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39990218 | Molecular simulation-aided self-adjuvanting nanoamplifier for cancer photoimmunotherapy. | <b>Background</b>: By leveraging the power of photodynamic therapy (PDT), photosensitizers eliminate cancer cells under specific laser irradiation and trigger systemic immune responses, a potent strategy in tumor immunotherapy. However, the accompanying tumor microenvironment induces immunosuppression, restricting the ... |
39950061 | Precise functionalization in nano-confinement: a bottom-up approach to the evolution of selective molecular receptors. | Precise molecular recognition depends on the delicate interplay between a guest molecule and a host possessing complementary functional groups. The <i>de novo</i> design of selective artificial receptors remains a formidable challenge, given the complexity of predicting these interactions. We present herein a bottom-up... |
39935897 | Advancements in functional tetrahedral DNA nanostructures for multi-biomarker biosensing: Applications in disease diagnosis, food safety, and environmental monitoring. | Deoxyribonucleic acid (DNA) offers the fundamental building blocks for the precisely controlled assemblies due to its inherent self-assembly and programmability. The tetrahedral DNA nanostructure (TDN) stands out as a widely utilized nanostructure, attracting attention for its high biostability, excellent biocompatibil... |
39916842 | Spectroscopic (FT-IR and FT-Raman) and quantum chemical study on monomer and dimer of benznidazole from DFT and molecular docking approaches. | This work presents the quantum chemical calculations of the monomer and dimer of benznidazole using density functional theory (DFT) at the B3LYP/6-311++G(d,2p) level of theory. A one-dimensional potential energy surface scan was carried out across flexible bonds to find the minimum energy structure. The structure with ... |
39911752 | Advancements in electrochemical sensingTechnology for Heavy Metal Ions Detection. | Most heavy metal ions are carcinogenic and non-biodegradable, posing threats to ecological balance and human health in trace amount. Therefore, there is a pressing demand for rapid and dependable detection technologies. Electrochemical sensing technology distinguishes itself with its ease of use and swiftness, renderin... |
39911404 | Combined Swelling and Metal Infiltration: Advancing Block Copolymer Pattern Control for Nanopatterning Applications. | Block copolymer (BCP) patterning is a well-established self-assembly technique for developing surfaces with regular and controllable nanosized features. This method relies on the microphase separation of a BCP film and subsequent infiltration with inorganic species. The BCP film serves as a template, leaving behind ino... |
39906227 | The grapevine ABC transporter B family member 15 is a <i>trans</i>-resveratrol transporter out of grapevine cells. | Stilbenes, particularly <i>trans</i>-resveratrol, play a highly relevant defense role in grapevines as phytoalexin is induced in response to stress. Metabolism and transport of stilbenes can be conveniently investigated in grapevine cell culture since large amounts of <i>trans</i>-resveratrol are accumulated in the ext... |
39906151 | Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy. | Carbon monoxide (CO) based gas therapy has recently garnered significant attention due to its remarkable therapeutic effects for various major diseases. However, the primary challenge in gas therapy is the effective delivery of gas prodrug to targeted sites, as well as achieving precise spatial-temporal control over th... |
39906150 | Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening. | Protein arginine methyltransferases (PRMTs) play crucial roles in gene regulation, signal transduction, mRNA splicing, DNA repair, cell differentiation, and embryonic development. Due to its significant impact, PRMTs is a target for the prevention and treatment of various diseases. Among the PRMT family, PRMT1 is the m... |
39902278 | Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties. | Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated in diseases, particularly cancer. ... |
39902211 | Chinese cabbage orphan gene <i>BR3</i> confers bolting resistance to <i>Arabidopsis</i> through the gibberellin pathway. | Premature bolting reduces the yield and quality of Chinese cabbage, making bolting resistance gene identification crucial for breeding superior and stable varieties. In this study, we identified an orphan gene <i>BOLTING RESISTANCE 3</i> (<i>BR3</i>) that positively regulates bolting resistance in <i>Arabidopsis thalia... |
39902185 | Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy. | Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have significantly enhanced the design, prediction, and optimization of mRNA v... |
39902172 | Harnessing nanotechnology for cancer treatment. | Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at the nanoscale, researchers have developed nanocarriers capable of targeted drug delivery, improving ... |
39897025 | Updated review of research on the role of the gut microbiota and microbiota-derived metabolites in acute pancreatitis progression and inflammation-targeted therapy. | Acute pancreatitis (AP) is characterized by autodigestion of the pancreas, and some patients may rapidly progress to systemic inflammation, pancreatic necrosis, and multi-organ failure. Numerous studies have detailed the bidirectional communication networks between the pancreas and the intestinal microbiota, as well as... |
39886445 | Rational pore engineering reveals the relative contribution of enzymatic sites and self-assembly towards rapid ferroxidase activity and mineralization: impact of electrostatic guiding and cage-confinement in bacterioferritin. | The self-assembled ferritin protein nanocage plays a pivotal role during oxidative stress, iron metabolism, and host-pathogen interaction by executing rapid iron uptake, oxidation and its safe-storage. Self-assembly creates a nanocompartment and various pores/channels for the uptake of charged substrates (Fe<sup>2+</su... |
39879671 | Antimicrobial and antibiofilm activity of prepared thymol@UIO-66 and thymol/ZnONPs@UIO-66 nanoparticles against Methicillin-resistant Staphylococcus aureus: A synergistic approach. | This study introduces a novel approach to enhance the antibacterial properties of UIO-66 by incorporating both Thymol and ZnO nanoparticles within its framework which represents a significant advancement like exhibiting a synergistic antibacterial effect, providing a prolonged and controlled release, and mitigating cyt... |
39874794 | Highly sensitive fluorescent aptasensor based on magnetic metal-organic framework for aflatoxin B1 detection. | Aflatoxin B1 (AFB1) has strong carcinogenicity, mutagenicity, and teratogenicity even at low concentrations, presenting a major risk to food safety and human health, hence, it is crucial to develop a sensitive detection technique for AFB1. Consequently, cadmium telluride (CdTe) quantum dots conjugated with AFB1 aptamer... |
39872724 | Utilizing FRET-based Biosensors to Measure Cellular Phosphate Levels in Mycorrhizal Roots of <i>Brachypodium distachyon</i>. | Arbuscular mycorrhizal (AM) fungi engage in symbiotic relationships with plants, influencing their phosphate (Pi) uptake pathways, metabolism, and root cell physiology. Despite the significant role of Pi, its distribution and response dynamics in mycorrhizal roots remain largely unexplored. While traditional techniques... |
39864388 | Homologous metal-organic complexes reconstructed oxy-hydroxide heterostructures as efficient oxygen evolution electrocatalysts. | It is imperative to investigate more cost-effective, long-lasting, efficient, and reliable non-noble metal electrocatalysts for the oxygen evolution reaction (OER) in hydrogen production via water splitting. Metal-organic complexes have been extensively researched and utilized for this purpose, yet their transformation... |
39862755 | Tumor-targeted near-infrared/ultraviolet-triggered photothermal/gas therapy nanoplatform for effective cancer synergistic therapy. | The integration of photothermal therapy (PTT) and gas therapy (GT) on a nanoplatform shows great potential in cancer treatment. In this paper, a tumor-targeted near-infrared/ultraviolet (NIR/UV) triggered PTT/GT synergistic therapeutic nanoplatform, PB-CD-PLL(NF)-FA, was designed based on Prussian blue (PB) nanoparticl... |
39862674 | MOF scaffold for anchoring platinum-nickel nanoparticles with enhanced oxidase-like activity to improve lateral flow immunoassay diagnosis. | Noble metal nanoparticles have attracted tremendous attention as the promising signal reporters for catalytic-colorimetric lateral flow immunoassay (LFIA). However, it remains great challenges for improving their stability and catalytic activity. Herein, first, a kind of porphyrinic based metal-organic framework (MOF) ... |
39861489 | Differential Enhancement of Fat-Soluble Vitamin Absorption and Bioefficacy via Micellization in Combination with Selected Plant Extracts In Vitro. | <b>Background/Objectives:</b> Individuals with special metabolic demands are at risk of deficiencies in fat-soluble vitamins, which can be counteracted via supplementation. Here, we tested the ability of micellization alone or in combination with selected natural plant extracts to increase the intestinal absorption and... |
39861485 | Spirulina Supplementation Alleviates Intense Exercise-Induced Damage and Modulates Gut Microbiota in Mice. | <h4>Background</h4><i>Spirulina</i>, which are filamentous cyanobacteria, have gained significant popularity in the food industry, medicine, and aquaculture.<h4>Methods</h4>In this study, our objective was to explore the influence of <i>Spirulina</i> on the gut microbiota and exercise capacity of mice undergoing high-i... |
39861323 | Antimicrobial Activity of UV-Activated and Cysteamine-Grafted Polymer Foils Against Bacteria and Algae. | Surface modification of various polymer foils was achieved by UV activation and chemical grafting with cysteamine to improve surface properties and antimicrobial efficacy. UVC activation at 254 nm led to changes in surface wettability and charge density, which allowed the introduction of amino and thiol functional grou... |
39861324 | An Overview of Potential Applications of Environmentally Friendly Hybrid Polymeric Materials. | The applications of polymeric materials are being constantly reviewed and improved. In the present world, the word hybrid, and the general idea of combining two or more inherently different approaches, designs, and materials is gaining significant attention. The area of sustainable materials with a low environmental im... |
39861327 | Characterization and Adsorption Behavior of Newly Synthesized Aminated Cellulose with Jeffamine EDR148 Towards Ni(II), Cu(II), and Pb(II) Heavy Metal Ions. | Industrial wastewater containing heavy metal ions presents serious economic risk to the environment. In this study, a novel compound of aminated cellulose with jeffamine EDR148 was prepared to improve cellulose's adsorptive behavior towards metal ions. This study undertook a straightforward and efficient cellulose modi... |
39861315 | Electrospinning Membrane with Polyacrylate Mixed Beta-Cyclodextrin: An Efficient Adsorbent for Cationic Dyes. | A simple and non-chemical binding nanofiber (<i>β</i>-CD/PA) adsorbent was obtained by electrospinning a mixture of <i>β</i>-cyclodextrin (<i>β</i>-CD) and polyacrylate (PA). The cationic dyes in wastewater were removed by the host-guest inclusion complex of the <i>β</i>-cyclodextrin and the electrostatic interaction b... |
39861320 | Recent Advancements of Bio-Derived Flame Retardants for Polymeric Materials. | The sustainable flame retardancy of polymeric materials is a key focus for the direction of the next generation in the field of fire safety. Bio-derived flame retardants are gaining attention as environmentally friendly additives due to their low ecological impact and decreasing costs. These compounds can enhance char ... |
39861318 | Nanoparticle-Doped Antibacterial and Antifungal Coatings. | Antimicrobial polymeric coatings rely not only on their surface functionalities but also on nanoparticles (NPs). Antimicrobial coatings gain their properties from the addition of NPs into a polymeric matrix. NPs that have been used include metal-based NPs, metal oxide NPs, carbon-based nanomaterials, and organic NPs. C... |
39860654 | Prediction Model for POstoperative atriaL fibrillAtion in caRdIac Surgery: The POLARIS Score. | <b>Background</b>: New-onset postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery, occurring approximately in one-third of the patients. This study considered all-comer patients who underwent cardiac surgery to build a predictive model for POAF. <b>Methods</b>: A total of 3467 ... |
39860649 | Comprehensive Review of Lipid Management in Chronic Kidney Disease and Hemodialysis Patients: Conventional Approaches, and Challenges for Cardiovascular Risk Reduction. | <b>Background/Objectives</b>: Lipid disorders are very prevalent in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), leading to heightened cardiovascular risk. This review examines the effectiveness of lipid-lowering agents in these populations and explores gaps in the current research. T... |
39860297 | The Synthesis, Crystal Structure, Modification, and Cytotoxic Activity of α-Hydroxy-Alkylphosphonates. | A series of α-hydroxy-alkylphosphonates and α-hydroxy-alkylphosphine oxides were synthesized by the Pudovik reaction of acetaldehyde and acetone with dialkyl phosphites or diarylphosphine oxides. The additions were performed in three different ways: in liquid phase using triethylamine as the catalyst (1), on the surfac... |
39860291 | Colorimetric Detection of Dopamine Based on Peroxidase-like Activity of β-CD Functionalized AuNPs. | Catalytically active nanomaterials, or nanozymes, have gained significant attention as alternatives to natural enzymes due to their low cost, ease of preparation, and enhanced stability. Because of easy preparation, excellent biocompatibility, and unique optoelectronic properties, gold nanoparticles (AuNPs) have attrac... |
39860299 | The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives. | A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one structure was synthesized through efficient Thorpe-Ziegler and cyclization reactions. The thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one deriva... |
39859928 | Structural Regulation and Performance Enhancement of Carbon-Based Supercapacitors: Insights into Electrode Material Engineering. | The development of carbon-based supercapacitors is pivotal for advancing high energy and power density applications. This review provides a comprehensive analysis of structural regulation and performance enhancement strategies in carbon-based supercapacitors, focusing on electrode material engineering. Key areas explor... |
39859927 | Films Based on Chitosan/Konjac Glucomannan Blend Containing Resveratrol for Potential Skin Application. | Biopolymers represent a significant class of materials with potential applications in skin care due to their beneficial properties. Resveratrol is a natural substance that exhibits a range of biological activities, including the scavenging of free radicals and anti-inflammatory and anti-aging effects. In this study, ch... |
39859569 | Curcumin Solubility and Bioactivity Enhancement Through Amorphization with Tryptophan via Supercritical Fluid Technology. | Curcumin, a compound known for its antioxidant and neuroprotective properties, faces challenges due to its low water solubility, which can limit its effectiveness. One effective method to address this issue is through amorphization. Incorporating curcumin into a polymeric matrix to form amorphous solid dispersions is a... |
39859562 | Proteins and DNA Sequences Interacting with Tanshinones and Tanshinone Derivatives. | Tanshinones, biologically active diterpene compounds derived from <i>Salvia miltiorrhiza</i>, interact with specific proteins and DNA sequences, influencing signaling pathways in animals and humans. This study highlights tanshinone-protein interactions observed at concentrations achievable in vivo, ensuring greater phy... |
39859560 | De Novo <i>DNM1L</i> Pathogenic Variant Associated with Lethal Encephalocardiomyopathy-Case Report and Literature Review. | Pathogenic variants in <i>DNM1L</i>, encoding dynamin-like protein-1 (DRP1), cause a lethal encephalopathy. DRP1 defective function results in altered mitochondrial networks, characterized by elongated/spaghetti-like, highly interconnected mitochondria. We validated in yeast the pathogenicity of a de novo <i>DNM1L</i> ... |
39857823 | Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications. | Natural cyclic peptides, a diverse class of bioactive compounds, have been isolated from various natural sources and are renowned for their extensive structural variability and broad spectrum of medicinal properties. Over 40 cyclic peptides or their derivatives are currently approved as medicines, underscoring their si... |
39856997 | Sustainable Extraction Technology of Fruit and Vegetable Residues as Novel Food Ingredients. | <h4>Background</h4>Fruit and vegetable waste (FVW) is a global waste issue with environmental impacts. It contains valuable compounds such as polysaccharides, polyphenols, proteins, vitamins, pigments, and fatty acids, which can be extracted for food applications. This study aims to review sustainable extraction method... |
39855091 | Designing pillar-layered metal-organic frameworks with photo-induced electron transfer interactions between ligands for enhanced photodynamic sterilization and photocatalytic degradation of dyes and antibiotics. | Pollution caused by antibiotics, bacteria, and organic dyes presents global public health challenges, posing serious risks to human health. Consequently, new, efficient, fast, and simple photocatalytic systems are urgently required. To this end, 2,7-di(pyridin-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone ... |
39855089 | Enhancing ionic conductivity and expanding the electrochemical window in polymer electrolytes via ferroelectric-metal-organic-frameworks to manipulate charge spatial distribution. | Poly (ethylene oxide) (PEO)-based polymer electrolytes have promising applications in all-solid-state lithium metal batteries. However, their wide range of practical applications is severely limited by their relatively low room temperature lithium ion conductivity and narrow electrochemical window. In this paper, based... |
39852760 | A Cu(I)-Based MOF with Nonlinear Optical Properties and a Favorable Optical Limit Threshold. | The exploitation of high-performance third-order nonlinear optical (NLO) materials that have a favorable optical limit (OL) threshold is essential due to a rise in the application of ultra-intense lasers. In this study, a Cu-based MOF (denoted as Cu-bpy) was synthesized, and its third-order NLO and OL properties were i... |
39852051 | Influence of Electrostatic Interactions on the Self-Assembly of Charged Peptides. | Peptides can be designed to self-assemble into predefined supramolecular nanostructures, which are then employed as biomaterials in a range of applications, including tissue engineering, drug delivery, and vaccination. However, current self-assembling peptide (SAP) hydrogels exhibit inadequate self-healing capacities a... |
39852050 | Batch Adsorption of Orange II Dye on a New Green Hydrogel-Study on Working Parameters and Process Enhancement. | A new green hydrogel consisting of cherry stone (CS) powder and sodium alginate (SA) was synthesized through physical crosslinking. The product had a mean diameter of 3.95 mm, a moisture content of 92.28%, a bulk density of 0.58 g/cm<sup>3</sup>, and a swelling ratio of 45.10%. The analyses of its morphological structu... |
39851366 | Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia. | Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail to adequately address the complexity of CLI, necessitating t... |
39842581 | Novel metal-organic framework coated with chitosan-κ-carrageenan as a platform for curcumin delivery to cancer cells. | Metal-organic frameworks (MOFs) have shown great promise as pH-responsive drug delivery systems, with considerable potential for targeted cancer therapy. In this study, we synthesized a novel curcumin-loaded MOF, named UWO-2 (CUR@UWO-2), and developed its biocomposite form, CS-κ-Cr/CUR@UWO-2, by coating it with chitosa... |
39842572 | Electrospun nanofiber chitosan/polyvinyl alcohol loaded with metal organic framework nanofiber for efficient adsorption and removal of industrial dyes from waste water: Adsorption isotherm, kinetic, thermodynamic, and optimization via Box-Behnken design. | Dyes can seriously harm human health because they linger or break down in the environment and find their way into drinking water through the water cycle. Examples of the most important interactions between MOFs and dyes are provided, and an effort is made to comprehend how surface charge and size compatibility affect t... |
39840300 | Recent advances in synthesis and application of Magnéli phase titanium oxides for energy storage and environmental remediation. | High-temperature reduction of TiO<sub>2</sub> causes the gradual formation of structural defects, leading to oxygen vacancy planar defects and giving rise to Magnéli phases, which are substoichiometric titanium oxides that follow the formula Ti <sub><i>n</i></sub> O<sub>2<i>n</i>-1</sub>, with 4 ≤ <i>n</i> ≤ 9. A high ... |
39839223 | Investigation of the photocatalytic potential of C/N-co-doped ZnO nanorods produced <i>via</i> a mechano-thermal process. | Doping in pure materials causes vital alterations in opto-electrical and physicochemical characteristics, which enable the produced doped material to be highly efficient and effective. The current work focused on the synthesis of C/N-co-doped-ZnO nanorods <i>via</i> a facile, eco-friendly, and solvent-free mechano-ther... |
39837332 | Structure-guided insights into TIR-mediated bacterial and eukaryotic immunity. | Within the course of evolution, TIR (Toll/interleukin-1 receptor) domains acquired a myriad of functional specificities. This has significantly added to their well-established roles in innate immune signaling. These additional functions include nicotinamide adenine dinucleotide (NAD)(P) hydrolase, RNA/DNA nuclease (in ... |
39835211 | Unveiling the structural aspects of novel azo-dyes with promising anti-virulence activity against MRSA: a deep dive into the spectroscopy <i>via</i> integrated experimental and computational approaches. | A novel series of azo dyes was successfully synthesized by combining amino benzoic acid and amino phenol on the same molecular framework <i>via</i> azo linkage. The structural elucidation of these dyes was carried out using various spectroscopic techniques, including UV-vis, FT-IR, NMR spectroscopy, and HRMS. Surprisin... |
39833939 | Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response. | Porcine reproductive and respiratory syndrome virus (PRRSV) presents significant economic challenges to the global pork industry due to its ability to mutate rapidly. The current commercial vaccines have limited effectiveness, and there are strict restrictions on the use of antiviral chemical drugs. Therefore, it is ur... |
39833846 | Recent advances in self-targeting natural product-based nanomedicines. | Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases. Natural products derived from traditional Chinese medicine have their own tar... |
39833840 | Functional analysis of the type II toxin-antitoxin system ParDE in Streptococcus suis serotype 2. | Streptococcus suis (S. suis) is a major pathogen in swine and poses a potential zoonotic threat, which may cause serious diseases. Many toxin-antitoxin (TA) systems have been discovered in S. suis, but their functions have not yet been fully elucidated. In this study, an auto-regulating type II TA system, ParDE, was id... |
39833568 | UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing. | The use of single-cell combinatorial indexing sequencing via droplet microfluidics presents an attractive approach for balancing cost, scalability, robustness and accessibility. However, existing methods often require tailored protocols for individual modalities, limiting their automation potential and clinical applica... |
39833508 | Pillar[n]arene-Based Supramolecular Nanodrug Delivery Systems for Cancer Therapy. | Macrocyclic supramolecular materials play an important role in encapsulating anticancer drugs to improve the anticancer efficiency and reduce the toxicity to normal tissues through host-guest interactions. Among them, pillar[n]arenes, as an emerging class of supramolecular macrocyclic compounds, have attracted increasi... |
39833514 | Synthesis of pillar-layered metal-organic frameworks with variable backbones through sequence control. | The properties and functions of metal-organic frameworks (MOFs) can be tailored by tuning their structure, including their shape, porosity and topology. However, the design and synthesis of complex structures in a predictable manner remains challenging. Here we report the preparation of a series of isomeric pillar-laye... |
39833469 | Fascin structural plasticity mediates flexible actin bundle construction. | Fascin cross-links actin filaments (F-actin) into bundles that support tubular membrane protrusions including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration during metastasis, and fascin inhibitors are under development as cancer therapeutics. Here, we use cryo-EM, cryo-electron tomograp... |
39833468 | Harnessing antiviral RNAi therapeutics for pandemic viruses: SARS-CoV-2 and HIV. | Using the knowledge from decades of research into RNA-based therapies, the COVID-19 pandemic response saw the rapid design, testing and production of the first ever mRNA vaccines approved for human use in the clinic. This breakthrough has been a significant milestone for RNA therapeutics and vaccines, driving an expone... |
39833467 | Self-assembly of multi-arm star PEG containing TXA9 into nanoparticle for the efficient chemotherapy of NSCLC. | TXA9, a cardiac glycoside isolated from the root of Streptocaulon juventas (Lour.) Merr., with better therapeutic effect in vitro on non-small cell lung cancer (NSCLC) than cisplatin and has no toxic side effects on the body. However, poor water solubility and rapid metabolism limited its clinical application. Multi-ar... |
39833393 | Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries. | Evaluate the prognostic performance of the lactate-to-albumin ratio (LAR) for complications in children 5 years of age or younger with second and/or third degree burn injuries during hospitalization in the intensive care unit of a hospital in Lima, Peru. In this retrospective cohort study, we conducted prognostic tests... |
39833342 | Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A. | The poor prognosis of pancreatic cancer is often attributed to difficulties of early detection due to a lack of appropriate risk factors. Previously, we demonstrated the presence of Enterococcus faecalis (E. faecalis) in pancreatic juice and tissues obtained from patients with cancers of the duodeno-pancreato-biliary r... |
39833336 | Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies. | Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with the burden surpassing one million cases. This disease leads to considerable morbidity and mortality, predominantly within tropical and subtropical regions. The current therape... |
39833201 | Preparation of ZnAl layered double hydroxides supported by silica for the treatment of Cr(VI) and Cu(II) in aqueous solution. | A novel adsorbent ZnAl-LDHs/SiO<sub>2</sub> (ZA/SiO<sub>2</sub>) was prepared by blending urea mixture of ZnSO<sub>4</sub> and Al<sub>2</sub>(SO<sub>4</sub>)<sub>3</sub> while using SiO<sub>2</sub> as a support form. The adsorption properties of ZA/SiO<sub>2</sub> for the removal of toxic metal ions (Cu(II) and Cr(VI))... |
39833198 | Room-temperature phosphorescent transparent wood. | Transparent wood with high transmittance and versatility has attracted great attention as an energy-saving building material. Many studies have focused on luminescent transparent wood, while the research on organic afterglow transparent wood is an interesting combination. Here, we use luminescent difluoroboron β-diketo... |
39833186 | Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic. | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has imposed substantial challenges on our society due to the COVID-19 pandemic. This virus relies heavily on its surface glycoprotein (S-glycoprotein) to facilitate attachment, fusion, and entry into host cells. While the nucleoprotein (N) in the ribonucl... |
39833159 | Fabrication and modulation of flexible electromagnetic metamaterials. | Flexible electromagnetic metamaterials are a potential candidate for the ideal material for electromagnetic control due to their unique physical properties and structure. Flexible electromagnetic metamaterials can be designed to exhibit specific responses to electromagnetic waves within a particular frequency range. Re... |
39833158 | Instantaneous self-recovery and ultra-low detection limit hydrogel electronic sensor for temporomandibular disorders intelligent diagnosis. | Temporomandibular disorders (TMD) intelligent diagnosis promises to elevate clinical efficiency and facilitate timely TMD management for patients. However, development of TMD intelligent diagnostic tools with high accuracy and sensitivity presents challenges, particularly in sensing minute deformations and ensuring rap... |
39833157 | Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity. | The inherent antigen cross-reactivity of the T cell receptor (TCR) is balanced by high specificity. Surprisingly, TCR specificity often manifests in ways not easily interpreted from static structures. Here we show that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen and its wild-type (WT... |
39833145 | A single residue switch mediates the broad neutralization of Rotaviruses. | Broadly neutralizing antibodies (bNAbs) could offer escape-tolerant and lasting protection against viral infections and therefore guide development of broad-spectrum vaccines. The increasing challenge posed by viral evolution and immune evasion intensifies the importance of the discovery of bNAbs and their underlying n... |
39833094 | Toluidine blue O demethylated photoproducts as type II photosensitizers. | Toluidine blue O (TBO) is a type I-type II photosensitizer that has shown good efficacy and selectivity in antimicrobial and anticancer photodynamic therapy applications. However, its complex photochemistry with multiple photoproducts hinders its application as a photosensitizer. We have previously described the mechan... |
39832794 | Tailoring Chirality and Optimizing Enantioselective Recognition in Strategic Defect Engineering of Chiral Metal-Organic Frameworks. | Introducing chiral molecules into metal-organic frameworks (MOFs) to obtain chiral MOFs (CMOFs), the tunability of their structures makes them a highly anticipated class of chiral materials for electrochemical sensing. However, the structure of CMOFs is often limited by synthesis challenges, and introducing chiral mole... |
39832187 | Air-liquid interface culture combined with differentiation factors reproducing intestinal cell structure formation in vitro. | Reproducing intestinal cells in vitro is important in pharmaceutical research and drug development. Caco-2 cells and human iPS cell-derived intestinal epithelial cells are widely used, but few evaluation systems can mimic the complex crypt-villus-like structure. We attempted to generate intestinal cells mimicking the t... |
39832085 | Coumarin derivatives containing the 1,3,4 oxadiazole/thiadiazole moiety discovered as potential anti-tobacco mosaic virus agents. | In this paper, a series of oxadiazole/thidiazole containing coumarin derivative derivatives were designed, synthesized and characterized using NMR and HRMS. The evaluation of antiviral activity revealed that some of the synthesized compounds exhibited good in vivo antiviral efficacy against tobacco mosaic virus (TMV). ... |
39831810 | Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function. | Redox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause of myocardial ischemia‒reperfusion (I/R) injury. In the exploration of reducing myocardial I/R injury, it is found that protecting m... |
39831768 | Protective immunity induced by a novel P1 adhesin C-terminal anchored mRNA vaccine against <i>Mycoplasma pneumoniae</i> infection in BALB/c mice. | <i>Mycoplasma pneumoniae</i> (Mp), a unique pathogen devoid of a cell wall, is naturally impervious to penicillin antibiotics. This bacterium is the causative agent of <i>M. pneumoniae</i> pneumonia, an acute pulmonary affliction marked by interstitial lung damage. Non-macrolide medications may have potential adverse e... |
39831424 | Effect of Nitrogen and Phosphorus Doping of Reduced Graphene Oxide in the Hydrogen Evolution Catalytic Activity of Supported Ru Nanoparticles. | Three different cathodic materials for the hydrogen evolution reaction (HER) consisting of Ru nanoparticles (NPs) supported onto a bare and two doped reduced graphene oxides (r-GO) have been studied. Ru NPs have been synthesized in situ by means of the organometallic approach in the presence of each reduced graphene su... |
39829306 | Global research trends on nanotechnology and colorectal cancer: a two-decade analysis. | <h4>Introduction</h4>Colorectal cancer (CRC) remains a serious threat to humans worldwide. In this study, we used bibliometric analysis of the scientific literature to assess the trends and prospects of nanotechnology applications in CRC.<h4>Materials and methods</h4>We used the Web of Science Core Collection database ... |
39828703 | Near telomere-to-telomere genome assemblies of Silkie Gallus gallus and Mallard Anas platyrhynchos restored the structure of chromosomes and "missing" genes in birds. | <h4>Background</h4>Chickens and ducks are vital sources of animal protein for humans. Recent pangenome studies suggest that a single genome is insufficient to represent the genetic information of a species, highlighting the need for more comprehensive genomes. The bird genome has more than tens of microchromosomes, but... |
39828684 | Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tolerance. | <h4>Background</h4>Low temperatures disrupt nitrogen metabolism in tobacco, resulting in lower nicotine content in the leaves. 24-epibrassinolide (EBR) is a widely used plant growth regulator known for its roles in enhancing cold tolerance and nitrogen metabolism. Nevertheless, it remains unclear whether EBR enhances l... |
39828682 | Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites. | The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urgent need to develop broader-spectrum HPV vaccines. This study addresses this need by focusing on HR-HPV types 53, 56, and 66, which are not currently targeted by existing vaccines. It introduces an ... |
39810617 | Controllable Self-Assembly Morphologies of PPV-Based Block Copolymers. | Poly(p-phenylenevinylene) (PPV) is a classic semiconducting π-conjugated polymer with outstanding optical and electronic properties, which shows important applications in the fields of optoelectronic, such as organic light-emitting diodes (OLEDs), organic solar cells (OSCs), and organic field-effect transistors (OFETs)... |
39794304 | Click Hydrogels to Assess Stiffness-Induced Activation of Pancreatic Cancer-Associated Fibroblasts and Its Impact on Cancer Cell Spreading. | Pancreatic ductal adenocarcinoma (PDAC) is marked by significant desmoplastic reactions, or the accumulation of excessive extracellular matrices. PDAC stroma has abnormally high stiffness, which alters cancer cell behaviors and creates a barrier for effective drug delivery. Unfortunately, clinical trials using a combin... |
39794293 | Regulation of TADF by Internal and External Heavy Atom Effect in D-A MOF for Heterocrystal based Temperature-Compensated Photonic Device. | The application of temperature-compensated photonic device is hampered by poor accuracy and overly simplistic functions of propagation in photonic integrated circuits (PICs) field. Herein, we report a new library of donor-acceptor metal-organic framework (D-A MOF) with thermally activated delayed fluorescence (TADF) an... |
39794294 | Gas-Releasing Polymer Tubesomes: Boosting Gas Delivery of Nanovehicles via Membrane Stretching. | Hydrogen sulfide (H<sub>2</sub>S), one of the three gas signaling molecules, not only plays a vital role in mediating a series of cellular activities but also manifests exciting applications in clinical therapy. However, one main obstacle in using H<sub>2</sub>S as a gaseous therapeutic agent is to realize on-demand st... |
39740085 | Molecular Insights into the Heme-Binding Potential of Plant NCR247-Derived Peptides. | Heme is involved in many critical processes in pathogenic bacteria as iron acquisition by these microorganisms is achieved by either direct uptake of heme or use of heme-binding proteins called hemophores. Exploring the underlying mechanisms on a molecular level can open new avenues in understanding the host-pathogen i... |
39714366 | Phytochemistry, Antibacterial and Antioxidant Activities of Grewia lasiocarpa E. Mey. Ex Harv. Fungal Endophytes: A Computational and Experimental Validation Study. | The genus Grewia are well-known for their medicinal properties and are widely used in traditional remedies due to their rich phytochemical composition and potential health benefits. This study isolated and characterized five endophytic fungi from Grewia lasiocarpa E. Mey. Ex Harv. and evaluated their in vitro antibacte... |
39670345 | Unraveling the Molecular Basis for G-Quadruplex-Binders to ALS/FTD-Associated G4C2 Repeats of the C9orf72 Gene. | The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of an abnormal number of intronic GGGGCC (G<sub>4</sub>C<sub>2</sub>) repetitions in the C9orf72 gene, which has been proposed to drive ALS/FTD pathogenesis. Recently, it has been shown that such G... |
39663992 | Autocatalytic Nucleation and Self-Assembly of Inorganic Nanoparticles into Complex Biosimilar Networks. | Self-replication of bioorganic molecules and oil microdroplets have been explored as models in prebiotic chemistry. An analogous process for inorganic nanomaterials would involve the autocatalytic nucleation of metal, semiconductor, or ceramic nanoparticles-an area that remains largely uncharted. Demonstrating such sys... |
39589788 | Host molecules inside metal-organic frameworks: host@MOF and guest@host@MOF (Matrjoschka) materials. | The controllable encapsulation of host molecules (such as porphyrin, phthalocyanine, crown ether, calixarene or cucurbituril organic macrocycles, cages, metal-organic polyhedrons and enzymes) into the pores of metal-organic frameworks (MOFs) to form host-in-host (host@MOF) materials has attracted increasing research in... |
39503364 | Controllable transformation of UCST and LCST behaviors in polyampholyte hydrogels enabled by an association-disassociation theory-based switch mechanism. | The potential temperature-sensitive characteristics of polyampholyte hydrogels have not been explored yet, despite their excellent mechanical properties and universality as supramolecular materials. Here, polyampholyte hydrogels were prepared with anionic and cationic monomers at high concentrations and their thermosen... |
39499027 | Chiral helix amplification and enhanced bioadhesion of two-component low molecular weight hydrogels regulated by OH to eradicate MRSA biofilms. | The supramolecular chemistry of small chiral molecules has attracted widespread attention owing to their similarity to natural assembly codes. Two-component low-molecular-weight (LMW) hydrogels are crucial as they form helical structures <i>via</i> chirality transfer, enabling diverse functions. Herein, we report a pai... |
39974265 | Bell's Palsy: Description, Diagnosis, and Current Management. | Bell's palsy, also known as idiopathic facial paralysis, is a neuropathy that affects the seventh cranial nerve, the facial. Its presentation is unmistakable by a trained clinician. It usually presents with unilateral facial weakness, reduced forehead wrinkling, nasolabial fold flattening, drooping of the corner of the... |
39968427 | Potential Adverse Effects of Sugammadex Administration: A Scoping Review. | Sugammadex, a novel agent for reversing neuromuscular blockade, has become the preferred method for reversal over the combination of neostigmine and glycopyrrolate due to its lower risk of adverse effects and high efficacy in reversing paralytic agents. Its primary theorized adverse effect is its ability to bind to ste... |
39911372 | DNA-based hydrogels for bone regeneration: A promising tool for bone organoids. | DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These hydrogels facilitate the formation of spatial bone structures through bulk hydrogel fabricating, microsphere formatting, and 3D printing. Furthermore, the bone microenvironment can be finely tuned by... |
39906202 | A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression. | Triple-negative breast cancer (TNBC) is the most malignant type of breast cancer and lacks effective targeted therapeutic drugs, resulting in a high recurrence rate and worse outcome. In this study, bioinformatic analysis and a series of experiments demonstrated that MOCR2 was highly expressed in TNBC and closely assoc... |
39901950 | Deep eutectic solvent-based magnetic molecular nanomaterials coupled with fluorescent carbon dots as a new strategy to highly enrich and sensitively detect doxycycline in food matrices. | The highly selective enrichment and sensitive detection of antibiotics in food are crucial for human health, environmental monitoring, and management. In this study, deep eutectic solvents (DESs) were used as eco-friendly functional monomers, a magnetic molecular nanomaterial (DES-MMIP) coupled with carbon dots (CDs) w... |
39860936 | A Label-Free Colorimetric Aptasensor for Flavokavain B Detection. | Flavokavain B (FKB), a hepatotoxic chalcone from <i>Piper methysticum</i> (kava), has raised safety concerns due to its role in disrupting redox homeostasis and inducing apoptosis in hepatocytes. Conventional chromatographic methods for FKB detection, while sensitive, are costly and impractical for field applications. ... |
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