id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
39775379 | Water-soluble platinum and palladium porphyrins with peripheral ethyl phosphonic acid substituents: synthesis, aggregation in solution, and photocatalytic properties. | Water-soluble porphyrins have garnered significant attention due to their broad range of applications in biomedicine, catalysis, and material chemistry. In this work, water-soluble platinum(II) and palladium(II) complexes with porphyrins bearing ethyl phosphonate substituents, namely, Pt/Pd 10-(ethoxyhydroxyphosphoryl)... |
39760398 | Impact of cerium doping on the peroxidase-like activity of metal-organic frameworks. | Hydrogen peroxide, phenols, amines, aldehydes, and other substances can easily damage intracellular biomacromolecules. Although natural peroxidases can convert these harmful substances into benign ones, the high costs, poor stabilities, and stringent application conditions associated with these enzymes necessitate the ... |
39757957 | Shape-responsive host-guest chemistry: metal-free tetracationic porphyrin nonplanarity promoted by clay mineral interactions assessed by theoretical simulations. | Distortions in the porphyrin core from planarity can trigger a unique structure-property relationship, imparting its basicity, chemical stability, redox potential, and excited-state energetics, among other properties. The colour change promoted by such distortion is signed by red shifts in its electronic absorption spe... |
39750063 | A High-Performance Electrochemical Sensor Based on Ni-Pt Bimetallic Nanoparticles Doped Metal Organic Framework ZIF-8 for the Detection of Dopamine. | In this paper, microporous Zn-based zeolitic imidazolate framework with the sodalite cage structure (SOD-ZIF-8) was synthesized by the solvothermal method. Powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and N<sub>2</sub> adsorption were employed to characterize the synthesized material. An ultra-se... |
39692098 | What happened to BBR3464 and where to from here for multinuclear platinum-based anticancer drugs? | The development of the trinuclear platinum(II) complex BBR3464 (also known as triplatin) in the late 1990s was meant to be a revolution in the field of platinum chemotherapy. What made it remarkable was that it defied many of the known structure-activity rules for platinums; it is cationic, has a single labile <i>trans... |
39600190 | Cracking down on vapochromic salts: unveiling vapomechanical stress in gas-sorbing platinum complexes. | This study explores the vapochromic and vapoluminescent behaviors of [Pt(tpy)Cl]PF<sub>6</sub> host molecules (tpy = 2,2':6',2''-terpyridine) under acetonitrile (CH<sub>3</sub>CN) vapor guest, challenging the conventional view that these phenomena arise solely from direct host-guest interactions. Our findings reveal a ... |
40657200 | Anti-Inflammatory Treatment of Subarachnoid Hemorrhage by Self-Assembled Silymarin Nanoparticles. | Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and high mortality. Early brain injury (EBI) is the main cause of high mortality and delayed neurological dysfunction in patients with SAH. Neuroinflammation is the important pathological processes of EBI.We prepared... |
40621125 | Machine learning-assisted microfluidic approach for broad-spectrum liposome size control. | Liposomes serve as critical carriers for drugs and vaccines, with their biological effects influenced by their size. The microfluidic method, renowned for its precise control, reproducibility, and scalability, has been widely employed for liposome preparation. Although some studies have explored factors affecting lipos... |
40395341 | Kinetic Pathway Control in the Synthesis of Well-Defined Ruthenium Coordination Oligomers. | Ruthenium complexes with 2,2'-bipyridine-6,6'-dicarboxylate (bda) ligands have emerged as highly potent catalysts for water oxidation. In this context, the accumulation of active Ru centers in macrocyclic arrays or coordination oligomers and polymers has proven to be very beneficial for an enhanced stability under oper... |
40196322 | Sodium alginate coated ferritin as ACE inhibitory peptide carrier: Prolonged release property and enhanced transepithelial transport. | The application of Ala-His-Leu-Leu (AHLL), an angiotensin converting enzyme (ACE) inhibitory peptide, is limited due to its low stability. In this work, horse spleen apoferritin (HSF) deposited with a layer of sodium alginate (SA) was employed to carry AHLL. The HSF encapsulation and SA decoration exhibited remarkable ... |
40182657 | Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing. | Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. Herein, an iron-based metal-organic framework loaded with gold (Fe-MIL-88NH<sub>2</... |
40060893 | Membrane modification strategies for virus removal from water. | Membrane technology, through innovative approaches such as nanocomposite membranes, membrane bioreactors, and electrocatalytic membrane reactors, offers a synergistic platform for pathogen removal. This review examines recent advancements in membrane modifications aimed at optimizing virus removal efficiency. It outlin... |
40027263 | Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection. | Recombinant adeno-associated virus (rAAV) is a leading vector for retinal gene therapy due to its favorable safety profile demonstrated by the FDA-approved Luxturna for Leber congenital amaurosis. However, challenges with low transduction efficiency and immunogenicity, coupled with the invasiveness of subretinal inject... |
40017759 | Optical Axial Chirality Enhancement and Transfer within Aromatic Micelles upon (Co-)encapsulation. | Axial chirality is the key physiochemical element, yet its chiroptical utilities have been largely limited to covalent synthesis and infinitely assembled systems so far. Here we report a new application of axially chiral binaphthyls for efficient, optical chirality enhancement and transfer upon noncovalent encapsulatio... |
40007779 | Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies. | Human papillomavirus (HPV) contributes to a high global incidence of sexually transmitted infections, predominantly associated with cervical cancer, as well as head and neck, penile, anal, vaginal, and vulvar cancers. Despite efforts through improved screening and HPV vaccination campaigns, challenges persist, influenc... |
40006020 | Breakthrough Advances in Beta-Lactamase Inhibitors: New Synthesized Compounds and Mechanisms of Action Against Drug-Resistant Bacteria. | Beta-lactam drugs hold a central place in the antibacterial arsenal, and the production of beta-lactamases by drug-resistant bacteria has severely compromised the effectiveness of nearly all available beta-lactams. Therefore, in the face of the increasing threat of drug resistance, the combined use of beta-lactamase in... |
40001523 | The Inhibitory Effect of Peptide Hydrolysate of Type I Collagen Derived from Pig Skin on Melanogenesis in B16F10 Melanoma Cells. | Collagen peptides, as a natural source of peptides, possess multiple advantages such as anti-aging, anti-inflammatory properties, tissue repair, and the ability to inhibit melanin production. In this study, type I collagen extracted from pig skin was hydrolyzed with 1% and 3% hydrochloric acid, yielding collagen peptid... |
39995902 | High-performance electrochemical sensor based on Pt-Ag@Cu-BDC MOF composite modified glassy carbon electrode for detection of imidacloprid in citrus juice and water samples. | The key factor to improve the sensitivity of electrochemical sensors for direct detection, is the introduction of new nanomaterials with enhanced catalytic properties. Accordingly, we prepared Pt-Ag@Cu-metal organic framework (MOF) as a novel nanocomposite to construct a sensitive electrochemical sensor for voltammetri... |
39995466 | Efficacy of <i>Larimichthys crocea</i> TASOR protein-derived peptide FAM286 against <i>Staphylococcus aureus</i>. | <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is a major foodborne pathogen, could lead cause of intestinal infections in humans. Antimicrobial peptides, as emerging antimicrobial agents, are gradually replacing traditional agents due to their highly effective and safe antimicrobial activity. In this study, a novel p... |
39995409 | Trends in extraction and purification methods of Lignans in plant-derived foods. | Lignans are widely used as dietary supplements within health foods. However, excess addition of lignans can induce adverse reactions, therefore, it is necessary to develop rapid, effective, economical, and environmentally friendly extraction and purification methods to enhance lignan extraction efficiency. Recently, th... |
39995401 | Decoding the specific minty-like aroma of 'Rucheng baimaocha' (<i>camellia pubescens</i>) black tea. | Rucheng Baimaocha (<i>Camellia pubescens</i>) black tea (RCBT) exhibits floral and sweet attributes with a unique minty-like aroma, distinguishing it from traditional and other innovative black teas. However, its key odorants remain unknown. In this study, gas chromatography-olfactometry (GC-O) combined with aroma extr... |
39990741 | The anti-depression effect and mechanism of harmonious rosemary essential oil and its application in microcapsules. | Depression imposes a heavy burden on patients and society, and current antidepressants often cause side effects such as dryness in the mouth and constipation. The explorations about aromatic plant essential oils provide a new method for the treatment of depression, but the mechanisms of antidepressant effect of these o... |
39990674 | Antibody-dependent enhancement of coronaviruses. | The COVID-19 pandemic presents a significant challenge to the global health and the world economy, with humanity engaged in an extended struggle against the virus. Notable advancements have been achieved in the development of vaccines and therapeutic interventions, including the application of neutralizing antibodies (... |
39989827 | Save Your Tears for the Toxicity Assays-Carbon Nanotubes Still Fooling Scientists. | The extensive study of carbon nanotube (CNT) toxicity stems from their widespread application across various fields. The toxicity of CNTs is commonly assessed using cell viability assays based on tetrazolium salts, such as the MTT assay. ISO 10993-5 outlines the MTT assay and related <i>in vitro</i> cytotoxicity tests ... |
39989821 | Nanofluids for Advanced Applications: A Comprehensive Review on Preparation Methods, Properties, and Environmental Impact. | Nanofluids, an advanced class of heat transfer fluids, have gained significant attention due to their superior thermophysical properties, making them highly effective for various engineering applications. This review explores the impact of nanoparticle integration on the thermal conductivity, viscosity, and overall hea... |
39989816 | Novel Coumarin-Substituted Cyclophosphazene as a Fluorescent Probe for Highly Selective Detection of 2,4,6-Trinitrophenol. | Nitroaromatic compounds (NACs) such as 2,4,6-trinitrophenol (TNP), commonly known as picric acid (PA), hold widespread application in industries such as dyestuff production, wood preservation, explosives manufacturing, insect control, and photographic development. In this study, the organic-inorganic hybrid 4,4',4″,4‴,... |
39989768 | Newer Therapeutic Approaches in Treating Alzheimer's Disease: A Comprehensive Review. | Alzheimer's disease (AD) is an aging-related irreversible neurodegenerative disease affecting mostly the elderly population. The main pathological features of AD are the extracellular Aβ plaques generated by APP cleavage through the amyloidogenic pathway, the intracellular neurofibrillary tangles (NFT) resulting from t... |
39989760 | PAPreC: A Pipeline for Antigenicity Prediction Comparison Methods across Bacteria. | Antigenicity prediction plays a crucial role in vaccine development, antibody-based therapies, and diagnostic assays, as this predictive approach helps assess the potential of molecular structures to induce and recruit immune cells and drive antibody production. Several existing prediction methods, which target complet... |
39986769 | Encapsulated hesperetin modulates inflammatory responses in an in vitro intestinal immune co-culture model. | In vitro cell models are an effective way to evaluate the biological activities of functional compounds. Hesperetin (HST) is a flavanone with various potential health-related benefits, and encapsulation improved its stability and bioavailability. This study aimed to investigate the anti-inflammatory effects of encapsul... |
39982317 | Differential Signaling Pathways Identified in Aqueous Humor, Anterior Capsule, and Crystalline Lens of Age-Related, Diabetic, and Post-Vitrectomy Cataract. | <b>Background</b>: The purpose of this study was to detect proteomic alterations and corresponding signaling pathways involved in the formation of age-related cataract (ARC), diabetic cataract (DC), and post-vitrectomy cataract (PVC). <b>Methods</b>: Three sample types, the aqueous humor (AH), the anterior capsule (AC)... |
39981221 | Electroconductive Bionanocomposites from Black Soldier Fly Proteins for Green Flexible Electronics. | Printed and flexible electronics hold the potential to revolutionize the world of electronic devices. A primary focus today is their circularity, which can be achieved by using biobased materials. In this study, electrically conductive bionanocomposite materials suitable for flexible electronics were fabricated using p... |
39974744 | Fluorinated Block Copolymer: An Important Sorbent Design Criteria for Effective PFOA Removal from Its Aqueous Solution. | An important question remains unresolved, despite extensive studies on polymer-based sorbents for adsorbing poly and perfluoro alkyl substances (PFAS): How does the positioning of the fluorine-rich segment in polymer affect PFAS removal? Herein, we designed a linear, uncharged triblock copolymer incorporating a fluorin... |
39963674 | Fresh-cut watermelon: postharvest physiology, technology, and opportunities for quality improvement. | Watermelon (<i>Citrullus lanatus</i> L.) fruit is widely consumed for its sweetness, flavor, nutrition and health-promoting properties. It is commonly commercialized in fresh-cut format, satisfying consumer demand for freshness and convenience, but its shelf-life is limited. Despite the potential for growth in fresh-cu... |
39963354 | Investigation of photophysical properties and potential biological applications of substituted tris(polypyridyl)ruthenium(II) complexes. | The photophysical properties of tris(polypyridyl)ruthenium(II) complex [Ru(dmbpy)<sub>3</sub>]<sup>2+</sup> [dmbpy = 4,4'-dimethyl-2,2'-bipyridine] were investigated and compared with [Ru(bpy)<sub>3</sub>]<sup>2+</sup> following both experimental and computational approaches. The variations in the electronic properties... |
39963115 | Tight junction proteins in glial tumors development and progression. | Tight junctions form a paracellular barrier in epithelial and endothelial cells, and they regulate the diffusion of fluids, molecules, and the penetration of cells across tissue compartments. Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tight junction-associat... |
39944610 | Effect of P-doped bimetallic FeCo catalysts on a carbon matrix for oxygen reduction in alkaline media. | Catalysts' redox reactions are crucial for storage and energy conversion. Therefore, the fabrication of cost-effective, structurally rational, and multifunctional advanced catalytic materials continues to be a crucial task. In this study, we obtained P, Fe, and Co co-doped, nitrogen-rich carbon nanofibers by directly f... |
39943010 | An Investigation into the Biological Activities of Four Lamiaceae Essential Oils Against <i>Thrips flavus</i>, Crops, and Weeds. | In recent years, with the increasing awareness of environmental protection and food safety, essential oils (EOs) have gained significant attention as safer and more environmentally friendly alternatives. This study investigated the insecticidal activity of four Lamiaceae EOs (patchouli oil, catnip oil, lavender oil, an... |
39942768 | Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review. | Quinones, one of the oldest organic compounds, are of increasing interest due to their abundant presence in a wide range of natural sources and their remarkable biological activity. These compounds occur naturally in green leafy vegetables, fruits, herbs, animal and marine sources, and fermented products, and have demo... |
39942777 | Small but Mighty: A Microfluidic Biofuel Cell-Based Biosensor for the Determination of Ethanol. | We developed a membraneless-microfluidic biofuel cell (MBFC) for the quantification of ethanol. The system employs anolyte and catholyte solutions, each containing a biocatalyst and redox mediator. The laminar flow conditions in the microfluidic chip minimize the mixing between anolyte and catholyte and obviate the nee... |
39942342 | Insights into HKUST-1 Metal-Organic Framework's Morphology and Physicochemical Properties Induced by Changing the Copper(II) Salt Precursors. | The HKUST-1 metal-organic framework was synthesized using four different copper(II) salt precursors, namely copper nitrate, copper sulphate, copper acetate, and copper chloride, via the solvothermal method with no mixing. Syntheses were conducted without using the N,N-dimethylformamide to allow for a greener synthesis ... |
39942079 | Advances in Spray-Drying and Freeze-Drying Technologies for the Microencapsulation of Instant Tea and Herbal Powders: The Role of Wall Materials. | The microencapsulation of tea and herbal extracts is gaining considerable attention in the food industry, particularly in the production of instant powders. This review examines the application of spray-drying and freeze-drying technologies for the encapsulation of bioactive compounds, focusing on the role of wall mate... |
39941072 | Exploiting Silica-Binding and Silica-Forming Proteins as Versatile Tools for One-Step Enzyme Immobilization on Siliceous Materials. | Enzyme immobilization has emerged as an essential technique in industrial applications of enzymes. Silica (SiO<sub>2</sub>) serves as a prominent support material for enzyme immobilization. Recent advancements have led to the development of various silica-binding proteins (SBPs) and silica-forming proteins (SFPs) that ... |
39941062 | Biological Significance and Therapeutic Promise of Programmed Ribosomal Frameshifting. | Programmed Ribosomal Frameshifting (PRF) is a mechanism that alters the mRNA reading frame during translation, resulting in the production of out-of-frame proteins. PRF plays crucial roles in maintaining cellular homeostasis and contributes significantly to disease pathogenesis, particularly in viral infections. Notabl... |
39940603 | Implantable Polymer Scaffolds Loaded with Paclitaxel-Cyclodextrin Complexes for Post-Breast Cancer Tissue Reconstruction. | The side effects associated with the chemotherapy of triple-negative breast cancer (TNBC), such as nucleotide-binding oligomerization domain (NOD)-like receptor family (NLR), pyrin domain containing 3 (<i>NLRP3</i>) inflammasome activity, are responsible for the treatment failure and high mortality rates. Therefore, ad... |
39938325 | On the thermal and chemical stability of DNAJB6b and its globular domains. | The chaperone DNAJB6b (JB6) plays important roles in increasing amyloid protein solubility and inhibiting amyloid fibril formation, a causative factor for neurodegenerative diseases like Alzheimer's and Parkinson's disease. Insights into the biophysical properties of JB6, including its structure, self-assembly and stab... |
39935500 | Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN. | Fluorescent nucleobase analogues (FBAs) have emerged as powerful tools for understanding nucleic acid systems at the molecular level. However, their application at the single-molecule level has been limited by low brightness and an incomplete understanding of how local chemical environments affect their properties. In ... |
39925931 | Mechanism of Mongolian Medicine Batri-7 on <i>Salmonella</i> Enteritis. | <h4>Purpose</h4>Traditional Mongolian Medicine Batri-7 (BT-7) is the key Mongolian Medicine (MM) for bacterial enteritis. BT-7 is a well-known clinical MM due to its antibacterial properties. BT-7 contains plant-derived bioactive compounds, but its molecular mechanism of action remains unclear. This study explores BT-7... |
39925683 | Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease. | Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, primarily arises from defects in the colonic barrier, imbalances of the gut microbiota, and immune response issues. These complex causes make it difficult to achieve a complete cure. Patients with IBD frequently experience recurrent abd... |
39925679 | Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones. | Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions and pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, the field of nanomedicine is undergoing significant ad... |
39925678 | Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy. | Breast cancer is one of the most common types of cancer in women worldwide and is a leading cause of cancer deaths among women. As a result, various treatments have been developed to combat this disease. Breast cancer treatment varies based on its stage and type of pathology. Among the therapeutic options, ultrasound h... |
39923492 | Interactions between heme and G-quadruplex DNA involve the oxygen of guanine. | Guanine quadruplexes are non-canonical DNA structures with various functions including transcription and translation regulation and telomere protection. These structures are known to bind the heme prosthetic group, resulting in heme-bound G-quadruplexes (heme-G4) that exhibit enhanced peroxidase activity and act as pro... |
39921973 | Immunomagnetic metal-organic frameworks based coupling-free and extraction-free sensitive detection of aflatoxin B<sub>1</sub> in peanut oils. | Conventional AFB<sub>1</sub> detection methods are hindered by cumbersome pretreatment procedures, primarily due to the lack of new sample pretreatment materials and technologies. This work developed a novel coupling-free synthesis strategy for the immunomagnetic metal-organic frameworks (IMMOFs), focusing on its effec... |
39909374 | Modulation of the substrate preference of a MYST acetyltransferase by a scaffold protein. | The MYST family of lysine acetyltransferases are transcriptional regulators often dysregulated in cancer. In cells, MYST members form distinct multiprotein complexes that guide their histone substrate specificity, but how this selectivity is conferred is not fully understood. Here we interrogate a complex-mediated chan... |
39909137 | Effects of poly(amidoamine) as an extrafibrillar demineralization agent on dentin bonding durability of deciduous teeth. | <h4>Objectives</h4>To investigate the effects of the sixth generation of poly(amidoamine) (G6-PAMAM)-based extrafibrillar demineralization on bonding durability of deciduous dentin and explore the possible mechanisms.<h4>Methods</h4>The cytotoxicity and inhibitory effects on recombinant human matrix metalloproteinases-... |
39907403 | Nanomaterial application for protein delivery in bone regeneration therapy. | Bone fractures must undergo a complex healing process involving intricate cellular and molecular mechanisms. They require a suitable biological environment to restore skeletal stability and resolve inflammation. Scaffolds play a vital role in bone regeneration, thus reducing disease burden. Autologous bone graft repres... |
39906377 | Electron-deficient two-dimensional poly(arylene vinylene) covalent organic frameworks: efficient synthesis and host-guest interaction. | Crystalline and porous 2D poly(arylene vinylene)s (2D PAVs), <i>i.e.</i> vinylene-linked 2D conjugated covalent organic frameworks, represent promising materials for electronic and electrochemical applications. Chemically robust 2D PAVs with strong electron affinity are highly desirable for effective host-guest charge ... |
39905730 | The deubiquitinase USP28 maintains the expression of PPARγ and its inactivation protects mice from diet-induced MASH and hepatocarcinoma. | Metabolic dysfunction-associated steatohepatitis (MASH), a progressive form of metabolic dysfunction-associated fatty liver disease (MAFLD), is a leading cause of liver disease worldwide and can progress to cirrhosis and cancer. Despite its prevalence, the pathogenesis of MASH remains poorly understood, and there is on... |
39902347 | Terahertz Metamaterials Inspired by Quantum Phenomena. | The study of many phenomena in the terahertz (THz) frequency spectral range has emerged as a promising playground in modern science and technology, with extensive applications in high-speed communication, imaging, sensing, and biosensing. Many THz metamaterial designs explore quantum physics phenomena embedded into a c... |
39901621 | Breaking barriers: Smart vaccine platforms for cancer immunomodulation. | Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great the... |
39901592 | Susceptibility of Brca1<sup>(L63X/+)</sup> rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer. | BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk of early-onset breast cancer. Whereas olaparib (OLA), an inhibitor of poly-ADP-ribose polymerase, has been applied as adjuvant therapy to those cancer patients, its effect on ovarian reproductive function remains unel... |
39901531 | A Simple and Efficient Non-Noble Cathode Catalyst Based on Carbon Hollow Nanocapsules Containing Cobalt-Based Materials for Anion Exchange Membrane Water Electrolyzer. | An efficient approach for fabrication of non-noble metal-based electrocatalyst is desirable for designing the energy storage and conversion devices in real-world usages due to low cost and excellent catalytic properties. The preparation of hollow carbon capsules (HCC) containing cobalt (Co)-based electrocatalyst is rep... |
39901519 | Interfacial Nanoengineering of Hydrogel Surfaces via Block Copolymer Self-Assembly. | Synthetic polymer hydrogels are valuable matrices for biotransformations, drug delivery, and soft implants. While the bulk properties of hydrogels depend on chemical composition and network structure, the critical role of interfacial features is often underestimated. This work presents a nanoscale modification of the g... |
39901501 | Supramolecular Engineering of Vinylene-Linked Covalent Organic Framework - Ruthenium Oxide Hybrids for Highly Active Proton Exchange Membrane Water Electrolysis. | The controlled formation of a functional adlayer at the catalyst-water interface is a highly challenging yet potentially powerful strategy to accelerate proton transfer and deprotonation for ultimately improving the performance of proton-exchange membrane water electrolysis (PEMWE). In this study, the synthesis of robu... |
39901482 | Photonic Nanomaterials for Wearable Health Solutions. | This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized health monitoring. Their unique optical and physical properties enable rapid, precise, and sensitive real-time monitoring, outperforming conventional electrical-b... |
39901481 | Highly Specific and Sensitive SERS Detection of Putrescine Using Au Nanobowls@Cu-MOF Embedded in a Hydrogel Nanoreactor. | Putrescine is of concern due to its toxicity and applications in monitoring food spoilage and water quality. However, it is difficult to realize highly selective and sensitive detection of putrescine with interferences from other biogenetic amines with similar molecular structures. In this work, Au nanobowls modified b... |
39901478 | Trace Dual-Crosslinkable Additives Enable Direct Microlithography for Enhanced Organic Electrochemical Transistors. | Similar to silicon-based electronics, the implementation of micro/nano-patterning to facilitate complex device architectures and high-density integration is crucial to the development of organic electronics. Among various patterning techniques, direct microlithography (DML) is highly applicable and extensively adopted ... |
39901476 | Nature Inspired Delivery Vehicles for CRISPR-Based Genome Editing. | The advent of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based genome editing technologies has opened up groundbreaking possibilities for treating a wide spectrum of genetic disorders and diseases. However, the success of these technologies relies heavily on the development of efficient and safe... |
39901475 | Decoding Framework Dynamics in a Spin Crossover Flexible Metal-Organic Framework. | Functional spin crossover (SCO) metal-organic frameworks (MOFs) hold promise for miniaturized spin-based devices due to their tuneable molecule-based properties near room temperature. SCO describes the phenomenon where transition metal ions switch between high spin (HS) and low spin (LS) states upon external stimuli. H... |
39901461 | A Library of Polyphenol-Amino Acid Condensates for High-Throughput Continuous Flow Production of Nanomedicines with Ultra-High Drug Loading. | Synthesizing high drug-loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large-scale engineered production of such nanomedicines presents even greater difficulties. This study presents a scalable library of polyphenol-amino acid condensates. By selecting amino acids... |
39901378 | Unlocking Disease-Modifying Treatments for TDP-43-Mediated Neurodegeneration. | Neurons degenerate in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), causing progressive and inevitably fatal neurological decline. The best therapeutic strategies target underlying disease mediators, but after decades of intensive research, the causes of these neurodegenerative diseases remain ... |
39901370 | Size Effect and Interfacial Synergy Enhancement of 2D Ultrathin Co<sub>x</sub>Zn<sub>1-x</sub>-MOF/rGO for Boosting Lithium-Sulfur Battery Performance. | Advanced cathode materials are developed to tackle the challenges of the polysulfide shuttle effect and slow sulfur redox kinetics in Li-S batteries. A particularly effective strategy is the creation of nanostructured sulfur-host, which boast high levels of conductivity and catalytic activity. Here, a series of ultrath... |
39901329 | Novel Electrochemical Sensor Based on Cu-MOF/MWCNT-COOH for the Simultaneous Detection of Ascorbic Acid and Dopamine. | By utilizing carboxylated multiwalled carbon nanotubes (MWCNT-COOH) to strengthen the interaction between the electrode and the analytes and improve the conductivity of the composite material and in conjunction with the superior catalytic properties of copper-based metal-organic framework (MOFs), a novel electrochemica... |
39901272 | Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia. | <h4>Background</h4>Over the last decades, universal health coverage (UHC) has been promoted in south-east Asia (SEA), where many countries still need to ensure adequate financial protection to their populations. However, successful health financing reforms involve complex interactions among a range of stakeholders, as ... |
39901245 | Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps. | <h4>Background</h4>Steroid-resistant asthma (SRA) is a form of asthma resistant to corticosteroid therapy, which is characterized by the presence of neutrophil-predominant inflammatory response and neutrophil extracellular traps (NETs) formation. Hyssopus cuspidatus Boriss., a traditional Uyghur medicine, is known for ... |
39901199 | Transcriptomic analysis of Rhipicephalus microplus hemocytes from female ticks infected with Babesia bovis or Babesia bigemina. | <h4>Background</h4>Tick hemolymph is a sterile fluid that carries nutrients to maintain tick health. The hemolymph creates a hostile environment for invaders including the destruction of microorganisms by its circulating hemocytes. However, Babesia parasites escape and disseminate to other organs through the hemolymph ... |
39901077 | Comprehensive genome-wide analysis of ARF transcription factors in orchardgrass (Dactylis glomerata): the positive regulatory role of DgARF7 in drought resistance. | Auxin response factor (ARF), a transcription factor, is crucial in controlling growth, development, and response to environmental stress. Orchardgrass (Dactylis glomerata) is an economically significant, widely cultivated forage grass. However, information on the genome-wide information and functional characterization ... |
39900984 | Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development. | MtbClpC1 is a promising drug target against tuberculosis. Recent studies have shown that several natural product antibiotics targeting the unfoldase N-terminal domain can impair MtbClpC1 function resulting in cell death. While the pharmacological properties of these natural product antibiotics prevent their use in the ... |
39900959 | Cost-effective adsorption of cationic dyes using ZnO nanorods supported by orange peel-derived carbon. | Here, porous carbon (PC) and ZnO nanorods@PC (ZnO-NR@PC) composite derived from orange peel (OP) have been synthesized via a simple carbonization process. The prepared materials have been characterized by XRD, FT-IR, TEM, and BET analysis. The adsorptive properties of the prepared PC and ZnO-NR@PC composite have been i... |
39900935 | New advances in biological preservation technology for aquatic products. | Aquatic products, characterized by their high moisture content, abundant nutrients, and neutral pH, create an optimal environment for the rapid proliferation of spoilage organisms, lipid oxidation, and autolytic degradation. These factors collectively expedite the spoilage and deterioration of aquatic products during s... |
39900924 | Diffusion-programmed catalysis in nanoporous material. | In the realm of heterogeneous catalysis, the diffusion of reactants into catalytically active sites stands as a pivotal determinant influencing both turnover frequency and geometric selectivity in product formation. While accelerated diffusion of reactants can elevate reaction rates, it often entails a compromise in ge... |
39900923 | Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites. | Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate the impact of plant-derived nanoparticles (PNP) on gut microbiota and metabolites in context of cancer immunotherapy with the humanized ... |
39900911 | Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP<sub>(1,2)</sub> in a position elevated from the virion membrane. | Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP<sub>1,2</sub>) are the standard of care for Ebola virus disease (EVD). Anti-GP<sub>1,2</sub> mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV in vitro and are protective in a mouse model of EVD. Howeve... |
39900882 | Facile synthesis of MIL-100(Fe) adsorbents for boosting organic dye removal. | Highly effective MIL-100(Fe) adsorbent material was successfully synthesized from (NH<sub>4</sub>)<sub>2</sub>Fe(SO<sub>4</sub>)<sub>2</sub>·6H<sub>2</sub>O and H<sub>3</sub>BTC precursors under mild conditions. Characteristics regarding crystal structure, functional groups, elemental composition, surface morphology, s... |
39900822 | Neddylation of RhoA impairs its protein degradation and promotes renal interstitial fibrosis progression in diabetic nephropathy. | Diabetic nephropathy (DN) is a common and serious complication of diabetes, characterized by chronic fibro-inflammatory processes with an unclear pathogenesis. Renal fibrosis plays a significant role in the development and progression of DN. While recent research suggests that the neddylation pathway may influence fibr... |
39900665 | Devaluing memories of reward: a case for dopamine. | Midbrain dopamine cells encode differences in predictive and expected value to support learning through reward prediction error. Recent findings have questioned whether reward prediction error can fully account for dopamine function and suggest a more complex role for dopamine in encoding detailed features of the rewar... |
39900639 | An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice. | The literature documenting the value of drug-like molecules found in natural products is vast. Although many dietary and herbal remedies have been found to be effective for treating intestinal inflammation, the identification of their active components has lagged behind. In this study, we find that a major ginger compo... |
39900620 | Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors. | Nucleic acid therapeutics are used for silencing, expressing or editing genes in vivo. However, their systemic stability and targeted delivery to bone marrow resident cells remains a challenge. In this study we present a nanotechnology platform based on natural lipoproteins, designed for delivering small interfering RN... |
39900608 | Contrastive-learning of language embedding and biological features for cross modality encoding and effector prediction. | Identifying and characterizing virulence proteins secreted by Gram-negative bacteria are fundamental for deciphering microbial pathogenicity as well as aiding the development of therapeutic strategies. Effector predictors utilizing pre-trained protein language models (PLMs) have shown sound performance by leveraging ex... |
39900594 | Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system. | Carbon monoxide (CO) poisoning is one of the most common causes of injury and death from poisoning. The primary objective of therapy is to eliminate CO from the patient as quickly as possible to prevent acute and long-term effects. The ideal treatment is hyperbaric oxygen in a pressure chamber. However, pressure chambe... |
39900586 | Thiophene-fused aromatic belts. | Aromatic belts, ultrashort carbon nanotubes, and related structures, are emerging molecular entities in the fields of organic electronics and supramolecular chemistry owing to their structural rigidity, fully fused π-conjugation, and well-defined cavity. Synthesis of aromatic belts with embedded thiophene structures, w... |
39900576 | Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates. | In the realm of biology, peptide bonds are formed via reactive phosphate-containing intermediates, facilitated by compartmentalized environments that ensure precise coupling and folding. Herein, we use aminoacyl phosphate esters, synthetic counterparts of biological aminoacyl adenylates, that drive selective peptide bo... |
39900574 | Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer. | Plasma membrane macromolecular complexes function as signaling hubs that regulate cell behavior, which is particularly relevant in cancer. Our study provides evidence that the complex formed by the hERG1 potassium channel and the β1 subunit of integrin receptors preferentially localizes in Lipid Rafts (LRs) in Pancreat... |
39900570 | Proton-electron coupling and mixed conductivity in a hydrogen-bonded coordination polymer. | The fundamental understanding of coupled proton-electron transport in mixed protonic-electronic conductors (MPECs) remains unexplored in materials science, despite its potential significance within the broader context of mixed ionic-electronic conductors (MIECs) and the possibility of controlled diffusion of protons us... |
39900568 | Structural insights into dynamics of the BMV TLS aminoacylation. | Brome Mosaic Virus (BMV) utilizes a tRNA-like structure (TLS) within its 3' untranslated region to mimic host tRNA functions, aiding aminoacylation and viral replication. This study explores the structural dynamics of BMV TLS interacting with tyrosyl-tRNA synthetase (TyrRS) during aminoacylation. Using cryo-EM, we capt... |
39900541 | Amorphous PdRuO<sub><i>x</i></sub> as High-Activity Sensitizers for Ultrafast Low-Humidity Sensors. | Amorphous noble metals often display excellent sensitization due to their unsaturated atomic coordination and abundant active sites on the surface. In this work, amorphous palladium-ruthenium bimetallic nanoparticles were successfully prepared by lithium doping and incorporated into MOF-303 by using a confinement strat... |
39900533 | Photoswitchable Molecular Motor Phospholipid: Synthesis, Characterization, and Integration into Lipid Vesicles. | Lipid membranes are essential for cellular function, acting as barriers and platforms for major cellular and biochemical activities. The integration of photoisomerizable units into lipid structures allows for tunable membrane properties, offering insights into major membrane-related processes. In this study, we present... |
39900524 | Adeno-Associated Virus Self-Assembled with Tannic Acid and Phenylboronic Acid Polymers to Evade Neutralizing Antibodies and Reduce Adverse Events. | Adeno-associated viruses (AAVs) are increasingly used in gene therapy to treat debilitating genetic diseases. However, systemically administered AAVs are often inactivated by neutralizing antibodies (NAbs), and high-dose administration of AAVs causes hepatotoxicity, which limits their effectiveness. To address these ch... |
39900437 | Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease. | The plasma membrane covering the primary cilium has a diverse accumulation of receptors and channels. To ensure the sensor function of the cilia, the ciliary membrane has higher cholesterol content than other cell membrane regions. A peroxisomal biogenesis disorder, Zellweger syndrome, characterized by polycystic kidne... |
39899845 | Bioavailability of Food Polyphenols: Current State of Knowledge. | (Poly)phenols, including flavonoids, phenolic acids, and tannins, are a diverse class of compounds found in plant-based foods and beverages. Their bioavailability has been extensively described and detailed metabolic pathways elucidated. Although some parent (poly)phenols are absorbed intact in the small intestine, mos... |
39899736 | Versatile and Controlled Synthesis of Degradable, Water-Soluble Bottlebrush Polymers with Poly(disulfide) Backbones Derived from α-Lipoic Acid. | Bottlebrush (BB) polymers, with their densely grafted side chains and unique architecture, are highly advantageous for drug delivery due to their high functional group density for drug conjugation, unimolecular nature, and enhanced biodistribution properties. These attributes enable extended blood circulation half-life... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.