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39896217 | The JN.1 variant of COVID-19: immune evasion, transmissibility, and implications for global health. | The emergence of the COVID-19 JN.1 variant has raised global health concerns as it gains prevalence in several regions worldwide. First identified in August 2023, JN.1 evolved from the Omicron lineage's BA.2.86 subvariant. Patients infected with JN.1 commonly exhibit symptoms such as sore throat, fever, dry cough, naus... |
39892666 | Imipenem/cilastatin encapsulation in UIO-66-NH<sub>2</sub> carrier as a new strategy for combating imipenem-resistant Pseudomonas aeruginosa isolates. | <h4>Background</h4>This study aims to investigate the effectiveness of UIO-66-NH<sub>2</sub>, a metal-organic framework, as a carrier for imipenem/cilastatin (Imp/Cil) in overcoming resistance in clinical isolates of imipenem-resistant Pseudomonas aeruginosa.<h4>Methods</h4>The UIO-66-NH<sub>2</sub>-Imp/Cil formulation... |
39892547 | Boronic acid functionalized hierarchical covalent organic frameworks based on sacrificial template and thiol-ene click chemistry for the enhanced enrichment of glycoproteins. | Glycoproteins are closely related to the formation and development of many diseases and even cancer, it is necessary to design and develop a method for efficient isolation and enrichment of glycoproteins in biomedical sciences, and in particular biomarker research. In this work, a strategy has been developed for the sy... |
39883380 | The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases. | Some of the most crucial turning points in the treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with the introduction of antimicrobials and vaccines. Drug resistance and poor effectiveness are key limitations that need to be overcome. Conventional liposomes have... |
39883285 | Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment. | Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer ca... |
39883276 | Growth trajectory of Yiling sheep and its related genetic parameters. | Growth traits are one of the focuses of sheep breeding, and growth curve is an effective method to describe growth traits. The body weight of Yiling sheep at 0, 120, 180, 360 and 540 days of age were fitted with five common nonlinear growth models: Logistic, Gompertz, Von Bertalanffy, Brody and Negative exponential, an... |
39883101 | Understanding Anionic Hyperporphyrins: TDDFT Calculations on Peripherally Deprotonated <i>meso</i>-Tetrakis(4-hydroxyphenyl)porphyrin. | Presented herein is a DFT/TDDFT study of <i>meso</i>-tetrakis(4-hydroxyphenyl)porphyrin (H<sub>2</sub>[THPP]) and its <i>O</i>-deprotonated tetraanionic form; the latter was modeled as both a free tetraanion and with various counterions. Based on our calculations, the experimentally observed hyperporphyrin spectra are ... |
39889305 | Expanding the tagging toolbox for visualizing translation live. | Translation is a highly regulated process that includes three steps: initiation, elongation, and termination. Tremendous efforts have been spent to study the regulation of each translation step. In the last two decades, researchers have begun to investigate translation by tracking it in its native and live intracellula... |
39888276 | Peptide-Bound Aflibercept Eye Drops for Treatment of Neovascular Age-Related Macular Degeneration in Nonhuman Primates. | The advent of biomacromolecules antagonizing vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (nAMD). However, frequent intravitreal injections of these biomacromolecules impose an enormous burden on patients and create a massive workload for hea... |
39888252 | Muco-Penetrating Lipid Nanoparticles Having a Liquid Core for Enhanced Intranasal mRNA Delivery. | Intranasal delivery of mRNA vaccines offers promising opportunities to combat airborne viruses like SARS-CoV-2 by provoking mucosal immunity, which not only defends against respiratory infection but also prevents contagious transmission. However, the development of nasal mRNA vaccines has been hampered by the lack of e... |
39888152 | Inhalable Nano Formulation of Cabazitaxel: A Comparative Study with Intravenous Route. | Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, the pulmonary (INH) route is the other choice for inhalable formulations. In the study, biochemical and histological parameters of Cabazitaxel (CBZ) f... |
39887942 | Nanotherapies Based on ROS Regulation in Oral Diseases. | Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modul... |
39887941 | Supramolecular Modulation of Tumor Microenvironment Through Host-Guest Recognition and Metal Coordination to Potentiate Cancer Chemoimmunotherapy. | The massive amount of indoleamine 2,3-dioxygenase 1 (IDO-1) in tumor cells and tumor-associated immune cells forms a feedback loop that maintains immunosuppressive tumor microenvironment (ITM) and causes immune escape, resulting in the poor prognosis of platinum chemotherapeutics. However, the effective systemic admini... |
39887904 | Free Volume Space of Polymers as a New Functional Nanospace: Synthesis of Guest Polymers. | Nanospace has been used as a specific field for syntheses and assemblies of molecules, polymers, and materials. Free volume space among polymer chains is related to their properties, such as permeation of gas and small molecules. However, the void has not been used as a functional nanospace in previous works. The prese... |
39887820 | Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function. | <h4>Introduction</h4>Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be a potential therapeutic strategy for AD. Our ... |
39887671 | Photothermal-Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy. | Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease, presenting a challenge for targeted treatment. Traditional topical ocular drug delivery methods often fail to effectively reach the meibomian glands (MGs). To address this, the study has developed a soluble microneedles (MN) patch comp... |
39887654 | Structural Basis and Mechanism of a Unique Haemophore in the Haem-Iron Acquisition by Riemerella anatipestifer. | Several bacterial pathogens employ haemophores to scavenge haem from host haemoprotein to obtain an iron source. However, no homologues of well-characterized haemophores are found in Riemerella anatipestifer, a bacterium belonging to the order Flavobacteriales that encodes haem uptake systems. Herein, a unique haemopho... |
39887601 | Microneedles at the Forefront of Next Generation Theranostics. | Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devic... |
39885706 | Pyridinamide Ion Pairs: Design Principles for Super-Nucleophiles in Apolar Organic Solvents. | A comprehensive analytical protocol combining conductivity, diffusion-ordered NMR (DOSY), and photometric kinetic measurements is employed to analyze the nucleophilic reactivity of pyridinamide ion pairs in low-polarity organic solvents. The association patterns of these systems are found to strongly depend on cation s... |
39885648 | Propionylation of Fis K32 in <i>Salmonella enterica</i> serovar Typhi: a key modification affecting pathogenicity. | <h4>Aim</h4>This study aims to explore the role of propionylation at the K32 residue of the global regulator Fis in <i>Salmonella enterica</i> serovar Typhi (<i>S</i>. Typhi) and its influence on the pathogenicity of the bacteria.<h4>Materials & methods</h4>Bacterial strains were cultured in media with sodium propionat... |
39885614 | Targeting RNA splicing modulation: new perspectives for anticancer strategy? | The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors. Therefore, identifying ... |
39885557 | Radioresistance in rectal cancer: can nanoparticles turn the tide? | Rectal cancer accounts for over 35% of the worldwide colorectal cancer burden representing a distinctive subset of cancers from those arising in the colon. Colorectal cancers exhibit a continuum of traits that differ with their location in the large intestine. Due to anatomical and molecular differences, rectal cancer ... |
39885494 | CCDC154 knockdown inhibits growth of liver cancer via suppressing expression of Snail. | <h4>Objective</h4>The effect of coiled-coil domain-containing 154 (CCDC154) in liver cancer (LC) remains unexplored. The objective of this study was to investigate the role of CCDC154 in LC and its underlying mechanism.<h4>Methods</h4>The analysis of CCDC154 expression and prognosis was performed using UALCAN, Human Pr... |
39885392 | Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer. | <h4>Background</h4>Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated molecular mechanisms... |
39885362 | Peripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze-thaw process. | While silk fibroin (SF) obtained from silkworm cocoons is expected to become a next-generation natural polymer, a fabrication method for SF-based artificial nerve conduits (SFCs) has not yet been established. Here, we report a bioresorbable SFC, fabricated using a novel freeze-thaw process, which ensures biosafety by a... |
39885306 | Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1. | Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DEN... |
39885296 | Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade. | Previously, we demonstrated that natural host-defence peptide caerin 1.1/caerin 1.9 (F1/F3) increases the efficacy of anti-PD-1 and therapeutic vaccine, in a HPV16 + TC-1 tumour model, but the anti-tumor mechanism of F1/F3 is still unclear. In this study, we explored the impact of F1/F3 on the tumor microenvironment in... |
39885295 | Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma. | Multiple myeloma (MM) remains an incurable hematological malignancy that necessitates the identification of novel therapeutic strategies. Here, we report that intracellular levels of very long chain fatty acids (VLCFAs) control the cytotoxicity of MM chemotherapeutic agents. Inhibition of VLCFA biosynthesis reduced cel... |
39885293 | PIF/harbinger transposon-derived protein promotes 7SL expression to enhance pathogen resistance. | Transcriptional regulation governs gene expression levels, primarily controlled by "cis-acting DNA elements" and "trans-acting protein factors". However, the conventional view that cis-regulation is solely attributable to DNA elements is challenged in this study. Our research indicates that transposon-derived proteins ... |
39885251 | Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer. | Sympathetic nerves regulate nearly all human organs. Their peripheral nerves are present in tumor tissue. Activation of the sympathetic nervous system promotes malignant transformation in several cancers. This study aimed to quantify sympathetic nerve density (SND) in gastric cancer and investigate the relationship bet... |
39885205 | TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway. | In this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition. Specifically, we focus on the spontaneous ability of cells to bypass or override this checkpoint, referred to as checkpoint adaptation.... |
39885130 | Phase separation of a microtubule plus-end tracking protein into a fluid fractal network. | Microtubule plus-end tracking proteins (+TIPs) participate in nearly all microtubule-based cellular processes and have recently been proposed to function as liquid condensates. However, their formation and internal organization remain poorly understood. Here, we have study the phase separation of Bik1, a CLIP-170 famil... |
39885129 | Site-specific substitution in atomically precise carboranethiol-protected nanoclusters and concomitant changes in electronic properties. | We report the synthesis of [Ag<sub>17</sub>(o<sub>1</sub>-CBT)<sub>12</sub>]<sup>3-</sup> abbreviated as Ag<sub>17</sub>, a stable 8e⁻ anionic cluster with a unique Ag@Ag<sub>12</sub>@Ag<sub>4</sub> core-shell structure, where o<sub>1</sub>-CBT is ortho-carborane-1-thiol. By substituting Ag atoms with Au and/or Cu at s... |
39885068 | MOF UiO-66 and its composites: design strategies and applications in drug and antibiotic removal. | Antibiotics and pharmaceuticals exert significant environmental risks to aquatic ecosystems and human health. Many effective remedies to this problem have been developed through research. Metal-organic frameworks (MOFs) are potential constituents, for drug and antibiotic removal. This article explores the potential of ... |
39885015 | Genome-wide identification of carboxyesterase family members reveals the function of GeCXE9 in the catabolism of parishin A in Gastrodia elata. | <h4>Key message</h4>GeCXE9 can catalyze the hydrolysis of parishin A via two pathways during the medicinal processing of Gastrodia elata. Gastrodia elata Bl. is used in traditional Chinese medicine for its bioactive compounds, particularly phenols. The molecular mechanisms of phenols formation and regulation remain to ... |
39884955 | Copper-Mediated Enantioselective C-H Thiolation of Ferrocenes Enabled by the BINOL Ligand. | Transition-metal-catalyzed enantioselective C-H activation has transformed the landscape of asymmetric synthesis, enabling the efficient conversion of C-H bonds into C-C and carbon-heteroatom (C-X) bonds. However, the formation of C-S bonds through enantioselective C-H thiolation remains underdeveloped due to challenge... |
39884678 | Antagonistic Effects of Distance and Overlap toward Anomalous Pressure-Induced Blueshift of π-π Excimer Fluorescence in 9-(2,2-Diphenylvinyl)anthracene Crystals. | Piezochromic materials usually exhibit a gradual redshift of emission as pressure increases due to the formation of a low-energy "dark" state, e.g., excimer. However, our study presents an anomalous excimer-based pressure-induced emission blueshift. A crystal was investigated here with a discrete π-π anthracene dimer s... |
39883886 | Regioselective [3 + 2] Annulation of β,γ-Alkynyl-α-ketimino Esters with 1,3-Dicarbonyls: The Synthesis of Highly Functionalized Dihydrofurans. | A regioselective [3 + 2] annulation of β,γ-alkynyl-α-ketimino esters with 1,3-dicarbonyls is disclosed. A series of <i>Z</i>-selective dihydrofurans bearing an exocyclic double bond and a quaternary carbon center are accessed without the usage of base. Control and deuterium-labeling experiments have been investigated t... |
39883874 | Sonodynamic Therapy by Reactive Oxygen Species Generation-Responsive Pseudo-Semiconducting Polymer Nanoparticles Combined with a Fibroblast Growth Factor Receptor Inhibitor for Enhancing Immunotherapy in Bladder Cancer. | Sonodynamic therapy, a treatment modality recently widely used, is capable of disrupting the tumor microenvironment by inducing immunogenic cell death (ICD) and enhancing antitumor immunity during immunotherapy. Erdafitinib, an inhibitor of the fibroblast growth factor receptor, has demonstrated potential benefits for ... |
39883858 | Biomimetic Silk Nanoparticle Manufacture: Calcium Ion-Mediated Assembly. | Silk has emerged as an interesting candidate among protein-based nanocarriers due to its favorable properties, including biocompatibility and a broad spectrum of processing options to tune particle critical quality attributes. The silk protein conformation during storage in the middle silk gland of the silkworm is modu... |
39883598 | Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. | Virulent microbes produce proteins that interact with host cell targets to promote pathogenesis. For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. To detect and respond to the activities of effectors, diverse phyla of host organisms evo... |
39883033 | Beyond Surfactants: Janus Particles for Functional Interfaces and Coatings. | Janus particles (JPs), initially introduced as soft matter, have evolved into a distinctive class of materials that set them apart from traditional surfactants, dispersants, and block copolymers. This mini-review examines the similarities and differences between JPs and their molecular counterparts to elucidate the uni... |
39883031 | Quantitative MALDI-TOF Mass Spectrometry of Star-Shaped Polylactides Based on Chromatographic Hyphenation. | The end groups of three- and four-arm star-shaped polylactides (PLA) with trimethylolpropane and pentaerythritol core structures were functionalized with acetic acid. Reaction products with different degrees of functionalization were analyzed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mas... |
39883007 | High-Throughput Quantification and Characterization of Dual Payload mRNA/LNP Cargo via Deformulating Size Exclusion and Ion Pairing Reversed Phase Assays. | Therapeutic drugs and multivalent vaccines based on the delivery of mRNA via lipid nanoparticle (LNP) technologies are expected to dominate the biopharmaceutical industry landscape in the coming years. Many of these innovative therapies include several nucleic acid components (e.g., nuclease mRNA and guide RNA) posing ... |
39882987 | Self-Assembly of Mycolic Acid in Water: Monolayer or Bilayer. | The enduring pathogenicity of <i>Mycobacterium tuberculosis</i> can be attributed to its lipid-rich cell wall, with mycolic acids (MAs) being a significant constituent. Different MAs' fluidity and structural adaptability within the bacterial cell envelope significantly influence their physicochemical properties, operat... |
39882957 | Using Machine Learning to Design a FeMOF Bidirectional Regulator for Electrochemiluminescence Sensing of Tau Protein. | The single-luminophore-based ratiometric electrochemiluminescence (ECL) sensor coupling bidirectional regulator has become a research hotspot in the detection field because of its simplicity and accuracy. However, the limited bidirectional regulator hinders its further development. In this study, by leveraging the robu... |
39882873 | A Supramolecular Fluorescent Chemosensor Enabling Specific and Rapid Quantification of Norepinephrine Dynamics. | Host-guest supramolecular fluorescence probes have garnered significant attention in the detection and sensing of bioactive molecules due to their functionalization potential, adjustable physical properties, and high specificity. However, such probes that reliably, rapidly, and specifically measure neurotransmitter dyn... |
39882866 | Screening of Aluminum-Based MOFs for Effective In Situ Immobilization of Biomolecules. | An effective approach for the immobilization and protection of biological entities is their encapsulation via the in situ synthesis of metal-organic frameworks (MOFs). To ensure the preservation of the bioentities, mild synthetic conditions, including aqueous media and ambient conditions (temperature and pressure), are... |
39882860 | Assessing the threat of <i>Yersinia pestis</i> harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC. | Self-transmissible IncC plasmids rapidly spread multidrug resistance in many medically important pathogens worldwide. A large plasmid of this type (pIP1202, ~80 Kb) has been isolated in a clinical isolate of <i>Yersinia pestis</i>, the agent of plague. Here, we report that pIP1202 was highly stable in <i>Y. pestis-</i>... |
39882804 | Ru(II)-Based Multitopic Hosts for Fullerene Binding: Impact of the Anion in the Recognition Process. | The development of multitopic hosts for fullerene recognition based on nonplanar corannulene (C<sub>20</sub>H<sub>10</sub>) structures presents challenges, primarily due to the requirement for synergistic interactions with multiple units of this polycyclic aromatic hydrocarbon. Moreover, increasing the number of corann... |
39882781 | Neoantigen mRNA vaccines and A<sub>2</sub>A receptor antagonism: A strategy to enhance T cell immunity. | Although neo-antigen mRNA vaccines are promising for personalized cancer therapy, their effectiveness is often limited by the immunosuppressive tumor microenvironment (TME). The adenosine A<sub>2</sub>A receptor (A<sub>2</sub>AR) inhibits dendritic cell (DC) function and weakens antitumor T cell responses through hypox... |
39882766 | Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, <i>in vitro</i> activity and computational studies. | <h4>Background</h4>Due to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.<h4>Methods</h4>Five Schiff base ligands and their complexes were synthesized, char... |
39882743 | Recent advances in fluorescent gold nanocluster-based bioanalytical analysis and imaging in living cell. | Ultrasmall and highly fluorescent gold nanoclusters (Au NCs) have been widely used for the construction of sensing and imaging platforms. Specifically, through a combination of surface functionalization and spectral analysis and/or imaging techniques, effective intracellular detection and imaging are realized. In this ... |
39882727 | Chemospecific Heterostructure and Heteromaterial Assembly of Metal-Organic Framework Nanoparticles. | Nanoparticles of highly porous metal-organic frameworks (MOFs) are some of the most exciting nanomaterials under development, with potential applications that range from biomedicine and catalysis to adsorption technologies. However, our synthetic methodologies to functionalize and manipulate MOF nanoparticles (NPs) are... |
39882669 | Macroscopic Gold Cluster Helical Tendrils. | Handedness-controllable macroscopic helices are needed for understanding the chirality transfer through scales and design of high-performance devices. Bottom-up self-assembly rarely affords macroscopic helical superstructures because of accumulating disorder that is difficult to avoid during hierarchical self-assembly.... |
39882662 | Sub-5 nm Silicon Nanopore Sensors: Scalable Fabrication via Self-Limiting Metal-Assisted Chemical Etching. | Solid-state nanopores offer unique possibilities for biomolecule sensing; however, scalable production of sub-5 nm pores with precise diameter control remains a manufacturing challenge. In this work, we developed a scalable method to fabricate sub-5 nm nanopores in silicon (Si) nanomembranes through metal-assisted chem... |
39881633 | Morphology-Transport Coupling and Dissipative Structures in PEO-PS+LiTFSI Electrolytes In-Operando Conditions. | A Single-Chain-in-Mean-Field (SCMF) algorithm was introduced to study block copolymer electrolytes in nonequilibrium conditions. This method self-consistently combines a particle-based description of the polymer with a generalized diffusion equation for the ionic fluxes, thus exploiting the time scale separation betwee... |
39866086 | Open Rotaxane Surgery: What Molecular Editing Can Offer to Supramolecular Chemistry? | The skeletal editing approach represents a paradigm shift in organic synthesis by directly targeting the molecular skeleton instead of relying on often long and complicated series of organic transformations. Recent advancements in nitrogen atom deletion reactions have enabled unprecedented late-stage, precise modificat... |
39864631 | PSMA-targeted delivery of docetaxel in prostate cancer using small-sized PDA-based micellar nanovectors. | In this study, we present the first comparative analysis of active and passive drug delivery systems for docetaxel (DTX) in prostate cancer using supramolecular self-assembled micellar nanovectors. Specifically, we developed two novel micelles based on polydiacetylenic amphiphiles (PDA) for passive and active targeting... |
39817640 | Effect of the Electrolyte on the Oxygen Reduction Reaction with a MOF Embedded Co-Porphyrin. | Electrocatalysis in metal-organic frameworks is an interplay between the diffusion of charges, the intrinsic catalytic rate, and the mass-transport of reactants through the pores. Here a systematic study is carried out to investigate the role of the electrolyte nature and concentration on the oxygen reduction reaction ... |
39813070 | Can conformational flexibility influence the self-assembly behavior and sensing efficacy of fluorogenic amphiphiles? A case study with bisbenzimidazole-based probes. | In this work, we have explored the metal ion sensing properties of two bisbenzimidazole-based fluorescent probes, that differ in their conformational flexibility, in an aqueous medium. The compound with a flexible methyl spacer (1) experienced blue shifts in its absorption and emission maxima (along with a turn-off res... |
39804574 | The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance. | The Stenotrophomonas maltophilia L2 cephalosporinase is one of two beta-lactamases that afford S. maltophilia beta-lactam resistance. With the overuse of beta-lactams, selective pressures have contributed to the evolution of these proteins, generating proteins with an extended spectrum of activity. Variant L2 cephalosp... |
39803875 | A metal-organic framework with mixed electron donor and electron acceptor ligands for efficient lithium-ion storage. | Electron donor tetrathiafulvalene (TTF) and electron acceptor naphthalene diimide (NDI) derivatives were used to synthesize a 3D Zn-TTF/NDI-MOF. Multiple redox active sites and charge transfer endow the pristine MOF anode with excellent rate behavior and long term cycling performance (with an average specific capacity ... |
39787708 | Gold nanocages co-assembled with<i>Spinacia oleracea</i>extract combined photothermal/photodynamic therapy in 4T1 breast cancer cell line. | Photothermal therapy (PTT) and photodynamic therapy (PDT) have been emerging as potential alternatives to conventional cancer treatment modalities. Gold nanoparticles, owing to their surface plasmon resonance properties, have been promising in cancer phototherapies, and extracts from potent medicinal plants are commonl... |
39758013 | Encapsulation of biomimetic nanozymes in MOF matrices as peroxidase mimetics for sensitive detection of L-cysteine. | A metal-organic framework (MOF)-encapsulated nanozyme has been developed to detect L-cysteine (L-Cys) through a facile colorimetric sensing method in this study. This nanozyme was prepared by encapsulating Fmoc-histidine (FH) and hemin within ZIF-8 (FH/hemin@ZIF-8) and exhibited significantly enhanced catalytic activit... |
39749677 | Research on a molecularly imprinted electrochemical sensor based on a graphene quantum dot-gold nanoparticle composite for the determination of 17β-estradiol. | In this study, a molecularly imprinted electrochemical sensor (MIECS) was constructed based on the combination of graphene quantum dots-gold nanoparticles (GQDs-AuNPs), molecular imprinting polymer (MIP), and electrochemical technology for the ultra-sensitive detection of 17β-estradiol (E<sub>2</sub>). GQDs-AuNPs were ... |
39036934 | Neuroimaging in the diagnosis and treatment of cerebral toxoplasmosis in children with severe β-thalassemia after allo-HSCT. | Children with severe β-thalassemia major (β-TM) are at high risk of developing toxoplasmosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study was to identify the neuroimaging findings of cerebral toxoplasmosis in pediatric patients with β-TM for early diagnosis and treatment o... |
40306854 | Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling. | Strategic delivery of hydrogels to the newly formed myocardial infarction (MI) is an area of active investigation and offers high target specificity for releasing a small molecule therapeutic payload. This study examined the effects of delayed post-MI delivery (pigs, 3 days post-MI) of a shear-thinning hydrogel which e... |
40047593 | Unlocking the Potential of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene: Present Trends and Future Developments of Gas Sensing. | In recent years, the need for future developments in sensor technology has arisen out of the changing landscape, such as pollution monitoring, industrial safety, and healthcare. MXenes, a 2D class of transition metal carbides, nitrides, and carbonitrides, have emerged as a particularly promising group in part due to th... |
40028061 | [<sup>45</sup>Ti]Ti-HOPOs: Potential Complexes for the Development of <sup>45</sup>Ti PET Imaging Agents. | Titanium-45 (<sup>45</sup>Ti) is a radionuclide with desirable physical characteristics for use in positron emission tomography (PET) imaging including a moderate half-life (3.08 h), decay by positron emission (85%), and low mean positron energy of 0.439 MeV. Despite these promising characteristics, the radiochemistry ... |
40027884 | <i>In vivo</i> production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection. | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants repeatedly evade the immune system within short periods. Thus, next-generation therapeutics that are resistant to mutations and can be rapidly supplied to individuals in an emergency are required. Here, we designed an mRNA encoding an engineered angi... |
40017770 | DNA Nanotechnology in the Undergraduate Laboratory: Toehold-Less Strand Displacement in Switchback DNA. | Dynamic DNA nanostructures that reconfigure into different shapes are used in several applications in biosensing, drug delivery, and data storage. One of the ways to produce such structural transformations is by a process called strand displacement. This laboratory experiment demonstrates a strand displacement reaction... |
40015782 | "Off-on-off"-based metal-organic framework fluorescent sensor for adenosine triphosphate detection and tumor microenvironment-triggered drug release. | Extracellular adenosine triphosphate (ATP) and low extracellular pH are emerging targets for cancer treatment because they are crucial messengers shaping the tumor microenvironment (TME) and regulating tumor progression. Doxorubicin (Dox) is a common chemotherapeutic agent used against numerous solid tumors; however, i... |
40005997 | Andrographolide Sulfonates and Xiyanping: A Review of Chemical Composition, Pharmacological Activities, Clinical Applications, and Adverse Reactions. | <i>Andrographis paniculata</i> is a plant of the Acanthaceae family and its primary bioactive constituent, andrographolide, exhibits a broad spectrum of pharmacological activities and notable clinical efficacy. However, its poor solubility and limited bioavailability pose significant challenges for therapeutic applicat... |
40002347 | Effect of Photoperiod on Ascorbic Acid Metabolism Regulation and Accumulation in Rapeseed (<i>Brassica napus</i> L.) Seedlings. | Ascorbic acid (AsA) is an important antioxidant for human health. The concept of "oil-vegetable-duel-purpose" can significantly enhance the economic benefits of the rapeseed industry. Rapeseed, when utilized as a vegetable, serves as a valuable food source of AsA. In this study, we integrated transcriptome and metabolo... |
39996979 | Enzyme Biosensor Based on 3D-Printed Flow-Through Reactor Modified with Thiacalixarene-Functionalized Oligo (Lactic Acids). | Electrochemical enzyme biosensors are extensively utilized in clinical analysis and environmental monitoring, yet achieving effective enzyme immobilization while maintaining high activity remains a challenge. In this work, we developed a flow-through enzyme biosensor system using a 3D-printed flow-through electrochemic... |
39996639 | Hydrogels from Protein-Polymer Conjugates: A Pathway to Next-Generation Biomaterials. | Hybrid hydrogels from protein-polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein-polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These propert... |
39981035 | Quantifying hexafluoroisopropanol's hydrogen bond donor ability: infrared photodissociation spectroscopy of halide anion HFIP complexes. | We report on the gas phase vibrational spectroscopy (3500-950 cm<sup>-1</sup>) of halide anion complexes with 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and its partially deuterated analogue (HFIP-<i>d</i> <sub>1</sub>). Infrared photodissociation spectra of messenger-tagged X<sup>-</sup>(HFIP/HFIP-<i>d</i> <sub>1</sub>)... |
39974649 | Novel Soluble Epoxide Hydrolase Inhibitor: Toward Regulatory Preclinical Studies. | Neuroinflammation is widely recognized as a key pathological hallmark of Alzheimer's disease (AD). Recently, inhibiting soluble epoxide hydrolase (sEH) has emerged as a promising therapeutic strategy for AD. sEH plays a pivotal role in neuroinflammation by hydrolyzing epoxyeicosatrienoic acids (EETs), which have anti-i... |
39973975 | On the reversibility of amyloid fibril formation. | Amyloids are elongated supramolecular protein self-assemblies. Their formation is a non-covalent assembly process and as such is fully reversible. Amyloid formation is associated with several neurodegenerative diseases, and the reversibility is key to maintaining the healthy state. Reversibility is also key to the perf... |
39968523 | Natural collagen scaffold with intrinsic piezoelectricity for enhanced bone regeneration. | Materials-mediated piezoelectric signals have been widely applied in bone regeneration. Collagen is the most abundant protein in the human body, and native collagen with complete tertiary structure shows efficient piezoelectricity. However, the traditional collagen scaffolds are lack of piezoelectricity due to the dest... |
39963432 | Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology. | Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as a promising approach to enhance drug delivery across physiological barriers, particularly the blood-brain barrier (BBB) a... |
39950106 | Lignin- and Cellulose-Derived Sustainable Nanofiltration Polyelectrolyte Membranes. | Nanofiltration (NF) polymeric membranes are typically made from fossil fuel-derived feedstocks and toxic solvents, requiring a shift to more sustainable materials. This study pioneers the use of two biopolymers-cationic lignin and sodium carboxymethyl cellulose-as polycation and polyanion, respectively, to fabricate a ... |
39944946 | <i>In silico</i> characterisation of the avocado <i>WAK/WAKL</i> gene family with a focus on genes involved in defence against <i>Phytophthora cinnamomi</i>. | The avocado industry faces a significant threat from the hemibiotrophic oomycete pathogen <i>Phytophthora cinnamomi</i>. A variably expressed defence gene during an avocado infection trial was a <i>Wall-associated kinase</i> (<i>WAK</i>). WAK and WAK-Like (WAKL) proteins are known to bind to fragmented pectin (oligogal... |
39944835 | Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects. | Cancer is one of the most serious public health challenges in the world. The number of new and fatal patients with cancer continues to increase every year, which poses a serious threat to human health. Although there are effective treatments such as radiotherapy and chemotherapy for cancers, they are often accompanied ... |
39944688 | Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH. | Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B. Using purified plasma proteins and recombinant mutants, FHR-B was found to form dimers and bind stron... |
39944627 | Polymers for the treatment of Alzheimer's disease. | Alzheimer's disease (AD) is one of the most common diseases of the central nervous system in the middle-aged and elderly population. It is a neurodegenerative disorder, and its main clinical symptoms include the loss of established memories, a decline in learning capacity, and the buildup of β-amyloid peptides. The dis... |
39944624 | Advance in identified targets of berberine. | Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, including antibacterial... |
39944353 | Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer. | <h4>Objectives</h4>This study employs bibliometric analysis to track evolution and identify trends of key topics in ferroptosis within the context of lung cancer. By identifying emerging research areas, our aim is to provide valuable insights and directions for researchers in this field.<h4>Methods</h4>Relevant papers ... |
39943962 | Recent advances in the biosynthesis of polysaccharide-based antimicrobial glycoconjugate vaccines. | Glycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections. These vaccines are synthesized by covalently linking bacterial polysaccharide antigens to a carrier protein. Given that they produce a stro... |
39942703 | The Preparation of Cyclic Binary Block Polymer Using Bimolecular Homodifunctional Coupling Reaction and Characterization of Its Performance as a Drug Carrier. | There is relatively little research on cyclic amphiphilic block polymers, having both hydrophilic and hydrophobic segments placed in the ring and thus resulting in a higher degree of topological restriction, as drug vehicles. Cyclic amphiphilic binary block polymer is synthesized by the click coupling reaction of bimol... |
39942282 | Flexible Pressure Sensors Based on Polyvinylidene Fluoride: A Critical Review. | With the advent of the intelligent era, flexible piezoelectric tactile sensors, as key components for sensing information and transmitting signals, have received worldwide attention. However, piezoelectric pressure sensors are still currently limited, which severely restricts their practical applications. Furthermore, ... |
39942040 | Application of Smart Packaging in Fruit and Vegetable Preservation: A Review. | The application of smart packaging technology in fruit and vegetable preservation has shown significant potential with the ongoing advancement of science and technology. Smart packaging leverages advanced sensors, smart materials, and Internet of Things (IoT) technologies to monitor and regulate the storage environment... |
39941558 | Nanotechnology and Artificial Intelligence in Dyslipidemia Management-Cardiovascular Disease: Advances, Challenges, and Future Perspectives. | This narrative review explores emerging technologies in dyslipidemia management, focusing on nanotechnology and artificial intelligence (AI). It examines the current treatment recommendations and contrasts them with the future prospects enabled by these innovations. Nanotechnology shows significant potential in enhanci... |
39940948 | Comparison of Lysis and Amplification Methodologies for Optimal 16S rRNA Gene Profiling for Human and Mouse Microbiome Studies. | When conducting sequence-based analysis of microbiome samples, it is important to accurately represent the bacterial communities present. The aim of this study was to compare two commercially available DNA isolation and PCR amplification approaches to determine their impact on the taxonomic composition of microbiome sa... |
39940941 | Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice. | Progestogens' anti-anxiety and anti-depressive effects and mechanisms are not well-understood. Progestogens are hypothesized to have anti-anxiety and anti-depressive effects on behavior, independent of actions at nuclear progestin receptors (NPRs) and dependent on allopregnanolone (5α-pregnan-3α-ol-20-one; 3α,5α-THP), ... |
39940935 | Selective Catalysis by Complexes Including Ni and Redox-Inactive Alkali Metals (Li, Na, or K) in Oxidation Processes: The Role of Hydrogen Bonds and Supramolecular Structures. | It is known that the presence of redox-inactive metals in the active center of an enzyme has a significant effect on its activity. In this regard and for other reasons, the effect of redox-inactive metals on redox processes, such as electron transfer, oxygen and hydrogen atom transfer, as well as the breaking and forma... |
39940927 | <i>Cornus mas</i> L. Extracts Exhibit Neuroprotective Properties, Further Enhanced by Metal-Bound Energy-Linked Organic Substrates. | Neurodegenerative diseases have been increasingly plaguing the global population, with attempts to understand their etiopathogenesis and pursue therapeutics being at the forefront of multidisciplinary efforts. To that end, research was launched in our lab, based on natural products and bioessential metal ion complex fo... |
39940567 | Dipolar Brush Polymers: A Numerical Study of the Force Exerted onto a Penetrating Colloidal Particle Under an External Field. | Langevin Dynamics numerical simulations have been used to compute the force profiles that dipolar polymer brushes exert onto a penetrating colloidal particle. It has been observed that force profiles are strongly influenced by externally applied fields: at large distances from the grafting surface, a force barrier appe... |
39940566 | Carbon Nanodots-Based Polymer Nanocomposite: A Potential Drug Delivery Armament of Phytopharmaceuticals. | Carbon nanodots (CNDs) have garnered significant attention as viable drug delivery vehicles in recent years, especially in the field of phytomedicine. Although there is much promise for therapeutic applications with phytomedicine, its effectiveness is frequently restricted by its low solubility, stability, and bioavail... |
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