id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
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39861607 | Dual Regulation of Ionic Effect on <i>Zostera marina</i> L. Seed Germination and Leaf Differentiation in Low-Salinity Conditions. | Low-salinity conditions are generally used in land-based cultivation to promote the germination and growth of <i>Zostera marina</i> L. and to improve the restoration effect of seagrass beds. Different salinity conditions lead to morphological and physiological differences. To investigate the impacts of salinity and osm... |
39861301 | Multifunctional Biological Performance of Electrospun PCL Scaffolds Formulated with Silver Sulfide Nanoparticles. | Our work describes the green synthesis of silver sulfide nanoparticles (Ag<sub>2</sub>S NPs) and their formulation into polycaprolactone fibers (PCL), aiming to improve the multifunctional biological performance of PCL membranes as scaffolds. For this purpose, an extract of rosemary (<i>Salvia rosmarinus</i>) was emplo... |
39860255 | Antiviral Activity and Underlying Mechanism of <i>Moslae herba</i> Aqueous Extract for Treating SARS-CoV-2. | Despite the widespread use of COVID-19 vaccines, there is still a global need to find effective therapeutics to deal with the variants of SARS-CoV-2. <i>Moslae herba</i> (MH) is a herbal medicine credited with antiviral effects. This study aims to investigate the antiviral effects and the underlying mechanism of aqueou... |
39860253 | Hemoglobin Variants as Targets for Stabilizing Drugs. | Hemoglobin is an oxygen-transport protein in red blood cells that interacts with multiple ligands, e.g., oxygen, carbon dioxide, carbon monoxide, and nitric oxide. Genetic variations in hemoglobin chains, such as those underlying sickle cell disease and thalassemias, present substantial clinical challenges. Here, we re... |
39860256 | Mononuclear Aluminum-Fluoride Ions, AlF<i><sub>x</sub></i><sup>(+/-)</sup>-Study of Plausible Frameworks of Complexes with Biomolecules and Their In Vitro Toxicity. | The importance of fluorine and aluminum in all aspects of daily life has led to an enormous increase in human exposure to these elements in their various forms. It is therefore important to understand the routes of exposure and to investigate and understand the potential toxicity. Of particular concern are aluminum-flu... |
39860247 | Self-Assembly Strategy for Synthesis of WO<sub>3</sub>@TCN Heterojunction: Efficient for Photocatalytic Degradation and Hydrogen Production via Water Splitting. | Herein, a WO<sub>3</sub>@TCN photocatalyst was successfully synthesized using a self-assembly method, which demonstrated effectiveness in degrading organic dyestuffs and photocatalytic evolution of H<sub>2</sub>. The synergistic effect between WO<sub>3</sub> and TCN, along with the porous structure of TCN, facilitated ... |
39860244 | Preparation of Colored Polymer Microspheres. | Colored polymer microspheres have attracted significant attention in both academia and industry due to their unique optical properties and extensive application potential. However, achieving a uniform distribution of dyes within these microspheres remains a challenge, particularly when heavy concentrations of dye are u... |
39860242 | Synthesis of an Azido-Substituted 8-Membered Ring Laddersiloxane and Its Application in Catalysis. | A first <i>syn</i>-type tricyclic 8-8-8 (three fused-8-membered ring) laddersiloxane functionalized with four azido groups was successfully synthesized through efficient and highly selective hydrosilylation and nucleophilic substitution, achieving an excellent overall yield. The starting material, a tetravinyl-substitu... |
39860226 | From Molecules to Materials, Devices and Processes: The Chemical Basis of Novel Technologies. | This Special Issue was launched in connection with the joint XIII National Congress of AICIng (the Italian Association of Chemistry for Engineering) and the II National Congress of the Division of Chemistry for the Technologies of the Italian Chemical Society, held at the Politecnico di Milano (Italy) from 25 to 28 Jun... |
39860058 | Epidemiological Characteristics of Hospitalized Burn Patients-A 10-Year Retrospective Study in a Major Burn Center in Serbia. | <h4>Background</h4>Many European countries' epidemiological data on burns were analyzed. This research aimed to analyze the key epidemiological characteristics of hospitalized burn patients in Serbia's major burn unit over 10 years, as well as to create the very first national epidemiological dataset with the basic req... |
39859884 | Structure and Morphological Properties of Cobalt-Oxide-Based (Co<sub>3</sub>O<sub>4</sub>) Materials as Electrodes for Supercapacitors: A Brief Review. | Over the past 15 years, there has been a significant increase in the search for environmentally friendly energy sources, and transition-metal-based energy storage devices are leading the way in these new technologies. Supercapacitors are attractive in this regard due to their superior energy storage capabilities. Elect... |
39859498 | Assessing the Efficacy of Mitochondria-Accumulating Self-Assembly Peptides in Pancreatic Cancer: An Animal Study. | Although pancreatic cancer presents with one of the most unfavorable prognoses, its treatment options are very limited. Mitochondria-targeting moieties, considered a new and prominent treatment modality, are expected to demonstrate synergistic anticancer effects due to their distinct mechanism compared to conventional ... |
39859495 | The Role of microRNA-22 in Metabolism. | microRNA-22 (miR-22) plays a pivotal role in the regulation of metabolic processes and has emerged as a therapeutic target in metabolic disorders, including obesity, type 2 diabetes, and metabolic-associated liver diseases. While miR-22 exhibits context-dependent effects, promoting or inhibiting metabolic pathways depe... |
39859477 | Properties and Applications of Nanoparticles and Nanomaterials. | Nanomaterials have rapidly developed and attention surrounding their use has increased in recent years [...]. |
39859476 | Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds. | Marine polysaccharide hydrogels have emerged as an innovative platform for regulating the in vivo release of natural bioactive compounds for medical purposes. These hydrogels, which have exceptional biocompatibility, biodegradability, and high water absorption capacity, create effective matrices for encapsulating diffe... |
39858961 | Phenotypic Profiling of Selected Cellulolytic Strains to Develop a Crop Residue-Decomposing Bacterial Consortium. | Slow decomposition rates of cereal crop residues can lead to agronomic challenges, such as nutrient immobilization, delayed soil warming, and increased pest pressures. In this regard, microbial inoculation with efficient strains offers a viable and eco-friendly solution to accelerating the decomposition process of crop... |
39858534 | Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs. | Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress has been m... |
39858080 | Deciphering the Blood-Brain Barrier Paradox in Brain Metastasis Development and Therapy. | Gatekeeper or accomplice? That is the paradoxical role of the blood-brain barrier (BBB) in developing brain metastasis (BM). BM occurs when cancerous cells from primary cancer elsewhere in the body gain the ability to metastasize and invade the brain parenchyma despite the formidable defense of the BBB. These metastati... |
39858072 | Calreticulin-From the Endoplasmic Reticulum to the Plasma Membrane-Adventures of a Wandering Protein. | Calreticulin (CRT) is a 46 kDa highly conserved protein initially identified as calregulin, a prominent Ca<sup>2+</sup>-binding protein of the endoplasmic reticulum (ER). Subsequent studies have established that CRT functions in the ER's protein folding response and Ca<sup>2+</sup> homeostatic mechanisms. An ER retenti... |
39856962 | Gellan Gum Enhances the Quality of Egg-Based Yoghurt by Changing the Water Phase Distribution and Improving the Gel Texture. | Egg-based yoghurt (EBY) is a novel yoghurt fermented by lactic acid bacteria with high nutritional and health values, serving as a potential alternative to milk-based yoghurt. However, the hardness, adhesiveness, and water-holding capacity of egg-based yoghurt need to be further improved. In this study, the improvement... |
39856960 | The Effects of Polyphenols on Texture and Flavor of Egg Yolk: A Molecular Docking Study. | The effect of polyphenols on the texture and flavor of egg yolk hot gel (EY) was studied. Tea polyphenols (TP), rosmarinic acid (RE), and curcumin (CC) showed significant antioxidant properties during egg yolk processing and could effectively reduce lipid oxidation products (decreased by 68.9%, 76.4%, and 58.61%, respe... |
39852860 | The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences. | <h4>Background</h4>Polypeptide vaccines have the potential to improve immune responses by targeting conserved and weakly immunogenic regions in antigens. This study aimed to identify and evaluate the efficacy of a novel influenza universal vaccine candidate consisting of multiple polypeptides derived from highly conser... |
39852751 | Facile Synthesis of Functional Mesoporous Organosilica Nanospheres and Adsorption Properties Towards Pb(II) Ions. | We successfully synthesize monodisperse sulfhydryl-modified mesoporous organosilica nanospheres (MONs-SH) via one-step hydrolytic condensation, where cetyltrimethylammonium chloride and dodecyl sulfobetaine are employed as dual-template agents with (3-mercaptopropyl)triethoxysilane and 1,2-bis(triethoxysilyl)ethane as ... |
39852748 | Doxorubicin-Conjugated Nanoparticles for Potential Use as Drug Delivery Systems. | Doxorubicin (DOX) is one of the most widely used chemotherapy drugs in the treatment of both solid and liquid tumors in patients of all age groups. However, it is likely to produce several side effects that include doxorubicin cardiomyopathy. Nanoparticles (NPs) can offer targeted delivery and release of the drug, pote... |
39852274 | Enhancing Virus Filter Performance Through Pretreatment by Membrane Adsorbers. | Virus filtration is used to ensure the high level of virus clearance required in the manufacture of biopharmaceutical products such as monoclonal antibodies. Flux decline during virus filtration can occur due to the formation of reversible aggregates consisting of self-assembled monomeric monoclonal antibody molecules,... |
39848059 | Highly stable lithium metal anodes enabled by bimetallic metal-organic frameworks derivatives-modified carbon cloth. | Lithium (Li) metal anodes hold great promise for next-generation secondary batteries with high energy density. Unfortunately, several problems such as Li dendrite growth, low Coulombic efficiency and poor cycle life hinder the commercialization of Li metal anodes. Herein, we design a highly lithiophilic carbon cloth ho... |
39848018 | β-Sitosterol modulates osteogenic and adipogenic balance in BMSCs to suppress osteoporosis via regulating mTOR-IMP1-Adipoq axis. | <h4>Background</h4>Osteoporosis (OP) is a prevalent global health concern, impacting millions of individuals, especially the elderly. The etiology of senile OP is associated with the imbalance of osteogenic and adipogenic differentiation in the bone marrow mesenchymal stem cells (BMSCs). The imbalance of BMSCs differen... |
39848002 | Sensitivity-enhanced self-powered biosensing platform for detection of sugarcane smut using Mn-doped ZIF-67, RCA-DNA nano-grid array and capacitor. | Sugarcane smut is a widespread fungal disease, which severely impairs the quality and sugar yield of sugarcane. Early detection is crucial for mitigating its impact, which makes the development of a highly sensitive and accurate detection method essential. Herein, the Mn-doped zeolite imidazolate framework (ZIF-67), sy... |
39842312 | Improving synergistic effects within metal-organic framework by modulating structural interpenetration for boosted photocatalytic peroxydisulfate activation. | Metal-organic frameworks (MOFs) have shown significant potential in the photocatalytic activation of peroxydisulfate (PDS). Although many MOFs have been investigated for their ability to activate PDS, the impact of structural interpenetration on this process remains underexplored. In this study, MIL-88D(Fe<sub>2</sub>N... |
39839500 | Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation. | <h4>Background</h4>Dachaihu decoction (DCHD) is a common Chinese medicine formula against sepsis-induced acute lung injury (SALI). PANoptosis is a novel type of programmed cell death. Nevertheless, The mechanisms of DCHD against SALI via anti-PANoptosis remains unknown.<h4>Methods</h4>First, we identified the intersect... |
39834893 | Hydrogen-bonded macrocycle-mediated dimerization for orthogonal supramolecular polymerization. | Orthogonal self-assembly represents a useful methodology to construct supramolecular polymers with AA- and AB-type monomers, as commonly used for covalently linked polymers. So far, the design of such monomers has relied heavily on three-dimensional macrocycles, and the use of two-dimensional shape-persistent macrocycl... |
39833231 | Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite. | The g-C3N4/CS biosensor was designed, fabricated, and tested using compounds such as glucose, urine, lactose, and flutamide at a molarity of 10 µM, which could demonstrate a high sensitivity of 200 μm-1 for flutamide. Powerful effective medium theory and FDTD simulation were used to predict the most favorable mode and ... |
39831043 | Unraveling the structure-property relationships in fluorescent phenylhydrazones: the role of substituents and molecular interactions. | This study investigates the structure-property relationships of a series of phenylhydrazones bearing various electron-donating and electron-withdrawing substituents, such as methoxy, dimethylamino, morpholinyl, hydroxyl, chloro, bromo, and nitro groups. The compounds were synthesized, and their structures were characte... |
39830366 | Recent Advances in Indocyanine Green-Based Probes for Second Near-Infrared Fluorescence Imaging and Therapy. | Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred to as shortwave infrared, has received substantial attention because of its markedly reduced ... |
39829985 | Thiosemicarbazones as versatile photoswitches with light-controllable supramolecular activity. | Using photoswitchable molecules to manipulate supramolecular interactions under light illumination has driven advancements in numerous fields, allowing for the strategic alteration of molecular systems. However, integrating the moiety responsible for these interactions into the photochromic scaffold can be complex and ... |
39828164 | pH-regulated preparation and structural characterization of non-covalent complexes of soybean isolate proteins with different charged polysaccharides. | Soybean protein isolate (SPI) exhibits limited functional properties in processing applications due to environmental stressors such as pH, salt ion, and temperature. The present study was devoted to exploring the non-covalent assembly of SPI with chitosan (CS), glucan (GL) and sodium alginate (SA) under different pH co... |
39827972 | Investigation of flurbiprofen pharmacokinetics in rats following dermal administration of optimized cyclodextrin-based nanogel. | <h4>Purpose</h4>The main purpose of this study was to optimize a cyclodextrin-based nanogel of flurbiprofen (FP) for prolonged dermal administration and evaluate its stability, in vitro release, ex vivo skin permeation, and in vivo pharmacokinetic profile.<h4>Methods</h4>The nanogels were prepared via emulsification/so... |
39827914 | Formulation development and feasibility of AAV5 as a lyophilized drug product. | The majority of adeno-associated virus (AAV) gene therapies are currently developed as frozen formulations (e.g., ≤ - 60 °C) that are challenging to maintain and distribute world-wide. Lyophilization can allow for long-term refrigerated storage and improved shelf-life that lowers long-term cost. Here, we performed a ly... |
39827369 | Determining the rates of α-tocopherol movement in DPPC vesicles using small-angle neutron scattering. | α-tocopherol (αtoc; vitamin E) is an essential nutrient sufficiently acquired through a balanced diet. This fat-soluble vitamin is most known for its antioxidative properties; however, its fundamental mechanism of action in cellular membranes remains unknown. To this end, we use time-resolved small-angle neutron scatte... |
39827003 | Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy. | Tumor-associated macrophages (TAMs) significantly influence the clinical outcomes of immune checkpoint blockade (ICB) therapy. Strategies aimed at reprogramming TAMs from the immunosuppressive M2 phenotype to the pro-inflammatory M1 phenotype hold promise for enhancing ICB efficacy. Lipopolysaccharide (LPS), a potent T... |
39826549 | Structural insights into the role of the proline rich region in tau function. | Tau plays an important role in modulating axonal microtubules in neurons, while intracellular tau aggregates are found in many neurodegenerative disorders. Tubulin binding sites are found in tau's proline-rich region (PRR), microtubule binding repeats (MTBRs), and pseudo-repeat (R'). Tau phosphorylation sites, which cl... |
39826356 | A novel supramolecular nanodrugs for improving the cognitive function of schizophrenia by protecting active lactone of arecoline. | Over 30 % of patients with schizophrenia experience treatment resistance and severe side effects. The limited efficacy of antipsychotic therapies poses a challenge, partly due to the blood-brain barrier (BBB) and the non-selective targeting of these drugs. Herein, we report on arecoline (ARE), a water soluble natural s... |
39825429 | The role of laminins in cancer pathobiology: a comprehensive review. | Laminins (LMs) are a family of heterotrimeric glycoproteins that form the structural foundation of basement membranes (BM). By acting as molecular bridges between cells and the extracellular matrix (ECM) through integrins and other surface receptors, they regulate key cellular signals that influence cell behavior and t... |
39825382 | V-ATPase in glioma stem cells: a novel metabolic vulnerability. | <h4>Background</h4>Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity. Here we studied how patients-derived GSCs rely on V-ATPase activity to sustain mitochondrial bi... |
39825014 | Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia. | Schizophrenia is a chronic and severe mental disorder. It is currently treated with antipsychotic drugs (APD). However, APD's work only in a limited number of patients and may have cognition impairing side effects. A growing body of evidence points out the potential involvement of abnormal sphingolipid metabolism in th... |
39825012 | Challenges and opportunities for digital twins in precision medicine from a complex systems perspective. | Digital twins (DTs) in precision medicine are increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. We argue that including mechanistic simulations that produce behavior based on explicitly defined biological hypothe... |
39825002 | Cannabidiol and Hydroxypropyl-β-Cyclodextrin for the Development of Deflated Spherical-Shaped Inhalable Powder. | In addition to the known therapeutic indications for cannabidiol, its administration by inhalation appears to be of great interest. Indeed, there is evidence of cannabidiol's efficacy in several physiological pathways, suggesting its potential for a wide range of applications for both local and systemic pulmonary admin... |
39824927 | Norovirus replication, host interactions and vaccine advances. | Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide in all age groups and cause significant disease and economic burden globally. To date, no approved vaccines or antiviral therapies are available to treat or prevent HuNoV illness. Several candidate vaccines are in clinical trials, altho... |
39824828 | Metal-organic cage crosslinked nanocomposites with enhanced high-temperature capacitive energy storage performance. | Polymer dielectric materials are widely used in electrical and electronic systems, and there have been increasing demands on their dielectric properties at high temperatures. Incorporating inorganic nanoparticles into polymers is an effective approach to improving their dielectric properties. However, the agglomeration... |
39824822 | Dynamic hydrogen-bonding enables high-performance and mechanically robust organic solar cells processed with non-halogenated solvent. | Developing active-layer systems with both high performance and mechanical robustness is a crucial step towards achieving future commercialization of flexible and stretchable organic solar cells (OSCs). Herein, we design and synthesize a series of acceptors BTA-C6, BTA-E3, BTA-E6, and BTA-E9, featuring the side chains o... |
39824813 | Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin. | Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington's disease (HD). Since no current treatment delays the progression of HD, we develop a mechanistic approach to prevent mutant huntingtin (mHttex1) aggregation. Here, we engineer the ATP-independent cytosolic chaperone P... |
39824777 | Investigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging. | Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by histological examination, clinical pathology, and the detection of drugs and/or metabolites by liquid c... |
39824751 | Three-Dimensional SERS-Active Hydrogel Microbeads Enable Highly Sensitive Homogeneous Phase Detection of Alkaline Phosphatase in Biosystems. | Alkaline phosphatase (ALP) is a biomarker for many diseases, and monitoring its activity level is important for disease diagnosis and treatment. In this study, we used the microdroplet technology combined with an <i>in situ</i> laser-induced polymerization method to prepare the Ag nanoparticle (AgNP) doped hydrogel mic... |
39824609 | Bioinspired Assembly of Natural Polyphenol-Amino Acid Surfactants as Multifunctional Durable Coatings for Anticorrosion Fruit Packaging. | Challenges emerge in the quest for highly efficient and biocompatible coatings to tackle microbial contamination. Here, we propose a bioinspired paradigm combining (-)-epigallocatechin gallate (EGCG) and l-arginine surfactants (LAM) as all-green building blocks for advanced coatings with superior performance. Molecular... |
39824101 | Molecular foundations for shear-induced dynamics of natural organic matter. | The overall objective of the present work was to quantify how shear, coupled with varying salt concentration, affected the particle size distribution and relaxation/aggregation behavior for various organic sources of nonliving natural organic matter (NNOM) in surface water. NNOM has been implicated as a conditioning ag... |
39823563 | Guest Segregation in Heteromeric Multicage Systems. | Dynamically interconvertible metallo-supramolecular multicomponent assemblies, coexisting orthogonally in solution, serve as simplified mimics for complex networks found in biological systems. Building on recent advances in controlling the nonstatistical self-assembly of heteroleptic coordination cages and heteromeric ... |
39823544 | Computational Insights into Membrane Disruption by Cell-Penetrating Peptides. | Cell-penetrating peptides (CPPs) can translocate into cells without inducing cytotoxicity. The internalization process implies several steps at different time scales ranging from microseconds to minutes. We combine adaptive Steered Molecular Dynamics (aSMD) with conventional Molecular Dynamics (cMD) to observe nonequil... |
39823526 | Unveiling the Werner-Type Cluster Chemistry of Heterometallic 4f/Post-Transition Metals: A {Dy<sub>3</sub>Bi<sub>8</sub>} Complex Exhibiting Quantum Tunneling Steps in the Hysteresis Loops and its 1-D Congener. | A new [Dy<sub>3</sub>Bi<sub>8</sub>O<sub>6</sub>Cl<sub>3</sub>(saph)<sub>9</sub>] (<b>1</b>) Werner-type cluster has been prepared, which is the first Dy<sup>III</sup>/Bi<sup>III</sup> polynuclear compound with no metal-metal bond and one of the very few Ln<sup>III</sup>-Bi<sup>III</sup> (Ln = lanthanide) heterometalli... |
39823459 | Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress-Associated Degradation of EZH2/MYC Axis. | Despite substantial advances in the antitumor effects of annonaceous acetogenins (ACGs), the absence of a defined biological action mechanism remains a major barrier to their clinical application. Here, it is found that squamocin effectively depletes both EZH2 and MYC in multiple cancer cell lines, including head and n... |
39823416 | H-Dots: Renal Clearable Zwitterionic Nanocarriers for Disease Diagnosis and Therapy. | Nanocarriers have shown significant promise in the diagnosis and treatment of various diseases, utilizing a wide range of biocompatible materials such as metals, inorganic substances, and organic components. Despite diverse design strategies, key physicochemical properties, including hydrodynamic diameter, shape, surfa... |
39823413 | Nb-FAR-1: A key developmental protein affects lipid droplet accumulation and cuticle formation in Nippostrongylus brasiliensis. | Fatty acid and retinol binding proteins (FARs) are lipid-binding protein that may be associated with modulating nematode pathogenicity to their hosts. However, the functional mechanism of FARs remains elusive. We attempt to study the function of a certain FAR that may be important in the development of Nippostrongylus ... |
39823391 | Evidence for Endogenous Collagen in <i>Edmontosaurus</i> Fossil Bone. | Reports of proteins in fossilized bones have been a subject of controversy in the scientific literature because it is assumed that fossilization results in the destruction of all organic components. In this paper, a novel combination of analytical techniques is used to address this question for an exceptionally well-pr... |
39823343 | Oral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system. | Acute alcohol intoxication could cause multiorgan damage, including nervous, digestive, and cardiovascular systems, and in particular, irreversible damage to the brain and liver. Emerging studies have revealed that the endogenous multienzymatic antioxidant defense system (MEAODS) plays a central role in preventing oxid... |
39823334 | Programmed shape transformations in cell-laden granular composites. | Tissues form during development through mechanical compaction of their extracellular matrix (ECM) and shape morphing, processes that result in complex-shaped structures that contribute to tissue function. While observed in vivo, control over these processes in vitro to understand both tissue development and guide tissu... |
39823333 | Biomimetic wrinkled prebiotic microspheres with enhanced intestinal retention for hyperphosphatemia and vascular calcification. | It is urgent for patients with chronic kidney disease (CKD) to develop a robust and facile therapy for effective control of serum phosphate and reasonable regulation of gut microbiota, which are aiming to prevent cardiovascular calcification and reduce cardiovascular complications. Here, bioinspired by intestinal micro... |
39823328 | Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma. | The prevalent tumor-supporting glioblastoma-associated macrophages (GAMs) promote glioblastoma multiforme (GBM) progression and resistance to multiple therapies. Repolarizing GAMs from tumor-supporting to tumor-inhibiting phenotype may troubleshoot. However, sufficient accumulation of drugs at the GBM site is restricte... |
39823312 | Strain-Induced Photochemical Opening of Ferrocene[6]cycloparaphenylene: Uncaging of Fe<sup>2+</sup> with Green Light. | We present the synthesis, structural analysis, and remarkable reactivity of the first carbon nanohoop that fully incorporates ferrocene in the macrocyclic backbone. The high strain imposed on the ferrocene by the curved nanohoop structure enables unprecedented photochemical reactivity of this otherwise photochemically ... |
39823274 | Nitrogen-Rich Barium-Organic Framework for Capture and Cocatalysts Free Chemical Fixation of CO<sub>2</sub> via Cyclic Carbonates and Oxazolidinones. | The carbon dioxide (CO<sub>2</sub>) capture and utilization strategy has emerged as an innovative and multifaceted approach to counteract carbon emissions. In this study, a highly porous muffin polyhedral barium (Ba) ̵ organic framework (BaTATB; H<sub>3</sub>TATB = 4,4',4″-<i>s</i>-triazine-2,4,6-triyl-tribenzoic acid)... |
39823271 | Chirality Interplay of Peptide and Saccharide on Glycopeptide Self-Assembly. | Saccharides and peptides with markedly disparate stereochemical features serve as pivotal chiral molecular partners in living systems. The importance of glycosylation in influencing glycopeptide self-assembly has been recognized. However, how different chiral combinations of saccharides and peptides influence the macro... |
39823225 | Breath Analysis via Surface Enhanced Raman Spectroscopy. | Breath analysis is increasingly recognized as a powerful noninvasive diagnostic technique, and a plethora of exhaled volatile biomarkers have been associated with various diseases. However, traditional analytical methodologies are not amenable to high-throughput diagnostic applications at the point of need. An optical ... |
39823199 | Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery. | Since their inception in the early 1960s, the development and use of nanoscale materials have progressed tremendously, and their roles in diverse fields ranging from human health to energy and electronics are undeniable. The application of nanotechnology inventions has revolutionized many aspects of everyday life inclu... |
39821590 | Covalent Affibody-Molecular Glue Drug Conjugate Nanoagent for Proximity-Enabled Reactive Therapeutics. | Sulfur-fluoride exchange (SuFEx) reaction is an emerging class of click chemistry reaction. Owing to its efficient reactivity under physiological conditions, SuFEx reaction is used to construct covalent protein drugs. Herein, a covalent affibody-molecular glue drug conjugate nanoagent is reported, which can irreversibl... |
39821345 | In silico functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires. | T cells recognize peptides displayed on the surface of cells on MHC molecules. Genetic variation in MHC genes alters their peptide-binding repertoire and thus influences the potential immune response generated against pathogens. Both gorillas and chimpanzees show reduced diversity at their MHC class I A (MHC-A) locus c... |
39821344 | Beyond Tradition: A MOF-On-MOF Cascade Z-Scheme Heterostructure for Augmented CO<sub>2</sub> Photoreduction. | Metal-organic frameworks (MOFs) are rigorously investigated as promising candidates for CO<sub>2</sub> capture and conversion. MOF-on-MOF heterostructures integrate bolstered charger carrier separation with the intrinsic advantages of MOF components, exhibiting immense potential to substantially escalate the efficiency... |
39821341 | The continuing significance of chiral agrochemicals. | Chemical crop protection is one of the most cost-effective methods for agriculture, as crop failures can be prevented, and sustainable growth can be enabled regardless of the seasons. Agricultural production must be significantly increased in the future to meet the food needs of a growing world population. However, the... |
39820322 | Cigarette smoke components modulate the MR1-MAIT axis. | Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function. MR1 is a ubiquitous molecule that presents bacterial metabolites to MAIT cells, which are highly abundant in the lungs. Using in... |
39820045 | Adaptive evolution of SARS-CoV-2 during a persistent infection for 521 days in an immunocompromised patient. | Immunocompromised patients struggle to adequately clear viral infections, offering the virus the opportunity to adapt to the immune system in the host. Here we present a case study of a patient undergoing allogeneic hematopoietic stem cell transplantation with a 521-day follow-up of a SARS-CoV-2 infection with the BF.7... |
39819733 | S-layers: from a serendipitous discovery to a toolkit for nanobiotechnology. | Prokaryotic microorganisms, comprising <i>Bacteria</i> and <i>Archaea</i>, exhibit a fascinating diversity of cell envelope structures reflecting their adaptations that contribute to their resilience and survival in diverse environments. Among these adaptations, surface layers (S-layers) composed of monomolecular prote... |
39818973 | Dual-Stage Stacking Machine Learning Method Considering Virtual Sample Generation for the Prediction of ZIF-8' BET Specific Surface Area with Experimental Validation. | The widespread application of metal-organic frameworks (MOFs) in wastewater and gas treatment has created an increasing demand for accurate and rapid assessment of their BET specific surface area. However, experimental methods for acquiring sufficient statistical data are often costly and time-consuming. Therefore, thi... |
39818949 | Ab Initio Predictions of Adsorption in Flexible Metal-Organic Frameworks for Water Harvesting Applications. | Metal-organic frameworks such as MOF-303 and MOF-LA2-1 have demonstrated exceptional performance for water harvesting applications. To enable a reticular design of such materials, an accurate prediction of the adsorption properties with chemical accuracy and fully accounting for the flexibility is crucial. The computat... |
39818939 | Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2<i>H</i>-pyrrol-2-yl)phosphonates as Imidazoline <i>I</i><sub>2</sub> Receptor Ligands with Anti-Alzheimer and Analgesic Properties. | Imidazoline <i>I</i><sub>2</sub> receptors (I<sub>2</sub>-IRs) are altered in Alzheimer's disease (AD) patients and are associated with analgesia. I<sub>2</sub>-IRs are not structurally described, and their pharmacological characterization relies on their modulation by highly affine ligands. Herein, we describe the syn... |
39818874 | Mapping <i>C. difficile</i> TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling. | Many bacterial toxins exert their cytotoxic effects by enzymatically inactivating one or more cytosolic targets in host cells. To reach their intracellular targets, these toxins possess functional domains or subdomains that interact with and exploit various host factors and biological processes. Despite great progress ... |
39818834 | NesT-NABind: a Nested Transformer for Nucleic Acid-Binding Site Prediction on Protein Surface. | Protein-nucleic acid interactions play a crucial role in many physiological processes. Identifying the binding sites of nucleotides on the protein surface is the prerequisite for understanding the molecular recognition mechanisms between the two types of macromolecules and also provides the information to design or gen... |
39818785 | An Integral-Direct GOSTSHYP Algorithm for the Computation of High Pressure Effects on Molecular and Electronic Structure. | To simulate the effects of high pressure on molecular and electronic structure, methods based on the polarizable continuum model have emerged as a serious contender to the conventionally employed periodic boundary conditions. In this work, we present a highly efficient integral-direct algorithm for the Gaussians On Sur... |
39818769 | Substituent and Heteroatom Effects on π-π Interactions: Evidence That Parallel-Displaced π-Stacking is Not Driven by Quadrupolar Electrostatics. | Stacking interactions are a recurring motif in supramolecular chemistry and biochemistry, where a persistent theme is a preference for parallel-displaced aromatic rings rather than face-to-face π-stacking. This is typically explained in terms of quadrupole-quadrupole interactions between the arene moieties but that int... |
39818743 | Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics. | The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key limitation to the broad application of TPD is its dependence on small-molecule ligands to target proteins of interest. This leaves uns... |
39818739 | Advancements and Prospects in Nanorobotic Applications for Ophthalmic Therapy. | This study provides a bibliometric and bibliographic review of emerging applications of micro- and nanotechnology in treating ocular diseases, with a primary focus on glaucoma. We aim to identify key research trends and analyze advancements in devices and drug delivery systems for ocular treatments. The methodology inv... |
39818700 | Reactivity of Olanzapine and Tricyclic Antidepressants on the Protective Effects of Trolox on Lipid Peroxidation Evaluated Using Fluorescence Anisotropy, Electron Paramagnetic Resonance Spectrometry, and Thermal Analysis. | Multiacting receptor-targeting antipsychotics and tricyclic antidepressants stimulate various neurotransmitter receptors despite the different targets of postsynaptic receptors and presynaptic reuptake transporters. Their auxiliary and adverse effects may be caused by multiple targets or the modification of the neurona... |
39791355 | A Malleable Collagen-Mimic that Undergoes Moisture-Induced Hardening for Gluing Hydrophilic Surfaces. | A collagen-inspired helical protein-mimic has been synthesized via topochemical polymerization of a designed tripeptide monomer. In the monomer crystal, molecules arrange in a head-to-tail manner, forming supramolecular helices. The azide and alkyne of adjacent molecules in the supramolecular helix are proximally preor... |
39777849 | Orderly Arranged Cubic Quantum Dots along Supramolecular Templates of Naphthalenediimide Aggregates. | Precise control of assembled structures of quantum dots (QDs) is crucial for realizing the desired photophysical properties, but this remains challenging. Especially, the one-dimensional (1D) control is rare due to the nearly isotropic nature of QDs. Herein, we propose a novel strategy for controlling the 1D-arrangemen... |
39745193 | Advanced Alkali Metal Batteries Based on MOFs and Their Composites. | The integration of metal-organic frameworks (MOFs) with functional materials has established a versatile platform for a wide range of energy storage applications. Due to their large specific surface area, high porosity, and tunable structural properties, MOFs hold significant promise as components in energy storage sys... |
39358003 | Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism. | <h4>Background</h4>The microbiota is emerging as a key factor in the predisposition to insulin resistance and obesity.<h4>Objective</h4>To understand the interplay among gut microbiota and insulin sensitivity in multiple tissues.<h4>Design</h4>Integrative multiomics and multitissue approach across six studies, combinin... |
40395752 | Synthetic Biology-Based Engineering Cells for Drug Delivery. | Although drug delivery technology has promoted the clinical translation of small molecule drugs, there is an urgent need for advanced delivery systems to overcome complex physiological barriers and the increasing development of biological drugs. This review overviews the emerging applications of synthetic biology-based... |
40074431 | Unveiling the molecular activity of HIV towards the CD4: A study based on subtype C via docking and dynamics approach. | <h4>Background</h4>Acquired Immunodeficiency Syndrome (AIDS) is a critical global health issue caused by the human immunodeficiency virus (HIV). It has different strains and subtypes; among these, Subtype C accounts for higher infection rates than others. Despite its high prevalence, the molecular interactions with hos... |
39984204 | Ultrasensitive detection of Vibrio parahaemolyticus based on boric acid-functionalized Eu (III)-based metal-organic framework. | This study intends to create a ratiometric fluorescence probe utilizing aptamers for the detection of Vibrio parahaemolyticus (V. parahaemolyticus) in aquatic products. In this design, aptamer-functionalized magnetic nanoparticles specifically capture V. parahaemolyticus, while boric acid on Eu (III)-Based Metal-Organi... |
39919856 | A ratiometric electrochemical aptasensor for Ochratoxin A detection based on electroactive Cu-MOF and DNA conjugates resembling the structure of Bidens pilosa. | <h4>Background</h4>Ochratoxin A (OTA) represents a naturally occurring mycotoxin with a serious hazard to the health of individuals because of carcinogenic and teratogenic properties. To date, various analytical methods have been developed for the detection of OTA, among which aptamer-based electrochemical sensing has ... |
39914984 | Unveiling the suitability of C-starch as functional food: A pairwise interaction of lipids and polyphenol components (LIPOP). | C-starch is distinguished by its unique crystalline structure, combining A-type and B-type polymorphs, primarily into C<sub>A</sub> and C<sub>B</sub> configurations. This hybrid structure imparts C-starch with intermediate physicochemical and functional properties, bridging the characteristics of purely A-type and B-ty... |
39911354 | Effects of synergistic fermentation of tea bee pollen with bacteria and enzymes on growth and intestinal health of <i>Apis cerana cerana</i>. | While the health benefits of lactic acid bacteria (LAB)-fermented feed on farmed animals are well-established, its potential benefits for honeybees, specifically <i>Apis cerana cerana</i>, remain largely unexplored. The present study aimed to optimize an enzymatic hydrolysis process for tea bee pollen, employing a comp... |
39906852 | Deciphering the potential of plant metabolites as insecticides against melon fly (<i>Zeugodacus cucurbitae</i>): Exposing control alternatives to assure food security. | In the absence of effective biological or chemical controls, the melon fly poses a significant threat to food security, particularly impacting cucurbit crops in tropical and subtropical regions. Melon fly infestations have resulted in yield losses of 30 %-100 %, depending on the specific cucurbit species and season. Cu... |
39895741 | Syntheses and Structures of Functionalized Macrocyclic Carbon Nanohoops Bearing a [9]Cycloparaphenylene or a Higher Homological Unit. | The Diels-Alder reactions between (<i>E</i>,<i>E</i>)-1,4-bis(4-bromophenyl)-1,3-butadiene and dienophiles and the use of the resulting adducts for macrocyclization and aromatization were established. Several functionalized macrocyclic structures bearing a functionalized [9]cycloparaphenylene or a higher homological un... |
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