PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6q8k
2.29
2,019
FG9
A
502
ic50
=
290
nM
-6.537602
MOAD
ic50=290.0nM
P49759
Dual specificity protein kinase CLK1
Nc1c2ccncc2cc2cnc(NCCC[NH+]3CCOCC3)nc12
339.423
0.4773
90.39
5
25
3
6
0.355789
6q96
1.8
2,019
HRE
A
201
ic50
=
0.1
nM
-10
MOAD
ic50=0.1nM
Q00987,Q00987
E3 ubiquitin-protein ligase Mdm2,E3 ubiquitin-protein ligase Mdm2
COc1nc(N(C)C)ncc1-n1nc2c(c1C(C)C)[C@H](c1ccc(C#N)cc1)N(c1cc(Cl)c[nH]c1=O)C2=O
545.003
3.82348
133.03
6
39
1
9
0.387058
6q96
1.8
2,019
HRE
B
201
ic50
=
0.1
nM
-10
MOAD
ic50=0.1nM
Q00987,Q00987
E3 ubiquitin-protein ligase Mdm2,E3 ubiquitin-protein ligase Mdm2
COc1nc(N(C)C)ncc1-n1nc2c(c1C(C)C)[C@H](c1ccc(C#N)cc1)N(c1cc(Cl)c[nH]c1=O)C2=O
545.003
3.82348
133.03
6
39
1
9
0.387058
6q9h
2.0
2,019
HRH
A
201
ic50
=
7.8
nM
-8.107905
MOAD
ic50=7.8nM
Q00987
E3 ubiquitin-protein ligase Mdm2
Cc1cc(Cl)ccc1[C@H]1c2c(C(C)C)n[nH]c2C(=O)N1c1cccc(Cl)c1F
418.299
6.03722
48.99
3
28
1
2
0.564133
6q9l
1.13
2,019
HTZ
A
201
ic50
=
3.9
nM
-8.408935
MOAD
ic50=3.9nM
Q00987
E3 ubiquitin-protein ligase Mdm2
C[NH+](C)CCC[N@H+](C)[C@H]1CCN(C(=O)c2[nH]c3cc(Cl)ccc3c2-c2c(-c3ccccc3)ncn2Cc2ccc(Cl)cc2CO)C1
661.678
3.8096
83.03
11
46
4
4
0.173983
6q9l
1.13
2,019
HTZ
B
201
ic50
=
3.9
nM
-8.408935
MOAD
ic50=3.9nM
Q00987
E3 ubiquitin-protein ligase Mdm2
C[NH+](C)CCC[N@H+](C)[C@H]1CCN(C(=O)c2[nH]c3cc(Cl)ccc3c2-c2c(-c3ccccc3)ncn2Cc2ccc(Cl)cc2CO)C1
661.678
3.8096
83.03
11
46
4
4
0.173983
6q9o
1.21
2,019
HU8
A
201
ic50
=
3.4
nM
-8.468521
MOAD
ic50=3.4nM
Q00987,Q00987
E3 ubiquitin-protein ligase Mdm2,E3 ubiquitin-protein ligase Mdm2
CC(C)(C)NC(=O)Cc1ccc(Cl)cc1-n1c(C2CCCCC2)nc(-c2nnn[nH]2)c1-c1ccc(F)c(Cl)c1
570.5
6.6702
101.38
6
39
2
6
0.269729
6q9o
1.21
2,019
HU8
B
201
ic50
=
3.4
nM
-8.468521
MOAD
ic50=3.4nM
Q00987,Q00987
E3 ubiquitin-protein ligase Mdm2,E3 ubiquitin-protein ligase Mdm2
CC(C)(C)NC(=O)Cc1ccc(Cl)cc1-n1c(C2CCCCC2)nc(-c2nnn[nH]2)c1-c1ccc(F)c(Cl)c1
570.5
6.6702
101.38
6
39
2
6
0.269729
6q9q
2.1
2,019
HUE
A
201
ic50
=
145
nM
-6.838632
MOAD
ic50=145.0nM
O15151,O15151,O15151
Protein Mdm4,Protein Mdm4,Protein Mdm4
C[C@@H](c1ccc(Cl)cc1)n1cnc(-c2ccccc2)c1-c1c(C(=O)NCC[NH+]2CCN(C3CCCCC3)CC2)[nH]c2cc(Cl)ccc12
670.709
6.8775
70.39
9
47
3
4
0.160331
6q9q
2.1
2,019
HUE
B
201
ic50
=
145
nM
-6.838632
MOAD
ic50=145.0nM
O15151,O15151,O15151
Protein Mdm4,Protein Mdm4,Protein Mdm4
C[C@@H](c1ccc(Cl)cc1)n1cnc(-c2ccccc2)c1-c1c(C(=O)NCC[NH+]2CCN(C3CCCCC3)CC2)[nH]c2cc(Cl)ccc12
670.709
6.8775
70.39
9
47
3
4
0.160331
6q9q
2.1
2,019
HUE
C
201
ic50
=
145
nM
-6.838632
MOAD
ic50=145.0nM
O15151,O15151
Protein Mdm4,Protein Mdm4
C[C@@H](c1ccc(Cl)cc1)n1cnc(-c2ccccc2)c1-c1c(C(=O)NCC[NH+]2CCN(C3CCCCC3)CC2)[nH]c2cc(Cl)ccc12
670.709
6.8775
70.39
9
47
3
4
0.160331
6q9q
2.1
2,019
HUE
D
201
ic50
=
145
nM
-6.838632
MOAD
ic50=145.0nM
O15151
Protein Mdm4
C[C@@H](c1ccc(Cl)cc1)n1cnc(-c2ccccc2)c1-c1c(C(=O)NCC[NH+]2CCN(C3CCCCC3)CC2)[nH]c2cc(Cl)ccc12
670.709
6.8775
70.39
9
47
3
4
0.160331
6q9s
2.4
2,019
HRN
A
201
ic50
=
17
nM
-7.769551
MOAD
ic50=17.0nM
O15151
Protein Mdm4
C[C@@H](c1ccc(Cl)cc1Cl)n1cnc(-c2ccccc2)c1-c1c(C(=O)Nc2cc(C(=O)[O-])ccc2N2CCC(N3CCCOC3=O)CC2)[nH]c2cc(Cl)ccc12
811.146
8.6948
135.62
9
56
2
8
0.149225
6q9s
2.4
2,019
HRN
B
201
ic50
=
17
nM
-7.769551
MOAD
ic50=17.0nM
O15151,O15151
Protein Mdm4,Protein Mdm4
C[C@@H](c1ccc(Cl)cc1Cl)n1cnc(-c2ccccc2)c1-c1c(C(=O)Nc2cc(C(=O)[O-])ccc2N2CCC(N3CCCOC3=O)CC2)[nH]c2cc(Cl)ccc12
811.146
8.6948
135.62
9
56
2
8
0.149225
6q9s
2.4
2,019
HRN
C
201
ic50
=
17
nM
-7.769551
MOAD
ic50=17.0nM
O15151
Protein Mdm4
C[C@@H](c1ccc(Cl)cc1Cl)n1cnc(-c2ccccc2)c1-c1c(C(=O)Nc2cc(C(=O)[O-])ccc2N2CCC(N3CCCOC3=O)CC2)[nH]c2cc(Cl)ccc12
811.146
8.6948
135.62
9
56
2
8
0.149225
6q9u
2.4
2,019
HRE
A
201
ic50
=
1,300
nM
-5.886057
MOAD
ic50=1300.0nM
O15151
Protein Mdm4
COc1nc(N(C)C)ncc1-n1nc2c(c1C(C)C)[C@H](c1ccc(C#N)cc1)N(c1cc(Cl)c[nH]c1=O)C2=O
545.003
3.82348
133.03
6
39
1
9
0.387058
6q9y
1.2
2,019
HRQ
A
201
ic50
=
3,700
nM
-5.431798
MOAD
ic50=3700.0nM
O15151,O15151
Protein Mdm4,Protein Mdm4
COc1cccc2c(C(=O)N[C@H]3CCN(c4ccc(C)cc4)C3)c[nH]c12
349.434
3.49362
57.36
4
26
2
3
0.757955
6q9y
1.2
2,019
HRQ
B
201
ic50
=
3,700
nM
-5.431798
MOAD
ic50=3700.0nM
O15151,O15151
Protein Mdm4,Protein Mdm4
COc1cccc2c(C(=O)N[C@H]3CCN(c4ccc(C)cc4)C3)c[nH]c12
349.434
3.49362
57.36
4
26
2
3
0.757955
6qa6
2.4
2,019
HT8
A
1102
ki
=
2.11
uM
-5.675718
MOAD
Ki=2.11uM
P00489
Glycogen phosphorylase, muscle form
O=C1NC(c2ccc3ccccc3c2)=N[C@@]12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
358.35
-1.1137
131.61
2
26
5
7
0.462412
6qa6
2.4
2,019
HT8
A
1103
ki
=
2.11
uM
-5.675718
MOAD
Ki=2.11uM
P00489
Glycogen phosphorylase, muscle form
O=C1NC(c2ccc3ccccc3c2)=N[C@@]12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
358.35
-1.1137
131.61
2
26
5
7
0.462412
6qa7
2.36
2,019
HTW
A
901
ki
=
13
uM
-4.886057
MOAD
Ki=13.0uM
P00489
Glycogen phosphorylase, muscle form
O=C1NC(c2cccc3ccccc23)=N[C@@]12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
358.35
-1.1137
131.61
2
26
5
7
0.462412
6qa8
2.35
2,019
HTE
A
901
ki
=
9
uM
-5.045757
MOAD
Ki=9.0uM
P00489
Glycogen phosphorylase, muscle form
O=C1NC(c2ccccc2)=N[C@@]12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
308.29
-2.2669
131.61
2
22
5
7
0.418645
6qaa
1.897
2,019
HUN
A
613
ic50
=
22
nM
-7.657577
MOAD
ic50=22.0nM
P06276
Cholinesterase
CCCC[NH2+][C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCC1CCCCCC1
384.588
3.9192
61.5
10
28
3
1
0.421899
6qab
2.49
2,019
HUQ
A
618
ic50
=
6.2
nM
-8.207608
MOAD
ic50=6.2nM
P06276
Cholinesterase
CCCC[N+](C)(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCC1CCCCCC1
412.642
5.4322
44.89
10
30
2
1
0.396425
6qad
2.497
2,019
HUZ
A
618
ic50
=
14
nM
-7.853872
MOAD
ic50=14.0nM
P06276
Cholinesterase
CCCC[NH2+][C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC[C@H]1CC[C@H]([NH+](C)C)CC1
414.638
1.6521
65.94
11
30
4
1
0.41522
6qae
2.487
2,019
HUK
A
612
ic50
=
3
nM
-8.522879
MOAD
ic50=3.0nM
P06276
Cholinesterase
CCCC[N@H+](C)[C@@H](Cc1c[nH]c2ccccc12)C[N@H+](C)CCC1CCCCCC1
399.667
3.269
24.67
11
29
3
0
0.483462
6qau
2.48
2,019
1FV
A
301
ic50
=
38
nM
-7.420216
BindingDB
IC50=38nM
Q8IYT8,Q8IYT8
Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2
O=C(NCCCNc1nc(Nc2cccc(C[NH+]3CCOCC3)c2)ncc1C1CC1)C1CCC1
465.622
2.231
92.61
11
34
4
6
0.380573
6qau
2.48
2,019
1FV
B
301
ic50
=
38
nM
-7.420216
BindingDB
IC50=38nM
Q8IYT8
Serine/threonine-protein kinase ULK2
O=C(NCCCNc1nc(Nc2cccc(C[NH+]3CCOCC3)c2)ncc1C1CC1)C1CCC1
465.622
2.231
92.61
11
34
4
6
0.380573
6qau
2.48
2,019
1FV
C
301
ic50
=
38
nM
-7.420216
BindingDB
IC50=38nM
Q8IYT8
Serine/threonine-protein kinase ULK2
O=C(NCCCNc1nc(Nc2cccc(C[NH+]3CCOCC3)c2)ncc1C1CC1)C1CCC1
465.622
2.231
92.61
11
34
4
6
0.380573
6qav
2.05
2,019
HVH
A
301
ic50
=
1.1
nM
-8.958607
BindingDB
IC50=1.1nM
Q8IYT8,Q8IYT8
Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2
C[N@@H+]1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
435.596
2.3867
83.38
9
32
4
5
0.454821
6qav
2.05
2,019
HVH
B
301
ic50
=
1.1
nM
-8.958607
BindingDB
IC50=1.1nM
Q8IYT8,Q8IYT8
Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2
C[N@H+]1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
435.596
2.3867
83.38
9
32
4
5
0.454821
6qav
2.05
2,019
HVH
C
301
ic50
=
1.1
nM
-8.958607
BindingDB
IC50=1.1nM
Q8IYT8,Q8IYT8
Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2
C[N@@H+]1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
435.596
2.3867
83.38
9
32
4
5
0.454821
6qav
2.05
2,019
HVH
D
301
ic50
=
1.1
nM
-8.958607
BindingDB
IC50=1.1nM
Q8IYT8,Q8IYT8
Serine/threonine-protein kinase ULK2,Serine/threonine-protein kinase ULK2
C[N@@H+]1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
435.596
2.3867
83.38
9
32
4
5
0.454821
6qba
1.8
2,020
2T1
A
201
ic50
=
15
nM
-7.823909
BindingDB
IC50=15nM
P02753,P61991
Retinol-binding protein 4,DNA-binding protein 7a
O=C([O-])c1ccccc1NC(=O)N1CCC(c2ccccc2C(F)(F)F)CC1
391.369
3.4804
72.47
3
28
1
3
0.870787
6qbg
1.8
2,020
HVT
A
103
ic50
=
0.6
nM
-9.221849
MOAD
ic50=0.6nM
P07339,P07339
Cathepsin D,Cathepsin D
CC(C)[C@@H]1NC(=O)C[C@H](O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCCCCCCCCCCNC1=O
537.745
4.7897
107.53
3
39
4
4
0.451556
6qbg
1.8
2,020
HVT
B
402
ic50
=
0.6
nM
-9.221849
MOAD
ic50=0.6nM
P07339,P07339
Cathepsin D,Cathepsin D
CC(C)[C@@H]1NC(=O)C[C@H](O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCCCCCCCCCCNC1=O
537.745
4.7897
107.53
3
39
4
4
0.451556
6qbh
1.85
2,020
S43
A
103
ic50
=
2.5
nM
-8.60206
MOAD
ic50=2.5nM
P07339,P07339
Cathepsin D,Cathepsin D
CC(C)[C@@H]1NC(=O)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCCCCCCCCCCCNC1=O
503.684
3.8564
116.76
3
36
4
5
0.499845
6qcb
1.55
2,020
HWE
A
102
ic50
=
5.8
nM
-8.236572
MOAD
ic50=5.8nM
P07339,P07339
Cathepsin D,Cathepsin D
CC(C)[C@@H]1NC(=O)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)CCCCCCCCCCCNC1=O
487.685
3.6365
107.53
3
35
4
4
0.522081
6qd9
1.46
2,020
HWT
A
1002
ic50
=
2.7
uM
-5.568636
MOAD
ic50=2.7uM
Q4Q5S8
Glycylpeptide N-tetradecanoyltransferase
CN(CCC[NH+](C)C)c1nc(N(C)CCC#N)c2sccc2n1
333.485
1.01198
60.49
8
23
1
6
0.781249
6qda
1.6
2,020
HWZ
A
1004
ic50
=
0.24
uM
-6.619789
MOAD
ic50=0.24uM
Q4Q5S8
Glycylpeptide N-tetradecanoyltransferase
CN(CCC#N)c1nc(N(C)[C@H]2CC[N@@H+](C)CC2)nc2ccccc12
339.467
1.09298
60.49
5
25
1
5
0.883682
6qda
1.6
2,020
HWZ
A
1003
ic50
=
0.24
uM
-6.619789
MOAD
ic50=0.24uM
Q4Q5S8
Glycylpeptide N-tetradecanoyltransferase
CN(CCC#N)c1nc(N(C)[C@H]2CC[N@H+](C)CC2)nc2ccccc12
339.467
1.09298
60.49
5
25
1
5
0.883682
6qdc
1.4
2,020
HXE
A
1003
ic50
=
0.62
uM
-6.207608
MOAD
ic50=0.62uM
Q4Q5S8
Glycylpeptide N-tetradecanoyltransferase
CC[N@H+]1CC[C@H](N(C)c2nc(N(C)CCC#N)c3sccc3n2)CC1
359.523
1.54458
60.49
6
25
1
6
0.847836
6qdc
1.4
2,020
HXE
A
1004
ic50
=
0.62
uM
-6.207608
MOAD
ic50=0.62uM
Q4Q5S8
Glycylpeptide N-tetradecanoyltransferase
CC[N@H+]1CC[C@@H](N(C)c2nc(N(C)CCC#N)c3sccc3n2)CC1
359.523
1.54458
60.49
6
25
1
6
0.847836
6qe0
1.394
2,019
HZ2
A
301
kd
=
25
uM
-4.60206
MOAD
Kd=25.0uM
P37634
Ribosomal RNA large subunit methyltransferase J
Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[N@@H+](CCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)CC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
661.657
-7.4736
317.07
13
47
9
19
0.06422
6qe5
1.61
2,019
SAH
A
301
kd
=
7.5
uM
-5.124939
MOAD
Kd=7.5uM
P37634
Ribosomal RNA large subunit methyltransferase J
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6qe5
1.61
2,019
SAH
B
301
kd
=
7.5
uM
-5.124939
MOAD
Kd=7.5uM
P37634
Ribosomal RNA large subunit methyltransferase J
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
384.418
-3.4886
187.08
7
26
4
11
0.348875
6qeb
NMR
2,019
AZM
A
302
kd
=
17
nM
-7.769551
BindingDB
Ki=12nM,Kd=17nM,IC50=10nM
P00918
Carbonic anhydrase 2
CC(=O)Nc1nnc(S(N)(=O)=O)s1
222.251
-0.8561
115.04
2
13
2
6
0.631859
6qed
1.8
2,019
HZK
A
506
ic50
=
0.015
uM
-7.823909
MOAD
ic50=0.015uM
P50579
Methionine aminopeptidase 2
O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2N1
431.851
2.148
98.74
4
30
3
4
0.645827
6qef
1.79
2,019
HZW
A
507
ic50
=
0.06
uM
-7.221849
MOAD
ic50=0.06uM
P50579
Methionine aminopeptidase 2
O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2ccccc2)C1=O
362.788
2.2633
69.64
4
25
2
3
0.819647
6qeg
2.08
2,019
K4K
A
502
ic50
=
0.05
uM
-7.30103
MOAD
ic50=0.05uM
P50579
Methionine aminopeptidase 2
O=C(NCCc1cccs1)[C@@]1(O)CCN(c2ccccc2)C1=O
330.409
1.5748
69.64
5
23
2
4
0.817876
6qeh
2.17
2,019
HZQ
A
502
ic50
=
55
nM
-7.259637
BindingDB
IC50=55nM
P50579
Methionine aminopeptidase 2
Oc1ccc(Cl)c2cccnc12
179.606
2.5938
33.12
0
12
1
2
0.674532
6qex
NMR
2,019
CLR
A
1307
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1316
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1305
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1306
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1314
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1313
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1312
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
TA1
A
1320
ic50
=
53,900
nM
-4.268411
BindingDB
IC50=53900nM
P08183
Multidrug resistance protein 1
CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
853.918
3.7357
221.29
10
62
4
14
0.129786
6qex
NMR
2,019
CLR
A
1319
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1309
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qex
NMR
2,019
CLR
A
1304
ic50
=
8,200
nM
-5.086186
BindingDB
IC50=8200nM
P08183
Multidrug resistance protein 1
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
386.664
7.3887
20.23
5
28
1
1
0.488312
6qfe
1.67
2,019
J08
A
305
ic50
=
0.08
uM
-7.09691
MOAD
ic50=0.08uM
Q9Y337,Q9Y337
Kallikrein-5,Kallikrein-5
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qfe
1.67
2,019
J08
B
305
ic50
=
0.08
uM
-7.09691
MOAD
ic50=0.08uM
Q9Y337,Q9Y337
Kallikrein-5,Kallikrein-5
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qff
1.64
2,019
J08
A
301
ic50
=
2.04
uM
-5.69037
MOAD
ic50=2.04uM
Q92876
Kallikrein-6
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qff
1.64
2,019
J08
B
302
ic50
=
2.04
uM
-5.69037
MOAD
ic50=2.04uM
Q92876,Q92876
Kallikrein-6,Kallikrein-6
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qfg
1.68
2,019
J08
A
302
ic50
=
3.01
uM
-5.521434
MOAD
ic50=3.01uM
Q92876
Kallikrein-6
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qfg
1.68
2,019
J08
B
302
ic50
=
3.01
uM
-5.521434
MOAD
ic50=3.01uM
Q92876,Q92876
Kallikrein-6,Kallikrein-6
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qfh
1.65
2,019
J08
A
301
ic50
=
1.38
uM
-5.860121
MOAD
ic50=1.38uM
Q92876,Q92876
Kallikrein-6,Kallikrein-6
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qfh
1.65
2,019
J08
B
303
ic50
=
1.38
uM
-5.860121
MOAD
ic50=1.38uM
Q92876,Q92876
Kallikrein-6,Kallikrein-6
NC(=[NH2+])c1ccc(NCc2ncc(-c3ccccc3)[nH]2)cc1OCc1cccnc1
399.478
2.1272
114.44
8
30
4
4
0.267665
6qfq
1.6
2,019
J3E
A
402
ic50
=
100
nM
-7
BindingDB
IC50=100nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
Cc1n[nH]c(C)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)[O-])[nH]c12
438.507
4.70314
93.83
7
33
2
4
0.360164
6qfq
1.6
2,019
J3E
A
401
ic50
=
100
nM
-7
BindingDB
IC50=100nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
Cc1n[nH]c(C)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)[O-])[nH]c12
438.507
4.70314
93.83
7
33
2
4
0.360164
6qge
1.16
2,019
J1E
A
301
kd
=
0
M
-7.19382
MOAD
Kd=6.4e-08M
P17931
Galectin-3
OC[C@H]1O[C@@H](SC[C@@H](O)Cn2cc(-c3cccc(F)c3)nn2)[C@H](O)[C@@H](n2cc(-c3cccc(F)c3)nn2)[C@H]1O
560.583
1.2562
151.57
9
39
4
12
0.235471
6qgf
1.34
2,019
J0T
A
301
kd
=
0
M
-7.19382
MOAD
Kd=6.4e-08M
P17931
Galectin-3
OC[C@H]1O[C@@H](SC[C@H](O)Cn2cc(-c3cccc(F)c3)nn2)[C@H](O)[C@@H](n2cc(-c3cccc(F)c3)nn2)[C@H]1O
560.583
1.2562
151.57
9
39
4
12
0.235471
6qgp
1.942
2,020
J2E
B
1009
ic50
=
410
nM
-6.387216
BindingDB
IC50=410nM
Q8WQX9
Phosphodiesterase
COc1ccc(C2=NN(C3CCCCCC3)C(=O)C2(C)C)cc1OC1CCCC1
398.547
5.3119
51.13
5
29
0
4
0.631523
6qgv
1.4
2,020
J2H
A
502
ic50
=
0.127
uM
-6.896196
MOAD
ic50=0.127uM
Q9GZT9
Egl nine homolog 1
Cc1cccnc1C[N@H+]1CC[C@@]2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1ncccn1
505.602
3.43792
83.73
5
38
1
5
0.42038
6qhg
1.483
2,019
MGT
A
2001
kd
=
737
uM
-3.132533
MOAD
Kd=737.0uM
A2SZS3
Polymerase
CN1CN([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21
535.192
-5.1722
299.08
8
33
4
18
0.226062
6qhg
1.483
2,019
MGT
B
2001
kd
=
737
uM
-3.132533
MOAD
Kd=737.0uM
A2SZS3
Polymerase
CN1CN([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21
535.192
-5.1722
299.08
8
33
4
18
0.226062
6qi4
1.78
2,019
FKW
B
212
kd
=
43
uM
-4.366532
MOAD
Kd=43.0uM
P62166
Neuronal calcium sensor 1
O=C(Cc1c[nH]c2ccccc12)NN=Cc1ccc([N+](=O)[O-])c(O)c1
338.323
2.4745
120.62
5
25
3
5
0.375747
6qj5
2.0
2,020
H8R
A
501
kd
=
30.1
nM
-7.521434
MOAD
Kd=30.1nM
P37231
Peroxisome proliferator-activated receptor gamma
CCCCCCCCOc1ccc(C(=O)N[C@H](C(=O)[O-])C(C)C)cc1
348.463
2.9302
78.46
12
25
1
4
0.58915
6ql1
1.42
2,019
V50
A
305
kd
=
15
nM
-7.823909
MOAD
Kd=15.0nM
P00918
Carbonic anhydrase 2
Cc1cc(C)nc(Sc2c(F)c(F)c(S(N)(=O)=O)c(F)c2F)n1
367.349
2.44844
85.94
3
23
1
5
0.511627
6ql1
1.42
2,019
V50
A
306
kd
=
15
nM
-7.823909
MOAD
Kd=15.0nM
P00918
Carbonic anhydrase 2
Cc1cc(C)nc(Sc2c(F)c(F)c(S(N)(=O)=O)c(F)c2F)n1
367.349
2.44844
85.94
3
23
1
5
0.511627
6ql2
1.3
2,019
EZL
A
306
kd
=
1.1
nM
-8.958607
MOAD
Kd=1.1nM
P00918
Carbonic anhydrase 2
CCOc1ccc2nc(S(N)(=O)=O)sc2c1
258.324
1.3424
82.28
3
16
1
5
0.900283
6ql3
1.35
2,019
V14
A
302
kd
=
4.5
nM
-8.346787
MOAD
Kd=4.5nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCO)c(NC2CCCCCCC2)c1F
444.497
2.0421
126.56
6
28
3
6
0.576604
6qln
1.0
2,019
J5Q
A
301
kd
=
88
uM
-4.055517
MOAD
Kd=88.0uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4cccc(F)c4)nn3)[C@H]2O)cc1
431.489
2.16502
100.63
5
30
3
8
0.569209
6qlo
1.18
2,019
J5E
A
301
kd
=
92
uM
-4.036212
MOAD
Kd=92.0uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4ccc(F)c(F)c4)nn3)[C@H]2O)cc1
449.479
2.30412
100.63
5
31
3
8
0.549611
6qlp
1.081
2,019
J3Q
A
302
kd
=
22
uM
-4.657577
MOAD
Kd=22.0uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4cc(F)c(F)c(F)c4)nn3)[C@H]2O)cc1
467.469
2.44322
100.63
5
32
3
8
0.495835
6qlq
1.079
2,019
J4E
B
302
kd
=
31
uM
-4.508638
MOAD
Kd=31.0uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4ccc(F)cc4)nn3)[C@H]2O)cc1
431.489
2.16502
100.63
5
30
3
8
0.569209
6qlr
0.97
2,019
J4N
A
301
kd
=
8.8
uM
-5.055517
MOAD
Kd=8.8uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4cc(F)cc(F)c4)nn3)[C@H]2O)cc1
449.479
2.30412
100.63
5
31
3
8
0.549611
6qls
1.047
2,019
HRK
A
301
kd
=
15
uM
-4.823909
MOAD
Kd=15.0uM
P17931
Galectin-3
OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](n2cc(-c3ccccc3)nn2)[C@H]1O
485.515
-2.5417
190.78
6
33
7
13
0.22717
6qlt
1.15
2,019
J5W
A
302
kd
=
23
uM
-4.638272
MOAD
Kd=23.0uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4ccccc4F)nn3)[C@H]2O)cc1
431.489
2.16502
100.63
5
30
3
8
0.569209
6qlu
1.1
2,019
J62
A
301
kd
=
5.2
uM
-5.283997
MOAD
Kd=5.2uM
P17931
Galectin-3
Cc1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](n3cc(-c4ccc(F)c(C)c4)nn3)[C@H]2O)cc1
445.516
2.47344
100.63
5
31
3
8
0.554711
6qmd
1.94
2,019
J6N
A
702
ic50
=
170
uM
-3.769551
MOAD
ic50=170.0uM
Q9Z2X8
Kelch-like ECH-associated protein 1
Cn1nnc2cc([C@H](CC(=O)[O-])c3ccc(Cl)cc3)ccc21
314.752
1.8936
70.84
4
22
0
5
0.737083
6qmd
1.94
2,019
J6N
A
703
ic50
=
170
uM
-3.769551
MOAD
ic50=170.0uM
Q9Z2X8
Kelch-like ECH-associated protein 1
Cn1nnc2cc([C@H](CC(=O)[O-])c3ccc(Cl)cc3)ccc21
314.752
1.8936
70.84
4
22
0
5
0.737083
6qme
1.81
2,019
J6Q
A
702
ic50
=
44
uM
-4.356547
MOAD
ic50=44.0uM
Q9Z2X8
Kelch-like ECH-associated protein 1
Cc1cc([C@H](CC(=O)[O-])c2ccc3c(c2)nnn3C)ccc1Cl
328.779
2.20202
70.84
4
23
0
5
0.735827
6qmj
1.86
2,019
J6K
A
703
ic50
=
0.069
uM
-7.161151
MOAD
ic50=0.069uM
Q9Z2X8
Kelch-like ECH-associated protein 1
COc1cc([C@@H](CC(=O)[O-])c2ccc(C)c(CN(C)S(=O)(=O)c3ccccc3)c2)cc2nnn(C)c12
507.592
2.37792
117.45
9
36
0
8
0.341339
6qmk
1.72
2,019
J8H
A
702
ic50
=
0.047
uM
-7.327902
MOAD
ic50=0.047uM
Q9Z2X8
Kelch-like ECH-associated protein 1
COc1cc([C@@H](CC(=O)[O-])c2ccc(C)c(CN3CCOc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12
535.602
2.14052
126.68
7
38
0
9
0.35233
6qmr
2.0
2,019
J6T
A
301
ic50
=
0.012
uM
-7.920819
MOAD
ic50=0.012uM
P00746
Complement factor D
[NH3+][C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)[O-])c2)c1
377.44
1.5003
97.23
8
28
2
4
0.62162
6qmr
2.0
2,019
J6T
B
301
ic50
=
0.012
uM
-7.920819
MOAD
ic50=0.012uM
P00746
Complement factor D
[NH3+][C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)[O-])c2)c1
377.44
1.5003
97.23
8
28
2
4
0.62162
6qmr
2.0
2,019
J6T
C
301
ic50
=
0.012
uM
-7.920819
MOAD
ic50=0.012uM
P00746
Complement factor D
[NH3+][C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)[O-])c2)c1
377.44
1.5003
97.23
8
28
2
4
0.62162