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39916954 | A new paradigm for cancer immunotherapy: targeting immunogenic cell death-related noncoding RNA. | Cancer immunotherapy has shown significant potential in treating several malignancies by stimulating the host immune system to recognize and attack cancer cells. Immunogenic cell death (ICD) can amplify the antitumor immune responses and reverse the immunosuppressive tumor microenvironment, thus increasing the sensitiv... |
39916883 | Universal synthesis of single-atom electrocatalysts <i>via in situ</i> fluoride ion etching for hydrogen evolution. | Single-atom catalysts (SACs) have attracted considerable interest in the field of electrocatalysis due to their high efficiency of metal utilization and catalytic activity. However, traditional methods of SACs fabrication are often complex and time-consuming. Herein, F-Ru@TiO <sub><i>x</i></sub> N <sub><i>y</i></sub> w... |
39916860 | Predatory bacteria can intensify lung-injury in a multidrug-resistant <i>Acinetobacter baumannii</i> pneumonia model in rat. | <h4>Introduction</h4>Respiratory tract infection caused by antibiotic-resistant bacteria are one of the most important causes of death worldwide. Therefore, in this study, we investigated the possibility of using predatory bacteria to improve the <i>Acinetobacter baumannii</i> pneumonia model in rat.<h4>Methods</h4>Mul... |
39906646 | Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and In situ remineralization properties for dental caries prevention. | Dental caries is primarily caused by cariogenic bacteria metabolizing carbohydrates to produce acidic substances that erode the dental hard tissues. Traditional remineralization treatments often have limited efficacy due to their lack of antibacterial activity. According to the Interrupting Dental Caries (IDC) theory, ... |
39906313 | The physics-AI dialogue in drug design. | A long path has led from the determination of the first protein structure in 1960 to the recent breakthroughs in protein science. Protein structure prediction and design methodologies based on machine learning (ML) have been recognized with the 2024 Nobel prize in Chemistry, but they would not have been possible withou... |
39897407 | Biochemical characterization and discovery of inhibitors for <i>Pf</i>Sir2A: new tricks for an old enzyme. | The Sir2 enzyme from <i>Plasmodium falciparum</i> (<i>Pf</i>Sir2A) is essential for the antigenic variation of this parasite, and its inhibition is expected to have therapeutic effects for malaria. Selective <i>Pf</i>Sir2A inhibitors are not available yet, partially due to the fact that this enzyme demonstrates extreme... |
39889681 | Tailoring SERS sensitivity in AgNWs-ZIF-67 substrates: Effects of MOF thickness and probe-pore size matching. | In this study, we develop a filter paper-supported Ag nanowire (AgNWs) substrate coated with a tunable layer of zeolitic imidazolate framework-67 (ZIF-67) metal-organic framework (MOF) for surface-enhanced Raman scattering (SERS) applications. The thickness of the ZIF-67 layer is precisely controlled by adjusting the s... |
39884131 | Anti-neuroinflammatory agent rhein lysinate-based self-assembled injectable hydrogel loaded with ZL006 for promoting post-stroke functional recovery. | The therapeutic agent-based self-assembled hydrogel is gaining interest for biomedical applications, because it overcomes the poor biodegradability and low therapeutic agent loading of conventional polymer gelator-based hydrogel. Here, we present rhein lysinate (RHL), a therapeutic agent that self-assembles to form a s... |
39874866 | Has the documentation of chest injuries and the development of systemic complications in patients with long bone fractures changed over time?-A systematic literature review and meta-analysis by the IMPACT expert group. | <h4>Introduction</h4>Blunt chest trauma represents a major risk factor for complications in polytrauma patients. Various scoring systems have emerged, but their impact is not fully appreciated. This review evaluates changes in chest trauma scoring over time and potential shifts in complication rates linked to modified ... |
39870027 | Advanced cortisol detection: A cMWCNTs-enhanced MB@Zr-MOF ratiometric electrochemical aptasensor. | A ratiometric electrochemical aptasensor was developed for ultra-sensitive detection of cortisol using aptamer (Apt) as recognition element, methylene blue (MB) as signal probe, and zirconium metal-organic framework (Zr-MOF) as carrier loaded with abundant MB for signal amplification. The carboxylated multi-walled carb... |
39870023 | Rational design of AIEgens through π-bridge engineering for dual-modal photodynamic and photothermal therapy. | A series of aggregation-induced emission luminogens (AIEgens) with donor-π-acceptor (D-π-A) architecture were rationally designed and synthesized through π-bridge engineering for dual-modal photodynamic and photothermal therapy. The AIEgens (TPT, TFT, and TTT) were constructed using methoxy-substituted tetraphenylene a... |
39869993 | Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements. | Sound-evoked displacement responses at the outer hair cell-Deiters' cell junction (OHC-DC) are of significant interest in cochlear mechanics, as OHCs are believed to be in part responsible for active tuning enhancement and amplification. Motion in the cochlea is three-dimensional, and the architecture of the organ of C... |
39867321 | Advancements in drug discovery: integrating CADD tools and drug repurposing for PD-1/PD-L1 axis inhibition. | Despite significant strides in improving cancer survival rates, the global cancer burden remains substantial, with an anticipated rise in new cases. Immune checkpoints, key regulators of immune responses, play a crucial role in cancer evasion mechanisms. The discovery of immune checkpoint inhibitors (ICIs) targeting PD... |
39864174 | Mechanisms of epigallocatechin-3-gallate-loaded metal-organic framework in preventing oxidative degradation of shrimp (Litopenaeus vannamei) surimi gel. | This work aimed to elucidate the deterioration mechanisms of shrimp surimi gels during refrigerated storage, and the regulatory mechanisms of epigallocatechin-3-gallate loaded cyclodextrin-based metal-organic framework (EGCG@CD-MOF) as a model antioxidant. Labele-free proteomics provided a quantitative analysis of the ... |
39864120 | Development and characterization of farnesol complexed in β- and hydroxypropyl-β-cyclodextrin and their antibacterial activity. | Farnesol (FAR) belongs to terpenes group and is a sesquiterpene alcohol and a hydrophobic compound, which can be extracted from natural sources or obtained by organic chemical or biological synthesis. Recent advances in the field of nanotechnology allow the drawbacks of low drug solubility, which can improve the drug t... |
39863208 | Enhanced electrical conductivity and antibacterial properties of bacterial cellulose composite membrane decorated with hydroxypropyl-β-cyclodextrin/magnetic particle/alpha-lipoic acid/nano silver. | The electrical conductivity and antibacterial properties are crucial characteristics for bacterial cellulose (BC) based membranes to be broadly applied in the field of wearable electronics. In the study, to achieve these aims, alpha-lipoic acid (LA) was utilized as anchoring groups and reducing agent, hydroxypropyl-β-c... |
39863194 | Hyaluronic acid modified metal-organic frameworks loading cisplatin achieve combined chemodynamic therapy and chemotherapy for lung cancer. | As one of the most commonly used chemotherapeutic agents in clinical practice, cisplatin is unable to selectively accumulate in tumor tissue due to its lack of targeting ability, leading to increased systemic toxicities. Additionally, the effectiveness of monotherapy is greatly limited. Therefore, the development of ne... |
39863148 | Self-assembled aptamer nanoparticles for enhanced recognition and anticancer therapy through a lysosome-independent pathway. | Aptamers and aptamer-drug conjugates (ApDCs) have shown some success as targeted therapies in cancer theranostics. However, their stability in complex media and their capacity to evade lysosomal breakdown still need improvement. To address these challenges, we herein developed a one-step self-assembly strategy to impro... |
39862904 | Self-organization from organs to embryoids by activin in early amphibian development. | Embryonic development is a complex self-organizing process orchestrated by a series of regulatory events at the molecular and cellular levels, resulting in the formation of a fully functional organism. This review focuses on activin protein as a mesoderm-inducing factor and the self-organizing properties it confers. Ac... |
39861946 | Two pathogen-inducible UDP-glycosyltransferases, UGT73C3 and UGT73C4, catalyze the glycosylation of pinoresinol to promote plant immunity in Arabidopsis. | UDP-glycosyltransferases (UGTs) constitute the largest glycosyltransferase family in the plant kingdom, regulating many metabolic processes by transferring sugar moieties onto various small molecules. However, their physiological significance in plants remains largely unknown. Here, we reveal the functions and mechanis... |
39855283 | Ternary complex of Kaempferol-Hydroxypropyl-β-Cyclodextrin-Liposomes against hepatocellular carcinoma: Preparation, validation, pharmacokinetics and efficacy studies. | Kaempferol (KP), a GRAS-certified phytomolecule enrolled in Phase I trials, is reported with various biological effects including anticancer activity. However, its poor pharmacokinetic profile limits the translational utility. Studies indicate that liposomes incorporating cyclodextrin inclusion complexes improves the b... |
39850087 | Carbon dots with red emission as nanoprobe for sensing of heparin in biofluids and pharmaceutical samples. | Heparin (HEP) is one of the oldest anticoagulant drugs, widely used in clinical settings, particularly in surgery and dialysis machines. Despite its long history, it remains extensively employed in medical practice. This study introduces a selective and cost-effective method for the rapid detection of HEP using red-emi... |
39850085 | Optimizing adsorption and photocatalysis for tetracycline and sulfamethoxazole removal: the role of Ag<sup>+</sup> and NH<sub>4</sub> <sup>+</sup> in Bi-MOF derivatives. | This study focuses on the synthesis, characterization, and evaluation of the photocatalytic efficiency of bismuth-based metal-organic frameworks (Bi-MOFs) and their derivatives, specifically Ag<sup>+</sup>/Bi-MOF and NH<sub>4</sub> <sup>+</sup>/Ag<sup>+</sup>/Bi-MOF, in the degradation of tetracycline (TC) and sulfamet... |
39849842 | Convergent evolution in angiosperms adapted to cold climates. | Convergent and parallel evolution occur more frequently than previously thought. Here, we focus on the evolutionary adaptations of angiosperms at sub-zero temperatures. We begin by introducing the history of research on convergent and parallel evolution, defining all independent similarities as convergent evolution. Ou... |
39849657 | Helicobacter pylori and gastric cancer: mechanisms and new perspectives. | Gastric cancer remains a significant global health challenge, with Helicobacter pylori (H. pylori) recognized as a major etiological agent, affecting an estimated 50% of the world's population. There has been a rapidly expanding knowledge of the molecular and pathogenetic mechanisms of H. pylori over the decades. This ... |
39849570 | Mesenchymal stromal cell exosomes for drug delivery of prostate cancer treatments: a review. | Interest in prostate cancer as a research topic has gradually increased. As a result, a series of innovative treatment strategies have emerged with an in-depth understanding of the disease. Owing to their unique biological characteristics, mesenchymal stromal cell exosomes (MSC-Exos) have garnered significant attention... |
39849558 | Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms. | The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the absence of precision in pathogen... |
39849529 | Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions. | α-Synucleinopathies constitute a spectrum of neurodegenerative disorders, including Parkinson's disease (PD), Lewy body dementia (LBD), Multiple System Atrophy (MSA), and Alzheimer's disease concurrent with LBD (AD-LBD). These disorders are unified by a pathological hallmark: aberrant misfolding and accumulation of α-s... |
39849517 | Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori). | <h4>Background</h4>Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and impact on living organisms. However, little is known about their interactions in terrestrial e... |
39849460 | New insights into the structure domain and function of NLR family CARD domain containing 5. | NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization domain (NOD or NACHT), and a ... |
39849458 | Optimization of chemical transfection in airway epithelial cell lines. | <h4>Background</h4>Chemical transfection is a widely employed technique in airway epithelium research, enabling the study of gene expression changes and effects. Additionally, it has been explored for its potential application in delivering gene therapies. Here, we characterize the transfection efficiency of EX-EGFP-Lv... |
39849298 | Imidazole Cationic-Bridged Pillar[5]arene Polymer as a Recycle Adsorbent for Iodine Capture. | Developing efficient and recyclable iodine adsorbents is crucial for addressing radioactive iodine pollution. An imidazole cation-bridged pillar[5]arene polymer (P5-P5I) was synthesized via a salt formation reaction. P5-P5I exhibited a high iodine vapor capture capacity of 2130.0 mg/g and a maximum adsorption capacity ... |
39849286 | Construction of a thermosensitive gel based on hydroxypropyl-β-cyclodextrin/meloxicam inclusion complexes for improving meloxicam solubility and prolonging drug retention time in the cornea. | The eyes are easily stimulated by external factors, which can cause inflammation. Anti-inflammatory drugs are usually used to inhibit the production of inflammatory factors. Many nonsteroidal anti-inflammatory drugs have been used for the eye, but due to the poor solubility of meloxicam, there are currently no marketed... |
39849109 | A living library concept to capture the dynamics and reactivity of mixed-metal clusters for catalysis. | The exploration of ligated metal clusters' chemical space is challenging, partly owing to an insufficiently targeted access to reactive clusters. Now, dynamic mixtures of clusters, defined as living libraries, are obtained through organometallic precursor chemistry. The libraries are populated with interrelated cluster... |
39849085 | KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid. | Examples of long-range gene regulation in bacteria are rare and generally thought to involve DNA looping. Here, using a combination of biophysical approaches including X-ray crystallography and single-molecule analysis for the KorB-KorA system in Escherichia coli, we show that long-range gene silencing on the plasmid R... |
39849060 | The association of gut microbiota, immunocyte dynamics, and protein-protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis. | This study focused on the relationships among gut microbiota, plasma protein ratios, and tuberculosis. Given the unclear causal relationship between gut microbiota and tuberculosis and the scarcity of research on relevant plasma protein ratios in tuberculosis, Mendelian randomization analysis (MR) was employed for in-d... |
39849005 | Enhancing the performance of polyfarnesene-based bio-rubbers with surface-modified cellulose nanocrystals and nanofibers. | As the rubber industry seeks sustainable alternatives to mitigate its environmental impact, this study introduces a biobased approach using polyfarnesene rubber reinforced with plasma-modified cellulose nanocrystals (MCNC) and nanofibers (MCNF). The nanocellulose was modified by plasma-induced polymerization using tran... |
39848784 | Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy. | Phytochemicals are typically natural bioactive compounds or metabolites produced by plants. Phytochemical-loaded nanocarrier systems, designed to overcome bioavailability limitations and enhance therapeutic effects, have garnered significant attention in recent years. The coronavirus disease 2019 (COVID-19) pandemic ha... |
39848693 | Biomimetic Nanostructure Engineering of Ultralow Ir-Loading Electrocatalysts for Oxygen Reduction Reaction. | Promoting the rate of the oxygen reduction reaction (ORR) is critical for boosting the overall energy efficiency of the flexible zinc-air batteries (FZABs). Inspired by nature, we designed "branch-leaf" like hierarchical porous carbon nanofibers with ultralow loadings of Ir nanoparticles (NPs) derived from covalent-org... |
39848625 | Ultrathin 2D Cu-Porphyrin MOF Nanosheet Loaded Fe<sub>3</sub>O<sub>4</sub> Nanoparticles As a Multifunctional Nanoplatform for Synergetic Chemodynamic and Photodynamic Therapy Independent of O<sub>2</sub>. | In this study, we developed a multifunctional nanoplatform to address the limitations of strictly acidic pH for the Fenton reaction involving Fe<sub>3</sub>O<sub>4</sub> and the low efficiency of mono treatments. The hybrid material, Fe<sub>3</sub>O<sub>4</sub>@Cu-TCPP, was assembled through hydrophobic interactions of... |
39848611 | Single Nucleotide Polymorphism Highlighted via Heterogeneous Light-Induced Dissipative Structure. | The unique characteristics of biological structures depend on the behavior of DNA sequences confined in a microscale cell under environmental fluctuations and dissipation. Here, we report a prominent difference in fluorescence from dye-modified single-stranded DNA in a light-induced assembly of DNA-functionalized heter... |
39848150 | Transcriptomic modifications across the genome and potential hazards of pulmonary fibrosis caused by metal-organic frameworks. | Metal-Organic Frameworks (MOFs) have shown great promise in environmental protection, owing to their exceptional properties including ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. However, emerging evidence from experimental studies indicates that MOFs have side effects on... |
39847767 | Light-Harvesting Spin Hyperpolarization of Organic Radicals in a Metal-Organic Framework. | Light-driven spin hyperpolarization of organic molecules is a crucial technique for spin-based applications such as quantum information science (QIS) and dynamic nuclear polarization (DNP). Synthetic chemistry provides the design of spins with atomic precision and enables the scale-up of individual spins to hierarchica... |
39847755 | Unraveling the Role of Functional Groups of Terephthalate in Enhancing the Electrochemical Oxygen Evolution Reaction of Nickel-Organic Framework Nanoarrays. | The platelike nickel-terephthalate-type metal-organic framework nanoarrays (Ni-BDC NAs) on carbon cloth are obtained by employing agaric-like Ni(OH)<sub>2</sub> NAs as sacrificial templates. The microenvironment of Ni-BDC NAs is modulated by various neighboring functional groups (-NH<sub>2</sub>, -NO<sub>2</sub>, and -... |
39847689 | A Potent Bis-Heteroleptic Ruthenium(II) Complex-Based Chalcogen Bonding Receptor for Selective Sensing of Phosphates. | The incorporation of a selenoimidazolium-based chalcogen bond (ChB) donor into a bis-heteroleptic Ru(II) complex (Ru-Se) has been designed for the first time to explore its anion-sensing properties and understand its selectivity to specific classes of anions. Photophysical studies demonstrate the receptor's selectivity... |
39847685 | Dipnictogen Radical Chemistry: A Dithorium-Supported Distibene Radical Trianion. | Although two examples of σ-bonded <i>trans</i>-bent [RSbSbR]<sup>•-</sup> (R = bulky organo- or Ga-groups) that formally contain the Sb<sub>2</sub><sup>•3-</sup> radical trianion moiety are known in p-block chemistry, d- or f-element Sb<sub>2</sub><sup>•3-</sup> radical trianion complexes, with or without R-substituent... |
39847625 | Systematic identification of Y-chromosome gene functions in mouse spermatogenesis. | The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In <i>Eif2s3y</i>, <i>Uty</i>, and <i>Zfy2</i> deletants, spermatogenesis was impaired. We found that <i>Uty</i> regulates spermatogonial prol... |
39847609 | Flexible Tail of Antimicrobial Peptide PGLa Facilitates Water Pore Formation in Membranes. | PGLa, an antimicrobial peptide (AMP), primarily exerts its antibacterial effects by disrupting bacterial cell membrane integrity. Previous theoretical studies mainly focused on the binding mechanism of PGLa with membranes, while the mechanism of water pore formation induced by PGLa peptides, especially the role of stru... |
39847604 | Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies. | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to persist, demonstrating the risks posed by emerging infectious diseases to national security, public health, and the economy. Development of new vaccines and antibodies for emerging viral threats requires substantial resources and time, and tradit... |
39847574 | Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants. | Expansion of atypical memory B cells (aMBCs) was demonstrated in malaria-exposed individuals. To date, the generation of P. vivax-specific aMBCs and their function in protective humoral immune responses is unknown. Here, P. vivax Duffy Binding Protein II (PvDBPII) probes were generated to detect the development and dur... |
39847512 | Enantiocontrolled Cyclization to Form Chiral 7- and 8-Membered Rings Unified by the Same Catalyst Operating with Different Mechanisms. | Chiral medium-sized rings, albeit displaying attractive properties for drug development, suffer from numerous synthetic challenges due to difficult cyclization steps that must take place to form these unusually strained, atropisomeric rings from sterically crowded precursors. In fact, catalytic enantioselective cycliza... |
39847480 | Superhydrophobic and Self-Healing Porous Organic Macrocycle Crystals for Methane Purification under Humid Conditions. | Purifying methane from natural gas using adsorbents not only requires the adsorbents to possess excellent separation performance but also to overcome additional daunting challenges such as humidity interference and durability requirements for sustainable use. Herein, porous organic crystals of a new macrocycle (<b>CaC9... |
39847124 | Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends. | Centrioles are microtubule-based organelles required for the formation of centrosomes and cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very slowly, but the underlying mechanisms are poorly understood. Here, we reconstituted in vitro the interplay between the proteins that cap... |
39847439 | Ultra-Sensitive Detection of Bacterial Spores via SERS. | Bacterial spores are highly resilient and capable of surviving extreme conditions, making them a persistent threat in contexts such as disease transmission, food safety, and bioterrorism. Their ability to withstand conventional sterilization methods necessitates rapid and accurate detection techniques to effectively mi... |
39847391 | Fully Atomistic Molecular Dynamics Simulation of Ice Nucleation Near an Antifreeze Protein. | Heterogeneous ice nucleation is a widespread phenomenon in nature. Despite extensive research on ice nucleation near biological antifreeze proteins, a probe for ice nucleation and growth processes at the atomic level is still lacking. Herein, we present simulation evidence of the heterogeneous ice nucleation process on... |
39847340 | Iron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter. | Chemical communication between marine bacteria and their algal hosts drives population dynamics and ultimately determines the fate of major biogeochemical cycles in the ocean. To gain deeper insights into this small molecule exchange, we screened niche-specific metabolites as potential modulators of the secondary metab... |
39847315 | Antibacterials with Novel Chemical Scaffolds in Clinical Development. | The rise of antimicrobial resistance represents a significant global health threat, driven by the diminishing efficacy of existing antibiotics, a lack of novel antibacterials entering the market, and an over- or misuse of existing antibiotics, which accelerates the evolution of resistant bacterial strains. This review ... |
39847327 | Molecular glue for phycobilisome attachment to photosystem II in <i>Synechococcus</i> sp. PCC 7002. | Phycobilisomes (PBS) are the major photosynthetic light-harvesting complexes in cyanobacteria and red algae. While the structures of PBS have been determined in atomic resolutions, how PBS are attached to the reaction centers of photosystems remains less clear. Here, we report that a linker protein (LcpA) is required f... |
39847205 | Navigating liver cancer: Precision targeting for enhanced treatment outcomes. | Cancer treatments such as surgery and chemotherapy have several limitations, including ineffectiveness against large or persistent tumors, high relapse rates, drug toxicity, and non-specificity of therapy. Researchers are exploring advanced strategies for treating this life-threatening disease to address these challeng... |
39847169 | Bimetallic metal-organic frameworks as electrode modifiers for enhanced electrochemical sensing of chloramphenicol. | An electrochemical sensor is presented for the detection of the chloramphenicol (CAP) based on a bimetallic MIL-101(Fe/Co) MOF electrocatalyst. The MIL-101(Fe/Co) was prepared by utilizing mixed-valence Fe (III) and Co (II) as metal nodes and terephthalic acid as ligands with a simple hydrothermal method and characteri... |
39847158 | Deciphering the mechanism for encapsulation of MOF (Fe-glutaric acid) onto Se/SnO<sub>2</sub> embedded CMC for effective aqueous sequestration of pharmaceutical pollutant via adsorption. | Wastewater is commonly contaminated with many pharmaceutical pollutants, so an efficient purification method is required for their removal from wastewater. In this regard, an innovative tertiary Se/SnO<sub>2</sub>@CMC/Fe-GA nanocomposite was synthesized through encapsulation of metal organic frameworks (Fe-glutaric aci... |
39847125 | Membranes of Polymer of Intrinsic Microporosity PIM-1 for Gas Separation: Modification Strategies and Meta-Analysis. | Polymers of intrinsic microporosity (PIMs) have received considerable attention for making high-performance membranes for carbon dioxide separation over the last two decades, owing to their highly permeable porous structures. However, challenges regarding its relatively low selectivity, physical aging, and plasticisati... |
39847086 | C1orf115 interacts with clathrin adaptors to undergo endocytosis and induces ABCA1 to promote enteric cholesterol efflux. | C1orf115 has been identified in high-throughput screens as a regulator of multidrug resistance possibly mediated through an interaction with ATP-dependent membrane transporter ABCB1. Here we show that C1orf115 not only shares structural similarities with FACI/C11orf86 to interact with clathrin adaptors to undergo endoc... |
39846961 | Experiment-Guided Refinement of Milestoning Network. | Milestoning is an efficient method for calculating rare event kinetics by constructing a continuous-time kinetic network that connects the reactant and product states. Its accuracy depends on both the quality of the underlying force fields and the trajectory sampling. The sampling error can be effectively controlled th... |
39846885 | A Unique Case of 'in Situ' Bifluoride Triggered Formation of Supramolecular Organogels Using Isophthalamide Hydrogen Bond Donating Receptors. | A novel isopthalamide based receptor H<sub>2</sub>L2 featuring two p-benzoic acid units has been synthesised and its anion binding properties analysed by <sup>1</sup>H-NMR spectroscopy in DMSO-d<sub>6</sub>/0.5 % H<sub>2</sub>O. As expected, in the presence of tetrabutylammonium (TBA) fluoride the deprotonation of the ... |
39846884 | Bio-Inspired Highly Stretchable and Ultrafast Autonomous Self-Healing Supramolecular Hydrogel for Multifunctional Durable Self-Powered Wearable Devices. | As skin bioelectronics advances, hydrogel wearable devices have broadened perspectives in environment sensing and health monitoring. However, their application is severely hampered by poor mechanical and self-healing properties, environmental sensitivity, and limited sensory functions. Herein, inspired by the hierarchi... |
39846739 | Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization. | Human astroviruses (HAstVs) are a leading cause of viral childhood diarrhea that infects nearly every individual during their lifetime. Although human astroviruses are highly prevalent, no approved vaccine currently exists. Antibody responses appear to play an important role in protection from HAstV infection; however,... |
39846395 | Decontamination and Surface Analysis of PFAS-Contaminated Fire Suppression System Pipes: Effects of Cleaning Agents and Temperature. | Per- and polyfluoroalkyl substances (PFAS)-containing firefighting foam have been used in stationary fire suppression systems for several decades. However, there is a lack of research on how to decontaminate PFAS-contaminated infrastructure and evaluate treatment efficiency. This study assessed the removal of PFAS from... |
39846333 | Plasmonic Single-Molecule Affinity Detection at 10<sup>-20</sup> Molar. | DNA can be readily amplified through replication, enabling the detection of a single-target copy. A comparable performance for proteins in immunoassays has yet to be fully assessed. Surface-plasmon-resonance (SPR) serves as a probe capable of performing assays at concentrations typically around 10⁻⁹ molar. In this stud... |
39846334 | Nano-Metal-Organic Frameworks Isolated in Mesoporous Structures. | As an alternative to bulk counterparts, metal-organic framework (MOF) nanoparticles isolated within conductive mesoporous carbon matrices are of increasing interest for electrochemical applications. Although promising, a "clean" carbon surface is generally associated with poor compatibility and weak interactions with m... |
39846332 | Salt-Compact Albumin as a New Pure Protein-based Biomaterials: From Design to In Vivo Studies. | Current biodegradable materials are facing many challenges when used for the design of implantable devices because of shortcomings such as toxicity of crosslinking agents and degradation derivatives, limited cell adhesion, and limited immunological compatibility. Here, a class of materials built entirely of stable prot... |
39846310 | Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects. | Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long-term hospitalization, and high medical costs have driven the efforts of the scientific community to develop new therapies to improve the situa... |
39846284 | Anti-Scattering Perovskite Scintillator Arrays for High-Resolution Computed Tomography Imaging. | Computed tomography (CT) imaging has emerge as an effective medical diagnostic technique due to its rapid and 3D imaging capabilities, often employing indirect imaging methods through scintillator materials. Arraying scintillators that can confine light scattering to enable high-resolution CT imaging remains an area of... |
39844780 | Enzyme-Instructed Interfacial Jamming of Pillar[5]arenes for Macroscopic Signal Amplification. | Enzyme-instructed signal generation at liquid-liquid interfaces presents a novel strategy for controlling and detecting biochemical processes on macroscopic scales. Here, we explore the self-assembly and jamming of pillar[5]arene (P[5]A) derivatives at the oil-water interface via a copper-mediated "click" reaction, pro... |
39844743 | Virulence and pathogenicity of group B <i>Streptococcus</i>: Virulence factors and their roles in perinatal infection. | This review summarizes key virulence factors associated with group B <i>Streptococcus</i> (GBS), a significant pathogen particularly affecting pregnant women, fetuses, and infants. Beginning with an introduction to the historical transition of GBS from a zoonotic pathogen to a prominent cause of human infections, parti... |
39844695 | Upcycling of Organic and Inorganic Waste into MIL-88B(Fe) at Room Temperature for Tetracycline Degradation. | Upcycling organic and inorganic waste into value-added metal-organic frameworks (MOFs) presents a sustainable strategy for mitigating waste pollution and promoting economic viability. However, rapid synthesis of MOF materials derived from actual industrial waste under mild conditions remains challenging. Herein, Fe-MOF... |
39843477 | Ion bridging enables high-voltage polyether electrolytes for quasi-solid-state batteries. | Polyether electrolytes have been widely recognized for their favorable compatibility with lithium-metal, yet they are hampered by intrinsically low oxidation thresholds, limiting their potential for realizing high-energy Li-metal batteries. Here, we report a general approach involving the bridge joints between non-lith... |
39842483 | PERspectives on circadian cell biology. | Daily rhythms in the activities of PERIOD proteins are critical to the temporal regulation of mammalian physiology. While the molecular partners and genetic circuits that allow PERIOD to effect auto-repression and regulate transcriptional programmes are increasingly well understood, comprehension of the time-resolved m... |
39842469 | Formulation Advances in Posterior Segment Ocular Drug Delivery. | Posterior segment ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, are leading causes of vision impairment and blindness worldwide. Effective management of these conditions remains a formidable challenge due to the unique anatomical and physiological barriers ... |
39828636 | Synergistic Effects of Fluorinated Li-Based Metal-Organic Framework Filler on Matrix Polarity and Anion Immobilization in Quasi-Solid State Electrolyte for Lithium-Metal Batteries. | Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) based electrolyte is a promising alternative to liquid electrolytes in lithium metal batteries. However, its commercial application is limited by high crystallinity and low Li<sup>+</sup> ion conductivity. In this study, we synthesized a fluorinated Li-based m... |
39807090 | Continuous Production of Bifunctional Platform Chemicals From Plant Oils in Water by Cyclodextrin-Mediated Hydroformylation. | Platform chemicals from renewable resources with broad applications are highly desirable, particularly for replacing fossil-based monomers. Bifunctional aliphatic ester-aldehydes, accessible via regioselective hydroformylation of unsaturated oleochemicals, can be converted into linear ω-amino/ω-hydroxy esters and dicar... |
39805800 | Integrating Enzymes with Reticular Frameworks To Govern Biocatalysis. | Integrating enzymes with reticular frameworks offers promising avenues for access to functionally tailorable biocatalysis. This Minireview explores recent advances in enzyme-reticular framework hybrid biocomposites, focusing on the utilization of porous reticular frameworks, including metal-organic frameworks, covalent... |
39789989 | Ring-in-Ring Assembly Facilitates the Synthesis of a [12]Cycloparaphenylene ABC-Type [3]Catenane. | Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem and explore the fundamental and functional properties of CPP rotaxanes and ... |
39780698 | Synthesis of an ammelide-based ultra-microporous Cd-MOF for sensitive detection of dichromate ions. | This study introduces the first metal organic framework using ammelide as the organic ligand, showcasing stability in boiling water and high sensitivity in detecting dichromate ions. |
39775627 | Host-guest recognition-mediated reversible and orthogonal regulation of DNAzyme activity. | The host-guest recognition system is incorporated into the core region of the 10-23 DNAzyme for precise regulation of its functionality. Biochemical experiments demonstrate reversible and orthogonal control of the DNAzyme function using cucurbit(7)uril and its competitive guests. Furthermore, cellular experiments indic... |
39760482 | Two novel lanthanide metal-organic frameworks based on tetraphenylethylene for ultra-high proton conduction. | Two novel isostructural anionic lanthanide metal-organic frameworks, (Me<sub>2</sub>NH<sub>2</sub>)[Ln(HTCBPE-F)·(HCOO)·DMF]·4.5DMF·2H<sub>2</sub>O (Eu-MOF and Dy-MOF), based on tetraphenylethylene carboxylate ligands were successfully constructed and characterized. These two MOFs possess porous structures and water st... |
39749368 | Chiral synthetic hosts for efficient enantioselective molecular recognition. Design principles and synthetic aspects. | Discrimination of enantiomeric substrate molecules is one of the fundamental properties of biological hosts. Replicating enantioselective molecular recognition with synthetic receptors is a topic of interest with implications in diverse applications such as bioinspired enantioselective catalysis, enantiomer separation,... |
39711316 | Chitosan as a fluorescent probe for the detection of the AIE-active food colorant quinoline yellow. | The greenish-yellow synthetic dye quinoline yellow (Qy) is widely used in the food and pharmaceutical industries. However, this dye may lead to health and environmental problems. Therefore, investigating how Qy interacts with biological macromolecules is of great interest. In this work, Qy was found to be a novel AIEge... |
39703014 | A metal organic framework, UiO-66-NH<sub>2</sub>, based on a molybdenum Schiff base complex for the efficient electrochemical determination of diphenoxylate. | Diphenoxylate, an agonist and opioid agent, is applied to enhance the activity of the circular muscle of the intestine. In this work, we prepared a novel electrochemical sensor for the determination of diphenoxylate based on a modified UiO-66-NH<sub>2</sub> metal-organic framework (UiO-66-NH<sub>2</sub> MOF) using a mo... |
39696996 | A simple and stable dual-emission fluorescent system based on R6G/Eu-MOF for the rapid and sensitive determination of orientin. | A stable dual-emission fluorescent system, R6G/Eu-MOF, was obtained by simple mixing Eu-MOF with fluorescent rhodamine 6G (R6G). This system not only achieved robust dual luminescence performance at 430 nm (Eu-MOF) and 555 nm (R6G) under single-wavelength excitation, but also endowed it with significantly improved fluo... |
39663843 | Rational design of NiCo<sub>2</sub>O<sub>4</sub>@carbon hollow spheres as a high-performance electrode material for flexible supercapacitors. | The design of innovative, flexible electrode materials with high electrochemical performance is critical for the development of next-generation supercapacitors. Here, we report the rational synthesis of NiCo<sub>2</sub>O<sub>4</sub>@carbon hollow spheres, engineered <i>via</i> a metal-organic framework (MOF)-templated ... |
39655517 | Development of supramolecular ionic gels with self-healing capability and biodegradability using a bioderived ionic liquid and poly(vinyl alcohol). | Gels are promising candidates for environmental sensing and implants because of their high stretchability, ionic conductivity, and low toxicity toward the environment and human body. Self-healing gels can recover their mechanical and electrical properties after rupturing under environments with harsh mechanical stress.... |
39651803 | Face-controlled chirality induction in octahedral thiacalixarene-based porous coordination cages. | Nanosized chiral octahedral M<sub>32</sub> coordination cages were prepared <i>via</i> self-assembly of sulfonylcalix[4]arene tetranuclear M(II) clusters (M = Co or Ni) with enantiomerically enriched linkers based on tris(dipyrrinato)cobalt(III) complexes, appended with peripheral carboxylic groups. Two pairs of enanti... |
39641532 | Systematic probing of protein adsorption on protein-based nanoparticles in dependence of the particle surface charge. | Understanding protein adsorption on the surface of nanoparticles (NPs) is crucial for determining their behavior in biological environments. Early research in this field faced challenges in producing high-quality NPs. Advancements in NP fabrication now allow for precise modifications of specific parameters, such as zet... |
40584013 | Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis. | <h4>Context</h4>Fracture risk in patients on long-term glucocorticoid (LTGC) is only partially explained by impaired areal bone mineral density (aBMD). HR-pQCT derived bone microstructure and bone strength indices could improve fracture prediction beyond aBMD or FRAX in the general population. Abnormalities in these in... |
40502620 | In Situ Ligand Transformation for the Development of Luminescent 3D Metal-Organic Frameworks with Diamond-like Topology. | Here, the synthesis by a soft solvothermal route of two novel isoreticular compounds based on the in situ generated (by a nucleophilic aromatic substitution) 2-hydroxi-5-(trifluoromethyl)-pyrimidine (H<sub>1</sub>L) ligand and Zn-(II) and Cd-(II) as metallic centers (with the general formula [ML<sub>2</sub>]<sub>n</sub... |
40470328 | Oxidant-free cross-dehydrogenative oxyalkylation enables late-stage functionalization of drugs. | Late-stage functionalization is an attractive strategy that allows chemists to bypass lengthy synthetic processes, facilitating the rapid generation of drug analogs with potentially enhanced pharmacokinetic and pharmacological properties. This study describes a novel approach for cross-dehydrogenative oxyalkylation, le... |
40124959 | A General Amino-(Hetero)arylation of Simple Olefins with (Hetero)aryl Sulfonamides Enabled by an <i>N</i>-Triazinyl Group. | (Hetero)arylethylamines are privileged substructures in pharmaceuticals, agrochemicals, and other bioactive compounds. In principle, the amino-(hetero)arylation of olefins represents an ideal strategy for the rapid preparation of these pharmacophores, which could accelerate the discovery of valuable new products. Estab... |
40110521 | Atomic-level engineering of single Ag<sup>1+</sup> site distribution on titanium-oxo cluster surfaces to boost CO<sub>2</sub> electroreduction. | Precise control over the distribution of active metal sites on catalyst surfaces is essential for maximizing catalytic efficiency. Addressing the limitations of traditional cluster catalysts with core-embedded catalytic sites, this work presents a strategy to position catalytic sites on the surfaces of oxide clusters. ... |
40081105 | Cyclic nucleotide phosphodiesterases as drug targets. | Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellul... |
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