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39940531 | Structure-Properties Correlations in Novel Copoly(urethane-imide) Films Selectively Destructed Under Thermolysis and Hydrolysis in Alkaline Media. | The paper describes changes in the structure, morphology, mechanical and thermal properties of porous film samples of poly(4,4'-oxidiphenylene)pyromellitimide prepared as a result of selective destruction of urethane blocks in copolymers composed of pyromellitimide blocks and polyurethane blocks. The initial samples of... |
39940530 | Cellulose-Based Composite Materials for Fresh Water Extraction from Atmospheric Air. | The fibrous hybrid material was synthesized by suspension radical styrene polymerization on the surface of cellulose microfibers. The resulting material was used to prepare a thermally stable and mechanically strong porous composite matrix that was employed as a carrier for further precipitation of the hygroscopic agen... |
39940528 | Cutting-Edge Sensor Design: MIP Nanoparticle-Functionalized Nanofibers for Gas-Phase Detection of Limonene in Predictive Agriculture. | As population growth and climate change intensify pressures on agriculture, innovative strategies are vital for ensuring food security, optimizing resources, and protecting the environment. This study introduces a novel approach to predictive agriculture by utilizing the unique properties of terpenes, specifically S(-)... |
39936977 | Monensin Inhibits Triple-Negative Breast Cancer in Mice by a Na<sup>+</sup>-Dependent Cytotoxic Action Unrelated to Cytostatic Effects. | Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype, defined by its limited therapeutic options and poor outcomes. This study investigated the therapeutic potential of targeting Na<sup>+</sup> homeostasis in TNBC cells to induce TNBC inhibition. For this purpose, BALB/c mice were i... |
39936123 | A multistimuli responsive and self-healing Zn(ii)-inosine supramolecular metal-organic gel: phase selective gelation and application as a light-responsive Schottky barrier diode. | Utilization of naturally available biomolecules such as nucleosides with several coordination sites as organic counterparts for the synthesis of multifunctional self-assembled metal-organic gels is important, considering the time and efforts required for the design of organic ligands that can coordinate to metal ions, ... |
39929048 | Emulsion gels stabilized by cyclodextrin inclusion/chitosan complexes with varying OSA substitution degree for co-encapsulation of bioactive compounds. | Co-encapsulation of bioactive compounds using interfacial β-cyclodextrin (β-CD) cavities and the internal oil phase of emulsion gels presents a promising approach. This study prepared octenyl succinic anhydride (OSA)-modified cyclodextrin-resveratrol (OCD-R) inclusion complexes with varying substitution degrees (DS) an... |
39914301 | Effect of intermediate polarity molecule on phase transitions and bilayer structure in phospholipid membranes. | Lipid-based formulations are widely utilized in various applications including food, cosmetics, and pharmaceuticals. The properties of these formulations can be influenced by changes in the external environment. As one example, dehydration can induce phase changes and alter the structural organization and molecular dyn... |
39911340 | Regioselective late-stage functionalization of tetraphenylenes: rapid construction of double helical architectures and potential hole transport materials. | Herein we report a novel approach for diversification of tetraphenylene <i>via</i> regioselective late-stage iodination followed by atom(s) insertion into the resulting cyclic iodonium salts. Thus, the steric hindrance effect of <i>tert</i>-butyl facilitates the regioselective synthesis of two cyclic iodonium salts of ... |
39908838 | Living organisms growth and release immobilized in an assembled dipeptide hydrogel. | Self-assembled dipeptide hydrogel provides three-dimensional networks through noncovalent interactions for the embedment and the release of multiple biocomponents as well as for the growth of live cells. Here we demonstrate that Caenorhabditis elegans (C. elegans) as model organisms can be immobilized with significant ... |
39881670 | Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology. | Silk protein, as a natural polymer material with unique structures and properties, exhibits tremendous potential in the biomedical field. Given the limited production and restricted properties of natural silk proteins, molecular biotechnology has been extensively applied in silk protein genetic engineering to produce n... |
39879747 | A dual action electrochemical molecular imprinting sensor based on FeCu-MOF and RGO/PDA@MXene hybrid synergies for trace detection of ribavirin. | In this study, we designed a molecularly imprinted electrochemical sensor based on the reduced graphene oxide/polydopamine@Mxene (RPM) and FeCu-MOF for the detection of antiviral drug ribavirin (RBV). The RPM composite enhances the active surface area and electron transport capacity of the sensor, and the incorporation... |
39877587 | LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy. | <h4>Background</h4>Colorectal cancer (CRC) is a highly malignant and aggressive gastrointestinal tumor. Due to its weak immunogenicity and limited immune, cell infiltration lead to ineffective clinical outcomes. Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient ... |
39872470 | Therapeutic exploration potential of adenosine receptor antagonists through pharmacophore ligand-based modelling and pharmacokinetics studies against Parkinson disease. | Parkinson's Disease (PD) is a neurodegenerative disorder that primarily affects persons aged 65 and older. It leads to a decline in motor function as a result of the buildup of abnormal protein deposits called Lewy bodies in the brain. Existing therapies exhibit restricted effectiveness and undesirable side effects. Th... |
39870342 | Cobalt regulation biocathode with sulfate-reducing bacteria for enhancing the reduction of antimony and the removal of sulfate in a microbial electrolysis cell simultaneously. | Antimony (Sb) contamination in water resources poses a critical environmental and health challenge globally. Sulfate reducing bacteria (SRB) are employed to reduce SO<sub>4</sub><sup>2</sup><sup>-</sup> to S<sup>2</sup><sup>-</sup> for removing Sb in a microbial electrolysis cell (MEC). Yet, the reduction efficiency of... |
39870289 | Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase. | The mitochondrial flavoenzymes proline dehydrogenase (PRODH) and hydroxyproline dehydrogenase (PRODH2) catalyze the first steps of proline and hydroxyproline catabolism, respectively. The enzymes are targets for chemical probe development because of their roles in cancer cell metabolism (PRODH) and primary hyperoxaluri... |
39870266 | Preparation and characterization of polyvinyl alcohol and chitosan composite film with cassia oil encapsulated in β-cyclodextrin and its application in fresh banana. | In this study, composite films were developed by encapsulating cassia oil (CO) with β-cyclodextrin through a microencapsulation technique and incorporating it into a chitosan (CS), polyvinyl alcohol (PVA) and glycerol matrix. The primary objective of the film was to inhibit bacterial growth on the surface of fresh bana... |
39870230 | The nucleolin antagonist N6L and paclitaxel combination treatment could be a new promising therapeutic strategy for pancreatic ductal adenocarcinoma therapy. | Pancreatic cancer (PCa) is one of the most devastating cancers with few clinical signs and no truly effective therapy. In recent years, our team has demonstrated that nucleolin antagonists such as N6L could be a therapeutic alternative for this disease. In order to study a possible clinic development of N6L (multivalen... |
39870153 | Enhanced nasal-to-brain drug delivery by multivalent bioadhesive nanoparticle clusters for cerebral ischemic reperfusion injury protection. | Following cerebral ischemia, reperfusion injury can worsen ischemia-induced functional, metabolic disturbances, and pathological damage upon blood flow restoration, potentially leading to irreversible harm. Yet, there's a dearth of advanced, localized drug delivery systems ensuring active pharmaceutical ingredient (API... |
39865388 | Pre-folding purification procedures for inclusion body-derived non-tagged cationic recombinant proteins with multiple disulfide bonds for efficient refolding. | The production of disulfide-containing recombinant proteins often requires refolding of inclusion bodies before purification. A pre-refolding purification step is crucial for effective refolding because impurities in the inclusion bodies interfere with refolding and subsequent purification. This study presents a new pr... |
39863862 | Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysis. | <h4>Background</h4>During mammalian spermatogenesis, the cytoskeleton system plays a significant role in morphological changes. Male infertility such as non-obstructive azoospermia (NOA) might be explained by studies of the cytoskeletal system during spermatogenesis.<h4>Methods</h4>The cytoskeleton, scaffold, and actin... |
39863729 | Electrochemical aptasensor for the selective detection of vancomycin based on nanostructured "in-lab" printed electrodes. | A label-free, flexible, and disposable aptasensor was designed for the rapid on-site detection of vancomycin (VAN) levels. The electrochemical sensor was based on lab-printed carbon electrodes (C-PE) enriched with cauliflower-shaped gold nanostructures (AuNSs), on which VAN-specific aptamers were immobilized as bioreco... |
39863689 | Optical band gap modulation in functionalized chitosan biopolymer hybrids using absorption and derivative spectrum fitting methods: A spectroscopic analysis. | In this study, biopolymer composites based on chitosan (CS) with enhanced optical properties were functionalized using Manganese metal complexes and black tea solution dyes. The results indicate that CS with Mn<sup>2+</sup>-complexes can produce polymer hybrids with high absorption, high refractive index and controlled... |
39863666 | The myometrial transcriptome changes in mares with endometrosis. | Mares with endometrosis exhibit histological changes not only in the endometrium but also in the myometrium that suggest possible functional impairment. The molecular background of these changes is not well understood. We hypothesize that the transcriptomic profile of the mare myometrium varies depending on the degree ... |
39863643 | Enhancing power system stability using a TCSC-PIDF controller with innovative multiobjective function and hybrid optimisation logic. | This study aims to establish a thyristor-controlled series compensator (TCSC) equipped with a proportional integral derivative with filter (PIDF) controller by using a futuristic optimisation technique called evolutionary programming sine cosine algorithm (EPSCA) with multiobjective function (MOF). EPSCA is developed b... |
39863620 | Atmospheric air plasma pre-activation and customizable covalent functionalization of PVDF-membranes of microtiter filter plates. | Microtiter-plate-based systems are unified platforms of high-throughput experimentation (HTE). These polymeric devices are used worldwide on a daily basis-mainly in the pharmaceutical industry-for parallel syntheses, reaction optimization, various preclinical studies and high-throughput screening methods. Accordingly, ... |
39863606 | Quasi-vertically asymmetric channels of graphene oxide membrane for ultrafast ion sieving. | The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes, demonstrating potential for highly efficient water desalination and purification, gas and ion separation, and organic ... |
39863599 | Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD. | Autism spectrum disorder (ASD) is linked to ion channel dysfunction, including chloride voltage-gated channel-4 (CLCN4). We generated Clcn4 knockout (KO) mice by deleting exon 5 of chromosome 7 in the C57BL/6 mice. Clcn4 KO exhibited reduced social interaction and increased repetitive behaviors assessed using three-cha... |
39863586 | CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair. | To tolerate oxidative stress, cells enable DNA repair responses often sensitive to poly(ADP-ribose) (PAR) polymerase 1 and 2 (PARP1/2) inhibition-an intervention effective against cancers lacking BRCA1/2. Here, we demonstrate that mutating the CHD6 chromatin remodeler sensitizes cells to PARP1/2 inhibitors in a manner ... |
39863594 | Diversity-oriented synthesis of stereodefined tetrasubstituted alkenes via a modular alkyne gem-addition strategy. | Stereocontrolled construction of tetrasubstituted olefins has been an attractive issue yet remains challenging for synthetic chemists. In this manuscript, alkynyl selenides, when treated with ArBCl<sub>2</sub>, are subject to an exclusive 1,1-carboboration, affording tetrasubstituted alkenes with excellent levels of E-... |
39863571 | Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria. | Pathogenic intracellular bacteria pose a significant threat to global public health due to the barriers presented by host cells hindering the timely detection of hidden bacteria and the effective delivery of therapeutic agents. To address these challenges, we propose a tandem diagnosis-guided treatment paradigm. A supr... |
39863300 | Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study. | <h4>Background</h4>B7 homolog 3 (B7-H3), an overexpressed antigen across multiple solid cancers, represents a promising target for CAR T cell therapy. This study investigated the expression of B7-H3 across various solid tumors and developed novel monoclonal antibodies (mAbs) targeting B7-H3 for CAR T cell therapy.<h4>M... |
39862274 | The activity of indigo carmine against bacteriophages: an edible antiphage agent. | Bacteriophage infections in bacterial cultures pose a significant challenge to industrial bioprocesses, necessitating the development of innovative antiphage solutions. This study explores the antiphage potential of indigo carmine (IC), a common FDA-approved food additive. IC demonstrated selective inactivation of DNA ... |
39862191 | Combining Brillouin Light Scattering Spectroscopy and Machine-Learned Interatomic Potentials to Probe Mechanical Properties of Metal-Organic Frameworks. | The mechanical properties of metal-organic frameworks (MOFs) are of high fundamental and practical relevance. A particularly intriguing technique for determining anisotropic elastic tensors is Brillouin scattering, which so far has rarely been used for highly complex materials like MOFs. In the present contribution, we... |
39862187 | Quantification of Through-Space Intervalence Charge Transfer in Cofacial Thiazolothiazole Metal-Organic Framework and Its Photochromic Behavior. | Electronic coupling between individual redox units in a molecular assembly dictates their charge transfer efficacy. Being a well-defined crystalline structure, the metal-organic framework (MOF) ensures proper positioning of redox-active moieties and provides a unique platform to unveil their charge transfer dynamics an... |
39862164 | All-solid Conductive Elastomers Bridging Mechanical Performance and Sustainability for Durable and Multifunctional Electronics. | The next generation of stretchable electronics seeks to integrate superior mechanical properties with sustainability and sensing stability. Ionically conductive and liquid-free elastomers have gained recognition as promising candidates, addressing the challenges of evaporation and leakage in gel-based conductors. In th... |
39862162 | High-Purity Ethylene Production from Ethane/Ethylene Mixtures at Ambient Conditions by Ethane-Selective Fluorine-Doped Activated Carbon Adsorbents. | Energy-efficient separation of light alkanes from alkenes is considered as one of the most important separations of the chemical industry today due to the high energy penalty associated with the applied conventional cryogenic technologies. This study introduces fluorine-doped activated carbon adsorbents, where elementa... |
39862147 | Recent Development of Nanoparticle Platforms for Organophosphate Nerve Agent Detoxification. | Poisoning by organophosphate (OP) nerve agents remains a pressing global threat due to their extensive use in chemical warfare agents and pesticides, potentially causing high morbidity and mortality worldwide. This urgent need for effective countermeasures has driven considerable interest in innovative detoxification a... |
39862111 | 2024 White Paper on Recent Issues in Bioanalysis: Evolution of Immunogenicity Assessment beyond ADA/NAb; Regulated Genomic/NGS Assays; Hypersensitivity Reactions; Minimum Noise Reduction; False Positive Range; Modernized Vaccine Approaches; NAb/TAb Correlation <u>(PART 3A</u> - Recommendations on Advanced S... | The 18<sup>th</sup> Workshop on Recent Issues in Bioanalysis (18<sup>th</sup> WRIB) took place in San Antonio, TX, USA on May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest in bioanalysis.... |
39828209 | Smart core-shell microneedles for psoriasis therapy: In situ self-assembly of calcium ion-coordinated dexamethasone hydrogel. | Psoriasis is a prevalent relapsing dermatological condition that often necessitates lifelong treatment. The distinctive thickening of the stratum corneum presents a challenge to drug penetration. The employment of microneedles has been demonstrated to enhance the transdermal drug delivery efficacy by creating multiple ... |
40510294 | Lipopeptide Hydrogel Possesses Adjuvant-Like Properties for the Delivery of the GPC-3 Peptide-derived Antigen. | Peptide-based cancer vaccines are attractive as they can elicit antigen-specific cytotoxic T lymphocytes (CTLs) with minimal side effects. However, low immunogenic responses have delayed their translation to the clinic. Adjuvants, which are required in vaccines to boost immunogenicity, currently lack the ability to sim... |
40276581 | Multifunctional metal-organic frameworks as promising nanomaterials for antimicrobial strategies. | Bacterial infections pose a serious threat to human health. While antibiotics have been effective in treating bacterial infectious diseases, antibiotic resistance significantly reduces their effectiveness. Therefore, it is crucial to develop new and effective antimicrobial strategies. Metal-organic frameworks (MOFs) ha... |
40177295 | Porous covalent organic framework liquid for boosting CO<sub>2</sub> adsorption and catalysis via dynamically expanding effect. | The features of intrinsic porosity and fluidity endow porous liquids (PLs) with unique properties and performance but the preparation of PLs remains challenging due to the difficulty in liquefying and keeping porous features at the same time. Herein, we develop a stepwise surface functionalization and ion exchange stra... |
40028552 | 3D-printed and In-situ prepared hydrogel anti-bacterial wound patch with silver nanoparticle embedded matrix. | The application of wearable hydrogel wound patches has great potential in advancing the field of medicine. However, for high reach and large-scale utilization, the fabrication process of wearable hydrogel wound patches needs to be low-cost, reliable, and have high throughput. Therefore, the incorporation of 3D-printing... |
40006920 | Immunogenic Potential of Selected Peptides from SARS-CoV-2 Proteins and Their Ability to Block S1/ACE-2 Binding. | The first infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease 2019 (COVID-19), occurred in December 2019. Within a single month, the disease reached other countries, spreading in a rapid and generalized manner worldwide to cause the COVID-19 pandemi... |
40006524 | Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge. | <b>Background/Objectives:</b> Transforming Growth Factor-beta (<i>TGFβ1</i>) plays a core role in the process of pulmonary fibrosis (PF). The progression of pulmonary fibrosis can be alleviated by siRNA-based inhibiting <i>TGF-β1</i>. However, the limitations of naked siRNA lead to the failure of achieving therapeutic ... |
40005968 | Potential Applications of Rare Earth Metal Nanoparticles in Biomedicine. | In recent years, the world scientific community has shown increasing interest in rare earth metals in general and their nanoparticles in particular. Medicine and pharmaceuticals are no exception in this matter. In this review, we have considered the main opportunities and potential applications of rare earth metal (gad... |
40005620 | SARS-CoV-2 XEC: A Genome-Based Survey. | Recombination, a process of genetic exchange between distinct organisms, has played a critical role in the emergence of SARS-CoV-2 variants such as the XEC recombinant. This study provides a detailed genomic and structural characterization of XEC, derived from the recombination of lineages KP.3.3 (donor) and KS.1.1 (ac... |
39996224 | Carcinoid Heart Disease: A Classic One, But Not Always Remembered. | A 24-year-old female presented a dermatosis characterized by confluent erythematous spots on her face and neck and was diagnosed with presumed systemic lupus erythematosus. Five years later, she was admitted to our Cardiology Department due to symptoms of right heart failure (fatigue, dyspnea, edema in inferior limbs, ... |
39982223 | In Vitro Functional Validation of an Anti-FREM2 Nanobody for Glioblastoma Cell Targeting. | <b>Background/Objectives</b>: Glioblastomas are the most common brain malignancies. Despite the implementation of multimodal therapy, patient life expectancy after diagnosis is barely 12 to 18 months. Glioblastomas are highly heterogeneous at the genetic and epigenetic level and comprise multiple different cell subpopu... |
39974646 | Nanoparticle-Mediated mRNA Delivery to Triple-Negative Breast Cancer (TNBC) Patient-Derived Xenograft (PDX) Tumors. | mRNA-based therapies can overcome several challenges faced by traditional therapies in treating a variety of diseases by selectively modulating genes and proteins without genomic integration. However, due to mRNA's poor stability and inherent limitations, nanoparticle (NP) platforms have been developed to deliver funct... |
39944924 | Synergistic anticancer effects of mitochondria-targeting peptide combined with paclitaxel in breast cancer cells: a preclinical study. | <h4>Purpose</h4>Mitochondria-accumulating amphiphilic peptide (Mito-FF) was designed to selectively target mitochondria in cancer cells and enhance anticancer effects through its unique structure. Mito-FF consists of (1) diphenylalanine, a β-sheet-forming building block critical for self-assembly; (2) triphenylphosphon... |
39942912 | Multiprotein Complexes of Plant Glycosyltransferases Involved in Their Function and Trafficking. | Plant cells utilize protein oligomerization for their functions in numerous important cellular processes. Protein-protein interactions are necessary to stabilize, optimize, and activate enzymes, as well as localize proteins to specific organelles and membranes. Glycosyltransferases-enzymes that attach sugars to polysac... |
39942646 | CRISPR-Cas9 Gene Therapy: Non-Viral Delivery and Stimuli-Responsive Nanoformulations. | The CRISPR-Cas9 technology, one of the groundbreaking genome editing methods for addressing genetic disorders, has emerged as a powerful, precise, and efficient tool. However, its clinical translation remains hindered by challenges in delivery efficiency and targeting specificity. This review provides a comprehensive a... |
39942642 | Effect of Amino Acid, Sugar, Ca<sup>2+</sup>, and Mg<sup>2+</sup> on Maillard Reaction-Associated Products in Modified Sparkling Base Wines During Accelerated Aging. | The Maillard reaction (MR) between sugars and amino acids, peptides, or proteins is understood to occur gradually during the production and aging of sparkling wines, where it contributes to caramel, roasted, and toasted aromas. Divalent metal ions can accelerate the MR, although this has not been previously reported in... |
39942632 | Construction of Hydrogen-Bonded Self-Assembled Structures of Sodium 4-[(4-Chlorobenzoyl) Amino] Benzoate for Dispersion and Lubrication in Polypropylene. | Among numerous nucleating agents, organic carboxylate nucleating agents have been demonstrated to markedly improve the crystallization of polypropylene (PP). However, poor dispersion in the PP matrix affects the modification effect. In this work, erucamide (ECM) and sodium 4-[(4-chlorobenzoyl) amino] benzoate (SCAB) fo... |
39942629 | Application of a Strong Base Anion Exchange Resin for the Removal of Thiophenol from Aqueous Solution. | Thiophenol (synonyms: phenyl mercaptan, benzenethiol) may appear in the aquatic environment as a result of human activity. It is used as a raw material in organic synthesis in various industries for the production of dyes, pesticides, pharmaceuticals and polymers, such as polyphenylene sulfide (PPS). It may also enter ... |
39942628 | Kinetic and Structural Insights into β-Cyclodextrin Complexation with Asparagine Enantiomers: An Experimental and Theoretical Study. | We report on the dynamic interactions between β-cyclodextrin (β-CD) and each one of the two enantiomers of asparagine (d-Asp, l-Asp). Molecular docking methodologies were applied to elucidate the formation of the β-CD-d-Asp and β-CD-l-Asp inclusion complexes. Ultrasonic relaxation spectra revealed a single relaxation p... |
39941978 | Ultrasound-Assisted Determination of Selenium in Organic Rice Using Deep Eutectic Solvents Coupled with Inductively Coupled Plasma Mass Spectrometry. | As the focus on green chemistry intensifies, researchers are progressively looking to incorporate biodegradable and environmentally friendly solvents. Given the prevalent use of inorganic solvents in conventional methods for detecting selenium content, this study utilized a mixture design approach to create four deep e... |
39941760 | Hepatic Iron Overload and Hepatocellular Carcinoma: New Insights into Pathophysiological Mechanisms and Therapeutic Approaches. | Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is rising in global incidence and mortality. Metabolic dysfunction-associated steatotic liver disease (MASLD), one of the leading causes of chronic liver disease, is strongly linked to metabolic conditions that can progress to liver cirrhosis... |
39940748 | A Practical Guide to Computational Tools for Engineering Biocatalytic Properties. | The growing demand for efficient, selective, and stable enzymes has fueled advancements in computational enzyme engineering, a field that complements experimental methods to accelerate enzyme discovery. With a plethora of software and tools available, researchers from different disciplines often face challenges in sele... |
39940522 | A Comparative Study on the Structural, Physicochemical, Release, and Antioxidant Properties of Sodium Casein and Gelatin Films Containing Sea Buckthorn Oil. | The aim of this study was to compare the effect of increasing concentrations (0, 1, 2, 4%) of sea buckthorn oil (SBO) on the structural, physicochemical, release, and antioxidant properties of glycerol-plasticized sodium casein (NaCAS) and gelatin (GEL) films. Ultrasonic treatment ensured effective homogenization of SB... |
39940157 | Complex Refractive Index Spectrum of CsPbBr<sub>3</sub> Nanocrystals via the Effective Medium Approximation. | We have estimated the intrinsic complex refractive index spectrum of a CsPbBr<sub>3</sub> nanocrystal. With various dilute solutions of CsPbBr<sub>3</sub> nanocrystals dissolved in toluene, effective refractive indices were measured at two different wavelengths using Michelson interferometry. Given the effective absorp... |
39940159 | A Multi-Method Approach to Analyzing MOFs for Chemical Warfare Simulant Capture: Molecular Simulation, Machine Learning, and Molecular Fingerprints. | Mustard gas (HD) is a well-known chemical warfare agent, recognized for its extreme toxicity and severe hazards. Metal-organic frameworks (MOFs), with their unique structural properties, show significant potential for HD adsorption applications. Due to the extreme hazards of HD, most experimental studies focus on its s... |
39936975 | Lysosome Functions in Atherosclerosis: A Potential Therapeutic Target. | Lysosomes in mammalian cells are recognized as key digestive organelles, containing a variety of hydrolytic enzymes that enable the processing of both endogenous and exogenous substrates. These organelles digest various macromolecules and recycle them through the autophagy-lysosomal system. Recent research has expanded... |
39936969 | Analysis of Exon Skipping Applicability for Dysferlinopathies. | Exon skipping, mediated through antisense oligonucleotides (ASOs), is a promising approach to exclude pathogenic variants from the <i>DYSF</i> gene and treat dysferlinopathies. Understanding the applicability of various exon skipping strategies in the total patient population, an analysis not previously performed, can ... |
39935894 | A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines. | Bromodomain-containing protein 4 <b>(</b>BRD4<b>)</b> is a key protein that drives the development of malignant melanoma and is closely associated with the ferroptosis signaling pathway. Degradation of BRD4 can downregulate the expression of ferroptosis-related genes such as GPX4, thereby promoting tumor-specific ferro... |
39935892 | Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing. | The high mortality risk of burn infected wounds has dictated the clinical need for the development of new biomaterials that can regulate multiple aspects of the healing process in a high-quality manner. Although nanozymes have made progress in inflammation modulation and antibacterial management, they often lack the ab... |
39927265 | Isolation, characterization and liposome-loaded encapsulation of a novel virulent <i>Salmonella</i> phage vB-SeS-01. | <h4>Introduction</h4><i>Salmonella</i> is a common foodborne pathogenic bacterium, displaying facultative intracellular parasitic behavior, which can help the escape against antibiotics treatment. Bacteriophages have the potential to control both intracellular and facultative intracellular bacteria and can be developed... |
39926546 | Mussel-Inspired <i>In Situ</i> Photodynamic Antibacterial Coating for Postoperative Management of Artificial Corneas. | Artificial corneal (AC) implants offer hope to millions with corneal blindness, including 5 million in China. Titanium is one of the materials commonly used in the fabrication of artificial corneal scaffolders because of its light texture, high mechanical properties, and high biosafety. However, postoperative bacterial... |
39926530 | Insights into Novel Arylazopyrazolo[1,5-<i>a</i>]pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation, and Molecular Docking. | MurA is a pivotal target in antimicrobial therapy owing to its fundamental function in bacterial cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial lysis, but also presents a promising strategy to combat the growing threat of antibiotic resistance by providing an effecti... |
39926486 | Development and Application of Fe<sup>3+</sup>, Al<sup>3+</sup>, Cr<sup>3+</sup> Dummy Atom Models for Metal-Organic Frameworks. | Various metal-organic frameworks (MOFs) containing trivalent cations (such as Fe<sup>3+</sup>, Al<sup>3+</sup>, and Cr<sup>3+</sup>) have been reported and have shown great potential in applications. However, the high structural diversity and strong electronic interactions between metal centers and their ligands make t... |
39925843 | Recent advances in polymeric nanoparticles for the treatment of hepatic diseases. | The liver performs crucial roles in energy metabolism, detoxification, and immune regulation. Hepatic diseases, including hepatitis, liver fibrosis, and liver cancer, have posed a significant threat to global health, emphasizing the critical need for the development of novel and effective treatment approaches. Nanotech... |
39925808 | From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments. | Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, among which 82% arise from actinic keratosis (AK) characterized by lesions of epidermal keratinocyte dysplasia. It is of great significance to uncover the progression mechanisms from AK to cSCC, which will facilitate the early ... |
39925807 | The success of the tumor immunotherapy: neutrophils from bench to beside. | The present immune therapy was focused on the immune checkpoint blockade or Chimeric Antigen Receptor T-Cell Immunotherapy (CART) transfer, but how to activate the innate immune system to antitumor still lags out. Neutrophils are the most abundant circulating leukocytes in human, and heterogeneous neutrophils have been... |
39925799 | Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish. | <h4>Introduction</h4>Ochratoxin A (OTA) is a toxic secondary metabolite produced by Aspergillus and Penicillium species, posing a significant threat to global food safety. Previous studies have demonstrated the diverse toxic effects of OTA, including hepatotoxicity, nephrotoxicity, and carcinogenicity. However, limited... |
39925738 | Non-histone lactylation: unveiling its functional significance. | Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on non-histone proteins. Recently, high-throughput proteomics studies... |
39925734 | Discovery of potent measles virus fusion inhibitor peptides <i>via</i> structure-guided derivatization. | Fusion inhibitor peptide (FIP), a short peptide known as a measles virus (MeV) infection inhibitor, inhibits membrane fusion between the viral envelope of MeV and the host cell membrane. Therefore, FIP is potentially useful as a drug candidate for treating MeV infection, but improvement of inhibitory activity is desira... |
39916888 | Strengthened d-p orbital hybridization and hydrogen diffusion in a hollow N-doped porous carbon/Ru cluster catalyst system for hydrogen evolution reactions. | Developing advanced catalysts with rapid hydrogen evolution reaction (HER) kinetics in alkaline media is vital for hydrogen production. Through the d-p orbital hybridization effect, the electronic structure and H* adsorption can be optimized on metal species. Herein, a N-doped hollow carbon (H-NPC)-supported Ru cluster... |
39906386 | Unifying principles for the design and evaluation of natural product-inspired compound collections. | Natural products play a major role in the discovery of novel bioactive compounds. In this regard, the synthesis of natural product-inspired and -derived analogues is an active field that is further developing. Several strategies and principles for the design of such compounds have been developed to streamline their acc... |
39906332 | A practical DNA data storage using an expanded alphabet introducing 5-methylcytosine. | The DNA molecule is a promising next-generation data storage medium. Recently, it has been theoretically proposed that non-natural or modified bases can serve as extra molecular letters to increase the information density. However, this strategy is challenging due to the difficulty in synthesizing non-natural DNA seque... |
39901714 | Impact of stocking densities on growth, organ index, serum biochemistry, gut morphology and microbiota of young ducks in a rice-duck-crayfish coculture system. | <h4>Objective</h4>The rice-duck-crayfish (RDC) coculture system, an ecologically efficient breeding strategy that accommodates natural behavior of ducks and improves their welfare. The optimal stocking density and its impact on duck health in this system remains undetermined. The study examined the impact of stocking d... |
39879845 | Exploring the effect of Zr/B ratio on the stability and reactivity of activated ε-caprolactone complexes: A DFT, QTAIM and NCI study. | Monomer insertion, leading to the formation of an activated monomer complex, is a critical step in cationic ring-opening polymerization (CROP) of cyclic monomers, such as ε-caprolactone (CL). In this study, Density Functional Theory (DFT) calculations were employed to investigate the structural and electronic propertie... |
39879751 | Preparation of photodynamic-controlled release packaging for pork preservation and its visualization. | The current study aimed to synthesize a ZIF-8 metal-organic framework loaded with the Rose Bengal (ZIF-8@RB) as the photodynamic sterilization ingredient to address the uncontrolled release of active ingredients in packaging films. The photodynamic controlled release packaging film was then prepared using a PVDF polyme... |
39877588 | Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide. | <h4>Purpose</h4>Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Oxaliplatin (OXA) is currently the primary chemotherapeutic agent for CRC, but its efficacy is limited by the tumor microenvironment (TME). Here, we present a combined approach of chemotherapy and TME modulation for ... |
39874828 | Mn-doped MOF nanoparticles mitigating hypoxia via in-situ substitution strategy for dual-imaging guided combination treatment of microwave dynamic therapy and chemotherapy. | Microwave dynamic therapy (MWDT) destroy tumor cells using reactive oxygen species (ROS), but its effectiveness is limited by low ROS production and intracellular oxygen (O<sub>2</sub>) availability. This study presents a novel strategy using manganese (II) ion (Mn<sup>2+</sup>) doped iron (Fe)-based metal-organic fram... |
39872292 | Molecular imaging of viral pathogenesis and opportunities for the future. | Molecular imaging is used in clinical and research settings. Since tools to study viral pathogenesis longitudinally and systemically are limited, molecular imaging is an attractive and largely unexplored tool. This review discusses molecular imaging probes and techniques for studying viruses, particularly those current... |
39867956 | A critical appraisal of advances in integrated CO<sub>2</sub> capture and electrochemical conversion. | This perspective work examines the current advancements in integrated CO<sub>2</sub> capture and electrochemical conversion technologies, comparing the emerging methods of (1) electrochemical reactive capture (eRCC) though amine- and (bi)carbonate-mediated processes and (2) direct (flue gas) adsorptive capture and conv... |
39867334 | Progress in research on organic photovoltaic acceptor materials. | In the past two decades, organic solar cells (OSCs) have begun to attract attention as the efficiency of inorganic solar cells gradually approaches the theoretical limit. In the early development stage of OSCs, p-type conjugated polymers and n-type fullerene derivatives were the most commonly used electron donors and a... |
39867322 | Nanosized MCM-41 silica from rice husk and its application for the removal of organic dyes from water. | A novel synthesis of a nanometric MCM-41 from biogenic silica obtained from rice husk is here presented. CTABr and Pluronic F127 surfactants were employed as templating agents to promote the formation of a long-range ordered 2D-hexagonal structure with cylindrical pores and to limit the particle growth at the nanoscale... |
39867318 | Cu/Cu<sub>2</sub>O/NH<sub>2</sub>-MIL-88B (Fe) heterojunction as the photocatalyst to remove hexavalent chromium heavy metal ions in water. | This work aimed at addressing the problem of hexavalent chromium pollution in the water environment, designing and preparing the Cu/Cu<sub>2</sub>O/NH<sub>2</sub>-MIL-88B (Fe) heterojunction material with NH<sub>2</sub>-MIL-88B (Fe) as the carrier, Cu/Cu<sub>2</sub>O was loaded on NH<sub>2</sub>-MIL-88B (Fe) by light-a... |
39866964 | Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head. | Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. While MRI is a highly... |
39864761 | Protective effect of curcumin-loaded zeolitic imidazolate framework-8-based pH-responsive drug delivery system against Staphylococcus aureus infection. | Mastitis, generally caused by pathogenic microorganisms, is a serious disease in dairy farming. Staphylococcus aureus (S. aureus) is one of the main pathogens that induces mastitis in dairy cows. It evades the innate and adaptive immune responses of dairy cows, causing recessive transmission and harming the health of t... |
39864699 | Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release. | Pathogen invasion and persistent inflammatory storms caused by bacterial infections are the main challenges to the healing of infected wounds. Herein, this study proposed a pH-responsive polysaccharide hydrogel dressing (CG-HA) composed of cationic guar gum (CG) and hyaluronic acid (HA). Additionally, Zn<sup>2+</sup> a... |
39864681 | Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic stearic acid-grafted inulin: Preparation, characterization, and functional evaluation. | The clinical application of curcumin (CUR) is restricted by its low solubility, instability, and poor bioavailability. To overcome these limitations, we developed a novel stearic acid-grafted inulin-based nano-delivery system for CUR encapsulation. The structure of stearoyl inulin (SA-IN) was characterized using Fourie... |
39864625 | A quantitative intracellular peptide-binding assay reveals recognition determinants and context dependence of short linear motifs. | Transient protein-protein interactions play key roles in controlling dynamic cellular responses. Many examples involve globular protein domains that bind to peptide sequences known as short linear motifs (SLiMs), which are enriched in intrinsically disordered regions of proteins. Here we describe a novel functional ass... |
39864624 | Extremophilic hemoglobins: The structure of Shewanella benthica truncated hemoglobin N. | Truncated hemoglobins (TrHbs) have an ancient origin and are widely distributed in microorganisms where they often serve roles other than dioxygen transport and storage. In extremophiles, these small heme proteins must have features that secure function under challenging conditions: at minimum, they must be folded, ret... |
39862805 | Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolution. | <h4>Background</h4>The widespread and evolution of RNA viruses, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights the importance of fast identification of virus subtypes, particularly in non-laboratory settings. Rapid and inexpensive at-home testing of viral nucleic acids with single-... |
39856746 | Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants. | Passive antibody therapies, typically administered via parenteral routes, have played a crucial role in the initial response to the COVID-19 pandemic. However, the ongoing evolution of SARS-CoV-2 has revealed significant limitations of this approach, primarily due to mutational escape and the inadequate delivery of ant... |
39856392 | Expanding the frontiers of electrocatalysis: advanced theoretical methods for water splitting. | Electrochemical water splitting, which encompasses the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER), offers a promising route for sustainable hydrogen production. The development of efficient and cost-effective electrocatalysts is crucial for advancing this technology, especially given the ... |
39856386 | Structural model of a bacterial focal adhesion complex. | Cell movement on surfaces relies on focal adhesion complexes (FAs), which connect cytoskeletal motors to the extracellular matrix to produce traction forces. The soil bacterium Myxococcus xanthus uses a bacterial FA (bFA), for surface movement and predation. The bFA system, known as Agl-Glt, is a complex network of at ... |
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