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39856354 | In situ forming gels as subcutaneous delivery systems of curcumin and piperine. | In this study an in situ forming gel for curcumin and piperine delivery is investigated as a long-lasting strategy in the local treatment of inflammatory and degenerative joint disease, such as osteoarthritis and rheumatoid arthritis. Particularly glyceryl monooleate, in association with phosphatidylcholine and ethanol... |
39856261 | Surgical stabilisation of rib fractures in non-ventilated patients: a retrospective propensity-matched analysis using the data from the trauma registry of the German Trauma Society (TraumaRegister DGU<sup>Ⓡ</sup>). | <h4>Purpose</h4>Severe thorax trauma including multiple rib fractures and flail chest deformity are leading causes of death in trauma patients. Increasing evidence supports the use of surgical stabilisation of rib fractures (SSRF) in these patients. However, there is currently a paucity of evidence for its use in non-v... |
39856195 | A data driven machine learning approach for predicting and optimizing sulfur compound adsorption on metal organic frameworks. | This study employed some machine learning (ML) techniques with Python programming to forecast the adsorption capacity of MOF adsorbents for thiophenic compounds namely benzothiophene (BT), dibenzothiophene (DBT), and 4,6-dimethyl dibenzothiophene (4,6-DMDBT). Five ML models were developed with the help of a dataset con... |
39856186 | Design of asymmetric electrolytes for aqueous zinc batteries. | Aqueous Zn batteries are gaining increasing research attention in the energy storage area due to their intrinsic safety, potentially low cost and environmental friendliness; however, the zinc dendrite formation, zinc corrosion, passivation and the hydrogen evolution reaction induced by water at the anode side, and mate... |
39856185 | Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer. | Epithelial-mesenchymal transition (EMT) is designated as one of the prime causes of chemoresistance in many cancers. In our previous study we established that cisplatin resistance in ovarian cancer (OC) is associated with EMT using sensitive OV90 cells and its resistant counterparts OV90CisR1 and OV90CisR2. In this stu... |
39856174 | L-Histidine-functionalized KIT-6 with embedded palladium nanoparticles as an efficient heterogeneous catalyst for oxidation of sulfide to sulfoxide and amination of aryl halides. | Palladium nanoparticles were supported on L-H-functionalized KIT-6 (KIT-6@L-H-Pd) and evaluated using various characterization techniques such as TGA, FT-IR, SEM, XRD, EDS, and BET. KIT-6@L-H-Pd showed excellent catalytic performance as a recyclable nanocatalyst for the oxidation of sulfides to sulfoxides and the amina... |
39856123 | Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins. | Bacterial cell division and plant chloroplast division require selfassembling Filamentous temperature-sensitive Z (FtsZ) proteins. FtsZ proteins are GTPases sharing structural and biochemical similarities with eukaryotic tubulin. In the moss Physcomitrella, the morphology of the FtsZ polymer networks varies between the... |
39856089 | Artificial cells with all-aqueous droplet-in-droplet structures for spatially separated transcription and translation. | The design of functional artificial cells involves compartmentalizing biochemical processes to mimic cellular organization. To emulate the complex chemical systems in biological cells, it is necessary to incorporate an increasing number of cellular functions into single compartments. Artificial organelles that spatiall... |
39856040 | Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use. | Human papillomaviruses, particularly high-risk human papillomaviruses, have been universally considered to be associated with the oncogenesis and progression of various cancers. The genome of human papillomaviruses is circular, double-stranded DNA that encodes early and late proteins. Each of the proteins is of crucial... |
39856039 | COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines. | Two or more catalysts conducting multistep reactions in the same reactor, concurrent tandem catalysis, could enable (bio)pharmaceutical and fine chemical manufacturing to become much more sustainable. Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent or... |
39856033 | Chemical catalyst manipulating cancer epigenome and transcription. | The number and variety of identified histone post-translational modifications (PTMs) are continually increasing. However, the specific consequences of each histone PTM remain largely unclear, primarily due to the lack of methods for selectively and rapidly introducing a desired histone PTM in living cells without genet... |
39855639 | Characterization of Sugammadex-Related Isomeric Cyclodextrin Impurities Using Cyclic Ion Mobility High-Resolution Mass Spectrometry. | Cyclic ion mobility-mass spectrometry (cIM-MS) is a powerful technique for separating and identifying isomeric mixtures of compounds. When coupled with chromatography, cIM-MS creates a multidimensional separation system, with high resolving power and peak capacity. In this study, we report the cyclic ion mobility separ... |
39854729 | Introducing Pyridone[α]-Fused BOPHYs as Red-Shifted Bright Fluorophore Potentially Useful as Non-fullerene Acceptors in Donor-Acceptor Dyads. | A series of 2-pyridone[α]-fused BOPHYs <b>6</b>-<b>8</b> were prepared via a two-step procedure involving the preparation of enamine, followed by an intramolecular heterocyclization reaction. In addition to being fully conjugated with the BOPHY core pyridone fragment, BOPHYs <b>7</b> and <b>8</b> have a pyridine group ... |
39854684 | A Second Near-Infrared Window-Responsive Metal-Organic-Framework-Based Photosensitizer for Tumor Immunotherapy via Synergistic Ferroptosis and STING Activation. | Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced therapy precision and safety. To enhance deep tissue penetration and minimize tissue adsorption and phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significa... |
39854601 | Diverse autoinhibitory mechanisms of FIIND-containing proteins: Insight into regulation of NLRP1 and CARD8 inflammasome. | Function-to-find domain (FIIND)-containing proteins, including NLRP1 and CARD8, are vital components of the inflammasome signaling pathway, critical for the innate immune response. These proteins exist in various forms due to autoproteolysis within the FIIND domain, resulting in full-length (FL), cleaved N-terminal (NT... |
39854499 | Discovery of an Ultralong-acting Nondepolarizing Neuromuscular Blocker That Displays Short Onset Time and On-Demand Rapid Reversal by a Biocompatible Antagonist. | The combination of ultralong-acting neuromuscular block and subsequent on-demand rapid reversal may provide prolonged surgeries with improved conditions by omitting continuous or repetitive blocker administration, enabling a more stable and predictable hemodynamic profile and eliminating residual block. For this target... |
39854479 | Human naïve B cells recognize prepandemic influenza virus hemagglutinins. | Understanding the naïve B cell repertoire and its specificity for potential zoonotic threats, such as the highly pathogenic avian influenza (HPAI) H5Nx viruses, may allow prediction of infection- or vaccine-specific responses. However, this naïve repertoire and the possibility to respond to emerging, prepandemic viruse... |
39854441 | Secondary metabolites of Alternaria alternate appraisal of their SARS-CoV-2 inhibitory and anti-inflammatory potentials. | This study identifies the secondary metabolites from Alternaria alternate and evaluates their ACE-2: Spike RBD (SARS-CoV-2) inhibitory activity confirmed via immunoblotting in human lung microvascular endothelial cells. In addition, their in vitro anti-inflammatory potential was assessed using a cell-based assay in LPS... |
39854420 | mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii. | Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous vacuole (PV) which shields the parasite from the host's... |
39854345 | Development of a multi-epitope chimeric vaccine in silico against Babesia bovis, Theileria annulata, and Anaplasma marginale using computational biology tools and reverse vaccinology approach. | The three rickettsial parasites- Babesia bovis, Theileria annulata and Anaplasma Marginale are responsible for causing Babesiosis, Theileriosis and Anaplasmosis among cattle. These diseases exist due to spreading of infected ticks. A large number of cattle were found to suffer from mixed infections caused by the three ... |
39854342 | Computational design of multi-epitope vaccine against Hepatitis C Virus infection using immunoinformatics techniques. | Hepatitis C Virus (HCV) is a blood borne pathogen that affects around 200 million individuals worldwide. Immunizations against the Hepatitis C Virus are intended to enhance T-cell responses and have been identified as a crucial component of successful antiviral therapy. Nevertheless, attempts to mediate clinically rele... |
39854314 | Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission. | <h4>Background</h4>Schistosoma haematobium is the causative pathogen for urogenital schistosomiasis. To achieve progress towards schistosomiasis elimination, there is a critical need for developing highly sensitive and specific tools to monitor transmission in near-elimination settings. Although antibody detection is a... |
39854296 | Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae. | Rice blast, caused by Magnaporthe oryzae, is one of the most destructive fungal diseases in rice, resulting in major economic losses worldwide. Genetic and genomic studies have identified key genes and proteins, such as AvrPik variants and MAX proteins, that are crucial for the pathogen's virulence. These effector prot... |
39854290 | Highly Nucleophilic Pyridinamide Anions in Apolar Organic Solvents due to Asymmetric Ion Pair Association. | Free ions in organic solvents of low polarity would be valuable tools for the activation of low-reactivity substrates. However, the formation of unreactive ion pairs at concentrations relevant for synthesis has prevented the success of this concept so far. On the example of highly nucleophilic pyridinamide phosphonium ... |
39854249 | Electron Microscopy Reveals Inhomogeneous Adsorption of Iodine and Concurrent Defect Formation in a Metal-Organic Framework. | Adsorption behaviors are typically examined through adsorption isotherms, which measure the average adsorption amount as a function of partial pressure or time. However, this method is incapable of identifying inhomogeneities across the adsorbent, which may occur in the presence of strong intermolecular interactions of... |
39854238 | Life sets off a cascade of machines. | Life is invasive, occupying all physically accessible scales, stretching between almost nothing (protons, electrons, and photons) and almost everything (the whole biosphere). Motivated by seventeenth-century insights into this infinity, this paper proposes a language to discuss life as an infinite double cascade of mac... |
39854229 | Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live <i>Escherichia coli</i> cells. | The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here... |
39854179 | Hierarchical S-Doped Vanadium MOFs with Multiwalled Carbon Nanotubes: A Robust Bifunctional Catalyst for Efficient Water Electrolysis. | Developing nonprecious metal-based electrocatalysts with exceptional activity and durability for water electrolysis remains a significant challenge. Herein, we report a highly efficient bifunctional electrocatalyst composed of sulfur-doped vanadium metal-organic frameworks (S@V-MOF) integrated with multiwalled carbon n... |
39854164 | Inulin Dehydration to 5-HMF in Deep Eutectic Solvents Catalyzed by Acidic Ionic Liquids Under Mild Conditions. | Valorization of carbohydrate-rich biomass by conversion into industrially relevant products is at the forefront of research in sustainable chemistry. In this work, we studied the inulin conversion into 5-hydroxymethylfurfural, in deep eutectic solvents, in the presence of acidic task-specific ionic liquids as catalysts... |
39854149 | Protective effects of neutrophil serine protease inhibition against ischemia-reperfusion injury in lung or heart transplantation. | Transplanted organs are inevitably exposed to ischemia-reperfusion (IR) injury, which is known to cause graft dysfunction. Functional and structural changes that follow IR tissue injury are mediated by neutrophils through the production of oxygen-derived free radicals, as well as from degranulation which entails the re... |
39854126 | Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment. | Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates and poor patient prognosis. The heterogeneity and complex biology of GBM, coupled with the protective nature of the blood-brain barrier (BBB), significantly limit the effic... |
39853948 | Visible-Light Photo-Iniferter Polymerization of Molecularly Imprinted Polymers for Direct Integration with Nanotransducers. | Molecularly Imprinted Polymers (MIPs) have gained prominence as synthetic receptors, combining simplicity of synthesis with robust molecular recognition akin to antibodies and enzymes. One of their main application areas is chemical sensing. However, direct integration of MIPs with nanostructured transducers, crucial f... |
39853942 | Fabrication of Multifunctional Three-Component Supramolecular Nano-Biscuits via Two Macrocycles-Involved Self-Assembly for Rice, Citrus and Kiwifruit Protections. | Bacterial plant diseases, worsened by biofilm-mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, ... |
39853921 | Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation. | Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization of corneal stroma is challenging. In this study, humanized corneal stroma-like adhesive patches (HCSPs) are prepare... |
39853638 | Ultrasensitive Chemiresistive Gas Sensors Based on Dual-Mesoporous Zinc Stannate Composites for Room Temperature Rice Quality Monitoring. | The integration of dual-mesoporous structures, the construction of heterojunctions, and the incorporation of highly concentrated oxygen vacancies are pivotal for advancing metal oxide-based gas sensors. Nonetheless, achieving an optimal design that simultaneously combines mesoporous structures, precise heterojunction m... |
39853354 | Efficient extraction via titanium organic frameworks facilitates in-depth profiling of urinary exosome metabolite fingerprints. | Urinary exosome metabolite analysis has demonstrated notable advantages in uncovering disease status, yet its potential in decoding the intricacies of clear cell renal cell carcinoma (ccRCC) remains untapped. To address this, a core-shell magnetic titanium organic framework was designed to capture urinary exosomes and ... |
39853207 | Characterisation of <i>Proteus mirabilis</i> isolates from the poultry production chain in Zhejiang Province, China: antimicrobial resistance, virulence factors and genotypic profiling. | 1. This study investigated antimicrobial resistance, virulence factors and genotypic profiling among <i>Proteus mirabilis</i> isolated from three sources (poultry farms, slaughterhouses and retail markets) in the poultry production chain in Zhejiang Province, China, to assess its potential risk to public health.2. A to... |
39853159 | Conformational versatility among crystalline solids of L-phenylalanine derivatives. | In this study, we present a new N-derivative of L-phenylalanine with 2-naphthaldehyde (PN), obtained by the Schiff base formation procedure and its subsequent reduction. This compound was crystallized as a zwitterion {2-[(naphthalen-2-ylmethyl)azaniumyl]-3-phenylpropanoate, C<sub>20</sub>H<sub>19</sub>NO<sub>2</sub>}, ... |
39853121 | <i>In vitro</i> and <i>in vivo</i> activity of 1,2,3,4,6-O-pentagalloyl-glucose against <i>Candida albicans</i>. | Invasive fungal infections have become an increasingly serious threat to global human health, underscoring the urgent need for the development of new antifungal drugs. In this study, we found a natural polyphenolic compound 1,2,3,4,6-O-pentagalloyl-glucose (PGG), which is present in various plants and herbs. PGG showed... |
39853118 | Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins. | Interlinked interactions between the viral capsid (CA), nucleoporins (Nups), and the antiviral protein myxovirus resistance 2 (MX2/MXB) influence human immunodeficiency virus 1 (HIV-1) nuclear entry and the outcome of infection. Although RANBP2/NUP358 has been repeatedly identified as a critical player in HIV-1 nuclear... |
39853090 | Dynamics and regulatory roles of RNA m<sup>6</sup>A methylation in unbalanced genomes. | <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) in eukaryotic RNA is an epigenetic modification that is critical for RNA metabolism, gene expression regulation, and the development of organisms. Aberrant expression of m<sup>6</sup>A components appears in a variety of human diseases. RNA m<sup>6</sup>A modificatio... |
39852765 | Synthesis and Self-Assembly of Monodisperse Graphene Nanoribbons: Access to Submicron Architectures with Long-Range Order and Uniform Orientation. | Fabricating organic semiconducting materials into large-scale, well-organized architectures is critical for building high-performance molecular electronics. While graphene nanoribbons (GNRs) hold enormous promise for various device applications, their assembly into a well-structured monolayer or multilayer architecture... |
39851205 | Construction of Self-Cleaning Membrane Integrating Underwater Superoleophobicity, Photocatalysis, and Antibacterial Activity for Water Purification. | The treatment of oily wastewater and oil/water mixtures has received more and more attention. In this study, a Zn-MOF (ZIF-8) decorated polyimide (PI) nanofiber membrane with triple self-cleaning performance was constructed, and the decoration of ZIF-8 on the PI membrane improved the hydrophilicity of the composite mem... |
39850001 | Constructing Robust Interfaces in CoSe<sub>2</sub>/Nitrogen-Doped Carbon for Superior Long-Life Sodium-Ion Storage. | Robust interfaces in anodes play a crucial role in boosting sodium-ion battery (SIB) performance. However, the fragile interfaces constructed by a two-step synthesis or artificial stack are prone to be destroyed during the charging/discharging processes, which significantly reduces the lifetime of SIBs. Here, a facile ... |
39849977 | Photoluminescent Properties of Tb-UiO-66 Metal-Organic Framework Analogues. | Three new analogues of Tb-UiO-66 with various functional groups (-F, -Br, -NH<sub>2</sub>) on the terephthalic acid linker of the metal-organic framework (MOF) are synthesized and characterized. The photoluminescent properties of these analogues, as well as Tb-UiO-66 and Tb-UiO-66-(OH)<sub>2</sub>, are studied and corr... |
39849540 | Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification. | The acidic tumor microenvironment, a hallmark of many solid tumors, is primarily induced by the high glycolytic rate of tumor cells. To avoid acidosis, tumor cells ingeniously maintain an acidic extracellular pH while keeping a relatively alkaline intracellular pH. Overturning the unique pH gradient of tumor cells has ... |
39817699 | Novel Cationic Bolaamphiphiles for Protein and DNA Binding, Gene Delivery, and Antimicrobial Applications. | In this study, we have designed and developed a cationic bolaform C<sub>12</sub>-(2,3-dihydroxy-N, N-dimethyl-N-(2-ureidoethyl)propan-1-aminium chloride)<sub>2</sub> (C<sub>12</sub>(DDUPAC)<sub>2</sub>) that is derived from biocompatible molecules. The bolaform C<sub>12</sub>(DDUPAC)<sub>2</sub> has hydroxyl (OH) funct... |
39809711 | Highly Efficient Schottky Heterojunctions for Photocatalytic Hydrogen Evolution: Facile Synthesis of Hollow Nano-ZnSe Spheres on Ti<sub>3</sub>C<sub>2</sub>-Nanosheets. | Traditional photocatalysts often have limited efficiency due to the high recombination rate of photogenerated electron-hole pairs. In this work, we synthesized 3D/2D ZnSe-MXene Schottky heterojunctions by an in situ electrostatic self-assembly method. Notably, the 3 % MXene-ZnSe composite exhibited an optimized photoca... |
39715078 | Effect of Protonation-Induced Distortions on the Spectral Properties and Electronic Structure of Octaphenylporphyrins through UV-Vis and VT-NMR Spectral, Electrochemical and Ab Initio Studies. | The extent of conformational change of the porphyrin macrocycle during the course of protonation was observed, both experimentally and theoretically. For synthesised β-substituted octaphenylporphyrin (OPP) ring systems, these macrocyclic distortions have been investigated by spectrophotometric titrations, electrochemic... |
41050114 | Mechanistic insights into honey-boiled detoxification of ChuanWu: A study on alkaloid transformation and supramolecular aggregation. | ChuanWu (CW), the dried mother root of <i>Aconitum carmichaelii</i> Debx., is a well-known traditional Chinese medicine (TCM) recognized for its potent efficacy but inherent toxicity, primarily due to its alkaloid content. Traditional and modern detoxification methods for CW include proper processing, rational compatib... |
40491677 | Enhancing temozolomide <i>in vivo</i> stability and efficacy through hybrid nanoconjugate approach for improved glioblastoma multiforme treatment. | Temozolomide (TMZ) is considered as a standard-of-care DNA alkylating agent for treating glioblastoma multiforme. Despite being a highly potent molecule, TMZ poses several limitations, including short half-life, rapid metabolism, low brain bioavailability and dose-dependent toxicities. Attempts have been made to improv... |
40177403 | Harnessing native blueprints for designing bioinks to bioprint functional cardiac tissue. | Cardiac tissue lacks regenerative capacity, making heart transplantation the primary treatment for end-stage heart failure. Engineered cardiac tissues developed through three-dimensional bioprinting (3DBP) offer a promising alternative. However, reproducing the native structure, cellular diversity, and functionality of... |
40104069 | ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm. | Oxidative stress, particularly ROS accumulation, plays a key role in the development of abdominal aortic aneurysm (AAA). Surgical treatments and current drugs for AAA have limitations, including lack of specificity and significant side effects. This study constructed ROS-responsive nanoparticles using phenylthio-modifi... |
40078882 | Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children. | The growth plate is crucial for skeletal growth in children, but research on repairing growth plate damage and restoring growth is limited. Here, a high-toughness adaptive dual-crosslinked hydrogel is designed to mimic the growth plate's structure, supporting regeneration and bone growth. Composed of aldehyde-modified ... |
40071223 | Gadolinium-Based Contrast Agents (GBCAs) for MRI: A Benefit-Risk Balance Analysis from a Chemical, Biomedical, and Environmental Point of View. | Gadolinium-based contrast agents (GBCAs) have revolutionized medical imaging, enhancing the accuracy and diagnostic value of magnetic resonance imaging (MRI). The increasing use of GBCAs has raised concerns about the release of gadolinium (Gd)(III) into the environment and potential risks for human health. Initially, m... |
40034561 | Development of a novel bivalent vaccine candidate against hepatitis A virus and rotavirus using reverse vaccinology and immunoinformatics. | The hepatitis A virus (HAV) and rotavirus are mainly transmitted through fecal-oral and person-to-person contact, and cause severe gastrointestinal complications and liver disease. This work used reverse vaccinology and immunoinformatic methods to create a novel bivalent vaccine against rotavirus and HAV. The amino aci... |
40022333 | Unveiling the formation capacity and characterization of pentacyclic triterpene-structured oleogels: Role of the molecular configuration and oil profile. | This research explored the impact of molecular structure and oil type on the formation and structural attributes of pentacyclic triterpene-structured oleogels. Characterization revealed that pentacyclic triterpenes have the propensity to self-assemble into nano- or micron-structures within the oil matrix. These nano- o... |
40017753 | Acceleration and Selectivity of 1,3-Dipolar Cycloaddition Reactions Included in a Polar [4 + 2] Octa-imine Bis-calix[4]pyrrole Cage. | We describe the quantitative self-assembly (>90%) of a [4 + 2] octa-imine cage (<b>1</b>) in a CDCl<sub>3</sub>:CD<sub>3</sub>CN 9:1 solvent mixture containing 0.5% of acetic acid. Cage <b>1</b> is based on two identical aryl-extended calix[4]pyrrole units linked through eight dynamically reversible imine bonds. Cage <... |
40015899 | Inhibitory effect of organometallic framework composite nanomaterial ZIF8@ZIF67 on different pathogenic microorganisms of silkworms. | The domestic silkworm (Bombyx mori) is of considerable economic importance, but is highly susceptible to various pathogens, which leads to substantial losses in sericulture. Nanomaterials, particularly metal-organic frameworks (MOFs), have shown promise in antibacterial applications due to their broad-spectrum activity... |
40006906 | Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways. | Viruses frequently exploit the host's nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors (NTRs) and nucleoporins within the spiderweb-like inner channel of th... |
40006903 | The Role of Plant Virus-like Particles in Advanced Drug Delivery and Vaccine Development: Structural Attributes and Application Potential. | Plant virus-like particles (pVLPs) present distinct research advantages, including cost-effective production and scalability through plant-based systems, making them a promising yet underutilized alternative to traditional VLPs. Human exposure to plant viruses through diet for millions of years supports their biocompat... |
40006901 | Primordial Biochemicals Within Coacervate-Like Droplets and the Origins of Life. | An organism is considered "alive" if it can grow, reproduce, respond to external stimuli, metabolize nutrients, and maintain stability. By this definition, both mitochondria and viruses exhibit the key characteristics of independent life. In addition to their capacity for self-replication under specifically defined con... |
40006518 | Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Time Response. | <b>Background:</b> This study demonstrates the application of the sequential design of experiments (DoE) approach within the quality by design (QbD) framework to optimize extrusion processes through screening, optimization, and robustness testing. <b>Methods:</b> An in-line UV-Vis process analytical technology (PAT) sy... |
40006519 | Novel Solid Forms of Cardarine/GW501516 and Their Characterization by X-Ray Diffraction, Thermal, Computational, FTIR, and UV Analysis. | Cardarine (C<sub>21</sub>H<sub>18</sub>F<sub>3</sub>NO<sub>3</sub>S<sub>2</sub>), better known by the popular name of GW501516, is a peroxisome proliferator-activated receptor delta (PPR-δ) agonist that presents potential use in the approach of cardiovascular diseases and metabolic disorders, dyslipidemia, and insulin ... |
40005611 | Microbiota Dysbiosis: A Key Modulator in Preeclampsia Pathogenesis and Its Therapeutic Potential. | Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. Emerging evidence implicates gut and vaginal microbiota dysbiosis in preeclampsia pathogenesis through its roles in immune regulation, inflammation, and placental function. This review explores the mechanisms linking microbiota... |
40005488 | Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review. | Dental caries is the most common oral disease in the world and a chronic infectious disease. The cariogenic microbiome plays an important role in the process of caries. The ecological imbalance of microbiota leads to low pH, which causes caries. Therefore, antibacterial materials have always been a hot topic. Tradition... |
40003571 | Bioinformatic Selection of Mannose-Specific Lectins from <i>Allium genus</i> as SARS-CoV-2 Inhibitors Analysing Protein-Protein Interaction. | Mannose-specific lectins are carbohydrate-binding proteins known for their antiviral potential. This study uses a bioinformatic approach to investigate the possibility of lectins from <i>Allium sativum</i> (garlic) and <i>Allium ursinum</i> (wild garlic) as inhibitors of SARS-CoV-2 entry. The information spectrum metho... |
40003109 | Entropy Production in a System of Janus Particles. | Entropy production is a key descriptor of out-of-equilibrium behavior in active matter systems, providing insights into both single-particle dynamics and emergent collective phenomena. It helps determine transport coefficients and phoretic velocities and serves as a crucial tool for understanding collective phenomena s... |
40002691 | Asiaticoside-Loaded Multifunctional Bioscaffolds for Enhanced Hyperglycemic Wound Healing. | The review explores the potential of asiaticoside-loaded bioscaffolds to improve the management of hyperglycemic wounds, particularly diabetic foot ulcers (DFUs). Asiaticoside, sourced from <i>Centella asiatica</i>, possesses properties that address DFUs' healing challenges: insufficient angiogenesis, persistent inflam... |
40001469 | Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction. | Mechano-signal transduction is a process in which cells perceive extracellular mechanical signals, convert them into intracellular biochemical signals, and produce a response. Integrins are cell surface receptors that sense the extracellular mechanical cues and bind to the extracellular matrix (ECM). This binding induc... |
40001468 | Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential. | Chronic pain and mental health disorders, such as depression and anxiety, frequently co-occur and share underlying mechanisms involving neuronal excitability and synaptic transmission. The inwardly rectifying potassium channel 4.1 (Kir4.1), predominantly expressed in glial cells, is crucial for maintaining extracellula... |
39997697 | From Pathophysiology to Practice: Evolving Pharmacological Therapies, Clinical Complications, and Pharmacogenetic Considerations in Portal Hypertension. | <b>Background:</b> Portal hypertension is a major complication of chronic liver diseases, leading to serious issues such as esophageal variceal bleeding. The increase in portal vein pressure is driven by both an organic component and a functional component, including tonic contraction of hepatic stellate cells. These p... |
39996970 | Beyond Traditional Lateral Flow Assays: Enhancing Performance Through Multianalytical Strategies. | Multiplex lateral flow assays are one of the greatest advancements in the world of rapid diagnostics, achieving the performance of several tests in one. These tests meet the basic requirements of increasing ease of use, low detection limit, and high specificity, as they combine the use of novel strategies, such as the ... |
39996631 | Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances. | There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution of this has not yet been achieved at an appropriate level for commercialization. Advanced perception is necessary for the design and synthesis of suitable materials, such as PVA-based hydrogel for bi... |
39978899 | Controlled green heterogenous functionalization of cellulose via strategic reaction system design. | Green chemical modification of cellulose presents a unique chemical challenge, especially from the vantage point of sustainable development that is favored by the use of wood fibers, heterogeneous conditions, and reactants and solvents of biobased relevance. However, heterogeneous conditions imply that cellulose is a s... |
39958485 | Molecular Design Strategies to Enhance the Electroresponse of Polyelectrolyte Brushes: Effects of Charge Fraction and Chain Length Dispersity. | Polyelectrolyte brushes are functional surface coatings that react to external stimuli. The response of these brushes in electric fields is nearly immediate as the field acts directly on the charges in the polyion, while the response to bulk stimuli such as temperature, acidity, and ionic composition is intrinsically c... |
39942617 | Harnessing Ultrasonic Technologies to Treat <i>Staphylococcus Aureus</i> Skin Infections. | The rise of antibiotic-resistant <i>Staphylococcus aureus</i> strains, particularly MRSA, complicates the management of skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat <i>S. aureus</i>-driven skin infections and prevent progression to biofilm formation ... |
39942618 | Facile Growing of Ni-MOFs on Ni Foam by Self-Dissociation Strategy for Electrochemical Energy Storage. | Metal-organic frameworks (MOFs) with redox metal centers have come into view as potential materials for electrochemical energy storage. However, the poor electrical conductivity largely impedes the potentiality of MOFs to construct high-performance electrodes in supercapacitors. In this work, a self-dissociation strate... |
39942611 | Efficient and Selective Extraction of Prenylated Flavonoids from <i>Sophora flavescens</i> Using Ultrasound-Assisted Hydrophobic Ionic Liquid and Characterization of Extraction Mechanism. | As a secondary metabolite with vigorous pharmacological activity (antitumor), prenylated flavonoids in <i>Sophora flavescens</i> (PFS) have great potential to be transformed into lead compounds. Its extraction has attracted more and more attention. Conventional organic solutions cannot selectively extract PFS and then ... |
39942606 | The Role of Orthobunyavirus Glycoprotein Gc in the Viral Life Cycle: From Viral Entry to Egress. | Orthobunyavirus refers to the virus members within the Genus Orthobunyavirus, which is the largest virus genus in the Family Peribunyaviridae and even Class Bunyaviricetes. To date, over 130 species of Orthobunyaviruses have been identified worldwide. Orthobunyaviruses mainly infect arthropods, while some species are c... |
39942604 | A Study on the Iodine Vapor Adsorption Performance and Desorption Behavior of HKUST-1 with Varying Particle Sizes. | Iodine is one of the key elements that must be removed from the off-gas systems of nuclear fuel reprocessing. This study systematically investigates the iodine vapor adsorption performance of the metal-organic framework (MOF) material HKUST-1(1-(2-methyl-4-(2-oxopyrrolidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2... |
39942596 | Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme. | The COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. The papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage and immune evasion, making it a prime target for therapeutic intervention. Numerous compounds have ... |
39942180 | Multi-Responsive Amphiphilic Hyperbranched Poly[(2-dimethyl aminoethyl methacrylate)-co-(benzyl methacrylate)]copolymers: Self-Assembly and Curcumin Encapsulation in Aqueous Media. | In this study, we report the synthesis of amphiphilic hyperbranched poly[(2-dimethylaminoethyl methacrylate)-co-(benzyl methacrylate)] statistical copolymers with two different stoichiometric compositions using the reversible addition-fragmentation chain transfer polymerization (RAFT) technique. The selection of monome... |
39941956 | Research Progress Regarding Psychrotrophic <i>Pseudomonas</i> in Aquatic Products: Psychrophilic Characteristics, Spoilage Mechanisms, Detection Methods, and Control Strategies. | Aquatic products are an important part of the human diet, but they are easily contaminated by <i>Pseudomonas</i> spp., which leads to food deterioration and economic loss. In this paper, the main characteristics of psychrotrophic <i>Pseudomonas</i> in aquatic products are reviewed, including its growth adaptation mecha... |
39941745 | Personalized Immunity: Neoantigen-Based Vaccines Revolutionizing Hepatocellular Carcinoma Treatment. | Hepatocellular carcinoma (HCC), the most prevalent form of primary liver cancer, presents significant therapeutic challenges due to its molecular complexity, late-stage diagnosis, and inherent resistance to conventional treatments. The intermediate to low mutational burden in HCC and its ability to evade the immune sys... |
39940724 | The Role of Genetic Resistance in Rice Disease Management. | Rice (<i>Oryza sativa</i>) is a crucial staple crop for global food security, particularly in Asia. However, rice production faces significant challenges from various diseases that can cause substantial yield losses. This review explores the role of genetic resistance in rice disease management, focusing on the molecul... |
39940720 | Biomass-Derived Nanoporous Carbon Honeycomb Monoliths for Environmental Lipopolysaccharide Adsorption from Aqueous Media. | After undergoing biological treatment, wastewater still contains substances with endotoxic activity, such as lipopolysaccharide. However, due to the increasing practice of treating wastewater to make it suitable for drinking (potable reuse), the removal of these endotoxic active materials is crucial. These substances c... |
39940489 | Influence of Process Aids on Solid-Liquid Interfacial Properties of Three-Component Hydroxyl-Terminated Polybutadiene Propellants. | The effect of the process aid "OPS" on the rheological properties of hydroxyl-terminated polybutadiene propellant was investigated by formulating different components of high-solid-content slurry, and the change in slurry viscosity with shear rate, surface morphology of solid-phase particles, and contact angle of the r... |
39940264 | Astragalin Exerted Hypoglycemic Effect by Both Inhibiting α-Glucosidase and Modulating AMPK Signaling Pathway. | <h4>Background</h4>The hypoglycemic activity of mulberry leaf polyphenols has been widely studied, while its mechanism of action needs further elucidation.<h4>Methods</h4>The inhibitory activity mechanism of astragalin on α-glucosidase was investigated with a combination of multispectroscopic techniques and molecular d... |
39940154 | Deep Learning Design for Loss Optimization in Metamaterials. | Inherent material loss is a pivotal challenge that impedes the development of metamaterial properties, particularly in the context of 3D metamaterials operating at visible wavelengths. Traditional approaches, such as the design of periodic model structures and the selection of noble metals, have encountered a plateau. ... |
39940146 | Synthesis of Electrocatalytic Tungsten Carbide Nanoparticles by High-Pressure and High-Temperature Treatment of Organotungsten Compounds. | Metal-organic framework (MOF)-derived carbon, which contains metal nanoparticles embedded in a carbon matrix, is becoming an important group of catalysts. We report the synthesis of tungsten carbide-carbon nanocomposites using a similar concept, i.e., by pyrolysis of organotungsten compounds under high-temperature and ... |
39936968 | Crosstalk Between Abiotic and Biotic Stresses Responses and the Role of Chloroplast Retrograde Signaling in the Cross-Tolerance Phenomena in Plants. | In the natural environment, plants are simultaneously exposed to multivariable abiotic and biotic stresses. Typical abiotic stresses are changes in temperature, light intensity and quality, water stress (drought, flood), microelements availability, salinity, air pollutants, and others. Biotic stresses are caused by oth... |
39935893 | Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair. | Spinal cord injury (SCI) is significantly hampered by an inflammatory microenvironment, prompting continued efforts in drug development to address inflammation. Research shows that quercetin (Que) exhibits excellent performance in reducing inflammation and neuroprotection. However, its application is limited by poor so... |
39926555 | Adsorptive Effect of Corn Silk-Loaded Nickel Oxide and Copper Oxide Nanoparticles for Elimination of Ciprofloxacin from Wastewater. | Ciprofloxacin (CIP) is one of the most reported antibiotic pollutants in hospital and industrial wastewater systems. The inclusion of nanosized transition metal oxides in adsorbent materials is able to improve the affinity and aqueous phase uptake of CIP from water. In this study, we report for the first time composite... |
39926536 | Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV-1 DNA Polymerase Inhibitors. | The reintroduction of the pseudorabies virus (PRV) has led to the emergence of epidemics in some pig farms in China, resulting in significant economic losses. Moreover, the number of human infections with PRV has increased. Therefore, research into the prevention and treatment of PRV strains is imperative. In this work... |
39926522 | Revealing the Role of <i>X</i> <sub>12</sub> <i>Y</i> <sub>12</sub> Nanocages (<i>X</i> = B, In; <i>Y</i> = N, Sb) in NH<sub>3</sub> Gas Adsorption: toward Gas Sensor Application. | The dangers of ammonia gas (NH<sub>3</sub>) to human health must be considered. Exposure to NH<sub>3</sub> gas can have several adverse effects, including harm to the skin; irritation of the eyes, nose, and throat; and damage to the respiratory system. New materials are being developed for use in gas sensors to mitigat... |
39926499 | Synthesis and Crystal Structure of Zn<sub>3</sub>(OAc)<sub>8</sub>[EMIM]<sub>2</sub>, a Novel Ionic Compound with Isolated Homoleptic Trinuclear Metal Clusters. | We synthesized and characterized a novel anhydrous zinc(II) aceto 1-ethyl-3-methylimidazolium (EMIM) coordination compound with the simplified empirical formula Zn<sub>3</sub>(OAc)<sub>8</sub>[EMIM]<sub>2</sub>. The title compound is structurally related to recently reported Mn<sub>4</sub>(OAc)<sub>10</sub>[EMIM]<sub>2... |
39917618 | Chemical characterization and encapsulation of <i>Ganoderma pfeifferi</i> extract with cytotoxic properties. | Mushrooms of the genus <i>Ganoderma</i> are known for diverse biological activities, demonstrated both traditionally and experimentally. Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration of the most active components in different species or genotypes, new... |
39917312 | Exploring the antiviral potential of shikimic acid against Chikungunya virus through network pharmacology, molecular docking, and <i>in vitro</i> experiments. | Chikungunya virus (CHIKV) is an arbovirus that can lead to chronic arthritis and significantly diminish the quality of life of patients. Given the expanding global prevalence of CHIKV and the absence of specific antiviral therapies, there is an urgent need to explore effective treatment options. This study aimed to eva... |
39916960 | Feature selection enhances peptide binding predictions for TCR-specific interactions. | <h4>Introduction</h4>T-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. Accurate prediction of peptide binding to TCRs is essential for advancing immunotherapy, vaccine design, and understanding mecha... |
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