O)c1cccc(CCC[N@@H+](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
529.578
-4.6052
234.61
12
38
6
11
0.131239
6pve
2.3
2,019
OZP
C
301
ki
=
43
nM
-7.366532
MOAD
Ki=43.0nM
P40261,P40261
NNMT protein,NNMT protein
NC(=O)c1cccc(CCC[N@@H+](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
529.578
-4.6052
234.61
12
38
6
11
0.131239
6pve
2.3
2,019
OZP
D
301
ki
=
43
nM
-7.366532
MOAD
Ki=43.0nM
P40261
NNMT protein
NC(=O)c1cccc(CCC[N@@H+](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
529.578
-4.6052
234.61
12
38
6
11
0.131239
6pvv
1.65
2,019
5FA
A
201
ki
=
1.4
uM
-5.853872
MOAD
Ki=1.4uM
P61823
Ribonuclease pancreatic
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)([O-])O[P@](=O)([O-])O[P@](=O)([O-])O[P@@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]1O
661.092
-5.187
389.17
12
39
3
24
0.178872
6pvv
1.65
2,019
5FA
B
201
ki
=
1.4
uM
-5.853872
MOAD
Ki=1.4uM
P61823
Ribonuclease pancreatic
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)([O-])O[P@@](=O)([O-])O[P@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]1O
661.092
-5.187
389.17
12
39
3
24
0.178872
6pvw
1.6
2,019
OZV
A
201
ki
=
0.48
uM
-6.318759
MOAD
Ki=0.48uM
P61823
Ribonuclease pancreatic
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)([O-])O[P@]2(=O)O[P@@](=O)([O-])O[P@](=O)([O-])O[P@](=O)([O-])O2)[C@@H](O)[C@H]1O
645.093
-2.8774
352.28
6
38
3
23
0.265517
6pvx
1.55
2,019
U5F
A
201
ki
=
0.068
uM
-7.167491
MOAD
Ki=0.068uM
P61823
Ribonuclease pancreatic
O=c1ccn([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@@](=O)([O-])O[P@@](=O)([O-])O[P@@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c(=O)[nH]1
638.05
-6.0589
374.41
12
37
3
22
0.179254
6pvx
1.55
2,019
U5F
A
202
ki
=
0.068
uM
-7.167491
MOAD
Ki=0.068uM
P61823
Ribonuclease pancreatic
O=c1ccn([C@@H]2O[C@H](CO[P@@](=O)([O-])O[P@](=O)([O-])O[P@@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c(=O)[nH]1
638.05
-6.0589
374.41
12
37
3
22
0.179254
6pvx
1.55
2,019
U5F
B
201
ki
=
0.068
uM
-7.167491
MOAD
Ki=0.068uM
P61823,P61823
Ribonuclease pancreatic,Ribonuclease pancreatic
O=c1ccn([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@@](=O)([O-])O[P@@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c(=O)[nH]1
638.05
-6.0589
374.41
12
37
3
22
0.179254
6pvy
1.74
2,019
OZG
A
201
kd
=
639
uM
-3.194499
MOAD
Kd=639.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
COc1cccc(Oc2ccc3c(CC(=O)[O-])coc3c2)c1
297.286
2.5261
71.73
5
22
0
5
0.723318
6pvz
1.99
2,019
OZM
A
201
kd
=
341
uM
-3.467246
MOAD
Kd=341.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
O=C([O-])Cc1coc2cc(Cc3ccccc3)ccc12
265.288
2.316
53.27
4
20
0
3
0.727073
6pws
1.0
2,019
MMA
A
303
ki
=
1.6
mM
-2.79588
MOAD
Ki=1.6mM
E1BIQ4
Fc fragment of IgE receptor II
CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6pya
1.71
2,019
P57
A
301
ic50
=
150
nM
-6.823909
MOAD
ic50=150.0nM
P04278
Sex hormone-binding globulin
c1ccc(-c2[nH]c3ccccc3c2Cn2ccnc2)cc1
273.339
4.0797
33.61
3
21
1
2
0.599262
6pyb
1.8
2,019
P5G
A
301
ic50
=
4,200
nM
-5.376751
MOAD
ic50=4200.0nM
P04278
Sex hormone-binding globulin
COc1cc(C[C@H]2COC[C@@H]2Cc2ccc(O)c(OC)c2)ccc1O
344.407
3.1628
68.15
6
25
2
5
0.842417
6pye
1.48000295888
2,020
P5Y
A
801
ic50
=
0.03
uM
-7.522879
MOAD
ic50=0.03uM
F8W4B7
Hdac6 protein
O=C(NO)c1ccc(CN(Cc2nnnn2Cc2ccccc2)C(=O)c2ccccc2C(F)(F)F)cc1
510.476
3.7018
113.24
8
37
2
7
0.276147
6pye
1.48000295888
2,020
P5Y
B
801
ic50
=
0.03
uM
-7.522879
MOAD
ic50=0.03uM
F8W4B7
Hdac6 protein
O=C(NO)c1ccc(CN(Cc2nnnn2Cc2ccccc2)C(=O)c2ccccc2C(F)(F)F)cc1
510.476
3.7018
113.24
8
37
2
7
0.276147
6pyf
1.73
2,019
EST
A
302
kd
=
1.5
nM
-8.823909
BindingDB
IC50=50nM,Kd=1.5nM
P04278
Sex hormone-binding globulin
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O
272.388
3.6092
40.46
0
20
2
2
0.75717
6pyr
2.21
2,019
P5J
A
1101
ic50
=
1
nM
-9
MOAD
ic50=1.0nM
O00329
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Cc1ncc(-c2ccn3ncc(-c4ccc5c(c4)[C@](C)(Cc4ccccc4)C(=O)N5)c3n2)cn1
446.514
4.61422
85.07
4
34
1
6
0.435636
6pyu
2.54
2,019
P5V
A
1101
ic50
=
10
nM
-8
BindingDB
IC50=10.0nM
O00329
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
O=C(C1CC1)N1CCC[C@]12C(=O)Nc1ccc(-c3ccc4nccnc4c3)cc12
384.439
3.4766
75.19
2
29
1
4
0.734038
6pyy
2.4
2,020
H7S
A
403
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
A
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
B
403
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
B
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
C
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
C
403
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
D
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyy
2.4
2,020
H7S
D
403
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyz
2.02
2,020
H7S
A
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyz
2.02
2,020
H7S
B
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyz
2.02
2,020
H7S
C
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pyz
2.02
2,020
H7S
D
402
ic50
=
424
uM
-3.372634
MOAD
ic50=424.0uM
P48775,P48775
Tryptophan 2,3-dioxygenase,Tryptophan 2,3-dioxygenase
O=C1C[C@@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pz1
2.65
2,020
AOJ
A
502
kd
=
14,000
nM
-4.853872
BindingDB
IC50=410nM,Kd=14000nM
P14902,P14902
Indoleamine 2,3-dioxygenase 1,Indoleamine 2,3-dioxygenase 1
O=C1C[C@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pz1
2.65
2,020
AOJ
B
503
kd
=
14,000
nM
-4.853872
BindingDB
IC50=410nM,Kd=14000nM
P14902,P14902
Indoleamine 2,3-dioxygenase 1,Indoleamine 2,3-dioxygenase 1
O=C1C[C@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pz1
2.65
2,020
AOJ
B
502
kd
=
14,000
nM
-4.853872
BindingDB
IC50=410nM,Kd=14000nM
P14902,P14902
Indoleamine 2,3-dioxygenase 1,Indoleamine 2,3-dioxygenase 1
O=C1C[C@H](c2c[nH]c3ccc(F)cc23)C(=O)N1
232.214
1.4371
61.96
1
17
2
2
0.730591
6pz4
1.85
2,019
P6J
A
506
ic50
=
0.4
nM
-9.39794
MOAD
ic50=0.4nM
P56817
Beta-secretase 1
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)[NH+]=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1
474.513
0.7815
113.33
7
33
3
7
0.508567
6q0d
2.05
2,020
P8M
A
502
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CCCC4)c3)nn(-c3nc(C(=O)[O-])cs3)c2CC2CC2)cc1F
621.711
4.3699
131
8
43
1
8
0.29095
6q0d
2.05
2,020
P8M
B
502
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CCCC4)c3)nn(-c3nc(C(=O)[O-])cs3)c2CC2CC2)cc1F
621.711
4.3699
131
8
43
1
8
0.29095
6q0d
2.05
2,020
P8M
C
502
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CCCC4)c3)nn(-c3nc(C(=O)[O-])cs3)c2CC2CC2)cc1F
621.711
4.3699
131
8
43
1
8
0.29095
6q0d
2.05
2,020
P8M
D
502
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CCCC4)c3)nn(-c3nc(C(=O)[O-])cs3)c2CC2CC2)cc1F
621.711
4.3699
131
8
43
1
8
0.29095
6q0d
2.05
2,020
P8M
E
405
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P00338
L-lactate dehydrogenase A chain
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CCCC4)c3)nn(-c3nc(C(=O)[O-])cs3)c2CC2CC2)cc1F
621.711
4.3699
131
8
43
1
8
0.29095
6q0d
2.05
2,020
P8M
F
502
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P00338
L-lactate dehydrogenase A chain
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CCCC4)c3)nn(-c3nc(C(=O)[O-])cs3)c2CC2CC2)cc1F
621.711
4.3699
131
8
43
1
8
0.29095
6q0q
1.98601176315
2,020
P8G
A
302
kd
=
535
mM
-0.271646
MOAD
Kd=535.0mM
P17931
Galectin-3
CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OCc2cn([C@@H]3O[C@H](CO)[C@H](O)[C@H](OCc4cn([C@@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5O)nn4)[C@H]3O)nn2)[C@H]1O
680.621
-6.9905
319.1
12
47
10
22
0.099513
6q13
2.0
2,020
P8V
A
402
ic50
=
40
nM
-7.39794
MOAD
ic50=40.0nM
P00338,P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
Cc1ccc(C#Cc2cccc(-c3nn(-c4nc(C(=O)[O-])cs4)c(CC4CC4)c3Cc3ccc(S(N)(=O)=O)c(F)c3)c2)s1
631.756
4.45882
131
8
43
1
9
0.251829
6q13
2.0
2,020
P8V
B
402
ic50
=
40
nM
-7.39794
MOAD
ic50=40.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
Cc1ccc(C#Cc2cccc(-c3nn(-c4nc(C(=O)[O-])cs4)c(CC4CC4)c3Cc3ccc(S(N)(=O)=O)c(F)c3)c2)s1
631.756
4.45882
131
8
43
1
9
0.251829
6q13
2.0
2,020
P8V
C
402
ic50
=
40
nM
-7.39794
MOAD
ic50=40.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
Cc1ccc(C#Cc2cccc(-c3nn(-c4nc(C(=O)[O-])cs4)c(CC4CC4)c3Cc3ccc(S(N)(=O)=O)c(F)c3)c2)s1
631.756
4.45882
131
8
43
1
9
0.251829
6q13
2.0
2,020
P8V
D
402
ic50
=
40
nM
-7.39794
MOAD
ic50=40.0nM
P00338,P00338
L-lactate dehydrogenase A chain,L-lactate dehydrogenase A chain
Cc1ccc(C#Cc2cccc(-c3nn(-c4nc(C(=O)[O-])cs4)c(CC4CC4)c3Cc3ccc(S(N)(=O)=O)c(F)c3)c2)s1
631.756
4.45882
131
8
43
1
9
0.251829
6q17
1.98
2,020
P8J
A
301
kd
=
972
mM
-0.012334
MOAD
Kd=972.0mM
P17931
Galectin-3
CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OCc2cn([C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)nn2)[C@H]1O
437.402
-4.7789
209.24
7
30
7
14
0.213822
6q3y
1.2
2,019
HG5
A
202
kd
=
54
nM
-7.267606
MOAD
Kd=54.0nM
O60885,O60885
Bromodomain-containing protein 4,Bromodomain-containing protein 4
CCOc1cc([C@H]2CC[N@H+](C)CC2)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)[C@H](CC)C(=O)N2C
515.682
3.7726
75.03
8
38
2
6
0.475835
6q3y
1.2
2,019
HG5
B
204
kd
=
54
nM
-7.267606
MOAD
Kd=54.0nM
O60885,O60885
Bromodomain-containing protein 4,Bromodomain-containing protein 4
CCOc1cc([C@H]2CC[N@H+](C)CC2)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)[C@H](CC)C(=O)N2C
515.682
3.7726
75.03
8
38
2
6
0.475835
6q3z
2.0
2,019
HG8
A
201
kd
=
44
nM
-7.356547
MOAD
Kd=44.0nM
O60885
Bromodomain-containing protein 4
CCOc1cc([C@H]2CC[N@H+](C)CC2)ccc1Nc1ncc2c(n1)N(Cc1cc(C)cs1)[C@H](CC)C(=O)N2C
535.738
4.14252
75.03
8
38
2
7
0.451689
6q3z
2.0
2,019
HG8
B
201
kd
=
44
nM
-7.356547
MOAD
Kd=44.0nM
O60885,O60885
Bromodomain-containing protein 4,Bromodomain-containing protein 4
CCOc1cc([C@H]2CC[N@H+](C)CC2)ccc1Nc1ncc2c(n1)N(Cc1cc(C)cs1)[C@H](CC)C(=O)N2C
535.738
4.14252
75.03
8
38
2
7
0.451689
6q4e
1.06
2,019
HH5
A
303
kd
=
350
uM
-3.455932
MOAD
Kd=350.0uM
P24941
Cyclin-dependent kinase 2
Nc1nc(I)c2[nH]cnc2n1
261.026
0.5397
80.48
0
11
2
4
0.53538
6q4g
0.98
2,019
HJK
A
301
kd
=
50
uM
-4.30103
MOAD
Kd=50.0uM
P24941
Cyclin-dependent kinase 2
Nc1nc(-c2cccc(CC(=O)[O-])c2)c2nc[nH]c2n1
268.256
-0.1055
120.61
3
20
2
6
0.683545
6q54
1.4
2,019
HJ8
A
307
ki
=
710
nM
-6.148742
BindingDB
EC50=65000nM,Ki=710nM
P19491
Glutamate receptor 2
CCn1nnc(O)c1C[C@H]([NH3+])C(=O)[O-]
200.198
-3.0935
118.71
4
14
2
6
0.53343
6q54
1.4
2,019
HJ8
B
305
ki
=
710
nM
-6.148742
BindingDB
EC50=65000nM,Ki=710nM
P19491
Glutamate receptor 2
CCn1nnc(O)c1C[C@H]([NH3+])C(=O)[O-]
200.198
-3.0935
118.71
4
14
2
6
0.53343
6q60
1.55
2,019
HJH
A
301
ki
=
1,970
nM
-5.705534
BindingDB
Ki=1970nM
P19491
Glutamate receptor 2
Cn1nc(O)c(C[C@H]([NH3+])C(=O)[O-])n1
186.171
-3.5764
118.71
3
13
2
6
0.505627
6q60
1.55
2,019
HJH
B
301
ki
=
1,970
nM
-5.705534
BindingDB
Ki=1970nM
P19491
Glutamate receptor 2
Cn1nc(O)c(C[C@H]([NH3+])C(=O)[O-])n1
186.171
-3.5764
118.71
3
13
2
6
0.505627
6q67
2.249
2,019
BGC
A
601
kd
=
0.17
uM
-6.769551
MOAD
Kd=0.17uM
Q6DUB6
Peripherial benzodiazepine receptor associated protein
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
180.156
-3.2214
110.38
1
12
5
6
0.290153
6q6m
2.35
2,019
HJW
A
501
ic50
=
128
nM
-6.89279
MOAD
ic50=128.0nM
P51449
Nuclear receptor ROR-gamma
CCOC(=O)[C@H](C)N(C(=O)c1cccs1)c1c(C)cccc1Cl
351.855
4.30832
46.61
5
23
0
4
0.753994
6q6o
2.3
2,019
HKE
A
501
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
P51449
Nuclear receptor ROR-gamma
CC(C)OC(=O)[C@H](C)N(C(=O)c1ccco1)c1c(Cl)cccc1Cl
370.232
4.5733
59.75
5
24
0
4
0.723573
6q7a
2.2
2,019
HKZ
A
501
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
P51449
Nuclear receptor ROR-gamma
Cc1c(Cc2ccccc2)nc(-c2ccco2)n1-c1c(Cl)cccc1Cl
383.278
6.33832
30.96
4
26
0
3
0.411835
6q7h
2.3
2,019
HL8
A
502
ic50
=
21
nM
-7.677781
MOAD
ic50=21.0nM
P51449
Nuclear receptor ROR-gamma
Cc1c(C(F)(F)F)nc(-c2ccc(Cl)o2)n1-c1c(Cl)ccc(N2CC(C(=O)[O-])C2)c1Cl
493.676
4.60582
74.33
4
31
0
6
0.530818
6q7h
2.3
2,019
HL8
A
501
ic50
=
21
nM
-7.677781
MOAD
ic50=21.0nM
P51449
Nuclear receptor ROR-gamma
Cc1c(C(F)(F)F)nc(-c2ccc(Cl)o2)n1-c1c(Cl)ccc(N2CC(C(=O)[O-])C2)c1Cl
493.676
4.60582
74.33
4
31
0
6
0.530818