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40036503 | Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase. | The average eukaryotic transfer ribonucleic acid (tRNA) contains 13 post-transcriptional modifications; however, their functional impact is largely unknown. Our understanding of the complex tRNA aminoacylation machinery in metazoans also remains limited. Herein, using a series of high-resolution cryo-electron microscop... |
40035016 | Dual-functional co-crystal of streptavidin and ssDNA: electrostatic assembly with positively charged peptide tags. | We have achieved a novel co-crystal in which the dual functions of the protein and single-stranded DNA are maintained by introducing a charged peptide tag at the C-terminus of the protein. The functionalities allowed the co-crystals to be modified with high selectivity. Additionally, we have confirmed that energy trans... |
40035015 | On the impact of aromatic core fluorination in hydrogen-bonded liquid crystals. | Herein we report the impact of fluorine substitution on the liquid crystalline (LC) self-assembly of supramolecular hydrogen-bonded rod-like architectures. This was systematically investigated by introducing fluorine atom at different positions or with different numbers on the investigated supramolecules. Therefore, ei... |
40035013 | Scrutinization of late first-row transition metals decorated octagonal boron (B8) ring complexes as single-atom catalysts for green hydrogen and oxygen production. | Hydrogen as fuel has gained large interest nowadays as a green energy source. Single-atom catalysis has emerged as a promising strategy for producing hydrogen. Herein, we investigated the late first row transition metals (TM = Co, Cu, Zn, Ni and Fe) adsorbed on eight-membered boron ring (TM@B8) as potential single-atom... |
40035008 | A hybrid scaffold of modified human amniotic membrane with gelatine/dendrimer-protected silver nanoparticles for skin wound healing applications. | The human amniotic membrane (hAM) is a biological material widely utilized to mimic the extracellular matrix in damaged skin. Despite its potential, clinical applications of hAM have been hindered by its poor mechanical properties. Furthermore, cryopreservation process used to store hAM could compromise its inherent ba... |
40035009 | Cellulose aerogel-based copper oxide/carbon composite for supercapacitor electrode. | Carbon composite is one of the most competitive electrode materials for supercapacitor, and improving its energy density remains a significant challenge. The copper oxide/carbon composites with high specific surface area were prepared from the cellulose aerogel loaded with copper salts. The copper oxide/carbon composit... |
40035006 | Metal oxides and their composites for the remediation of organic pesticides: advanced photocatalytic and adsorptive solutions. | Metal oxide nanoparticles and their composites have garnered significant attention in water treatment and environmental cleanup due to their unique physicochemical properties. These materials exhibit distinct crystalline structures, tunable morphologies, large surface areas, versatile surface chemistry, and widespread ... |
40026628 | Chitin nanocrystal-reinforced chitin/collagen composite hydrogels for annulus fibrosus repair after discectomy. | Discectomy is a widely utilized approach for alleviating disc herniation; however, effective repair of postoperative annulus fibrosus (AF) defects remains a significant challenge. This study introduces a hydrogel patch with enhanced mechanical properties for AF repair fabricated using chitin (Ch), collagen (Col), and c... |
40026624 | Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment. | The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack of intrinsic bioactivities to orchestrate the intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed of silk methacrylate and snail mucus... |
40015767 | An electrochemical biosensor for the detection of BRCA1 based on MOF-derived CeO<sub>2</sub>@CuS nanosheets with high electrocatalytic H<sub>2</sub>O<sub>2</sub> reduction performance. | <h4>Background</h4>Since the incidence of breast cancer ranks first among female malignant tumors, early diagnosis and treatment of breast cancer are crucial to women's health. Therefore, the detection and monitoring of breast cancer susceptibility gene (BRCA1) is particularly important. In this paper, an electrochemic... |
40009371 | Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells. | <h4>Purpose</h4>Cross-linked actin networks (CLANs) are prevalent in the glaucomatous trabecular meshwork (TM). We previously developed the GTM3L cell line, which spontaneously forms fluorescently labeled CLANs, by transducing GTM3, a transformed glaucomatous TM cell line, with a lentivirus expressing the LifeAct-GFP f... |
40006549 | Development, Characterization, and Antimicrobial Evaluation of Hybrid Nanoparticles (HNPs) Based on Phospholipids, Cholesterol, Colistin, and Chitosan Against Multidrug-Resistant Gram-Negative Bacteria. | <b>Background:</b> Colistin, a lipopeptide antibiotic usually used as a last resort against multidrug-resistant bacterial strains, has also begun to address the challenge of antimicrobial resistance. <b>Objective</b>: this study evaluates whether hybrid nanoparticles (HNPs) composed of Phospholipon<sup>®</sup> 90G, cho... |
40005680 | Production and Bioseparation Applications of Polyhydroxyalkanoate Nano-Granules Functionalized with Streptavidin. | Rapidly growing industrial biotechnology and bio-manufacturing require simple and cost-effective bioseparation tools. A novel strategy of bioseparation based on the streptavidin-decorated polyhydroxyalkanoate (PHA) nano-granules was developed in this study. By fusing to the N-terminus of PHA-associated phasin protein, ... |
40001506 | 60 Years of Studies into the Initiation of Chromosome Replication in Bacteria. | The <i>Replicon Theory</i> has guided the way experiments into DNA replication have been designed and interpreted for 60 years. As part of the related, explanatory package guiding experiments, it is thought that the timing of the cell cycle depends in some way on a critical mass for initiation, <i>Mi</i>, as licensed b... |
39999635 | Theoretical study on acridine-thioxanthene bridged TADF molecules presenting TSCT and TBCT features and the design for full-color emission. | We have theoretically studied a series of acridine-thioxanthene bridged thermally activated delayed fluorescence (TADF) molecules, 2PhCzSpiroS, 2PhCzSpiroS-2, SpiroS-2TRZ, TPA-SpiroS-TRZ, BOP-SpiroS-TRZ and QX-SpiroS-TRZ by using DFT/TD-DFT methods, and screened out a series of potential full-color TADF materials. Firs... |
39998169 | Perturbative spin-orbit couplings for the simulation of extended framework materials. | A comprehensive description of photo-chemical processes in materials, comprising spin-forbidden processes such as intersystem crossing and phosphorescence, implies taking into account spin-orbit coupling. We present an efficient implementation of a perturbative spin-orbit coupling correction for the Tamm-Dancoff approx... |
39998163 | Accelerated linear algebra for large scale DFT calculations of materials on CPU/GPU architectures with CRYSTAL. | We discuss the implementation strategy, numerical accuracy, and computational performance of the acceleration of linear algebra operations through graphics processing units (GPUs) for the self-consistent field driver of the Crystal electronic structure package for solid state density functional theory simulations. Acce... |
39997110 | Supramolecular Adhesives Inspired by Nature: Concept and Applications. | Supramolecular chemistry, a relatively newly grown field, has emerged as a useful tool to fabricate novel smart materials with multiple uses. Adhesives find numerous uses, from heavy engineering to biomedical science. Adhesives are available in nature; inspired by them and their mechanism of adhesion, several supramole... |
39996815 | Metabolomics and Transcriptomics Jointly Explore the Mechanism of Pod Color Variation in Purple Pod Pea. | Although the pod color was one of the seven characteristics Mendel studied in peas, the mechanism of color variation in peas with purple pods has not been reported. This study systemically analyzed the difference between two pea accessions with green pods (GPs) and purple pods (PPs) at two pod developmental stages from... |
39995104 | Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy. | Glioblastoma (GBM) carries a dismal prognosis, with a median survival of less than 15 months. Temozolomide (TMZ), the standard frontline chemotherapeutic for GBM, is an alkylating agent that generates DNA O<sup>6</sup>-methylguanine (O<sup>6</sup>MeG) lesions. Without O<sup>6</sup>MeG-methyltransferase (MGMT), this les... |
39995038 | Regulation of CRISPR trans-cleavage activity by an overhanging activator. | The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a system exhibits extraordinary capability in the field of molecular diagnosis and biosensing, attributed to its trans-cleavage ability. The precise modulation of performance has emerged as a significant challenge in advancing CRISPR technology... |
39993956 | Mitsugumin 53 Inhibits Angiogenesis Through Regulating Focal Adhesion Turnover and Tip Cell Formation. | Our previous studies have identified mitsugumin 53 (MG53) as a novel regulator for angiogenesis by directly entering endothelial cells and modulating focal adhesion kinase (FAK) activation, but little is known about how rhMG53 is taken up by cells and how rhMG53 mediates cell movement. In the present study, we demonstr... |
39991674 | Modified <i>Pulsatilla</i> decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota. | <h4>Background</h4>Modified <i>Pulsatilla</i> decoction (PD), a PD with licorice and ejiao, is a classic Traditional Chinese Medicine formula with significant efficacy in treating intestinal mucositis (IM) induced by tumor therapy. However, its specific molecular and biological mechanisms remain unclear.<h4>Aim</h4>To ... |
39989259 | VSTM1/SIRL-1: An Inhibitory Pattern Recognition Receptor Regulating Myeloid Cells. | Innate immune cells express a plethora of inhibitory receptors, many of which recognize molecular patterns. An appropriate balance between signaling via activating and inhibitory pattern recognition receptors is important for a proper immune response while preventing immunopathology. V-set and transmembrane domain cont... |
39989021 | KAT8 facilitates the proliferation of cancer cells through enhancing E7 function in HPV-associated cervical cancer. | Persistent human papillomavirus (HPV) infection serves as the principal etiological factor in cervical cancer, with the oncoprotein E7, which is encoded by the virus, playing a key role in tumorigenesis. However, targeted therapeutic strategies against E7 remain underexplored. KAT8, a lysine acetyltransferase, signific... |
39988644 | Identification of small fiber neuropathy in neuronal intranuclear inclusion disease: A clinicopathological study. | <h4>Introduction</h4>Neuronal intranuclear inclusion disease (NIID) manifests as dementia combined with other neurological symptoms. However, small fiber neuropathy (SFN) and pathology remain unknown in NIID.<h4>Methods</h4>A total of 294 subjects, including patients with NIID, Parkinson's disease, Alzheimer's disease,... |
39983165 | Statistical Mechanics Approach to DNA-Driven Droplet Deformation and Adhesion. | Adhesion of soft particles with mobile linkers is of importance in colloidal self-assembly, the binding of vesicles, and tissue organization in biology. Here we derive and experimentally test an equilibrium theory that captures the adhesion of DNA-coated emulsion droplets. Notably, we identify a transition from spheric... |
39973572 | Recent Advances in Bioanalysis of Cephalosporins Toward Green Sample Preparation. | This review highlights recent advances in the bioanalysis of cephalosporins using liquid chromatographic methods, focusing on green sample preparation (GSP) techniques. Cephalosporins, a class of β-lactam antibiotics, are critical in combating bacterial infections but present challenges related to drug resistance and t... |
39970873 | KRAS<sup>G12D</sup>-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC. | The KRAS<sup>G12D</sup> inhibitor MRTX1133 shows the potential to revolutionize the treatment paradigm for pancreatic ductal adenocarcinoma (PDAC), yet presents challenges. Our findings indicate that KRAS<sup>G12D</sup> remodels a pentose phosphate pathway (PPP)-dominant central carbon metabolism pattern, facilitating ... |
39968706 | 30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea. | <h4>Background</h4>Rosacea is a chronic skin condition that affects millions of people worldwide, and its management continues to pose a significant challenge in dermatology.<h4>Aim</h4>In this study, we investigated the efficacy and safety of 30% supramolecular salicylic acid (SSA) as a treatment for papulopustular ro... |
39967027 | MdVQ37 Negatively Regulates Apple Resistance to Valsa Canker via SA-Dependent and SA-Independent Pathways. | Apple Valsa canker is one of the major fungal diseases adversely affecting the apple industry. Valine-glutamine motif-containing proteins (VQs) are a kind of plant transcription regulation cofactor, which are involved in regulating the growth and development of plants and their defence responses. Yet little is known ab... |
39964147 | Significance of Gelsolin Superfamily Genes in Diagnosis, Prognosis and Immune Microenvironment Regulation for Endometrial Cancer. | <h4>Background</h4>Previously, anti-CTLA4 and anti-PD-1/PD-L1 immunotherapies have shown limited efficacy in MSI-H/MMR-D endometrial cancer, leading to poor clinical outcomes. The gelsolin superfamily, which includes GSN, SCIN, VILL, VIL1, CAPG, AVIL, SVIL, and FLII, plays crucial roles in cell motility and gene regula... |
39961802 | The current research status of immobilized lipase performance and its potential for application in food are developing toward green and healthy direction: A review. | Immobilized lipases have received great attention in food, environment, medicine, and other fields due to their easy separation, high stability (temperature, pH), and high storage properties. After immobilization, lipase transforms from a homogeneous to a heterogeneous state, making it easier to recover from the reacti... |
39960964 | Advancements in nanoparticles-based therapeutic approaches for osteosarcoma: Insights from catechins-modified selenium-doped hydroxyapatite: A review. | Osteosarcoma is common in all age groups, and a multifaceted strategy that includes radiation therapy, surgical intervention and chemotherapy remains the conventional treatment for osteosarcoma. Existing therapies typically result in recurring malignancies and postsurgical bone abnormalities, necessitating novel strate... |
39959279 | Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress. | <h4>Background</h4>Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities. The effects mediated by the silent information regulator type 2 homolog-1 (SIRT1)/peroxisome proliferator-activated receptor-gamma... |
39958558 | Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome: From action mechanism to therapeutic target in clinical trials. | The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a critical modulator in inflammatory disease. Activation and mutation of NLRP3 can cause severe inflammation in diseases such as chronic infantile neurologic cutaneous and articular syndrome, Muckle-Wells s... |
39958554 | Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma. | <h4>Background</h4>Hepatocellular carcinoma (HCC) ranks as the fourth leading cause of cancer-related deaths in China, and the treatment options are limited. The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) activates the stimulator of interferon gene (STING) signaling pathway as a crucial immu... |
39958488 | Future Perspectives on the Automation and Biocompatibility of Molecularly Imprinted Polymers for Healthcare Applications. | Molecular recognition is of crucial importance in several healthcare applications, such as sensing, drug delivery, and therapeutics. Molecularly imprinted polymers (MIPs) present an interesting alternative to biological receptors (e.g., antibodies, enzymes) for this purpose since synthetic receptors overcome the limite... |
39957160 | Effect and mechanism of Sanqi () in treating periodontitis. | <h4>Objective</h4>To investigate the effect and mechanism of Sanqi (<i>Radix Notoginseng</i>) in treating periodontitis.<h4>Methods</h4>The active components and periodontitis targets were analyzed through network pharmacology and molecular docking. A rat model of periodontitis was established and rats were treated by ... |
39948642 | The Supramolecular Architecture of Mitochondrial Complex I in the Rat Brain Is Altered by Alzheimer's-Like Cerebral Amyloidosis. | Mitochondrial respiratory complexes are organized into supercomplexes (SC) to regulate electron flow and mitigate oxidative stress. Alterations in SC organization in the brain may affect energy expenditure, oxidative stress, and neuronal survival. In this report, we investigated the amount, activity and organization of... |
39946269 | Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin. | <h4>Objective</h4>To develop a stable and efficient delivery system for baicalin, a flavonoid with potential antioxidant and antiaging properties, to overcome its limitations in solubility, stability, and skin permeability.<h4>Methods</h4>Baicalin was encapsulated using ATP synthase molecular motor technology into bio-... |
39945524 | Evaluation of Density-Functional Tight-Binding Methods for Simulation of Protic Molecular Ion Pairs. | In this work, we benchmark the accuracy of the density-functional tight-binding (DFTB) method, namely the long-range corrected second-order (LC-DFTB2) and third-order (DFTB3) models, for predicting energetics of imidazolium-based ionic liquid (IL) ion pairs. We compare the DFTB models against popular density functional... |
39945442 | Mechanistic Study of the Carbonylation of Aziridines to β-Lactams: Alkylation, Solvent and Molecular NaBr and MgO Clusters Catalysts Effects. | Using first principles methodology, we show that molecular NaBr and MgO nanoclusters are efficient ecofriendly and transition metal free catalysts for the carbonylation of aziridines to β-lactams. Multi-step mechanisms are proposed, where the activation energies of the rate-determining step are strongly lowered compare... |
39945371 | Water intrusion in hydrophobic MOFs with complex topology: A glimpse of the intrusion mechanism of Cu2(tebpz). | Despite water intrusion in microporous materials being extensively investigated, obtaining a detailed overview of the intrusion mechanism in materials with more complex morphology, topology, and physical-chemical characteristics, such as metal-organic frameworks (MOFs), is far from trivial. In this work, we present a q... |
39945297 | Granulosa cell expression of Fos is critical for regulating ovulatory gene expressions in the mouse ovary. | A previous study showed that female Fos null mice fail to ovulate even when given gonadotropins, suggesting that ovarian expression of Fos is critical for successful ovulation. However, the expression of FOS and function of FOS have not been determined in the mouse ovary. FOS, a member of the Fos family (Fos, Fosb, Fos... |
39945049 | A Novel Method to Calibrate Spring-Network Cell Model in Hydrodynamic Flow. | One of the primary challenges encountered during the extrusion bioprinting process involves managing mechanical stresses within the printer nozzle. These stresses ultimately have an impact on the health and functionality of the cells within the printed structure. Statistical models in bioprinting predict cell damage bu... |
39942990 | Silver Nanoparticles Help Plants Grow, Alleviate Stresses, and Fight Against Pathogens. | The use of silver nanoparticles (AgNPs) has gained importance in agriculture in recent years thanks to their unique characteristics, including their antimicrobial capacity and their ability to promote plant growth. Due to these attributes, AgNPs are considered a promising solution for the future of agriculture, offerin... |
39942759 | Carboxyethylsilanetriol-Functionalized Al-MIL-53-Supported Palladium Catalyst for Enhancing Suzuki-Miyaura Cross-Coupling Reaction. | The application of metal-organic frameworks (MOFs) has attracted increasing attention in organic synthesis. The modification of MOFs can efficiently tailor the structure and improve the property for meeting ongoing demand in various applications, such as the alteration of gas adsorption and separation, catalytic activi... |
39942754 | Machine Learning Descriptors for CO<sub>2</sub> Capture Materials. | The influence of machine learning (ML) on scientific domains continues to grow, and the number of publications at the intersection of ML, CO<sub>2</sub> capture, and material science is growing rapidly. Approaches for building ML models vary in both objectives and the methods through which materials are represented (i.... |
39942750 | An Environmental Engineering Study Case: Constructing Cataluminescence Sensors Based on Octahedral Nanocomposites for Isovaleraldehyde Detection. | Isovaleraldehyde is an important chemical raw material for the production of flavors, which is volatile and flammable and poses a health risk to humans. It is, therefore, essential to develop a rapid assay for the identification of isovaleraldehyde. In this study, octahedral NiCo<sub>2</sub>O<sub>4</sub>/MIL-Fe<sub>53<... |
39942318 | Surface-Modification Strategy to Produce Highly Anticorrosive Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene-Based Polymer Composite Coatings: A Mini-Review. | MXenes are a group of novel two-dimensional (2D) materials with merits such as large specific surface area, abundant surface-functional groups, high chemical activity, excellent mechanical properties, high hydrophilicity, and good compatibility with various polymers. In recent years, many novel high-performance organic... |
39942320 | Layer-by-Layer Nanoarchitectonics: A Method for Everything in Layered Structures. | The development of functional materials and the use of nanotechnology are ongoing projects. These fields are closely linked, but there is a need to combine them more actively. Nanoarchitectonics, a concept that comes after nanotechnology, is ready to do this. Among the related research efforts, research into creating f... |
39941855 | Curcumin and Its Derivatives in Hepatology: Therapeutic Potential and Advances in Nanoparticle Formulations. | Curcumin, a plant-derived polyphenol, shows promise in hepatology for treating both malignant and non-malignant liver diseases and a subset of extrahepatic cancers. Curcumin has hepatoprotective, anti-inflammatory, antifibrotic, and antiproliferative properties, as is evident in preclinical and clinical studies. This h... |
39941620 | Thalassemias and Sickle Cell Diseases in Pregnancy: SITE Good Practice. | <b>Background:</b> Hereditary hemoglobin disorders are the most common globally distributed monogenic red cell diseases. The rights of women with thalassemia or sickle cell disease (SCD) to motherhood need to be protected by creating a roadmap to guide her, and her family network, along all the phases of the event. In ... |
39941048 | The Pivotal Role of LACTB in the Process of Cancer Development. | The mitochondrial serine β-lactamase-like protein LACTB has emerged as a critical regulator in cancer biology, distinguished by its unique structural and functional attributes. Defined by its conserved penicillin-binding proteins and β-lactamases (PBP-βLs) domain and SXXK catalytic motif, LACTB demonstrates properties ... |
39938362 | Simultaneous and instrument-free detection of quinine and crystal violet based on a dual-emissive Eu<sup>3+</sup>-functionalized metal-organic framework. | Simultaneous detection and quantification of multi-targets is a challenge using one single sensor in the complicated environment of real samples. Herein, we developed a dual-emissive sensor (EuUCHNA) that selectively and rapidly responds to crystal violet (CV) and quinine (QN), two commonly used anti-infective drugs fo... |
39937661 | AnnCovDB: a manually curated annotation database for mutations in SARS-CoV-2 spike protein. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been circulating and adapting within the human population for >4 years. A large number of mutations have occurred in the viral genome, resulting in significant variants known as variants of concern (VOCs) and variants of interest (VOIs). The spike (S) pro... |
39936636 | Mechanistic Evaluation of Anti-CD19 CAR-T Cell Therapy Repurposed in Systemic Lupus Erythematosus Using a Quantitative Systems Pharmacology Model. | CAR-T cell therapy, renowned for its success in oncology, is now venturing into the realm of B cell-mediated autoimmune diseases. Recent observations have revealed significant pharmacological effects of CD19 CAR-T cells in patients with systemic lupus erythematosus (SLE), suggesting promising applications in other auto... |
39936349 | Highly Efficient Numerical Method for Modeling Mofs Containing Transition Metal Ions. | Employing a group-function based semiempirical approach, a new program package ΣHΘΩ $$ \varSigma H\varTheta \varOmega $$ (seethoo), targeted to modeling of metal-organic frameworks (MOFs) containing transition metal ions (TMIs) with open d-shells is developed. In this proof of concept study it is shown that the ΣHΘΩ... |
39933902 | Chirooptical 2,2'-Dimethoxybiphenyl Crystals Generated From Suzuki-Miyaura Coupling Reaction Catalyzed by Pd-Loaded Chiral Silica. | In this work, we report a one-pot approach that combines crystal ripening with the Suzuki-Miyaura coupling reaction. We investigated the reaction between 2-methoxyphenyl bromide and 2-methoxyphenylboronic acid, catalyzed by a series of Pd-loaded chiral optical (<sub>D</sub>- or <sub>L</sub>-) and racemic (<sub>DL</sub>... |
39933695 | Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation. | Transcriptional regulation involves interactions between transcription factors, coregulators, and DNA. Intrinsic disorder is a major player in this regulation, but mechanisms driven by disorder remain elusive. Here, we address molecular communication within the stress-regulating Arabidopsis thaliana transcription facto... |
39931755 | ISG15-Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans. | Type I interferon (IFN) signalling induces the expression of several hundred IFN-stimulated genes (ISGs) that provide an unfavourable environment for viral replication. To prevent an overexuberant response and autoinflammatory disease, IFN signalling requires tight control. One critical regulator is the ubiquitin-like ... |
39929704 | A novel complex of pectin-crosslinked β-cyclodextrin: Effectively reducing cholesterol content in hotpot beef tallow. | The high cholesterol content of beef tallow is one of the potential risks affecting the nutritional value and safety of beef tallow hotpot. In this study, a novel pectin-crosslinked β-cyclodextrin (β-CD) complex was successfully prepared by the cross-linking method to reduce the cholesterol content in beef tallow. When... |
39928802 | Advances in controlled release drug delivery systems based on nanomaterials in lung cancer therapy: A review. | Lung cancer is one of the most common malignant tumors, with the highest morbidity and mortality rates. Currently, significant progress has been made in the treatment of lung cancer, which has effectively improved the overall prognosis of patients, but there are still many problems, such as tumor recurrence, drug resis... |
39928796 | Construction and validation of a prediction nomogram model for acute gastrointestinal failure in patients with severe traumatic brain injury. | This study aims to establish and validate the prediction model of acute gastrointestinal failure (AGF) in patients with severe traumatic brain injury. A total of 665 inpatients from Shaoxing People's Hospital from January 2018 to January 2024 were admitted and randomly divided into training group (466 cases) and valida... |
39928527 | Increased Steroidogenic Acute Regulatory Protein Contributes to Cholesterol-induced β-Cell Dysfunction. | Hypercholesterolemia is often observed in individuals with type 2 diabetes. Cholesterol accumulation in subcellular compartments within islet β-cells can result in insulin secretory dysfunction, which is a key pathological feature of diabetes. Previously, we demonstrated that expression of the mitochondrial cholesterol... |
39927629 | Mechanisms and Manifestations of Group B Streptococcus Meningitis in Newborns. | Group B Streptococcus (GBS; Streptococcus agalactiae) is a gram-positive colonizer of the healthy intestinal and genitourinary microbiota. During and shortly after birth, neonates and infants can be opportunistically infected leading to sepsis, pneumonia, or meningitis among other illnesses. GBS is the leading cause of... |
39926652 | The effect of serum cortisol level on the outcomes of Persistent Inflammation, Immunosuppression and Catabolism Syndrome patients in the intensive care unit. | <h4>Objective</h4>This study sought to elucidate the potential association between serum cortisol level and clinical outcomes in patients diagnosed with Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS).<h4>Methods</h4>This prospective observational study, initiated in January 2023 and conclud... |
39921464 | Prodomain processing controls BMP-10 bioactivity and targeting to fibrillin-1 in latent conformation. | Bone morphogenetic protein 10 (BMP-10) is crucial for endothelial cell signaling via activin receptor-like kinase 1 (ALK1), a pathway central to vascular homeostasis and angiogenesis. Dysregulated BMP-10 signaling contributes to cardiovascular diseases and cancer, highlighting the need to control ALK1-mediated endothel... |
39921246 | Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice. | Influenza infections are often complicated by secondary bacterial infections such as MRSA pneumonia, which increase morbidity and mortality. Viral infections lead to an inflammatory response that includes elevated levels of IL-6 and interferons. IL-6 activates the JAK/STAT signaling pathway, amplifying downstream infla... |
39918987 | Crosstalk between cyclic-di-guanosine monophosphate and the sensor kinase MtrB regulates MtrA-dependent genes, bacterial growth, biofilm formation and lysosomal trafficking of <i>Mycobacterium tuberculosis</i>. | Cyclic-di-guanosine monophosphate (c-di-GMP) plays an important role in bacterial signalling networks. C-di-GMP exerts a regulatory function through binding to diverse molecules that include transcription factors, riboswitches and sensor kinases (SKs), thereby regulating diverse processes. Here, we demonstrate the cros... |
39917189 | Error evaluation of partial scattering functions obtained from contrast-variation small-angle neutron scattering. | Contrast-variation small-angle neutron scattering (CV-SANS) is a powerful tool to evaluate the structure of multi-component systems by decomposing the scattering intensities <i>I</i> measured with different scattering contrasts into partial scattering functions <i>S</i> of self- and cross-correlations between component... |
39917056 | Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment. | Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing a crucial role in its progression and treatment response. This review investigates the potential of nanoparticles to modulate the immune microenvironment in breast cancer therapy. Initially, we discuss the composition an... |
39914298 | P-doped and cyano-modified carbon nitride nanotubes for photocatalytic hydrogen evolution coupled with bisphenol A degradation. | The integration of photocatalytic wastewater treatment with solar-driven hydrogen (H<sub>2</sub>) evolution offers a clean and sustainable solution for wastewater treatment by simultaneously purifying wastewater and generating clean energy. Consequently, this method has garnered increasing attention. Graphitic carbon n... |
39912499 | The first step of cyanine dye self-assembly: Dimerization. | Self-assembling amphiphilic cyanine dyes, such as C8S3, are promising candidates for energy storage and optoelectronic applications due to their efficient energy transport properties. C8S3 is known to self-assemble in water into double-walled J-aggregates. Thus far, the molecular self-assembly steps remain shrouded in ... |
39911261 | A New Nanocomposite for Inducing Demineralized Dentin Remineralization. | <h4>Objective</h4>This study aimed to investigate a method for promoting the remineralization of demineralized dentin collagen fibers, with the objective of enhancing the bonding strength and durability of dentin resin while reducing the incidence of secondary caries.<h4>Methods</h4>A mineralized solution, PAMAM-COOH/A... |
39911260 | Highly Stable Antitumor Silver-Lipid Nanoparticles Optimized for Targeted Therapy. | <h4>Background</h4>Silver nanoparticles (AgNPs) have a broad spectrum of biocidal effects, allowing also their antitumor application. To enhance bioavailability, minimize adverse effects and enable targeted drug delivery AgNPs may be encapsulated in liposomes. In this study we aimed to create highly stable and effectiv... |
39908958 | Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis. | The inflammatory response is the core mechanism of the pathogenesis and symptoms of ulcerative colitis (UC), and inhibiting inflammation is a promising therapeutic approach to improving UC. Curcumin is considered a potential treatment for UC due to its significant anti-inflammatory and antioxidant effects. However, its... |
39907035 | A Phase 2 Study of Sotigalimab, a CD40 Agonist Antibody, plus Concurrent Chemoradiation as Neoadjuvant Therapy for Esophageal and Gastroesophageal Junction Cancers. | <h4>Purpose</h4>Neoadjuvant chemoradiation (NCRT) followed by surgical resection represents a standard approach for patients with locally advanced esophageal/gastroesophageal junction (GEJ) cancers. Sotigalimab is a high-affinity CD40 agonist antibody capable of inducing and expanding antitumor immune responses by acti... |
39902916 | Dynamic changes in microbial communities during sweet flour sauce fermentation and their correlations with physicochemical properties and volatile compounds. | Sweet flour sauce is a traditional fermented condiment in China, known for its distinct sweet and savory flavor profile. During the fermentation process, the dominant bacterial genera were Ralstonia and Bacillus, and the dominant fungal genera were Aspergillus, Issatchenkia, Clavispora, and Zygosaccharomyces. In additi... |
39902686 | Potential distribution theory of alchemical transfer. | We present an analytical description of the Alchemical Transfer Method (ATM) for molecular binding using the Potential Distribution Theory (PDT) formalism. ATM models the binding free energy by mapping the bound and unbound states of the complex by translating the ligand coordinates. PDT relates the free energy and the... |
39902679 | Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4. | The sodium pump Na+/K+-ATPase (NKA), an enzyme ubiquitously expressed in various tissues and cells, is a critical player in maintaining cellular ion homeostasis. Dysregulation of α1 subunit of NKA (NKAα1) has been associated with cardiovascular and metabolic disorders, yet the exact role of NKAα1 in diabetes-induced en... |
39901924 | Multi-scale computational modeling to identify novel chemical scaffolds as trehalose-6-phosphate phosphatase inhibitors to combat <i>Burkholderia pseudomallei</i>. | <i>Burkholderia pseudomallei</i> causes melioidosis, a deadly infection having high fatality rates (20-50%) and antibiotic resistance, however, there's no effective drug or vaccine available. Trehalose is a vital sugar for <i>B. pseudomallei</i> which influences the pathogen resilience and pathogenicity. This proposed ... |
39901768 | Small Extracellular Vesicles Engineered Using Click Chemistry to Express Chimeric Antigen Receptors Show Enhanced Efficacy in Acute Liver Failure. | Acetaminophen (APAP) overdose can cause severe liver injury and life-threatening conditions that may lead to multiple organ failure without proper treatment. N-acetylcysteine (NAC) is the accepted and prescribed treatment for detoxification in cases of APAP overdose. Nonetheless, in acute liver failure (ALF), particula... |
39901737 | Stoichiometric constraints for detection of EV-borne biomarkers in blood. | Stochiometric issues, encompassing both the quantity and heterogeneity of extracellular vesicles (EVs) derived from tumour or other tissues in blood, pose important challenges across various stages of biomarker discovery and detection, affecting the integrity of data, introducing losses and artifacts during blood proce... |
39900147 | Biophysical and molecular interactions of enantiomeric piperonal-derived trans β-aryl-δ-iodo-γ-lactones with cancer cell membranes, protein and DNA: Implications for anticancer activity. | Developing novel anticancer agents requires understanding their interactions with biological systems at both the cellular and molecular levels. Enantiomeric lactones have demonstrated notable cytotoxic activities against various cancer cell lines. Building on this foundation, we investigated enantiomeric piperonal-deri... |
39894105 | Study on the preparation and properties of lignin-based flexible polyurethane foams with NaCl as a medium. | Currently, most polyols used in polyurethane foam (PUF) synthesis are derived from petrochemicals. However, lignin as the most abundant aromatic biopolymer rich in hydroxyl groups, is a suitable filler for synthesizing polyurethane foam. Therefore, in this study, Kraft lignin (KL) was utilized as a partial substitute f... |
39894042 | Conventional versus Instillation Negative-Pressure Wound Therapy for Severe Soft Tissue Injury in Open Pelvic Fractures: A Retrospective Review. | <h4>Purpose</h4>We investigated the clinical features, current negative-pressure wound therapy (NPWT) management strategies, and outcomes of pelvic-perineal soft tissue infection after open pelvic fractures.<h4>Materials and methods</h4>We analyzed the data of patients admitted to our trauma center with pelvic-perineal... |
39893477 | Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer. | Limited therapeutic options are available for patients with platinum-resistant ovarian cancer (OC). Herein, we developed gallium sulfide-embedded bovine serum albumin nanoformulations (Ga<sub>2</sub>S<sub>3</sub>-BSA NMs) with a size of ~ 11 nm via a self-assembly approach. As the nanoformulations degraded in an acidic... |
39893448 | Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery. | Plant-derived nanovesicles (PDVs) as nanodrug delivery carriers have gained recognition due to their satisfactory biosafety. However, there remains a challenge to target tumor sites accurately due to the uncertain membrane protein components on the surface of vesicles. Herein, a composite nanodrug delivery system by en... |
39893419 | Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics. | Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and enhancing the stability and ... |
39893369 | A comparative analysis of sequence composition in different lots of a phage display peptide library during amplification. | <h4>Background</h4>To develop efficient selection strategies and improve the discovery of promising ligands, it is highly desirable to analyze the sequence composition of naïve phage display libraries and monitor the evolution of their peptide content during successive rounds of amplification. In the current study, we ... |
39893295 | Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract. | In a recent study, we used chemical analysis to show that the Caesalpinia mimosoides aqueous extract, which contains a high concentration of simple phenolics, has strong anti-influenza activity. We determined through molecular docking methods that its potential target inhibitor is the neuraminidase. Therefore, our stud... |
39893189 | Enlarging moment and regulating orientation of buried interfacial dipole for efficient inverted perovskite solar cells. | Carrier transport and recombination at the buried interface of perovskite have seriously restricted the further development of inverted perovskite solar cells (PSCs). Herein, an interfacial dipolar chemical bridge strategy to address this issue is presented. 2-(Diphenylphosphino) acetic acid (2DPAA) is selected as the ... |
39891857 | Excellent Laccase Mimic Activity of Cu-Melamine and Its Applications in the Degradation of Congo Red. | Copper-based nanozyme has shown the superior in the oxidase-like activities due to its electron transfer ability between the Cu(I) and Cu(II) sites during the catalytic reactions. Herein, a Cu(I)-MOF (Cu-Mel) was readily synthesized by a traditional hydrothermal process using the precursors of Cu<sup>+</sup> and melami... |
39891818 | New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite. | Pancreatic cancer is an extremely deadly illness for which there are few reliable treatments. Recent research indicates that malignant tumors are highly variable and consist of a tiny subset of unique cancer cells, known as cancer stem cells (CSCs), which are responsible for the beginning and spread of tumors. These ce... |
39891799 | Hydrazine imprinted electrochemical sensor based on cobalt-barium stannate nanoparticles incorporated-functionalized MWCNTs nanocomposite for hydrazine determination in tap water samples. | A hydrazine (HYD) detection method is presented based on molecularly imprinting polymers (MIPs) and cobalt-barium stannate nanoparticles incorporated-functionalized MWCNTs (CBSNPs/f-MWCNTs) nanocomposite. Firstly, co-precipitation and sonication techniques were applied to the preparations of CBSNPs and CBSNPs/f-MWCNTs ... |
39891789 | High-loading Bi-MOF nanoparticles anchored on biomass waste-derived carbon for sensitive non-enzymic nitrite sensing. | A novel electrocatalyst based on loofah sponge-derived carbon-supported high-density Bi-MOF nanoparticles was designed and used for electrochemical nitrite detection. The use of conductive loofah sponge-derived carbon substrate to support Bi-MOF nanoparticles can not only accelerate electron transfer, thereby accelerat... |
39891738 | A network aggregation model for amyloid- β dynamics and treatment of Alzheimer's diseases at the brain scale. | Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend ... |
39891733 | Vitamin and dietary supplements are not associated with total or cardiovascular mortality in Switzerland: the CoLaus|PsyCoLaus prospective study. | <h4>Purpose</h4>Vitamin-mineral and dietary supplements (VMDS) are taken by a large fraction of the population. Whether their long-term consumption impacts mortality and cardiovascular disease (CVD) has seldom been studied.<h4>Methods</h4>Prospective study from a population-based cohort from Lausanne, Switzerland. Part... |
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