id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
40021324 | Construction of defect-rich bimetallic MOF loaded on N, S-codoped MXene QDs/rGO for electrochemical detection of catechol. | <h4>Background</h4>Catechol (CC) is widely used in industrial synthesis but poses significant environmental and health risks due to its toxicity and low degradability. Developing sensitive and stable electrochemical sensors for CC detection is critical for effective environmental monitoring. This study presents a compo... |
40018896 | Z-scheme heterojunction BiOBr/MIL-100(Fe) visible photocatalytic-permonosulfate degradation of AO7. | Metal-organic frameworks (MOFs) have garnered significant interest in the field of photocatalysis. In this study, Z-scheme heterojunction BM-x composites consisting of bismuth bromide oxide (BiOBr) and iron-based metal-organic backbone (MIL-100(Fe)) were successfully synthesized using ethylene glycol as a solvent. The ... |
40017752 | Engineered Receptor Capture Combined with Mass Spectrometry Enables High-Throughput Detection and Quantitation of SARS-CoV-2 Spike Protein. | Mass spectrometry (MS) is a potentially powerful approach for the diagnostic detection of SARS-CoV-2 and other viruses. However, MS detection is compromised when viral antigens are present at low concentrations, especially in complex biological media. We hypothesized that viral receptors could be used for viral target ... |
40007517 | Effect of carboxymethyl cellulose and/or wheat gluten on the pasting, rheological and quality properties of wheat starch-based batter for deep-fried products. | This study aimed to investigate the effects of the individual and synergistic addition of wheat gluten (WG) and carboxymethyl cellulose (CMC) on the wheat starch (WS)-based batter characteristics to determine the molecular basis of texture formation in the actual batter system. Results showed that adding WG and/or CMC ... |
40006557 | PEGylated Nanoliposomes Encapsulated with Anticancer Drugs for Breast and Prostate Cancer Therapy: An Update. | There are different types of cancer treatments, including surgery, radiotherapy, and chemotherapy. However, the complexity of cancer has resulted in treatment challenges to medicinal scientists and a socio-economic burden to the public health system globally. The pharmacological limitations associated with the current ... |
40006558 | Exploratory Study on Nanoparticle Co-Delivery of Temozolomide and Ligustilide for Enhanced Brain Tumor Therapy. | <b>Background:</b> Temozolomide (TMZ) is the first-line therapy for glioblastoma (GBM), but its clinical efficacy is limited by its short half-life, poor brain targeting, adverse side effects, and the development of drug resistance. Ligustilide (LIG) has been shown to enhance blood-brain barrier permeability and reduce... |
40006023 | Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy. | This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was conducted in various databases for articles published in the last 10 years, with strict inclusion and exclusion criteria. Of th... |
40003790 | Sex Chromosome Dosage Compensation in Insects. | Dosage compensation (DC) is of crucial importance in balancing the sex-linked gene expression between males and females. It serves to guarantee that the proteins or other enzymatic products encoded by the sex chromosome exhibit quantitative parity between the two genders. During the evolutionary process of achieving do... |
40003636 | Genome-Wide Identification and Expression Divergence of <i>CBF</i> Family in <i>Actinidia arguta</i> and Functional Analysis of <i>AaCBF4</i> Under Cold Stress. | The C-repeat binding factors (CBFs) gene is essential for plants' cold response, which could not only be induced by the inducer of CBF expression (ICE) genes but also activated the expression of the cold-regulated (COR) gene, thereby participating in the ICE-CBF-COR cold response pathway. However, this gene family and ... |
39997672 | Insights on Hydrogen Bond Network of Water in Phospholipid Membranes: An Infrared Study at Varying Hydration. | Water in membrane interphases is vital for cellular biological functions, but despite its importance, the structure and function of biological water remain elusive. Here, by studying the OH stretching mode in partially hydrated lipid multilayers by FTIR measurements, relevant information on the water structure near the... |
39996987 | Electrochemical Technology for the Detection of Tau Proteins as a Biomarker of Alzheimer's Disease in Blood. | Alzheimer's disease (AD) is a prevalent neurodegenerative disorder and a significant cause of dementia in elderly individuals, with a growing prevalence in our aging population. Extracellular amyloid-β peptides (Aβ), intracellular tau proteins, and their phosphorylated forms have gained prominence as critical biomarker... |
39996037 | The antioxidant potential of bacoside and its derivatives in Alzheimer's disease: The molecular mechanistic paths and therapeutic prospects. | Central nervous system disorders are likely to have a substantial effect on the worldwide healthcare demands of humanity in this era. Alzheimer's disease (AD) is a senile decay of neurons. Extracellular beta-amyloid accumulation and intracellular tau hyperphosphorylation are two key characteristics of the pathogenesis ... |
39989765 | Advancements in Micro/Nanorobots in Medicine: Design, Actuation, and Transformative Application. | In light of the ongoing technological transformation, embracing advancements that foster shared benefits is essential. Nanorobots, a breakthrough within nanotechnology, have demonstrated significant potential in fields such as medicine, where diagnostic and therapeutic applications are the primary focus areas. This rev... |
39989716 | Genomic surveillance and evolution of Getah virus. | Getah virus (GETV), a member of the <i>Alphaviruses</i>, has spread widely and is expanding its host range worldwide, posing a serious threat to public health safety and the farming industry. However, genetic monitoring of GETV is inadequate, and its evolution and transmission remain unclear. This study employed revers... |
39968281 | Donor modulation brings all-in-one phototheranostics for NIR-II imaging-guided type-I photodynamic/photothermal synergistic cancer therapy. | Type-I photodynamic (PDT) and photothermal (PTT) synergistic therapy guided by fluorescence imaging in the near-infrared region II (NIR-II) is crucial for cancer diagnosis and treatment. Phototheranostics provide a promising system for efficient imaging-guided phototherapy, combining diagnostics with therapeutics withi... |
39968179 | Computational and <i>in vitro</i> evaluation of sumac-derived <sup>©</sup>Rutan compounds towards Sars-CoV-2 M<sup>pro</sup> inhibition. | The emergence of the SARS-CoV-2 virus caused the COVID-19 outbreak leading to a global pandemic. Natural substances started being screened for their antiviral activity by computational and <i>in-vitro</i> techniques. Here, we evaluated the anti-SARS-CoV-2 main protease (M<sup>pro</sup>) efficacy of <sup>©</sup>Rutan, w... |
39968011 | Emergent biotechnology applications in urology: a mini review. | Technological advances have significantly impacted the field of urology, providing innovative solutions for diagnosis, treatment, and management of various urological disorders and diseases. This article highlights four groundbreaking technologies: whole-cell biosensors, optogenetic interventions for neuromodulation, b... |
39968010 | Application and progress of 3D printed biomaterials in osteoporosis. | Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and bone formation. Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal results and are frequently associated with side effects. Recently, biomaterial-b... |
39968009 | Responsive nanomaterials in biomedicine, patent path and prospect analysis. | In recent years, responsive nanomaterials have demonstrated tremendous potential in biomedical applications due to their unique advantages in precise drug delivery and controlled release. For complex diseases such as cancer, chronic inflammation, and genetic disorders, traditional treatment methods are often limited by... |
39967996 | Immunogenetics of longevity and its association with human endogenous retrovirus K. | <h4>Introduction</h4>The human immune system is equipped to neutralize and eliminate viruses and other foreign antigens via binding of human leukocyte antigen (HLA) molecules with foreign antigen epitopes and presenting them to T cells. HLA is highly polymorphic, resulting in subtle differences in the binding groove th... |
39967793 | Overcoming beta-lactam resistance in <i>Pseudomonas aeruginosa</i> by targeting metallo-beta-lactamase VIM-1: a one-microsecond molecular dynamics simulation study. | <i>Pseudomonas aeruginosa (P. aeruginosa)</i> is a Gram-negative opportunistic pathogen with a high resistance to beta-lactam antibiotics, mainly due to the production of metallo-beta-lactamase VIM-1 (MBL-VIM-1) enzyme. This study aimed to identify new inhibitors targeting MBL-VIM-1 to restore the efficacy of beta-lact... |
39967652 | The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options. | Intracerebral hemorrhage (ICH) is a non traumatic hemorrhage that occurs in a certain part of the brain. It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, we aim to determine h... |
39943573 | A New Association Approach for Multi-Sensor Air Traffic Surveillance Data Based on Deep Neural Networks. | Air Traffic Services play a crucial role in the safety, security, and efficiency of air transportation. The International Civil Aviation Organization (ICAO) performance-based surveillance concept requires monitoring the actual performance of the surveillance systems underpinning these services. This assessment is usual... |
39943564 | Recent Progress in Intrinsically Stretchable Sensors Based on Organic Field-Effect Transistors. | Organic field-effect transistors (OFETs) are an ideal platform for intrinsically stretchable sensors due to their diverse mechanisms and unique electrical signal amplification characteristics. The remarkable advantages of intrinsically stretchable sensors lie in their molecular tunability, lightweight design, mechanica... |
39942787 | Chemical Composition of Essential Oils and Their Potential Applications in Postharvest Storage of Cereal Grains. | Insect infestation and microbial, particularly mold contamination, are the major causes of stored grain deterioration during postharvest storage, which results in a significant loss in grain quality and quantity, and the formation of toxic chemicals such as mycotoxins. Pesticides, together with physical protection stra... |
39942790 | New Perspectives of Hydrogels in Chronic Wound Management. | Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents a detailed overview of chronic wounds and emphasizes the critical need for novel therapeutic solutions. The pathophysiology of wound healing is discussed, including the healing stages and the factors contri... |
39942788 | Application of Fourier Transform Infrared (FTIR) Spectroscopy in Characterization of Green Synthesized Nanoparticles. | The fundamental principle of Fourier Transform Infrared (FTIR) spectroscopy is based on the vibration and rotation of atoms, and it has become a universal and widely used spectral methodology for the detection of internal molecular structures in a diverse range of fields. A considerable number of review articles pertai... |
39942784 | Dynamic Behavior of the Glassy and Supercooled Liquid States of Aceclofenac Assessed by Dielectric and Calorimetric Techniques. | Aceclofenac (ACF), a non-steroidal anti-inflammatory drug, was obtained in its amorphous state by cooling from melt. The glass transition was investigated using dielectric and calorimetric techniques, namely, dielectric relaxation spectroscopy (DRS), thermally stimulated depolarization currents (TSDC), and conventional... |
39941886 | Radiotherapy Plus the Neurokinin-1 Receptor Antagonist Aprepitant: A Potent Therapeutic Strategy for the Treatment of Diffuse Intrinsic Pontine Glioma. | <b>Background</b>: Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood brainstem tumor. The median survival of DIPG is 16-24 months independent of the treatment received. Therefore, new therapeutic strategies against DIPG are urgently needed. Substance P (SP) peptide, through the neurokinin neurokinin-1 ... |
39941096 | Leveraging Artificial Intelligence and Gene Expression Analysis to Identify Some Potential Bovine Coronavirus (BCoV) Receptors and Host Cell Enzymes Potentially Involved in the Viral Replication and Tissue Tropism. | Bovine coronavirus (BCoV) exhibits dual tissue tropism, infecting both the respiratory and enteric tracts of cattle. Viral entry into host cells requires a coordinated interaction between viral and host proteins. However, the specific cellular receptors and co-receptors facilitating BCoV entry remain poorly understood.... |
39941081 | Colorectal Cancer: Current and Future Therapeutic Approaches and Related Technologies Addressing Multidrug Strategies Against Multiple Level Resistance Mechanisms. | Colorectal cancer (CRC) is the third most common cancer and is associated with a poor prognosis. The mutation profile and related involved pathways of CRC have been, in broad terms, analyzed. The main current therapeutic approaches have been comprehensively reviewed here, and future possible therapeu-tic options and re... |
39940615 | Preparation and Hg<sup>0</sup> Removal Performance of MIL-101(Cr)-Derived Carbon Matrix Composites. | The temperature at which pollutants are treated varies across different industrial processes. To address the high cost of raw materials for MOFs and the low efficiency of Hg<sup>0</sup> removal in low-temperature environments, a series of MIL-101(Cr)-derived carbon matrix composite materials were prepared by combining ... |
39940610 | Polymers Derived from Agro-Industrial Waste in the Development of Bioactive Films in Food. | This review explores the potential of biopolymers as sustainable alternatives to conventional plastics in food packaging. Biopolymers derived from plant or animal sources are crucial in extending food shelf life, minimizing degradation, and protecting against oxidative and microbial agents. Their physical and chemical ... |
39940215 | Recent Advances in ZIF Membrane: Fabrication, Separation Ability and Its Application. | With the growth of the population and the development of industry and agriculture, water resources are experiencing contamination by numerous pollutants, posing a threat to the aquatic environment and human health. Zeolitic imidazolate framework (ZIF) membranes, as a solution for water pollutant treatment, not only hav... |
39938282 | Copper nanoparticles supported on metal-organic framework with topological defects for CO<sub>2</sub> hydrogenation to methanol. | The catalytic hydrogenation of CO<sub>2</sub> to methanol represents a promising strategy to reduce CO<sub>2</sub> emissions and mitigate the energy crisis. For this conversion, reoUiO-66 with topological defects was synthesized through acid etching, and a novel Cu-based catalyst (Cu@reoUiO-66) was prepared by incorpor... |
39936119 | Copper-anchored polysulfonamide-modified UiO-66-NH<sub>2</sub>/sodium alginate nanocatalyst for sustainable synthesis of 1,2,3-triazoles. | An effective nanocomposite comprising a metal-organic framework and porous polysulfonamide-sodium alginate (SA-PS) was developed for phenyl triazole production. The Cu(i) ions were uniformly distributed on the as-prepared UiO-66-NH<sub>2</sub>@SA-PS matrix, coordinated by sulfonamide groups in a bidentate bridging patt... |
39935501 | Curvature enhanced NH<sub>2</sub>-MIL-53(Al) electrode for boosting ion diffusion and capacitive deionization defluorination. | Traditional capacitive deionization (CDI) materials typically exhibit low fluorine adsorption capacity (FAC) due to limitations in the optimization of their specific surface area and chemical composition. A prospective strategy for efficient ion storage is modulating the local electric field strength (LEF) by changing ... |
39933344 | Magnetic solid phase extraction based on restricted access molecularly imprinted polymer with dually coated for enantioselective determination of tramadol in human plasma by capillary electrophoresis with ultraviolet detection. | A restricted-access magnetic molecularly imprinted polymer with dually coated of hydrophilic monomer and bovine serum albumin was synthesized, properly characterized by different techniques, and used as adsorbent in Magnetic Solid Phase Extraction (MSPE). Furthermore, a simple and efficient method employing capillary e... |
39925682 | Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies. | Given the complexity of the central nervous system (CNS) and the diversity of neurological conditions, the increasing prevalence of neurological disorders poses a significant challenge to modern medicine. These disorders, ranging from neurodegenerative diseases to psychiatric conditions, not only impact individuals but... |
39925677 | Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment. | Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in the progression of inflammatory diseases. Mitochondria, often referred to as the "power p... |
39923515 | Differential ratiometric molecularly imprinted electrochemical method for methyl-parathion and carbendazim in foods. | Non-specific adsorption of interferents on molecularly imprinted polymer (MIP) membranes bottlenecks their selective recognition to templates. Herein, we reported an improved differential MIP strategy to correct such adverse effect for determining carbendazim (CBZ) and methyl-parathion (MP) in food samples. MIP membran... |
39923397 | FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms. | Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger oxidative stress have been heavily implicated in the pathogenesis of... |
39917439 | The role of Fe incorporation into Ni-MOF-74 derived oxygen evolution electrocatalysts for anion exchange membrane water electrolysis. | The performance of Ni-based oxygen evolution reaction (OER) electrocatalysts is enhanced upon Fe incorporation into the structure during the synthesis process or electrochemical Fe uptake from the electrolyte. In light of the promising potential of metal-organic framework (MOF) electrocatalysts for water splitting, Ni-... |
39917276 | Methodological insights into intervention and outcomes in randomised controlled trials of herbal medicine for obesity: a scoping review. | <h4>Background</h4>With rising obesity rates worldwide, clinical trials focused on identifying effective treatments are increasing. While guidelines exist for pharmaceutical drugs targeting obesity, there are none for herbal medicine clinical trials for anti-obesity. Both industries refer to the same guidelines for cli... |
39914571 | β-Cyclodextrin nanosponges for the ocular delivery of therapeutic Micro-RNA in a Mouse model of retinitis Pigmentosa: A proof of concept study. | The exploitation of micro-RNA (miR) sequences as therapeutics has become highly attractive for the treatment of several diseases, including those still lacking effective cures such as retinitis pigmentosa (RP). Interestingly, miR-155-5p plays a role in photo-oxidative inflammation in wild-type mice and is up-regulated ... |
39914543 | Dual modified ferritin nanocages for tumor-targeted and microenvironment-responsive drug delivery. | Human heavy-chain ferritin (HFn) possesses a stable and uniform cage-like structure, tumor-targeting properties, self-assembly capabilities, and biocompatibility, rendering it an ideal candidate for drug delivery. Here, we developed a dual modified HFn-based nanocage (DFn) that targets the urokinase-type plasminogen ac... |
39914507 | Current landscape of metal-organic framework-mediated nucleic acid delivery and therapeutics. | Nucleic acid drugs utilize DNA or RNA molecules to modulate abnormal gene expression or protein translation in cells, enabling precise treatment for specific conditions. In recent years, nucleic acid drugs have demonstrated tremendous potential in vaccine development and treating genetic disorders. Currently, the prima... |
39909029 | Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET. | The microenvironment of membrane receptors controls their mobility, structure, interactions, and dynamics, but a systematic understanding of how it modulates receptor function is often lacking. Using single-molecule Förster resonance energy transfer (smFRET), we characterized how detergents and cholesterol modulate the... |
39905874 | Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems. | Recent advances in developing photonic technologies using various materials offer enhanced biosensing, therapeutic intervention, and non-invasive imaging in healthcare. Here, this article summarizes significant technological advancements in materials, photonic devices, and bio-interfaced systems, which demonstrate succ... |
39905873 | Superhydrophilic S-NiFe LDH by Room Temperature Synthesis for Enhanced Alkaline Water/Seawater Oxidation at Large Current Densities. | Developing high-performance oxygen evolution reaction (OER) electrocatalysts that can operate stably at large current densities in seawater plays a crucial role in enabling large-scale hydrogen production, however, it remains a significant challenge. Herein, sulfur-doped NiFe layered double hydroxide nanosheet (S-NiFe ... |
39905857 | Organotin(IV) Alkoxides, Siloxides, and Related Stannoxanes. Characterisation and Thermogravimetric Studies. | A series of C,O-chelated organotin(IV) alkoxides, L<sub>2</sub>PhSnO<sup>t</sup>Bu (4), L<sub>2</sub>PhSnOMe (6), L<sub>2</sub>Sn(O<sup>t</sup>Bu)<sub>2</sub> (11), and siloxides L<sub>2</sub>PhSnOSiPh<sub>3</sub> (3), L<sub>2</sub>Sn(OSiPh<sub>3</sub>)<sub>2</sub> (10) (L=[2-(CH<sub>2</sub>O)<sub>2</sub>CH]C<sub>6</su... |
39905796 | Structural Snapshots on Stepwise Anionic Oxoborane Formation: Access to an Acyclic BO Ketone Analogue and Its Metathesis Chemistry with CO<sub>2</sub> and CS<sub>2</sub>. | In this work, we disclose the synthesis and characterization of non-acid/base-stabilized anionic oxoboranes [<sup>Mes</sup>Ter<sub>2</sub>BO][K(L)] (<sup>Mes</sup>Ter = -C<sub>6</sub>H<sub>3</sub>-2,6-(2,4,6-Me<sub>3</sub>-C<sub>6</sub>H<sub>2</sub>)<sub>2</sub>, L = [2.2.2]-cryptand or 18-crown-6), which are isoelectr... |
39905506 | Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies. | Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription. Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as broadly applicable therapeuti... |
39905504 | Plant-microbe interactions influence plant performance via boosting beneficial root-endophytic bacteria. | <h4>Background</h4>Salvia miltiorrhiza is a highly valuable medicinal plant and its cultivation is constrained by limited suitable land. Long-term continuous cropping practices alleviate limitations in planting area as well as causes the decline in plant yield and quality. Endophytic microorganisms colonize inside plan... |
39905480 | Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems. | <h4>Background</h4>Sugar feeding is an essential aspect of mosquito biology that may be exploited for mosquito control by adding insecticides to sugar attractants, so-called 'attractive targeted sugar baits' (ATSBs). To optimize their effectiveness, ATSB products need to be maximally attractive at both short and long r... |
39905470 | Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations. | Brain tumor treatment remains a significant challenge due to their high mortality and resistance to current therapies. This paper discusses the promising potential of hydrogel-based nanoparticles as innovative drug delivery systems for brain tumor therapy. Extensive characterization techniques reveal the ability of the... |
39905428 | Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity. | The reduction of cellular PD-L1 abundance through lysosomal degradation is recognized as essential for effective and sustained targeting of PD-L1-dependent immune evasion in cancer. While Hsc70 can interact with PD-L1 to promote its lysosomal degradation, the overexpression of CMTM6 competitively inhibits this interact... |
39905186 | Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport. | Plasmodium vivax is the most widespread malaria parasite affecting humans, and its eradication is challenging due to the spread of drug-resistant parasites and their ability to remain in liver as a dormant stage. These parasites invade and multiply extensively within hepatocytes and erythrocytes in the host, relying on... |
39905100 | Repetitive stability study of remdesivir/cyclodextrin complex on the international space station. | Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an an... |
39905099 | Machine learning integrated with in vitro experiments for study of drug release from PLGA nanoparticles. | This paper investigates delivery of encapsulated drug from poly lactic-co-glycolic micro-/nano-particles. Experimental data collected from about 50 papers are analyzed by machine learning algorithms including linear regression, principal component analysis, Gaussian process regression, and artificial neural networks. T... |
39905088 | Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis. | Light chain (AL) amyloidosis is a serious systemic disease caused by the deposition of free misfolded immunoglobulin light chains (LCs) in the form of amyloid fibrils within tissues. Cardiac involvement determines prognosis and mortality. An important cytotoxic impact of amyloidogenic prefibrillar LC oligomers on cardi... |
39905050 | Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing. | Much of the therapeutic potential of mesenchymal stromal cells (MSCs) is underpinned by their secretome which varies significantly with source, donor and microenvironmental cues. Understanding these differences is essential to define the mechanisms of MSC-based tissue repair and optimise cell therapies. This study anal... |
39905025 | Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model. | Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Remarkably, when coupled with cap... |
39904989 | Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation. | Viscoelastic heterogeneity of matrices plays a pivotal role in cancer cell spreading, migration, and metastasis. However, the creation of viscoelastic platforms with spatial-temporal regulation is hindered by cytotoxicity and short regulation durations. Our research presents a dual mechanism for stress relaxation regul... |
39904983 | Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study. | Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. Despite extensive research on Hp glycosylation as a glyco-biomarker for cancers, understanding glycosylated modifications of Hp in sepsis patients (SPs) remains limited.... |
39904974 | Discrete coordination nanochains based on photoluminescent dyes reveal intrachain exciton migration dynamics. | Elucidating exciton migration in polymer chains has been one of the major research goals in photophysics for over half a century. While great efforts have been made to understand picosecond phenomena by ultrafast spectroscopy, ambiguous molecular conformations and/or random polymer sequences have hindered the construct... |
39904888 | Biomimetic separations in chemistry and life sciences. | Since Otto Schmitt introduced the term "biomimetics" in 1957, the imitation of biological systems to develop separation methods and simulate biological processes has seen continuous growth, particularly over the past five decades. The biomimetic approach relies on the use of specific ligands-biospecific, biomimetic, or... |
39904836 | Yin Yang 1: Function, Mechanisms, and Glia. | Yin Yang 1 is a ubiquitously expressed transcription factor that has been extensively studied given its particular dual transcriptional regulation. Yin Yang 1 is involved in various cellular processes like cell cycle progression, cell differentiation, DNA repair, cell survival and apoptosis among others. Its malfunctio... |
39904809 | Sex Pheromone of the Papaya Mealybug. | Sex pheromones of mealybugs are reported from more than 20 species and have generally been shown to be monoterpene alcohols esterified with short-chain carboxylic acids. Here, however, we discovered and isolated an alcohol without an acid moiety as a pheromone compound released from adult females of the papaya mealybug... |
39904797 | PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF-κB p50-deficient immature myeloid cells (p50-IMC) and phagocytosis by their macrophage progeny. | Adoptive transfer of immature myeloid cells lacking the repressive NF-κB p50 subunit (p50-IMC) slows the growth of syngeneic murine prostate cancer and other tumors. Directing p50-IMC to tumors using Fc receptor-bound antibodies (Abs) or surface chimeric antigen receptors (CARs) may increase tumor localization and subs... |
39904739 | Photophysical Properties of Tandem Quantum Defects in Carbon Nanotubes. | Single-walled carbon nanotubes (SWCNTs) are versatile near-infrared (NIR) fluorophores that can be chemically functionalized to create biosensors. Numerous noncovalent approaches were developed to detect analytes, but these design concepts can be susceptible to nonspecific binding and reduced stability. In contrast, co... |
39904729 | Light-Tuning Surface Activity and Emulsion Stability of Macromolecular Surfactants Based on the Host-Guest Interaction. | Supramolecular chemistry provides more possibilities to design responsive macromolecular surfactants. In this study, poly(<i>N</i>-isopropylacrylamide) (Pnipam) with (azobenzene) AZO as the end group (Pnipam-AZO) was synthesized (P1 and P2), and then an inclusion complex was formed by Pnipam-AZO and β-cyclodextrin-modi... |
39904516 | Linear Dichroism Microscopy Resolves Competing Structural Models of a Synthetic Light-Harvesting Complex. | The initial stages of photosynthesis in light-harvesting antennae, driven by excitonic energy transport, have inspired the design of artificial light-harvesting complexes. Double-walled nanotubes (DWNTs) formed from the cyanine dye C8S3 provide a robust, self-assembled system that mimics natural chlorosomes in both str... |
39903821 | Structural Colors Go Active. | Structural colors find wide applications for color printing, intelligent display, filtering imaging, etc., owing to their benefits, including high resolution, stable properties, and dynamic tunability. This review first illustrates the mechanisms of structural color generation, such as surface plasmon resonances, local... |
39903797 | Electrochemical Hydrogen Evolution with Metal-Organic Framework-Derived Catalysts: Strategies for d-Band Modulation by Electronic Structure Modification. | The effective use of metal-organic framework (MOF)-based materials in the electrocatalytic hydrogen evolution reaction (HER) relies on the understanding of their structural and electronic properties. While the structure and morphology of MOF-derived catalysts significantly impact HER activity, tuning the d-band structu... |
39903789 | Enterovirus-like particles encapsidate RNA and exhibit decreased stability due to lack of maturation. | To counteract hand, foot, and mouth disease-causing viruses such as enterovirus A71 and coxsackievirus A6, virus-like particles (VLPs) have emerged as a leading contender for the development of a multivalent vaccine. However, VLPs have shown rapid conversion from a highly immunogenic state to a less immunogenic state a... |
39903758 | RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol-Triggered MET Activation. | Metastasis remains a significant challenge in the treatment of hepatocellular carcinoma (HCC). The role of ribonuclease T2 (RNASET2) in HCC is still uncertain, although it has been reported to have contradictory effects on some cancers. Here, it is demonstrated that RNASET2 knockout leads to significant accumulation of... |
39903700 | Graph-Property Relationships for Complex Chiral Nanodendrimers. | Organic, polymeric, and inorganic nanomaterials with radially diverging dendritic segments are known for their optical, physical, chemical, and biological properties inaccessible for traditional spheroidal particles. However, a methodology to quantitatively link their complex architecture to measurable properties is di... |
39903110 | Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles. | Cytotoxic attack particles released by CTLs and NK cells include diverse phospholipid membrane and glycoprotein encapsulated entities that contribute to target cell killing. Supramolecular attack particles (SMAPs) are one type of particle characterized by a cytotoxic core enriched in granzymes and perforin surrounded b... |
39903060 | PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies. | Circumsporozite protein (CSP), the most abundant surface protein in parasitic <i>Plasmodium falciparum</i> (Pf) sporozoite and an attractive target for malaria vaccine design, has been shown to induce protective humoral response in humans. In this work, we characterized and formulated a promising recombinant PfCSP immu... |
39902947 | Targeting <i>Mycobacterium tuberculosis</i> Parallel G-Quadruplex Motifs with Aminoglycosides Neomycin and Streptomycin: Spectroscopic and Calorimetric Aspects. | <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) contains potential G-quadruplex (PGQ) motifs in the genes <i>espK</i> and <i>cyp51</i>, which are crucial for the bacteria's virulence within host cells. Aminoglycoside molecules are commonly used as antibiotics for ribosomal targets. This study provides insight into the i... |
39902935 | An alternative splicing caused by a natural variation in BnaC02.VTE4 gene affects vitamin E and glucosinolate content in rapeseed (Brassica napus L.). | Vitamin E (VE) is essential for plants and animals. Rapeseed oil is rich in α-tocopherol (α-T), which is the most bioactive form of VE in human body. This study demonstrated that VE in rapeseed seeds was mainly controlled by embryo genotype through incomplete diallel hybridization. By genome-wide association study, the... |
39902810 | Microenvironment Matters: Copper-Carbon Composites Enable a Highly Efficient Carbon Dioxide Reduction Reaction to C<sub>2</sub> Products. | Copper is the catalyst widely used to produce multicarbon products for the carbon dioxide reduction reaction (CO<sub>2</sub>RR). The surrounding microenvironment of copper plays a crucial role in determining its catalytic activity and selectivity. In this study, we compare three copper electrocatalysts with different m... |
39902783 | Alkoxylation and Phosphorylation of Pyrimidine Disulfides: Green Synthesis of Alkoxypyrimidine Thioethers and Pyrimidine Phosphorothioates. | This paper addresses a novel, green, and sustainable method to construct new C-S and P-S bonds by cleaving the S-S bond in pyrimidine disulfide under various conditions. The first alkoxylation and phosphorylation of pyrimidine disulfide are effectively accomplished by this approach. Compared to the methods reported, th... |
39902613 | Machine Learning-Guided Selection of Cyclodextrins for Enhanced Biosynthesis and Capture of Volatile Terpenes. | Nootkatone and limonene are valuable volatile organic compounds (VOCs), but their biosynthetic production is hindered by volatility. This study employed machine learning to guide cyclodextrin (CD) selection for encapsulating these VOCs, with a focus on nootkatone capture during fermentation to prevent losses and potent... |
39902607 | Water Transport Dynamics and Kinetic Equilibria in Nanoblisters at the Graphene-Mica Interface. | Nanoscale reduced volumes with novel properties can be produced from 2D materials like graphene. Mild thermal annealing imposes vast and varied amounts of water intercalation into the graphene-mica interface, resulting in the formation of nanoblisters and impacting the local environment for applications such as reactio... |
39902602 | Central Interaction of 2-Methoxyestradiol and Lipoxygenase in AngII-Hypertension. | <h4>Background</h4>Our previous findings that arachidonic acid-12/15-lipoxygenase (LOX)-generated metabolite 12(S)-HETE contributes to angiotensin II (AngII)-induced hypertension and 17β-estradiol protects from AngII-induced hypertension via its cytochrome P450 (CYP)1B1-generated metabolite 2-methoxyestradiol in the pa... |
39901230 | Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken. | <h4>Background</h4>Crossbreeding is widely promoted as an efficient strategy to improve the productivity in agriculture. The molecular mechanism underlying heterosis for egg production is always intriguing in chicken. The transcriptional dynamic changes play a crucial role in the formation of heterosis, but little is k... |
39901180 | Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD. | <h4>Background</h4>Cellular senescence, a hallmark of aging, has been implicated in Alzheimer's disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in c... |
39900898 | Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy. | Cancer remains a major health challenge, with the effectiveness of chemotherapy often limited by its lack of specificity and systemic toxicity. Nanotechnology, particularly in targeted drug delivery, has emerged as a key innovation to address these limitations. This study introduces lipoic acid-boronophenylalanine (LA-... |
39900573 | Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism. | Treatment of solid tumors remains challenging and therapeutic strategies require continuous development. Tumor-infiltrating macrophages play a pivotal role in tumor dynamics. Here, we present a Macrophage-Drug Conjugate (MDC) platform technology that enables loading macrophages with ferritin-drug complexes. We first sh... |
39865356 | Drug-Assisted White Light Generation Via Self-Assembly. | White-light (WL) generation using small organic molecules has gained significant attention from researchers working on the interface of supramolecular chemistry and organic materials. Self-assembled multi-chromophoric materials utilizing a drug molecule and microenvironment-sensitive intramolecular charge transfer dye ... |
39831789 | The fluoroquinolone compounds potentiate the antifungal activity of the echinocandins against Aspergillus fumigatus. | The antifungal drugs of the echinocandin family show high efficacy against Aspergillus fumigatus. However, their paradoxical effect, which restores fungal growth at high drug concentrations, and the emergence of resistant strains necessitate improvements. We identified 13 fluoroquinolone compounds from a chemical libra... |
39812449 | A photoswitchable [2]catenane receptor. | A [2]catenane-based receptor functionalized with stiff-stilbene can be reversibly switched with 340/385 nm light between its <i>Z</i>- and <i>E</i>-isomers, which leads to a considerable change in chloride binding affinity. Photoisomerization in the presence of chloride allows for <i>in situ</i> on demand guest uptake ... |
39812348 | MOF confinement enables selective synthesis of novel oxazoles from indole and formaldehyde. | Herein, we report the successful guidance of indole and formaldehyde reactivity by precisely tuning the pore size and active sites of MOF, altering their intrinsic reaction pathways. This led to the first example of novel compounds synthesized through the synergistic catalysis enabled by MOF confinement. Detailed mecha... |
39810646 | <i>In situ</i> formed CuSn alloy from multivariate metal-organic frameworks for tunable CO<sub>2</sub> electroreduction. | A molecular ligand separation method based on multivariate metal-organic frameworks (MOF) is developed to precisely regulate CuSn alloy for tuning the selectivity of HCOOH and CO in CO<sub>2</sub> reduction. With this method, the agglomeration and heterogeneous nucleations of metals are effectively inhibited during the... |
39810586 | Inducing piezoelectric behavior in a copper iodide cubane cluster-based metal-organic framework <i>via</i> linker engineering. | Cu<sub>4</sub>I<sub>4</sub> cubane-type secondary building units are reticulated with a piperazine linker at room temperature to crystallize the metal-organic frameworks (MOFs) Cu<sub>4</sub>I<sub>4</sub>(Pip)<sub>2</sub> in a non-centrosymmetric <i>P</i>6<sub>2</sub>22 space group. For the first time, cubane cluster t... |
39789890 | Recent developments in pillar[5]arene-based nanomaterials for cancer therapy. | Nanomaterials possess unique size characteristics, enabling them to cross tissue gaps, penetrate the blood-brain barrier and endothelial cells, and release drugs at the cellular level. Additionally, the surface of nanomaterials is readily functionalized, endowing them with good biocompatibility, low biotoxicity, and sp... |
39785997 | Mo(0) carbonyl complexes bearing the bis(3,5-dimethylpyrazole) ligand: catalysis of the regioselective [2 + 2 + 2] cycloaddition of terminal alkynes to synthesize 1,3,5-isomers. | The reaction between 1,3-bis(3,5-dimethylpyrazolylmethyl)hexahydropyrimidine L and Mo(CO)<sub>6</sub> in CH<sub>3</sub>CN at 130 °C afforded a binuclear Mo(0) complex 1 containing a new macrocycle formed upon C-N bond cleavage in L in good yield. Conversely, a clean reaction takes place between L and [Mo(CO)<sub>4</sub... |
39785990 | Tröger's base-embedded macrocycles with chirality. | The birth and development of supramolecular chemistry have heralded a new era, where macrocycles have become an irreplaceable research tool. Therefore, the construction of novel macrocycles has become a hot spot. Tröger's base (TB), as a fragment with both rigidity and chirality, promises tremendous potential in the re... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.