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39940133 | Shutter-Synchronized Molecular Beam Epitaxy for Wafer-Scale Homogeneous GaAs and Telecom Wavelength Quantum Emitter Growth. | Quantum dot (QD)-based single-photon emitter devices today are based on self-assembled random position nucleated QDs emitting at random wavelengths. Deterministic QD growth in position and emitter wavelength would be highly appreciated for industry-scale high-yield device manufacturing from wafers. Local droplet etchin... |
39940129 | Interfacial Charge Transfer Enhances Transient Surface Photovoltage in Hybrid Heterojunctions. | The interfacial energy level alignment in the copper phthalocyanine/SiO<sub>2</sub>/p-Si(100) heterojunction has been studied in dark conditions and under illumination. The element-sensitivity of the time-resolved X-ray photoemission provides a real-time picture of the photoexcited carrier dynamics at the interface and... |
39935895 | Photochemical corneal cross-linking: Evaluating the potential of a hand-held biopen. | The generation of organized 3D tissue constructs that combines cells and photo-crosslinkable biomaterials has been demonstrated using a variety of 3D bioprinting technologies. These technologies have inspired the application for "<i>in situ</i>" bioprinting, resulting on hand-held tools called "Biopens" that can transf... |
39926513 | Advancements in Glass Fiber Separator Technology for Lithium-Sulfur Batteries: The Role of Transport, Material Properties, and Modifications. | Lithium-sulfur batteries (LSBs) are widely regarded as a promising next-generation energy storage technology due to their exceptional theoretical capacity and energy density. However, their commercialization has been hindered by challenges such as the polysulfide shuttle effect and poor reaction kinetics, which limit e... |
39926501 | Chiral Recognition Mechanism of Amlodipine by Capillary Electrophoresis Using Carboxymethyl-β-cyclodextrin: An Experimental and Theoretical Study. | Chiral capillary electrophoresis (CCE) represents an effective technique for enantioselective separations. However, additional techniques may be necessary to determine the enantiomers migration order (EMO) and elucidate the chiral recognition mechanism. This study details the development and optimization of a CCE metho... |
39925733 | Biocompatible glycolipid derived from bhilawanol as an antibiofilm agent and a promising platform for drug delivery. | Stimuli-responsive smart materials for biomedical applications have gained significant attention because of their potential for selectivity and sensitivity in biological systems. Even though ample stimuli-responsive materials are available, the use of traditional Ayurvedic compounds in the fabrication of pharmaceutical... |
39925718 | DNA-encoded dynamic hydrogels for 3D bioprinted cartilage organoids. | Articular cartilage, composed of chondrocytes within a dynamic viscoelastic matrix, has limited self-repair capacity, posing a significant challenge for regeneration. Constructing high-fidelity cartilage organoids through three-dimensional (3D) bioprinting to replicate the structure and physiological functions of carti... |
39914967 | Adsorption performance and mechanism of a novel composite based on β-cyclodextrin polymer and chitosan: Selective and rapid removal of acid orange 7. | Continuous production of textiles results in the emission of organic dyes into the aquatic environment. The application of cyclodextrin based adsorbent allows the efficient, rapid and selective removal of organic pollutants from aqueous solutions. The present study deals with the synthesis of adsorptive composite based... |
39911731 | Structure-activity relationships in the development of single atom catalysts for sustainable organic transformations. | Single atom catalysts (SACs), which can provide the combined benefits of homogeneous and heterogeneous catalysts, are a revolutionary concept in the field of material research. The highly exposed catalytic surfaces, unsaturated sites, as well as unique structural and electronic properties of SACs have the potential to ... |
39911728 | Tetrahedral DNA framework-directed hybridization chain reaction controlled self-assembly. | Nonenzymatic isothermal nucleic acid self-assembly techniques (<i>e.g.</i>, the hybridization chain reaction, HCR) hold potential in building materials and biological sensing. However, a traditional HCR is triggered by the random diffusion and disordered conformations of ssDNA initiators, resulting in asynchronous init... |
39911371 | Engineering cardiology with miniature hearts. | Cardiac organoids offer sophisticated 3D structures that emulate key aspects of human heart development and function. This review traces the evolution of cardiac organoid technology, from early stem cell differentiation protocols to advanced bioengineering approaches. We discuss the methodologies for creating cardiac o... |
39906392 | Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation. | <h4>Background</h4>Tanshinlactone is a compound derived from the herb <i>Salvia miltiorrhiza</i>. Breast cancer is the most prevalent malignancy among women globally. While significant strides have been made in breast cancer management, these interventions are often impeded by substantial adverse effects that undermine... |
39906232 | Chrysanthemum classification method integrating deep visual features from both the front and back sides. | <h4>Introducion</h4>Chrysanthemum morifolium Ramat (hereinafter referred to as Chrysanthemum) is one of the most beloved and economically valuable Chinese herbal crops, which contains abundant medicinal ingredients and wide application prospects. Therefore, identifying the classification and origin of Chrysanthemum is ... |
39902262 | Current status of nano-embedded growth factors and stem cells delivery to bone for targeted repair and regeneration. | Bone-related diseases like osteoarthritis and osteoporosis impact millions globally, affecting quality of life. Osteoporosis considerably enhances the probability of bone fractures of the wrist, hip, and spine. Enhancement and acceleration of functional bone development can be achieved through the sustained delivery of... |
39884209 | Discriminative ion detection of Hg<sup>2+</sup> and Cu<sup>2+</sup> and selective recognition of PO<sub>4</sub><sup>3-</sup> ions: Real time monitoring in food and water samples and molecular keypad lock integration. | A series of sensors, designated S3R1-S3R4, were designed and synthesized for the detection of PO<sub>4</sub><sup>3-</sup> ions and toxic metals, specifically Hg<sup>2+</sup> and Cu<sup>2+</sup> ions. The colorimetric detection of PO<sub>4</sub><sup>3-</sup> ions using these sensors exhibited a distinct visual color tra... |
39867813 | From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment. | Nanoparticle technology has revolutionized breast cancer treatment by offering innovative solutions addressing the gaps in traditional treatment methods. This paper aimed to comprehensively explore the historical journey and advancements of nanoparticles in breast cancer treatment, highlighting their transformative imp... |
39862845 | Near-infrared-triggered release of self-accelerating cascade nanoreactor delivered by macrophages for synergistic tumor photothermal therapy/starvation therapy/chemodynamic therapy. | Macrophages have emerged as promising cellular vehicles for the delivery of therapeutic agents to tumor sites. However, the cytotoxicity of therapeutic agents toward the cellular carriers and the effective release of therapeutic agents at the tumor site remain the main challenges faced by macrophage-mediated drug deliv... |
39855020 | Selective gold extraction from e-waste leachate via sulfur-redox mechanisms using sulfhydryl-functionalized MOFs. | Urban mining of precious metals from electronic waste (e-waste) offers a dual advantage by addressing solid waste management challenges and supplying high-value metals for diverse applications. However, traditional extraction methods generally suffer from poor selectivity and limited capacity in complex acidic leachate... |
39850652 | The role of Exo70s in plant defense against pathogens and insect pests and their application for crop breeding. | Plant diseases caused by pathogens and pests lead to crop losses, posing a threat to global food security. The secretory pathway is an integral component of plant defense. The exocyst complex regulates the final step of the secretory pathway and is thus essential for secretory defense. In the last decades, several subu... |
39848528 | Memantine and amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-β interaction and effects on recognition memory in mice. | <h4>Background</h4>Adamantane derivatives, such as memantine (Mem) and amantadine (Ada), have distinct mechanisms and therapeutic applications. Ada is primarily utilized as an antiviral and anti-Parkinson drug without significant pro-cognitive effects, Mem is effective in various clinical conditions characterized by co... |
39848510 | Revealing the synergistic impacts of ZIF-8 and copper co-exposure on zebrafish behavior, tissue damage, and intestine microbial community. | The application of metal-organic frameworks (MOFs) has garnered significant attention in contemporary research. However, the impacts of MOFs on aquatic environments remain largely unclear. This study revealed that the water stability of Zeolitic Imidazolate Framework-8 (ZIF-8) is influenced by its concentration, with l... |
39848481 | Toxicity mechanism of metal-organic framework HKUST-1 and its carbonized product to Tetradesmus obliquus: Physiological and transcriptomic analysis. | Metal-organic frameworks (MOFs) are emerging materials with unique structures and properties, which have been widely used in many fields due to their various advantages. However, compared with its popular application research, the ecological safety of MOFs has rarely been reported. In this paper, a biological model, th... |
39848382 | Supramolecular cyclodextrin deep eutectic solvent-strengthened chitosan eutectogel as a novel percutaneous delivery system of resveratrol for anti-psoriasis. | Psoriasis is a chronic and incurable inflammatory skin disease usually requiring long-term disease management. Natural phytochemical resveratrol (RES) has been known for high efficiency and low toxicity, exhibiting good anti-psoriasis potential. However, its biological activity is limited by poor solubility, chemical i... |
39848376 | A hyaluronic acid modified copper-based metal-organic framework overcomes multidrug resistance via two-way redox dyshomeostasis under hypoxia. | Multidrug resistance (MDR) has become a major challenge in tumor chemotherapy, primarily associated with the overexpression of P-glycoprotein (P-gp). Inhibiting P-gp expression and function through redox dyshomeostasis has shown great potential for reversing MDR. Here, a nanoscale system of copper-based metal-organic f... |
39848370 | Elimination of Ni(II) from wastewater using metal-organic frameworks and activated algae encapsulated in chitosan/carboxymethyl cellulose hydrogel beads: Adsorption isotherm, kinetic, and optimizing via Box-Behnken design optimization. | The study investigated the enhancement of stability and efficacy in the removal of bivalent nickel ions (Ni(II)) by utilizing a cerium metal-organic framework (Ce-MOF) encapsulated within a food-grade algal matrix. This composite material is integrated into a dual-layer hydrogel containing chitosan and carboxymethyl ce... |
39845870 | Rapid access to functionalized nanographenes through a palladium-catalyzed multi-annulation sequence. | Nanographenes and polycyclic aromatic hydrocarbons exhibit many intriguing physical properties and have potential applications across a range of scientific fields, including electronics, catalysis, and biomedicine. To accelerate the development of such applications, efficient and reliable methods for accessing function... |
39844465 | Single-particle tracking reveals heterogeneous PIEZO1 diffusion. | The mechanically activated ion channel PIEZO1 is critical to numerous physiological processes, and is activated by diverse mechanical cues. The channel is gated by membrane tension and has been found to be mobile in the plasma membrane. We employed single-particle tracking (SPT) of endogenous, tdTomato-tagged PIEZO1 us... |
39839234 | Hyperbranched polyester amide/polyethersulphone mixed matrix nanofiltration membranes for contaminant rejection. | Nanofiltration (NF) separation technology is a low-pressure filtration process, which is highly efficient and environmentally friendly. As a result, it has found wide application in water treatment. This work describes the preparation of flat sheet membranes <i>via</i> the phase inversion method using blends of hyperbr... |
39839231 | Fiber ring laser biosensor based on no-core fibers for label-free DNA biomolecule measurements. | An erbium-doped fiber ring laser based on a single-mode fiber-no-core fiber-single-mode fiber (SMF-NCF-SMF) structure was constructed and experimentally demonstrated for label-free DNA hybridization measurement. The SMF-NCF-SMF structure acts as a sensing element and a filter to select the laser wavelength. The propose... |
39838784 | Dysfunction of a lepidopteran conserved gene, BmBLOC1S6, causes a translucent larval integument in the silkworm, Bombyx mori. | <h4>Background</h4>Diverse lepidopteran insects cause serious damage to plants, and their larvae possess a crucial epidermal barrier against environmental stimuli. Their ultraviolet (UV) resistance is enhanced by accumulating uric acid granules in the epidermis, suggesting that genes involved in this process may be pot... |
39838782 | Novel AIE-Active Polyarylethersulfone Polymers Incorporating Tetraphenylethene for Enhanced Fluorescence. | Aggregation-induced emission (AIE) materials have gained significant attention for their unique fluorescence enhancement in the aggregated state. However, combining rigid polymers with AIE molecules to enhance luminescent properties remains to be investigated. In this work, two novel AIE-active polyarylethersulfone (PA... |
39838767 | Piezoelectric Vitamin-Based Self-Assemblies for Energy Generation. | Structural diversity of biomolecules leads to various supramolecular organizations and asymmetric architectures of self-assemblies with significant piezoelectric response. However, the piezoelectricity of biomolecular self-assemblies has not been fully explored and the relationship between supramolecular structures and... |
39838755 | A Microwave-Strengthened Supramolecular Adhesive: from Flexible Pressure Sensitive Bonding to Strong and Muti-Reusable Hot Melt Bonding. | A microwave-strengthened supramolecular adhesive by introducing maleic acid amide bonds into the cross-linked networks of catechol-based monomers and iron oxide nanoparticles is reported. Under microwave irradiation, the supramolecular adhesive can be rapidly heated up, causing the transformation from maleic acid amide... |
39838743 | Lanthanide-Porphyrin MOF as a Multifunctional Platform for Detection and Integrated Elimination of Cr(VI) and Ciprofloxacin. | Environmental concerns are driving the development of eco-friendly and effective methods for contaminant monitoring and remediation. In this study, a lanthanide porphyrin-based MOF with dual fluorescence sensing and photocatalytic properties was synthesized and applied for the detection and combined removal of Cr(VI) a... |
39838742 | A Tribo/Piezoelectric Nanogenerator Based on Bio-MOFs for Energy Harvesting and Antibacterial Wearable Device. | New types of metal-organic framework (MOF) materials have great potential in solving the current global dilemma on energy, environment, and medical care. Herein, based on two kinds of biomolecule-MOFs (Bio-MOFs) with favorable biocompatibility and degradation-reconstruction characteristics, we have established a self-p... |
39838730 | Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications. | Polymeric nanoarchitectures are crafted from amphiphilic block copolymers through a meticulous self-assembly process. The composition of these block copolymers is finely adjustable, bestowing precise control over the characteristics and properties of the resultant polymeric assemblies. These nanoparticles have garnered... |
39838724 | Solvothermal Template-Induced Hierarchical Porosity in Covalent Organic Frameworks: A Pathway to Enhanced Diffusivity. | The rapid advancement of covalent organic frameworks (COFs) in recent years has firmly established them as a new class of molecularly precise and highly tuneable porous materials. However, compared to other porous materials, such as zeolites and metal-organic frameworks, the successful integration of hierarchical poros... |
39838717 | Confinement Induces Morphological and Topological Transitions in Multivesicles. | The study of self-assembly in confined spaces has gained significant attention among amphiphilic superstructures and colloidal design. The additional complexity introduced by interactions between contents and their containers, along with the effects of shape and lipid mixing, makes multivesicular bodies an interesting ... |
39838696 | Halogen-Bearing Peptide Liquid Crystals to Elicit Molecular Alignments for Residual Dipolar Coupling Measurement. | Residual dipolar coupling (RDC) not only contributes to the dynamic analysis of proteins but also provides a robust route for the structure determination of small organic compounds. An essential prerequisite for this methodology is the availability of alignment media. Herein, a series of novel peptide-based alignment m... |
39838623 | Observation of O<sub>2</sub> Molecules Inserting into Fe-H Bonds in a Ferrous Metal-Organic Framework. | Exploring the interactions between oxygen molecules and metal sites has been a significant topic. Most previous studies concentrated on enzyme-mimicking metal sites interacting with O<sub>2</sub> to form M-OO species, leaving the development of new types of O<sub>2</sub>-activating metal sites and novel adsorption mech... |
39838590 | Sulfated Glycosaminoglycans as Inhibitors for Chlamydia Infections: Molecular Weight and Sulfation Dependence. | Glycosaminoglycans (GAGs) play a pivotal role in pathogen attachment and entry into host cells, where the interaction with GAGs is critical for a diverse range of bacteria and viruses. This study focuses on elucidating the specific interactions between sulfated GAGs and the adhesin OmcB (Outer membrane complex protein ... |
39838448 | 4D printing: innovative solutions and technological advances in orthopedic repair and reconstruction, personalized treatment and drug delivery. | With precise control of smart materials deformation in time dimension, doctors can customize orthopedic implants. This review focuses on the advances of 4D printing technology in orthopedics, including its applications in bone repair and reconstruction, personalized treatment, and drug delivery. 4D printing enables the... |
39838282 | Genome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L. | <h4>Background</h4>WRKY transcription factors constitute one of the largest families of plant transcriptional regulators, playing pivotal roles in plant responses to biotic and abiotic stresses, as well as in hormonal signaling and secondary metabolism regulation. However, a comprehensive analysis of the WRKY family in... |
39838059 | Paying attention to the SARS-CoV-2 dialect : a deep neural network approach to predicting novel protein mutations. | Predicting novel mutations has long-lasting impacts on life science research. Traditionally, this problem is addressed through wet-lab experiments, which are often expensive and time consuming. The recent advancement in neural language models has provided stunning results in modeling and deciphering sequences. In this ... |
39837887 | Barcoded screening identifies nanocarriers for protein delivery to kidney. | Targeted protein delivery with nanocarriers holds significant potential to enhance therapeutic outcomes by precisely directing proteins to specific organs or tissues. However, the complex interactions between nanocarriers and the biological environment pose considerable challenges in designing effective targeted delive... |
39837767 | Tuning Ion Current Rectifying Nanopipettes for Sensitive Detection of Methicillin-Resistant <i>Staphylococcus aureus</i>. | Infectious diseases pose a growing challenge in healthcare, with the increasing rate of antimicrobial resistance limiting therapeutic options available for treatment. Rapid detection of infections at the earliest opportunity can significantly improve patient outcomes. In this report, ion current rectifying quartz nanop... |
39837089 | Manipulating Crystal Packing and Self-Assembly by π-Extended and Isomeric Fused Strategies in Thiophene Ring-Terminated Polycyclic Aromatic Hydrocarbons. | Two series of polycyclic aromatic hydrocarbon isomers (<b>PT-2</b> and <b>PT-3</b>, and <b>P2T-V</b> and <b>P2T-C</b>) were designed and synthesized by isomerically fusing phenanthrene with thiophene and thieno[3,2-<i>b</i>]thiophene, respectively. All of the new target molecules were confirmed by single-crystal X-ray ... |
39836969 | Insights into Calcium Phosphate Formation Induced by the Dissolution of 45S5 Bioactive Glass. | Although models have been proposed to explain the mechanisms of bioglass (BG) dissolution and subsequent calcium phosphate (CaP) mineralization, open questions remain. The processes in which phase transition occurs in aqueous solutions and their dynamics remain underexplored partly because traditional instruments/techn... |
39836702 | Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics. | Discovering new antibiotics and increasing the efficacy of existing antibiotics are priorities to address antimicrobial resistance. Antimicrobial proteins and peptides (AMPPs) are considered among the most promising antibiotic alternatives and complementary therapies. Here, we build upon previous work investigating the... |
39836657 | Nano-Zinc Sulfide Modified 3D Reconstructed Zinc Anode with Induced Deposition Effect Assists Long-Cycle Stable Aqueous Zinc Ion Battery. | Aqueous zinc ion batteries are often adversely affected by the poor stability of zinc metal anodes. Persistent water-induced side reactions and uncontrolled dendrite growth have seriously damaged the long-term service life of aqueous zinc ion batteries. In this paper, it is reported that a zinc sulfide with optimized e... |
39836648 | High-Performance Bi-Based Catalysts for CO₂ Reduction: In Situ Formation of Bi/Bi₂O₂CO₃ and Enhanced Formate Production. | The unavoidable self-reduction of Bismuth (Bi)-based catalysts to zero-valence Bi often results in detrimental adsorption of OCHO<sup>*</sup>, leading to unsatisfactory selectivity of HCOOH in the electroreduction of carbon dioxide (CO<sub>2</sub>). A novel Bi-tannin (Bi-TA) complex is developed, which undergoes in sit... |
39836636 | Ultrasensitive <sup>129</sup>Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing. | Magnetic resonance imaging (MRI) is a cornerstone technology in clinical diagnostics and in vivo research, offering unparalleled visualization capabilities. Despite significant advancements in the past century, traditional <sup>1</sup>H MRI still faces sensitivity limitations that hinder its further development. To ove... |
39836533 | Harnessing Large Language Models to Collect and Analyze Metal-Organic Framework Property Data Set. | This research focused on the efficient collection of experimental metal-organic framework (MOF) data from scientific literature to address the challenges of accessing hard-to-find data and improving the quality of information available for machine learning studies in materials science. Utilizing a chain of advanced lar... |
39836524 | Secernin-2 Stabilizes Histone Methyltransferase KMT2C to Suppress Progression and Confer Therapeutic Sensitivity to PARP Inhibition in Triple-Negative Breast Cancer. | Triple-negative breast cancer (TNBC) is a difficulty and bottleneck in the clinical treatment of breast cancer due to a lack of effective therapeutic targets. Herein, we first report that secernin 2 (SCRN2), an uncharacterized gene in human cancer, acts as a novel tumor suppressor in TNBC to inhibit cancer progression ... |
39836523 | Photosensitizable ZIF-8 BioMOF for Stimuli-Responsive Antimicrobial Phototherapy. | Resistant pathogens are increasingly posing a heightened risk to healthcare systems, leading to a growing concern due to the lack of effective antimicrobial treatments. This has prompted the adoption of antimicrobial photodynamic therapy (aPDT), which eradicates microorganisms by generating reactive oxygen species (ROS... |
39836506 | Injured Myocardium-Targeted Theranostic Nanoplatform for Multi-Dimensional Immune-Inflammation Regulation in Acute Myocardial Infarction. | Pyroptosis is a key mode of programmed cell death during the early stages following acute myocardial infarction (AMI), driving immune-inflammatory responses. Cardiac resident macrophages (CRMs) are the primary mediators of cardiac immunity, and they serve a dual role through their shaping of both myocardial injury and ... |
39836491 | Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity. | Metabolic disorders have been identified as one of the causes of drug-induced liver injury; however, the direct regulatory mechanism regarding this disorder has not yet been clarified. In this study, a single regulatory mechanism of small molecule kinase inhibitors, with crizotinib as the representative drug is elucida... |
39836245 | Lanthanide ion-based metal-organic framework as an effective tri-mode nanoprobe for alcoholic content detection. | A lanthanide ion-based metal-organic framework (Eu-TATAB nanorods) was designed and synthesized as an effective tri-mode nanoprobe for sensitive and portable detection of ethanol content in a water-ethanol mixture. The assay was based on the responsive properties of Eu-TATAB nanorods to ethanol stimulus and their adapt... |
39836155 | Structural and theoretical studies of amantadinium fenamates. | Two new crystals of amantadinium salts were obtained from fenamic and tolfenamic acid. The salt of fenamic acid is a model compound for interaction analysis, while amantadinium tolfenamate is a composition of a drug used in the treatment of symptoms of Parkinsonism and as a nonsteroidal anti-inflammatory drug. The crys... |
39835934 | 12-Hydroxy-Lauric Acid Tethered Self-Assembled Heterochiral Diphenylalanine-Based Mechanoresponsive and Proteolytically Stable Hydrogel: A Dual Player for Handling Cancer and Bacterial Challenges. | Deciphering the most promising strategy for the evolution of cancer patient management remains a multifaceted, challenging affair to date. Additionally, such approaches often lead to microbial infections as side effects, probably due to the compromised immunity of the patients undergoing such treatment. Distinctly, thi... |
39835900 | Nanoscopic acoustic vibrational dynamics of a single virus captured by ultrafast spectroscopy. | The natural vibrational frequencies of biological particles such as viruses and bacteria encode critical information about their mechanical and biological states as they interact with their local environment and undergo structural evolution. However, detecting and tracking these vibrations within a biological context a... |
39835825 | SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity. | Streptolysin O (SLO) is a virulence determinant of group A <i>Streptococcus</i> (<i>S. pyogenes</i>), the agent of streptococcal sore throat and severe invasive infections. SLO is a member of a family of bacterial pore-forming toxins known as cholesterol-dependent cytolysins, which require cell membrane cholesterol for... |
39835774 | Prussian Blue Nanozyme Featuring Enhanced Superoxide Dismutase-like Activity for Myocardial Ischemia Reperfusion Injury Treatment. | The blood flow, when restored clinically following a myocardial infarction (MI), disrupts the physiological and metabolic equilibrium of the ischemic myocardial area, resulting in secondary damage termed myocardial ischemia-reperfusion injury (MIRI). Reactive oxygen species (ROS) generation and inflammatory reactions s... |
39835701 | Pharmaceutical technological trends containing flavonoids: a patent review. | Flavonoids such as silibinin, hesperetin, and phloretin exhibit well-documented biological activities, including anti-inflammatory, cytoprotective, anticarcinogenic, and antioxidant effects. However, their clinical application remains limited due to challenges such as poor aqueous solubility, low bioavailability, and r... |
39835613 | Optimizing LiNO<sub>3</sub> Conversion through a Defective Carbon Matrix as Catalytic Current Collectors for Highly Durable and Fast-Charging Li Metal Batteries. | Lithium nitrate (LiNO<sub>3</sub>) stands as an effective electrolyte additive, mitigating the degradation of Li metal anodes by forming a Li<sub>3</sub>N-rich solid electrolyte interphase (SEI). However, its conversion kinetics are impeded by energy-consuming eight-electron transfer reactions. Herein, an isoreticular ... |
39835583 | Molecular Phosphide Complexes of Zirconium. | Molecular Zr<sup>IV</sup> phosphides are extremely rare, with no examples containing a one-coordinated and terminal triple-bonded phosphorus atom. We report here an isolable and relatively stable Zr phosphide complex, [(PN)<sub>2</sub>Zr≡P{μ<sub>2</sub>-Na(OEt<sub>2</sub>)}]<sub>2</sub> (<b>4</b>), stemming from a cycl... |
39835457 | Methane Bubbled Through Seawater Can be Converted to Methanol With High Efficiency. | Partial oxidation of methane (POM) is achieved by forming air-methane microbubbles in saltwater to which an alternating electric field is applied using a copper oxide foam electrode. The solubility of methane is increased by putting it in contact with water containing dissolved KCl or NaCl (3%). Being fully dispersed a... |
39834323 | Extracellular Matrix-Inspired Dendrimer Nanogels Encapsulating Cyclophosphamide for Systemic Sclerosis Treatment. | Cyclophosphamide has a certain therapeutic effect on treating systemic sclerosis (SSc), while difficulties exist in controlling severe systematic side effects and enhancing targeting capacity. Here, inspired from the natural extracellular matrix composition, we propose a cyclophosphamide-encapsulated nanogel based on d... |
39833784 | Advances in nucleic acid-based cancer vaccines. | Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to the COVID-19 pandemic. The widespread administration of mRNA vaccines against COVID-19 to billions globally marks a significant milestone. Furthermore, the approval of an mRNA vaccine for... |
39833559 | Activation and evasion of inflammasomes during viral and microbial infection. | The inflammasome is a cytoplasmic multiprotein complex that induces the maturation of the proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) or pyroptosis by activating caspases, which play critical roles in regulating inflammation, cell death, and various cellular processes. Multiple studies h... |
39833366 | Computational insight into the formation of cation-π/cation-lone pair complexes between 3d-metal (II) ions and furan. | <h4>Context</h4>Cation-π and cation-lone pair interactions between 3d-metal (II) ions [Fe(II), Co(II), Ni(II) and Cu(II)] and furan are explored in the formation of 1:1 and 1:2 type complexes. Both cation-π (IE<sub>gas</sub> = -192.27 to -312.65 kcal mol<sup>-1</sup>) and cation-lone pair (IE<sub>gas</sub> = -163.13 to... |
39833169 | Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation. | Apoptotic protease activating factor 1 (Apaf-1) was traditionally defined as a scaffold protein in mammalian cells for assembling a caspase activation platform known as the 'apoptosome' after its binding to cytochrome c. Although Apaf-1 structurally resembles animal NOD-like receptor (NLR) and plant resistance (R) prot... |
39829237 | Recent advances on brain drug delivery via nanoparticles: alternative future materials for neuroscience applications; a review. | Essentially, the blood-brain barrier (BBB) serves as a line of demarcation between neural tissues and the bloodstream. A unique and protective characteristic of the blood-brain barrier is its ability to maintain cerebral homeostasis by regulating the flux of molecules and ions. The inability to uphold proper functionin... |
39810598 | Retrieving the Stability and Practical Performance of Activation-Unstable Mesoporous Zr(IV)-MOF for Highly Efficient Self-Calibrating Acidity Sensing. | The practical applications of activation-unstable mesoporous metal-organic frameworks (MOFs) are often constrained by their structural instability. However, enhancing their stability could unlock valuable functionalities. Herein, we stabilized the otherwise unstable, post-activated structure of a novel mesoporous Zr(IV... |
39809422 | Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights. | Selenium deficiency associated with a high risk of many diseases remains a global challenge. Owing to the narrow margin between "nutrition-toxicity" doses of selenium, it is imperative to achieve accurate selenium supplement. Nano‑selenium (SeNPs) is a novel form of selenium supplement with low toxicity, but it could b... |
39804698 | Control of Interlocking Mode in Pd<sub>4</sub>L<sub>8</sub> Cage Catenanes. | Precise control over the catenation process in interlocked supramolecular systems remains a significant challenge. Here, we report a system in which a lantern-shaped Pd<sub>2</sub>L<sub>4</sub> cage can dimerize to form two distinct Pd<sub>4</sub>L<sub>8</sub> catenanes with different interlocking degree: a previously ... |
39804699 | Porous Organic Polymers Incorporating Shape-Persistent Cyclobenzoin Macrocycles for Organic Solvent Separation. | The recovery and separation of organic solvents is highly important for the chemical industry and environmental protection. In this context, porous organic polymers (POPs) have significant potential owing to the possibility of integrating shape-persistent macrocyclic units with high guest selectivity. Here, we report t... |
39803865 | Chiral Nanofibers of Camptothecin Trigger Pyroptosis for Enhanced Immunotherapy. | Camptothecin (CPT), a chemotherapeutic agent, demonstrates significant potential in cancer therapy. However, as a drug, CPT molecule suffers from poor water solubility, limited bioavailability, and insufficient immune response. Herein, we construct CPT nanofibers (CNF) with a right-handed chiral property via supramolec... |
39800998 | Regularly Arranged Heterogeneous Pores in Gas Separation Membranes Constructed by Cocrystallization of Porous Organic Molecules. | Integrating two or more materials to construct membranes with heterogeneous pore structures is an effective strategy for enhancing separation performance. Regularly arranging these heterogeneous pores can significantly optimize the combined effect of the introduced components. Porous Organic Cages (POCs), an emerging s... |
39800988 | A Gate-Opening Control Strategy via Nitrate-Chloride Anion Exchange for Enhanced Hydrogen Isotope Separation in Metal-Organic Frameworks. | Efficient separation of hydrogen isotopes, especially deuterium (D<sub>2</sub>), is pivotal for advancing industries such as nuclear fusion, semiconductor processing, and metabolic imaging. Current technologies, including cryogenic distillation and Girdler sulfide processes, suffer from significant limitations in selec... |
39800660 | Boosting One- and Two-Photon Excited Fluorescence of Interpenetrated Tetraphenylethene-Based Metal-Organic Frameworks (TPE-MOFs) by Linker Installation. | Immobilizing organic chromophores within the rigid framework of metal-organic frameworks (MOFs) augments fluorescence by effectively curtailing molecular motions. Yet, the substantial interspaces and free volumes inherent to MOFs can undermine photoluminescence efficiency, as they partially constrain intramolecular dyn... |
39791967 | Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content. | Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unim... |
39791445 | Self-Assembly of Amorphous 2D Polymer Nanodiscs with Tuneable Size, pH-Responsive Degradation and Controlled Drug Release. | Amphiphilic bottlebrush block copolymers (BBCs) with tadpole-like, coil-rod architecture can be used to self-assemble into functional polymer nanodiscs directly in water. The hydrophobic segments of the BBC were tuned via the ratio of ethoxy-ethyl glycidyl ether (EE) to tetrahydropyranyl glycidyl ether (TP) within the ... |
39785152 | Vesicle-Encapsulated Chemosensing Ensembles Allow Monitoring of Transmembrane Uptake Coupled with Enzymatic Reactions. | Compartmentalized models with coupled catalytic networks are considered as "protocells" in the context of research related to the origin of life. To model the kinetics of a simple cellular uptake-metabolism process, we use a compartmentalized protocell system that combines liposome-encapsulated intravesicular reporter ... |
39777831 | In Situ Growth of Metal-Organic Layer on Polyoxometalate-etching Cu<sub>2</sub>O to Boost CO<sub>2</sub> Reduction with High Stability. | Low-cost Cu<sub>2</sub>O with a suitable band gap holds great potential for solar utilization. However severe photocorrosion and weak CO<sub>2</sub> capture capability have significantly hindered their application in artificial photosynthesis. Herein, polyoxometalate (POM)-etching and in situ growth of metal-organic fr... |
39752587 | Conformationally Restricted Macrocycles as Improved FKBP51 Inhibitors Enabled by Systematic Linker Derivatization. | Macrocycles are increasingly considered as promising modalities to target challenging intracellular proteins. However, strategies for transitioning from active linear starting points to improved macrocycles are still underdeveloped. Here we explored the derivatization of linkers as an approach for macrocycle optimizati... |
39745319 | Construction of stable Cu<sup>+</sup>/Cu<sup>0</sup> sites at the fullerene/Cu(OH)F interface to boost the electroreduction of CO<sub>2</sub> to C<sub>2+</sub> products. | Herein, the reduction of the Cu oxidation state during the CO<sub>2</sub> electro-reduction reaction (CO<sub>2</sub>RR) is effectively inhibited by depositing C<sub>60</sub> supramolecular clusters onto the Cu(OH)F surface. By utilizing the unique electronic buffering capacity of C<sub>60</sub>, a significant number of... |
39718004 | Unveiling the Photoluminescence Mechanism of Carbonized Polymer Dots: Evolution and Synergistic Photoluminescence of Multiple Molecular Fluorophores. | Carbonized polymer dots (CPDs) are a class of exceptional fluorescent materials with diverse applications. However, their photoluminescence (PL) mechanism remained enigmatic and controversial, hindering further development and application. While molecular fluorophores explain primary fluorescence in some CPDs, the over... |
39714426 | A Dynamic Metal-Organic Radical Emission System. | Developing new organic radical emission systems and regulating their luminescence properties presents a significant challenge. Herein, we build dynamic and multi-emission band radical luminescence systems by co-assembling inorganic metal salts with carbonyl compounds in ionic liquids. After the assembling, dual-band, a... |
39665278 | UTSA-16(Zn) for SO<sub>2</sub> detection: elucidating the fluorescence mechanism. | In this study, the potential of the metal-organic framework UTSA-16(Zn) as a fluorescence detector for SO<sub>2</sub> is explored. The material was synthesized and characterized by powder X-ray diffraction (PXRD), infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), and its fluorescence behavior was analy... |
39660581 | Recent advancements in metal-organic framework-based aptasensors. | Metal-organic frameworks (MOFs), as a class of crystalline organic-inorganic hybrid materials, have demonstrated excellent performance in many fields, resulting in attracting more and more attention. Recently, MOFs have been widely used as functional materials to immobilize aptamers <i>via</i> various interaction force... |
39660446 | Ni(II)-Dithiocarbamate and -diphosphine coordination complexes as pre-catalysts for electrochemical OER activity. | Electrochemical water oxidation holds immense potential for sustainable energy generation, splitting water into clean-burning hydrogen and life-giving oxygen. However, a key roadblock lies in the sluggish nature of the oxygen evolution reaction (OER). Finding stable, cost-effective, and environmentally friendly catalys... |
39652364 | Photoluminescent chain-of-dimer anion in a novel hybrid halometallate (C<sub>5</sub>H<sub>14</sub>N<sub>2</sub>)<sub>3</sub>{Sb<sub>2</sub>Br<sub>9</sub>}<sub>2</sub>: atypical behavior in one-dimensional anionic systems. | In pursuit of identifying less toxic hybrid compounds suitable for optoelectronic applications, we synthesized a novel homopiperazinium bromoantimonate(III), (C<sub>5</sub>H<sub>14</sub>N<sub>2</sub>)<sub>3</sub>{Sb<sub>2</sub>Br<sub>9</sub>}<sub>2</sub>. It readily crystallized from an aqueous hydrobromic acid solutio... |
39629740 | Selective lithium halide ion-pair sensing by a dynamic metalloporphyrin [2]rotaxane. | A dynamic zinc(II) metalloporphyrin axle-containing [2]rotaxane with a heteroditopic macrocycle component is shown to selectively recognise and optically sense lithium halide (LiX) ion-pair species. <sup>1</sup>H NMR and UV-visible absorption experiments demonstrate a strong macrocycle pyridyl⋯Zn(II) metalloporphyrin a... |
39625410 | Error compensated MOF-based ReRAM array for encrypted logical operations. | Metal-organic frameworks (MOFs) form a unique platform for operation with data using ReRAM technology. Here we report on a large-scale fabrication of a MOF-based ReRAM array with 6 × 6 cells, demonstrating 50% variation in their electronic parameters. Despite this inhomogeneity, such a "non-ideal" ReRAM array is used f... |
39625226 | A copper(II)-based metal-organic framework: electrochemical sensing of Cd(II) and Pb(II) and adsorption of organic dyes. | A new inorganic-organic hybrid complex, namely [Cu<sub>3</sub>L<sub>2</sub>(DMF)<sub>2</sub>]·H<sub>2</sub>O (Cu-L), has been synthesized using a sulfur-rich ligand, 3,3',3''-(1,3,5-triazine-2,4,6-triyltrisulfanediyl)tripropanoic acid (H<sub>3</sub>L) and metal cations under hydrothermal conditions. The metal atoms are... |
39523808 | A ratiometric luminescence thermometer based on lanthanide encapsulated complexes. | Lanthanide-containing complexes have been widely developed as ratiometric luminescence thermometers, which are non-invasive, contactless and accurate. The synthesis of these Ln complexes generally requires high temperatures, multiple steps and other harsh conditions. Moreover, bimetallic lanthanide complexes, which hav... |
41383673 | Performance of major liver resection for gallbladder cancer-a western retrospective single center cohort study. | <h4>Background</h4>Gallbladder cancer (GBCa) is a rare disease in western countries and surgery remains the state of art, given the tumor is technically resectable. However, data for major liver resection in patients with advanced GBCa is scarce. Objective of this study was to analyze survival outcome measures of patie... |
40657007 | Brain-derived neurotrophic factor gene polymorphism rs6265 and elite athlete status in four independent populations. | This research aimed to investigate the association of the BDNF rs6265 polymorphism with elite athletic status in four different populations: Japanese and European Caucasian cohorts from Italy, Poland, and Lithuania. A total of 1,644 professional athletes (868 Japanese, 177 Italian, 369 Polish, 230 Lithuanian) and 1,948... |
40290277 | Metasurface-enhanced biomedical spectroscopy. | Enhancing the sensitivity of biomedical spectroscopy is crucial for advancing medical research and diagnostics. Metasurfaces have emerged as powerful platforms for enhancing the sensitivity of various biomedical spectral detection technologies. This capability arises from their unparalleled ability to improve interacti... |
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