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39817630 | Supramolecular Preorganization of Amine-functionalized Diacetylene Monomers in their Crystals Allows their Topochemical Polymerization to Polydiacetylenes Capable of CO<sub>2</sub> Capture. | We designed and synthesized three diacetylene monomers M1-M3 having two NH<sub>2</sub> groups. As anticipated, the NH<sub>2</sub> groups aided the preorganization of these monomers by N-H…N hydrogen bonding. In the crystals of monomer M1 and M2, the intermolecular N-H…N hydrogen bonding preorganized the diyne units in ... |
39817410 | Molecular Structural Control of the Amorphous-Crystalline Balance in Solids: Structure-Phase Correlation in DADQs with Enhanced/Switchable Fluorescence. | The amorphous/crystalline (A/C) assembly in molecular solids has a direct bearing on their attributes and applications, including mechanical, pharmaceutical, electronic and photophysical. A systematic analysis of the molecular features and interactions that determine the predilection towards the A, C or bi-stable A-C s... |
39817356 | Molecular Balances as Physical Organic Chemistry Tools to Quantify Non-Covalent Interactions. | Non-covalent interactions are present in numerous synthetic and biological systems, playing an essential role in vital life processes, such as the stabilization of proteins' structures or reversible binding in substrate-receptor complexes. Their study is relevant but faces challenges due to its inherent weak nature. In... |
39813092 | <sup>2</sup>H NMR as a Practical Tool for Following MOF Formation: A Case Study of UiO-66. | Developing the mechanism for MOF formation is crucial for the rapid development of new materials. This work demonstrates that Deuterium NMR spectroscopy is the optimal inter-laboratory methodology for understanding the in situ kinetics of metal-organic framework (MOF) formation. This method is facile, affordable, and a... |
39810701 | Pi-Stacking Geometry Directed Supramolecular Secondary Building Units Shaping Hydrogen-Bonded Frameworks for Intensive NH<sub>3</sub> Adsorption. | Exploiting supramolecular secondary building units (SSBUs) for developing porous crystalline materials represents an exciting breakthrough that extends the boundaries of reticular chemistry. However, shaping polynuclear clusters sustained by non-covalent interactions for the assembly of hydrogen-bonded frameworks remai... |
39807902 | Spin-Frustrated Metal-Organic Frameworks. | Metal-organic frameworks (MOFs) are a fascinating class of structured materials with diverse functionality originating from their distinctive physicochemical properties. This review focuses on the specific chemical design of geometrically frustrated MOFs along with the origin of the intriguing magnetic properties. We h... |
39807085 | Phenylphosphonic acid corroles: corroles that link and bind. | We report herein the synthesis and full spectroscopic characterization of two A<sub>2</sub>B-corrole phosphonic acids. Thanks to the presence of a phosphonic acid functional group at the 10-<i>meso</i>-position, the corroles were covalently linked to the hexanuclear Zr clusters of a PCN-222 metal-organic framework (MOF... |
39801298 | Significantly promoting the lithium-ion transport performances of MOFs-based electrolytes <i>via</i> a strategy of introducing fluoro groups in the crystal frameworks. | Metal-organic frameworks (MOFs) with well-ordered channels are considered ideal solid-state electrolytes (SSEs) for lithium ionic conductors and are expected to be utilized in all-solid-state Li-ion batteries. However, the outstanding Li<sup>+</sup> conductivity of MOFs, especially the properties at low temperatures, h... |
39791375 | Cr-MOF composited with facet-engineered bimetallic alloys for inducing photocatalytic conversion of CO<sub>2</sub> to C<sub>2</sub>H<sub>4</sub>. | The design of efficient photocatalysts is crucial for photocatalytic CO<sub>2</sub> reduction. This study developed photocatalysts based on MIL-101(Cr) composited with a facet-engineered Pt/Pd nanoalloy (PPNA). Photocatalytic performance evaluations show that MIL-101(Cr) loaded with PPNA exposing {111} facets, namely M... |
39779472 | Unsymmetric Triazine-Based Triglucoside Detergents for Membrane Protein Stability. | Membrane proteins play a crucial role in a variety of biological processes and are key targets for pharmaceutical development. Structural studies of membrane proteins provide molecular insights into the mechanisms of these processes and are essential for effective drug discovery. Historically, these studies have relied... |
39749408 | Anti-inflammatory and osteoconductive multi-functional nanoparticles for the regeneration of an inflamed alveolar bone defect. | Infected alveolar bone defects pose challenging clinical issues due to disrupted intrinsic healing mechanisms. Thus, the employment of advanced biomaterials enabling the modulation of several aspects of bone regeneration is necessary. This study investigated the effect of multi-functional nanoparticles on anti-inflamma... |
39704220 | Metal (M = Cr, Mo, W, Re) carbonyl complexes with porphyrin and carborane isocyanide ligands: light-induced oxidation and carbon oxide release for antitumor efficacy. | The tetrapyrrolic macrocycle as a scaffold for various chemical modifications provides broad opportunities for the preparation of complex multifunctional conjugates suitable for binary antitumor therapies. Typically, illumination with monochromatic light triggers the photochemical generation of reactive oxygen species ... |
39688496 | Phosphorus-containing polycarbosilazanes: synthesis <i>via</i> dehydrocoupling catalysis and flame-retardant properties. | The barium complex [Ba{N(SiMe<sub>3</sub>)<sub>2</sub>}<sub>2</sub>]<sub>2</sub> has been used to catalyse the dehydropolymerisation of the phosphine-functionalised hydrosilane 4-Ph<sub>2</sub>P-C<sub>6</sub>H<sub>4</sub>SiH<sub>3</sub> (A) with the α,ω-diamine 1,4-(CH<sub>2</sub>NHMe)<sub>2</sub>-C<sub>6</sub>H<sub>4<... |
39688315 | Structural transformation from a 3D hydrophilic pillared-layered framework to 2D hydrophobic MOF nanosheets through ligand replacement exfoliation. | A pillared-layered metal-organic framework (MOF) {[Zn<sub>2</sub>(atpt)<sub>2</sub>(bpBTD)]·<i>solv</i>}<sub><i>n</i></sub> (1), where H<sub>2</sub>atpt = 2-aminoterephthalic acid and bpBTD = bis(pyridin-4-yl)benzothiadiazole, showing a pcu net topology with double interpenetration was successfully constructed. Thermal... |
39687993 | Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes. | Polymeric carriers have long been recognized as some of the most effective and promising systems for nucleic acid delivery. In this study, we utilized an anionic di-block co-polymer, PEG-PLE, to enhance the performance of lipid-modified PEI (C14-PEI) nanoplexes for delivering Cas9 mRNA and sgRNA targeting KRAS G12S mut... |
39686728 | Helical Supramolecular Polymers Formed via Head-to-Tail Host-Guest Complexation of Chiral Bisporphyrin Monomers with Trinitrofluorenone. | The intermolecular host-guest complexation of head-to-tail monomers consisting of cleft-shaped bisporphyrin and trinitrofluorenone units connected by a chiral binaphthyl linker was employed to construct helically twisted supramolecular polymers. Results from <sup>1</sup>H NMR, diffusion-ordered NMR spectroscopy, and vi... |
39679562 | Acid-triggered size reduction of nanomedicines for enhancing tumor therapy efficacy. | Nanomedicines whose size can be varied on demand may synchronously achieve excellent tumor accumulation and penetration. In this study, by taking advantage of the pH sensitivity of a boronate ester, we synthesized acid-triggered size-reducing polymer nanoparticles (named PCD) by cross-linking β-cyclodextrin-cored multi... |
39676712 | Dual-linker Ir-Zr-MOF shows improved porosity to enhance aqueous sulfide photooxidation. | The hetero photooxidation of sulfide under aqueous conditions is of great importance in the green synthesis of sulfoxide. This process requires a type of solid photocatalyst with the properties of high porosity and water stability, as well as photosensitivity. Herein, a stable Ir-Zr-MOF material (compound 1) with high ... |
39670829 | Selective detoxification of a sulfur mustard simulant in air by a methylene blue-functionalized metal-organic framework. | Efficient degradation of sulfur mustard is essential owing to its extreme toxicity and widespread use as a chemical warfare agent. However, current degradation methods often lack selectivity and generate highly toxic by-products. Herein, we demonstrate an approach for the selective photodegradation of a sulfur mustard ... |
39569571 | Feasibility of controlled nitric oxide generation <i>via</i> ascorbate induced chemical reduction of nitrite ions. | Inhalable nitric oxide (iNO) is a lifesaving, FDA-approved drug to improve oxygenation in persistent pulmonary hypertension of the newborn. iNO also has many other applications in lung diseases owing to its vasodilatory and antimicrobial effects. However, its wider therapeutic application is often prohibited by the hig... |
39514364 | A Manual for Genome and Transcriptome Engineering. | Genome and transcriptome engineering have emerged as powerful tools in modern biotechnology, driving advancements in precision medicine and novel therapeutics. In this review, we provide a comprehensive overview of the current methodologies, applications, and future directions in genome and transcriptome engineering. T... |
39511750 | Organic BODIPY Based Gels: Optical, Electrochemical and Self-Assembly Properties. | Two novel BODIPY dyes, BOC3 and BC12, were synthesized with variable alkyl chains at terminal amide functional units. BC12, featuring a longer alkyl chain (-C<sub>12</sub>H<sub>25</sub>), formed a gel compared to BOC3, which has a shorter alkyl chain (< C->CH<sub>2</sub>OCH<sub>3</sub>), due to supra molecular self-ass... |
41889577 | Phytochemical, antioxidant, and antimicrobial properties of <i>Bellardia trixago</i> methanol and ethanol extracts: insights from ADMET and molecular docking approaches. | This study investigates the antioxidant, antimicrobial, and phytochemical properties of ethanol and methanol extracts derived from <i>Bellardia trixago</i> flowers alongside molecular docking and pharmacokinetic assessments of stigmasterol, a key bioactive compound. The antioxidant activities of the ethanol and methano... |
41809135 | Delivering living medicines with biomaterials. | The engineering of therapeutic living cells through genetic programming is poised to transform medicine. Diverse living medicines, including mammalian cells, fungi, bacteria, and viruses, are under development. However, for these medicines to progress in the clinic, new strategies are needed to successfully deliver the... |
40655122 | The Design of Intrinsically Conductive Metal-Organic Frameworks for Thermoelectric Materials. | Thermoelectric (TE) materials offer exciting promise in the development of sustainable, green energy alternatives. Ideal TE materials promote high electrical conductivity, whilst effectively scattering phonons for reduced thermal conductivity, thus giving the phonon-glass electron-crystal concept. Metal-organic framewo... |
40519970 | Tuning Topologically Nontrivial States in the BHT-Ni Metal-Organic Framework. | Using first-principles calculations, we have demonstrated the creation of multiple quantum states in the experimentally accessible metal-organic framework BHT-Ni. Specifically, quantum spin Hall and quantum anomalous Hall states are induced by two- and four-electron doping, respectively. Geometrical symmetry breaking i... |
40487090 | Multi-omics interpretation of how lysophospholipids regulate hepatic lipid metabolism and immunity in hybrid grouper (♀<i>Epinephelus fuscoguttatus</i> × ♂<i>Epinephelus Lanceolatu</i>) fed high-lipid diets. | This experiment explored the effects of lysophospholipids on hybrid grouper (initial average weight: 22.65 ± 0.03 g) hepatic lipid metabolism and immunity at the transcriptome and metabolome levels. A total of 375 hybrid groupers were divided into 5 groups of 3 replicates of 25 fish each. Five isoproteic and isolipidic... |
40463929 | Unveiling Synergistic Effectiveness of Strategically Designed Cobalt Clusters for Efficient Water Electrolysis. | Electrocatalytic water splitting is a challenging step toward hydrogen production to mitigate fossil fuel dependence. In nature, water oxidation is catalyzed by the Mn<sub>4</sub>CaO <sub><i>x</i></sub> cluster in photosystem-II, but the design of synthetic molecular catalysts still remains a challenge. A few catalysts... |
40385532 | Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different process parameters. | Monoclonal antibodies (mAbs) are commonly used biologic therapeutics with a wide variety of clinical applications. During the development process, manufacturers consider different production parameters to improve protein yield and achieve appropriate quality of the product. Synonymous gene recoding is one of such attri... |
40083928 | Recent advances in the mechanisms, current treatment status, and application of multifunctional biomaterials for radiation-induced skin injury. | Radiation-induced skin injury (RISI) is a prevalent complication following nuclear accidents and radiotherapy for tumors. The associated side effects may include erythema, desquamation, ulceration, and in severe cases, necrosis of certain skin tissues. These adverse reactions significantly impact the quality of life fo... |
40022373 | Physicochemical and rheological characteristics of commercial Greek-style yogurt enriched with Polygonum cuspidatum roots or the P. Cuspidatum β-cyclodextrin inclusion complex. | In this work, the effects of enriching commercial Greek-style yogurt with β-cyclodextrin-encapsulated Polygonum cuspidatum hydroalcoholic extract powder (YE) or P. cuspidatum root powder (YR) on the physicochemical properties of yogurt were compared. Greek-style yogurt was used as a control (YC). The yogurt samples wer... |
40022325 | Super antioxidant and high antibacterial ability bi-functional xylitol/2-hydroxypropyl-β-cyclodextrin carbon dots with hydroxyl-functionalized for rainbow trout preservation. | In 2020, Rainbow trout production reached 959,600 tons, representing 4 % of the global trout output. However, microbial contamination and lipid and protein oxidation spoil around 15 % of total aquatic products. Traditional food preservatives, used for their antibacterial or antioxidant properties, often fall short due ... |
40006940 | Isolation and Characterization of H1 Subtype Swine Influenza Viruses Recently Circulating in China. | Pigs serve as a mixing vessel for influenza viruses and can independently promote the emergence of pandemic strains in humans. During our surveillance of pig populations from 2021 to 2023 in China, 11 H1 subtype swine influenza viruses (SIVs) were isolated. All viruses were reassortants, possessing internal genes of id... |
40006936 | Insight into the Life Cycle of Enterovirus-A71. | Human enterovirus 71 (EV-A71), a member of the <i>Picornaviridae</i> family, is predominantly associated with hand, foot, and mouth disease in infants and young children. Additionally, EV-A71 can cause severe neurological complications, including aseptic meningitis, brainstem encephalitis, and fatalities. The molecular... |
40006673 | Revolutionizing Nanovaccines: A New Era of Immunization. | Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and have emerged as a promising platform for developing next-generation vaccines. Nanoparticles are revolutionizing the fie... |
40005651 | Investigating the Post-Mortem Risk of Transmission of SARS-CoV-2 Virus in Cadaveric Tissues: A Systematic Review of the Literature. | The emergence of SARS-CoV-2, responsible for the COVID-19 pandemic, has prompted extensive research into its transmission dynamics; yet, a critical aspect that remains underexplored is the post-mortem infectivity of the virus within cadaveric tissues. Understanding the mechanisms by which SARS-CoV-2 maintains infectivi... |
40005344 | Does Baseline Hounsfield Unit Predict Patients' Outcomes Following Surgical Management of Unstable Osteoporotic Thoracolumbar Fractures? | <i>Background and Objectives</i>: Osteoporotic fractures in the thoracic/lumbar spine pose significant challenges in surgical management, with high risks of complications. This study investigates the role of preoperative CT scans and Hounsfield Units (HUs) in predicting postoperative outcomes. <i>Materials and Methods<... |
40003401 | A Real-World Study on the Quality of Life of Consumers with Dentine Hypersensitivity and the Benefits of Hypersensitivity Toothpaste Use. | Dentine hypersensitivity (DH) causes pain from exposed dentine, triggered by external stimuli. Limited evidence exists on its impact on quality of life (QoL), the effectiveness of hypersensitivity toothpaste (HT) and the dental behaviors of DH sufferers. This study therefore aimed to generate evidence to address these ... |
39996637 | Advances in 3D and 4D Printing of Gel-Based Foods: Mechanisms, Applications, and Future Directions. | This review examines recent advancements in gel-based 3D and 4D food-printing technologies, with a focus on their applications in personalized nutrition and functional foods. It emphasizes the critical role of tunable rheological and mechanical properties in gels such as starch, protein, and Pickering emulsions, which ... |
39968525 | Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions. | Facial wrinkles include static and dynamic lines formed through different mechanisms and require diverse treatment approaches. Peptides perform well in anti-aging and wrinkle removal but exhibit poor transdermal efficiency. In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA... |
39968524 | Multifunctional liposome boosts glioma ferroptosis and immunotherapy through reinforcement of chemo-dynamic therapy strategy. | Glioma remains significant challenging to completely cure by the conventional surgical resection because of its high infiltrative growth properties. Recently, emerging immunotherapy has achieved remarkable success in treating various cancer, but glioma do not benefit from cancer immunotherapy owing to its specific immu... |
39959080 | Morphological and Electrical Properties of Proteinoid-Actin Networks. | Proteinoids, or thermal proteins, are produced by heating amino acids. Proteinoids form hollow microspheres in water. The microspheres produce oscillation of electrical potential. Actin is a filament-forming protein responsible for communication, information processing and decision making in eukaryotic cells. We synthe... |
39959035 | Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids. | This study reveals the significant effect of the proton pump inhibitor omeprazole on the spiking behavior of proteinoids, leading to a transformative shift in the field of unconventional computing. Through the application of different concentrations of omeprazole, we see a notable modification in the spiking characteri... |
39942680 | Influence of Deep Eutectic Solvent Composition on Micelle Properties: A Molecular Dynamics Study. | This study investigates the structural and transport properties of SDS, CTAB, and SB3-12 micelles in three deep eutectic solvents (DESs), Ethaline, Glyceline, and Reline, using molecular dynamics (MD) simulations. The influence of solvent composition on micelle morphology, interactions, and dynamics was explored, revea... |
39942674 | Aggregachromic Fluorogenic Asymmetric Cyanine Probes for Sensitive Detection of Heparin and Protamine. | The precise and fast detection of heparin, the most widely used anticoagulant, remains a significant challenge for assessing its use in a clinical setting. In this work, we adapt a well-established asymmetric cyanine fluorogenic platform for the purpose of ultrasensitive heparin detection in the presence of common inte... |
39942672 | Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune Disorders. | The interaction between the neuroendocrine system and the immune system plays a key role in the onset and progression of various diseases. Neuropeptides, recognized as common biochemical mediators of communication between these systems, are receiving increasing attention because of their potential therapeutic applicati... |
39942236 | Advanced Platelet-Rich Fibrin (A-PRF) as Antibiotics Delivery System: In-Vitro Proof-of-Concept Study. | Autologous blood centrifugation produces various forms of platelet concentrates widely used in tissue regenerative therapies due to their high concentrations of growth factors and abundance of autologous cells. Advanced Platelet-Rich Fibrin (A-PRF), introduced as a low-speed centrifugation product, contains an even hig... |
39942009 | Food-Grade Pickering Emulsions Stabilized by Ultrasound-Treated Foxtail Millet Prolamin: Characterization and <i>In Vitro</i> Release Behavior of Curcumin. | To date, extensive studies have focused on developing proteins as stabilizers to fabricate food-grade emulsions for encapsulating bioactive compounds aimed at targeted delivery. This paper aimed to develop a novel stabilizer using foxtail millet prolamin (FMP) to fabricate medium internal-phase Pickering emulsions (MIP... |
39941510 | Effects of Physical Exercise on Neurofilament Light Chain and Glial Fibrillary Acidic Protein Level in Patients with Multiple Sclerosis: A Systematic Review and Bayesian Network Meta-Analysis. | <b>Background:</b> The prognosis of people with multiple sclerosis (MS) has improved substantially in recent decades due to advances in diagnosis and treatment. Due to the unpredictable course and heterogenous treatment response in MS, there is a clear need for biomarkers that reflect disease activity in the clinical f... |
39940882 | Cellular and Molecular Mechanisms Modulated by Genistein in Cancer. | Genistein (4',5,7-trihydroxyisoflavone) is a phytoestrogen belonging to a subclass of natural flavonoids that exhibits a wide range of pharmacological functions, including antioxidant and anti-inflammatory properties. These characteristics make genistein a valuable phytochemical compound for the prevention and/or treat... |
39940884 | Adult Leigh Syndrome Associated with the m.15635T>C Mitochondrial DNA Variant Affecting the Cytochrome <i>b</i> (<i>MT-CYB</i>) Gene. | We report on a sporadic patient suffering Leigh syndrome characterized by bilateral lesions in the lenticular nuclei and spastic dystonia, intellectual disability, sensorineural deafness, hypertrophic cardiomyopathy, exercise intolerance, and retinitis pigmentosa. Complete sequencing of mitochondrial DNA revealed the h... |
39940877 | The Molecular Mechanism of <i>Clock</i> in Thermal Adaptation of Two Congeneric Oyster Species. | Clock genes regulate physiological and metabolic processes by responding to changes in environmental light and temperature, and genetic variations in these genes may facilitate environmental adaptation, offering opportunities for resilience to climate change. However, the genetic and molecular mechanisms remain unclear... |
39940870 | Discovery of Crinasiadine, Trisphaeridine, Bicolorine, and Their Derivatives as Anti-Tobacco Mosaic Virus (TMV) Agents. | Plant viral diseases cause great harm to crops in terms of yield and quality. Natural products have been providing an excellent source of novel chemistry, inspiring the development of novel synthetic pesticides. The Amaryllidaceae alkaloids crinasiadine (<b>3a</b>), trisphaeridine (<b>4a</b>), and bicolorine (<b>5a</b>... |
39940867 | Identification of DDR1 Inhibitors from Marine Compound Library Based on Pharmacophore Model and Scaffold Hopping. | Ulcerative colitis (UC) is a chronic inflammatory condition that affects the intestines. Research has shown that reducing the activity of DDR1 can help maintain intestinal barrier function in UC, making DDR1 a promising target for treatment. However, the development of DDR1 inhibitors as drugs has been hindered by issu... |
39940856 | Preparation of Diosgenin-Functionalized Gold Nanoparticles: From Synthesis to Antitumor Activities. | Cancer ranks among the top causes of illness and death globally. Nanotechnology holds considerable promise for enhancing the effectiveness of therapeutic and diagnostic approaches in cancer treatment. Our study presents a promising strategy for applying thiocompound nanomedicine in cancer therapy. Our first study aimed... |
39940863 | Potential Molecular Interactions and In Vitro Hyperthermia, Thermal, and Magnetic Studies of Bioactive Nickel-Doped Hydroxyapatite Thin Films. | The treatment of bone cancer often necessitates the surgical removal of affected tissues, with artificial implants playing a critical role in replacing lost bone structure. Functionalized implants represent an innovative approach to improve bio-integration and the long-term effectiveness of surgery in treating cancer-d... |
39940851 | G3BP1 Regulates the Cell Cycle by Promoting IFNβ Production to Promote PCV2 Replication and Promotes Nuclear Transfer of Viral Proteins by Direct Binding. | Porcine circovirus type 2 (PCV2) is a significant pathogen responsible for porcine circovirus-associated diseases (PCVAD), and it is widely prevalent in pig farms, leading to huge economic losses for the pig industry. Currently, the ability of PCV2 to enhance its own replication by using the antiviral inflammatory fact... |
39940547 | Experimental and Theoretical Analysis of Dopamine Polymerization on the Surface of Cellulose Nanocrystals and Its Reinforcing Properties in Cellulose Acetate Films. | The study of natural materials inspires sustainable innovations, with biomimetics excelling in surface modification. Polydopamine (PDA) offers a promising approach for modifying cellulose nanocrystals (CNC), enhancing their compatibility with hydrophobic polymers by improving interfacial adhesion. In this work, the mod... |
39940550 | Physicochemical Properties of Nanoencapsulated Essential Oils: Optimizing D-Limonene Preservation. | Essential oils exhibit antioxidant properties but are prone to oxidative degradation under environmental conditions, making their preservation crucial. Therefore, the purpose of this work was to evaluate the physicochemical properties of nanoencapsulated essential oils (EOs) extracted from the peel of sweet lemon, mand... |
39940552 | Predicting the Key Properties of a Modified Product to Pre-Select a Pluronic F127 Modification Scheme for Preparing High-Quality Nano-Micelles. | Hydrophobic modification alters the properties of Pluronic F127 to form micelles more efficiently and enhances its drug-loading capacity. However, selecting the appropriate hydrophobic group for modification is laborious. In this paper, we propose an efficient approach for predicting key parameters to select hydrophobi... |
39940182 | Functionalized Optical Microcavities for Sensing Applications. | Functionalized optical microcavities constitute an emerging highly sensitive and highly selective sensing technology. By combining optical microcavities with novel materials, microcavity sensors offer exceptional precision, unlocking considerable potential for medical diagnostics, physical and chemical analyses, and en... |
39940181 | Applications of MOF-Based Nanocomposites in Heat Exchangers: Innovations, Challenges, and Future Directions. | Metal-organic frameworks (MOFs) have garnered significant attention in recent years for their potential to revolutionize heat exchanger performance, thanks to their high surface area, tunable porosity, and exceptional adsorption capabilities. This review focuses on the integration of MOFs into heat exchangers to enhanc... |
39935688 | Identification and functional validation of a new gene conferring resistance to <i>Soybean Mosaic Virus</i> strains SC4 and SC20 in soybean. | Soybean Mosaic Virus (SMV) poses a serious threat to soybean production, often resulting in considerable yield losses or complete crop failure, particularly if infection occurs during early growth stages. While several SMV resistance genes have been identified, the genetic basis of resistance to certain strains remains... |
39931690 | Inhibition of high glucose-induced cardiac fibroblast activation: an effective treatment for diabetic cardiomyopathy using Chinese herbal medicine. | Diabetic cardiomyopathy (DCM) is one of the common diabetic microangiopathy in clinical practice. In the early stage of the disease, there are no obvious clinical symptoms. In the middle and late stages, MF, arrhythmia, and even heart failure may occur, affecting the life and health of patients. MF, as one of the patho... |
39931631 | Genome drafting of nosocomial infection CRE <i>Klebsiella pneumoniae</i> confirming resistance to colistin and eravacycline, carrying <i>bla</i> <sub>NDM-1</sub>, <i>mcr-1</i>, and <i>bla</i> <sub>KPC-2</sub>, in neonatology from November to Decemb... | <h4>Background</h4>Carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) is a critical pathogen in healthcare settings, associated with high mortality due to its extensive antibiotic resistance. In this study, we report an outbreak of CRKP in a neonatal intensive care unit (NICU) within a 200-bed tertiary hospital. ... |
39931278 | Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification of <i>Leishmania major</i> in cutaneous leishmaniasis patients. | <h4>Introduction</h4>Cutaneous leishmaniases (CL), a wide range of cutaneous diseases caused by diverse species of <i>Leishmania</i> genus parasites, are among the most neglected infectious diseases. While they are non-fatal, CL are highly morbid with disfiguring lesions, which could be chronic, leaving lifelong unsigh... |
39926413 | Nanotherapeutic smart approaches for combating Alzheimer's disease and overcoming existing obstacles: A novel eco-friendly green approach. | The scientific community has united to raise awareness of Alzheimer's disease (AD) as a critical condition for future generations because recent predictions indicate that it will become common among the elderly within a few years. Nevertheless, the intricacies of the disease's progression demand exhaustive investigatio... |
39922039 | "Illuminated Glycoporphyrins": A photodynamic approach for Candida albicans inactivation. | The continuous increase in the incidence of invasive mycoses, particularly those caused by Candida albicans, is a relevant health issue worldwide due to the lack of effective antifungals and the constant emergence of resistant strains. One of the most promising therapies to treat infections caused by resistant microorg... |
39921979 | Colorimetric sensor comprising metal-organic frameworks and molecularly imprinted polymers for aflatoxin B1 detection in agricultural commodities. | A novel colorimetric sensor was developed by integrating cerium metal-organic frameworks with molecularly imprinted polymers (Ce-MOF@MIP) for the highly selective and sensitive detection of Aflatoxin B1. The resulting composite leverages the peroxidase-like activity of cerium metal-organic frameworks to catalyze the ox... |
39916885 | Copper(ii)-catalyzed enantioselective decarboxylative Mannich reaction coordinated by supramolecular organic amine cages. | Using supramolecular chiral cages to create a favorable chiral environment can effectively address the limitations of traditional metal asymmetric catalysis in controlling chiral catalytically active centers. However, achieving harmonious interactions among the molecular cage, the metal, and the substrate within the ca... |
39893781 | Multifunctional nanozymes for sonodynamic-enhanced immune checkpoint blockade therapy by inactivating PI3K/AKT signal pathway. | Insufficient activation efficacy and tumor immunosuppressive microenvironments hinder the infiltration of cytotoxic T lymphocytes (CTLs) for effective immunotherapy. Herein, the pH-selective multienzyme-mimetic nanozymes have been developed based on Pd-hemoporfin (Pd<sup>0</sup>/Pd<sup>2+</sup>‒H) nanoagents for tumor ... |
39893722 | Unraveling the trisubstrate-triproduct reaction mechanisms of wine grape VvCYP76F14 to improve wine bouquet. | Bouquet is a captivating wine characteristic that affects consumer consumption. Wine lactone correlates with both precursor ((E)-8-carboxylinalool) concentration and wine age that has the greatest contribution to bouquet. In wine grape, cytochrome P450 VvCYP76F14 can catalyze trisubstrate-triproduct reaction processes ... |
39892012 | Unveiling non-monotonic deformation of flexible MOFs during gas adsorption: From contraction and softening to expansion and hardening. | Flexibility of metal-organic frameworks (MOFs) plays an important role in their applications, particularly in adsorption separations, energy and gas storage, and drug delivery. As an important practical example, we study adsorption of CH<sub>4</sub>, and CO<sub>2</sub> on isoreticular MOF-1 (IRMOF-1) crystal at differe... |
39889641 | Supramolecular recognition, fluorescence, and sensing: Two trilobal dyes and casein in milk. | We describe here two trilobal dyes called aniline blue (AB) and light green SF yellowish (LGSF) for their supramolecular recognition with casein, the principal protein in milk. The trilobal dyes bind con-covalently with casein as demonstrated by various approaches including docking and isothermal titration calorimetry.... |
39889554 | Spiropyran-based triphenylamine AlEgens: pH-responsive and light-activated mitochondria-targeted fluorescence imaging. | Mitochondria are important sites of energy metabolism in eukaryotic cells and are critical for cellular physiological functions, which are closely related to mitochondrial pH (∼8.0). In this work, novel smart-responsive fluorescent probes TOCy3 and MTOCy3 for visualizing pH changes in the mitochondrial microenvironment... |
39889505 | Single-molecule resolution of macromolecules with nanopore devices. | Nanopore-based electrical detection technology holds single-molecule resolution and combines the advantages of high sensitivity, high throughput, rapid analysis, and label-free detection. It is widely applied in the determination of organic and biological macromolecules, small molecules, and nanomaterials, as well as i... |
39886340 | P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice. | <b>Purpose:</b> Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel tha... |
39884123 | Reliable and specific biosensing on single- and double-stranded aptamer functionalized remote dual-gate organic field-effect transistors: A comparison. | Organic field-effect transistors (OFETs) integrated with commercial transistors are promising sensing platforms characterized by enhanced device uniformity, functional diversity, and electrical output stability. Aptamers with charged backbones and a high affinity for target molecules are anticipated to mitigate the lim... |
39884092 | MOF-derived FeCe@Carbon catalysts for the efficient tetracycline degradation by activated persulfate: Preparation and mechanistic study. | Metal-organic frameworks (MOFs) derived materials are extensively utilized in wastewater treatment owing to their remarkable catalytic efficacy and durability. This study exploited iron-cerium-based bimetallic metal-organic framework (FeCe-MOF) as a sacrificial template, which was subsequently calcined at 700 °C to pro... |
39884037 | Electroactive biofilms alter the EPS structure and metabolic pathways to sense potential and tetracycline. | The extracellular polymeric substances (EPS) secretion decides the efficiency of microbial electron transfer and the resistance to toxic challenges. Electrode potential is a critical factor affecting both the rate and direction of electron transfer. However, the mechanism through which potential regulates EPS structure... |
39884002 | Revealing structure-performance relationship of biomimetic cyclodextrin metal-organic framework composite electrolytes for dendrite-free lithium metal batteries. | Cyclodextrin metal-organic frameworks (CD-MOFs) with infinitely extensible network structures show potential applications in lithium metal batteries. However, the disordered accumulation of CD-MOF particles leads to slow interparticle diffusion of ions, so the CD-MOF composite electrolytes are needed to be developed. I... |
39883996 | Label-free electrochemical immunosensors based on Cu-Ni metal-organic framework and carbon nanotube composite for carcinoembryonic antigen detection. | Monitoring cancer biomarkers is of great significance in clinical diagnosis. In this work, a label-free MWCNTs-COOH/CuNi-BTC/FTO electrochemical immunosensor was developed to quantitatively detect carcinoembryonic antigen (CEA). The bimetallic CuNi-BTC showed enhanced current than singe Ni-BTC, and the addition of the ... |
39880264 | Trehalose decorated nanostructures stabilize combined cross-linked enzyme aggregates (Combi-CLEAs) of β-galactosidase and glucose isomerase. | Combined cross-linked enzyme aggregates (Combi-CLEAs) of β-Galactosidase (β-Gal) and Glucose Isomerase (GI) allow the transformation of d-lactose to lactose-fructose syrup through one-pot cascade biocatalytic reactions. Despite its promise, the low thermostability of β-Gal and high-temperature demands for GI limits thi... |
39880254 | Multifunctional quaternary ammonium-modified TEMPO-oxidized cellulose nanofibers and MIL-100 with encapsulated laccase for efficient removal of anionic arund cationic dyes in wastewater. | The increasing prevalence of micropollutants like cationic and anionic dyes in wastewater creates an influential environmental challenge, mainly due to their toxic effects and persistence. Current methods often lack the efficiency and versatility to cope with a wide variety of contaminants. This study explores the modi... |
39880225 | Amyloid capture and aggregation inhibition by human serum albumin. | Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-beta (Aβ) aggregation, primarily involving the peptides Aβ40 and Aβ42. Human serum albumin (HSA) has emerged as a potential therapeutic agent due to its ability to bind Aβ, inhibit aggregation, and promote disaggregation. This s... |
39880167 | Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties. | Phosphatidic acid (PA) through its unique negatively charged phosphate headgroup binds to various proteins to modulate multiple cellular events. To perform such diverse signaling functions, the ionization and charge of PA's headgroup rely on the properties of vicinal membrane lipids and changes in cellular conditions. ... |
39880097 | Apolipoprotein E3 and E4 isoforms exhibit differing effects in countering endotoxins. | Apolipoprotein E (APOE) is distributed across various human tissues and plays a crucial role in lipid metabolism. Recent investigations have uncovered an additional facet of APOE's functionality, revealing its role in host defense against bacterial infections. To assess the antibacterial attributes of APOE3 and APOE4, ... |
39880075 | Zn-doped CaP coating equips Ti implants with corrosion resistance, biomineralization, antibacterial and immunotolerant activities. | <h4>Introduction</h4>Chronic inflammation leading to implant failure present major challenges in orthopedics, dentistry, and reconstructive surgery. Titanium alloys, while widely used, often provoke inflammatory complications. Zinc (Zn)-doped calcium phosphate (CaP) coatings offer potential to enhance implant integrati... |
39877820 | Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines. | Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to ... |
39877814 | Co<sup>II</sup>-organic 'soft' metallo-supramolecular polymer nanofibers for efficient photoreduction of CO<sub>2</sub>. | Coordination-driven metallo-supramolecular polymers hold significant potential as highly efficient catalysts for photocatalytic CO<sub>2</sub> reduction, owing to the covalent integration of the light harvesting unit, catalytic center and intrinsic hierarchical nanostructures. In this study, we present the synthesis, c... |
39876925 | Construction of an MXene/MIL Fe-53/ZIF-67 derived bifunctional electrocatalyst for efficient overall water splitting. | Research on water splitting is paramount for developing low-carbon alternative energy sources. Nevertheless, creating an efficient, cost-effective, and bifunctional electrocatalyst that facilitates both the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER) remains an elusive goal. In this work, ... |
39874793 | A novel separated OPECT aptasensor based on MOF-derived BiVO<sub>4</sub>/Bi<sub>2</sub>S<sub>3</sub> type-II heterojunction for rapid detection of bacterial quorum sensing signal molecules. | Quorum sensing signal molecules released by microorganisms serve as critical biomarkers regulating the attachment and aggregation of marine microbes on engineered surfaces. Hence, the development of efficient and convenient methods for detecting quorum sensing signal molecules is crucial for monitoring and controlling ... |
39874775 | Enhancing strategies of MOFs-derived materials for microwave absorption: review and perspective. | Microwave absorption materials (MAMs) gradually exhibit crucial applications in reducing electromagnetic wave (EMW) pollution, avoiding EMW information leakage, and solving radar stealth. Metal-organic frameworks (MOFs)-derived materials are flourishing in the domain of EMW absorption attributed to their especial struc... |
39871979 | A cost-effective and innovative detector for iron ions. | Severe environmental contamination can result from high concentrations of iron ions, which can have a detrimental impact on human health and well-being. Consequently, it is imperative to develop novel materials that can address environmental issues. Metal-organic frameworks (MOFs) possess unique properties that render ... |
39871974 | Hierarchical structures of GO-supported BiBTC MOFs for efficient RhB photodegradation. | This study, we synthesized a graphene oxide@BiBTC MOF (GO@BiBTC) photocatalyst <i>in situ</i> using a hydrothermal method. The resulting samples were comprehensively characterized using FT-IR, Raman spectra, XRD, SEM, TEM, XPS and UV-Vis spectroscopy. The photodegradation reaction fits the pseudo-first-order kinetics a... |
39871972 | Study on gas adsorption and separation performance of alkyl functionalized MOF materials under wet conditions. | Metal-organic framework materials exhibit significant potential for diverse applications in gas adsorption and separation. We have studied the performance changes of Cu-BTC, Cu-MBTC and Cu-EBTC under different water-containing conditions. GCMC studies shows that, compared with Cu-BTC, the water absorption properties of... |
39871586 | Naturally derived hydrogels for wound healing. | Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity and excellent biocompatibility create an ideal moist environment for wound healing, thereby enhancing cell proliferation and tissue regeneration. For this reason, na... |
39871506 | Large and Stable Nanopores Formed by Complement Component 9 for Characterizing Single Folded Proteins. | Biological nanopores offer a promising approach for single-molecule analysis of nucleic acids, peptides, and proteins. The work presented here introduces a biological nanopore formed by the self-assembly of complement component 9 (C9). This exceptionally large and cylindrical protein pore is composed of 20 ± 4 monomers... |
39871499 | Construction and Band Gap-Regulation of Ordered Macro-Microporous Single Crystals of an Amine-Linked Covalent Organic Framework. | Heterogeneity engineering provides an effective route to manipulate the chemical and physical properties of covalent organic frameworks (COFs) but is still under development for their single-crystal form. Here, we report the strategy based on a combination of the template-assisted modulated synthesis with a one-pot cry... |
39871476 | Cobalt-Cluster-Based Metal-Organic-Framework-Catalyzed Carboxylative Cyclization of Propargylic Amines with CO<sub>2</sub> from Flue Gas. | The fixation of carbon dioxide (CO<sub>2</sub>) directly from flue gas into valuable chemicals like 2-oxazolidinones is of great significance for economic and environmental benefits, which is typically catalyzed by noble-metal catalysts and under harsh conditions. Herein, a novel 2-fold interpenetrated framework {[Co<s... |
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