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39843406 | Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection. | <h4>Background</h4>Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are complex and challenging due to their intricate pathophysiology and limited treatment options.<h4>Methods</h4>This review systematically sourced articles related to neurodegenerative dis... |
39843400 | Direct Observation of Structural Phase Transformations during Phosphorene Formation on Cu(111). | Blue phosphorene, a two-dimensional, hexagonal-structured, semiconducting phosphorus, has gained attention as it is considered easier to synthesize on metal surfaces than its allotrope, black phosphorene. Recent studies report different structures of phosphorene, for example, on Cu(111), but the underlying mechanisms o... |
39841998 | Bipolar Solid-Solution Hosts for Efficient Crystalline Organic Light-Emitting Diodes. | Crystalline organic semiconductors, recognized for their highly ordered structures and high carrier mobility, have emerged as a focal point in the field of high-performance optoelectronic devices. Nevertheless, the intrinsic unipolar properties, characterized by imbalanced hole and electron transport capabilities, have... |
39841921 | Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells. | A key challenge in modern chemistry research is to mimic life-like functions using simple molecular networks and the integration of such networks into the first functional artificial cell. Central to this endeavor is the development of signaling elements that can regulate the cell function in time and space by producin... |
39841887 | Defect Structures in Colloidal Crystals and Their Effect on Grating Diffraction Structural Color. | Colloidal crystals of micrometer-sized colloids create prismatic structural colors through the grating diffraction of visible light. Here, we develop design rules to engineer such structural color by specifically accounting for the effect of crystal defects. The local quality and grain size of the colloidal structure a... |
39841883 | Lanthanide Metal-Organic Framework Flowers for Proteome Profiling and Biomarker Identification in Ultratrace Biofluid Samples. | Identifying effective biomarkers has long been a persistent need for early diagnosis and targeted therapy of disease. While mass spectrometry-based label-free proteomics with trace cell has been demonstrated, deep proteomics with ultratrace human biofluid remains challenging due to low protein concentration, extremely ... |
39841885 | Hydrogen-Bond-Regulated Tb<sup>3+</sup>-Centered Emission in a Zn<sup>II</sup>-Tb<sup>III</sup> Heterometallic Compound for Water Sensing in Ethanol and Gasoline. | Luminescent lanthanide compounds stand out for their distinctive characteristics including narrow emission bands, substantial Stokes shifts, high quantum yields, and unique luminescent colors. However, Ln<sup>3+</sup> is highly susceptible to vibrational quenching from X-H (X = O/N) high-energy oscillators in the embed... |
39841881 | Attention-Based Interpretable Multiscale Graph Neural Network for MOFs. | Metal-organic frameworks (MOFs) hold great potential in gas separation and storage. Graph neural networks (GNNs) have proven effective in exploring structure-property relationships and discovering new MOF structures. Unlike molecular graphs, crystal graphs must consider the periodicity and patterns. MOFs' specific feat... |
39841852 | Advancing efficiency in deep-blue OLEDs: Exploring a machine learning-driven multiresonance TADF molecular design. | The pursuit of boron-based organic compounds with multiresonance (MR)-induced thermally activated delayed fluorescence (TADF) is propelled by their potential as narrowband blue emitters for wide-gamut displays. Although boron-doped polycyclic aromatic hydrocarbons in MR compounds share common structural features, their... |
39841856 | Beyond <i>In Vivo</i>, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein. | Throughout history, we have looked to nature to discover and copy pharmaceutical solutions to prevent and heal diseases. Due to the advances in metabolic engineering and the production of pharmaceutical proteins in different host cells, we have moved from mimicking nature to the delicate engineering of cells and protei... |
39841849 | Dynamic molecular architecture of the synaptonemal complex. | During meiosis, pairing between homologous chromosomes is stabilized by the assembly of the synaptonemal complex (SC). The SC ensures the formation of crossovers between homologous chromosomes and regulates their distribution. However, how the SC regulates crossover formation remains elusive. We isolated an unusual mut... |
39841841 | Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs. | Bacterial type IV secretion systems (T4SSs) are widespread nanomachines specialized in the transport across the cell envelope of various types of molecules including mobile genetic elements during conjugation. Despite their prevalence in Gram-positive bacteria, including relevant pathogens, their assembly and functioni... |
39841833 | Metal-organic cages improving microporosity in polymeric membrane for superior CO<sub>2</sub> capture. | Mixed matrix membranes, with well-designed pore structure inside the polymeric matrix via the incorporation of inorganic components, offer a promising solution for addressing CO<sub>2</sub> emissions. Here, we synthesized a series of novel metal organic cages (MOCs) with aperture pore size precisely positioned between ... |
39841801 | Metabolic Reprogramming of Neural Stem Cells by Chiral Nanofiber for Spinal Cord Injury. | Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal neural circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. This report discusses the biomimetic dextral hydrogel (DH) with right-handed nanofibers that specifically ... |
39841785 | Engineered Extracellular Vesicles from Antler Blastema Progenitor Cells: A Therapeutic Choice for Spinal Cord Injury. | Deer antler blastema progenitor cells (ABPCs) are promising for regenerative medicine due to their role in annual antler regeneration, the only case of complete organ regeneration in mammals. ABPC-derived signals show great potential for promoting regeneration in tissues with limited natural regenerative ability. Our f... |
39841716 | Development of a novel multi-epitope mRNA vaccine candidate to combat SFTSV pandemic. | Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) is a novel identified pathogen, despite two decades of research on SFTSV, the potential widespread threats pose a significant challenge for researchers in developing new treatment and prevention methods. In this present, we have developed a multi-epitope mRNA va... |
39841546 | Disassembly of Virus-Like Particles and the Stabilizing Role of the Nucleic Acid Cargo. | In many simple viruses and virus-like particles, the protein capsid self-assembles around a nucleic-acid genome. Although the assembly process has been studied in detail, relatively little is known about how the capsid disassembles, a potentially important step for infection (in viruses) or cargo delivery (in virus-lik... |
39841523 | Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study. | <h4>Background</h4>Recent research has revealed the potential value of machine learning (ML) models in improving prognostic prediction for patients with trauma. ML can enhance predictions and identify which factors contribute the most to posttraumatic mortality. However, no studies have explored the risk factors, compl... |
39841395 | <sup>15</sup>N-detected TROSY for <sup>1</sup>H-<sup>15</sup>N heteronuclear correlation to study intrinsically disordered proteins: strategies to increase spectral quality. | Intrinsically disordered proteins and protein regions are central to many biological processes but difficult to characterize at atomic resolution. Nuclear magnetic resonance is particularly well-suited for providing structural and dynamical information on intrinsically disordered proteins, but existing NMR methodologie... |
39841331 | Correlation of precisely fabricated geometric characteristics of DNA-origami nanostructures with their cellular entry in human lens epithelial cells. | Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g., mitochondrion and nucleus), is a key step in engineering cells for cell- and gene- based t... |
39841330 | Convergence of nanotechnology and artificial intelligence in the fight against liver cancer: a comprehensive review. | Liver cancer is one of the most challenging malignancies, often associated with poor prognosis and limited treatment options. Recent advancements in nanotechnology and artificial intelligence (AI) have opened new frontiers in the fight against this disease. Nanotechnology enables precise, targeted drug delivery, enhanc... |
39841318 | Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study. | A series of flavonoid derivatives containing piperazine sulfonate were designed and synthesized. The results of antiviral experiments in vivo showed that some target compounds had good inhibitory effect on tobacco mosaic virus (TMV). The EC<sub>50</sub> values of S15 and S19 curative activity were 174.5 and 110.4 μg/mL... |
39841280 | Computational investigation of the perylene-TCNQ complex: effects of chalcogen and fluorine substitutions. | <h4>Context</h4>Donor-acceptor (D-A) complexes, formed between two or more molecules held together by intermolecular forces, show interesting tunable properties and found applications in diverse fields, including semiconductors, catalysis, and sensors. In this study, we investigated the D-A complexes formed between per... |
39841169 | Effect of Lipidation on the Structure, Oligomerization, and Aggregation of Glucagon-like Peptide 1. | Lipidated analogues of glucagon-like peptide 1 (GLP-1) have gained enormous attention as long-acting peptide therapeutics for type 2 diabetes and also antiobesity treatment. Commercially available therapeutic lipidated GLP-1 analogues, semaglutide and liraglutide, have the great advantage of prolonged half-lives <i>in ... |
39841135 | Macrocyclization as a Strategy for Kinetic Solubility Improvement: A Comparative Analysis of Matched Molecular Pairs. | In recent years, rationally designed macrocycles have emerged as promising therapeutic modalities for challenging drug targets. Macrocycles can improve affinity, selectivity, and pharmacokinetic (PK) parameters, possibly via providing semirigid, preorganized scaffolds. Nevertheless, how macrocyclization affects PK-rele... |
39841124 | Collagen Alpha 1(XI) Amino-Terminal Domain Modulates Type I Collagen Fibril Assembly. | The amino-terminal domain of collagen α1(XI) plays a key role in controlling fibrillogenesis. However, the specific mechanisms through which various isoforms of collagen α1(XI) regulate this process are not fully understood. We measured the kinetics of collagen type I self-assembly in the presence of specific collagen ... |
39841046 | MASP1 modulation as a novel therapeutic target in severe pediatric pertussis: insights from a multi-omics approach. | Pertussis, a severe infectious disease in children, has become increasingly prominent in recent years. This study aims to investigate the role of the MASP1 protein in severe pertussis in children through multi-omics analysis, providing a theoretical basis for the development of novel therapeutic strategies. The study r... |
39841010 | Deuterated Nanopolymers for Renal and Lymphatic Imaging via Quantitative Deuterium MRI. | Deuterium (<sup>2</sup>H) MRI is an emerging tool for noninvasive imaging. We explore the integration of <sup>2</sup>H MRI with deuterated multifunctional nanopolymers for deuterated particle imaging (DPI). To this end, amine-terminated G5-polyamidoamine (PAMAM) dendrimers were labeled with deuterated acetyl surface gr... |
39840997 | Serotonergic Mechanisms in Proteinoid-Based Protocells. | This study examines the effects of incorporating serotonin (5-HT) into proteinoid microspheres. It looks at the microspheres' structure and electrochemical properties. Proteinoid-serotonin assemblies have better symmetry and membrane organization than pristine proteinoids. Cyclic voltammetry shows a big boost in electr... |
39840987 | A novel neutralizing antibody recognizing a conserved conformational epitope in PDCoV S1 protein and its therapeutic efficacy in piglets. | Porcine deltacoronavirus (PDCoV) is an enteric pathogen that burdens the global pig industry and is a public health concern. The development of effective antiviral therapies is necessary for the prevention and control of PDCoV, yet to date, there are few studies on the therapeutic potential of PDCoV-neutralizing antibo... |
39840971 | The cytoplasmic tail of IBV spike mediates intracellular retention via interaction with COPI-coated vesicles in retrograde trafficking. | Coronaviruses are characterized by their progeny assembly and budding in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). Our previous studies demonstrated that truncation of 9 amino acids in the cytoplasmic tail (CT) of the infectious bronchitis virus (IBV) spike (S) protein impairs its localization t... |
39840927 | Dual Targeting Biomimetic Carrier-Free Nanosystems for Photo-Chemotherapy of Rheumatoid Arthritis via Macrophage Apoptosis and Re-Polarization. | Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that often results in irreversible joint erosion and disability. Methotrexate (MTX) is the first-line drug against RA, but the significant side effects of long-term administration limit its use. Therefore, new therapeutic strategies are needed fo... |
39840912 | What Two-Dimensional Electronic Spectroscopy Can Tell Us about Energy Transfer in Dendrimers: Ab Initio Simulations. | Two-dimensional (2D) electronic spectra of the phenylene ethynylene dendrimer with 2-ring and 3-ring branches were evaluated by combining the on-the-fly trajectory surface hopping nonadiabatic dynamics and the doorway-window simulation protocol. The ground state bleach (GSB), stimulated emission (SE), and excited-state... |
39840721 | Phonon Involved Photoluminescence of Mn<sup>2+</sup> Ions Doped CsPbCl<sub>3</sub> Micro-Size Perovskite Assembled Crystals. | Mn<sup>2+</sup> ions doped CsPbCl<sub>3</sub> perovskite nanocrystals (NCs) exhibit superiority of spin-associated optical and electrical properties. However, precisely controlling the doping concentration, doping location, and the mono-distribution of Mn<sup>2+</sup> ions in the large-micro-size CsPbCl<sub>3</sub> per... |
39840619 | Extreme Tolerance of Nanoparticle-Protein Corona to Ultra-High Abundance Proteins Enhances the Depth of Serum Proteomics. | The serum nanoparticle-protein corona (NPC) provides specific disease information, thus opening a new avenue for high-throughput in-depth proteomics to facilitate biomarker discovery. Yet, little is known about the interactions between NPs and proteins, and its role in enhanced depth of serum proteomics. Herein, a seri... |
39840615 | Significant Efficiency Enhancements in Non-Y Series Acceptors by the Addition of Outer Side Chains. | Most current highly efficient organic solar cells utilize small molecules like Y6 and its derivatives as electron acceptors in the photoactive layer. In this work, a small molecule acceptor, SC8-IT4F, is developed through outer side chain engineering on the terminal thiophene of a conjugated 6,12-dihydro-dithienoindeno... |
39840608 | Masquelet Inspired in Vivo Engineered Extracellular Matrix as Functional Periosteum for Bone Defect Repair and Reconstruction. | The Masquelet technique that combines a foreign body reaction (FBR)-induced vascularized tissue membrane with staged bone grafting for reconstruction of segmental bone defect has gained wide attention in Orthopedic surgery. The success of Masquelet hinges on its ability to promote formation of a "periosteum-like" FBR-i... |
39840602 | Supramolecular Organic Nanofiller: A New Reinforcement Strategy for Dynamic Covalent Polymer Networks Toward Upcycling of Carbon Fiber Composites. | Dynamic covalent polymer networks (DCPN) provide an important solution to the challenging recyclability of thermoset elastomers. However, dynamic bonds exhibit relatively weak bond energies, considerably decreasing the mechanical properties of DCPN. Herein, a novel reinforcement strategy for DCPN involving the in situ ... |
39840576 | Hinged Carboxylate in the Artificial Distal Pocket of an Iron Porphyrin Enhances CO<sub>2</sub> Electroreduction at Low Overpotential. | To efficiently capture, activate, and transform small molecules, metalloenzymes have evolved to integrate a well-organized pocket around the active metal center. Within this cavity, second coordination sphere functionalities are precisely positioned to optimize the rate, selectivity, and energy cost of catalytic reacti... |
39840556 | Combining Hard Shell with Soft Core to Enhance Enzyme Activity and Resist External Disturbances. | Immobilizing enzymes onto solid supports having enhanced catalytic activity and resistance to harsh external conditions is considered as a promising and critical method of broadening enzymatic applications in biosensing, biocatalysis, and biomedical devices; however, it is considerably hampered by limited strategies. H... |
39840545 | ZnFe Layered Double Hydroxide Nanosheets Loaded with Cu Single-Atom Nanozymes with Multi-Enzyme-Like Catalytic Activities as an Effective Treatment for Bacterial Keratitis. | Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials in corneal wound healing, currently available nanozymes lack sufficient catalytic activity and the ability to penetrate bacterial biofilms, limiting thei... |
39840543 | Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis. | Osteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting ferroptosis regulation presents a promising therapeutic strategy for OA; however, current research primarily focuses on single targets associated with ferroptosis. In thi... |
39840532 | Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer. | In triple-negative breast cancer (TNBC), pro-tumoral macrophages promote metastasis and suppress the immune response. To target these cells, a previously identified CD206 (mannose receptor)-binding peptide, mUNO was engineered to enhance its affinity and proteolytic stability. The new rationally designed peptide, MACTI... |
39840530 | Efficient Carbon-Based Optoelectronic Synapses for Dynamic Visual Recognition. | The human visual nervous system excels at recognizing and processing external stimuli, essential for various physiological functions. Biomimetic visual systems leverage biological synapse properties to improve memory encoding and perception. Optoelectronic devices mimicking these synapses can enhance wearable electroni... |
39840495 | In Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self-Healing Multifunctional Waterborne Polyurethane. | Nowadays, much attention is paid to the development of high-performance and multifunctional materials, but it is still a great challenge to obtain polymer materials with high mechanical properties, high self-healing properties, and multifunctionality in one. Herein, an innovative strategy is proposed to obtain a satisf... |
39840494 | Viral Membrane-Targeting Amphipathic Helical Peptide-Based Fluorogenic Probes for the Analysis of Infectious Titers of Enveloped Viruses. | Enveloped viruses have caused the majority of epidemics and pandemics over the past decade. Direct sensing of virus particles (virions) holds great potential for the functional analysis of enveloped viruses. Here, we explore a series of viral membrane-targeting amphipathic helical (AH) peptide-based molecular probes fo... |
39840461 | Gaseous Synergistic Self-Assembly and Arraying to Develop Bio-Organic Photocapacitors for Neural Photostimulation. | Bioinspired supramolecular architectonics is attracting increasing interest due to their flexible organization and multifunctionality. However, state-of-the-art bioinspired architectonics generally take place in solvent-based circumstance, thus leading to achieving precise control over the self-assembly remains challen... |
39838964 | <i>Talaromyces purpureogenus</i> CEF642<sup>N</sup> as a Promising Biocontrol Agent for Cotton Disease Control. | Endophytic fungi live in healthy plant tissues and organs and are a major source of natural bioactive compounds. In this study, we found that an endophytic fungus, <i>Talaromyces purpureogenus</i> CEF642<sup>N</sup>, isolated from the healthy cotton roots, suppressed <i>Verticillium dahliae</i> by up to 53% after 15 da... |
39838860 | Stereocontrolled Synthesis of the Portimine Skeleton via Organocatalyst-Mediated Asymmetric Stannylation and Stereoretentive C(<i>sp</i><sup>3</sup>)-C(<i>sp</i><sup>2</sup>) Stille Coupling. | Our efforts toward the synthesis of the marine natural product portimine are described. The key to the synthesis of the skeleton is a stereoretentive copper-catalyzed C(<i>sp</i><sup>3</sup>)-C(<i>sp</i><sup>2</sup>) Stille-type cross-coupling that enables the convergent assembly of functionalized fragments. The core s... |
39838126 | Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations. | TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and is overexpressed in different types of cancers. Therefore, this study aims to disover potential TMPRSS4 inhibit... |
39837871 | Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography. | Electron ptychography, recognized as an ideal technique for low-dose imaging, consistently achieves deep sub-angstrom resolution at electron doses of several thousand electrons per square angstrom (e<sup>-</sup>/Å<sup>2</sup>) or higher. Despite its proven efficacy, the application of electron ptychography at even lowe... |
39817597 | Kinetic Separation of Butane Isomers Using a Formate Metal-Organic Framework. | n-butane (n-C<sub>4</sub>H<sub>10</sub>) and isobutane (i-C<sub>4</sub>H<sub>10</sub>) are important raw materials in chemical industry. The separation of the two hydrocarbon isomers via distillation is challenging and energy-consuming. Herein we report the adsorption behavior of a microporous cobalt formate framework ... |
39814606 | Fluorescent Macrocyclic Arenes: Synthesis and Applications. | Fluorescent macrocyclic arenes have attracted increasing interest in macrocyclic and supramolecular chemistry due to their exceptional photophysical properties and versatile applications. Classical macrocyclic arenes modified with fluorescent groups at the upper or bottom rims have long provided valuable platforms acro... |
39808487 | Kinetic Control of Self-Assembly Pathway in Dual Dynamic Covalent Polymeric Systems. | Kinetically controlled self-assembly is garnering increasing interest in the field of supramolecular polymers and materials, yet examples involving dynamic covalent exchange remain relatively unexplored. Here we report an unexpected dynamic covalent polymeric system whose aqueous self-assembly pathway is strongly influ... |
39789987 | Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network. | Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and supramolecular interactions. In this communication, we expand the capabilities of covalent poly(ethylene glycol) (PEG) n... |
39789923 | Thiol-terminated <i>N</i>-halamine ligands to photothermal gold nanorods for synergistically combating antibiotic-resistant bacteria. | Bio-friendly antibacterial <i>N</i>-halamine polymers were used to modify gold nanorods (GNR@pAMPS-Cl), which showed excellent antimicrobial activity against antibiotic-resistant bacteria and accelerated the healing of MRSA-infected wounds. This work provides a new strategy for the preparation of nanoscale antibacteria... |
39777999 | Anion-Responsive π-Conjugated Macrocycles That Form Ordered Structures. | In this study, anion-responsive π-conjugated macrocycles were synthesized to demonstrate anion-binding and ion-pairing properties along with the ordered structures. Ion-pairing charge-by-charge assembly of a [1+2]-type complex of a macrocycle as a pseudo π-electronic anion and a countercation was revealed by single-cry... |
39749536 | Spectroscopic investigation of proton bonding at sub-kelvin temperatures. | The proton bond is a pivotal chemical motif in many areas of science and technology. Its quantum chemical description is remarkably challenged by nuclear and charge delocalization effects and the fluxional perturbation that it induces on molecular substrates. This work seeks insights into proton bonding at sub-kelvin t... |
39745252 | A theoretical comparison of different third component content in ternary organic solar cells. | Ternary solar cells have been rapidly developed in the realm of organic solar cells (OSCs). The incorporation of a third component into a cell results in a complicated active layer morphology, and the relation of this morphology to power conversion efficiency remains elusive. In this work, two ternary active layers, B1... |
39745104 | Synthesis of 2D NiCo-MOF/GO/CNTs flexible films for high-performance supercapacitors. | Flexible two-dimensional nickel-cobalt metal-organic frameworks/graphene oxide/carbon nanotubes (2D NiCo-MOF/GO/CNTs) hybrid films have been designed and prepared as high-performance supercapacitor electrode materials <i>via</i> vacuum filtration. The 2D NiCo-MOF nanosheets serve as the main source of capacitance for t... |
39745028 | Advancing micro-nano supramolecular assembly mechanisms of natural organic matter by machine learning for unveiling environmental geochemical processes. | The nano-self-assembly of natural organic matter (NOM) profoundly influences the occurrence and fate of NOM and pollutants in large-scale complex environments. Machine learning (ML) offers a promising and robust tool for interpreting and predicting the processes, structures and environmental effects of NOM self-assembl... |
39686862 | Crafting nature's wonders: nanoarchitectonics developments in bioinspired nanocellulose-based stimuli-responsive supramolecular matrices. | Stimuli-responsive supramolecular assemblies have recently gained extensive attention in the biomedical field. Research focusing mainly on bioinspired functional supramolecular materials has shown great promise for potential drug delivery applications. Such materials can be engineered into 'smart' materials by utilizin... |
39655882 | A supramolecular diazapyrene radical assembly with NIR absorption for selective photothermal antibacterial activity. | A supramolecular radical assembly that can be induced <i>in situ</i> by facultative anaerobic bacteria has been reported and used for selective near-infrared (NIR) photothermal antibacterial action. Herein, we report the synthesis of a water-soluble diazapyrene derivative (DAPNP), which could be <i>in situ</i> initiate... |
39651782 | Computational self-assembly of a six-fold chiral quasicrystal. | Quasicrystals are unique materials characterized by long-range order without periodicity. They are observed in systems such as metallic alloys, soft matter, and particle simulations. Unlike periodic crystals, which are invariant under real-space symmetry operations, quasicrystals possess symmetry that requires descript... |
39643445 | An MST-based assay reveals new binding preferences of IFIT1 for canonically and noncanonically capped RNAs. | IFITs (interferon-induced proteins with tetratricopeptide repeats) are components of the innate immune response that bind to viral and cellular RNA targets to inhibit translation and replication. The RNA target recognition is guided by molecular patterns, particularly at the RNA 5' ends. IFIT1 preferably binds RNAs mod... |
39626887 | Cellular translational enhancer elements that recruit eukaryotic initiation factor 3. | Translation initiation is a highly regulated process that broadly affects eukaryotic gene expression. Eukaryotic initiation factor 3 (eIF3) is a central player in canonical and alternative pathways for ribosome recruitment. Here, we have investigated how direct binding of eIF3 contributes to the large and regulated dif... |
39562042 | Activity-Dependent Internalization of Glun2B-Containing NMDARs Is Required for Synaptic Incorporation of Glun2A and Synaptic Plasticity. | NMDA-type glutamate receptors are heterotetrameric complexes composed of two GluN1 and two GluN2 subunits. The precise composition of the GluN2 subunits determines the channel's biophysical properties and influences its interaction with postsynaptic scaffolding proteins and signaling molecules involved in synaptic phys... |
39540765 | Chemical diversity of cyanobacterial natural products. | Covering: 2010 to 2023Cyanobacterial natural products are a diverse group of molecules with promising biotechnological applications. This review examines the chemical diversity of 995 cyanobacterial metabolites reported from 2010 to 2023. A computational analysis using similarity networking was applied to visualize the... |
41017907 | Tethered Antigenic Suppression Shields the Hemagglutinin Head Domain and Refocuses the Antibody Response to the Stalk Domain. | Influenza has been a global health concern for the past century. Current seasonal influenza vaccines primarily elicit an antibody response that targets the immunodominant head domain of the viral glycoprotein hemagglutinin (HA), which consistently mutates due to selective pressure. To circumvent this problem, we introd... |
40735029 | Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia. | Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significant therapeutic effec... |
40584743 | Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems. | <h4>Background</h4>The current research aims to improve the oral bioavailability of ibrutinib (IBR), a class II drug with low solubility, through the formulation of nanosponges (NSPs) that incorporate IBR, utilizing Hydroxypropyl β-cyclodextrin (HPβCD) and 1,1'-carbonyldiimidazole (CDI) as cross-linking agent.<h4>Metho... |
40226348 | Stimuli-Responsive Multiacceptor Conjugated Polymers: Recent Trend and Future Direction. | Apart from the visual effects, geometric shapes of materials play an important role in their engineering and biomedical applications. Responsive materials-based patient-specific anatomical models provide better insights into the structure and pathology. Polymers are by far the most utilized class of materials for advan... |
40213235 | Comprehensive analysis the role of cuproptosis related genes in abdominal aortic aneurysm. | Immune infiltration plays an important role in the course of abdominal aortic aneurysm (AAA) development, and copper death (cuproptosis) is a new type of programmed cell death recently discovered. Currently, there are no studies on the role of cuproptosis regulating immune infiltration in AAA. We extracted a published ... |
40048613 | Histopathological Characteristics of Zonular Fibers and Lens Capsule and Their Relationship to Clinical Features in Intraocular Lens Dislocation. | <h4>Purpose</h4>To identify the histopathologic changes in the lens capsule of eyes with in-the-bag intraocular lens (IOL) dislocation.<h4>Design</h4>Pathological analysis and correlation with clinical findings.<h4>Setting</h4>Hayashi Eye Hospital (Fukuoka, Japan).<h4>Methods</h4>Specimens of twenty-five IOL-lens capsu... |
40018650 | Application of Nanomaterials in Early Imaging and Advanced Treatment of Atherosclerosis. | Atherosclerosis (AS) is a serious disease that poses a significant threat to the global population. In this review, we analyze the development of AS from multiple perspectives, aiming to elucidate its molecular mechanisms. We also focus on imaging techniques and therapeutic approaches, highlighting the crucial role of ... |
40006507 | Intestinal Probiotic Lysate Modified Bifunctional Nanoparticle for Efficient Colon Cancer Immunotherapy. | <b>Background:</b> In cancer immunotherapy, gene therapy has become a promising strategy through the introduction of immunostimulatory components into its formulation. However, ideal non-viral gene delivery platforms capable of simultaneously maintaining a high delivery efficiency and immune activation are still in dem... |
40005590 | Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host. | Dairy products often serve as matrices for delivering probiotic bacteria to humans through the diet; however, little is known about the impact of milk fat globules on the growth and survival of probiotic microorganisms. This review discusses current knowledge on the structure and functionality of the milk fat globule m... |
40002308 | Inflammasomes in Alzheimer's Progression: Nrf2 as a Preventive Target. | Current knowledge about Alzheimer's disease highlights the accumulation of β-amyloid plaques (Aβ1-42) and neurofibrillary tangles composed of hyperphosphorylated Tau, which lead to the loss of neuronal connections. Microglial activation and the release of inflammatory mediators play a significant role in the progressio... |
39997958 | Differences in Contractile Characteristics Among Various Muscle Groups in Youth Elite Female Team Handball Players Compared to a Control Group. | Muscular strength and explosiveness are generally known as factors that affect physical performance. Physical ability modeling has a profound connection with long-term athlete development and talent identification. The purpose of the current study was to investigate differences in contractile characteristics (maximal i... |
39991756 | Deficiency of Caveolin-1 Aggravates Cardiac Infarction Injury by Disturbing the Endothelial Homeostasis. | <b>Objective:</b> Caveolin-1 (Cav-1) plays a crucial role in maintaining the homeostasis of vascular endothelium. Endothelial dysfunction is involved in many ischemic diseases. However, the role of Cav-1 in myocardial infarction (MI) has not been fully elucidated. Here, this study aims to delineate the function of Cav-... |
39982278 | Seasonal Variations in the Physical Fitness of South African Premier Soccer League Players over an Annual Training Macrocycle (Nine Months). | <b>Background</b>: Anecdotal data indicate that the physical fitness of soccer players fluctuates across the season. This is often a concern for coaches, since players are expected to be at optimal fitness during matches on weekly basis across the season. <b>Objectives</b>: To analyze the physical fitness variation in ... |
39981025 | Simultaneous enhancement of efficiency, stability and stretchability in binary polymer solar cells with a three-dimensional aromatic-core tethered tetrameric acceptor. | Polymer solar cells (PSCs) leverage blend films from polymer donors and small-molecule acceptors (SMAs), offering promising opportunities for flexible power sources. However, the inherent rigidity and crystalline nature of SMAs often embrittle the polymer donor films in the constructed bulk heterojunction structure. To... |
39978896 | A carboxymethyl chitosan /trans-2-hexenal Schiff's base gel with controlled density using dynamic imine bonds: pH-controlled release and extended duration. | The volatile secondary metabolite trans-2-hexenal (T2H), an aldehyde, exhibits potent antibacterial properties. However, its high volatility presents challenges in sustaining prolonged efficacy in agricultural applications. In this study, carboxymethyl chitosan (CMCS) was utilized to immobilize T2H via Schiff's base re... |
39975840 | Comprehensive metabolite profiling and evaluation of anti-nociceptive and anti-inflammatory potencies of <i>Nypa fruticans</i> (Wurmb.) leaves: Experimental and in-silico approaches. | Globally, inflammation and pain are among the most prevalent health issues. The use of medicinal plants to alleviate these conditions is growing. This study comprehensively investigated the analgesic and anti-inflammatory properties of the ethyl-acetate extract of <i>Nypa fruticans</i> (EENF) leaves, traditionally used... |
39959493 | Prevalence, antibiotic resistance patterns, and virulence factors of <i>Staphylococcus aureus</i> isolates associated with bovine mastitis in northern Bangladesh. | <i>Staphylococcus (S.) aureus</i> is a major cause of bovine mastitis and is notorious for its capacity to resist antibiotics, presenting substantial risks to both livestock and human health. The aim of this research was to assess the prevalence of <i>S. aureus</i> in bovine mastitis cases, as well as to examine their ... |
39958389 | Discovery of Dual Ion-Electron Conductivity of Metal-Organic Frameworks via Machine Learning-Guided Experimentation. | Identifying conductive metal-organic frameworks (MOFs) with a coupled ion-electron behavior from a vast array of existing MOFs offers a cost-effective strategy to tap into their potential in energy storage applications. This study employs classification and regression machine learning (ML) to rapidly screen the CoREMOF... |
39947750 | Molecular crowding and amyloidogenic self-assembly: Emergent perspectives from modern computations. | In recent decades, the conventional protein folding paradigm has been challenged by intriguing properties of disordered peptide sequences that do not adopt stably folded conformations. Such intrinsically disordered proteins and protein regions (IDPs and IDRs) are poised uniquely in biology due to their propensity for s... |
39944918 | Studying the impact of zein microfibers on the physicochemical and microstructural properties of bi-gels based on ι-carrageenan hydrogels and beeswax oleogels. | This research presents a novel bi-gel system formed by combining zein microfiber -reinforced carrageenan hydrogels and beeswax oleogels. The main objective is investigating the impact of the interplay between zein microfibers, ι-carrageenan hydrogels, beeswax oleogels on the properties of bi-gels. The study focused on ... |
39942566 | Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from <i>Mangifera indica</i> Extracts Using UHPLC-MS/MS with <sup>1</sup>H NMR and MALDI-TOF Confirmation. | Mangiferin, a glucosyl xanthone, is a plant metabolite with promising nootropic and ergogenic properties. However, its poor and inconsistent systemic bioavailability limits its therapeutic potential. Additionally, the pharmacokinetics of mangiferin from mango leaf extract formulations remain uncharacterized in humans. ... |
39942561 | Curcumin in Ophthalmology: Mechanisms, Challenges, and Emerging Opportunities. | Ocular diseases affecting the anterior and posterior segments of the eye are major causes of global vision impairment. Curcumin, a natural polyphenol, exhibits anti-inflammatory, antioxidant, antibacterial, and neuroprotective properties, making it a promising candidate for ocular therapy. However, its clinical use is ... |
39942567 | Functional Post-Synthetic Chemistry of Metal-Organic Cages According to Molecular Architecture and Specific Geometry of Origin. | Metal-organic cages (MOCs) are discrete supramolecular entities consisting of metal nodes and organic connectors or linkers; MOCs are noted for their high porosity and processability. Chemically, they can be post-synthetically modified (PSM) and new functional groups can be introduced, presenting attractive qualities, ... |
39942555 | Chiral Separation of Mandelic Acid Derivatives Using Various Permethylated Cyclodextrin Selectors Containing Stationary Phases in GC. | A good chiral separation usually results in a trial-and-error process; however, through systematic studies, certain principles can be established to correlate structure with chiral selectivity. These principles can then be applied to other chiral separations, reducing the time of developing chiral selective analytical ... |
39942552 | Form and Function: The Factors That Influence the Efficacy of Nanomaterials for Gene Transfer to Plants. | Nanoparticle (NP)-mediated gene delivery offers a promising alternative to traditional methods in plant biotechnology, facilitating genetic transformations with enhanced precision and efficiency. This review discusses key factors influencing NP efficacy, including plant cell wall composition, DNA/NP ratios, exposure ti... |
39942548 | Effect of Glycosylation on the Enzymatic Degradation of D-Amino Acid-Containing Peptides. | The accumulation of D-amino acid-containing peptides is associated with age-related diseases such as Alzheimer's disease and cataracts, while glycosylation is an important modification of proteins and plays a key role in improving the physicochemical properties of peptides and facilitating their regulation in biologica... |
39941933 | Extraction of Biomolecules from Coffee and Cocoa Agroindustry Byproducts Using Alternative Solvents. | Coffee and cocoa agribusinesses generate large volumes of byproducts, including coffee husk, coffee pulp, parchment skin, silver skin, and cocoa bean shell. Despite the rich composition of these materials, studies on biomolecule extraction with green solvents are still scarce, and further research is needed. Extraction... |
39941353 | Future Directions in Diabetic Retinopathy Treatment: Stem Cell Therapy, Nanotechnology, and PPARα Modulation. | This narrative review focuses on innovative treatment approaches to diabetic retinopathy to meet the urgent demand for advancements in managing both the early and late stages of the disease. Recent studies highlight the potential of adipose stem cells and their secreted factors in mitigating the retinal complications o... |
39940653 | 1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer's Disease. | Currently, Alzheimer's disease (AD) is one of the most frequent forms of dementia. From a molecular perspective, the molecular characteristics that better define this disease consist of abnormal protein deposits between neuronal cells, namely senile plaques (SPs) and neurofibrillary tangles (NFTs), consisting of protei... |
39940470 | Interfacial Interlocking of Carbon Fiber-Reinforced Polymer Composites: A Short Review. | The mechanical properties of the carbon fiber-reinforced polymer composites (CFRPs) are dependent on the interfacial interaction and adhesion between carbon fibers (CFs) and polymer matrices. Therefore, it is crucial to understand how modifying the CFs can influence the properties of these composites. This review outli... |
39940240 | Glucosyl Hesperidin Supplementation Prevents Tubulointerstitial Fibrosis and Immune Activation in Diabetic Nephropathy in Mice. | <h4>Background</h4>Diabetic nephropathy (DN) is a serious condition that can result in end-stage renal failure. Recent evidence has focused on the dietary effects of polyphenols on blood glucose levels and the complications of diabetes.<h4>Objectives</h4>In this study, we investigated the protective effect of glucosyl ... |
39940134 | Surface Functionalization of Nanocarriers with Anti-EGFR Ligands for Cancer Active Targeting. | Active cancer targeting consists of the selective recognition of overexpressed biomarkers on cancer cell surfaces or within the tumor microenvironment, enabled by ligands conjugated to drug carriers. Nanoparticle (NP)-based systems are highly relevant for such an approach due to their large surface area which is amenab... |
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