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39895739 | High-Sensitivity NO<sub>2</sub> Gas Sensor: Exploiting UV-Enhanced Recovery in a Hexadecafluorinated Iron Phthalocyanine-Reduced Graphene Oxide. | Monitoring ultralow nitrogen dioxide (NO<sub>2</sub>) concentrations is crucial for air quality management and public health. However, the existing NO<sub>2</sub> gas sensors have several defects, like high cost and power consumption, and exhibit poor selectivity. This study addresses these challenges by presenting a n... |
39895735 | Sustainable Active Packaging from On-Demand Degradable PLA/PBAT and Zn-Doped TiO<sub>2</sub> Composites. | Shelf life extendable packaging and ethylene scavenger technologies for climacteric fruits and vegetables have garnered much attention in recent years. These products effectively enable food quality to be maintained, ensure food safety, and prolong food storage life, which are key to helping reduce food waste. Current ... |
39895732 | Application of Solid-Supported Amines for Thermocatalytic Reactive CO<sub>2</sub> Capture. | Reactive CO<sub>2</sub> capture (RCC) is a promising strategy for process intensification of carbon capture and conversion for production of low-carbon fuels and chemicals. As state-of-the-art sorbent materials in point source and direct air capture systems, solid-supported amines are a natural choice to pair with supp... |
39895710 | Metal-Dilution Effect on Spin Transition Behavior of Solvated/Desolvated Hydrogen-Bonded Cobalt(II)-Organic Frameworks. | Terpyridine-based cobalt(II) complex, [Co<sup>II</sup>(HL)<sub>2</sub>] (<b>1</b>; H<sub>2</sub>L = 2,2':6',2″-terpyridine-5,5″-diyl dicarboxylic acid), forms a hydrogen-bonded diamond framework with solvent absorption and desorption capabilities. The desolvated form (<b>1</b>·desolv) exhibits spin transition (ST) beha... |
39886688 | Analysis of stomatal characteristics of maize hybrids and their parental inbred lines during critical reproductive periods. | The stomatal phenotype is a crucial microscopic characteristic of the leaf surface, and modulating the stomata of maize leaves can enhance photosynthetic carbon assimilation and water use efficiency, thereby playing a vital role in maize yield formation. The evolving imaging and image processing technologies offer effe... |
39886558 | Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations. | Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections represent critical global health challenges due to the high morbidity and mortality associated with co-infections. HIV, the causative agent of acquired immunodeficiency syndrome (AIDS), infects 4,000 people daily, potentially leading to 1.2 milli... |
39886476 | Green Synthesis of Cellulose Acetate Mixed Matrix Membranes: Structure-Function Characterization. | Although membrane technology is widely used in different gas separation applications, membrane manufacturers need to reduce the environmental impact during the membrane fabrication process within the framework of the circular economy by replacing toxic solvents, oil-based polymers, and such by more sustainable alternat... |
39885844 | Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against <i>Rickettsia felis</i> using integrated computational approaches. | <i>Rickettsia felis</i>, responsible for flea-borne spotted fever, is a rising zoonotic pathogen posing an increasing global threat due to its expanding geographical distribution. The rise in antibiotic-resistant strains of this pathogen underscores the urgent need for new therapeutic interventions. This study employed... |
39866233 | Melanoma-derived extracellular vesicles transfer proangiogenic factors. | Angiogenesis, the expansion of pre-existing vascular networks, is crucial for normal organ growth and tissue repair, but is also involved in various pathologies, including inflammation, ischemia, diabetes, and cancer. In solid tumors, angiogenesis supports growth, nutrient delivery, waste removal, and metastasis. Tumor... |
39862848 | Modulation of interface structure on titanium-based metal-organic frameworks heterojunctions for boosting photocatalytic carbon dioxide reduction. | Rational regulation of interface structure in photocatalysts is a promising strategy to improve the photocatalytic performance of carbon dioxide (CO<sub>2</sub>) reduction. However, it remains a challenge to modulate the interface structure of multi-component heterojunctions. Herein, a strategy integrating heterojuncti... |
39861906 | Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses. | Lassa fever (LF), a viral hemorrhagic fever disease with a case fatality rate that can be over 20% among hospitalized LF patients, is endemic to many West African countries. Currently, no vaccines or therapies are specifically licensed to prevent or treat LF, hence the significance of developing therapeutics against th... |
39861905 | Enhanced Immunogenicity and Affinity with A35R-Fc-Based Chimeric Protein Compared to MPXV A35R Protein. | The re-emergence of the mpox pandemic poses considerable challenges to human health and societal development. There is an urgent need for effective prevention and treatment strategies against the mpox virus (MPXV). In this study, we focused on the A35R protein and created a chimeric A35R-Fc protein by fusing the Fc reg... |
39861907 | Gene Therapy for Glioblastoma Multiforme. | Glioblastoma multiforme (GBM) is a devastating, aggressive primary brain tumor with poor patient outcomes and a five-year survival of less than 10%. Significant limitations to effective GBM treatment include poor drug delivery across the blood-brain barrier, drug resistance, and complex genetic tumor alterations. Gene ... |
39861768 | Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment. | In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the... |
39861291 | Improving Sensitivity and Resolution of Dendrimer Identification in MALDI-TOF Mass Spectrometry Using Varied Matrix Combinations. | Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a well-known technique for polymer analysis, particularly for determining the molecular weight and structural details of dendrimers. In this study, we evaluated the performance of various matrices, such as 2',4',6'-trihydroxy... |
39860219 | Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 M<sup>pro</sup>. | The three-year COVID-19 pandemic 'has' caused a wide range of medical, social, political, and financial implications. Since the end of 2020, various mutations and variations in SARS-CoV-2 strains, along with the immune escape phenomenon, have emerged. There is an urgent need to identify a relatively stable target for t... |
39859456 | Study on the Effect of Bee Venom and Its Main Component Melittin in Delaying Skin Aging in Mice. | Bee venom (BV) and its main compound melittin (MLT) have antioxidant, anti-inflammatory, and anti-aging activities; however, very little research has been conducted on their effects on skin aging. In this study, a mouse skin aging model induced by D-galactose was constructed via subcutaneous injection into the scruff o... |
39859434 | Strategies for Survival of <i>Staphylococcus aureus</i> in Host Cells. | <i>Staphylococcus aureus</i>, a common pathogen, is capable of producing a significant array of toxins and can develop biofilms or small colony variants (SCVs) to evade detection by the immune system and resist the effects of antibiotics. Its ability to persist for extended periods within host cells has led to increase... |
39859427 | Easy One-Pot Decoration of Graphene Oxide Nanosheets by Green Silver Nanoparticles. | In this study, we developed a facile one-pot synthesis of a nanocomposite consisting of silver nanoparticles (AgNPs) growing over graphene oxide (GO) nanoflakes (AgNPs@GO). The process consists of the in situ formation of AgNPs in the presence of GO nanosheets via the spontaneous decomposition of silver(I) acetylaceton... |
39856949 | Assessment of Protein Quality and Nutritional Characteristics of Commonly Consumed Pulses in the Caribbean Diet by Different In Vitro Assays. | Pulses, the dried seeds of leguminous plants, form an important part of the diets of many cultures, including Caribbean cuisine, and are a rich source of protein, carbohydrates, and antioxidants while being low in fats. This study examined the effect of a traditional home-cooking method on the nutritional characteristi... |
39855083 | Quantification of solvation forces with amplitude modulation AFM. | <h4>Hypothesis</h4>Interfacial solvation forces arise from the organisation of liquid molecules near solid surfaces. They are crucial to fundamental phenomena, spanning materials science, molecular biology, and technological applications, yet their molecular details remain poorly understood. Achieving a complete unders... |
39852941 | Efficacy of Chlorogenic Acid in Treating Tripterygium Glycoside-Induced Asthenozoospermia in Rats and Its Possible Mechanisms. | Tripterygium glycosides (TGs) are the most common form of traditional Chinese medicine, known as Tripterygium wilfordii Hook F (TWHF) [...]. |
39852858 | Inactivation of Zika Virus with Hydroxypropyl-Beta-Cyclodextrin. | <b>Background/Objectives</b>: Zika virus (ZIKV) infection is associated with life-threatening diseases in humans. To date, there are no available FDA-approved therapies or vaccines for the specific treatment or prevention of ZIKV infection. Variation in the ZIKV envelope protein (Env), along with its complex quaternary... |
39852743 | Mesoporous Nitrogen-Doped Carbon Support from ZIF-8 for Pt Catalysts in Oxygen Reduction Reaction. | Zeolitic imidazolate framework-8 (ZIF-8) has been extensively studied as a precursor for nitrogen-doped carbon (NC) materials due to its high surface area, tunable porosity, and adjustable nitrogen content. However, the intrinsic microporous structure of the ZIF-8 limits mass transport and accessibility of reactants to... |
39852740 | Chitosan and Its Nanoparticles: A Multifaceted Approach to Antibacterial Applications. | Chitosan, a multifaceted amino polysaccharide biopolymer derived from chitin, has extensive antibacterial efficacy against diverse pathogenic microorganisms, including both Gram-negative and Gram-positive bacteria, in addition to fungi. Over the course of the last several decades, chitosan nanoparticles (NPs), which ar... |
39852738 | Temperature Sensing in Agarose/Silk Fibroin Translucent Hydrogels: Preparation of an Environment for Long-Term Observation. | Environmental changes, such as applied medication, nutrient depletion, and accumulation of metabolic residues, affect cell culture activity. The combination of these factors reflects on the local temperature distribution and local oxygen concentration towards the cell culture scaffold. However, determining the temporal... |
39852737 | Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment. | Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging the unique advantages of nanotechnology to enhance the effectiveness and specificity of cancer treatments. These vaccines utilize nanoscale carriers to deliver tumor-associated antigens and immunostimulatory adj... |
39852676 | The Global Challenge of <i>Campylobacter</i>: Antimicrobial Resistance and Emerging Intervention Strategies. | Antimicrobial resistance (AMR) in <i>Campylobacter</i> species, particularly <i>C. jejuni</i> and <i>C. coli</i>, poses a significant public health threat. These bacteria, which are commonly found in livestock, poultry, companion animals, and wildlife, are the leading causes of foodborne illnesses, often transmitted th... |
39852584 | Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances. | The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field of regenerative medicine. This paper aims to provide a comprehensive overview of 3D printing/bioprinting technology and cell therapies, highlighting their... |
39852175 | Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker. | Ferritin is found in all cells of the body, serving as a reservoir of iron and protecting against damage to the molecules that make up cellular structures. It has emerged as a biomarker not only for iron-related disorders but also for inflammatory diseases and conditions in which inflammation plays a key role, includin... |
39852107 | MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient's Blood at Three Years Follow-Up, and Gender Correlation. | Colorectal cancer represents 10% of all the annual tumors diagnosed worldwide, being often not timely diagnosed, because its symptoms are typically lacking or very mild. Therefore, it is crucial to develop and validate innovative low-invasive techniques to detect it before becoming intractable. To this aim, a device eq... |
39852043 | Environmental and Wastewater Treatment Applications of Stimulus-Responsive Hydrogels. | Stimulus-responsive hydrogels have emerged as versatile materials for environmental and wastewater treatment applications due to their ability to adapt to changing environmental conditions. This review highlights recent advances in the design, synthesis, and functionalization of such hydrogels, focusing on their enviro... |
39852042 | Development of Thermoresponsive Composite Hydrogel Loaded with Indocyanine Green and Camptothecin for Photochemotherapy of Skin Cancer After Surgery. | Skin cancer is the world's fifth most diagnosed malignancy and is increasingly occurring in young adults. The elevated morbidity and mortality of skin cancer are known to be highly correlated with its frequent recurrence after tumor excision. Although regimens such as chemotherapy and/or immunotherapy are often adminis... |
39852041 | Characteristics and Functional Properties of Bioactive Oleogels: A Current Review. | Oleogels have been a revolutionary innovation in food science in terms of their health benefits and unique structural properties. They provide a healthier alternative to traditional solid or animal fats. They have improved oxidative stability and nutritional value to maintain the desirable sensory qualities of lipid-ba... |
39851774 | Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides. | Under benign conditions, bone tissue can regenerate itself without external intervention. However, this regenerative capacity can be compromised by various factors, most importantly related with the extent of the injury. Critical-sized defects, exceeding the body's natural healing ability, demand the use of temporary o... |
39846614 | Phenomenological Modeling of Antibody Response from Vaccine Strain Composition. | The elicitation of broadly neutralizing antibodies (bnAbs) is a major goal of vaccine design for highly mutable pathogens, such as influenza, HIV, and coronavirus. Although many rational vaccine design strategies for eliciting bnAbs have been devised, their efficacies need to be evaluated in preclinical animal models a... |
39846525 | <i>ABCB1</i> Polymorphism Is Associated with Higher Carbamazepine Clearance in Children. | The aim of our study was to investigate the role of <i>ABCB1</i> polymorphism in the pharmacokinetics of carbamazepine (CBZ) in children. The study enrolled 47 Serbian pediatric epileptic patients on CBZ treatment. Genotyping for <i>ABCB1</i> 1236C<T (rs1128503), 2677G<A/T (rs2032582) and 3435C<T (rs1045642) was carrie... |
39845335 | Efficacy and Safety of Antimalarial as Repurposing Drug for COVID-19 Following Retraction of Chloroquine and Hydroxychloroquine. | Various repurposing drugs have been tested for their efficacy on coronavirus disease 2019 (COVID-19), including antimalarial drugs. During the pandemic, Chloroquine (CQ) and Hydroxychloroquine (HCQ) demonstrated good potential against COVID-19, but further studies showed both drugs had side effects that were more dange... |
39839457 | Application of Multifunctional Metal Nanoparticles in the Treatment of Glioma. | Glioma is the most common primary malignant brain tumor with a poor survival rate. It is characterized by diffuse and invasive growth and heterogeneity, which limits tumor identification and complete resection. Therefore, the precise detection and postoperative adjuvant therapy of gliomas have become increasingly impor... |
39835181 | Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2. | <h4>Purpose</h4>Outer membrane vesicles (OMVs) derived from Gram-negative bacteria naturally serve as a heterologous nano-engineering platform, functioning as effective multi-use nanovesicles for diagnostics, vaccines, and treatments against pathogens. To apply refined OMVs for human theranostic applications, we develo... |
39831267 | Antiangiogenic potential of <i>Elaeagnus umbellata</i> extracts and molecular docking study by targeting VEGFR-2 pathway. | <h4>Background</h4>Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. Natural sources like plants are currently being explored for its antiangiogenic activity as they are factories of various phytochemicals. The goal of the current study is to inves... |
39829974 | From 0D to 2D: microwave-assisted synthesis of electrically conductive metal-organic frameworks with controlled morphologies. | Morphology control of electrically conductive metal-organic frameworks (EC-MOFs) can be a powerful means to tune their surface area and carrier transport pathways, particularly beneficial for energy conversion and storage. However, controlling EC-MOFs' morphology is underexplored due to the uncontrollable crystal nucle... |
39826811 | Rapid, flexible fabrication of a microfluidic electrochemical chip nucleic acid target for selective, label-free detection of influenza virus DNA using catalytic redox-recycling. | H5N1 flu is a highly virulent and variable subtype of influenza with significant epidemic and pandemic potential. In this study, we introduce a novel, maskless, and rapid manufacturing process for a microfluidic chip integrated with electrodes for the quantitative detection of H5N1-DNA sequences. This detection leverag... |
39826709 | Chaperone-Mediated Heterotypic Phase Separation Prevents the Amyloid Formation of the Pathological Y145Stop Prion Protein Variant. | Biomolecular condensates formed via phase separation of proteins and nucleic acids are crucial for the spatiotemporal regulation of a diverse array of essential cellular functions and the maintenance of cellular homeostasis. However, aberrant liquid-to-solid phase transitions of such condensates are associated with sev... |
39826689 | P300/RNA polymerase II mediates induction of the teleost viral RNA sensor MDA5 through the interferon regulatory factor IRF11. | Melanoma differentiation-associated gene 5 (MDA5) initiates type I interferon (IFN) production by detecting cytosolic viral RNA. Mammalian MDA5 is an IFN-inducible gene and controlled by IFN regulatory factor 1 (IRF1). Teleost MDA5 also induces type I IFN production in response to viruses, yet its regulation remains la... |
39824169 | Molecular determinants of condensate composition. | Cells use membraneless compartments to organize their interiors, and recent research has begun to uncover the molecular principles underlying their assembly. Here, we explore how site-specific and chemically specific interactions shape the properties and functions of condensates. Site-specific recruitment involves prec... |
39823155 | Reservoir-Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone. | Implantable drug delivery systems are crucial for achieving sustained delivery of active compounds to specific sites or systemic circulation. In this study, a novel reservoir-type implant combining a biodegradable rate-controlling membrane with a drug-containing core prepared using direct compression techniques is deve... |
39822928 | Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field. | Due to their exceptional cell compatibility, biodegradability, and capacity to trigger tissue regeneration, extracellular matrix (ECM) materials have drawn considerable attention in tissue healing and regenerative medicine. Interestingly, these materials undergo continuous degradation and release antimicrobial peptides... |
39822732 | Genome-Wide Analysis of the <i>APETALA2/Ethylene-Responsive Factor</i> Gene Family in <i>Carthamus tinctorius L</i>. | The <i>APETALA2/ethylene-responsive factor (AP2/ERF)</i> superfamily represents a class of transcription factors involved in plant growth, development, and stress responses. <i>Carthamus tinctorius L</i>., also known as safflower, is an important plant whose flowers contain carthamin, an expensive aromatic pigment with... |
39822571 | Efficiency of carbon dioxide capture with metal substitutions in the MIL-88A metal-organic framework. | Carbon dioxide capture is a vital approach for mitigating air pollution and global warming. In this context, metal-organic frameworks are promising candidates. Particularly, MIL-88A (M), where the metal nodes (M) are connected to fumarate linkers in its structure, has demonstrated significant potential for CO<sub>2</su... |
39822567 | Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds. | In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available reviews on this topic, we focus specifically on MCRs with strong prospects in medicinal chemistry. Con... |
39822312 | Molecular interactions between surface-active ionic liquids based on 2-hydroxyethylammonium laurate with gabapentin: electrical conductivity and surface tension studies. | Surface active ionic liquids (SAILs), offer potential advantages for pharmaceutical applications. Given the low permeability of gabapentin, an antiepileptic drug, in the gastrointestinal tract as classified by the Biopharmaceutics Classification Systems (BCS), understanding the micellization behavior of SAILs is essent... |
39822141 | Defects Calculation and Accelerated Interfacial Charge Transfer in a Photoactive MOF-Based Heterojunction. | Photocatalytic hydrogen production is currently considered a clean and sustainable route to meet the energy and environmental issues. Among, heterojunction photocatalysts have been developed to improve their photocatalytic efficiency. Defect engineering of heterojunction photocatalysts is attractive due to it can perfo... |
39821605 | Atomically Dispersed Ni-N-C Catalysts for Electrochemical CO<sub>2</sub> Reduction. | The atomic dispersion of nickel in Ni-N-C catalysts is key for the selective generation of carbon monoxide through the electrochemical carbon dioxide reduction reaction (CO<sub>2</sub>RR). Herein, the study reports a highly selective, atomically dispersed Ni<sub>1.0%</sub>-N-C catalyst with reduced Ni loading compared ... |
39820820 | Green Assessment of Sensitive Spectrofluorimetric Methods for Simultaneous Estimation of Formoterol Fumarate and Fluticasone Propionate Using a Micelle-Mediated Approach. | Highly sensitive spectrofluorimetric methods were developed for the quantitative estimation of formoterol fumarate dihydrate (FFD) and fluticasone propionate (FP) in both authentic raw materials and marketed dosage forms using a micellar-enhanced spectrofluorimetric approach. The proposed methods are based on the deter... |
39820552 | Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. | Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including early immune aging. However, its precise cause remains elusive. Cellular senescence, a hallmark of aging marked by a perman... |
39820520 | Superior charge storage performance of optimized nickel cobalt carbonate hydroxide hydrate nanostructures for supercapacitor application. | In our work, we report superior electrochemical performance of optimized 3D nanostructured, nickel-cobalt carbonate hydroxide hydrate (Ni<sub>3 - x</sub>Co<sub>x</sub>-CHH (1 ≤ x ≤ 2)) materials with flower like morphology synthesised via one-step hydrothermal methods. A Ni rich sample (x = 1) demonstrate better specif... |
39820499 | Continuous photo-oxidation of methane to methanol at an atomically tailored reticular gas-solid interface. | Photo-oxidation of methane (CH<sub>4</sub>) using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) synthesized in situ from air and water under sunlight offers an attractive route for producing green methanol while storing intermittent solar energy. However, in commonly used aqueous-phase systems, photocatalysis efficien... |
39820129 | Structural basis for assembly and function of the Salmonella flagellar MS-ring with three different symmetries. | The flagellar MS-ring is the initial template for flagellar assembly and houses the flagellar protein export complex. The MS-ring has three parts of different symmetries within the ring structure by assembly of FliF subunits in two different conformations with distinct arrangements of three ring-building motifs, RBM1, ... |
39820072 | An unusual chiral-at-metal mechanism for BINOL-metal asymmetric catalysis. | Chiral binaphthols (BINOL)-metal combinations serve as powerful catalysts in asymmetric synthesis. Their chiral induction mode, however, typically relies on multifarious non-covalent interactions between the substrate and the BINOL ligand. In this work, we demonstrate that the chiral-at-metal stereoinduction mode could... |
39820070 | RNA Viruses, Toll-Like Receptors, and Cytokines: The Perfect Storm? | <h4>Background</h4>The interactions between viruses and the host immune response are nuanced and intricate. The cytokine response arguably plays a central role in dictating the outcome of virus infection, balancing inflammation, and healing, which is crucial to resolving infection without destructive immunopathologies.... |
39820032 | Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae. | Streptococcus pneumoniae (SPN) is a significant pathogen causing pneumonia and meningitis, particularly in vulnerable populations like children and the elderly. Available pneumonia vaccines have limitations since they only cover particular serotypes and have high production costs. The emergence of antibiotic-resistant ... |
39819845 | Ultra-sensitive fluorescence-activated droplet single-cell sorting based on Tetramer-HCR-EvaGreen amplification. | The current single-cell analysis technologies such as fluorescence-activated cell sorting (FACS) and fluorescence-activated droplet sorting (FADS) could decipher the cellular heterogeneity but were constrained by low sorting performance and cell viability. Here, an ultra-sensitive single-cell sorting platform has been ... |
39819563 | Effector proteins of Funneliformis mosseae BR221: unravelling plant-fungal interactions through reference-based transcriptome analysis, in vitro validation, and protein‒protein docking studies. | <h4>Background</h4>Arbuscular mycorrhizal (AM) fungi form a highly adaptable and versatile group of fungi found in natural and man-managed ecosystems. Effector secreted by AM fungi influence symbiotic relationship by modifying host cells, suppressing host defense and promoting infection to derive nutrients from the hos... |
39819479 | MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy. | Bioenergetic therapy based on tumor glucose metabolism is emerging as a promising therapeutic modality. To overcome the poor bioavailability and toxicity of arenobufagin (ArBu), a MOF-derived intelligent nanosystem, ZIAMH, was designed to facilitate energy deprivation by simultaneous interventions of glycolysis, OXPHOS... |
39819341 | Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability. | Traumatic brain injury is a leading cause of chronic neurologic disability and a risk factor for development of neurodegenerative disease. However, little is known regarding the pathophysiology of human traumatic brain injury, especially in the window after acute injury and the later life development of progressive neu... |
39819217 | Crucial role of the cGAS N terminus in mediating flowable and functional cGAS-DNA condensate formation via DNA interactions. | The DNA-sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid-liquid phase separation (LLPS) and enhances the enzymatic activity of cGAS. However, the regulatory mechanisms of the disordered N terminus remain unclear. Here, we showed that cGAS<... |
39819054 | Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis. | <h4>Background and objectives</h4>Gut microbial symbionts have been shown to influence the development of autoimmunity in multiple sclerosis (MS). Emerging research points to an important relationship between the microbial-IgA interface and MS pathophysiology. IgA-secreting B cells are observed in the MS brain, and shi... |
39818913 | Cyclodextrin Derivatives as Modulators for Enhanced Drug Delivery from Niosome Membrane: A Fluorescence Correlation Spectroscopy and Isothermal Titration Calorimetry Approach. | Designing efficient drug delivery systems for optimum therapeutic outcomes and minimum adverse effects remains a pivotal focus in pharmaceutical research. Understanding the nature of interactions between drugs and drug carriers and the drug-release mechanism are the key aspects for the development of effective delivery... |
39818896 | Mechanically interlocked two-dimensional polymers. | Mechanical bonds arise between molecules that contain interlocked subunits, such as one macrocycle threaded through another. Within polymers, these linkages will confer distinctive mechanical properties and other emergent behaviors, but polymerizations that form mechanical bonds efficiently and use simple monomeric bui... |
39818863 | Arene-Cucurbiturils: Benzene-Containing Cucurbituril[2,4] and Benzene-Containing Cucurbituril[3,6]. | Benzene-containing cucurbituril[2,4] and benzene-containing cucurbituril[3,6], the structures of cucurbit[<i>n</i>]urils with some glycoluril units replaced by benzene rings, are constructed through condensation of specific benzene-containing motifs. These novel macrocycles inherit cucurbit[<i>n</i>]urils' concave cavi... |
39818837 | Designing High Content Carbonylated β-Cyclodextrin/PBI Mixed Matrix Membrane as HT-PEM to Reduce H<sub>3</sub>PO<sub>4</sub> Loss. | The high-temperature proton exchange membranes suffer from weak binding strength for phosphoric acid molecules, which seriously reduce the fuel cell efficiency, especially operation stability. Introduction of microporous material in the membrane can effectively reduce the leaching of phosphoric acid. However, due to th... |
39818816 | Electroreduction-Driven Formation and Connectivity of Polyoxometalate Coordination Networks. | We present the synthesis of metal oxide coordination networks based on Preyssler-type polyoxoanions ([NaP<sub>5</sub>W<sub>30</sub>O<sub>110</sub>]<sup>14-</sup> and [NaP<sub>5</sub>MoW<sub>29</sub>O<sub>110</sub>]<sup>14-</sup>) bridged with metal-aquo complexes ([M(H<sub>2</sub>O)<sub><i>n</i></sub>]<sup><i>m+</i></s... |
39818811 | Bone Enzyme-Responsive Biodegradable Poly(propylene fumarate) and Polycaprolactone Polyphosphoester Dendrimer Cross-Linked via Click Chemistry for Bone Tissue Engineering. | Traditional polymer systems often rely on toxic initiators or catalysts for cross-linking, posing significant safety risks. For bone tissue engineering, another issue is that the scaffolds often take a longer time to degrade, inconsistent with bone formation pace. Here, we developed an enzyme-responsive biodegradable p... |
39817884 | Direct Methane to Methanol Conversion: An Overview of Non-Syn Gas Catalytic Strategies. | Direct methane to methanol conversion is a dream reaction in industrial chemistry, which takes inspiration from the biological methanol production catalysed by methane monooxygenase enzymes (MMOs). Over the years, extensive studies have been conducted on this topic by bioengineering the MMOs, and tailoring methods to i... |
39817865 | Unveiling the Origin of the Scale-Dependent Conductivity of Ni<sub>3</sub>(HITP)<sub>2</sub> Metal-Organic Framework Thin Films. | Conductive metal-organic frameworks (MOFs) are crystalline, intrinsically porous materials that combine remarkable electrical conductivity with exceptional structural and chemical versatility. This rare combination makes these materials highly suitable for a wide range of energy-related applications. However, the elect... |
39817863 | Metal-Modified Zr-MOFs with AIE Ligands for Boosting CO<sub>2</sub> Adsorption and Photoreduction. | The design and synthesis of metal-organic frameworks (MOFs) with outstanding light-harvesting and photoexcitation for artificial photocatalytic CO<sub>2</sub> reduction is an attractive but challenging task. In this work, a novel aggregation-induced emission (AIE)-active ligand, tetraphenylpyrazine (PTTBPC) is proposed... |
39817860 | Molecular Determinants of Optical Modulation in ssDNA-Carbon Nanotube Biosensors. | Most traditional optical biosensors operate through molecular recognition, where ligand binding causes conformational changes that lead to optical perturbations in the emitting motif. Optical sensors developed from single-stranded DNA-functionalized single-walled carbon nanotubes (ssDNA-SWCNTs) have started to make use... |
39817743 | Autoinducer-2 enhances the defense of <i>Vibrio furnissii</i> against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system. | As a universal language across the bacterial kingdom, the quorum sensing signal autoinducer-2 (AI-2) can coordinate many bacterial group behaviors. However, unknown AI-2 receptors in bacteria may be more than what has been discovered so far, and there are still many unknown functions for this signal waiting to be explo... |
39817733 | Leveraging Ergonomics and Human Factors (E/HF) for community impact: what have we learned about how to make a difference. | Ergonomics and Human Factors (E/HF) practitioners are increasingly engaged in projects meant to centre underserved communities and reduce inequities. The subdiscipline of E/HF that has emerged to explore the application of E/HF in this way is called community ergonomics. In this qualitative-descriptive study, we reflec... |
39817728 | Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations. | Viral adhesion to host cells is a critical step in infection for many viruses, including monkeypox virus (MPXV). In MPXV, the H3 protein mediates viral adhesion through its interaction with heparan sulfate (HS), yet the structural details of this interaction have remained elusive. Using AI-based structural prediction t... |
39817720 | Target-agnostic identification of human antibodies to <i>Plasmodium falciparum</i> sexual forms reveals cross-stage recognition of glutamate-rich repeats. | Circulating sexual stages of <i>Plasmodium falciparum (Pf</i>) can be transmitted from humans to mosquitoes, thereby furthering the spread of malaria in the population. It is well established that antibodies can efficiently block parasite transmission. In search for naturally acquired antibodies targets on sexual stage... |
39817693 | Supramolecularly Built Local Electric Field Microenvironment around Cobalt Phthalocyanine in Covalent Organic Frameworks for Enhanced Photocatalysis. | The local electric field (LEF) plays an important role in the catalytic process; however, the precise construction and manipulation of the electric field microenvironment around the active site remains a significant challenge. Here, we have developed a supramolecular strategy for the implementation of a LEF by introduc... |
39817611 | Molecular Insights into the Adsorption of Deposit Control Additives from Hydrocarbon Fuels. | Engine deposits can reduce performance and increase emissions, particularly for modern direct-injection fuel delivery systems. Surfactants known as deposit control additives (DCAs) adsorb and self-assemble on the surface of deposit precursors to keep them suspended in the fuel. Here, we show how molecular simulations c... |
39817448 | A new twist on superantigen-activated autoimmune disease. | Superantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the JCI, McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory ... |
39817405 | Hierarchical Selenium-Doped Nickel-Cobalt Hybrids on Carbon Paper for the Overall Water-Splitting Electrocatalytic System. | Designing and constructing hierarchically structured materials with heterogeneous compositions is the key to developing an effective catalyst for overall water-splitting applications. Herein, we report the fabrication of hollow-structured selenium-doped nickel-cobalt hybrids on carbon paper as a self-supported electrod... |
39817303 | An alternative approach to the detection of latent fingermarks using [Eu<sub>2</sub>(BDC)3(H<sub>2</sub>O)<sub>2</sub>], a luminescent non-toxic MOF powder. | Fingermarks are important forensic evidence for identifying people. In this work, luminescent MOF [Eu<sub>2</sub>(BDC)<sub>3</sub>(H<sub>2</sub>O)<sub>2</sub>] (herein referred as EuBDC) was tested as a potential latent fingermark (LF) luminescent developer powder and its acute toxicity evaluated following OECD protoco... |
39815831 | Supramolecular Combination Chemotherapy: Directly Inducing Immunogenic Cell Death To Inhibit Tumor Metastasis via Host-Guest Interactions. | Tumor metastasis is a difficult clinical problem to solve due to tumor heterogeneity and the emergence of antiapoptotic clones driven by tumor evolution. Clinical combination chemotherapy remains a standard treatment for solid metastasis tumors but with worse treatment efficiency. It is worth exploring a high-efficienc... |
39815120 | Lampbrush chromosomes of Danio rerio. | Danio rerio, commonly known as zebrafish, is an established model organism for the developmental and cell biology studies. Although significant progress has been made in the analysis of the D. rerio genome, cytogenetic studies face challenges due to the unclear identification of chromosomes. Here, we present a novel ap... |
39785146 | Competitive Coordination and Dual Interphase Regulation of MOF-Modified Solid-State Polymer Electrolytes for High-Performance Sodium Metal Batteries. | Solid-state polymer electrolytes (SPEs) have emerged as prominent candidates for solid-state sodium metal batteries (SMBs) due to their enhanced flexibility and reduced interfacial resistance. However, their performance is limited by poor Na<sup>+</sup> conductivity at room temperature, disordered ion transport propert... |
39780747 | g-C<sub>3</sub>N<sub>4</sub> S-Scheme Homojunction through Van der Waals Interface Regulation by Intrinsic Polymerization Tailoring for Enhanced Photocatalytic H<sub>2</sub> Evolution and CO<sub>2</sub> Reduction. | The effective S-scheme homojunction relies on the precise regulation of band structure and construction of advantaged charge migration interfaces. Here, the electronic structural properties of g-C<sub>3</sub>N<sub>4</sub> were modulated through meticulous polymerization of self-assembled supramolecular precursors. Expe... |
39777838 | Porous Supramolecular Crystalline Materials for Photocatalysis. | Porous supramolecular crystalline materials (PSCMs), such as hydrogen-bonded organic frameworks (HOFs), π frameworks, can be defined as a type of porous supramolecular assemblies stabilized by hydrogen-bonding, π-π stacking and other non-covalent interactions. Benefiting from the unique features of mild synthesis condi... |
39777778 | Scalable and Low-Energy Synthesis of Metal-Organic Frameworks by a Seed-Mediated Approach. | The synthesis of metal-organic frameworks (MOFs) by low energy input has been a long-term target for practical applications yet remains a great challenge. Herein, we developed a low-energy MOF growth strategy at a temperature down to 50 °C by simply introducing seeds into the reaction system. The MOFs are continuously ... |
39756683 | Nanoemulsion-based pseudopolyrotaxane hydrogel for enhanced corneal bioavailability and treatment of corneal inflammation. | Corneal inflammation, a condition that can potentially lead to blindness, is often treated with topical eye drops. However, the limited ocular drug bioavailability of the eye drops necessitates frequent dosing. Herein, a nanoemulsion-based pseudopolyrotaxane hydrogel was fabricated to improve corneal bioavailability an... |
39749723 | Photoresponsive Helical Foldamers: Conformational Control Through Double Helix Formation and Light-Induced Protonation. | Helical foldamers constitute particularly relevant targets in the field of host-guest chemistry, be that as hosts or substrates. In this context, the strategies reported so far to control the dimensions and shape of foldamers mainly involve modifications of the skeleton through covalent synthesis. Herein, we prepared a... |
39745771 | Scalable Mechanochemical Synthesis of Biotin[6]uril. | Biotin[6]uril, a chiral, water-soluble and anion binding macrocycle, is formed via dynamic covalent chemistry. In this study, we present a scalable and high-yielding synthesis of biotin[6]uril via a mechanochemical solid-state approach. The optimized protocol involves mechanical grinding of solid d-biotin with paraform... |
39714411 | Synergistic effect promoting proton transport in metal-organic framework aerogels. | One of the significant challenges encountered by metal-organic frameworks (MOFs) in proton conduction is their limited processability. In this study, we successfully synthesized UiO-66-COOH aerogel and UiO-66-2COOH aerogel, which exhibit high proton conductivities and remarkable temperature cycling stability in terms o... |
39711351 | Cu-MOF-based targeted nanomedicine utilizing biorthogonally catalyzed chemotherapy and chemodynamic therapy with spatiotemporal orchestration to treat hepatocellular carcinoma. | A nanomedicine was developed using a Cu-based metal-organic framework (MOF) to co-deliver Cu(I) and prodrugs for targeted biorthogonally catalyzed chemotherapy and chemodynamic therapy of hepatocellular carcinoma. |
39711326 | Design of an anti-PD-L1-mediated MOF nanodrug delivery system using terpyridine-metal coordination for tumor theranostics. | An anti-PD-L1 mediated nanodrug delivery system is developed by modifying the MOF surface and using Tpy-Gd<sup>3+</sup>-Tpy coordination chemistry, enabling the simultaneous delivery of chemotherapy and immunotherapy drugs. The platform enables regulated drug release and integrates multiple imaging modalities, promotin... |
39688274 | Recent progress using novel tetraphenylethylene-based macrocyclic hosts in water. | Macrocyclic structures are popular in supramolecular chemistry and have enjoyed considerable success as platforms for elaboration to container compounds and new materials. Host/guest studies in organic media have relied heavily on structures derived from crown ethers, calixarenes, cucurbiturils, resorcinarenes and pill... |
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