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39916886 | Molecular Aharonov-Bohm-type interferometers based on porphyrin nanorings. | A goal of molecular electronics and spintronics is to create molecular devices that change their conductance in response to external stimuli. The Aharonov-Bohm (AB) effect implies that an electronic device formed from a quantum ring and metallic leads will exhibit such behavior under external magnetic fields. At first ... |
39911332 | Distal C-H functionalization of alkoxyarenes through organic photoredox-catalyzed radical-radical coupling. | We developed a distal C-H functionalization of electron-rich arenes such as alkoxyarenes using diverse coupling partners through organic photoredox catalysis. Our reaction features radical-radical coupling between a cyclohexadienyl radical and various persistent radicals. A range of functional groups, including sp<sup>... |
39908975 | Surface-enhanced Raman spectroscopy (SERS)-based urine biopsy for kidney transplant patients. | For kidney transplantation patients, monitoring potential complications such as immune rejection and infection has always been a clinical challenge since the existing detection technology faces difficulties due to limited information, insufficient sensitivity and specificity, and lack of continuous dynamic monitoring a... |
39896851 | Intercalated MOF nanocomposites: robust, fluorine-free and waterborne amphiphobic coatings. | Transparent non-wetting surfaces with mechanical robustness are critical for applications such as contamination prevention, (anti-)condensation, anti-icing, anti-biofouling, <i>etc.</i> The surface treatments in these applications often use hazardous per- and polyfluoroalkyl substances (PFAS), which are bio-persistent ... |
39896097 | Admission Blood Glucose Level with a Cutoff Value of 15 mmol/L Is a Reliable Predictor of Mortality in Polytraumatized Patients-a Prospective, Observational, Longitudinal Study From a North African Level One Trauma Center. | <h4>Background</h4>Abnormal admission blood glucose levels were proved to have a mortality predictive value in polytraumatized patients, as reported by studies in developed countries. Reports from developing countries are scarce.<h4>Objective</h4>To evaluate the reliability of on-admission blood glucose levels in predi... |
39895981 | Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment. | <h4>Background</h4>Osteoarthritis (OA), a prevalent joint disease, causes immense suffering to thousands of patients, impairing their mobility and diminishing their quality of life. Current treatment methods primarily rely on analgesics or anti-inflammatory drugs to alleviate symptoms but fail to achieve the desired th... |
39895450 | Effect of the Membrane Environment on Pharmacologic Inhibition of hERG K<sup>+</sup> Channel Activity. | <h4>Background</h4>hERG encodes K<sub>V</sub>11.1 voltage-gated K<sup>+</sup> channels, which generate the rapidly activating delayed rectifier K<sup>+</sup> current that contributes to repolarization of the cardiac action potential. In addition to being targeted by many class III antiarrhythmic agents, these channels ... |
39893728 | Enhanced stability and separation resolution of gas chromatographic stationary phases via nano-MIL-103 fabrication. | The development of stable and high-performance stationary phases is essential for achieving high-resolution gas chromatographic (GC) isomer separation. This study demonstrated a simple and effective method for synthesizing a stable nano metal-organic framework (MOF) as an efficient stationary phase for GC separation. T... |
39890072 | Supramolecular self-assembly of high-loaded horseradish peroxidase and biorecognized antibody into Au/polydopamine nanocomposites for sensitive immunoassay of Escherichia coli O157:H7 in milk. | There is an urgent need for a rapid and sensitive method for the detection of Escherichia coli O157:H7, a class of hazardous foodborne pathogens in food safety. The traditional ELISA, a dominant rapid detection technique, has the disadvantage of low test sensitivity due to the insufficient enzyme loading capacity. In t... |
39889915 | Are balance and lower extremity muscle strength correlated with fracture risk independent of bone mineral density in postmenopausal women?: A cross-sectional study. | <h4>Background</h4>Postmenopausal women are at increased risk of fractures due to reduced bone mineral density (BMD) and impaired physical function. While fracture risk assessment tools like FRAX include clinical factors and BMD, they exclude functional measures such as balance and muscle strength, which are critical f... |
39888174 | Unlocking Peak Efficiency in Anion-Exchange Membrane Electrolysis with Iridium-Infused Ni/Ni<sub>2</sub>P Heterojunction Electrocatalysts. | Developing cost-effective, highly efficient, and durable bifunctional electrocatalysts for water electrolysis remains a significant challenge. Nickel-based materials have shown promise as catalysts, but their efficiency in alkaline electrolytes is still lacking. Fascinatingly, Mott-Schottky catalysts can fine-tune elec... |
39888158 | Synergy of Pyridinic-N and Co Single Atom Sites for Enhanced Oxygen Redox Reactions in High-Performance Zinc-Air Batteries. | Cobalt single-atom catalysts (SACs) have the potential to act as bi-functional electrocatalysts for the oxygen-redox reactions in metal-air batteries. However, achieving both high performance and stability in these SACs has been challenging. Here, a novel and facile synthesis method is used to create cobalt-doped-nitro... |
39887940 | Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3-O-UGT2. | Ginsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting of ginseng aglycone attached to various glycans. Pq3-O-UGT2, an important UDP-dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside Rg3 and Rd by extending the glycan chain of Ginsenoside Rh2 and F2, ... |
39887795 | Light-Emitting Diodes Based on Metal Halide Perovskite and Perovskite Related Nanocrystals. | Light-emitting diodes (LEDs) based on halide perovskite nanocrystals have attracted extensive attention due to their considerable luminescence efficiency, wide color gamut, high color purity, and facile material synthesis. Since the first demonstration of LEDs based on MAPbBr<sub>3</sub> nanocrystals was reported in 20... |
39886102 | Improving outcomes with early and intensive metabolic control in patients with type 2 diabetes: a long-term modeling analysis of clinical and cost outcomes in Italy. | <h4>Objectives</h4>This analysis quantifies the potential long-term clinical and cost benefits of early and intensive metabolic control (EIMC) versus conventional management in patients newly diagnosed with type 2 diabetes in Italy.<h4>Methods</h4>The PRIME T2D Model was used to project clinical and cost outcomes over ... |
39884121 | An electrochemical nano-genosensor for SARS-CoV-2 detection utilizing Ce-metal organic framework, dendritic palladium nano-structure, and sulfur-doped graphene oxide. | The emergence of COVID-19 has underscored an urgent demand to develop an innovative, rapid, and reliable diagnostic tool for early detection of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Biosensors present a viable alternative, offering reliability, precision, and cost efficiency that address the... |
39882189 | Preparedness, prevention and control related to zoonotic avian influenza. | A risk assessment framework was developed to evaluate the zoonotic potential of avian influenza (AI), focusing on virus mutations linked to phenotypic traits related to mammalian adaptation identified in the literature. Virus sequences were screened for the presence of these mutations and their geographical, temporal a... |
39882187 | Coordinated One Health investigation and management of outbreaks in humans and animals caused by zoonotic avian influenza viruses. | When investigating and controlling outbreaks caused by zoonotic avian influenza viruses (AIV), a One Health approach is key. However, knowledge-sharing on AIV-specific One Health strategies, tools and action plans remains limited across the EU/EEA. It is crucial to establish responsibilities, capacity requirements, and... |
39882009 | DNA dendrimer-based nanocarriers for targeted Co-delivery and controlled release of multiple chemotherapeutic drugs. | DNA-based nanomaterials have attracted increasing attention over the past decades due to their incomparable programmability and functionality. In particular, dendritic DNA nanostructures are ideal for constructing drug carriers due to their highly branched structure. In this study, an intelligent drug delivery system w... |
39882005 | A scalable and eco-friendly carbohydrate-based oleogelator for vitamin E controlled delivery. | Supramolecular oleogels, in which low-molecular weight oleogelators self-assemble into various nanostructures through non-covalent interactions, have witnessed increasing research activity in various fields of science, including food, cosmetics or remediation of marine oil spills. Herein, we report a simple scalable an... |
39882004 | Selenium-based nanomaterials: green and conventional synthesis methods, applications, and advances in dye degradation. | The rapidly expanding industrialization and global increase in economic activities have drawn attention to the concerning accumulation of waste. The textile industry plays a significant role in environmental pollution, especially in and water pollution. Harmful dyes used during the fabrication process are mixed with wa... |
39882000 | Novel mixed matrix membranes with indium-based 2D and 3D MOFs as fillers and polysulfone for CO<sub>2</sub>/CH<sub>4</sub> mixed gas separation. | To address the limitations of polymeric membranes, mixed matrix membranes for CO<sub>2</sub> separation from biogas mixtures (CO<sub>2</sub> and CH<sub>4</sub>) have been investigated utilizing various fillers. In this study, we investigated novel MMMs using 3D and 2D indium-based MOFs, MIL-68(In)-NH<sub>2</sub> and In... |
39881787 | A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization-explanation of its folded conformation. | Chronic myeloid leukaemia (CML) is primarily treated using imatinib mesylate, a tyrosine kinase inhibitor (TKI) targeting the BCR::ABL1 oncoprotein. However, the development of drug resistance and adverse side effects necessitate the exploration of alternative therapeutic agents. This study presents the synthesis and c... |
39881370 | Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an innovative green and high throughput microwell assay for analysis of bulk form and pharmaceutical formulation. | For paediatric patients suffering from neurofibromatosis, Selumetinib (SEL) is the only approved drug. Here an original ecofriendly and high pace method is introduced using 96- microwell spectrophotometric assay (MW-SPA) to measure SEL content in bulk and commercial pharmaceutical formulation (Koselugo<sup>®</sup> caps... |
39881355 | From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges. | Acute pancreatitis (AP) is a disease characterized by an acute inflammatory response in the pancreas. This is caused by the abnormal activation of pancreatic enzymes by a variety of etiologic factors, which results in a localized inflammatory response. The symptoms of this disease include abdominal pain, nausea and vom... |
39881346 | Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing. | The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production of endogenous nitric oxide (NO) due to the hyperglycemic microenvironment typic... |
39881297 | Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? | Extracellular membrane vesicles (EVs) offer promising values in various medical fields, e.g., as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in tissue engineering, regenerative medicine and cancer therapy. Based on their cellular origin EVs can vary considerably in composition ... |
39881185 | Impact of choline choride and sugar natural deep eutectic solvents on structure and functionality of treebean (Parkia timoriana) seed protein. | This study explores the impact of natural deep eutectic solvents (NADES) on the structure and functionality of treebean (Parkia timoriana) seed protein, a novel approach to enhancing protein stability and functionality for sustainable bioprocessing. The research aims to evaluate the dynamic interactions between protein... |
39881117 | Solid state NMR spectral editing of histidine, arginine and lysine using Hadamard encoding. | The NMR signals from protein sidechains are rich in information about intra- and inter-molecular interactions, but their detection can be complicated due to spectral overlap as well as conformational and hydrogen exchange. In this work, we demonstrate a protocol for multi-dimensional solid-state NMR spectral editing of... |
39881093 | Ultrasensitive and selective impedance paper-based analytical device through Dual-C imprinted sensor for determination of carcinoembryonic antigen and C-reactive protein. | Carcinoembryonic antigen (CEA) and C-reactive protein (CRP) are biomacromolecules known as cancer and inflammatory markers. Thus, they play a crucial role in early cancer diagnosis, post-treatment recurrence detection, and tumor risk assessment. This paper describes the development of an ultrasensitive and selective im... |
39880971 | Confinement-induced Ni-based MOF formed on Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene support for enhanced capacitive deionization of chromium(VI). | MXenes, as a novel two-dimensional lamellar material, has attracted much attention. However, MXenes lamellar are prone to collapse and stacking under hydrogen bonding and interlayer van der Waals forces, which affects their electrochemical and capacitive deionization performance. A three-dimensional Ni-1,3,5-benzenetri... |
39880944 | Copper-dependent halogenase catalyses unactivated C-H bond functionalization. | Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp<sup>3</sup>)-H bond<sup>1-3</sup>. In recent years, metalloenzymes have been found to perform C(sp<sup>3</sup>)-H ... |
39880863 | Microbe-assisted fabrication of circularly polarized luminescent bacterial cellulosic hybrids. | The fabrications of circularly polarized luminescent (CPL) material are mainly based on the chemical and physical strategies. Controlled biosynthesis of CPL-active materials is beset with difficulties due to the lack of bioactive luminescent precursors and bio-reactors. Enlighted by microbe-assisted asymmetric biosynth... |
39880831 | Elucidating the potential of EGFR mutated NSCLC and identifying its multitargeted inhibitors. | Lung cancer is the leading cause of cancer-related fatalities globally, accounting for the highest mortality rate among both men and women. Mutations in the epidermal growth factor receptor (EGFR) gene are frequently found in non-small cell lung cancer (NSCLC). Since curcumin and CB[2]UN support various medicinal appli... |
39880822 | The ENaC taste receptor's perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis. | The ENaC receptor acts as a taste receptor to recognize and perceive salty substances. This study explored the mechanisms by which the ENaC taste receptor recognizes and binds mushroom-derived salty peptides using molecular interaction and molecular simulation. The three subunits α, β, and γ of the ENaC taste receptor ... |
39880813 | The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake. | The mycobacterial ABC transporter IrtAB features an ABC exporter fold, yet it imports iron-charged siderophores called mycobactins. Here, we present extensive cryo-EM analyses and DEER measurements, revealing that IrtAB alternates between an inward-facing and an outward-occluded conformation, but does not sample an out... |
39880388 | Hyaluronic Acid-Coated SPIONs with Attached Folic Acid as Potential T2 MRI Contrasts for Anticancer Therapies. | Superparamagnetic iron oxide nanoparticles (SPIONs) are known to be good MRI contrasts, but they have a high tendency to aggregate and their biocompatibility is limited. Hyaluronic acid is highly biocompatible, can provide SPION with colloidal stability, and interacts specifically with tumor cells through the CD44 rece... |
39879530 | Dual Pathways of Photorelease Carbon Monoxide via Photosensitization for Tumor Treatment. | Carbon monoxide (CO) gas therapy, as an emerging therapeutic strategy, is promising in tumor treatment. However, the development of a red or near-infrared light-driven efficient CO release strategy is still challenging due to the limited physicochemical characteristics of the photoactivated carbon monoxide-releasing mo... |
39879378 | New PPARα Agonist A190-Loaded Microemulsion for Chemotherapy-Induced Peripheral Neuropathy. | Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of anticancer agents with limited effective preventive or therapeutic interventions. Although fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, has demonstrated neuroprotective and analgesic properties, its clinica... |
39879313 | A phytoplasma effector suppresses insect melanization immune response to promote pathogen persistent transmission. | Insect melanization triggered by the conversion of prophenoloxidase to active phenoloxidase via serine proteases (SPs) is an important immediate immune response. However, how phytoplasmas evade this immune response to promote their propagation in insect vectors remains unknown. Here, we demonstrate that infection of le... |
39879308 | SnRK2 kinases sense molecular crowding and form condensates to disrupt ABI1 inhibition. | Plants sense and respond to hyperosmotic stress via quick activation of sucrose nonfermenting 1-related protein kinase 2 (SnRK2). Under unstressed conditions, the protein phosphatase type 2C (PP2C) in clade A interact with and inhibit SnRK2s in subgroup III, which are released from the PP2C inhibition via pyrabactin re... |
39879286 | Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment. | Tissue-specific endothelial cells (ECs) are critical for the homeostasis of pancreatic islets and most other tissues. In vitro recapitulation of islet biology and therapeutic islet transplantation both require adequate vascularization, which remains a challenge. Using human reprogrammed vascular ECs (R-VECs), human isl... |
39879104 | Rhodium-Catalyzed Homogeneous Asymmetric Hydrogenation of Naphthol Derivatives. | Due to their strong aromaticity and difficulties in chemo-, regio-, and enantioselectivity control, asymmetric hydrogenation of naphthol derivatives to 1,2,3,4-tetrahydronaphthols has remained a long-standing challenge. Herein, we report the first example of homogeneous asymmetric hydrogenation of naphthol derivatives ... |
39879096 | Computational Methods for Modeling Lipid-Mediated Active Pharmaceutical Ingredient Delivery. | Lipid-mediated delivery of active pharmaceutical ingredients (API) opened new possibilities in advanced therapies. By encapsulating an API into a lipid nanocarrier (LNC), one can safely deliver APIs not soluble in water, those with otherwise strong adverse effects, or very fragile ones such as nucleic acids. However, f... |
39879081 | The Quantum Information Science Challenge for Chemistry. | We discuss the goals and the need for quantum information science (QIS) in chemistry. It is important to identify concretely how QIS matters to chemistry, and we articulate some of the most pressing and interesting research questions at the interface between chemistry and QIS, that is, "chemistry-centric" research ques... |
39879074 | How Do the Valency and Radii of Cations Affect the Rheological Properties of Aqueous Solutions of Zwitterionic and Anionic Surfactant Mixtures? | Despite extensive research on the use of salts to enhance micellar growth, numerous questions remain regarding the impact of ionic exchange and molecular structure on charge neutralization. This study looks into how certain cations (Na<sup>+</sup>, Ca<sup>2+</sup>, and Mg<sup>2+</sup>) affect the structure of a cocamid... |
39878813 | Gold nanocomposites in colorectal cancer therapy: characterization, selective cytotoxicity, and migration inhibition. | The third most prevalent type of cancer in the world, colorectal cancer, poses a significant treatment challenge due to the nonspecific distribution, low efficacy, and high systemic toxicity associated with chemotherapy. To overcome these limitations, a targeted drug delivery system with a high cytotoxicity against can... |
39878762 | Protonolysis and Condensation Reactions of Alkoxido-Substituted Lindqvist {MW<sub>5</sub>} and Keggin {MPW<sub>11</sub>} Polyoxometalates: Comparative Experimental and Modeling Studies. | An understanding of proton transfer and migration at the surfaces of solid metal oxides and related molecular polyoxometalates (POMs) and metal alkoxides is crucial for the development of reactivity involving protonation or the absorption/binding of water. In this work, the hydrolysis of alkoxido Ti- and Sn-substituted... |
39878774 | Ph<sub>3</sub>AsO as a Strong Hydrogen-Bond Acceptor in Cocrystals with Hydrogen Peroxide and <i>gem-</i>Dihydroperoxides. | Hydrogen-bonded cocrystals have attracted considerable attention as they allow fine-tuning of properties through the choice of hydrogen-bond donors and acceptors. In this study, triphenylarsine oxide (Ph<sub>3</sub>AsO) is introduced as a strong hydrogen-bond acceptor molecule. Due to its higher Lewis basicity compared... |
39878692 | Enantiomer-Dependent Supramolecular Antibacterial Therapy for Drug-Resistant Bacterial Keratitis. | Bacteria have the potential to exhibit divergent stereochemical preferences for different levels of chiral structures, including from molecule, supramolecule, to nanomicroscale helical structure. Accordingly, the structure-activity relationship between chirality and bactericidal activity remains uncertain. In this stud... |
39878544 | A quality-by-design approach to develop abemaciclib solid lipid nanoparticles for targeting breast cancer cell lines. | <h4>Aim</h4>Abemaciclib (ABE) is an anticancer drug that suffers from low bioavailability and multidrug resistance. This study aims to develop ABE-loaded solid lipid nanoparticles (ABE-SLNs), which will enhance drug solubility and lead to increased cellular uptake and enhanced cytotoxicity when delivering tumor cells.<... |
39878538 | Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria. | The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration of alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactiv... |
39878523 | Current views and trends of nanomaterials as vectors for gene delivery since the 21st century: a bibliometric analysis. | <h4>Background</h4>Gene therapy is garnering increasing support due to its potential for a "once-delivered, lifelong benefit." The limitations of traditional gene delivery methods have spurred the advancement of bionanomaterials. Despite this progress, a thorough analysis of the evolution, current state, key contributo... |
39878506 | The photochemical inheritance of Eduardo Lissi and Juan Grotewold and the intersystem crossings with other inheritances. | In 1963, Eduardo Lissi and Juan Grotewold started a chemical kinetics and photochemistry group at the School of Sciences at the University of Buenos Aires (Facultad de Ciencias Exactas y Naturales, FCEN, UBA). Political circumstances in Argentina and in Chile were a great determinant of the evolution, dispersion, and r... |
39878509 | Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions. | During infection, bacterial pathogens rely on secreted virulence factors to manipulate the host cell. However, in gram-positive bacteria, the molecular mechanisms underlying the folding and activity of these virulence factors after membrane translocation are not clear. Here, we solved the protein structures of two secr... |
39878489 | Spermidine enhances the heat tolerance of <i>Ganoderma lucidum</i> by promoting mitochondrial respiration driven by fatty acid β-oxidation. | High temperature is an unavoidable environmental stress that generally exerts detrimental effects on organisms and has widespread effects on metabolism. Spermidine is an important member of the polyamines family and is involved in a range of abiotic stress responses in plants. Mitochondria play an essential role in cel... |
39878471 | A comprehensive review of current insights into the virulence factors of SARS-CoV-2. | The evolution of SARS-CoV-2 pathogenicity has been a major focus of attention. However, the determinants of pathogenicity are still unclear. Various hypotheses have attempted to elucidate the mechanisms underlying the evolution of viral pathogenicity, but a definitive conclusion has yet to be reached. Here, we review t... |
39878336 | Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy. | Single particle profiling (SPP) is a unique methodology to study nanoscale bioparticles such as liposomes, lipid nanoparticles, extracellular vesicles, and lipoproteins in a single particle and high throughput manner. The initial version requires the single photon counting modules for data acquisition, which limits its... |
39878198 | Identical Fe-N<sub>4</sub> Sites with Different Reactivity: Elucidating the Effect of Support Curvature. | Detailed atomic-scale understanding is a crucial prerequisite for rational design of next-generation single-atom catalysts (SACs). However, the sub-ångström precision needed for systematic studies is challenging to achieve on common SACs. Here, we present a two-dimensional (2D) metal-organic system featuring Fe-N<sub>4... |
39877963 | Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT. | Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at the target site to catalyze the production of reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy of PDT depends on the PSs, the amount of oxygen, and the intensity of the exc... |
39876837 | Single-Step Ethylene Purification and MTO Product Separation in a Nitrogen-Rich Microporous Metal-Organic Framework. | The nitrogen-rich metal-organic framework (MOF) <b>NTUniv-75</b>, featuring a melamine (MA) functional group, enables efficient one-step C<sub>2</sub>H<sub>4</sub> purification and methanol-to-olefins (MTO) product separation. At 298 K, its adsorption capacity follows the order C<sub>2</sub>H<sub>2</sub> > C<sub>3</sub... |
39876701 | Top-Down Strategy Enabling Elastic Wood Nanocarbon Sponges with Wrinkled Multilayer Structure and High Compressive Strength for High-Performance Compressible Supercapacitors. | 3D porous carbon electrodes have attracted significant attention for advancing compressible supercapacitors (SCs) in flexible electronics. The micro- and nanoscale architecture critically influences the mechanical and electrochemical performance of these electrodes. However, achieving a balance between high compressive... |
39875466 | Metal-organic frameworks-derived CaO/ZnO composites as stable catalysts for biodiesel production from soybean oil at room temperature. | Biodiesel presents a sustainable alternative to fossil fuels, yet traditional homogeneous catalysts like sodium and potassium hydroxide face challenges with separation and reuse. Calcium oxide (CaO) is an effective heterogeneous catalyst for biodiesel production, but its chemical instability under reaction conditions r... |
39875099 | Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks. | Epithelia are multicellular sheets that form barriers defining the internal and external environments. The constant stresses acting at this interface require that epithelial sheets are mechanically robust and provide a selective barrier to the hostile exterior. These properties are mediated by cellular junctions which ... |
39829281 | The Role of Open-Shell Organic Radical in Enhancing Anti-Tumor Photocatalysis Reaction of NIR Light-Activated Photosensitizer. | Open-shell radical materials, which are characterized by unpaired electrons, have led to revolutionary breakthroughs in material science due to their unique optoelectronic properties. However, the involvement of organic radicals in photodynamic therapy (PDT) has rarely been reported or discussed. This work studies two ... |
39823239 | A Hybrid BN-Doped Nanographene with Narrow Emission Bandwidths for OLEDs. | We describe synthesis of BN-doped nanographene containing five phenylene units, boron and nitrogen atoms with alternating ortho-disposition, as well as direct B-N connections. Resulting BN doped nanographene exhibits blue fluorescence at 441 nm with an extraordinarily narrow fluorescence peak with a full width at half ... |
39817527 | Oligoethylene Phosphoramidate-Based Kinase Inhibitor Prodrugs - Solubility, Enzyme Inhibition, and Hydrolysis. | The efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave off the PEG after reaching the target is important to make use of the therapeutic effects of the native drug. Mo... |
39807030 | Hierarchical structures of surface-accessible plasmonic gold and silver nanoparticles for SERS detection. | Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical technique with excellent molecular specificity. However, separate pristine nanoparticles produce relatively weak Raman signals. It is necessary to focus on increasing the "hot-spot" density generated at the nanogaps between the adjacent nanopar... |
39804208 | Viedma deracemization mechanisms in self-assembly processes. | Simulations on an ODE-based model shows that there are many common points between Viedma deracemization and chiral self-assemblies of achiral building blocks towards chiral nanoparticles. Both systems occur in a closed system with energy exchange but no matter exchange with the surroundings and show parallel reversible... |
39801447 | Role of polymer graft stiffness in electrostatic-driven self-assembly of nanoparticles in solutions. | Self-assembly of nanoparticles (NPs) in solution has garnered tremendous attention among researchers because of their electrical, chemical, and optoelectronic properties at the macroscale with potential applications in bio-imaging, bio-medicine, and therapeutics. Control of size, shape, and composition at the nanoscale... |
39749635 | Hydrogen-bonded multi-mode liquid crystal elastomer actuators. | As biomimicry advances, liquid crystal elastomers (LCEs) are gaining attention for their (multi-)stimuli-responsiveness and reversible shape morphing. Introduction of dynamic bonds into the LCEs provides versatile means towards programmable shape morphing and adaptation to environmental cues, and new designs for dynami... |
39746803 | Dorsomedial Striatum (DMS) CB1R Signaling Promotes Pavlovian Devaluation Sensitivity in Male Long Evans Rats and Reduces DMS Inhibitory Synaptic Transmission in Both Sexes. | Cannabinoid receptor-1 (CB1R) signaling in the dorsal striatum regulates the shift from flexible to habitual behavior in instrumental outcome devaluation. Based on prior work establishing individual-, sex-, and experience-dependent differences in pavlovian behaviors, we predicted a role for dorsomedial striatum (DMS) C... |
39745479 | Unravelling the influence of structure on the optical properties of a pair of aza-BODIPY isomers and their application in photodynamic therapy. | A pair of aza-BODIPY isomers, 1,7-di-<i>tert</i>-butyl-3,5-dinaphthyl (Nap-BDP) and 1,7-dinaphthyl-3,5-di-<i>tert</i>-butyl (revNap-BDP), were prepared in this study. According to the single crystal X-ray analysis, Nap-BDP exhibited an orthogonal structure. Owing to the difference in orthogonality and -<i>t</i>Bu rotat... |
39745373 | Double network hydrogels encapsulating genetically modified dedifferentiated chondrocytes for auricular cartilage regeneration. | Microtia profoundly affects patients' appearance and psychological well-being. Tissue engineering ear cartilage scaffolds have emerged as the most promising solution for ear reconstruction. However, constructing tissue engineering ear cartilage scaffolds requires multiple passaging of chondrocytes, resulting in their d... |
39745316 | Emerging biosensing platforms based on metal-organic frameworks (MOFs) for detection of exosomes as diagnostic cancer biomarkers: case study for the role of the MOFs. | Exosomes, which are considered nanoscale extracellular vesicles (EVs), are secreted by various cell types and widely distributed in different biological fluids. They consist of multifarious bioactive molecules and use systematic circulation for their transfer to adjoining cells. This phenomenon enables exosomes to take... |
39744991 | Multifunctional NO supramolecular nanomedicine for thrombus risk reduction and intimal hyperplasia inhibition. | Cardiovascular diseases (CVDs) are the foremost cause of mortality worldwide, with incidence and mortality rates persistently climbing despite extensive research efforts. Innovative therapeutic approaches are still needed to extend patients' lives and preserve their health. In the present study, novel supramolecular na... |
39714378 | The Biarylitides: Understanding the Structure and Biosynthesis of a Fascinating Class of Cytochrome P450 Modified RiPP Natural Products. | The biarylitides are a recently discovered class of RiPP natural products that are fascinating both from the small size of the core peptides as well as the diversity of peptide crosslinking exhibited by the cytochrome P450 enzymes found in these systems. In this review, we address the discovery and biosynthetic diversi... |
39714335 | Advances in peptide/polymer antimicrobial assemblies. | Antimicrobial peptides (AMPs) have been extensively exploited as promising drugs to cope with antibiotic-resistant bacteria in clinical treatment. Peptide/polymer assembly provides a particularly important contribution to this topic and has emerged as a new paradigm for the development of nano-antimicrobial systems wit... |
39714134 | A step towards non-invasive diagnosis of diabetes mellitus using <i>in situ</i> synthesized MOF-MXene hybrid material with extended gate field-effect transistor integration. | The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF-MXene (Ni<sub>BDC-MXene</sub>) hybrid mat... |
39699006 | Conservation of structure and dynamic behavior in triazine macrocycles with opportunities for subtle control of hinge motion. | Modifying the backbone of 24-atom macrocycles allows tailoring of physical properties (octanol-water partition coefficients, log <i>P</i>) while conserving both conformation and the barrier to dynamic, hinge-like motion. Structure is determined by 1D and 2D NMR spectroscopy. The barrier can be subtly tuned by modificat... |
40698174 | Protein profile of the Escherichia coli strain, BW25113, exposed to two novel iron-halide compounds: Fe(Hampy)2Cl4 and Fe(Hampy)2Br4. | The mortality rate and economic burden of infections caused by antimicrobial-resistant pathogens are increasingly higher. This frustrating scenario emphasizes the urgent need for developing new antimicrobial drugs. We have previously addressed this problem by studying the antimicrobial activity of two novel iron-halide... |
40666043 | ENT-1-Targeted Polymersomes to Enhance the Efficacy of Methotrexate in Choriocarcinoma Treatment. | Gestational choriocarcinoma (CC) is a rare and highly malignant cancer originating from the trophoblastic layers of the placenta. Currently, methotrexate (MTX) is the first-line treatment for CC; however, due to the aggressive and metastatic nature of CC, multiple doses are often required, leading to severe side effect... |
40657196 | Biodegradable Piezoelectric Micro- and Nanomaterials for Regenerative Medicine, Targeted Therapy, and Microrobotics. | Piezoelectric micro- and nanomaterials can generate local electrical signals when subjected to mechanical stress, a phenomenon that can be exploited to trigger beneficial effects at the cell and tissue level. In recent years, research on biodegradable piezoelectric material has gained momentum, as these materials can d... |
40395354 | Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel-Based Brain-Machine Interface Probes. | The mechanical mismatch between microelectrode of brain-machine interfaces (BMIs) and soft brain tissue during electrophysiological investigations leads to inflammation, glial scarring, and compromising performance. Herein, a nanostructured, stimuli-responsive, conductive, and semi-interpenetrating polymer network hydr... |
40124089 | Osteogenic differentiation of mesenchymal stem cells in cell-laden culture of self-assembling peptide hydrogels. | Mesenchymal stem cell (MSC) osteogenic differentiation requires scaffolds to support multiple stages of growth and differentiation signals. Fluorenyl-9-methoxycarbonyl diphenylalanine (Fmoc-FF) peptides self-assemble to create 3D nanofibers. Here, we cultured MSC in 2D and 3D Fmoc-FF layers to support their osteogenic ... |
40018678 | Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity. | Interleukin (IL)-18 is an immunoregulatory cytokine that acts as a potent inducer of T helper 1 and cytotoxic responses. IL-18 activity is regulated by its decoy receptor IL-18 binding protein (IL-18BP) which forms a high affinity complex with IL-18 to block binding of the cognate receptors. A disbalance between IL-18 ... |
40006539 | Formulation and Evaluation of Polymeric Spherical Agglomerates-Based Porous Orodispersible Tablets of Cilnidipine. | <b>Background/Objectives:</b> Cilnidipine (CIL) is a calcium channel blocker that exhibits low bioavailability (~13%) due to poor aqueous solubility and extensive pre-systemic gut wall metabolism. The current study aimed to enhance the oral bioavailability of CIL by formulation of polymeric spherical agglomerates (CILS... |
40003601 | Exploring Marine Natural Compounds: Innovative Therapeutic Candidates Against Chagas Disease Through Virtual Screening and Molecular Dynamics. | Chagas disease, caused by the protozoan <i>Trypanosoma cruzi</i>, represents a significant public health challenge, particularly in Latin America's endemic regions. The limited efficacy and frequent adverse effects of current treatments underscore the need for novel therapeutic options. This research explores marine na... |
39997328 | The Development and Application of Bispecific Antibodies in B-Cell Non-Hodgkin Lymphoma. | T-cell-engaging bispecific antibodies (BsAbs) are monoclonal antibodies that redirect the cytotoxic activity of T-cells to target malignant neoplasms. B-cell non-Hodgkin lymphoma (B-NHL) is a heterogenous group of aggressive and indolent malignancies with significant therapeutic challenges due to high relapse rates and... |
39997105 | Design and Development of Natural-Product-Derived Nanoassemblies and Their Interactions with Alpha Synuclein. | Biomimetic nanoassemblies derived from natural products are considered promising nanomaterials due to their self-assembling ability and their favorable interactions with biological molecules leading to their numerous applications as therapeutic agents or as molecular probes. In this work, we have created peptide nanoco... |
39995443 | The multidrug-resistant <i>Candida auris, Candida haemulonii</i> complex and phylogenetic related species: Insights into antifungal resistance mechanisms. | The rise of multidrug-resistant (MDR) fungal pathogens poses a serious global threat to human health. Of particular concern are <i>Candida auris</i>, the <i>Candida haemulonii</i> complex (which includes C<i>. haemulonii sensu stricto, C. duobushaemulonii</i> and <i>C. haemulonii</i> var. <i>vulnera</i>), and phylogene... |
39978909 | Nano Sim@ZIF8@PDA modified injectable temperature sensitive nanocomposite hydrogel for photothermal/drug therapy for peri-implantitis. | Dental implant restoration has become one of the most important treatments for missing teeth. However, peri-implantitis is a common complication of implant restorations, and lack of timely and effective treatment will most likely lead to implant failure. Here, we developed a chitosan-based multifunctional temperature-s... |
39974818 | Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition. | The present study aimed to synthesize metal-doped magnesium oxide (MgO) nanoparticles to drastically reduce polydispersity and stabilize them with generation 5 of poly(amidoamine) (G5 PAMAM) dendrimers to assess their antidiabetic properties via controlled release. Zinc and silver metals were selected as dopants due to... |
39974650 | Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response in a Mouse Model of Depression. | In this preclinical pilot study, we used [<sup>11</sup>C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. PET imaging was performed in a validated mouse model of depression/anxiety (CORT model), and the effect of 5-week treatment with fluoxetine was tested. Depression/anxiety phe... |
39968149 | Deep sequencing of serially passaged Sudan virus in guinea pigs uncovers adaptive mutations. | Orthoebolaviruses are non-segmented, negative sense RNA viruses that make up the genus <i>Orthoebolavirus</i> in the family <i>Filoviridae</i>. Sudan virus (SUDV) is a highly pathogenic orthoebolavirus that causes severe disease in humans. In the last 45 years, SUDV has been responsible for several outbreaks in eastern... |
39967829 | Microvascular endothelial cells display organ-specific responses to extracellular matrix stiffness. | The extracellular matrix was originally thought of as simply a cellular scaffold but is now considered a key regulator of cell function and phenotype from which cells can derive biochemical and mechanical stimuli. Age-associated changes in matrix composition drive increases in matrix stiffness. Enhanced matrix stiffnes... |
39959102 | Efficient and Explainable Virtual Screening of Molecules through Fingerprint-Generating Networks Integrated with Artificial Neural Networks. | A machine learning-based drug screening technique has been developed and optimized using a novel, stitched neural network architecture with trainable, graph convolution-based fingerprints as a base into an artificial neural network. The architecture is efficient, explainable, and performant as a tool for the binary cla... |
39959078 | Host-Guest Dynamic Behavior of Melatonin Encapsulated in β-Cyclodextrin Nanosponges. | Cyclodextrin-based nanosponges are cross-linked polymeric porous nanomaterials obtained by condensation of cyclodextrins with a polyfunctional reagent (cross-linker). Owing to their high surface area, they are attractive for encapsulation applications aimed at increasing the stability, solubility, and bioavailability o... |
39959081 | Structural, CSD, Molecular Docking, Molecular Dynamics, and Hirshfeld Surface Analysis of a New Mesogen, Methyl-4-(5-(4-(octyloxy)phenyl)-1,2,4-oxadiazol-3-yl)benzoate. | 1,2,4-Oxadiazoles are well recognized for their exceptional physical, chemical, and pharmacokinetic properties, making them promising candidates for various therapeutic applications. These include treatments for cystic fibrosis, Duchenne muscular dystrophy, Alzheimer's disease, and a broad spectrum of other therapeutic... |
39959064 | Biobased Food Packaging Systems Functionalized with Essential Oil via Pickering Emulsion: Advantages, Challenges, and Current Applications. | The development of innovative active food packaging is a promising strategy to mitigate food loss and waste while enhancing food safety, extending shelf life, and maintaining overall quality. In this review, Pickering emulsions with essential oils are critically evaluated as active additives for sustainable food packag... |
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