id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
39891057 | Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis. | Sepsis is associated with immune dysregulated and organ dysfunction due to severe infection. Clinicians aim to restore organ function, rather than prevent diseases that are prone to sepsis, resulting in high mortality and a heavy public health burden. Some chronic diseases can induce sepsis through inflammation cascade... |
39890884 | Fragment optimized chalcone derivatives targeting OmpA protein as a therapeutic approach against multidrug resistant Acinetobacter baumannii. | Acinetobacter baumannii is a notorious pathogen associated with life-threatening infections, with its outer membrane protein A (OmpA) being a key contributor to its pathogenicity by targeting epithelial cell apoptosis. The study presents an in silico analysis of chalcone derivatives as potential therapeutic agents agai... |
39890852 | Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers. | New insulin drug delivery systems (IDDs): insulin@chitin; insulin@chitin-grafted (g)-guar gum were prepared by using a modified sol-gel method. Insulin vials were loaded on the safe natural inert bioactive polymers (chitin and chitin-g-GG copolymer) carriers using water green solvent. Traces amount additives were below... |
39890820 | Chiral polypeptide hydrogels regulating local immune microenvironment and anti-tumor immune response. | The impact of chirality on immune response has attracted great interest in cancer vaccine research recently. However, the study of chiral synthetic polypeptide hydrogels as cancer vaccines as well as of the impact of biomaterials themselves for antitumor immunotherapy has rarely been reported. Here, we show the key rol... |
39890804 | Methylcobalamin protects against liver failure via engaging gasdermin E. | Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific GSDME inhibitor and highly effective against cholestatic liver fa... |
39890793 | Investigating new drugs from marine seaweed metabolites for cervical cancer therapy by molecular dynamic modeling approach. | The etiology of cervical cancer in women is attributed to the continuous infection of the human papillomavirus (HPV). The high costs and side effects of standard treatments and the limited efficacy of HPV vaccination have led to a quest for novel, cost-effective cervical cancer treatments, particularly in middle- and l... |
39890785 | Contact ion-pair S<sub>N</sub>2 reactions activated by Lewis Base Phase transfer catalysts. | We present experimental probes of contact ion-pair (CIP) S<sub>N</sub>2 reactions for simplest prototype systems by <sup>19</sup>F-NMR spectroscopy. This study provides crucial evidences for the reactions of CIP metal salts facilitated by Lewis base phase transfer catalysts (PTCs) [2,2,2]-cryptand, 18-crown-6, pentaeth... |
39890678 | Microfluidic synthesis of gold nanoparticle-doped microspherical photonic crystal as SERS substrate for methylene blue detection. | A novel microfluidic approach is presented for the one-step synthesis of gold nanoparticle-doped microspherical photonic crystal (AuNP-MPC) for ultrasensitive surface-enhanced Raman spectroscopy (SERS) detection of methylene blue (MB), a common environmental pollutant. The AuNP-MPC microspheres exhibited excellent SERS... |
39890664 | Deciphering the Distinct Associations of Rhizospheric and Endospheric Microbiomes with Capsicum Plant Pathological Status. | Exploring endospheric and rhizospheric microbiomes and their associations can help us to understand the pathological status of capsicum (Capsicum annuum L.) for implementing appropriate management strategies. To elucidate the differences among plants with distinct pathological status in the communities and functions of... |
39890654 | Carbon dot-ZIF-67-infused tragacanth hydrogel films: leveraging tunable luminescence through displacement mechanisms for anthrax detection. | A novel method for 2,6-Pyridine dicarboxylic acid (DPA) detection is introduced using red emissive carbon dots (r-CDs) derived from amaranth leaves and Eosin Yellow (EY), encapsulated within a Co-based MOF (ZIF-67). The approach utilizes ratiometric turn-on fluorescence and visual identification of DPA through a displa... |
39890628 | Fe<sub>3</sub>O<sub>4</sub>-Cu-BTC/MWCNTs modified electrodes for real-time chlorine monitoring in aqueous solution. | A efficient sensor is presented for detecting free chlorine in water by decorating glassy carbon electrodes (GCE) via multi-walled carbon nanotubes (MWCNTs) and Fe<sub>3</sub>O<sub>4</sub>-Cu-BTC composite. After the characterization of prepared materials by field emission scanning electron microscopy (FE-SEM), energy-... |
39890622 | Enhanced solid-liquid synergistic microextraction of nine bisphenols in serum using polyaniline functionalized metal-organic framework nanocomposites/methyl tert-butyl ether. | Bisphenols, as a new class of environmental endocrine disruptors (EED), can interfere with the endocrine system of the human body and lead to various diseases. In this study, a novel polyaniline functionalized metal-organic framework (PANI@MIL-101@HF) was synthesized by utilizing hollow fibers (HF) as the the immobiliz... |
39889237 | Self-assembling Depsipeptides on Aggregation-Induced Emission Luminogens: A New Way to Create Programmable Nanovesicles and Soft Nanocarriers. | We introduce the proof of concept of a new methodology to produce robust hollow nanovesicles stable in water or mixtures of water and organic solvents. The bottom-up produced nanovesicles are formed by the self-assembly of depsipeptide chains of natural origin combined with new aggregation-induced emission luminogens t... |
39888987 | Mechanisms of uropathogenic <i>E. coli</i> mucosal association in the gastrointestinal tract. | Urinary tract infections (UTIs) are highly recurrent and frequently caused by Uropathogenic <i>Escherichia coli</i> (UPEC) strains that can be found in patient intestines. Seeding of the urinary tract from this intestinal reservoir likely contributes to UTI recurrence (rUTI) rates. Thus, understanding the factors that ... |
39888985 | Adapting hybrid density functionals with machine learning. | Exact exchange contributions significantly affect electronic states, influencing covalent bond formation and breaking. Hybrid density functional approximations, which average exact exchange admixtures empirically, have achieved success but fall short of high-level quantum chemistry accuracy due to delocalization errors... |
39888973 | Pair combinations of human monoclonal antibodies fully protected mice against bunyavirus SFTSV lethal challenge. | Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever caused by a tick-borne virus SFTSV with a mortality rate of up to 30%. Currently, there is no vaccine or effective therapy for SFTS. Neutralizing monoclonal antibody therapy, which provides immediate passive immunity and may limit disease p... |
39888835 | Antiplatelet Effects of DMPC-Based Synthetic High-Density Lipoproteins: Exploring Particle Structure and Noncholesterol Efflux Mechanisms. | Platelet activation is a key factor in the development of cardiovascular diseases. High-density lipoprotein (HDL) is known for its cardioprotective activities including antithrombotic actions. While HDL mimetics have been explored for their potential to regulate thrombosis, their influence on platelet activity remains ... |
39888613 | Formation and evaluation of doxorubicin and cromoglycate metal-organic framework for anti-cancer activity. | <h4>Aims</h4>We develop and evaluate copper-based metal-organic frameworks (Cu-MOFs) incorporating cromolyn as a linker to enhance structural stability, drug delivery efficiency, and therapeutic potential, particularly for breast cancer treatment.<h4>Materials & methods</h4>Two Cu-MOF formulations were synthesized: Cu-... |
39888535 | Advanced Bismuth-Based Anode Materials for Efficient Potassium Storage: Structural Features, Storage Mechanisms and Modification Strategies. | Potassium-ion batteries (PIBs) are considered as a promising energy storage system owing to its abundant potassium resources. As an important part of the battery composition, anode materials play a vital role in the future development of PIBs. Bismuth-based anode materials demonstrate great potential for storing potass... |
39888498 | Early administration of romosozumab prevents rebound of bone resorption related to denosumab withdrawal in fractured post-menopausal women: a real-world prospective study. | <h4>Purpose</h4>The real-world effectiveness of switching from denosumab to romosozumab remains controversial. Sequential therapy with romosozumab was shown to be associated with inadequate suppression of bone resorption and there was anecdotal evidence of major osteoporotic fractures (MOFs) after transitioning from de... |
39888410 | Microbiological findings in a cohort of patients with coronavirus disease 2019 and venovenous extracorporeal membrane oxygenation. | <h4>Background</h4>Venovenous extracorporeal membrane oxygenation (VV ECMO) is an established support option for patients with very severe respiratory failure and played an important role during the coronavirus disease 2019 (COVID-19) pandemic. Bacteria and fungi can lead to severe infectious complications in criticall... |
39888402 | The candidate gene SibHLHA regulates anthocyanin-driven purple pigmentation in Sesamum indicum flowers. | Anthocyanins not only serve as critical pigments determining floral hues but also play essential roles in attracting insects for pollination, feeding animals and mitigating abiotic stress. However, the molecular mechanisms underlying the regulation of flower color in sesame has not yet been reported. In this study, an ... |
39888369 | [First fracture in patients with osteoporosis : How does the "fracture career" of our patients with osteoporosis begin?] | <h4>Background</h4>Given that a primary osteoporotic fracture can result in subsequent fractures and that the precise etiology of the typical fracture cascade remains uncertain, it is pertinent to determine the initiating factor and the specific fracture involved in this cascade.<h4>Method</h4>All patients with a fract... |
39888289 | Facet-Dependent Cold Welding of Au Nanorods Revealed by Liquid Cell Transmission Electron Microscopy. | Cold welding of metals at the nanoscale has been demonstrated to play a significant role in bottom-up manufacturing and self-healing processes of nanostructures and nanodevices. However, the welding mechanism at the nanoscale is not well understood. In this study, a comprehensive demonstration of the cold welding proce... |
39888194 | Photoacids and Photobases: Applications in Functional Dynamic Systems. | Brønsted photoacids and photobases are a unique class of molecules that undergo a major change in their pK<sub>a</sub> values between their ground and excited states, resulting in donating or accepting a proton, respectively, but only after light excitation. This property of photoacids/photobases makes them an attracti... |
39888023 | Heavy Atom as a Molecular Sensor of Electronic Density: The Advanced Dimer-Type Light-Emitting System for NIR Emission. | The approaches to design and control intermolecular interactions for a selective enhancement of specific process(es) are of high interest in technologies using molecular materials. Here, we describe how π-π stacking enables control over the heavy-atom effect and spin-orbit coupling (SOC) through dimerization of an orga... |
39887897 | Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair. | Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects the tissue regeneration efficiency and wellness of patients. Piezoelectric materials exhibit the outstanding advantage of producing electrons without external power supply. The ability of electron enrichment and reactive o... |
39887893 | Untwisting Strategy of MOF Nanosheets in Ultrathin Film Membrane for High Molecular Separation Performance. | Oriented 2D metal-organic framework (MOF) membranes hold considerable promise for industrial separation processes. Nevertheless, the lattice misalignment caused by the twisted stacking of 2D nanosheets reduces the in-plane pore size and exerts a significant impact on the membrane separation performance. Precisely regul... |
39887652 | Inversion of Circularly Polarized Luminescence in the Left-Handed Chitosan-Templated Co-assemblies. | Circularly polarized luminescence (CPL) materials are attractive due to their unique applications in fields such as 3D displays, information encryption, and chiroptical switches. Natural biomolecules-based CPL materials are gaining plenty of attention due to their chiral diversity and sustainability. However, it is sti... |
39887649 | Integrating Humidity-Resistant and Colorimetric COF-on-MOF Sensors with Artificial Intelligence Assisted Data Analysis for Visualization of Volatile Organic Compounds Sensing. | Direct visualization and monitoring of volatile organic compounds (VOCs) sensing processes via portable colorimetric sensors are highly desired but challenging targets. The key challenge resides in the development of efficient sensing systems with high sensitivity, selectivity, humidity resistance, and profuse color ch... |
39887647 | A Dual-Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide-Induced Sepsis. | Sepsis is an underappreciated yet severe threat to human life, marked by organ dysfunction and high mortality resulting from disordered inflammatory responses to blood infection. Unfortunately, no specific drugs are available for effective sepsis treatment. As a pivotal biomarker for sepsis, lactate levels are closely ... |
39887646 | Unveiling the Li/Electrolyte Interface Behavior for Dendrite-Free All-Solid-State Lithium Metal Batteries by Operando Nano-Focus WAXS. | Poly(ethylene oxide) (PEO)-based solid composite electrolytes suffer from poor conductivity and lithium dendrite growth, especially toward the metallic lithium metal anode. In this study, succinonitrile (SN) is incorporated into a PEO composite electrolyte to fabricate an electrode-compatible electrolyte with good elec... |
39887644 | MOF Nanosheet Enable Accelerated Redox Kinetics and Ultralow Overpotential for Light-Assisted Li-CO<sub>2</sub> Battery. | Lithium-carbon dioxide (Li-CO₂) batteries have attracted much attention due to their high energy density, low cost, and carbon sequestration. However, the sluggish conversion kinetics between CO₂ and the discharge product lithium carbonate (Li₂CO₃) have hindered their practical applications. Herein, a flower-like photo... |
39887619 | Multi-Step Assembly of an RNA-Liposome Nanoparticle Formulation Revealed by Real-Time, Single-Particle Quantitative Imaging. | Self-assembly plays a critical role in nanoparticle-based applications. However, it remains challenging to monitor the self-assembly of multi-component nanomaterials at a single-particle level, in real-time, with high throughput, and in a model-independent manner. Here, multi-color fluorescence microscopy is applied to... |
39887611 | Rational Pore Design in Multivariate Metal-Organic Frameworks for C<sub>2</sub>H<sub>6</sub>/C<sub>2</sub>H<sub>4</sub> Separation. | The arrangement of pores within the framework plays a crucial role in the gas separation and adsorption of metal-organic frameworks (MOFs), determining their overall performance. In this study, the impact on gas separation efficiency is compared using two multivariate MOF (MTV-MOF) systems with controlled pore arrangem... |
39887545 | Exploration of Multidimensional Structural Optimization and Regulation Mechanisms: Catalysts and Reaction Environments in Electrochemical Ammonia Synthesis. | Ammonia (NH<sub>3</sub>) is esteemed for its attributes as a carbon-neutral fuel and hydrogen storage material, due to its high energy density, abundant hydrogen content, and notably higher liquefaction temperature in comparison to hydrogen gas. The primary method for the synthetic generation of NH<sub>3</sub> is the H... |
39887339 | Beyond the mono-nucleosome. | Nucleosomes, the building block of chromatin, are responsible for regulating access to the DNA sequence. This control is critical for essential cellular processes, including transcription and DNA replication and repair. Studying chromatin can be challenging both in vitro and in vivo, leading many to use a mono-nucleoso... |
39887190 | Co-Ni/C Composite Derived from N, S-Codoped Graphene Decorate Metal-Organic Framework toward Microwave Attenuation. | Metal-organic frameworks (MOFs) exhibit highly adjustable porosity, structure, and versatility, properties that render them promising for electromagnetic wave (EMW) absorption applications. However, the impedance matching of these composites is poor in practical applications, thereby compromising their EMW absorption p... |
39887132 | Rationally Engineered Bispecific Nanoimmunoblocker Restores Anticancer Immunity via Dual Immune Checkpoint Blockade. | Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment. However, the outcomes of mainstay antibody inhibitors against solid tumors remain poor, facing tremendous challenges including manufacturing complexities, serious toxicities, and crosstalk among multiple checkpoints. Herein, we present a bisp... |
39887017 | Versatile nanomaterials used in combatting biofilm infections. | Microbial infections are a pressing global health issue, exacerbated by the rise of antibiotic-resistant bacteria due to widespread antibiotic overuse. This resistance diminishes the effectiveness of current treatments, intensifying the need for new antimicrobial agents and innovative drug delivery strategies. Nanotech... |
39887014 | Revisiting the Facet Control in the Growth of Au Nanobipyramids. | Abnormalities of Au nanobipyramids (NBPs), such as rough surfaces, variable tip angles, corrugated edges, and curved tips, cannot be explained by traditional facet control. The underlying mechanism and significance of these abnormalities have not been fully recognized. This study revisits the growth process, focusing o... |
39886922 | Dendrimer-Mediated Molecular Sieving on Avidin. | Decoration of proteins and enzymes with well-defined polymeric structures allows precise decoration of protein surfaces, enabling controlled modulation of activity. Here, the impact of dendronization on the interaction between avidin and biotin was investigated. A series of generation 3-7 bis(2,2-hydroxymethyl)propioni... |
39886846 | Nanoscale Metal-Organic Frameworks for the Co-Delivery of Cycloxaprid and Pooled siRNAs to Enhance Control Efficacy in <i>Diaphorina citri</i>. | RNA pesticides have emerged as a promising alternative to conventional chemical pesticides due to their high specificity and minimal environmental impact. However, the instability of RNA molecules in the environment and the challenges associated with their effective delivery to target pests limit their broader applicat... |
39883764 | Transforming achiral semiconductors into chiral domains with exceptional circular dichroism. | Highly concentrated solutions of asymmetric semiconductor magic-sized clusters (MSCs) of cadmium sulfide, cadmium selenide, and cadmium telluride were directed through a controlled drying meniscus front, resulting in the formation of chiral MSC assemblies. This process aligned their transition dipole moments and produc... |
39868968 | Emergence of a novel reassortant highly pathogenic avian influenza clade 2.3.4.4b A(H5N2) Virus, 2024. | Reassortant highly pathogenic avian influenza A(H5N2) clade 2.3.4.4.b viruses were detected from ducks and environmental samples in Egypt, June 2024. Genomic and phylogenetic analyses revealed a novel genotype produced by the reassortment of an A(H5N1) clade 2.3.3.4b virus with an A(H9N2) G1-like virus. Monitoring the ... |
39854087 | Controlling the J- and H-Aggregates and Supramolecular Polymerization Pathways of Anthanthrene by Tuning the Hydrogen Bonding Sites. | Exploration of new π-conjugated building blocks for construction of supramolecular polymers is at the forefront of self-assembly. Herein, we incorporate a highly planar anthanthrene skeleton into the design of two supramolecular monomers 1 and 2. Their supramolecular polymerization have been comprehensively investigate... |
39853808 | In Situ Electron Paramagnetic Resonance Investigation of Isotope-Selective Breathing in MIL-53 During Dihydrogen Adsorption. | The development of smart materials capable of separating dihydrogen isotopologues has risen recently. Among potential candidates, the flexible MIL-53 (Al) has been gaining attention due to its structural flexibility providing the so-called ''breathing mechanism'' that can be useful to separate hydrogen isotopologues se... |
39846498 | Creating Dual Active Sites in Ru-doped FeMn-MOF-74 for Efficient Overall Water Splitting. | The design of well-engineered bifunctional electrocatalysts is crucial for achieving durable and efficient performance in overall water splitting. In this study, Ru-doped FeMn-MOF-74 itself has Ru sites and generates FeMnOOH under catalytic conditions, forming dual active sites for overall water splitting. Density func... |
39841576 | Next-Generation Photosensitizers: Cyanine-Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer. | Photodynamic therapy (PDT) has emerged as a promising targeted treatment for cancer. However, current PDT is limited by low tissue penetration, insufficient phototoxicity (toxicity with light irradiation), and undesirable cytotoxicity (toxicity without light irradiation). Here, we report the discovery of cyanine-carbor... |
39835584 | Hysteresis Photomodulation within Photochromic Assemblies of [Dy(Tp<sup>2-py</sup>)F]<sup>+</sup> Single-Molecule Magnets : Influence of the Supramolecular Magnetic Couplings. | A 1D coordination compound made of a photochromic dithienylethene linker and [Dy(Tp<sup>2-py</sup>)F]<sup>+</sup> units (with Tp<sup>2-py</sup>=tris(3-(2-pyridyl)pyrazolyl)hydroborate) and having tetrakis[3,5-bis(trifluoromethyl)phenyl]borate counterions is reported. Full photoconversion from the closed isomer to the o... |
39835384 | Amine-Functionalized Triazolate-Based Metal-Organic Frameworks for Enhanced Diluted CO<sub>2</sub> Capture Performance. | Efficient CO<sub>2</sub> capture at concentrations between 400-2000 ppm is essential for maintaining air quality in a habitable environment and advancing carbon capture technologies. This study introduces NICS-24 (National Institute of Chemistry Structures No. 24), a Zn-oxalate 3,5-diamino-1,2,4-triazolate framework wi... |
39832125 | Cu(I)-Induced G-Quartets: Robust Supramolecular Polymers Exhibiting Heating-Induced Aqueous Phase Transitions Into Gel or Precipitate. | Certain proteins and synthetic covalent polymers experience aqueous phase transitions, driving functional self-assembly. Herein, we unveil the ability of supramolecular polymers (SPs) formed by G<sub>4</sub>.Cu<sup>+</sup> to undergo heating-induced unexpected aqueous phase transitions. For the first time, guided by Cu... |
39822034 | Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein. | Amyloid self-assembly of α-synuclein (αSyn) is linked to the pathogenesis of Parkinson's disease (PD). Type 2 diabetes (T2D) has recently emerged as a risk factor for PD. Cross-interactions between their amyloidogenic proteins may act as molecular links. In fact, fibrils of islet amyloid polypeptide (IAPP) (T2D) can cr... |
39817459 | Isoleucine at position 137 of haemagglutinin acts as a mammalian adaptation marker of H9N2 avian influenza virus. | The H9N2 subtype of avian influenza virus (AIV) is widely distributed among poultry and wild birds and is also a threat to humans. During AIV active surveillance in Liaoning province from 2015 to 2016, we identified 10 H9N2 strains exhibiting different lethality to chick embryos. Two representative strains, A/chicken/C... |
41568089 | Long-Term Cell-Membrane-Coated Ultrabright Nanospheres for Targeted Cancer Cell Imaging and Hydrophobic Drug Delivery. | Nanoparticle-based imaging agents have gained massive attention for the targeted cancer cell imaging of early stage disease diagnosis. Among these, organic dye-entrapped and -assembled nanoparticles have been considered as potential imaging agents. However, they are limited by poor brightness, low stability, low reprod... |
40777790 | Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy. | Drug therapy, including chemotherapy and immunotherapy, remains a cornerstone of cancer treatment; however, significant toxic side effects are often unavoidable, inhibiting tumor growth while causing damage to multiple organ systems. Polymeric nanomedicines have shown substantial promise in addressing the limitations o... |
40046677 | Bistable Electrical Switching Using a Crown Ether-Based Monolayer Electrolyte on WSe<sub>2</sub> Field-Effect Transistors with Various Salts. | Bistable electrical switching using a crown-ether-based electrolyte on WSe<sub>2</sub> field-effect transistors (FETs) is measured for four salts: LiClO<sub>4</sub>, NaClO<sub>4</sub>, Ca(ClO<sub>4</sub>)<sub>2</sub>, and LiCl. The solid-state monolayer electrolyte comprises cobalt crown ether phthalocyanine in which c... |
40034967 | Development of multivalent CAR T cells as dual immunotherapy and conditioning agents. | Hematopoietic stem cell transplantation (HSCT) is the only definitive cure for pediatric acute myeloid leukemia (AML). Despite adjustments in HSCT protocols and improvements in supportive care, 30% of high-risk patients who receive HSCT as part of their therapy still experience disease relapse with high transplant-rela... |
40034274 | Multidimensional comparative analysis of wild and cultivated <i>Gentiana macrophylla</i> based on electronic intelligent sensory technology and chemical composition. | <i>Gentiana macrophylla radix</i>, is a renowned traditional Chinese medicine, has been widely utilized in various pharmaceutical applications. The increasing demand for this material has led to the widespread cultivation of the plant. However, the differences in chemical constituents between wild and cultivated <i>G. ... |
40017748 | Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensates. | Heat shock factor 1 (Hsf1), a hub protein in the stress response and cell fate decisions, senses the strength, type, and duration of stress to balance cell survival and death through an unknown mechanism. Recently, changes in the physical property of Hsf1 condensates due to persistent stress have been suggested to trig... |
40015789 | Magnetic supramolecular solvent based magnetic surfactant: Synthesis, physicochemical properties, and application. | <h4>Background</h4>Magnetic solvents have been recently introduced to reduce the time required for phase separation. Compared with magnetic materials, magnetic solvents show simpler preparation and better repeatability. These solvents have a strong response to external magnetic fields due to the presence of metal ions ... |
40006952 | Evolutionary Mechanisms of the Emergence of the Variants of Concern of SARS-CoV-2. | The evolutionary origin of the variants of concern (VOCs) of SARS-CoV-2, characterized by a large number of new substitutions and strong changes in virulence and transmission rate, is intensely debated. The leading explanation in the literature is a chronic infection in immunocompromised individuals, where the virus ev... |
40006543 | Exploring the Potential of Gold Nanoparticles in Proton Therapy: Mechanisms, Advances, and Clinical Horizons. | Proton therapy represents a groundbreaking advancement in cancer radiotherapy, leveraging the unique spatial energy distribution of protons to deliver precise, high-dose radiation to tumors while sparing surrounding healthy tissues. Despite its clinical success, proton therapy faces challenges in optimizing its therape... |
40006004 | <i>Alternaria alternata</i> (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication. | <b>Background/Objectives</b>: The development of HIV drug resistance to current antiretrovirals, and the antiretrovirals' inability to cure HIV, provides the need of developing novel drugs that inhibit HIV-1 subtypes and drug-resistance strains. Fungal endophytes, including <i>Alternaria alternata</i>, stand out for th... |
40002735 | High-Throughput Microfluidic Production of Ultrasmall Lecithin Nanoliposomes for High-Efficacy Transdermal Delivery and Skin-Aging Treatment. | <h4>Background</h4>Liposome particles with smaller sizes could increase transdermal drug delivery efficacy for enhanced skin penetration. While microfluidic methods have enabled controlled liposome synthesis, achieving efficient production of ultrasmall nanoliposomes (NLP<sub>US</sub>) with a size smaller than 40 nm ye... |
40002469 | Towards a New Dawn for Neuro-Oncology: Nanomedicine at the Service of Drug Delivery for Primary and Secondary Brain Tumours. | (1) Background/Objectives: Primary and secondary brain tumours often hold devastating prognoses and low survival rates despite the application of maximal neurosurgical resection, and state-of-the-art radiotherapy and chemotherapy. One limiting factor in their management is that several antineoplastic agents are unable ... |
40001501 | Order-to-Disorder and Disorder-to-Order Transitions of Proteins upon Binding to Phospholipid Membranes: Common Ground and Dissimilarities. | Cytochrome <i>c</i> is one of the most prominent representatives of peripheral membrane proteins. Besides functioning as an electron transfer carrier in the mitochondrial respiratory chain, it can acquire peroxidase capability, promote the self-assembly of α-synuclein, and function as a scavenger of superoxide. An unde... |
39997579 | Recent Advancements in Chitosan-Based Biomaterials for Wound Healing. | Chitosan is a positively charged natural polymer with several properties conducive to wound-healing applications, such as biodegradability, structural integrity, hydrophilicity, adhesiveness to tissue, and bacteriostatic potential. Along with other mechanical properties, some of the properties discussed in this review ... |
39974524 | Synergistic cryoprotective effects of mannan oligosaccharides and curdlan on the grass carp surimi. | The cryoprotective effects of mannan oligosaccharides (MOS) and curdlan (CU) on the quality of grass carp surimi after freeze-thaw cycles (FTCs) were assessed using the response surface methodology. The optimal contents of MOS (6.79 %, <i>w</i>/w) and CU (0.45 %, w/w) produced minimum thawing losses and the highest gel... |
39959117 | ENO1/Hsp70 Interaction Domains: In Silico and In Vitro Insight for a Putative Therapeutic Target in Cancer. | Alpha-enolase (ENO1) is a multifunctional protein with oncogenic roles. First described as a glycolytic enzyme, the protein performs different functions according to its cellular localization, post-translational modifications, and binding partners. Cell surface-localized ENO1 serves as a plasminogen-binding receptor, a... |
39959096 | Confinement-Driven Aggregate Formation of Photoacids within Porous Metal-Organic Frameworks. | Structurally driven properties of hybrid materials are a fascinating feature of metal-organic framework (MOF) materials that can serve as hosts for various responsive dye molecules. In particular, the formation of aggregates and the related shift of the emission of fluorophors can be tuned as a function of pore confine... |
39959083 | TREM-1 as a Potential Coreceptor in Norovirus Pathogenesis: Insights from Transcriptomic Analysis and Molecular Docking. | Norovirus (NoV) is a major cause of acute diarrheal disease in humans. However, due to complications in cultivating this virus, bioinformatics aids in elucidating the virus-host relationship. One of the molecules that has been associated with the burden of viral diseases is TREM-1, mainly due to its role in amplifying ... |
39959074 | Bimetallic ZIF-8 from Hydroxide Double Salts for Efficient Cu<sup>2+</sup> Removal in Wastewater. | Metal-organic frameworks (MOFs) hold significant potential for applications in gas adsorption and separation, catalysis, chemical sensing, and drug delivery. Zeolitic imidazolate frameworks (ZIFs) are a type of MOF composed of metal ions and imidazolate ligands, structurally similar to zeolite structures. ZIF-8, a wide... |
39950149 | Amebicidal and Antiadhesion Activities of <i>Knema retusa</i> Extract Against <i>Acanthamoeba triangularis</i> T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Against <i>Acanthamoeba</i> Beta-Tubulin. | Medicinal plants have been used as alternative agents for the treatment of infections. This study aimed to investigate bioactivities of medicinal plant extracts including <i>Knema retusa</i> extract (Kre) against <i>Acanthamoeba triangularis</i> T4 <i>in vitro</i> and <i>in silico</i>. Anti-<i>Acanthamoeba</i> activiti... |
39950132 | Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent. | In this study, a new MOF (metal-organic framework) based on vanadium and 2,2-bipyridine-4,4-dicarboxylic acid (V/BP-MOF) was synthesized. Synthesized V/BP-MOF was introduced as a strong adsorbent of Congo Red (CR) and an effective agent in eliminating microbial species. In the investigation of CR absorption activity, s... |
39950117 | Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders. | Lipid metabolism plays a crucial role in maintaining homeostasis and overall health, as lipids are essential molecules involved in bioenergetic processes. An increasing body of research indicates that disorders of lipid metabolism can contribute to the development and progression of various diseases, including hyperlip... |
39949861 | Microstructural modifications in bitumens rejuvenated by oil from pyrolysis of waste tires. | <h4>Introduction</h4>Bitumen is the viscoelastic fluid binding the crushed stones and mineral aggregates in the asphalt material used to pave roads around the world. During the paving procedure, the volatile compounds are lost and oxidization occurs with variation of the mechanical characteristics (aging); thus, the ma... |
39949780 | cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values. | Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination and routine screening. The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytoso... |
39949739 | Homoharringtonine: mechanisms, clinical applications and research progress. | Homoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies in recent years. This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key roles in inducing apopt... |
39949351 | Profiling of small RNAs derived from tomato brown rugose fruit virus in infected <i>Solanum lycopersicum</i> plants by deep sequencing. | Tomato brown rugose fruit virus (ToBRFV) is an emerging, rapidly spreading virus belonging to the genus <i>Tobamovirus</i> which seriously decreases tomato yields. RNA silencing is an evolutionarily conserved antiviral mechanism. In virus-infected plants, virus-derived small interfering RNAs (vsiRNAs) are one of the ke... |
39943161 | An Insight into Differentially Expressed Genes and MicroRNAs in the Pituitary Glands of the Two Estrous Phases of Sheep with Different <i>FecB</i> Genotypes. | As an important class of non-coding RNAs, miRNAs participate in a variety of biological processes, including cell proliferation, differentiation, apoptosis, and hormone secretion. However, little is known about the role of pituitary miRNAs in follicular development in <i>FecB</i> mutant (Fecundity Booroola) sheep. Give... |
39942719 | Molecular Modification of Queen Bee Acid and 10-Hydroxydecanoic Acid with Specific Tripeptides: Rational Design, Organic Synthesis, and Assessment for Prohealing and Antimicrobial Hydrogel Properties. | Royal jelly and medical grade honey are traditionally used in treating wounds and infections, although their effectiveness is often variable and insufficient. To overcome their limitations, we created novel amphiphiles by modifying the main reparative and antimicrobial components, queen bee acid (hda) and 10-hydroxyl-d... |
39942720 | Understanding Intrinsic Electrochemical Properties of NiCo-Metal-Organic Framework-Derived NiCo<sub>2</sub>O<sub>4</sub> as a Li-Ion Battery Anode. | This study explores the electrochemical properties of additive-free NiCo₂O₄ derived from NiCo-metal-organic frameworks (MOFs) as a high-performance anode material for lithium-ion batteries (LIBs), excluding the effect of additives. NiCo-MOF was synthesized via an ultrasonic-assisted method and deposited on stainless st... |
39942295 | Preparation and Study of Physicochemical and Adsorption Properties of Alginate Composites. | This paper presents the preparation and study of the properties of alginate materials, which were obtained on the basis of sodium alginate, activated carbon, cellulose, and calcium chloride. Alginate-carbon (AlgCa + C) and alginate-cellulose (AlgCa + Cel) composites, as well as pure calcium alginate (AlgCa) for compara... |
39940989 | The Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Review. | Alzheimer's disease (AD) is one of the most common and severe forms of dementia and neurodegenerative disease. As life expectancy increases in line with developments in medicine, the elderly population is projected to increase in the next few decades; therefore, an increase in the prevalence of some diseases, such as A... |
39940994 | <i>TSLP</i> and <i>TSLPR</i> Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps. | TSLP is an alarmin released upon activation of epithelia in response to various external stimuli and is involved in type 2 cytokine-mediated pathological disorders. The formation of a high-affinity heterodimeric receptor complex, comprising the thymic stromal lymphopoietin receptor (TSLPR) chain and IL-7Rα, is required... |
39940981 | Fluence Rate-Dependent Kinetics of Light-Triggered Liposomal Doxorubicin Assessed by Quantitative Fluorescence-Based Endoscopic Probe. | Liposomal doxorubicin (Dox), a treatment option for recurrent ovarian cancer, often suffers from suboptimal biodistribution and efficacy, which might be addressed with precision drug delivery systems. Here, we introduce a catheter-based endoscopic probe designed for multispectral, quantitative monitoring of light-trigg... |
39940979 | Leveraging Cholesterol-Functionalized Cyclodextrin Nanosponges for Enhanced Drug Delivery in Cancer Cells. | Cholesterol, the essential building block of cellular membranes, has proven to be a useful tool for increasing the biocompatibility and bioavailability of drug delivery systems in cancer treatment. Resveratrol, a natural polyphenolic compound with promising anticancer properties, faces significant limitations due to it... |
39940971 | Hybrid Lanthanide Metal-Organic Compounds with Flavonoids: Magneto-Optical Properties and Biological Activity Profiles. | Lanthanides have seen rapid growth in the pharmaceutical and biomedical field, thus necessitating the development of hybrid metal-organic materials capable of exerting defined biological activities. Ternary hybrid lanthanide compounds were synthesized through reaction systems of Ln(III) (Ln = La, Nd, Eu) involving the ... |
39940966 | Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers. | Depositions of protein aggregates are typical pathological hallmarks of various neurodegenerative diseases (NDs). For example, amyloid-beta (Aβ) and tau aggregates are present in the brain and plasma of patients with Alzheimer's disease (AD); α-synuclein in Parkinson's disease (PD), dementia with Lewy bodies (DLB), and... |
39940957 | Design and Expression of <i>Fasciola hepatica</i> Multiepitope Constructs Using mRNA Vaccine Technology. | <i>Fasciola hepatica</i> is a parasitic trematode responsible for fascioliasis, a significant zoonotic disease affecting livestock worldwide, as well as humans. This study identifies peptides with potential for use in vaccines against <i>Fasciola hepatica</i> and validates multi-epitope constructs from those peptides i... |
39940575 | Epoxy-Based Vitrimers for Sustainable Infrastructure: Emphasizing Recycling and Self-Healing Properties. | Epoxy-based vitrimers represent a paradigm shift in material science, offering an unprecedented combination of mechanical robustness, environmental sustainability, and reconfigurability. These dynamic polymer systems utilize associative dynamic covalent bonds (DCBs) such as transesterification to blend the structural i... |
39940200 | Comparison of Single Atoms vs. Sub-Nanoclusters as Co-Catalysts in Perovskites and Metal Oxides for Photocatalytic Technologies. | Adatoms as co-catalysts may play a key role in photocatalysis, yet control of their exact configuration remains challenging. Specifically, there is converging evidence that ultra-small structures may be optimal as co-catalysts; however, a comprehensive distinction between single atoms (SAs), sub-nanoclusters (SNCs), an... |
39919325 | Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN. | PTEN is an important tumor suppressor protein that is regulated by ubiquitination events which are modulated by deubiquitinases, or enzymes that remove ubiquitin from substrate proteins. As ubiquitinated substrates are beneficial to study deubiquitinase activity and substrate recognition, we have previously developed a... |
39914328 | The nonanol/surfactant directed self-assembly supramoleculars heat-shrinkable tubing liquid phase microextraction for determination of flavonoids in natural products combined with high performance liquid chromatography. | In this paper, a supramolecular heat-shrinkable tubing liquid phase microextraction was developed for the enrichment and determination of flavonoids. The nonanol adsorbed by the heat-shrinkable tubing could induce the surfactant in aqueous solution to self-assembly on its surface, and formed nonanol/CTAB supramolecules... |
39914195 | Tight orchestration of wound healing phase through metal-organic compounds. | Cutaneous wound healing remains a common health problem. Metal-organic frameworks (MOFs) have emerged as an advanced therapeutic platform for promoted wound healing. However, there is a lack of MOF particles possessing excellent stability, biocompatibility, and reactive oxygen species (ROS) scavenging ability for tight... |
39907072 | Polymorphism in a secondary phosphine. | Two crystal structures of bis(2,3,5,6-tetramethylphenyl)phosphine, C<sub>20</sub>H<sub>27</sub>P, are reported constituting the first recorded case of polymorphism in a secondary phosphine (R<sub>2</sub>PH). The two structures differ in their conformation and, as a result, the steric hindrance experienced at the phosph... |
39899941 | Computational investigation of graphyne monolayer as a promising carrier for anticancer drug delivery. | The study employs density functional theory (DFT) to examine the drug-loading efficiency of graphyne (GYN) as a vehicle for the Tioguanine (TG) drug. The researchers analyzed the interaction energy, electrical properties of pure GYN, TG molecules, and TG@GYN complex to determine their effectiveness as a carrier. Config... |
39898282 | Unlocking a radioactive pertechnetate (TcO<sub>4</sub> <sup>-</sup>) treatment process with functionalized metal-organic frameworks (MOFs). | Technetium-99 (<sup>99</sup>Tc), a troublesome radioisotope prevalent in nuclear liquid waste, poses significant environmental and human health hazards due to its long half-life, high fission yield, and fast environmental mobility. The successful mitigation of <sup>99</sup>Tc is imperative for nuclear waste management;... |
39896883 | From phytomedicine to conventional drug research, to look for new drug molecule against monkey pox virus; a molecular docking, virtual screening and ADME analysis. | Globally, traditional and complementary therapies (such as homeopathy, phytotherapy and herbal medications) are becoming increasingly prevalent alongside modern medical care. The therapeutic substances used in homeopathy and other traditional complementary medicine disciplines are derived from these traditional applica... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.