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39931167 | Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation. | <h4>Purpose</h4>Metformin (Met) is widely used to treat a variety of diseases, but its role in ulcerative colitis (UC) has not been fully elucidated. This study aimed to clarify the effect of Met on UC, exploring its relationship with NLRP3 inflammasome and elucidating the potential mechanisms.<h4>Methods</h4>C57BL/6J ... |
39923376 | Lotus leaf-inspired poly(lactic acid) nanofibrous membranes with enhanced humidity resistance for superefficient PM filtration and high-sensitivity passive monitoring. | The biomimetic design principles offer promising solutions to fabrication of multifunctional nanofibrous membranes (NFMs) with on-demand hierarchies and properties. Herein, a combined electrospinningelectrospray approach was employed to firmly anchor MOF nanocrystals onto poly(lactic acid) (PLA) nanofibers, resembling ... |
39921204 | Multiple Classes of Antigen Contribute to the Antigenic Landscape of Mesothelioma. | Mesothelioma is an incurable, asbestos-exposure-related cancer that typically affects the lining or pleura of the lungs. Symptoms typically develop many decades after initial asbestos exposure, leaving an enduring legacy of disease. The current disease burden is peaking worldwide and thus there is a massive unmet clini... |
39914051 | Single-point mutations in disordered proteins: Linking sequence, ensemble, and function. | Mutations in genomic DNA often result in single-point missense mutations in proteins. For folded proteins, the functional effect of these missense mutations can often be understood by their impact on structure. However, missense mutations in intrinsically disordered protein regions (IDRs) remain poorly understood. In I... |
39911887 | Crystallographic and computational characterization and <i>in silico</i> target fishing of six aromatic and aliphatic sulfonamide derivatives. | The molecular and crystal structures of six compounds containing sulfonamide moieties are described. It has been shown that the geometric parameters of the sulfonamide group depend little on the nature of the substituents. Their bond lengths and bond angles remain almost the same and are in good accordance with those k... |
39910924 | Metal-Organic Framework-Based Tribovoltaic Textile for Human Body Signal Monitoring. | The pursuit of sustainable and portable direct current (DC) energy suppliers has ignited considerable interest in tribovoltaic nanogenerators (TVNGs), devices that harvest mechanical energy from the surrounding environment. However, the predominant focus in TVNG research has centered on rigid and silicon-based semicond... |
39910866 | Highly Selective Ethylene/Ethane Separation in MOF Composites through Pore Contraction and Particle Size Enlargement Strategy. | The discrimination of ethylene (C<sub>2</sub>H<sub>4</sub>) and ethane (C<sub>2</sub>H<sub>6</sub>) by the precise regulation of porous materials is important and challenging. In this work, the quasi-exclusion of C<sub>2</sub>H<sub>6</sub> from C<sub>2</sub>H<sub>4</sub> is realized through a facile polymer modificatio... |
39910856 | Palladium Nanocubes with {100} Facets for Hydrogen Evolution Reaction: Synthesis, Experiment and Theory. | Spatially separated palladium nanocubes (Pd NCs) terminated by {100} facets are synthesized using direct micelles approach. The stepwise seed-mediated growth of Pd NCs is applied for the first time. The resulting Pd NCs are thoroughly characterized by HR-TEM, XPS, Raman, ATR-FTIR, TGA, and STEM-EDX spectroscopies. Some... |
39910852 | Nanobody-Mediated Cellular Uptake Maximizes the Potency of Polylysine Dendrimers While Preserving Solid Tumor Penetration. | Dendrimers are branched macromolecular structures that are useful nanocarriers for small-molecule drugs, such as cancer therapeutics. Their small size permits penetration into solid tumors, coupled with functionalization with a low-fouling PEG coating that minimizes transient cellular interactions and enhances plasma c... |
39910842 | Tailored Supramolecular Additives to Control the Crystallization Process and Morphology of MAPbI<sub>3</sub>. | Perovskite films feature unique optoelectronic properties, rendering them promising for electronic devices. The properties depend on the morphology on a broad range of length scales from nanometers to millimeters, influenced by a variety of factors. However, controlling the morphology is challenging. A tailored supramo... |
39910837 | Lyotropic Liquid Crystal Mediated Assembly of Donor Polymers Enhances Efficiency and Stability of Blade-Coated Organic Solar Cells. | Conjugated polymers can undergo complex, concentration-dependent self-assembly during solution processing, yet little is known about its impact on film morphology and device performance of organic solar cells. Herein, lyotropic liquid crystal (LLC) mediated assembly across multiple conjugated polymers is reported, whic... |
39910832 | Glucuronidase-Instructed Glycopeptide Self-Assembly for Selective Killing of Cancer Cells through Lysosomal Membrane Permeabilization. | Current cancer treatments face significant challenges, including limited tumor specificity and drug resistance. Enzyme-instructed supramolecular peptide assembly targeting lysosomes offers a promising strategy to address these issues; however, self-assembling units that withstand lysosomal conditions are still scarce. ... |
39910471 | Development and evaluation of a novel E7 multi-epitopic vaccine for human papillomavirus type 16: design, expression, purification, and immunological characterization. | <h4>Background</h4>Persistent infection with high-risk Human papillomavirus (HPV), specifically HPV-16, is the leading cause of cervical cancer. Although preventative vaccines have shown significant efficacy in preventing HPV infection, cervical cancer is a significant public health issue that affects millions of women... |
39910410 | Control the Gene Delivery and Anticancer Efficacy of Peptides through Chiral Modulation. | Incorporating d-amino acids into peptides can influence the intermolecular interactions of peptides, thus determining the morphology and functionality of self-assembled supramolecular structures. Based on this, we propose a modular chirality regulation strategy and designed four chiral peptides by adjusting the chirali... |
39910400 | Self-Cleaning Antifouling Membrane Engineered by Oxygen-Activated MOF-Derived Catalysts for Efficient Organic Wastewater Treatment. | Utilizing membrane separation technology has displayed promising application potential for removing synthetic dyes; however, membrane performance tends to decline over time due to fouling caused by feed solution contaminants, leading to decreased separation efficiency and shortened membrane lifespan. Therefore, improvi... |
39910312 | Metal-halide porous framework superlattices. | The construction of superlattices with a spatial modulation of chemical compositions allows for the creation of artificial materials with tailorable periodic potential landscapes and tunable electronic and optical properties<sup>1-5</sup>. Conventional semiconductor superlattices with designable potential modulation in... |
39910310 | H-bonded organic frameworks as ultrasound-programmable delivery platform. | The precise control of mechanochemical activation within deep tissues using non-invasive ultrasound holds profound implications for advancing our understanding of fundamental biomedical sciences and revolutionizing disease treatments<sup>1-4</sup>. However, a theory-guided mechanoresponsive materials system with well-d... |
39910154 | Innovative zero-valent cobalt decoration on MIL-88 A(Fe)@β-CD for high-efficiency and reusable cr(VI) removal. | Herein, the magnetic ZVCo-MIL-88 A(Fe)@β-CD composite was fabricated via post-synthetic decoration of MIL-88 A(Fe)@β-CD with ZVCo to produce a magnetic efficient adsorbent for Cr(VI) removal. The experimental findings denoted that the ZVCo decoration boosted the adsorption capability of MIL-88 A(Fe)@β-CD, where the ads... |
39910128 | Guest-induced structural transformation of single-crystal 3D covalent organic framework at room and high temperatures. | Soft porous crystals, recognized as the third generation of smart porous materials, can undergo structural deformations in response to external stimuli, such as temperature, pressure, and guest molecules. Currently, the dynamic phase transformations of soft porous crystals are predominantly determined through quantitat... |
39910113 | Optimization and modeling of sulfur removal from liquid fuel using carbon-based adsorbents through synergistic application of RSM and machine learning. | This research investigates the adsorption desulfurization of liquid fuels using artificial neural networks (ANN) and response surface methodology (RSM) approaches. The effectiveness of sulfur removal was predicted by analyzing five important factors: temperature, concentration, surface area, fuel/adsorbent, and time. W... |
39910105 | Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage. | Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in cancer remains unclear despi... |
39910090 | Novel Azo dyes containing a hydrazide-hydrazone moiety for dyeing polyester fabric. | Novel azo dyes containing a hydrazide-hydrazone moiety linked to the benzothiazole nucleus are synthesized effectively in this study. The primary purpose of the study was to identify the best dyeing parameters, such as shade, temperature, pH, and time, in order to better understand the behaviour of dispersed dyes durin... |
39909958 | Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, and targeted therapies. This approach harnesses the body's immune system to ta... |
39909401 | Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy. | Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered <b>RFYFYR-Ce6-RFYFYR (R-Ce6-R)</b>, a twin-tail peptide-photosensitizer conjugate that self-assembles into nanostructures for imp... |
39908572 | MXene Membranes Inserted with Tannic Acid Etched MOF Nanocrystals for Ultrafast Water Permeation: Elucidating the Water Transport Mechanism in Nanoconfined Interlaminar Channels. | Utilizing pore and interlayer engineering within nanoconfined interlaminar channels represents an ingenious approach to design highly permselective MXene (Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub>) membranes. Herein, the tannic acid (TA) etched ZIF-8 (TZIF-8) nanocrystals with hollow structures were effectually inserted... |
39908571 | Tetrafluororesorcin[4]arene Hexameric Capsule Enables the Expansion of the Reactivity Space in Supramolecular Catalysis. | This study presents the development and catalytic applications of the tetrafluororesorcin[4]arene hexameric capsule (capsule II) as a novel supramolecular catalyst. It demonstrates unprecedented catalytic activity, enabling the β-selective glycosylation of glycals to 2-deoxy glycosides─a transformation that has not bee... |
39908554 | Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing. | Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility to bacterial infection. In this study, we developed a dual ROS/glucose-responsive ... |
39908463 | Apolipoprotein Fusion Enables Spontaneous Functionalization of mRNA Lipid Nanoparticles with Antibody for Targeted Cancer Therapy. | The mRNA-lipid nanoparticles (mRNA@LNPs) offer a novel opportunity to treat targets previously considered undruggable. Although antibody conjugation is crucial for enhancing the specificity, delivery efficiency, and minimizing the toxicity of mRNA therapeutics, current chemical conjugation methods are complex and produ... |
39908383 | Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria. | Intracellular bacterial infections and antimicrobial resistance are threatening global public health systems. Antimicrobial peptides are a potential solution to combat bacterial resistance, but the design of self-assembled nanopeptides with dual functions of cell penetration and antibacterial properties to combat intra... |
39908381 | Emergent complexity of quantum rotation tunneling. | Conformational isomerism determines the performance of materials and the activity of biomolecules. However, a complete dynamic study of conformational isomerization is still a formidable challenge at the single-molecule level. In this work, we present real-time in situ electrical monitoring of the full rotation dynamic... |
39908288 | Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. | Since the emergence of SARS-CoV-2 and the COVID-19 pandemic, a wide range of treatment options have been evaluated in preclinical studies and clinical trials, with several being approved for use in humans. Immunomodulatory drugs have shown success in dampening the deleterious inflammatory response seen in severe COVID-... |
39908250 | Insilico targeting of virus entry facilitator NRP1 to block SARS-CoV2 entry. | The entry and infectivity of a virus are determined by its interaction with the host. SARS-CoV-2, the virus responsible for COVID-19, utilizes the spike (S) protein to attach to and enter host cells. Recent studies have identified neuropilin-1 (NRP1) as a crucial facilitator for the entry of SARS-CoV-2. The binding of ... |
39908231 | Sialylation Shields Glycoproteins from Oxidative Stress: Mechanistic Insights into Sialic Acid Oxidation and Structural Stability. | Sialylation, a crucial yet labile protein modification, is increasingly recognized for its role in modulating protein structure, function, and stability. While the impact of oxidative stress on protein integrity is well-established, the protective role of sialylation against such damage remains poorly understood. This ... |
39908165 | Tailoring Tumor Cell Golgi Apparatus-Targeting Self-Assembled Peptide for Effective Immunotherapy via Reshaping MIF-Mediated Immunosuppressive Network. | The immunosuppressive network formed by the enhanced crosstalk between tumor cells and various types of immune cells may ultimately lead to the formation of tumor immunosuppressive microenvironment (TIME). The Golgi apparatus (GA) of tumor cells is a key organelle in the formation of a tumor immunosuppressive network. ... |
39908164 | Mechanism of Hydrogen Generation Catalyzed by a Single Atom and Its Spin Regulation. | Single-atom catalysts exhibit the excellent catalytic activity and selectivity, making them widely applicable in the fields of advanced materials, environmental science, and chemical synthesis. However, understanding the mechanism of single-atom catalytic reactions, such as the hydrogen generation reaction, is still ch... |
39908124 | Periodic GFN1-xTB Tight Binding: A Generalized Ewald Partitioning Scheme for the Klopman-Ohno Function. | A novel formulation is presented for the treatment of electrostatics in the periodic GFN1-xTB tight-binding model. Periodic GFN1-xTB is hindered by the functional form of the second-order electrostatics, which only recovers Coulombic behavior at large interatomic distances and lacks a closed-form solution for its Fouri... |
39908103 | Synergistic anion-π interactions in peptidomimetic polyethers. | Anion-π interactions are crucial in various biological processes, such as enzyme catalysis and ion transport. Despite their significance, the exploitation of anion-π interactions in synthetic polymer systems remains underexplored. This study investigates anion-π interactions using chemically well-defined peptidomimetic... |
39908079 | An S-Scheme MOF-on-MXene Heterostructure for Enhanced Photocatalytic Periodate Activation. | Fully understanding the periodate (PI) activation system is still a great challenge, which calls for efficient heterogeneous catalysts with a sophisticated structure. Herein, we developed "MOF-on-MXene" heterostructures. By constructing S-scheme heterostructures MXene/Z67<sub>450</sub>, the internal electric field is g... |
39908032 | Glycan-Silica Nanoparticles as Effective Inhibitors for Blocking Virus Infection. | Small solid silica nanoparticles (SiNPs) have been used for multivalent carbohydrate presentation in DC-/L-SIGN-mediated viral infection models. Glycosylated SiNPs (glycoSiNPs) were fully characterized by different experimental techniques, including NMR, DLS, TGA, FTIR, and XPS, which confirmed their chemical structure... |
39908016 | Hexaazatrinaphthylene-Based Ultrastable Metal-Organic Frameworks Modulated by the Chelating Coordination Configuration for CO<sub>2</sub> Capture. | Hexaazatrinaphthylene (HATN), a polyheterocyclic aromatic ligand, is ideal for constructing discrete functional coordination complexes. However, its conjugated rigidity has resulted in a great challenge in forming extended structures with only one 3D metal-organic framework (MOF) reported 24 years ago. Herein, by regul... |
39907951 | Herbal remedies for oral and dental health: a comprehensive review of their multifaceted mechanisms including antimicrobial, anti-inflammatory, and antioxidant pathways. | Across diverse cultures, herbal remedies have been used to alleviate oral discomfort and maintain dental hygiene. This review presents studies on herbal remedies with remarkable antimicrobial, anti-inflammatory, antioxidant, anticancer, anticaries, analgesic, and healing properties. The manuscripts demonstrate the dept... |
39907892 | Functionalized Separators Boosting Electrochemical Performances for Lithium Batteries. | The growing demands for energy storage systems, electric vehicles, and portable electronics have significantly pushed forward the need for safe and reliable lithium batteries. It is essential to design functional separators with improved mechanical and electrochemical characteristics. This review covers the improved me... |
39907797 | Development and evaluation of [<sup>11</sup>C]DPA-813 and [<sup>18</sup>F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971. | <h4>Purpose</h4>The translocator protein 18 kDa (TSPO) is a widely used marker for imaging neuroinflammation via Positron Emission Tomography (PET). However, the vast majority of reported TSPO PET tracers display low binding affinity to a common isoform of human TSPO (rs6971; A147T), making them unsuitable for universa... |
39907698 | Therapeutic Potential of Arimoclomol Nanomicelles: In Vitro Impact on Alzheimer's and Parkinson's Pathology and Correlation with In Vivo Inflammatory Response. | This study investigates the potential of arimoclomol-loaded nanomicelles for the treatment of neurodegenerative diseases like Alzheimer's and Parkinson's, as well as their anti-inflammatory properties. Arimoclomol, a coinducer of heat shock proteins (HSPs), has shown clinical promise in mitigating protein misfolding, a... |
39907636 | Electrospinning of Self-Assembling Oligopeptides into Nanofiber Mats: The Impact of Peptide Composition and End Groups. | Low-molecular-weight oligopeptides can be electrospun into nanofiber mats. However, the mechanism underlying their electrospinnability is not well-understood. In this study, we used solid-phase peptide synthesis to produce the oligopeptide FFKK, to which the aromatic end-capping groups naphthalene, pyrene, and tetraphe... |
39907634 | Toward the Prediction of Binding Events in Very Flexible, Allosteric, Multidomain Proteins. | Knowledge of the structures formed by proteins and small molecules is key to understand the molecular principles of chemotherapy and for designing new and more effective drugs. During the early stage of a drug discovery program, it is customary to predict ligand-protein complexes in silico, particularly when screening ... |
39907522 | Polydopamine-Mediated Nanofillers Reinforced Zwitterion Hydrogel Electrodes for Supercapacitors in Bioelectronics. | Supercapacitors that can function when in direct contact with human tissue are of paramount importance for wearable bioelectronics but face mismatching with biological tissue and its movement. Herein, we developed a zwitterion hydrogel elastomer electrode-based all-hydrogel supercapacitor (AHSC) characterized by good e... |
39907440 | Simulation Study of the Water Ordering Effect of the β-(1,3)-Glucan Callose Biopolymer. | Callose, a polysaccharide closely related to cellulose, plays a crucial role in plant development and resistance to environmental stress. These functions are often attributed to the enhancement by callose of the mechanical properties of semiordered assemblies of cellulose nanofibers. A recent study, however, suggested ... |
39907281 | The Japanese encephalitis virus NS1 protein concentrates ER membranes in a cytoskeleton-independent manner to facilitate viral replication. | Orthoflaviviruses remodel the endoplasmic reticulum (ER) network to construct replication organelles (ROs) for RNA replication. In this study, we demonstrate that the Japanese encephalitis virus (JEV) NS1 protein concentrates ER membranes in the perinuclear region, which provides a substantial membrane source for viral... |
39907282 | Class B scavenger receptor resists WSSV replication by recognizing the viral lipid molecule and promoting phagocytosis. | Class B scavenger receptors (SRBs) have been well-studied in bacteria-induced immune responses in invertebrates. However, the status of SRB-defending viruses remains unclear. In this study, we identified a scavenger receptor in <i>Procambarus clarkii</i> (crayfish), which is homologous to mammalian SRBs, and designated... |
39907268 | Chemistry Meets Plasmon Polaritons and Cavity Photons: A Perspective from Macroscopic Quantum Electrodynamics. | The interaction between light and molecules under quantum electrodynamics (QED) has long been less emphasized in physical chemistry, as semiclassical theories have dominated due to their relative simplicity. Recent experimental advances in polariton chemistry highlight the need for a theoretical framework that transcen... |
39907121 | Anion-Guided Hierarchical Assembly of Heterometallic Clusters. | Anions are important as templates for the construction of many structurally sophisticated and functional supramolecular architectures. Deciphering the specific role of such templates remains a great challenge due to the unique characteristics of anions. Herein, three heterometallic Ce-Ni clusters, namely, [Ce<sub>24</s... |
39906911 | Sequential Stimuli-Response System of Eu-MOF Isomers. | Multiple stimuli-responsive materials hold excellent potential for the next generation smart materials owing to their unique response to external stimuli, providing a powerful impetus for the development of intelligent optical devices. The stimuli-responsive behavior of common multiple stimuli-responsive materials are ... |
39906017 | Evolution and Reconstruction of Air-Electrode Surface Composition in Reversible Protonic Ceramic Cells: Mechanisms, Impacts on Catalytic Performance, and Optimization Strategies - A Review. | Reversible protonic ceramic cells (R-PCCs) are at the forefront of electrochemical conversion devices, capable of reversibly and efficiently converting chemical energy into electricity at intermediate temperatures (350-700 °C) with zero carbon emissions. However, slow surface catalytic reactions at the air-electrode of... |
39906007 | In Situ Coordinated MOF-Polymer Composite Electrolyte for Solid-State Lithium Metal Batteries with Exceptional High-Rate Performance. | The integration of metal organic frameworks (MOFs) and electrospun polymer fibers offers the potential to achieve uniform dispersion and high loading of fillers, providing a unique perspective for advancing composite solid electrolytes in solid-state lithium metal batteries. In this work, a composite solid electrolyte ... |
39905995 | How We Simulate DNA Origami. | DNA origami consists of a long scaffold strand and short staple strands that self-assemble into a target 2D or 3D shape. It is a widely used construct in nucleic acid nanotechnology, offering a cost-effective way to design and create diverse nanoscale shapes. With promising applications in areas such as nanofabrication... |
39905990 | Antimicrobial Phenolic Materials: From Assembly to Function. | Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug-resistant pathogens that globally cause high mortality rates. These pathogens can persist on surfaces and spread in public and healthcare settings. Advances have been made in developing antimicrobial materials to ... |
39905976 | A Potential 3-in-1 Combined AntiSARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation. | The emergence and rapid propagation of infectious diseases, including the COVID-19 pandemic, has evidenced the vulnerabilities in global health surveillance, the ease of transmission, and the imperative need for effective treatments. In this context, nanomedicines based on metal-organic frameworks (MOFs) have garnered ... |
39905964 | Covalent Dynamic DNA Networks to Translate Multiple Inputs into Programmable Outputs. | Inspired by naturally occurring protein dimerization networks, in which a set of proteins interact with each other to achieve highly complex input-output behaviors, we demonstrate here a fully synthetic DNA-based dimerization network that enables highly programmable input-output computations. Our DNA-based dimerization... |
39905963 | From natural defenders to therapeutic warriors: NK cells in HIV immunotherapy. | Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells both play essential roles in controlling viral infections by eliminating virus-infected cells. Unlike CTLs, which require priming and activation by antigen-presenting cells, NK cells possess a remarkable capacity to mount a rapid antiviral immune response imm... |
39905957 | Dual-Action NO Delivery from One Mixed Metal Metal-Organic Framework. | Owing to their varied and controllable reticular chemistry, metal-organic frameworks (MOFs) represent excellent, structurally precise material platforms for creating multifunctional devices. This flexibility allows the design of MOFs to feature two different delivery mechanisms for the medicinal gas nitric oxide (NO) w... |
39905926 | Biological Polymers: Evolution, Function, and Significance. | A holistic description of biopolymers and their evolutionary origins will contribute to our understanding of biochemistry, biology, the origins of life, and signatures of life outside our planet. While biopolymer sequences evolve through known Darwinian processes, the origins of the backbones of polypeptides, polynucle... |
39905919 | Cyanide Functionalization and Oxygen Vacancy Creation in Ni-Fe Nano Petals Sprinkled with MIL-88A Derived Metal Oxide Nano Droplets for Bifunctional Alkaline Seawater Electrolysis. | This work investigates novel improvements in FeNi-layered double hydroxide (LDH)/MIL-88A heterocomposite for sustainable seawater electrolysis through a single-step dual functionalization process. The Fe/Ni precursor weight ratio is optimized, resulting in the formation of smaller LDH petals and nano-sized MIL-88A meta... |
39905876 | Size-Tunable Covalent Organic Framework Nanoparticles for Assembling One-Dimensional Photonic Crystals With Visual Sensing. | One-dimensional photonic crystals (1D PCs) emerged as superb sensing platforms due to their high sensitivity to environmental changes. However, effectively translating the microscopic interactions between covalent organic frameworks (COFs) and analytes into macroscopic optical responses via 1D PCs for intuitive detecti... |
39905842 | Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome. | <h4>Background/aims</h4>Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone demethylases to regulate gene expression through histone me... |
39905515 | Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus. | <h4>Background</h4>The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. The limited number of established targets further restricts the identification of novel antibiotics to treat life-threatening MDR infections... |
39902629 | Spatial Confinement of a Dual Activatable DNAzyme Sensor in the Cavity of a DNA Nanocage for Logic-Gated Molecular Imaging. | Despite intense interest in design of DNAzyme sensors for molecular detection and imaging in living cells, their intracellular applications are still hampered by limited spatial control and poor bio-stability. Here we present controlled spatial confinement of a rationally designed, microRNA (miRNA)-activatable DNAzyme ... |
39876816 | pH-Controlled DNA Switching Circuits with Multi-State Responsiveness for Logic Computation and Control. | Dynamic control of DNA circuit functionality is essential for constructing chemical reaction networks (CRNs) that implement complex functions. The triplex has been utilized for dynamically regulating the diverse functionalities of DNA circuits due to its distinctive pH responsiveness. However, it is challenging for tri... |
39868966 | Controlled Self-assembly of Nanographdiynes Mediated by Molecular Dipoles Induced by Rotatory Asymmetric Substituents. | The discrete π- stacks of specific lengths and orientation is crucial for understanding the impact of intermolecular interactions on optical or electronic properties of nanographdiynes. We designed and synthesized nanographdiynes modified with bulky rotatable asymmetric substituents. The peripheral substituents with di... |
39865453 | Polymer Ligands with Multi-Nitrogen Heterocyclic Carbenes for Enhanced Stability and Reactivity in Nanoparticle Surface Functionalization. | Nitrogen heterocyclic carbenes (NHCs) are emerging as effective substitutes for conventional thiol ligands in surface functionalization of nanoparticles (NPs), offering exceptional stability to NPs under harsh conditions. However, the highly reactive feature of NHCs limits their use in introducing chemically active gro... |
39854016 | Coordination Self-Assembly Induced Hot Exciton Fluorescence and Multi-Source Excitation Long Afterglow. | Metal-organic complexes with long afterglow luminescence have attracted extensive attention due to potential applications in display, sensing and information security. However, most of the metal-organic complex long afterglow materials reported so far are limited to the use of UV light as the excitation source, and the... |
39844689 | Crystalline, Porous Figure-Eight-Noded Covalent Organic Frameworks. | Figure-eight macrocycles represent a fascinating class of π-conjugated units characterized by unique aesthetics and non-contact molecular crossing at the center. Despite progress in synthesis over the past century, research into inorganic, organic, and polymeric figure-eight materials remains in its infancy. Here we re... |
39841627 | Ion Mobility Mass Spectrometry to Probe Sequences in Supramolecular Copolymers. | The analysis of the microstructure of supramolecular copolymers is difficult because of their dynamic character. Here, benzene-1,3,5-tricarboxamide (BTA) co-assemblies are analysed by ion mobility - mass spectrometry (IM-MS) to reveal the presence of various sequences. For example, the IM-MS mobilogram for hexamers com... |
39840800 | Dynamics of Pyrene Excimer in a Cholesteryl-Based Supramolecular Host Matrix. | Aggregation-caused quenching (ACQ) reduces luminescence and compromises brightness in solid-state displays, necessitating strategies to mitigate its effects for enhanced performance. This study presents cost-effective method to mitigate ACQ of pyrene by co-assembling polycyclic aromatic hydrocarbons within low molecula... |
39840440 | Unlocking Advanced Architectures of Single-Crystal Metal-Organic Frameworks. | The synthesis of metal-organic frameworks (MOFs) with diverse geometries has captivated considerable interest due to their manifestation of novel and extraordinary properties. While much progress has been made in shaping regular polyhedral single-crystal MOFs, the creation of more complex, topologically intricate nanos... |
39835455 | Super Strong Bonding at the Interface between ETL and Perovskite for Robust Flexible Optoelectronic Devices. | Organic-inorganic hybrid perovskites have demonstrated great potential for flexible optoelectronic devices due to their superior optoelectronic properties and structural flexibility. However, mechanical deformation-induced cracks at the buried interface and delamination from the substrate severely constrain the optoele... |
39829210 | Modular addition strategy-regulated polymerization-induced self-assembly: an <i>in silico</i> experiment. | We propose a modular addition strategy-regulated polymerization-induced self-assembly (PISA) system to effectively control the reaction kinetics and self-assembly morphologies. We validated this strategy by performing <i>in silico</i> experiments on a well-established PISA system. Two categories of modular addition str... |
39825671 | Anion-π Interactions on Functionalized Porous Aromatic Cages for Gold Recovery from Complex Aqueous with High Capacity. | High capacity, selective recovery and separation of precious metals from complex aqueous solutions is essential but remains a challenge in practical applications. Here, we prepared a thiophene-modified aromatic porous organic cage (T-PAC) with high stability for precise recognition and recovery of gold. T-PAC exhibits ... |
39820268 | Dynamical arrest for globular proteins with patchy attractions. | Attempts to use colloid science concepts to better understand the dynamic properties of concentrated or crowded protein solutions are challenging due to the fact that globular proteins generally have heterogeneous surfaces that result in anisotropic or patchy contributions to their interaction potential. This is partic... |
39807834 | A dendritic drug-drug conjugate self-assembled hypoxia-responsive supramolecular nanoparticle for combination therapy. | Hypoxia, a condition that enhances tumor invasiveness and metastasis, poses a significant challenge for diverse cancer therapies. There is a pressing demand for hypoxia-responsive nanoparticles with integrated photodynamic functions in order to address the aforementioned issues and overcome the reduced efficacy caused ... |
39774563 | Injectable biocompatible hydrogels with tunable strength based on crosslinked supramolecular polymer nanofibers. | Hydrogels based on supramolecular assemblies offer attractive features for biomedical applications including injectability or versatile combinations of various building blocks. We here investigate a system combining benzenetrispeptides (BTP), which forms supramolecular fibers, with polymer polyethylene oxide (PEO) form... |
39760488 | Biological activation of Fenton reaction in polymeric nanoreactors driven by ferrocene-containing membranes: a microenvironment dependent study. | Nanocatalytic medicine for treating cancer requires effective, versatile and novel tools and approaches to significantly improve the therapeutic efficiency for the interactions of (non-)enzymatic reactions. However, it is necessary to develop (non-)enzymatic nanotechnologies capable of selectively killing tumour cells ... |
39714135 | Development of urea-bridged cyclic dominant negative pneumococcus competence-stimulating peptide analogs. | Cyclization is a widely used approach to exert conformational restraint on linear peptide sequences. Herein, urea bridge chemistry was deployed to achieve side chain-to-side chain peptide cyclization on the <i>Streptococcus pneumoniae</i> CSP1-E1A peptide scaffold. To determine the effects of ring size and bridge posit... |
39644128 | Regioselective Dimerization of Methylcyclopentadiene inside Cucurbit[7]uril. | The molecular confinement within rigid macrocyclic receptors can trigger catalytic activity and steer the selectivity of organic reactions. In this work, the dimerization of methylcyclopentadiene (MCPD) isomers in the presence of cucurbit[7]uril (CB7) was found to display, besides a large rate acceleration, a striking ... |
39592233 | Epitope Tagging with Genome Editing in Mice Reveals That the Proton Channel OTOP1 Is Apically Localized and Not Restricted to Type III "Sour" Taste Receptor Cells. | The gustatory system allows animals to assess the nutritive value and safety of foods prior to ingestion. The first step in gustation is the interaction of taste stimuli with one or more specific sensory receptors that are generally believed to be present on the apical surface of the taste receptor cells. However, this... |
39585750 | Versatile, Extrudable and Luminescent Tripodal BTA-Terpyridine (tpy) Gel Cross-Linked with d- and f-Block Metal Ions. | The low molecular weight gelator (LMWG) 1 based on the tripodal benzene-1,3,5-tricarboxamide (BTA) motif, capped with terpyridine (tpy) units, was shown to form supramolecular gels with versatile functionalities such as self-healing, while the cross-linking of its fibers with d- and f-block metal ions led to modified p... |
39429102 | Water-Soluble Curcumin Derivatives Including Aza-Crown Ether Macrocycles as Enhancers of Their Cytotoxic Activity. | The synthesis of three novel curcumin derivative compounds, featuring aza-crown ether macrocycles of various sizes (aza-12-crown-4, aza-15-crown-5, and aza-18-crown-6), is described. The incorporation of these aza-crown macrocycles significantly enhances their water solubility, positioning them as groundbreaking instan... |
40395759 | Hydrovoltaic Power Generation Depend on Wettability at the Liquid-Solid Interface: Mechanisms, Materials, and Applications With Various Resource. | With the global increase in energy consumption, there is a growing demand for green energy production, which has prompted the development of novel renewable energy sources. Recently, significant momentum has been observed in research on new energy harvesting methods suitable for small devices. In this context, hydrovol... |
40385958 | Nonuniform Chiralization of Metal-Organic Frameworks Using Imine Chemistry. | Homochiral metal-organic frameworks (MOFs) are exceptional media for heterogeneous enantiodifferentiation processes. Modifying available achiral structure-bearing MOF scaffolds is a preferred method to extend this class of materials. Reported postsynthetic covalent chiralizations generally lead to uniform, site-specifi... |
40314004 | A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the UiO-66 metal organic framework-graphene oxide nanocomposite. | <h4>Background and purpose</h4>Dopamine has an impact on the cardiovascular, endocrine, renal, and central neurological systems. Electrochemical techniques are becoming more and more popular among researchers as a way to assess dopamine and uric acid levels.<h4>Experimental approach</h4>Using electrochemical techniques... |
40265075 | Imaging antigen processing and presentation in cancer. | <h4>Introduction</h4>Antigen processing and presentation are vital processes of the adaptive immunity. These processes involve a series of intracellular and extracellular events, including the enzymology within cells during antigen processing, the loading and presentation of antigenic peptides on major histocompatibili... |
40230622 | Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery. | This study delves into the impact of two synthetic non-natural amino acids, <b>7</b> and <b>8</b>, on the structural dynamics of serum albumin and their potential significance in anticancer drug delivery systems. Crucially, the dihydrofuran-containing compound <b>7</b> has been identified to bind to the G-quadruplex (G... |
40182659 | Recent advances in nanomaterials and their mechanisms for infected wounds management. | Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with the increasing prevalence of antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due to limited penetration, resistance development, and inadequate local concentration at w... |
40060197 | Molecular biophysics and inhibition mechanism of influenza virus A M2 viroporin by adamantane-based drugs - Challenges in designing antiviral agents. | The influenza A matrix 2 (AM2) protein is a prototype viroporin that conducts protons through an array of water molecules and sidechains of ionizable amino acid residues, with His37 being the most important. Amantadine is a prototype AM2 channel blocker and inhibitor of influenza A AM2 wild type (serine-31) replication... |
40037729 | Human bio-electric generator: Self-powered cellulose-based wearable sensor with ultra-stretchability and low-grade body heat harvesting. | Integrating ultra-stretchability to adapt seamlessly to human movement, while ensuring complete independence from external power sources, presents a substantial challenge for the development of advanced bioelectronic systems. This challenge becomes even more critical as the demand for wearable technologies that can bot... |
40028357 | A Collagen Triple Helix without the Superhelical Twist. | Collagens are ubiquitous in biology: functioning as the backbone of the extracellular matrix, forming the primary structural components of key immune system complexes, and fulfilling numerous other structural roles in a variety of systems. Despite this, there is limited understanding of how triple helices, the basic co... |
40026631 | Lymph node-targeted delivery of <i>Lonicera japonica</i> thunb. polysaccharides for enhancing antitumor immunotherapy. | Dendritic cells (DCs) are crucial for the initiation and regulation of innate and adaptive immunity. Their maturity and infiltration in the tumor largely determine the efficiency of antigen presentation, the CTL responses, and the prognosis of tumors. However, the application of common immunoregulatory plant polysaccha... |
40026627 | Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head. | Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application of 3D printing in addressing the challenges of osteonecrosis of the femoral head... |
40026626 | Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. | Pancreatic ductal adenocarcinoma (PDAC) remains one of the most feared diseases worldwide owing to its poor prognosis, negligible therapeutic advances, and high mortality. Herein, multifunctional enzyme-responsive micelles for the controlled delivery of paclitaxel (PTX) were prepared to circumvent its current clinical ... |
40026622 | Spinal cord injury repair based on drug and cell delivery: From remodeling microenvironment to relay connection formation. | Spinal cord injury (SCI) presents a formidable challenge in clinical settings, resulting in sensory and motor function loss and imposing significant personal and societal burdens. However, owning to the adverse microenvironment and limited regenerative capacity, achieving complete functional recovery after SCI remains ... |
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