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39899724 | Translation elongation defects activate the <i>Caenorhabditis elegans</i> ZIP-2 bZIP transcription factor-mediated toxin defense. | The <i>Caenorhabditis elegans</i> bZIP transcription factor ZIP-2 is activated by toxins or mutations that inhibit translational elongation. The <i>zip-2</i> DNA-binding protein is encoded in a downstream main open reading frame (mORF), but under normal translation elongation conditions only an upstream overlapping oOR... |
39899680 | Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion. | The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark of cancer. Antitumor immunity refers to the innate and adaptive immune responses that regulate cancer development and proliferation. Tumor immune evasion represents a major hindrance to effective anticancer treatment. E... |
39899617 | Powering the Future: Opportunities and Obstacles in Lead-Halide Inorganic Perovskite Solar Cells. | Efficiency, stability, and cost are crucial considerations in the development of photovoltaic technology for commercialization. Perovskite solar cells (PSCs) are a promising third-generation photovoltaic technology due to their high efficiency and low-cost potential. However, the stability of organohalide perovskites r... |
39899608 | Fabrication of Graphene Polyhedra: Unveiling New Structures, Forms, and Properties. | A hybrid nanoporous carbon alloy material is synthesized using a core-shell structure based on metal-organic frameworks, revealing a novel graphene polyhedral form. The presence of carbon and metal as doped cobalt carbides based on morphed graphene within the graphene polyhedra is confirmed through a combination of X-r... |
39899432 | Modular Assembly of Chalcones, <i>N-</i>Tosylhydrazones, and KSCN/KSeCN for the Synthesis of Trisubstituted Imidazo[2,1-<i>b</i>][1,3,4]thiadiazoles/selenadiazoles. | A modular protocol that achieved the efficient synthesis of imidazo[2,1-<i>b</i>][1,3,4]thiadiazoles/selenadiazoles via using easily available <i>N</i>-tosylhydrazones, chalcone derivatives, and KSCN/KSeCN is proposed. The method overcomes the elongated synthesis steps and prefunctionalized synthons of previous methods... |
39899431 | Oriented PolyMOFs Enabled by Bridging Coligand for CO<sub>2</sub> Separation. | Despite enormous research efforts in recent years, polymer-metal-organic framework (polyMOF) development still faces several drawbacks, such as the substantial decrease in surface area, poor crystallinity, and monophyletic chemical structure of polyMOFs. Herein, we overcome the constraints of the coordination mode of c... |
39899426 | Synthesis and Structure of Pillar[<i>m</i>]arene[1]phthalimide and Pillar[<i>m</i>]arene[1]naphthalimide. | A series of monofunctionalized pillar[<i>n</i>]arenes skeleton macrocycles pillar[<i>m</i>]arene[1]phthalimide and pillar[<i>m</i>]arene[1]naphthalimide (<i>m</i> = 4-6) were synthesized successfully through fragment coupling cyclization in a one-pot reaction. The introduction of pyromellitic diimide and naphthalene di... |
39899328 | Enzymatically Covalent and Noncovalent Weaving toward Highly Efficient Synthesis of 2D Monolayered Molecular Fabrics. | Molecular fabrics with fascinating physical characteristics, such as structural flexibility and single-layered thinness, have attracted much attention. Chemists worldwide have been working on building unique molecularly woven structures in two dimensions. However, the synthesis of two-dimensional molecular weaving rema... |
39899247 | Design and function of boronic acid-based polyamidoamine dendrimer probes for bacteria recognition. | Selective bacterial recognition and early diagnosis are urgently required to address the growing problem of antimicrobial resistance and are crucial for achieving sustainable development goals (SDGs). Saccharide recognition is a promising solution because bacterial surfaces are composed of specific polysaccharides. In ... |
39899201 | Evaluation of Solubility-Limited Absorption as a Surrogate to Predicting Positive Food Effect of BCS II/IV Drugs. | <h4>Introduction and objective</h4>Physiologically based pharmacokinetic (PBPK) models are increasingly used to predict food effect (FE) but model parameterization is challenged by in vitro-in vivo (IVIV) disconnect and/or parameter nonidentifiability. To overcome these issues, we propose a simplified PBPK model, in wh... |
39899056 | Socio-demographic and toxicological findings from autoptic cases in a Northern Italy community (2017-2022). | <h4>Introduction</h4>The overall trend in the use of licit and illicit substances is increasing. However, a few data on socio-demographic and toxicological findings in post-mortem cases are available.<h4>Methods</h4>A retrospective study was conducted on autoptic cases evaluated in the Institute of Legal Medicine of th... |
39898969 | Harnessing Non-standard Nucleic Acids for Highly Sensitive Icosaplex (20-Plex) Detection of Microbial Threats for Environmental Surveillance. | Environmental surveillance and clinical diagnostics heavily rely on the polymerase chain reaction (PCR) for target detection. A growing list of microbial threats warrants new PCR-based detection methods that are highly sensitive, specific, and multiplexable. Here, we introduce a PCR-based icosaplex (20-plex) assay for ... |
39898934 | Effects of water acidifiers on the growth performance, intestinal function and gut microflora in broilers. | 1. This study evaluated the effect of acidified drinking water on the gastrointestinal function and intestinal health of broilers.2. A total of 630 one-day-old male broilers (Arbor Acre) were randomly assigned to one of three treatment groups: drinking water treatment (CON), drinking water + 0.5 ml Selko pH®/L (Selko p... |
39898884 | Poly(2-alkyl-2-oxazoline) Hydrogels as Synthetic Matrices for Multicellular Spheroid and Intestinal Organoid Cultures. | The extracellular matrix (ECM) plays a crucial role in organoid cultures by supporting cell proliferation and differentiation. A key feature of the ECM is its mechanical influence on the surrounding cells, directly affecting their behavior. Matrigel, the most commonly used ECM, is limited by its animal-derived origin, ... |
39898669 | Interspecies signaling modulates the biosynthesis of antimicrobial secondary metabolites related to biological control activities of <i>Pseudomonas fluorescens</i> 2P24. | Signaling between rhizosphere microorganisms is crucial in bacteria interaction and communication, shaping the rhizomicrobiome. Plant growth-promoting bacterium <i>Pseudomonas</i> produces a spectrum of important antibiotics to inhibit plant pathogens, albeit with an associated metabolic burden. Antibiotics could funct... |
39898560 | Micellar Solvent Accessibility of Esterified Polyoxyethylene Chains as Crucial Element of Polysorbate Oxidation: A Density Functional Theory, Molecular Dynamics Simulation and Liquid Chromatography/Mass Spectrometry Investigation. | Given that the amphiphilicity of polysorbates represents a key factor in the protection of proteins from particle formation, the loss of this property through degradative processes is a significant concern. Therefore, the present study sought to identify the factors that contribute to the oxidative cleavage of the poly... |
39898501 | Biomimetic Approaches for Detecting Lead in Water Contaminated by Perovskite Solar Cells. | Perovskite-based solar cells (PSCs) have emerged as highly promising in photovoltaics. New techniques are being developed for enhancing the device's lifetime and performance. However, damaged or end-of-life lead-perovskite solar modules pose significant health and environmental risks due to the release of Pb<sup>2+</su... |
39895329 | Design and application of ferritin-based nanomedicine for targeted cancer therapy. | Owing to its unique structure and favorable biocompatibility, ferritin has been widely studied as a promising drug carrier over the past two decades. Since the identification of its inherent tumor-targeting property due to unique recognition ablity of the transferrin receptor 1 (TfR1), ferritin-based nanomedicine has a... |
39894864 | Lung-homing nanoliposomes for early intervention in NETosis and inflammation during acute lung injury. | Acute lung injury (ALI) is characterized by severe inflammation in lung tissue, excessive immune response and impaired lung function. In hospitalized high-risk patients and cases of secondary infection due to surgical contamination, it can lead to higher mortality rates and require immediate intervention. Currently, cl... |
39894843 | Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases. | As essential micronutrients, metal ions such as iron, manganese, copper, and zinc, are required for a wide range of physiological processes in the brain. However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cup... |
39892652 | Self-assembling chemodrug fiber-hydrogel for transarterial chemoembolization and radiotherapy-enhanced antitumor immunity. | Hydrogel, as a promising embolic material for hepatocellular carcinoma (HCC), may fully embolize both major vessels and peripheral microvessels. A self-assembling hydrogel composed of chemotherapeutic drugs offers significant clinical benefits without carrier introduction. Herein, we developed a sustained drug-releasin... |
39868665 | Molecular Engineering of Amino Acid Crystals with Enhanced Piezoelectric Performance for Biodegradable Sensors. | Amino acid crystals have emerged as promising piezoelectric materials for biodegradable and biocompatible sensors; however, their relatively low piezoelectric coefficients constrain practical applications. Here, we introduce a fluoro-substitution strategy to overcome this limitation and enhance the piezoelectric perfor... |
39866063 | Negative gas adsorption transitions and pressure amplification phenomena in porous frameworks. | Nanoporous solids offer a wide range of functionalities for industrial, environmental, and energy applications. However, only a limited number of porous materials are responsive, <i>i.e.</i> the nanopore dynamically alters its size and shape in response to external stimuli such as temperature, pressure, light or the pr... |
39861975 | Colorimetric Detection of Naphthalene Enabled by Intra- to Intermolecular Charge Transfer Interplay Induced by π-hole⋅⋅⋅π Interactions of a TPA-Attached Pyrazinacene. | A new Donor-Acceptor type pyrazinacene derivative (1) featuring strong ICT was synthesized by linking electron-donating triphenylamine (TPA) and electron-accepting CN groups via a pyrazinacene core. The compound exhibits a dramatic color change from greenish blue to red-violet upon selective recognition of naphthalene ... |
39853850 | High-Performance Overall Water Splitting Dominated by Direct Ligand-to-Cluster Photoexcitation in Metal-Organic Frameworks. | Expanding the spectral response of photocatalysts to facilitate overall water splitting (OWS) represents an effective approach for improving solar spectrum utilization efficiency. However, the majority of single-phase photocatalysts designed for OWS primarily respond to the ultraviolet region, which accounts for a smal... |
39853834 | Construction of Axially Chiral Dialdehydes via Rhodium-Catalyzed Enantioselective C-H Amidation. | Achieving axially chiral biaryl dialdehydes through asymmetric catalysis remains significantly challenging due to the lack of efficient strategies. In this report, we developed a rhodium-catalyzed enantioselective C-H amidation through chiral transient directing group strategy. With this new approach, a series of axial... |
39853539 | Fluorinated Macrocycle for Adsorptive Separation and Chromatographic Separation of Toluene and Methylcyclohexane. | Achieving the adsorptive separation and chromatographic separation of industrially the important chemicals toluene and methylcyclohexane using the same material is a highly desirable goal. We have successfully accomplished this using a fluorinated macrocycle tetrafluoroterphen[3]arene (4FTP3), which was synthesized and... |
39846797 | Forward- and Retro-Vapofluorochromism of Sponge-Like Macrocycle Crystals. | Achieving dynamic multicolor emission through solid-state molecular motion is of significant importance for advancing applications in organic solid-state luminescent materials. Herein, we report macrocycle crystals with unique forward- and retro-vapofluorochromic behavior, which is realized by reversible amine vapor up... |
39840702 | Photochromic Metal-Organic Frameworks Based on Host-Guest Strategy and Different Viologen Derivatives for Organic Amines Sensing and Information Anticounterfeiting. | The encapsulation of viologen derivatives in metal-organic frameworks (MOFs) to construct host-guest materials has been widely discussed owing to their distinctive spatial arrangement and physical/chemical properties. Herein, three new photochromic MOFs (NWM-1-3) have been successfully synthesized by 1,1,2,2-Tetra(4-ca... |
39833115 | Supramolecular Switching of Liquid-Liquid Phase Separation for Orchestrating Enzyme Kinetics. | Dynamic liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) and associated assembly and disassembly of biomolecular condensates play crucial roles in cellular organization and metabolic networks. These processes are often regulated by supramolecular interactions. However, the complex and d... |
39831698 | Lowering Linker Symmetry to Access Zirconium Metal-Organic Frameworks for Inverse Alkane/Alkene Separations. | Enriching the structural diversity of metal-organic frameworks (MOFs) is of great importance in developing functional porous materials with specific properties. New MOF structures can be accessed through the rational design of organic linkers with diverse geometric conformations, and their structural complexity can be ... |
39806982 | Fluorescent Artificial Receptor for Dopamine based on Molecular Recognition-driven Dynamic Covalent Chemistry in a Lipid Nanoreactor. | Molecular recognition and detection of small bioactive molecules, like neurotransmitters, remain a challenge for chemists, whereas nature found an elegant solution in the form of protein receptors. Here, we introduce a concept of a dynamic artificial receptor that synergically combines molecular recognition with dynami... |
39792379 | Rational design of redox active metal organic frameworks for mediated electron transfer of enzymes. | The efficient immobilization of redox mediators remains a major challenge in the design of mediated enzyme electrode platforms. In addition to stability, the ability of the redox-active material to mediate electron transfer from the active-site buried enzymes, such as flavin adenine dinucleotide-dependent glucose dehyd... |
39745095 | Metal-organic frameworks for the separation of xylene isomers. | Xylene isomers, including <i>para</i>-xylene (<i>p</i>X), <i>meta</i>-xylene (<i>m</i>X), <i>ortho</i>-xylene (<i>o</i>X), and ethyl benzene (EB), are important raw materials in industry. The separation of xylene isomers has been recognized as one of the "seven chemical separations to change the world". However, becaus... |
39715320 | Surface-enhanced Raman spectroscopy: a half-century historical perspective. | Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and... |
39589832 | Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival. | Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its evolutionarily conserve... |
39586031 | Store-Operated Calcium Channels in the Nervous System. | Store-operated Ca2+ entry (SOCE) is a widespread mechanism of cellular Ca2+ signaling that arises from Ca2+ influx across the plasma membrane through the Orai family of calcium channels in response to depletion of intracellular Ca2+ stores. Orai channels are a crucial Ca2+ entry mechanism in both neurons and glia and a... |
39545857 | Cu-incorporated NH<sub>2</sub>-MIL-125(Ti): a versatile visible-light-driven platform for enhanced photocatalytic H<sub>2</sub> generation and CO<sub>2</sub> photoconversion. | Here, we present for the first time an efficient platform for simultaneous H<sub>2</sub> generation and CO<sub>2</sub> conversion into HCOOH, utilizing a Cu-incorporated NH<sub>2</sub>-MIL-125(Ti) material with triethanolamine as the sacrificial agent. When subjected to light, Cu-NH<sub>2</sub>-MIL-125(Ti) exhibits a r... |
39526917 | Transformation study and characterization of Cu-BTC MOF-derived nanoporous copper oxide. | This study provides a systematic and comprehensive investigation of the transformation process of copper-based metal-organic frameworks (Cu-BTC MOFs) into nanoporous copper oxides (P-CuO<sub><i>x</i></sub>) through controlled calcination. While calcination is a well-established method for producing MOF-derived oxides, ... |
39485084 | Chemically robust functionalized covalent organic framework for the highly efficient and selective separation of bromine. | Effective sequestration of bromine holds great promise for the chemical industry's safe expansion, environmental preservation, and public health. However, attaining this goal is still challenging due to the serious drawbacks of existing adsorbents such as limited capacity, low retention efficiency, and sluggish uptake ... |
38594044 | Structural Survey of Antigen Recognition by Synthetic Human Antibodies. | Synthetic antibody libraries have been used extensively to isolate and optimize antibodies. To generate these libraries, the immunological diversity and the antibody framework(s) that supports it outside of the binding regions are carefully designed/chosen to ensure favorable functional and biophysical properties. In p... |
41743400 | Pathology and Therapeutic Significance of Fibroblast Growth Factors. | The fibroblast growth factor (FGF) family includes 22 proteins in humans. Based on their mode of action, there are three families of FGFs: paracrine FGFs (FGF 1-10, 16, 17, 18, 20, and 22), intracrine FGFs (FGF 11-14), and endocrine FGFs (FGF 19, 21, and 23). FGF signaling plays critical roles in embryonic development,... |
40354778 | Vibrational circular dichroism beyond solutions. | Since the first vibrational circular dichroism (VCD) experiments conducted in the early 1970s, VCD spectroscopy has significantly advanced and firmly established itself in various fields of modern science and technology. For example, it became one of the preferred methods for absolute configuration determination in the... |
40151822 | Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles. | Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are nanoscale lipid bilayer vesicles secreted by mesenchymal stem cells. They inherit the parent cell's attributes, facilitating tissue repair and regeneration, promoting angiogenesis, and modulating the immune response, while offering advantages like reduc... |
40006552 | Microencapsulation of Probiotics for Enhanced Stability and Health Benefits in Dairy Functional Foods: A Focus on Pasta Filata Cheese. | Probiotics provide significant health benefits, but their viability is often compromised during production, storage, and passage through the gastrointestinal tract. These challenges hinder their effective incorporation into functional applications, particularly in dairy functional foods, in which factors such as acidit... |
40006551 | Docetaxel Micelles: A New Formulation to Diminish Hypersensitivity Reactions. | <b>Background/Objectives</b>: Docetaxel is a potent anti-cancer agent capable of treating various types of cancer. However, it often induces a range of adverse reactions when used with its standard solubilizer, Tween-80, necessitating allergy prophylaxis with dexamethasone prior to administration. To mitigate the risk ... |
40005509 | Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector. | Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrP<sup>C</sup>) into the pathogenic PrP<sup>Sc</sup> isoform. Previous studies have identified nanobodies that specifically recognize PrP<sup>C</sup> and inhibi... |
40001520 | Computational Elucidation of a Monobody Targeting the Phosphatase Domain of SHP2. | Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) is a key regulator in cellular signaling pathways because its dysregulation has been implicated in various pathological conditions, including cancers and developmental disorders. Despite its importance, the molecular basis of SHP2's regulatory mechanism remain... |
39996647 | Preparation and Properties of Glycerohydrogels Based on Silicon Tetraglycerolate, Chitosan Hydrochloride and Glucomannan. | Glycerohydrogels based on silicon glycerolate, chitosan (CS) and polyvinyl alcohol (PVA) are widely studied for use in biomedical applications. In line with the general trend of replacing synthetic polymers with natural ones in such compositions, it would be of interest to replace PVA with the polysaccharide glucomanna... |
39943543 | Ultra-Sensitive Gas Sensor Based on CDs@ZnO. | Ethylene glycol (EG) is a colorless and odorless organic compound, which is an important industrial raw material but harmful to the environment and human health. Thus, it is necessary to develop high-performance sensing materials to monitor EG gas. Herein, sea urchin-shaped ZnO was successfully synthesized by a hydroth... |
39942999 | Genome Scan Analysis for Advancing Knowledge and Conservation Strategies of Primitivo Clones (<i>Vitis vinifera</i> L.). | The success of the Primitivo variety underscores the critical need for the managing of clone genetic conservation, utilization, and improvement. By combining genomic and environmental data, breeders can better predict the performance of varieties, thereby improving breeding efficiency and enabling more targeted develop... |
39942068 | Application Progress of Immobilized Enzymes in the Catalytic Synthesis of 1,3-Dioleoyl-2-palmitoyltriglyceride Structured Lipids. | In recent years, the preparation of OPO (1,3-dioleoyl-2-palmitoyltriglyceride)-structured lipids through immobilized lipase catalysis has emerged as a research hotspot in the fields of food and biomedical sciences. OPO structured lipids, renowned for their unique molecular structure and biological functions, find wide ... |
39940602 | Poly(vinyl alcohol) Nanocomposites Reinforced with CuO Nanoparticles Extracted by <i>Ocimum sanctum</i>: Evaluation of Wound-Healing Applications. | This study focused on the synthesis of plant-mediated copper-oxide nanoparticles (OsCuONPs) via the sol-gel technique and the fabrication of OsCuONP-infused PVA composite films (POsCuONPs) utilizing the solvent casting method for wound-healing applications. The prepared OsCuONPs and nanocomposite films were characteriz... |
39923691 | Effective charge of high-generation PAMAM dendrimers in the adsorbed state. | The adsorption of macromolecules onto charged surfaces is an ubiquitous process in nature and industrial processes; it has, for example, important implications for surface modification and sensors in analytics. In the case of proteins and some polyelectrolytes, such as dendritic ones, the adsorption process and the res... |
39910946 | Dendrimers as drug delivery vehicles: a comprehensive review. | Dendrimers are chemical compounds that have functional groups on their surface and a hyperbranched structure. It is simple to promote the functionality of dendrimers and produce a variety of biocompatible products by altering their terminal groups. These materials have exceptional physicochemical characteristics that m... |
39904438 | Selective production of cycloalkanes through the catalytic hydrodeoxygenation of lignin with CoNi<sub>2</sub>@BTC catalysts without external hydrogen. | Depolymerizing lignin to produce high-value chemicals under mild conditions is a significant way to achieve the sustainable development of agriculture and forestry industry, and attracting a growing number of attentions. In this work, a bimetallic Ni-Co catalyst (CoNi<sub>2</sub>@BTC) was prepared by using MOF as precu... |
39895241 | Calixarene Modification Strategy for Efficient Intracellular Protein Delivery. | Efficient intracellular protein delivery is of great importance for the development of protein-based therapy and modern biotechnologies. However, the hydrophilic and macromolecular nature of proteins greatly hinders their ability to cross cell membranes. Herein, a calixarene modification strategy for the intracellular ... |
39895194 | Rational Design of Metal-Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy. | Despite improvements in cancer survival rates, metastatic and surgery-resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses and limited treatment options. Enhancing drug bioavailability in tumors, while minimizing off-target effects, is crucial. Metal-organic frameworks (MOFs) have emerg... |
39895182 | Supramolecular Chemistry in Metal-Organic Framework Materials. | Far from being simply rigid, benign architectures, metal-organic frameworks (MOFs) exhibit diverse interactions with their interior environment. From developing crystal sponges to studying reactions in framework materials, the role of both supramolecular chemistry and framework structure is evident. We explore the role... |
39895138 | Nonaqueous G-Quadruplex Ionogels. | Supramolecular ionogels, as an emerging class of materials, utilize the intriguing properties of ionic liquids (ILs) and offer a promising method for constructing functional materials in anhydrous solvents. G-Quadruplex, assembled from guanine-rich nucleic acid building blocks, is an important structure closely associa... |
39895135 | Engineering of Polyisoprene Networks Enabled by Host-Guest Thiol-Ene Reaction. | Regulating cross-linking of polymers is critical for optimizing the physical properties of polymer networks. Herein, we present a strategic approach for designing polymer networks using dithiol-functionalized metal-organic frameworks (MOFs) with both one- and three-dimensional pore architectures. Upon thermal treatment... |
39895129 | Chiral Molecular Magnet Superstructures with Light Control. | Chiral magnets are crucial for magneto-optical coupling to advance spin-optoelectronics. Chirality breaks spatial inversion symmetry, while magnetism breaks time-reversal symmetry. However, understanding and controlling the interplay between chirality and magnetism remain fundamental challenges. Here we report chiral h... |
39895089 | Radiocopper in Radiopharmacy and Medical Use: Current Status and Perspective. | Of the 32 known copper isotopes, some have interesting properties for nuclear medicine, for example the short-lived <sup>60</sup>Cu, <sup>61</sup>Cu, <sup>62</sup>Cu, the moderate long-lived <sup>64</sup>Cu and the long-lived <sup>67</sup>Cu. Due to their emission properties, copper isotopes are suitable for both imagi... |
39895005 | Near-Perfect Purification of 2,6-Xylenol from Ternary Cresol Mixtures Using Cucurbit[7]uril. | The separation of <i>m</i>-cresol (<i>m</i>-cre), <i>p</i>-cresol (<i>p</i>-cre), and 2,6-xylenol (2,6-xyl) poses a significant challenge in industrial processes. This study focuses on selectively separating <i>m</i>-cre and <i>p</i>-cre from a ternary mixture using a cucurbit[7]uril (Q[7]) aqueous solution to achieve ... |
39895001 | Enhanced Photocatalytic Degradation of Bisphenol A by a Novel MOF/CuFe<sub>2</sub>O<sub>4</sub> Composite in Wastewater Treatment. | The synergistic effects of a CuFe₂O₄ and cobalt/nickel metal organic framework (Co/Ni-MOF) based composite (MOF/CuFe₂O₄) were explored for photodegradation of Bisphenol A (BPA), various MOF/CuFe₂O₄ composites were synthesized via a hydrothermal method, By adjusting CuFe₂O₄ to Co/Ni-MOF mass ratios of 2:1, 1:1, and 1:2 ... |
39894983 | Arginine-Rich Peptides Regulate the Pathogenic Galectin-10 Crystallization and Mitigate Crystallopathy-Associated Inflammation. | Protein self-assembly into a crystal in vivo triggers acute or chronic organ injury that can lead to intractable diseases lacking specific treatment options. In this study, we report the discovery of ionic arginine-rich peptides to disrupt the pathogenic galectin-10 (gal-10) crystallization, where the aberrant depositi... |
39894946 | Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging. | Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of the β-linked isomer l-isoaspartic acid (isoAsp) from aspartic acid (Asp) or asparagine residues, which tends to occur in long-lived proteins. Histones can exhibit half-lives o... |
39894881 | Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of V<sub>H</sub>3 and V<sub>K</sub>3 genes. | H1N1 influenza viruses are responsible for both seasonal and pandemic influenza. The continual antigenic shift and drift of these viruses highlight the urgent need for a universal influenza vaccine to elicit broadly neutralizing antibodies (bnAbs). Identification and characterization of bnAbs elicited in natural infect... |
39894863 | Environment-assisted quantum transport of excitons in perovskite nanocrystal superlattices. | Transport of energy carriers in solid-state materials is determined by their wavefunctions and interactions with the environment. While quantum transport theory has predicted distinct transport in the intermediate coupling regime resulting from the intricate interplay between coherent wave-like and incoherent particle-... |
39894818 | Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1. | Sudan ebolavirus (SUDV), like Ebola ebolavirus (EBOV), poses a significant threat to global health and security due to its high lethality. However, unlike EBOV, there are no approved vaccines or treatments for SUDV, and its structural interaction with the endosomal receptor NPC1 remains unclear. This study compares the... |
39894813 | Recycling the recyclers: strategies for the immobilisation of a PET-degrading cutinase. | Enzymatic degradation of polyethylene terephthalate (PET) represents a sustainable approach to reducing plastic waste and protecting fossil resources. The cost efficiency of enzymatic PET degradation processes could be substantially improved by reusing the enzymes. However, conventional immobilisation strategies, such ... |
39894457 | Assessment of Spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target. | <h4>Background and purpose</h4>Sphingosine-1-phosphate (S1P) receptor modulator (SRM) drugs suppress immune system function by disrupting lymphocyte trafficking, but SRMs are broadly immunosuppressive with on-target liabilities. Another strategy to modulate the immune system is to block S1P transport. This study tests ... |
39893693 | Approach to Enantiomer Recognition during Adsorption by Different Adsorption Rates on Zeotype Borophosphate LiCu<sub>2</sub>[BP<sub>2</sub>O<sub>8</sub>(OH)<sub>2</sub>] with Spontaneously Emerged Chirality. | Zeotype borophosphates are porous adsorbents with a 3D open framework. The unique feature of borophosphates is noncentrosymmetric or even chiral structures. The chirality emerged as an asymmetrical arrangement of atoms in crystals and can be referred to the supramolecular, not molecular, chirality hierarchy level. In t... |
39893663 | Cu-TCPP Metal-Organic Nanosheets Embedded Thin-Film Composite Membranes for Enhanced Cyanide Detection and Removal: A Multifunctional Approach to Water Treatment and Environmental Safety. | Cyanide is highly toxic, with widespread industrial use posing serious environmental risks. Effective materials for detecting and filtering cyanide from water are urgently needed. This study introduces a novel approach utilizing Cu-TCPP (TCPP = <i>o</i>-tetra(4-carboxyphenyl)porphine) metal-organic nanosheets (MONS) em... |
39893662 | Indirect Construction of Chiral Metal-Organic Frameworks for Enantioselective Luminescence Sensing. | ConspectusChiral metal-organic frameworks (MOFs) are promising candidates as luminescent sensing materials for chiral species, which are essential components in modern industries, pharmaceuticals, and biological processes. The discrimination of enantiomers with highly similar physical and chemical properties is crucial... |
39893661 | Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide. | Cross-link containing products from ribosomally synthesized and post-translationally modified peptides (RiPPs) are generated by radical SAM enzymes (rSAM). Here, we bioinformatically expanded rSAM enzymes based on the known families StrB, NxxcB, WgkB, RrrB, TqqB and GggB. Through <i>in vivo</i> functional studies in <i... |
41883360 | Leveraging biomimetic materials for bioelectronics. | The exploration of biomimetic materials for bioelectronics is driving transformative advancements in medical technology and beyond. Drawing inspiration from nature's intricate designs, these materials hold immense potential for creating bioelectronics that integrate seamlessly with living tissues. This work highlights ... |
41705337 | Restriction endonuclease selective inhibition by β-cyclodextrin sulfate. | Restriction endonucleases (REs) are sequence-specific DNA-cleaving enzymes that are widely used as tools in molecular biology. Although REs is not typically considered therapeutic targets, their inhibition provides a useful framework for understanding how DNA-binding enzymes can be differentially modulated. In this pre... |
41122127 | Formulation, characterization, and <i>in vitro</i> antifungal evaluation of liposomal terbinafine prepared by the ethanol injection method. | <h4>Background and purpose</h4>Fungal infections necessitate advanced delivery systems to improve antifungal therapy. Terbinafine, a potent allylamine antifungal, faces clinical limitations due to poor solubility, low bioavailability, and toxicity. Liposomal encapsulation addresses these challenges by enhancing solubil... |
40951548 | Comparative Genomic Analysis of Six Mycoplasma Gallisepticum Strains: Insights into Genetic Diversity and Antibiotic Resistance. | <i>Mycoplasma gallisepticum</i> (MG) is a significant pathogen that causes respiratory diseases, which have had a substantial economic impact on the poultry industry. Despite the resistance of MG to antibiotics, it is imperative to identify genetic diversity in order to develop countermeasures. In this study, the genom... |
40798554 | Stimuli-driven control of self-assembled radial-lying hierarchical superstructures of chiral nematics by using acoustic waves. | Supramolecular functional helical superstructures are typical structures exhibiting many fascinating properties and performances. In nature, cholesteric liquid crystals (CLCs) are self-assembled soft helical superstructures that display orientation-dependent features of supramolecular helical architectures and have pot... |
40673339 | Sumner's legacy: a century of urease crystals and recent structural advances. | In 1926, James B. Sumner crystallized jack bean urease-the first enzyme to be obtained in crystalline form-thus demonstrating that enzymes are proteinaceous. To honor the 100-year anniversary of that momentous event, this review highlights critical findings leading up to Sumner's efforts, explains the significance of h... |
40371360 | The protective effects of melatonin on testis, sperm parameters quality, and in-vitro fertilization in mice following treatment with aflatoxin B1: An experimental study. | <h4>Background</h4>Aflatoxin B1 (AFB1) contamination of foods and animal feeds is a public health issue. Exposure to AFB1 induces oxidative stress and can cause male reproductive toxicity. Melatonin (MLT) is a neuro-hormone produced by the pineal gland and the testis and is known as a potent antioxidant.<h4>Objective</... |
40166731 | Exploring superior nonlinear optical properties of copper complexes with π-conjugated ligands: experimental and theoretical investigation. | This study explores the nonlinear optical (NLO) properties of two synthesized copper complexes, {[Cu(dmp)<sub>2</sub>(H<sub>2</sub>O)]·(PA)<sub>2</sub>} (complex 1) and {[Cu(dmp)<sub>2</sub>]·(PA)} (complex 2), where dmp represents 2,9-dimethyl-1,10-phenanthroline (neocuproine) and PA refers to picric acid. Employing b... |
40144377 | The liver-brain axis under the influence of chronic Opisthorchis felineus infection combined with prolonged alcoholization in mice. | Our purpose was to model a combination of a prolonged consumption of ethanol with Opisthorchis felineus infection in mice. Four groups of C57BL/6 mice were compiled: OF, mice infected with O. felineus for 6 months; Eth, mice consuming 20 % ethanol; Eth+OF, mice subjected to both adverse factors; and CON, control mice n... |
40144376 | Studying concatenation of the Cas9-cleaved transgenes using barcodes. | In pronuclear microinjection, the Cas9 endonuclease is employed to introduce in vivo DNA double-strand breaks at the genomic target locus or within the donor vector, thereby enhancing transgene integration. The manner by which Cas9 interacts with DNA repair factors during transgene end processing and integration is a t... |
40129730 | Lipid and polyphenol removal on the structural, physico-chemical and technological properties of passion fruit epicarp flour. | The effects of defatting and dephenolization treatments on the structural, physico-chemical and technological properties of passion fruit epicarp flour (PFEF) were evaluated in this research. The FT-IR, SEM and XRD results illustrated that defatted and defree phenolics did not change the basic chemical structure of PFE... |
40115497 | Optimization ultrasonic-assisted aqueous two-phase extraction of glabridin from licorice root and its activity against the foodborne pathogen MRSA. | This study aimed to extract glabridin (GLA) from licorice using an environmentally sustainable ultrasonic-assisted aqueous two-phase extraction method and to evaluate its efficacy. The extraction parameters were optimized through single-factor experiments and response surface methodology, resulting in a GLA content of ... |
40103227 | Structural basis of TnsC oligomerization and transposase recruitment in type I-B CRISPR-associated transposons. | CRISPR-associated transposon (CAST) systems employ CRISPR-Cas systems as RNA-directed targeting modules for site-specific transposon DNA insertion. Among them, type I CASTs rely on the coordinated action of the guide RNA-bound Cascade complex and the transposon proteins TniQ, TnsC, and TnsAB. The interaction between th... |
40087884 | Transcription factor VIB-1 activates catalase-3 expression by promoting PIC assembly in Neurospora crassa. | The "p53-like" superfamily transcription factor, VIB-1, plays a crucial role in mediating heterokaryon incompatibility and regulating the transcription of specific genes involved in the secretion of extracellular hydrolases in Neurospora crassa. However, the precise mechanism underlying the transcriptional regulatory f... |
40071935 | Structural investigation of an RNA device that regulates PD-1 expression in mammalian cells. | Synthetic RNA devices are engineered to control gene expression and offer great potential in both biotechnology and clinical applications. Here, we present multidisciplinary structural and biochemical data for a tetracycline (Tc)-responsive RNA device (D43) in both ligand-free and bound states, providing a structure-dy... |
40066879 | Amyloid-like DNA bridging: a new mode of DNA shaping. | All organisms depend on specific proteins to compact and organize their genomes. In eukaryotes, histones fulfil this role, while bacterial chromosomes are shaped by nucleoid-associated proteins (NAPs). Among its pleiotropic functions, the NAP Hfq plays a pivotal role in bacterial genome organization. In this study, we ... |
40052821 | Structural basis for cooperative ssDNA binding by bacteriophage protein filament P12. | Protein-primed DNA replication is a unique mechanism, bioorthogonal to other known DNA replication modes. It relies on specialised single-stranded DNA (ssDNA)-binding proteins (SSBs) to stabilise ssDNA intermediates by unknown mechanisms. Here, we present the structural and biochemical characterisation of P12, an SSB f... |
40042813 | Decoding and reengineering the promoter specificity of T7-like RNA polymerases based on phage genome sequences. | The single subunit RNA polymerases (ssRNAPs) of bacteriophages are highly interesting targets for the prediction and engineering of specific protein-DNA interactions. Despite extensive existing studies focusing on particular ssRNAPs such as the T7 RNAP, few rules governing the protein-DNA sequence covariations across d... |
40041380 | Catalytic reduction of nitrophenols and dyes by HKUST-1/hydrogel composite. | The effective removal of nitrophenols from wastewater is crucial due to their high carcinogenic risk. This research presents the development of a copper-based metal-organic framework (HKUST-1) integrated into a chitosan-<i>graft</i>-poly(acrylic acid) hydrogel. The hydrogel composite was evaluated as a catalyst for red... |
40041381 | Supradecoration induced homogenous electrochemical sensing: development of Ru(ii) half sandwich complex as isoniazid and rifampicin dual sensor. | Homogenous electrochemical sensing using unmodified electrodes remove electrode fabrication challenges and prove effective for detecting sensitive bio-analytes without chances of surface degradation. This work envisages design and optimization of a ruthenium(ii) half-sandwich complex as supradecorated homogeneous elect... |
40041378 | Recent advances in the synthesis of anticancer pyrazole derivatives using microwave, ultrasound, and mechanochemical techniques. | Pyrazole and its derivatives have attracted considerable attention in pharmaceutical and medicinal chemistry, as reflected in their presence in numerous FDA-approved drugs and clinical candidates. This review presents a comprehensive analysis of articles published between 2014 and 2024, focusing on the microwave-, ultr... |
40041377 | Discovery of novel theophylline derivatives bearing tetrazole scaffold for the treatment of Alzheimer's disease. | Alzheimer's disease (AD) is associated with AChE and BACE1 enzymes. Designing inhibitors for preventing these enzymes can be benefit for AD treatment. In this context, theophylline derivatives were generated to prevent the biological activity of AChE and BACE1. In particular, the potential inhibitory of these compounds... |
40041372 | Smart fluorometric sensing of metal contaminants in canned foods: a carbon dot-based dual-response system for quantifying aluminum and cobalt ions. | The leaching of aluminum and cobalt ions into canned foods, such as aluminum from canned tomato sauce and cobalt from canned tuna, raises concerns about potential health risks, making their accurate detection essential for food safety. In this study, we developed a novel ratiometric fluorometric sensor based on dual-em... |
40037713 | A transcription factor from the cryptic Escherichia coli Rac prophage controls both phage and host operons. | Bacterial genomes are shaped by cryptic prophages, which are viral genomes integrated into the bacterial chromosome. Escherichia coli genomes have 10 prophages on average. Though usually inactive, prophage genes can profoundly impact host cell physiology. Among the phage genes in the E. coli chromosome, there are sever... |
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