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39958819 | The future of plant lectinology: Advanced technologies and computational tools. | Lectins play crucial roles in many biological processes and serve as tools in fields ranging from agriculture to biomedicine. While classical methods for lectin discovery and characterization were foundational for the field, they often lack sensitivity and throughput, limiting the detection of less abundant or weakly b... |
39944791 | Gradient scaffolds in bone-soft tissue interface engineering: Structural characteristics, fabrication techniques, and emerging trends. | Bone and soft tissues are connected by a complex interface that is crucial for the smooth transfer of mechanical stress. Effective repair of this interface requires bio-scaffolds specifically designed to support the regeneration of diverse cell types and signalling molecules. With advances in micro- and nanotechnologie... |
39944407 | Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi <i>Alternaria alternata</i> BRN05 isolated from seeds of <i>Swietenia macrophylla</i> king. | There is a growing demand for new diabetes drugs with fewer side effects to replace current medications known for their adverse effects. Inhibition of α-glucosidase responsible for postprandial hyperglycemia among diabetes patients is a promising strategy for managing the disease. This study aims to explore and identif... |
39943418 | Integrating an Extended-Gate Field-Effect Transistor in Microfluidic Chips for Potentiometric Detection of Creatinine in Urine. | Monitoring creatinine levels in urine helps to recognize kidney dysfunction. In this research, we developed a photocurable membrane for the detection of serum creatinine. Using a system based on field-effect transistors, we carried out creatinine quantification in synthetic urine. The device was able to cover values be... |
39942694 | Three New Multifunctional Supramolecular Compounds Based on Keggin-Type Polyoxoanions and 3,5-di(1H-Imidazol-1-yl)benzoic Acid: Syntheses, Structures, and Properties. | Three new inorganic-organic hybrid compounds, (H<sub>3</sub>DIBA)<sub>2</sub>·SiMo<sub>12</sub>O<sub>40</sub>·H<sub>2</sub>O (<b>1</b>), (H<sub>3</sub>DIBA)<sub>2</sub>·SiW<sub>12</sub>O<sub>40</sub>·H<sub>2</sub>O (<b>2</b>), and [(H<sub>2</sub>DIBA)(H<sub>3</sub>DIBA)]·PMo<sub>12</sub>O<sub>40</sub>·2H<sub>2</sub>O (... |
39940909 | Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver. | Xenobiotics, including drugs, undergo metabolism to facilitate detoxification and excretion. Predicting a compound's metabolic fate before clinical trials is crucial for efficacy and safety. The existing methods rely on in vitro systems and in vivo animal testing. In vitro systems do not replicate the complexity of in ... |
39940555 | Assembling Carbon Nanotube and Graphene in Chitosan/Sodium Alginate Hydrogels for Ion Removal Applications. | Hydrogels have emerged as a promising material for the removal of heavy metal ions from contaminated water owing to their high water absorption capacity and biocompatibility. Despite notable advancements in improving the adsorptive capacity of hydrogels, the demand for a more efficient structure persists. Here, we expl... |
39940184 | Microporous Adsorbents for CH<sub>4</sub> Capture and Separation from Coalbed Methane with Low CH<sub>4</sub> Concentration: Review. | A rapid increase in natural gas consumption has resulted in a shortage of conventional natural gas resources, while an increasing concentration of CH<sub>4</sub> in the atmosphere has intensified the greenhouse effect. The exploration and utilization of coalbed methane (CBM) resources not only has the potential to fill... |
39936034 | Mechanisms and roles of membrane-anchored ATG8s. | Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion. However, recent studies have identified non-canonical roles for lipidated ATG8 in processes such as LC3-associated phagoc... |
39935800 | Mapping knowledge landscapes and emerging trends in artificial intelligence for antimicrobial resistance: bibliometric and visualization analysis. | <h4>Objective</h4>To systematically map the knowledge landscape and development trends in artificial intelligence (AI) applications for antimicrobial resistance (AMR) research through bibliometric analysis, providing evidence-based insights to guide future research directions and inform strategic decision-making in thi... |
39935788 | Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue. | <h4>Introduction</h4>This study explores the effects of moderate-intensity exercise on protein lactylation in mouse muscle tissue metabolism.<h4>Methods</h4>Healthy adult mice running for 6 weeks as an exercise model and sedentary mice as the control were used to perform transcriptomic, proteomic, lactylation-proteomic... |
39935787 | BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework. | Articular cartilage lines bones in synovial joints, and its main structural element, collagen, has an arcade-like arrangement formed from an initially random network in a process called postnatal maturation. This reshaping of the extracellular matrix is similar across all species and is critical for the lifelong streng... |
39935786 | Synthetic embryology of the human heart. | The evolution of stem cell-based heart models from cells and tissues to organoids and assembloids and recently synthetic embryology gastruloids, is poised to revolutionize our understanding of cardiac development, congenital to adult diseases, and patient customized therapies. Human induced pluripotent stem cell-derive... |
39935714 | Endothelial protease-activated receptor 4: impotent or important? | The protease thrombin, which increases its levels with various pathologies, can signal through the G protein-coupled receptors protease-activated receptors 1 and 4 (PAR1/PAR4). PAR1 is a high-affinity receptor for thrombin, whereas PAR4 is a low-affinity receptor. Finding functions for PAR4 in endothelial cells (ECs) h... |
39935687 | Dissection of the genetic basis and molecular mechanism of ovule number per ovary in oilseed rape (<i>Brassica napus</i> L.). | Ovule number per ovary (ONPO) determines the maximum potential of seed number per fruit that is a direct component of seed yield in crops. This study aimed to dissect the genetic basis and molecular mechanism of ONPO using a newly developed doubled haploid (DH) population in oilseed rape. In all the four investigated e... |
39935634 | The family <i>Thermoactinomycetaceae</i>: an emerging microbial resource with high application value. | In recent years, interest has increased in the use of microorganisms to obtain additional valuable resources for green and sustainable development. Preliminary functional analyses have indicated that members of the family <i>Thermoactinomycetaceae</i> have good application potential for the production of novel specific... |
39935532 | Estradiol metabolism by gut microbiota in women's depression pathogenesis: inspiration from nature. | The recurrence and treatment resistance of depression remain significant issues, primarily due to an inadequate understanding of its pathogenesis. Recent scientific evidence indicates that gut microbiota influence estradiol metabolism and are associated with the development of depression in nonpremenopausal women. Inte... |
39935480 | <i>In silico</i> design of a multi-epitope vaccine against <i>Mycobacterium avium</i> subspecies <i>paratuberculosis</i>. | The widespread chronic enteritis known as Paratuberculosis (PTB) or Johne's disease (JD) is caused by <i>Mycobacterium avium</i> subspecies <i>paratuberculosis</i> (MAP), posing a significant threat to global public health. Given the challenges associated with PTB or JD, the development and application of vaccines are ... |
39926703 | Effects of oxygen vacancies on hydrogenation efficiency by spillover in catalysts. | Hydrogen spillover is crucial for hydrogenation reactions on supported catalysts. The properties of supports have been reported to be very important for affecting hydrogen spillover and the subsequent hydrogenation process. The introduction of oxygen vacancies offers a promising strategy to enhance efficiency of cataly... |
39914287 | Recent advances in organic fluorescent probes for detecting phosgene, mustard gas, nerve agents and their mimics. | Chemical warfare agents (CWAs) have been notorious for a century, especially sarin and mustard gas, which have produced intolerable menace to civilian lives and environmental security. As a result, developing simple, rapid, portable, sensitive, and selective detection technologies for CWAs is critical. This review prim... |
39911838 | Advances in synthetic strategies for two-dimensional conjugated polymers. | Two-dimensional conjugated polymers (2D CPs) are typically represented by 2D conjugated covalent organic frameworks (COFs) that consist of covalently cross-linked linear conjugated polymers, which possess extended in-plane π-conjugation and out-of-plane electronic couplings. The precise incorporation of molecular build... |
39911344 | Enzymatic peptide macrocyclization <i>via</i> indole-<i>N</i>-acylation. | Indole <i>N</i>-acylation is chemically challenging, due to the low nucleophilicity of the indole nitrogen. Although a few similar transformations have been proposed in the biosynthesis of indole-containing natural products, their enzymatic basis remains elusive. Here, we show that BulbE TE is an <i>N</i>-acylindole-fo... |
39911336 | An encodable amino acid for targeted photocatalysis. | Photocatalysts are excellent scaffolds for the light-mediated control of bioactive molecules. Current photocatalytic structures are not compatible with genetic encoding and therefore cannot be directly incorporated into the sequences of native proteins. Herein, we developed new amino acids incorporating Si-rosamine pho... |
39908778 | Construction of an electrochemical sensor based on a conductive Ni<sub>3</sub>(HHTP)<sub>2</sub> nanowires array functionalized with ag nanoparticles@WS<sub>2</sub> QDs for nitrite detection. | A highly sensitive electrochemical nitrite sensor was developed by immobilizing silver nanoparticles (Ag NPs) and tungsten disulfide quantum dots (WS<sub>2</sub> QDs) on a conductive metal-organic frameworks (c-MOFs) consisting of Ni<sub>3</sub>(HHTP)<sub>2</sub> (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) nanowires... |
39906391 | Phase engineering of covalent triazine frameworks to enhance photocatalytic hydrogen evolution performance. | Photocatalytic water splitting for hydrogen production has been considered as an effective approach to address the current energy crisis and environmental challenges. Among all materials for such applications, covalent triazine frameworks (CTFs) are regarded as ideal candidates owing to their conjugated structures with... |
39904112 | Carbon and hydrogen isotope analysis of triacetone triperoxide using solid-phase microextraction coupled to GC-IRMS. | The source inference of triacetone triperoxide (TATP) is of great significance in the fight against crime. Isotope ratio mass spectrometry (IRMS) is a reliable method for accurately measuring the isotope ratio, and it has been successfully used to differentiate and trace various explosives, including TATP. However, the... |
39903978 | High-performance anion exchange membranes based on poly(oxindole benzofuran dibenzo-18-crown-6)s functionalized with hydroxyl and quaternary ammonium groups for alkaline water electrolysis. | Anion exchange membranes (AEMs) play a vital role in AEM water electrolysis (AEMWE), a promising technology for hydrogen production. However, developing AEMs that simultaneously achieve high OH<sup>-</sup> conductivity, robust alkaline stability and sustained operational performance in AEMWE remains challenging. In the... |
39892346 | Sustained release of gaseous chlorine dioxide from alpha-cyclodextrin: An innovative method for strawberry preservation. | The traditional method of generating chlorine dioxide (ClO<sub>2</sub>) involves reacting sodium chlorite with acid on-site, posing high safety risks of concentrated ClO<sub>2</sub>. This study encapsulates ClO<sub>2</sub> molecules directly in α-cyclodextrin (α-CD) to form inclusion complexes (ClO<sub>2</sub>@α-CD). T... |
39884625 | Octyl succinic anhydride-modified chitosan/oxidized sodium alginate Schiff base hydrogel loaded with terbinafine hydrochloride: pH-responsive, self-repairing, antifungal properties. | The application of hydrogels to drug delivery limited by the difficulty of encapsulating hydrophobic drugs; therefore, the development of novel composite hydrogels for the delivery of hydrophobic drugs is urgently needed. In this study, terbinafine hydrochloride/hydroxypropyl-β-cyclodextrin inclusion complexes (TFH/HP-... |
39884606 | Enhanced capacity in cellulose aerogel for carbon dioxide capture through modified by metal-organic framework. | Microporous metal-organic frameworks (MOF) exhibit excellent carbon dioxide (CO<sub>2</sub>) adsorption performance and selectivity for CO<sub>2</sub>/N<sub>2</sub> separation. However, the challenges associate with the recycling and reuse of MOF powders hinder their practical applications. To address these limitations... |
39884604 | Temperature-driven CsgA-enhanced mutant enable distinct self-assembly. | Functional coating materials have found extensive applications across various technological fields. However, the effectiveness of these coating depends critically on the choice of an appropriate medium. In this study, we developed an advanced "molecular glue", a CsgA variant known as CsgA-pro, which can serve as a vers... |
39884602 | A biomass-based "double-encapsulation structure" heightens the flame retardancy, antimicrobial effectiveness, and hydrophobicity of cotton fabric. | Due to the non-renewable nature of petroleum resources, there has been a notable shift toward utilizing biomass materials to confer flame retardant properties to cotton fabrics. However, endow solely with single function cannot meet the application requirements across various fields. Therefore, there is considerable im... |
39884593 | Crosslinked hydroxypropyl-β-cyclodextrin nanoparticles for improved efficacy of venetoclax against triple negative breast cancer. | Bcl-2 protein plays an integral role in hijacking apoptosis and triggering chemoresistance in triple negative breast cancer (TNBC). The present study explored the therapeutic efficacy of Bcl-2 inhibitor i.e., venetoclax (VTX) loaded HP-β-CD NPs (VTX/HP-β-CD NPs) against TNBC. VTX/HP-β-CD NPs were prepared using nanopre... |
39884590 | Supramolecular polymers: A perspective on the stability, biocompatibility and regulatory aspects. | Supramolecular polymers represent a distinctive class of polymers exhibiting similarities with covalent polymers, while also showcasing distinctive attributes such as responsiveness, reversibility, self-healing, and dynamism, which are conferred upon them by non-covalent interactions including hydrogen bonding, electro... |
39884535 | State-of-the-art progress and prospect of metal-organic frameworks and composites for photoelectrochemical amino-drugs sensing. | Unregulated discharge of antibiotics in waterbodies has posed a significant threat to the aquatic flora and fauna in post-pandemic times. This alarming situation has ascertained the need for suitable sensors to detect persistent antibiotic residues. In this context, functional hybrid materials centralized on reticular ... |
39884526 | Exploring the diagnostic landscape: Portable aptasensors in point-of-care testing. | Aptamers, discovered in the 1990s, have marked a significant milestone in the fields of therapeutics and diagnostics. This review provides a comprehensive survey of aptamers, focusing on their diagnostic applications. It especially encapsulates a decade of aptamer, encompassing research, patents, and market trends. The... |
39884521 | Orally-administrable supramolecular probiotic capsules enable cooperative colon-targeted inflammation inhibition for ameliorating ulcerative colitis. | Ulcerative colitis (UC) is a prevalent gastrointestinal disease characterized by the chronical and refractory inflammation of colorectal mucosa and walls, which severely impairs overall well-being of individuals. Probiotics has shown tremendous promise for UC therapy due to its multifaceted mucosal barrier restoration ... |
39882563 | From flat to twisted - multifunctional phosphacyclic nanocarbons based on Vat Orange 3. | The field of π-conjugated organic materials has seen significant advances in recent years. However, enhancing the functionality of well-established, mass-produced compounds remains a considerable challenge, despite being an intriguing strategy for designing high-value organic materials with low production costs. In thi... |
39882561 | Natural biomolecules for cell-interface engineering. | Cell-interface engineering is a way to functionalize cells through direct or indirect self-assembly of functional materials around the cells, showing an enhancement to cell functions. Among the materials used in cell-interface engineering, natural biomolecules play pivotal roles in the study of biological interfaces, g... |
39882506 | Emerging engineered nanozymes: current status and future perspectives in cancer treatments. | Composite nanozymes are composed of enzymes with similar or different catalytic capabilities and have higher catalytic activity than a single enzyme. In recent years, composite nanozymes have emerged as novel nanomaterial platforms for multiple applications in various research fields, where they are used to produce oxy... |
39877466 | Light-Programmable g-C<sub>3</sub>N<sub>4</sub> Microrobots with Negative Photogravitaxis for Photocatalytic Antibiotic Degradation. | Microrobots enhance contact with pollutants through their movement and flow-induced mixing, substantially improving wastewater treatment efficiency beyond traditional diffusion-limited methods. g-C<sub>3</sub>N<sub>4</sub> is an affordable and environmentally friendly photocatalyst that has been extensively researched ... |
39877465 | Soft Artificial Synapse Electronics. | Soft electronics, known for their bendable, stretchable, and flexible properties, are revolutionizing fields such as biomedical sensing, consumer electronics, and robotics. A primary challenge in this domain is achieving low power consumption, often hampered by the limitations of the conventional von Neumann architectu... |
39876669 | Enantioselective Catalytic Synthesis of Inherently Chiral Calixarenes. | Since the introduction of the concept of inherent chirality by Böhmer, an important part of research focused on the asymmetric synthesis of calixarene macrocycles. However, long synthetic procedures and tedious separation strategies hampered the application of this technology in many topics of organic chemistry, includ... |
39876589 | Lignin-Based Mucus-Mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity. | Mucus is a complex hydrogel that acts as a defensive and protective barrier in various parts of the human body. The rise in the level of viral infections has underscored the importance of advancing research into mucus-mimicking hydrogels for the efficient design of antiviral agents. Herein, we demonstrate the gram-scal... |
39876561 | Competing addition processes give distinct growth regimes in the assembly of 1D filaments. | We present a model to describe the concentration-dependent growth of protein filaments. Our model contains two states, a low-entropy/high-affinity ordered state and a high-entropy/low-affinity disordered state. Consistent with experiments, our model shows a diffusion-limited linear growth regime at low concentration, f... |
39876011 | The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers. | Both women and men are now confronted with the grave threat of cancers caused by the human papillomavirus (HPV). It is estimated that 80% of women may encounter HPV over their lives. In the preponderance of cases involving anal, head and neck, oral, oropharyngeal, penile, vaginal, vulvar, and cervical malignancies, hig... |
39876003 | Reductive acetogenesis is a dominant process in the ruminant hindgut. | <h4>Background</h4>The microbes residing in ruminant gastrointestinal tracts play a crucial role in converting plant biomass to volatile fatty acids, which serve as the primary energy source for ruminants. This gastrointestinal tract comprises a foregut (rumen) and hindgut (cecum and colon), which differ in structures ... |
39875991 | A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer. | Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens. Nucleolin (NCL) is overexpressed in many tumors, and drugs specifically targeting NCL may offer a promising strategy for treating esophageal cancer. Here, we designed... |
39875966 | Effect of early administration of fibrinogen replacement therapy in traumatic haemorrhage: a systematic review and meta-analysis of randomised controlled trials with narrative synthesis of observational studies. | <h4>Background</h4>In severely injured trauma patients, hypofibrinoginaemia is associated with increased mortality. There is no evidence-based consensus for what constitutes optimal fibrinogen therapy, treatment dose or timing of administration. The aim of this systematic review was to evaluate the effects of early fib... |
39875643 | Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom. | Using the UK Clinical Practice Research Datalink, our cohort study matched 237,297 individuals with hearing loss (HL) to 829,431 without HL. The study found an 8-10% higher risk of major osteoporotic fracture in individuals with HL compared to those without. Additionally, within the HL cohort, we identified risk factor... |
39875628 | Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance. | Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases. It is considered an intermediate stage in the evolution of bacteria towards full resis... |
39875548 | TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm. | Protein aggregation is a hallmark of many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), in which TDP-43, a nuclear RNA-binding protein, forms cytoplasmic inclusions. Here, we have developed a robust and automated method to assess protein self-assembly in the cytoplasm using microtubules as... |
39875539 | In situ construction of MOF derived CoNC anchored on N-doped carbon xerogel sphere as efficient bifunctional ORR/OER electrocatalyst for Zn-air batteries. | Electrocatalytic materials with dual functions of oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) have received increasing attention in the field of zinc-air batteries (ZABs) research. In this study, bifunctional CoNC@NCXS catalysts were prepared by anchoring Co and N co-doped CoNC on N-doped carbon... |
39875480 | Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy. | Nanobodies (Nbs) hold great potential to replace conventional antibodies in various biomedical applications. However, conventional methods for their discovery can be time-consuming and expensive. We have developed a reliable protein selection strategy that combines magnetic activated cell sorting (MACS)-based screening... |
39875424 | Ferromagnetic Fe-TiO<sub>2</sub> spin catalysts for enhanced ammonia electrosynthesis. | Magnetic field effects (MFE) of ferromagnetic spin electrocatalysts have attracted significant attention due to their potential to enhance catalytic activity under an external magnetic field. However, no ferromagnetic spin catalysts have demonstrated MFE in the electrocatalytic reduction of nitrate for ammonia (NO<sub>... |
39875380 | Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging. | Nanozymes play a pivotal role in mitigating excessive oxidative stress, however, determining their specific enzyme-mimicking activities for intracellular free radical scavenging is challenging due to endo-lysosomal entrapment. In this study, we employ a genetic engineering strategy to generate ionizable ferritin nanoca... |
39875319 | Partially Bonded Crystals: A Pathway to Porosity and Polymorphism. | In recent years, experimental and theoretical investigations have shown that anisotropic colloids can self-organize into ordered porous monolayers, where the interplay of localized bonding sites, so-called patches, with the particle's shape is responsible for driving the systems away from close-packing and toward poros... |
39875201 | Sequential and Time-Controlled Sol-Gel Transitions by Mechanical Switching of Molecular Tweezers. | Controlling the motion of molecular machines to influence higher-order structures is well-established in biological systems but remains a significant challenge for synthetic analogs. Herein, we aim to harness the mechanical switching of switchable molecular tweezers to modulate their self-assembly and produce stimuli-r... |
39875181 | Operando Electro-Oxidation Reconstitution of a Newly Designed 2D Co(II)-MOF on Nickel Foam to Cobalt Oxyhydroxide Nanosheets towards Energy Sustainability: A Holy Grail in Electrocatalytic Water Splitting. | The upsurging of cost-effective <i>de novo</i> electrocatalysts through the operando electro-oxidation approaches holds great promise for the scalable production of green energy in the pursuit of energy sustainability. This work introduces an operando electro-oxidation reconstitution strategy in producing a smart elect... |
39875119 | Chemically Triggered Reactive Coacervates Show Life-Like Budding and Membrane Formation. | Phase-separated coacervates can enhance reaction kinetics and guide multilevel self-assembly, mimicking early cellular evolution. In this work, we introduce "reactive" complex coacervates that undergo chemically triggered self-immolative transformations, directing the self-assembly of the reaction products within their... |
39875112 | Docking Structures Induced by Substitution Motifs of Softwood Xylan at Various Cellulose Surfaces. | To understand xylan-cellulose interactions in softwood, the adsorption behavior of hexameric softwood xylan proxies with various substitutions was analyzed on the three surfaces of a hexagonal cellulose microfibril. The study found that all surfaces could bind xylan motifs, showing equally high affinity for the hydroph... |
39874593 | Evaluation of Multipeptide Sequences Identified in Silico for the Serological Detection of Antibodies against Vector-Borne Diseases. | The socioecological conditions of Mexican regions are conducive to the spread of vector-borne diseases. Although there are established treatment guidelines for dengue and rickettsiosis, diagnosis is complicated. The objective of this work was to identify epitopes of Rickettsia and dengue virus that could be used in ser... |
39874537 | Interplay of Tetrel, Hydrogen, and Halogen Bonds in F<sub>3</sub>GeOCl and HCN Complexes: A Comprehensive Theoretical Study of Dimers, Trimers, and Tetramers. | This study investigates the nature and interplay of noncovalent interactions (NCIs)─tetrel bonds (TB), hydrogen bonds (HB), and halogen bonds (XB)─in molecular assemblies formed between trifluorogermyl hypochlorite (F<sub>3</sub>GeOCl) and hydrogen cyanide (HCN). Using a combination of high-level computational methods,... |
39874478 | Cu<sup>δ+</sup> Site-Enhanced Adsorption and Crown Ether-Reconfigured Interfacial D<sub>2</sub>O Promote Electrocatalytic Dehalogenative Deuteration. | Electrocatalytic dehalogenative deuteration is a sustainable method for precise deuteration, whereas its Faradaic efficiency (FE) is limited by a high overpotential and severe D<sub>2</sub> evolution reaction (DER). Here, Cu<sup>δ+</sup> site-adjusted adsorption and crown ether-reconfigured interfacial D<sub>2</sub>O a... |
39874356 | Investigating Pb2 CAP-binding domain inhibitors from marine bacteria for targeting the influenza A H5N1. | The ongoing increase in the prevalence and mutation rate of the influenza virus remains a critical global health issue. A promising strategy for antiviral drug development involves targeting the RNA-dependent RNA polymerase, specifically the PB2-cap binding domain of Influenza A H5N1. This study employs an in-silico ap... |
39874297 | Numerical analysis of sodium diffusion in aluminum electrolysis cathode carbon blocks based on a microstructure multi-factor corrected model. | Current researches on sodium penetration in electrolytic aluminum cathode carbon blocks primarily measure cathode expansion curves, showing mostly macroscopic characteristics. However, the microscopic structure is often underexplored. As a porous medium, the diffusion performance of cathode carbon blocks is closely tie... |
39874295 | Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis. | Carrier-free nanomedicines exhibited significant potential in elevating drug efficacy and safety for tumor management, yet their self assembly typically relied on chemical modifications of drugs or the incorporation of surfactants, thereby compromising the drug's inherent pharmacological activity. To address this chall... |
39874197 | Aspartate Metabolism-Driven Gut Microbiota Dynamics and RIP-Dependent Mitochondrial Function Counteract Oxidative Stress. | Aspartate (Asp) metabolism-mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain elusive. This study reports that chronic oxidative stress disrupts gut ... |
39874148 | Unraveling the Mechanism and Influence of Auxiliary Ligands on the Isomerization of Neutral [P,O]-Chelated Nickel Complexes for Olefin Polymerization. | The copolymerization of ethylene with polar monomers presents a significant challenge. While palladium catalysts have shown promise, nickel catalysts are more economical but suffer from poor activity. Previous studies suggest that the isomerization step involved in the nickel-catalyzed polymerization may influence the ... |
39874079 | Development of propranolol loaded SLN for transdermal delivery: <i>in-vitro</i> characterization and skin deposition studies. | <h4>Aim</h4>The study aimed to formulate solid lipid nanoparticles (SLNs) for the transdermal delivery of PPL to improve skin retention and efficacy.<h4>Materials and method</h4>The particle size distribution of SLNs was determined and the morphology of SLNs was also analyzed by SEM. <i>In-vitro</i>, <i>ex-vivo</i> and... |
39874057 | Aerolysin Nanopore Electrochemistry. | Ions are the crucial signaling components for living organisms. In cells, their transportation across pore-forming membrane proteins is vital for regulating physiological functions, such as generating ionic current signals in response to target molecule recognition. This ion transport is affected by confined interactio... |
39873807 | Head and Neck Classic Hodgkin, T and NK Lymphomas with Eosinophilia. | Eosinophilia is a notable feature in various hematological malignancies, including specific types of leukemias and lymphomas that may occur in the head and neck. In hematologic malignancies, eosinophilia can be primary, driven by genetic abnormalities, or secondary, resulting from cytokine and chemokine production by t... |
39873722 | Nanosensor for Fe(II) and Fe(III) Allowing Spatiotemporal Sensing <i>in Planta</i>. | Fluorescent nanosensors operating <i>in planta</i> have shown recent success toward informing basic plant biology and agricultural applications. We developed near-infrared (NIR) fluorescent nanosensors using the Corona Phase Molecular Recognition (CoPhMoRe) technique that distinguish Fe(II) and Fe(III) species with lim... |
39873634 | Heterogeneous Frustrated Lewis Pair Catalysts: Rational Structure Design and Mechanistic Elucidation Based on Intrinsic Properties of Supports. | ConspectusThe discovery of reversible hydrogenation using metal-free phosphoborate species in 2006 marked the official advent of frustrated Lewis pair (FLP) chemistry. This breakthrough revolutionized homogeneous catalysis approaches and paved the way for innovative catalytic strategies. The unique reactivity of FLPs i... |
39873629 | Fabrication of Hypoxia-Mimicking Supramolecular Hydrogels for Cartilage Repair. | Despite advancements in chronic arthritis treatment, there remains a significant demand for advanced nanotechnologies capable of efficiently delivering a wide range of therapeutic agents to provide symptomatic relief and facilitate the healing of inflamed cartilage tissue. Considering the significant impact of hypoxia ... |
39873636 | Carboxy-Amidated AamAP1-Lys has Superior Conformational Flexibility and Accelerated Killing of Gram-Negative Bacteria. | C-terminal amidation of antimicrobial peptides (AMPs) is a frequent minor modification used to improve antibacterial potency, commonly ascribed to increased positive charge, protection from proteases, and a stabilized secondary structure. Although the activity of AMPs is primarily associated with the ability to penetra... |
39873624 | Symmetry Breaking: Case Studies with Organic Cage-Racemates. | ConspectusSymmetry is a pervasive phenomenon spanning diverse fields, from art and architecture to mathematics and science. In the scientific realms, symmetry reveals fundamental laws, while symmetry breaking─the collapse of certain symmetry─is the underlying cause of phenomena. Research on symmetry and symmetry breaki... |
39873511 | c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in <i>Pseudomonas aeruginosa</i>. | The universal bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) plays critical roles in regulating a variety of bacterial functions such as biofilm formation and virulence. The metabolism of c-di-GMP is inversely controlled by diguanylate cyclases (DGCs) and phosphodiesterases (PD... |
39873498 | Laboratory evolution of <i>E. coli</i> with a natural vitamin B<sub>12</sub> analog reveals roles for cobamide uptake and adenosylation in methionine synthase-dependent growth. | Bacteria encounter chemically similar nutrients in their environment, which impact their growth in distinct ways. Among such nutrients are cobamides, the structurally diverse family of cofactors related to vitamin B<sub>12</sub> (cobalamin), which function as cofactors for diverse metabolic processes. Given that differ... |
39873298 | Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics. | Metabolic and insulin-resistant diseases, such as type 2 diabetes mellitus (T2DM), have become major health issues worldwide. The prevalence of insulin resistance in the general population ranges from 15.5% to 44.6%. Shockingly, the global T2DM population is anticipated to double by 2050 compared with 2021. Prior studi... |
39873288 | Peptide-Perovskite Based Bio-Inspired Materials for Optoelectronics Applications. | The growing demand for environmentally friendly semiconductors that can be tailored and developed easily is compelling researchers and technologists to design inherently bio-compatible, self-assembling nanostructures with tunable semiconducting characteristics. Peptide-based bioinspired materials exhibit a variety of s... |
39873213 | Structural Changes in Atomically Precise Ag<sub>29</sub> Nanoclusters upon Sequential Attachment and Detachment of Secondary Ligands. | Elucidating the structural dynamics of ligand-stabilized noble metal nanoclusters (NCs) is critical for understanding their properties and for developing applications. Ligand rearrangement at NC surfaces is an important contributor to structural change. In this study, we investigate the dynamic behavior of ligand-prote... |
39873184 | A Novel Polymersome Nanocarrier Promotes Anti-Tumour Immunity by Improved Priming of CD8 <sup>+</sup> T Cells. | Cancer is one of the leading causes of death worldwide. In recent years, immune checkpoint inhibitor therapies, in addition to standard immuno- or chemotherapy and surgical approaches, have massively improved the outcome for cancer patients. However, these therapies have their limitations and improved strategies, inclu... |
39873187 | Suppression of TGA2-Mediated Salicylic Acid Defence by Tomato Yellow Leaf Curl Virus C2 via Disruption of TCP7-Like Transcription Factor Activity in Tobacco. | Tomato yellow leaf curl virus (TYLCV) is a significant threat to tomato cultivation globally, transmitted exclusively by the whitefly Bemisia tabaci. While previous research suggests that the TYLCV C2 protein plays a role in fostering mutualistic interactions between the virus and its insect vectors, the specific mecha... |
39873110 | Mixed-Bridging 2D Luminescent Coordination Polymer: Structure, Selective Sensing of Pollutants in Water, and Fabrication of Photoresponsive Electronic Device. | Pyrazine (tppz) and 5-sulfosalicylic acid (H<sub>3</sub>SSA) mixed-bridging Cd(II)-CP, {[Cd<sub>2</sub>(HSSA)<sub>2</sub>(tppz)<sub>2</sub>]}<sub><i>n</i></sub> (<b>1</b>), is highly luminescent, and the emission has been quenched selectively by Al<sup>3+</sup> in the presence of other cations, with a limit of detectio... |
39873107 | Intensive and Persistent Chemiluminescence from Orderly Arranged Ligands within Metal-Organic Frameworks for Inflammation Imaging. | Chemiluminescence offers ultrasensitive imaging for the diagnosis of a variety of diseases by removing the interference from excitation light sources. Here, we prepared two chemiluminescent metal-organic frameworks (Mn-ADA and Zn-ADA) by using (2<i>E</i>,2'<i>E</i>)-3,3'-(anthracene-9,10-diyl)diacrylic acid (ADA) as a ... |
39871786 | Tailoring of Selective Chemo-Responsiveness in Liquid Crystals via Organic Ionic Plastic Crystals. | Liquid crystals (LCs) are widely used as promising stimuli-responsive materials due to their unique combination of liquid and crystalline properties, providing the capability to sense even molecular-scale events and amplify them into macroscopic optical outputs. However, encoding a high level of selectivity to a specif... |
39871764 | Fabrication of Dual-Functional MXene@NiCo<sub>2</sub>S<sub>4</sub> Composites with Enhanced Nonlinear Optical and Electrochemical Properties. | The design and synthesis of multifunctional nanomaterials have attracted considerable attention for expanding the range of practical applications. Herein, a metal-organic framework (MOFs)-derived NiCo<sub>2</sub>S<sub>4</sub> attached to MXene is rationally designed and constructed for an optical limiter and supercapac... |
39871766 | Adsorption and Separation by Flexible MOFs. | Flexible metal-organic frameworks (MOFs) offer unique opportunities due to their dynamic structural adaptability. This review explores the impact of flexibility on gas adsorption, highlighting key concepts for gas storage and separation. Specific examples demonstrate the principal effectiveness of flexible frameworks i... |
39871690 | The impact of different cooking temperatures on the quality and moisture distribution of beef. | The objective of this study was to investigate the water-holding capacity (WHC) and quality changes of beef during heating at specific temperatures (including 40 °C, 60 °C, 80 °C, and 100 °C), as well as the degradation of proteins and the distribution of water within the muscle at different heating temperatures. The e... |
39833118 | Scalable and Precise Synthesis of Structurally Colored Bottlebrush Block Copolymers: Enabling Refined Color Calibration for Sustainable Photonic Pigments. | Self-assembled bottlebrush block copolymers (BBCPs) offer a vibrant, eco-friendly alternative to traditional toxic pigments and dyes, providing vivid structural colors with significantly reduced environmental impact. Scaling up the synthesis of these polymers for practical applications has been challenging with convent... |
39832215 | Isoreticular Tolerance and Phase Selection in the Synthesis of Multi-Module Metal-Organic Frameworks for Gas Separation and Electrocatalytic OER. | Although metal-organic frameworks are coordination-driven assemblies, the structural prediction and design using metal-ligand interactions can be unreliable due to other competing interactions. Leveraging non-coordination interactions to develop porous assemblies could enable new materials and applications. Here, we us... |
39831898 | Carving Metal-Organic-Framework Glass Based Solid-State Electrolyte Via a Top-Down Strategy for Lithium-Metal Battery. | Traditional polymer solid electrolytes (PSEs) suffer from low ions conductivity, poor kinetics and safety concerns. Here, we present a novel porous MOF glass gelled polymer electrolyte (PMG-GPE) prepared via a top-down strategy, which features a unique three-dimensional interconnected graded-aperture structure for effi... |
39831519 | Carborane-Decorated Siloles with Highly Efficient Solid-State Emissions - What Drives the Photophysical Properties? | New hybrids were synthesised by linking carboranes and siloles, both of which are known as aggregation-induced emission active units. Although most of the newly synthesised systems do not display notable quantum yield either in solution or in the aggregated state, they emit strongly in the solid-state, and a quantum yi... |
39828595 | Interpenetration Control in Metal-Organic Polyrotaxanes via Solvent Composition and Ligand Steric-Modulation: Supramolecular Isomerism and Luminescence Detection toward Fe<sup>3+</sup> Ions. | Three fluorescent Zn coordaintion polymers (CPs) have been synthesized from the reactions of Zn(NO<sub>3</sub>)<sub>2</sub> ⋅ 6H<sub>2</sub>O, benzene-1,4-dicarboxylic acid (1,4-H<sub>2</sub>bdc), and angular carbazole-derived bispyridyl ligands (Cz-3,6-bpy or Cz-Pr-3,6-bpy). CPs 1-3 all adopt similar two-dimensional (... |
39825489 | From Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker. | Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defens... |
39821919 | Phosphorus-Nitrogen Heterocycles Derived from Chelating N-Donor Ligands: Historical Advances, Recent Highlights, and Outlook. | The exploration of phosphorus-nitrogen heterocycles derived from chelating N-donor ligands is an area of research that has lagged behind the development of similar heterocycles based on other main group elements, most notably boron. The fact that phosphorus and nitrogen are both group 15 elements and that their compoun... |
39821385 | Me<sub>2</sub>Se and Me<sub>2</sub>Te: Their Structures and Synergistic Effects of Halogen/Chalcogen Bonding with C<sub>6</sub>F<sub>5</sub>Br and C<sub>6</sub>F<sub>5</sub>I. | This work combines halogen and chalcogen bonding. Short, polarity directed C-X⋅⋅⋅Ch (X=Br or I, Ch=Se or Te) contacts were prepared by in situ low-temperature cocrystallization of liquid mixtures of neutral pentafluorohalogenobenzenes C<sub>6</sub>F<sub>5</sub>X and dimethyl chalcogenides Me<sub>2</sub>Ch. Solid-state ... |
39821355 | Organic Luminescent Cocrystals Based on Benzotriazole Derivatives: Synthesis, Characterization, Crystal Structure and Fluorescence Behavior. | Organic cocrystals have garnered significant research attention owing to their distinctive properties and promising applications. However, challenges in molecular structure design and control of intermolecular interactions continue to impede further advancements. In this study, two novel cocrystals were successfully fo... |
39817800 | Upgrade of Weak σ-Hole Bond Donors via Cr(CO)<sub>3</sub> Complexation. | Molecular recognition mediated by σ-hole interactions is enhanced as the electrostatic potential at the σ-hole becomes increasingly positive. Traditional methods to strengthen σ-hole donor ability of atoms such as halogens often involve covalent modifications, such as, introducing electron-withdrawing substituents (neu... |
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