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40060922 | Donor-acceptor engineering of a triplet-exciton-optimized MOF photocatalyst for efficient singlet oxygen-mediated oxidation. | The exploration of photocatalysts (PCs) for efficient singlet oxygen (<sup>1</sup>O<sub>2</sub>)-based photocatalytic oxidation is critical and challenging. Herein, a new series of donor-acceptor metal-organic frameworks (D-A MOFs) are constructed through the engineering of the D-A system, and investigated as PCs for t... |
40017762 | The Multifaceted Role of 3D Printed Conducting Polymers in Next-Generation Energy Devices: A Critical Perspective. | The increasing human population is leading to growing consumption of energy sources which requires development in energy devices. The modern iterations of these devices fail to offer sustainable and environmentally friendly answers since they require costly equipment and produce a lot of waste. Three-dimensional (3D) p... |
40008090 | A novel platform for engineered AAV-based vaccines. | Engineering of adeno-associated virus (AAV) capsids allowed for the development of gene therapy vectors with improved tropism and enhanced transduction efficiency. Capsid engineering can also be used to adapt the AAV technology for applications outside gene therapy. Here, we investigated modified AAV capsids as scaffol... |
40006653 | Insights into IAV Replication and Lipid Metabolism in Suspension-Adapted MDCK-STAT1-KO Cells. | <h4>Objectives</h4>The industrial production of influenza vaccines is facing significant challenges, particularly in improving virus production efficiency. Despite advances in cell culture technologies, our understanding of the production characteristics of high-yield suspension cell lines remains limited, thereby impe... |
40006515 | Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review. | The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the oral cavity, offering an alternative to enteral administration by bypassing the harsh gastrointestinal environment and hepatic first-pass metabolism. This ... |
40004449 | Genome-Wide Identification and Characterization of the <i>Pirin</i> Gene Family in <i>Nicotiana benthamiana</i>. | <b>Background</b>: Pirins are nuclear cupin proteins, one of several gene families within the plant cupin superfamily. However, the identification and functional analysis of Pirin proteins in <i>Nicotiana benthamiana</i> have not been explored. <b>Methods</b>: In this study, genome-wide analysis identifying NbPirin gen... |
39996627 | Facile Synthesis of Bioactive Silver Nanocomposite Hydrogels with Electro-Conductive and Wound-Healing Properties. | Bioactive metal and metal oxide-based nanocomposite hydrogels exhibit significant antibacterial properties by interacting with microbial DNA and preventing bacterial replication. They offer potential applications as coating materials for human or animal skin injuries to prevent microbial growth and promote healing. In ... |
39978889 | Antimicrobial chitosan-based hydrogels: A novel approach to obtain sanitizers. | The study presents novel hydrogels obtained by crosslinking chitosan with both furfural and glutaraldehyde via dynamic imine bonds. Scanning electron microscopy confirmed the formation of porous networks with a mean diameter of the pores between 15 and 35 μm, while the supramolecular characterization by polarized optic... |
39958230 | Potential utility of miRNAs derived from pleural fluid extracellular vesicles to differentiate between benign and malignant pleural effusions. | <h4>Background</h4>Cytological examination is of suboptimal sensitivity but high specificity for the diagnosis of malignant pleural effusions (MPEs). Pleural fluid extracellular vesicles (PFEVs) are enriched with disease-specific microRNAs (miRNAs) which may improve the diagnostic yield for MPE. Our previous study demo... |
39949364 | Comprehensive Assessment of Rapeseed Meal as a Fish Meal Substitute in Hybrid Sturgeon (<i>Acipenser schrenckii</i> ♀ × <i>Acipenser baerii</i> ♂) Diets: Impacts on Growth Performance, Body Composition, Immunological Responses, Intestinal Histology, and Inflammatory Response. | This study aimed to assess the impact of incorporating rapeseed meal (RM) as a partial substitute for fish meal (FM) in the diet of cultured hybrid sturgeon (<i>Acipenser schrenckii</i> ♀ × <i>Acipenser baerii</i> ♂). A total of 450 juvenile hybrid sturgeon with similar weights were randomly assigned to five dietary gr... |
39947987 | Steering CO<sub>2</sub> electroreduction to hydrocarbons over 2D thiol-based conductive metal-organic framework. | Almost all of Cu<sub>x</sub>S compounds only produce the simple two-electron transferred products CO and HCOOH but it remains a large challenge to obtain the multiple-electron transferred hydrocarbon products in electrocatalytic CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR). Moreover, identifying the distinct co... |
39946964 | Supporting cell involvement in cochlear damage and repair: Novel insights from a quantitative analysis of cyclodextrin-induced ototoxicity in mice. | The cochlea is vulnerable to various pathological conditions, with sensory cells typically being the primary targets of damage. However, supporting cells also experience significant impacts. Despite their critical role in maintaining the structural and functional integrity of the sensory epithelium, the supporting cell... |
39943077 | Comparison of the Anesthetic Effects of Alfaxalone Combined with Xylazine or Dexmedetomidine in Captive Formosa Serows (<i>Capricornis swinhoei</i>). | Formosan serows are an endemic species in Taiwan. Alfaxalone, a γ-aminobutyric acid<sub>A</sub> agonist, induces or maintains anesthesia in various veterinary species with reported potential adverse effects of respiratory depression and tachycardia. α2-Adrenoceptor agonists exert sedative and muscle relaxation effects,... |
39942882 | Roles and Regulations of Acid Invertases in Plants: Current Knowledge and Future Perspectives. | Acid invertases (Ac-Invs) are crucial enzymes in plant physiology, regulating sucrose metabolism and hydrolyzing sucrose into glucose and fructose. These sugars serve not only as energy sources and structural components but also as signaling molecules, influencing diverse developmental processes, including seed and fru... |
39942588 | Rapid Detection of Alpha-Fetoprotein (AFP) with Lateral Flow Aptasensor. | We present a lateral flow aptasensor for the visual detection of alpha-fetoprotein (AFP) in human serum. Leveraging the precise molecular recognition capabilities of aptamers and the distinct optical features of gold nanoparticles, a model system utilizing AFP as the target analyte, along with a pair of aptamer probes,... |
39942587 | The Pharmaceutical Industry in 2024: An Analysis of the FDA Drug Approvals from the Perspective of Molecules. | The U.S. Food and Drug Administration (FDA) has authorized 50 new drugs in 2024, which matches the average figure for recent years (2018-2023). The approval of 13 monoclonal antibodies (mAbs) sets a new record, with these molecules accounting for more than 25% of all drugs authorized this year. Three proteins have been... |
39942168 | Recent Advances in Barnacle-Inspired Biomaterials in the Field of Biomedical Research. | As a marine fouling organism, barnacles secrete a cement whose proteins self-assemble into stable nanofibers, conferring exceptional underwater adhesion and curing properties. The barnacle cement proteins (BCPs) are of significant interest in biomedicine due to their adhesiveness, water resistance, stability, and bioco... |
39942159 | <i>ι</i>-Carrageenan Manganese Oxide Bionanocomposites as a Promising Solution to Agricultural Challenges. | Agriculture faces numerous challenges: infectious diseases through phytopathogens and soil nutrient deficiencies hinder plant growth, reducing crop yields. Biopolymer nanocomposites offer promising solutions to these challenges. In this work, we synthesize and characterize novel bionanocomposites (<i>ι</i>-CG-Mn) of ma... |
39940692 | Double Peptide-Functionalized Carboxymethyl Chitosan-Coated Liposomes Loaded with Dexamethasone as a Potential Strategy for Active Targeting Drug Delivery. | Liposomes are intensively used as nanocarriers for biology, biochemistry, medicine, and in the cosmetics industry and their non-toxic and biocompatible nature makes these vesicles attractive systems for biomedical applications. Moreover, the conjugation of specific ligands to liposomes increases their cellular uptake a... |
39940689 | Genome-Wide Identification and Analysis of Carbohydrate-Binding Modules in <i>Colletotrichum graminicola</i>. | <i>Colletotrichum graminicola</i> is the causative agent of both maize stem rot and leaf blight, which are among the most damaging diseases affecting maize. Carbohydrate-binding modules (CBMs) are protein domains that lack catalytic activity and are commonly found alongside carbohydrate-hydrolyzing enzymes in fungi. A ... |
39940678 | In Silico and In Vivo Evaluation of Novel 2-Aminobenzothiazole Derivative Compounds as Antidiabetic Agents. | Currently, there are several drugs used for the treatment of type 2 diabetes (T2D); however, all of them have adverse effects. Benzothiazoles have a broad spectrum of biological activities such as antidiabetic. This study aimed to evaluate in silico and in vivo two series of 2-aminobenzothiazole derivatives linked to i... |
39940673 | Integrins as Key Mediators of Metastasis. | Metastasis is currently becoming a major clinical concern, due to its potential to cause therapeutic resistance. Its development involves a series of phases that describe the metastatic cascade: preparation of the pre-metastatic niche, epithelial-mesenchymal transition, dissemination, latency and colonization of the ne... |
39940483 | Tuning the Compatibilizer Content and Healing Temperature in Thermally Mendable Polyamide 6/Cyclic Olefin Copolymer Blends. | This study presents the formulation and comprehensive characterization of compatibilized polyamide 6 (PA6)/cyclic olefin copolymer (COC) blends with the aim of developing a self-healing matrix for thermoplastic structural composites. Rheological analysis highlighted the compatibilizing effect of ethylene glycidyl metha... |
39940481 | Direct Ink Writing and Photocrosslinking of Hydroxypropyl Cellulose into Stable 3D Parts Using Methacrylation and Blending. | Two 50% solid content solutions of methacrylated hydroxypropyl cellulose (MAHPC) with respective substitution degrees of 1.85 ± 0.04 (L_MAHPC) and 2.64 ± 0.04 (H_MAHPC) were screened for rheological properties, photocrosslinking kinetics and printability in relevance to direct ink writing (DIW). Photo-rheological and p... |
39940474 | Comprehensive Review: Optimization of Epoxy Composites, Mechanical Properties, & Technological Trends. | Epoxy composites play a crucial role in modern materials technologies, with their exceptional properties such as high strength and thermal and chemical resistance, making them ideal for a wide range of industrial applications, including aerospace, automotive, construction, and energy. This review article provides a com... |
39940255 | The Olive Oil Phenolic <i>S</i>-(-)-Oleocanthal Suppresses Colorectal Cancer Progression and Recurrence by Modulating SMYD2-EZH2 and c-MET Activation. | <b>Background/Objectives</b>: Colorectal cancer (CRC) is the third most common cancer in the US and the second leading cancer-associated mortality cause. Available CRC therapies achieve modest outcomes and fail to prevent its recurrence. Epidemiological studies indicated that the Mediterranean diet rich in olive oil re... |
39940139 | A Colorimetric and Fluorescent Dual-Mode Sensor Based on a Smartphone-Assisted Laccase-like Nanoenzyme for the Detection of Tetracycline Antibiotics. | A copper-based nanoenzyme (Cu-BL) co-modified by L-L-lysine and 2-2-amino terephthalic acid has laccase-like activity and fluorescence characteristics. Based on this, a colorimetric and fluorescent dual-mode sensor was developed to visually and quantitatively detect tetracycline antibiotics (TCs), including tetracyclin... |
39940140 | Investigating Benzoic Acid Derivatives as Potential Atomic Layer Deposition Inhibitors Using Nanoscale Infrared Spectroscopy. | Area-selective atomic layer deposition (AS-ALD) is a technique utilized for the fabrication of patterned thin films in the semiconductor industry due to its capability to produce uniform and conformal structures with control over thickness at the atomic scale level. In AS-ALD, surfaces are functionalized such that only... |
39940137 | <i>Iota</i>-Carrageenan/Chitosan Nanoparticles via Coacervation: Achieving Stability for Tiny Particles. | This study investigated the influence of parameters such as pH condition, polyelectrolyte concentration, polymer ratio, and order of addition of the commercial polyelectrolytes chitosan and <i>iota</i>-carrageenan (ι-carrageenan) on the formation of polymeric nanoparticles in suspension (coacervates). A preliminary pur... |
39936962 | Cellular Systems for Colorectal Stem Cancer Cell Research. | Oncological diseases consistently occupy leading positions among the most life-threatening diseases, including in highly developed countries. At the same time, the second most common cause of cancer death is colorectal cancer. The current level of research shows that the development of effective therapy, in this case, ... |
39926542 | Design of a Multi-Epitope Vaccine against the Glycoproteins of Newcastle Disease Virus by Using an Immunoinformatics Approach. | Newcastle disease (ND) causes major economic losses in poultry farming in Madagascar and many other countries. Previously, vaccines based on attenuated or inactivated Newcastle disease viruses (NDV) have been effective against this disease. However, their efficacy has declined due to viral mutations over time. To addre... |
39926435 | Cost Estimation of the Production of MIL-100(Fe) at Industrial Scale from Two Upscaled Sustainable Synthesis Routes. | Understanding the impact of MOF synthesis conditions on the production cost is vital in order to have a competitive product with a view toward industrial applications. Here, considering the benchmark mesoporous iron(III) trimesate MIL-100(Fe) as a prototypical example, we show that the production cost can reach <30 $/k... |
39926159 | A novel mode of histone-like protein HupB regulating <i>Sinorhizobium meliloti</i> cell division through lysine acetylation. | HU, a small, basic histone-like protein, binds to bacterial genomic DNA, influencing DNA conformation, replication, and transcription. Its acetylation is a key post-translational modification affecting its DNA-binding activity. The role of HU acetylation in regulating cell division through the cell cycle regulatory sys... |
39925713 | Supramolecular peptide hydrogel epitope vaccine functionalized with CAR-T cells for the treatment of solid tumors. | Chimeric antigen receptor T-cell (CAR-T) therapy, which benefits from the perfect combination of gene editing techniques and antibody engineering, has shown outstanding clinical efficacy in hematological malignancies. Solid tumors present the next challenge due to their extremely complicated microenvironment and struct... |
39916851 | Optimization of energy output from PVT-PCM systems with emerging metal-organic frameworks phase change materials. | Existing literature has largely overlooked the challenge of providing continuous electrical and thermal energy solely through solar power, especially in rural areas with diverse energy demands. The current study investigated two configurations of photovoltaic thermal-phase change material systems: system A, which featu... |
39912098 | Construction and evaluation of <i>Brassica rapa</i> orphan genes overexpression library. | Orphan genes (<i>OGs</i>) are crucial for species-specific characteristics and stress responses and are restricted to a specific taxon. However, their functions within particular species are poorly understood. Previous research identified <i>OGs</i> in <i>Brassica rapa</i> (<i>BrOGs</i>). In this study, the <i>BrOGs</i... |
39911864 | Recent advances in nanotechnology for Parkinson's disease: diagnosis, treatment, and future perspectives. | Parkinson's disease is a progressive neurodegenerative disease that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, and surgical methods.... |
39911822 | Natural killer cell engagers for cancer immunotherapy. | This review article explores the rapidly evolving field of bi-, tri-, and multi-specific NK cell engagers (NKCEs), highlighting their potential as a cutting-edge approach in cancer immunotherapy. NKCEs offer a significant advancement over conventional monoclonal antibodies (mAbs) by enhancing Antibody-Dependent Cellula... |
39911816 | Innovative applications of advanced nanomaterials in cerebrovascular imaging. | Cerebrovascular imaging is essential for the diagnosis, treatment, and prognosis of cerebrovascular disease, including stroke, aneurysms, and vascular malformations. Conventional imaging techniques such as MRI, CT, DSA and ultrasound have their own strengths and limitations, particularly in terms of resolution, contras... |
39911715 | Deep learning in microbiome analysis: a comprehensive review of neural network models. | Microbiome research, the study of microbial communities in diverse environments, has seen significant advances due to the integration of deep learning (DL) methods. These computational techniques have become essential for addressing the inherent complexity and high-dimensionality of microbiome data, which consist of di... |
39911714 | Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals. | The family Circoviridae includes the genera Circovirus and Cyclovirus. Cycloviruses have been found in serum samples from chronic HBV, HCV, or HIV-infected individuals as well as asymptomatic blood donors. However, research on cycloviruses is relatively limited. We used viral metagenomics to mine, analyze, and visualiz... |
39911658 | Improving the <i>N</i>-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297. | Monoclonal antibodies are crucial recombinant biopharmaceuticals, with <i>N</i>-glycosylation at Asn297 essential for their functionality. Plants are increasingly used for antibody production, achieving high expression levels and enabling glycoengineering to produce homogenous human-like <i>N</i>-glycan structures. How... |
39911388 | Current status and future prospects of molecular imaging in targeting the tumor immune microenvironment. | Molecular imaging technologies have significantly transformed cancer research and clinical practice, offering valuable tools for visualizing and understanding the complex tumor immune microenvironment. These technologies allow for the non-invasive examination of key components within the tumor immune microenvironment, ... |
39911386 | Applications of cell penetrating peptide-based drug delivery system in immunotherapy. | Cell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating unnatural amino acids, and lipid conjugation. These properties have made t... |
39911370 | 3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation. | Orthotopic implantation <i>in vivo</i> is the ultimate target of tissue-engineering organoids research, aiming to achieve sustaining survival after implantation. However, the limited representation of a complex microenvironment in implanted accepter hampers a comprehensive understanding of long-term maintenance of tiss... |
39911308 | In silico design of an epitope-based vaccine ensemble for fasliolopsiasis. | <h4>Introduction</h4>Fasciolopsiasis, a food-borne intestinal disease is most common in Asia and the Indian subcontinent. Pigs are the reservoir host, and fasciolopsiasis is most widespread in locations where pigs are reared and aquatic plants are widely consumed. Human infection has been most commonly documented in Ch... |
39911245 | Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosis. | <h4>Background</h4>Infected pancreatic necrosis (IPN) represents a severe complication of acute pancreatitis, commonly linked with mortality rates ranging from 15% to 35%. However, the present mortality prediction tools for IPN are limited and lack sufficient sensitivity and specificity. This study aims to develop and ... |
39906645 | Injectable iodine-containing peptide hydrogel for treatment of MRSA infection. | Iodine is widely acknowledged for its potent antimicrobial properties. However, its clinical utility is often hampered by its unsatisfactory stability, uncontrolled release of active iodine and toxicity in moist environments. In this study, we report a novel iodine-containing hydrogel (I<sub>2</sub>@Nap-FFGP) designed ... |
39906384 | Uncovering the potent antimicrobial activity of squaramide based anionophores - chloride transport and membrane disruption. | Antimicrobial resistance (AMR) - often referred to as a silent pandemic, is at present the most serious threat to medicine, and with constantly emerging resistance to novel drugs, combined with the paucity of their development, is likely to worsen. To circumvent this, supramolecular chemists have proposed the applicabi... |
39886611 | Gum Arabic induced assembly of cellulose nanocrystals in aqueous media. | Entropy-driven assembly of nematic liquid-crystal phases of cellulose nanocrystals (SCNCs) in aqueous suspensions results in the emergence of a cholesteric liquid crystalline phase (N* phase). We report that a solvated, non-adsorbing, highly branched natural polysaccharide, Gum Arabic (GA), strongly affects the assembl... |
39886441 | Tunable structural rearrangement in Cu cluster assemblies through linker and solvent alterations. | The scarcity of approaches to assembling copper nanoclusters (Cu NCs) has restricted advancements in Cu NCs research, largely due to stability challenges of the individual NCs. By utilizing the structural adaptability of Cu NCs, we systematically investigate how variations in organic linkers and solvents affect the clu... |
39886440 | Exploiting spatial isomerism to modulate the assembled phase and rheological response of compositionally identical sugar-based surfactants. | For decades, extensive surfactant libraries have been developed to meet the requirements of downstream applications. However, achieving functional diversity has traditionally demanded a vast array of chemical motifs and synthetic pathways. Herein, a new approach for surfactant design based on structural isomerism is ut... |
39874777 | Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography. | In the context of molecular imaging, the present work explores an innovative platform made of lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, the dynamics of gas bubbles generation and cavitation under insonation with either pristine or lipid-coated nanoc... |
39871960 | Fu Tu Sheng Jin Rehabilitation Formula Mitigate Airway Inflammation, Mucus Secretion and Immune Dysfunction Induced by SARS-CoV-2 Spike Protein. | <h4>Objective</h4>To evaluate the effects of Fu Tu Sheng Jin Rehabilitation Formula (FTSJRF) on airway inflammation, mucus secretion, and immunoreaction in a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein-induced mouse model.<h4>Methods</h4>Forty-two mice were randomly divided into seven gro... |
39867958 | Lanthanide-tetrazine probes for bio-imaging and click chemistry. | The blood-brain-barrier prevents many imaging agents and therapeutics from being delivered to the brain that could fight central nervous system diseases such as Alzheimer's disease and strokes. However, techniques such as the use of stapled peptides or peptide shuttles may allow payloads through, with bioconjugation ac... |
39867313 | A Multifunctional MIL-101-NH<sub>2</sub>(Fe) Nanoplatform for Synergistic Melanoma Therapy. | <h4>Background</h4>Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence and metastasis. Combination therapy has emerged as an effective approach to improve treatment outcomes.<h4>Methods</h4>In this study, we developed a multifunctional nanoplatform, MIL@D... |
39867306 | Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study. | <h4>Purpose</h4>The main purpose of the study was the formulation development of nanogels (NHs) composed of chondroitin sulfate (CS) and low molecular weight chitosan (lCH), loaded with a naringenin-β-cyclodextrin complex (NAR/β-CD), as a potential treatment for early-stage diabetic retinopathy.<h4>Methods</h4>Differen... |
39866858 | Rapid introgression of the clubroot resistance gene <i>CRa</i> into cabbage skeleton inbred lines through marker assisted selection. | Clubroot, caused by <i>Plasmodiophora brassicae</i>, is a globally pervasive soil-borne disease that poses a significant challenge primarily in cruciferous crops. However, the scarcity of resistant materials and the intricate genetic mechanisms within cabbage present major obstacles to clubroot resistance (CR) breeding... |
39864143 | Carbohydrate-active enzyme-catalyzed stereoselective glycosylation of complex natural product glycosides. | Natural products and their derivatives are precious resources with extensive applications in various industrial fields. Enzymatic glycosylation is an efficient approach for chemical structure diversification and biological activity alternation of natural products. Herein, we reported a stereoselective glycosylation of ... |
39855502 | Development of a nasal spray based on cyclodextrin/hydrophobically-modified hydroxypropyl-methyl cellulose for the prevention of viral respiratory infections. | The work aims to develop mucoadhesive and thermo-responsive in situ gelling systems, using hydrophobically-modified hydroxypropyl-methyl cellulose (Sangelose, SG) and beta-cyclodextrin (β-CD) derivatives, for preventing viral respiratory infections. Eight SG/CD systems with varying CD concentrations were evaluated for ... |
39855466 | Investigating the binding dynamics and stability of bovine serum albumin with antibiotics with acridinedione dye. | Exploring the energetics and bimolecular interaction of bovine serum albumin (BSA) with various classes and generations of antibiotics in the absence and presence of a resorcinol based acridinedione dye (ADR1) were carried out. The binding stability of BSA-antibiotic complexes decreases on the introduction of ADR1 dye ... |
39855415 | Novel anionic functionalized magnetic β-cyclodextrin composites with excellent adsorption capacity for moxifloxacin and wide pH adaptive adsorption capability for copper ion. | Antibiotics and heavy metals pose severe risks to human health and ecological environment. Therefore, developing a multifunctional adsorbent to remove these contaminants from wastewater is an urgent need. Herein, novel anionic sulfonic acid groups functionalized magnetic β-cyclodextrin (β-CD) composites (FCD@AA) were s... |
39855414 | Polydopamine modified coconut shell biochar decorated with ZIF-8 for improved adsorption of malachite green and rhodamine B from aqueous solution. | Although various biochars from different biomass materials have been developed to remediate dye-contaminated environments, the removal capabilities of pristine biochar for dyes urgently require further enhancement due to insufficient surface adsorption sites. To introduce more adsorption sites, this work proposes a sim... |
39855299 | Integrated multi-omics reveals the Bacillus amyloliquefaciens BA40 against Clostridium perfringens infection in weaned piglets. | <h4>Introduction</h4>Clostridium perfringens (C. perfringens) can cause necrotic enteritis and higher mortality rates in piglets, by impairing the intestinal barrier function. Bacillus amyloliquefaciens 40 (BA40) has showed potential ability to reduce C. perfringens infections, but the mechanisms responsible for its ef... |
39855072 | Enhancement of Oryzanol application by constructing modified β-CD inclusion complex and polycaprolactone-chitosan electrospun fiber membranes: Perspectives on wound dressings and grape preservation. | Oryzanol has a variety of physiological activities and is widely used in food and medicine. However, its utilization form and bioavailability are limited by poor solubility and photothermal stability. In this paper, an inclusion complex (IC) was prepared by modifying β-cyclodextrin as a molecular carrier to encapsulate... |
39850662 | Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach. | Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at the price of the environment. Due to the rise in illnesses, Industry 6.0 calls for a renewed dedication to sustainability with latest technologies. Focused researc... |
39850549 | Probing structural requirements for thiazole-based mimetics of sunitinib as potent VEGFR-2 inhibitors. | Novel thiazole analogs 3a, 3b, 4, 5, 6a-g, 8a, 8b, 9a-c, 10a-d and 11 were designed and synthesized as molecular mimetics of sunitinib. <i>In vitro</i> antitumor activity of the obtained compounds was investigated against HepG2, HCT-116, MCF-7, HeP-2 and HeLa cancer cell lines. The obtained data showed that compounds 3... |
39848687 | Leveraging mRNA technology for antigen based immuno-oncology therapies. | The application of messenger RNA (mRNA) technology in antigen-based immuno-oncology therapies represents a significant advancement in cancer treatment. Cancer vaccines are an effective combinatorial partner to sensitize the host immune system to the tumor and boost the efficacy of immune therapies. Selecting suitable t... |
39845720 | Maturing conditions of bimetallic nanocomposites as a new factor influencing Au-Ag synergism and impact of Cu(II) and/or Fe(III) on luminescence. | Gold-silver synergism has been well documented in many scientific works dealing with luminescent nanostructures that are exploitable in biomedical and environmental application. Frequently, the ratio of Au : Ag in synthetic mixtures was varied to influence the extent of Au-Ag synergism of the resulting luminescent gold... |
39845195 | Exercise therapy facilitates neural remodeling and functional recovery post-spinal cord injury via PKA/CREB signaling pathway modulation in rats. | <h4>Background</h4>Neuronal structure is disrupted after spinal cord injury (SCI), causing functional impairment. The effectiveness of exercise therapy (ET) in clinical settings for nerve remodeling post-SCI and its underlying mechanisms remain unclear. This study aims to explore the effects and related mechanisms of E... |
39845116 | An electrically conductive dinuclear aluminium complex for the fabrication of a Schottky diode. | Electrical performances of a biphenyl-derived amido Schiff base ligand L and its dinuclear Al(iii) complex (complex 1) were investigated in a metal-semiconductor (MS) junction. Electrical studies revealed that complex 1 significantly enhanced the electrical conductivity and improved the characteristics of a Schottky ba... |
39845114 | Design strategies for organelle-selective fluorescent probes: where to start? | Monitoring physiological changes within cells is crucial for understanding their biological aspects and pathological activities. Fluorescent probes serve as powerful tools for this purpose, offering advantageous characteristics over genetically encoded probes. While numerous organelle-selective probes have been develop... |
39845110 | Functionalization of zeolite-encapsulated Cu<sub>5</sub> clusters as visible-light photoactive sub-nanomaterials. | The unique structural properties of zeolites make them ideal environments for encapsulating subnanometric metal clusters on their microporous channels and cavities, showing an enhanced catalytic performance. As a first step towards the functionalization of these clusters as photocatalysts as well, this work addresses t... |
39844926 | Mesenchymal stem cell-derived exosomes mitigate amyloid β-induced retinal toxicity: Insights from rat model and cellular studies. | Amyloid β (Aβ) has emerged as a pathophysiological driver in age-related macular degeneration (AMD), emphasizing its significance in the aetiology of this prevalent sight-threatening condition. The multifaceted nature of AMD pathophysiology, presumably involving diverse retinal cascades, corresponds with the complexity... |
39844866 | Core-Shell Structured Metal-Organic Frameworks for pH-Triggered Combination Photodynamic/Chemotherapy-Based Cancer Treatment. | The use of hypoxia-activated prodrugs is a promising strategy to address the limitations of photodynamic therapy (PDT) caused by a hypoxic tumor microenvironment. However, the controlled release of these hypoxia-activated prodrugs during PDT remains a challenge. In this study, we present a metal-organic framework (MOF)... |
39844867 | Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair. | Tendon/ligament-bone junctions (T/LBJs) are susceptible to damage during exercise, resulting in anterior cruciate ligament rupture or rotator cuff tear; however, their intricate hierarchical structure hinders self-regeneration. Multiphasic strategies have been explored to fuel heterogeneous tissue regeneration and inte... |
39844596 | Highly Accessible Electrocatalyst with <i>I</i><i>n Situ</i> Formed Copper-Cluster Active Sites for Enhanced Nitrate-to-Ammonia Conversion. | Ammonia synthesis via nitrate electroreduction is more attractive and sustainable than the energy-extensive Haber-Bosch process and intrinsically sluggish nitrogen electroreduction. Herein, we have designed a single-site Cu catalyst on hierarchical nitrogen-doped carbon nanocage support (Cu<sub>1</sub>/hNCNC) for nitra... |
39844526 | The splicing auxiliary factor OsU2AF35a enhances thermotolerance via protein separation and promoting proper splicing of OsHSA32 pre-mRNA in rice. | Heat stress significantly impacts global rice production, highlighting the critical need to understand the genetic basis of heat resistance in rice. U2AF (U2 snRNP auxiliary factor) is an essential splicing complex with critical roles in recognizing the 3'-splice site of precursor messenger RNAs (pre-mRNAs). The U2AF s... |
39844468 | Ester-Bearing Calix[<i>n</i>]phenoxazines: Side Chain Enhanced Recognition and Redox-Responsive Reversible Host-Guest System. | We report an enhanced recognition and redox-responsive reversible host-guest system based on ester-bearing calix[<i>n</i>]phenoxazines. The carbonyl groups, oriented toward the cavity, act as the extra binding sites to enhance the binding affinity, which is confirmed by NMR and FTIR experiments and single-crystal struc... |
39844345 | Tetrahedral Framework Nucleic Acid Relieves Sepsis-Induced Intestinal Injury by Regulating M2 Macrophages. | This study aimed to clarify the role and mechanism of tetrahedral framework nucleic acids (tFNAs) in regulating M2 macrophages to reduce intestinal injury. An intestinal injury model was established by intraperitoneal injection of lipopolysaccharides (LPS) in mice to explore the alleviating effects of tFNAs on intestin... |
39844306 | Investigation of the protective effects of dichloroacetic acid in a rat model of diabetic neuropathy. | <h4>Background</h4>Diabetic neuropathy (DN) is a heterogeneous condition characterized by complex pathophysiological changes affecting both autonomic and somatic components of the nervous system. Inflammation and oxidative stress are recognized contributors to the pathogenesis of DN. This study aims to evaluate the the... |
39844301 | Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy. | Pathological neovascularization is a hallmark of many vision-threatening diseases. However, some patients exhibit poor responses to current anti-VEGF therapies due to resistance and limited efficacy. Recent studies have highlighted the roles of noncoding RNAs in various biological processes, paving the way for RNA-base... |
39844047 | AaMYB61-like and AabHLH137 jointly regulate anthocyanin biosynthesis in Actinidia arguta. | <h4>Background</h4>Red Actinidia arguta has recently become highly popular because of its red appearance resulting from anthocyanin accumulation, and has gradually become an important breeding direction. However, regulators involved in anthocyanin biosynthesis have not been fully characterized in A. arguta.<h4>Results<... |
39844026 | Proteomics and metabolomics analyses of mechanism underlying bovine sperm cryoinjury. | <h4>Background</h4>The cryoinjury of semen during cryopreservation reduces sperm motility, constraining the application of artificial insemination (AI) in bovine reproduction. Some fertility markers, related to sperm motility before and after freezing have been identified. However, little is known about the biological ... |
39843982 | The conformational landscape of human transthyretin revealed by cryo-EM. | Transthyretin (TTR) is a natively tetrameric thyroxine transporter in blood and cerebrospinal fluid whose misfolding and aggregation causes TTR amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndamax) as a stabilizer of the native TTR fold, and this aggregation inhibitor is regula... |
39843902 | Synthesis, H<sub>2</sub>S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5'-dithioacetates. | Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H<sub>2</sub>S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable dithioacetyl group. 5'-Dithioacetate derivat... |
39843630 | Improving the odds of survival: transgenerational effects of infections. | Recent studies argue for a novel concept of the role of chromatin as a carrier of epigenetic memory through cellular and organismal generations, defining and coordinating gene activity states and physiological functions. Environmental insults, such as exposures to unhealthy diets, smoking, toxic compounds, and infectio... |
39843629 | FABP4 as a therapeutic host target controlling SARS-CoV-2 infection. | Host metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related metabolic disorders are recognized as high-risk disease modifiers for respiratory infections, including coronavirus infections, though the underlying mechanisms remain unknown. Our study highlights fatty a... |
39843610 | Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis. | The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a major challenge to global health. Targeting the main protease of the virus (Mpro), which is essential for viral replication and transcription, offers a promising approach for therapeutic intervention. In this study, advanced computational techniques such as... |
39843618 | Curcumin as a potential inhibitor of TGFβ3 computational insights for breast cancer therapy. | Previous research indicates that Transforming growth factor beta-3 (TGFβ3) expression levels correlate with breast cancer metastasis, and elevated TGFβ3 levels have been linked with poor overall survival in breast cancer patients. The study used computational methods to examine curcumin's effects on TGFβ3, a chemical w... |
39843517 | Azo dye adsorption on ZrO<sub>2</sub> and natural organic material doped ZrO<sub>2</sub>. | Natural wastes and inorganic adsorbents are used for the removal of diazo dye Congo red (CR), which causes water pollution and is a carcinogen, from wastewater. Organic waste olive pulp (ZK), inorganic ZrO<sub>2</sub> (Zr) and three different weight percent ZK/Zr (organic/inorganic) binary adsorbent systems prepared by... |
39843511 | Spectroscopic investigation of two xanthane dyes and design of a FRET based pesticide sensor. | Layer-by-Layer (LbL) technique is the simplest and inexpensive method for preparartion of nano-dimensional thin films for tailoring material behavior having wide range of applications including sensors. Here, spectroscopic behavior of two laser dyes Acriflavine (Acf) and Rhodamine B (RhB) assembled onto LbL films have ... |
39843497 | Amine functionalized magnetic resorcinol formaldehyde as a green and reusable nanocatalyst for the Knoevenagel condensation. | Herein, a novel amine-functionalized magnetic resorcinol-formaldehyde with a core-shell structure (Fe<sub>3</sub>O<sub>4</sub>@RF/Pr-NH<sub>2</sub>) is prepared through the chemical immobilization of (3-aminopropyl)trimethoxysilane over Fe<sub>3</sub>O<sub>4</sub>@RF composite. Characterization through FT-IR, EDX, PXRD... |
39843501 | Linking Research Data with Physically Preserved Research Materials in Chemistry. | Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in research data repositories in a FAIR manner. Nevertheless, in order to make chemistry a sustaina... |
39843460 | Anthropometric but not motor characteristics of young volleyball players were improved after a one-week-long intense training sports camp. | This study aimed to examine potential changes in the anthropometric and motor characteristics of volleyball players aged 17.98 ± 0.51 years after participation in a week-long sports camp. Potential changes in anthropometric characteristics were determined by bioelectrical impedance, and the players' motor characteristi... |
39843454 | Chromosome-level genome assembly and annotation of Japanese anchovy (Engraulis japonicus). | The Japanese anchovy (Engraulis japonicus), a finfish with the largest biomass of a single species in the Yellow and East China Seas, plays an important pivotal role in converting zooplanktons into high trophic fish in the food web. As a result, the fish is regard as a key species in its habiting ecosystem. However, th... |
39843440 | Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer. | Multiple receptor analysis-based DNA molecular computation has been developed to mitigate the off-target effect caused by nonspecific expression of cell membrane receptors. However, it is quite difficult to involve nanobodies into molecular computation with programmed recognition order because of the "always-on" respon... |
39843433 | Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity. | Understanding the heterogeneity of epigenetic modifications within single cells is pivotal for unraveling the nature of the complexity of gene expression and cellular function. In this study, we have developed a strategy based on multichrome encoding and "AND" Boolean logic recognition for multiplexed, spatially resolv... |
39843430 | Chemical tools to define and manipulate interferon-inducible Ubl protease USP18. | Ubiquitin-specific protease 18 (USP18) is a multifunctional cysteine protease primarily responsible for deconjugating the interferon-inducible ubiquitin-like modifier ISG15 from protein substrates. Here, we report the design and synthesis of activity-based probes (ABPs) that incorporate unnatural amino acids into the C... |
39843418 | Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis. | The multi-enzyme pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle and plays vital roles in metabolism, energy production, and cellular signaling. Although all components have been individually characterized, the intact PDHc structure remains unclear, hampering our understanding of its com... |
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