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39668770 | Bimetallic metal-organic framework based dispersive solid phase extraction followed by using a carbon dot solution as the elution solvent; application in the extraction of imidacloprid and acetamiprid from pepper samples. | This study focuses on the dispersive solid phase extraction technique for the efficient extraction and enrichment of imidacloprid and acetamiprid from pepper samples. A synthesized sorbent was used for this purpose. Once the target analytes were adsorbed, the sorbent was separated using a centrifuge and the analytes we... |
39635820 | Tough, durable and strongly bonded self-healing cartilage-mimicking noncovalently assembled hydrogel nanostructures: the interplay between experiment and theory. | High-strength, strongly bonded and self-healing materials are of great interest for several applications; however, the experimental and <i>in silico</i> design of all such properties in a single material is challenging. In the present work, inspired by cartilage tissue, polyacrylamide (PAM)-based tough and durable dime... |
39629505 | Helical magnetism in poly(aniline-<i>co</i>-ferrocene): structure and magnetism. | This study reports the synthesis and characterisation of a ferrocene-based conjugated polymer and a chiral composite. The precursor copolymer was synthesised from 1,3-phenylenediamine and 1,1'-dibromoferrocene <i>via</i> Buchwald-Hartwig polycondensation. This polymerisation process increased the effective conjugation ... |
39623942 | Bioinspired solid-state nanochannels for molecular analysis. | The acute sensory behaviour in living organisms relies on the highly efficient transport behaviour of ions in biological nanochannels, which has inspired the design and applications of artificial solid-state nanochannels in the field of sensitive analysis. The application of nanochannels for analysis is now widely inve... |
39620325 | Molecular interactions driving the complexation of rose bengal by triazine-carbosilane dendrons. | Amphiphilic dendrons or Janus dendrimers self-assembling into nanoscale vesicles offer promising avenues for drug delivery. Triazine-carbosilane dendrons have shown great potential for the intracellular delivery of rose bengal, additionally enhancing its phototoxic activity through non-covalent interactions. Thus, unde... |
39601631 | α-D Nucleoside Based Self-Healing Supramolecular Hydrogels Derived from the α-D Anomers of 2'-Deoxyguanosine and Fluorescent 8-Azapurine 2'-Deoxyribofuranosides. | Self-assembly of α-D nucleosides to supramolecular hydrogels is described in detail. Hydrogel formation is studied on α-D 2'-deoxyguanosine (α-dG), and the fluorescent 8-azapurine α-D nucleosides 2-amino-8-aza-2'-deoxyadenosine (α-2-NH<sub>2</sub>-z<sup>8</sup>A<sub>d</sub>) and 8-aza-2'-deoxyisoguanosine (α-z<sup>8</s... |
39527720 | Transformative Therapies for Depression: Postpartum Depression, Major Depressive Disorder, and Treatment-Resistant Depression. | Depressive disorders present an enormous global public health burden. A notable treatment gap exists between the prevalence of depression and our ability to provide rapid-acting, effective treatment that achieves remission. Brexanolone and zuranolone, the first US Food and Drug Administration-approved drugs for postpar... |
38644746 | A chemodosimetric chemosensor for the ratiometric detection of nerve agent-mimic DCP in solution and vapor phases. | Nerve agents are among the most deadly and lethal chemical warfare agents (CWAs). Rapid identification is crucial for specialized individuals to take action against dangerous drugs. This paper describes the synthesis and characterisation of a probe (MNFZ) based on the methoxy naphthalene-furoic hydrazide group. The pro... |
40778213 | Decoding the Interplay of Hydrogen Bonding, Dispersion, and Steric Interactions in Conformational Isomerism Among Functionalized Pillar[n]arenes. | Pillar[n]arenes have garnered popularity due to their unique pillar-shaped structure, which results in hydrophobic cavities. These cavities facilitate the formation of inclusion complexes with guest molecules through non-covalent interactions such as π - π stacking, hydrogen bonding, and van der Waals interactions. Suc... |
40657199 | Advances in MEMS, Optical MEMS, and Nanophotonics Technologies for Volatile Organic Compound Detection and Applications. | Volatile organic compounds (VOCs) are a class of organic compounds with high vapor pressure and low boiling points, widely present in both natural environments and human activities. VOCs released from various sources not only contribute to environmental pollution but also pose threats to ecosystems and human health. Mo... |
40015933 | Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer. | Prostate cancer is the second most common cancer in men, accounting for 14.1% of new cancer cases in 2020. The aggressiveness of prostate cancer is highly variable, depending on its grade and stage at the time of diagnosis. Despite recent advances in prostate cancer treatment, some patients still experience recurrence ... |
39936106 | Recent advances in nutritional metabolism studies on SARS-CoV-2 infection. | In the context of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), metabolic research has become crucial for in-depth exploration of viral infection mechanisms and in searching for therapeutic strategies. This paper summarizes the interrelationship... |
39901946 | Enhancement of quality induced by ultrasonic-assisted stewing improved the nutritional concentration, emulsifying property, and flavor characteristic of the chicken soup. | To investigate the effects of ultrasonic-assisted stewing (UAS) on the quality of chicken soup, the nutritional content, emulsifying properties and flavor characteristic were detected, and the underlying mechanisms were analyzed. The results showed that UAS led to a milky appearance, improved nutrient content and emuls... |
39897928 | SARS-CoV-2 drug resistance and therapeutic approaches. | In light of the transition of COVID-19 from a pandemic to an endemic phase, there is still a dire need to address challenges associated with drug resistance, particularly among immunocompromised and high-risk populations. This review explores the current state of research on SARS-CoV-2 drug resistance and underscores t... |
39895717 | Hydroxyl-Incorporated Microporous Polymer Comprising 3D Triptycene for Selective Capture of CO<sub>2</sub> over N<sub>2</sub> and CH<sub>4</sub>. | The rising CO<sub>2</sub> concentration in the atmosphere contributes significantly to global warming, necessitating effective carbon capture techniques. Amine-based solvents are widely employed for the chemisorption of CO<sub>2</sub>, although they have drawbacks, such as degradation, corrosion, and high regeneration ... |
39886600 | Activatable Porphyrin-Based Sensors, Photosensitizers and Combination Therapeutics. | Porphyrins, known as the "pigments of life", have evolved from their natural roles into versatile tools for biomedical applications. The development of activatable porphyrins has significantly expanded their utility, enabling precise responses to a carefully selected target analyte. These advances have broadened their ... |
39886576 | Inverse Design of 2D Altermagnetic Metal-Organic Framework Monolayers from Hückel Theory of Nonbonding Molecular Orbitals. | Altermagnets, characterized by spontaneous spin-splitting without net magnetization, are challenging to realize due to their unique spin group symmetries. Two-dimensional (2D) magnetic metal-organic frameworks (MOFs), with tunable topologies and spins, offer promising platforms for achieving altermagnetism. In this stu... |
39885788 | Memory Decline and Aberration of Synaptic Proteins in X-Linked Moesin Knockout Male Mice. | <h4>Objective</h4>This study aims to investigate may moesin deficiency resulted in neurodevelopmental abnormalities caused by negative impact on synaptic signaling ultimately leading to synaptic structure and plasticity.<h4>Methods</h4>Behavioral assessments measured neurodevelopment (surface righting, negative geotaxi... |
39881992 | <i>In silico</i> analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation. | <h4>Background</h4>HCV genotypes are 30-35% polymorphic at the nucleotide level, while subtypes within the same genotype differ by nearly 20%. Although previous studies have shown the immune escape potential of several mutations within the HCV proteins, little is known about the effect of genotype/subtype-specific gene... |
39881959 | Approaches and applications in transdermal and transpulmonary gene drug delivery. | Gene therapy has emerged as a pivotal component in the treatment of diverse genetic and acquired human diseases. However, effective gene delivery remains a formidable challenge to overcome. The presence of degrading enzymes, acidic pH conditions, and the gastrointestinal mucus layer pose significant barriers for geneti... |
39881862 | Exploring the dielectric properties of herbal medicine and modern pharmaceuticals: an integrative review. | The integration of herbal medicine with modern pharmaceuticals offers a novel approach to addressing complex healthcare challenges. This study investigates the role of dielectric spectroscopy in analysing key physicochemical properties such as solubility, stability, and molecular interactions. The findings reveal that ... |
39881805 | Case report: 10-year follow-up of a patient with neuronal intranuclear inclusion disease and a literature review. | Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disease with variable clinical manifestations. High signals on diffusion-weighted imaging (DWI) along the corticomedullary junction (CMJ) are a specific feature of NIID. Only a few reports have observed patients for a long period an... |
39880502 | Perylene diimide based fluorescent sensors for aqueous detection of perfluorooctane sulfonate (PFOS). | <h4>Background</h4>Perfluorooctane sulfonate (PFOS), one of the most harmful members of the large group of per- and poly-fluoroalkyl substances (PFAS), is notorious for its environmental persistence, bioaccumulation, and toxic effects, raising serious environmental and health concerns. Developing rapid and sensitive me... |
39861759 | Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the Potentialities of Resveratrol-Loaded Lipid Nanoparticles and Hydroxyapatite to Promote Alveolar Wound Healing. | <b>Background/Objectives</b>: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within a hydrophilic matrix, ... |
39861761 | Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy. | Curcumin, a bioactive compound derived from the rhizome of <i>Curcuma longa</i> L., has garnered significant attention for its potent anticancer properties. Despite its promising therapeutic potential, its poor bioavailability, rapid metabolism, and low water solubility hinder curcumin's clinical application. Nanotechn... |
39861757 | Nanotechnology-Based Drug Delivery Systems, 2nd Edition. | Nanotechnology is a promising and rapidly developing area in the 21st century, which affects various fields of science: physics, chemistry, biology, engineering, microelectronics, and medicine [...]. |
39861756 | Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis. | Brain diseases pose significant treatment challenges due to the restrictive nature of the blood-brain barrier (BBB). Recent advances in targeting macromolecules offer promising avenues for overcoming these obstacles through receptor-mediated transcytosis (RMT). We summarize the current progress in targeting brain drug ... |
39861577 | Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer's Disease. | Alzheimer's disease (AD) is a neurodegenerative condition characterized by a gradual decline in cognitive function, for which few effective treatments exist. This study investigated the neuroprotective potential of <i>Oroxylum indicum</i> root extract and its key constituents (baicalein, chrysin, oroxylin A) against AD... |
39861420 | Effect of <i>Ficus pumila</i> L. on Improving Insulin Secretory Capacity and Resistance in Elderly Patients Aged 80 Years Old or Older Who Develop Diabetes After COVID-19 Infection. | (1) Background: It has been reported that people affected by COVID-19, an infectious disease caused by SARS-CoV-2, suffer from various diseases, after infection. One of the most serious problems is the increased risk of developing diabetes after COVID-19 infection. However, a treatment for post-COVID-19 infection diabe... |
39861281 | Improved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes. | Following implantation, infections, inflammatory reactions, corrosion, mismatches in the elastic modulus, stress shielding and excessive wear are the most frequent reasons for orthopedic implant failure. Natural polymer-based coatings showed especially good results in achieving better cell attachment, growth and tissue... |
39861278 | Adsorption and Bulk Assembly of Quaternized Hydroxyethylcellulose-Anionic Surfactant Complexes on Negatively Charged Substrates. | This study examines the adsorption and bulk assembly behaviour of quaternized hydroxyethylcellulose ethoxylate (QHECE)-sodium dodecyl sulphate (SDS) complexes on negatively charged substrates. Due to its quaternized structure, QHECE, which is used in several industries, including cosmetics, exhibits enhanced electrosta... |
39861166 | Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies. | Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of a wide range of brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and inter... |
39861161 | Mechanisms of Copper-Induced Autophagy and Links with Human Diseases. | As a structural and catalytic cofactor, copper is involved in many biological pathways and is required for the biochemistry of all living organisms. However, excess intracellular copper can induce cell death due to its potential to catalyze the generation of reactive oxygen species, thus copper homeostasis is strictly ... |
39861038 | The Anthelmintic Activity of <i>Nepeta racemosa</i> Lam. Against Gastrointestinal Nematodes of Sheep: Rosmarinic Acid Quantification and In Silico Tubulin-Binding Studies. | Gastrointestinal nematodes (GINs) inflict significant economic losses on sheep and goat farming globally due to reduced productivity and the development of anthelmintic resistance. Sustainable control strategies are urgently needed including the exploration of medicinal plants as safer alternatives to chemical anthelmi... |
39860184 | Entire Encapsulation of Thymopentin by Extended Biphen[3]arene Carboxylate for Improving Plasma Stability. | Peptide-based therapy is appealing in modern medicine owing to its high activity and excellent biocompatibility. Poor stability, leading to unacceptable bioavailability, severely constrains its clinical application. Here, we proposed a general supramolecular approach for improving the plasma resistance of a commerciall... |
39860183 | «Green-Ligand» in Metallodrugs Design-Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity. | The interaction of sodium phytate hydrate C<sub>6</sub>H<sub>18</sub>O<sub>24</sub>P<sub>6</sub>·xNa·yH<sub>2</sub>O (phytNa) with Cu(OAc)<sub>2</sub>·H<sub>2</sub>O and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu<sub>4</sub>(H<sub>2</sub>O)<sub>4</sub>(phen)<sub>4</sub>(phyt)]·2Na<sup>+</sup... |
39859849 | Metal-Organic Framework-Assisted Atmospheric Water Harvesting Enables Cheap Clean Water Available in an Arid Climate: A Perspective. | Extracting water directly from the atmosphere seems to be a perfect way to solve the water scarcity facing 2 billion people; however, traditional Atmospheric Water Harvesting (AWH) lacks the ability to adsorb water molecules in an arid climate. Porous materials are capable of assisting water adsorption; however, curren... |
39859845 | Nano-Fibrillated Bacterial Cellulose Nanofiber Surface Modification with EDTA for the Effective Removal of Heavy Metal Ions in Aqueous Solutions. | Nano-fibrillated bacterial cellulose (NFBC) has very long fibers (>17 μm) with diameters of approximately 20 nm. Hence, they have a very high aspect ratio and surface area. The high specific surface area of NFBC can potentially be utilized as an adsorbent. However, NFBC has no functional groups that can bind metal ions... |
39859423 | Advances and Future Trends in Nanozyme-Based SERS Sensors for Food Safety, Environmental and Biomedical Applications. | Nanozymes, a kind of nanoparticles with enzyme-mimicking activities, have attracted considerable attention due to their robust catalytic properties, ease of preparation, and resistance to harsh conditions. By combining nanozymes with surface-enhanced Raman spectroscopy (SERS) technology, highly sensitive and selective ... |
39859413 | Utilization of Cannabidiol in Post-Organ-Transplant Care. | Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, <i>Cannabis sativa</i>, widely recognized for its therapeutic potential. While cannabis has been utilized for medicinal purposes since ancient times, its psychoactive and addictive properties led to its prohibition in 1937, with only the medi... |
39859408 | Long Non-Coding RNAs in Malignant Human Brain Tumors: Driving Forces Behind Progression and Therapy. | Long non-coding RNAs (lncRNAs) play a pivotal role in regulating gene expression and are critically involved in the progression of malignant brain tumors, including glioblastoma, medulloblastoma, and meningioma. These lncRNAs interact with microRNAs (miRNAs), proteins, and DNA, influencing key processes such as cell pr... |
39859402 | A Dual-Cycle Isothermal Amplification Method for microRNA Detection: Combination of a Duplex-Specific Nuclease Enzyme-Driven DNA Walker with Improved Catalytic Hairpin Assembly. | The association between microRNAs and various diseases, especially cancer, has been established in recent years, indicating that miRNAs can potentially serve as biomarkers for these diseases. Determining miRNA concentrations in biological samples is crucial for disease diagnosis. Nevertheless, the stem-loop reverse tra... |
39859397 | Establishment of a Yeast Two-Hybrid-Based High-Throughput Screening Model for Selection of SARS-CoV-2 Spike-ACE2 Interaction Inhibitors. | The recent coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has exerted considerable impact on global health. To prepare for rapidly mutating viruses and for the forthcoming pandemic, effective therapies targeting the critical stages of the viral life... |
39857428 | DNA Methylation and Transcriptome Profiling Reveal the Role of the Antioxidant Pathway and Lipid Metabolism in <i>Plectropomus leopardus</i> Skin Color Formation. | Leopard coral grouper (<i>Plectropomus leopardus</i>), possessing a distinct red body color, is an important species in commercial markets; however, the high ratio of black individuals under intensive cultivation has limited the commercial value of the species. To dissect the regulatory mechanisms underlying the red sk... |
39856921 | Development of Alginate-Chitosan Bioactive Films Containing Essential Oils for Use in Food Packaging. | The effect on the physical, mechanical, and antibacterial properties of films composed of alginate-chitosan with the incorporation of oregano (EOO) or thyme (EOT) essential oils was evaluated. These films showed a thickness between 37.7 and 38.2 µm, with no significant differences for essential oil content. Water vapor... |
39855098 | Functionalized UiO-66 induces shallow electron traps in heterojunctions with InN for enhanced photocathodic water splitting. | Indium nitride (InN) exhibited significant potential as a photoelectrode material for photoelectrochemical (PEC) water splitting, attributed to its superior light absorption, high electron mobility, and direct bandgap. However, its practical application was constrained by rapid carrier recombination occurring within th... |
39852582 | Biodegradable Polymers and Textiles. | The increasing interest in developing biodegradable polymers through chemical treatments, microorganisms, and enzymes highlights a commitment to environmentally friendly disposal methods [...]. |
39852395 | Silymarin as a Therapeutic Agent for Hepatocellular Carcinoma: A Multi-Approach Computational Study. | <h4>Background</h4>Hepatocellular carcinoma (HCC) is a prevalent and lethal form of liver cancer with limited treatment options. Silymarin, a flavonoid complex derived from milk thistle, has shown promise in liver disease treatment due to its antioxidant, anti-inflammatory, and anticancer properties. This study aims to... |
39852104 | Wearable Sensors for Plants: Status and Prospects. | The increasing demand for smart agriculture has led to the development of agricultural sensor technology. Wearable sensors show great potential for monitoring the physiological and surrounding environmental information for plants due to their high flexibility, biocompatibility, and scalability. However, wearable sensor... |
39852103 | SERS Detection of Hydrophobic Molecules: Thio-β-Cyclodextrin-Driven Rapid Self-Assembly of Uniform Silver Nanoparticle Monolayers and Analyte Trapping. | High-sensitivity and repeatable detection of hydrophobic molecules through the surface-enhanced Raman scattering (SERS) technique is a tough challenge because of their weak adsorption and non-uniform distribution on SERS substrates. In this research, we present a simple self-assembly protocol for monolayer SERS mediate... |
39852102 | Next-Generation Potentiometric Sensors: A Review of Flexible and Wearable Technologies. | In recent years, the field of wearable sensors has undergone significant evolution, emerging as a pivotal topic of research due to the capacity of such sensors to gather physiological data during various human activities. Transitioning from basic fitness trackers, these sensors are continuously being improved, with the... |
39852037 | Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications. | Biosensors, which combine physical transducers with biorecognition elements, have seen significant advancement due to the heightened interest in rapid diagnostic technologies across a number of fields, including medical diagnostics, environmental monitoring, and food safety. In particular, polydiacetylene (PDA) is gain... |
39845872 | Introducing halogen-bonded gates into zeolitic frameworks for efficient benzene/cyclohexene/cyclohexane separation. | The separation of C<sub>6</sub> cyclic hydrocarbons (benzene, cyclohexene, and cyclohexane) is one of the most challenging chemical processes in the petrochemical industry. Herein, we design and synthesize a new SOD-topology metal azolate framework (MAF) with aperture gating behaviour controlled by C-Br⋯N halogen bonds... |
39844819 | Advancements and Future Directions of Dual-Target Chimeric Antigen Receptor T-Cell Therapy in Preclinical and Clinical Studies. | In recent years, chimeric antigen receptor T-cell (CAR-T) therapy has made groundbreaking progress in the treatment of various cancer types, particularly hematological malignancies. In the meantime, various preclinical and clinical studies have extensively explored dual-target CAR-T therapies which can be designed to r... |
39837229 | Detecting the saddling deformations in nickel meso-phenyl substituted porphyrins using low-frequency Raman characteristic peaks. | The out-of-plane (OOP) deformations of metalloporphyrins macrocycle are closely related to their biological functions, and Raman spectroscopy is a powerful tool for investigating OOP deformations. However, due to the interplay of electronic structure, substituents, porphyrin macrocycle in-plane (IP) and OOP deformation... |
39832407 | CRISPR analysis based on Pt@MOF dual-modal signal for multichannel fluorescence and visual detection of norovirus. | Norovirus is a globally prevalent pathogen that causes acute viral gastroenteritis across all age groups, characterized by its high infectivity and low infectious dose. Consequently, the development of rapid, sensitive, and accurate detection technologies for norovirus presents a significant challenge. In this study, w... |
39830683 | Raman active diyne-girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores. | Peptide stapling is an effective strategy to stabilise α-helical peptides, enhancing their bioactive conformation and improving physiochemical properties. In this study, we apply our novel diyne-girder stapling approach to the MDM2/MDMX α-helical binding region of the p53 transactivation domain. By incorporation of an ... |
39827561 | Multifunctional metal-organic frameworks-mediated colorimetric/photothermal immunosensor for highly sensitivity detection of dibutyl phthalate. | Dibutyl phthalate (DBP), a priority pollutant among phthalic acid esters (PAEs) exhibits significant reproductive and respiratory toxicity. In this study, a multifunctional metal-organic frameworks-mediated colorimetric/photothermal immunosensor was established for the quantitative detection of DBP. Firstly, a highly s... |
39827544 | Construction of 2D CoFe-MOF derived from LDH electrocatalyst for efficient oxygen and urea evolution. | Two-dimensional metal-organic framework (2D MOF) materials have significant development prospects in the technology of urea-assisted water electrolysis for hydrogen production. However, the poor conductivity, low mass permeability, and stability have limited their development in electrocatalysis. Here, CoFe-BDC is synt... |
39827509 | Tuning local matrix compliance accelerates mesenchymal stem cell chondrogenesis in 3D sliding hydrogels. | The mechanical properties of the extracellular matrix critically regulate stem cell differentiation in 3D. Alginate hydrogels with tunable bulk stiffness and viscoelasticity can modulate differentiation in 3D through mechanotransduction. Such enhanced differentiation is correlated with changes in the local matrix compl... |
39824399 | Facile and green fabrication of biodegradable aerogel from chitosan derivatives/modified gelatin as absorbent for oil removal. | Frequent oil spills have caused increasingly severe pollution of marine water bodies. As a result, exploring green and efficient aerogels to tackles oil pollution is in high demand. In this work, a unique strategy for preparing all-biomass aerogel was innovatively proposed. A series of all-biomass CW&BW@DCGA aerogels w... |
39824411 | The effect of different wall materials on the physicochemical properties and antioxidant activity of pomegranate peel polyphenols (PPP) microcapsules. | Pomegranate peel polyphenols (PPP) are natural compounds known for their various biological activities; however, they are easily degraded by environmental conditions, leading to a reduction in their biological activity and health benefits. Therefore, improving the stability of PPP is a critical question that needs to b... |
39823858 | Recent emerging trends in dendrimer research: Electrochemical sensors and their multifaceted applications in biomedical fields or healthcare. | Dendrimers enhance the selectivity and sensitivity of sensors through their synthetic, highly branched, three-dimensional structures and large surface area. This unique architecture enables precise functionalization with various recognition elements, significantly improving the specificity and sensitivity of electroche... |
39823046 | Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics. | Extracellular vesicles (EVs) are emerging as viable tools in cancer treatment due to their ability to carry a wide range of theranostic activities. This review summarizes different forms of EVs such as exosomes, microvesicles, apoptotic bodies, and oncosomes. It also sheds the light onto isolation methodologies, charac... |
39822773 | Macrocyclic peptides as a new class of targeted protein degraders. | Targeted protein degraders, in the form of proteolysis targeting chimaeras (PROTACs) and molecular glues, leverage the ubiquitin-proteasome system to catalytically degrade specific target proteins of interest. Because such molecules can be extremely potent, they have attracted considerable attention as a therapeutic mo... |
39819920 | Comparative effects of dual-task training versus combined exercise training in water and on land on patients with multiple sclerosis: a study protocol of a randomised factorial trial. | <h4>Introduction</h4>People with multiple sclerosis (PwMS) experience cognitive and motor impairments, including cognitive training and exercise training. This study compares dual task and combined exercise training in water and on land. Water-based training may enhance cognitive and motor function more effectively tha... |
39813445 | Confinement and Catalysis within <i>De Novo</i> Designed Peptide Barrels. | <i>De novo</i> protein design has advanced such that many peptide assemblies and protein structures can be generated predictably and quickly. The drive now is to bring functions to these structures, for example, small-molecule binding and catalysis. The formidable challenge of binding and orienting multiple small molec... |
39813402 | The TRP channels serving as chemical-to-electrical signal converter. | Biology uses many signaling mechanisms. Among them, calcium and membrane potential are two prominent mediators for cellular signaling. Transient receptor potential (TRP) melastatin 4 and 5 (TRPM4 and TRPM5), two calcium-activated monovalent cation-selective ion channels, offer a direct linkage between these two signals... |
39813389 | Asymmetric Amplification in Oxypalladation/Malononitrile Addition Cascade Enabled by Heterochiral-Assembly of Products. | An enantioselective oxypalladation/malononitrile addition cascade reaction of alkyne-tethered malononitriles was reported to synthesize enaminones bearing an all-carbon quaternary center. Using Pd(TFA)<sub>2</sub>/Pyox as a precatalyst, an array of enaminone products were obtained in moderate overall yields, with excel... |
39813356 | SMARCA4 regulates the NK-mediated killing of senescent cells. | Induction of senescence by chemotherapeutic agents arrests cancer cells and activates immune surveillance responses to contribute to therapy outcomes. In this investigation, we searched for ways to enhance the NK-mediated elimination of senescent cells. We used a staggered screen approach, first identifying siRNAs pote... |
39813358 | Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments. | Several human disorders, including Alzheimer's disease (AD), are characterized by the aberrant formation of amyloid fibrils. In many cases, the amyloid core is flanked by disordered regions, known as fuzzy coat. The structural properties of fuzzy coats, and their interactions with their environments, however, have not ... |
39813333 | Soft nanoforest of metal single atoms for free diffusion catalysis. | Metal single atoms are of increasing importance in catalytic reactions. However, the mass diffusion is yet substantially limited by the confined surface of the support in comparison to homogeneous catalysis. Here, we demonstrate that cylindrical micellar brushes with highly solvated poly(2-vinylpyridine) coronas can im... |
39813328 | Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis. | The rare metal element molybdenum functions as a cofactor in molybdoenzymes that are essential to life in almost all living things. Molybdate can be captured by the periplasmic substrate-binding protein ModA of ModABC transport system in bacteria. We demonstrate that ModA plays crucial roles in growth, multiple metabol... |
39813335 | Compressing slippery surface-assembled amphiphiles for tunable haptic energy harvesters. | A recurring challenge in extracting energy from ambient motion is that devices must maintain high harvesting efficiency and a positive user experience when the interface is undergoing dynamic compression. We show that small amphiphiles can be used to tune friction, haptics, and triboelectric properties by assembling in... |
39813251 | Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities. | On the one hand, nature utilizes hierarchical assemblies to create complex biological binding pockets, enabling ultrastrong recognition toward substrates in aqueous solutions. On the other hand, chemists have been fervently pursuing high-affinity recognition by constructing covalently well-preorganized stereoelectronic... |
39813162 | Proximity Labeling and Genetic Screening Reveal that DSG2 is a Counter Receptor of Siglec-9 and Suppresses Macrophage Phagocytosis. | Cancer cells present sialylated glycoconjugates that modulate the activity of various immune cells within the tumor microenvironment through trans interaction with immunosuppressive Siglec receptors. Identifying counter receptors for Siglecs can provide valuable targets for cancer immunotherapy, but it presents signifi... |
39813137 | A Durable Ag@MOF-545/QCM-Cotton Fabric with "Intelligent Bacteria-Capturing and Dual Antibacterial" Properties. | Cotton textiles with persistent antibacterial qualities are crucial in halting the spread of bacteria and other infections. However, fugitive bacteria and drug-resistant pathogens have rendered tremendous challenges in the development of cotton fabrics with long-lasting antibacterial efficacy. The work aimed to innovat... |
39813103 | Targeted Enrichment of Nucleic Acid Bionic Arms Enhances the Hydrolysis Activity of Nanozymes for Degradation and Real-Time Monitoring of Organophosphorus Pesticides in Water. | Organophosphorus pesticides (OPs) pose significant environmental and health risks, and their detoxification through catalytic hydrolysis using zirconium-based metal-organic frameworks (Zr-MOFs) has attracted considerable interest due to the strong Lewis acid metal ions. Albeit important, the defects of the materials fo... |
39818213 | Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation. | High-risk human papillomavirus E6 oncoprotein is a model system for the recognition and degradation of cellular p53 tumor suppressor protein. There remains a gap in the understanding of the ubiquitin transfer reaction, including placement of the E6AP catalytic HECT domain of the ligase concerning the p53 substrate and ... |
39818205 | Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning. | Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and species-specific tropism. Herein, we conducted combinatorial binding studi... |
39816180 | A synthetic methodology toward π-extended porphyrin-rylenediimide conjugates. | In this work, we present a straightforward synthetic route for the preparation of functionalized β-<i>meso</i>-fused porphyrins, which are subsequently connected to rylendiimides. The resulting donor-acceptor-type conjugates exhibit intriguing optical properties, such as panchromatism and profoundly bathochromically sh... |
39816178 | <i>In situ</i> synthesis of ultrafine Cu(ii) metal immobilized on pectin hydrogel, modified by a CoFe<sub>2</sub>O<sub>4</sub>/Pr-SO<sub>3</sub>H nanocomposite as a green catalyst for reduction of nitro compounds and synthesis of 1<i>H</i>-tetrazoles. | Synthesis of 5-substituted 1<i>H</i>-tetrazoles and reduction of a variety of nitro compounds presents a promising solution for the pharmaceutical and agricultural industries. However, the development of green catalysts with superior catalytic performance for this reaction remains a significant challenge. This research... |
39816174 | Selective fluorescent probe for Tl<sup>3+</sup> ions through metal-induced hydrolysis and its application for direct assay of artificial urine. | In this research, we report a simple fluorescent probe designed to detect thallium(iii) ions (Tl<sup>3+</sup>) in artificial urine samples. The Tl<sup>3+</sup> signaling probe (TP-1) was readily prepared from 2-acetyl-6-methoxynaphthalene and hydrazine. In a pH 4.8 acetate buffer solution containing 1% (v/v) <i>N</i>,<... |
39816172 | Scalable ultrasound-assisted synthesis of hydroxy imidazole <i>N</i>-oxides and evaluation of their anti-proliferative activities; mechanistic insights into the deoximation of dioximes. | The development of synthetic methodologies that promote greener reactions have become so essential that it has slowly shaped the way chemists think about the construction of physiologically and chemically active compounds. The acid-catalyzed iminoketone - aldehyde condensations leading to Hydroxy imidazole <i>N</i>-oxi... |
39815733 | A Stable Zn(II) Metal-Organic Framework as Turn-On and Blue-Shift Fluorescence Sensor for Amino Acids and Dipicolinic Acid in Living Cells or Using Aerosol Jet Printing. | Amino acids and dipicolinic acid (DPA) are important biomarkers for identifying human health. Establishing rapid, accurate, sensitive, and simple assays is essential for disease prevention and early diagnosis. In this work, a novel Zn(II) metal-organic framework (MOF) with the formula {[Zn<sub>5</sub>(μ<sub>3</sub>-OH)... |
39815713 | New polymorphisms of Vkork1 gene related to anticoagulant resistance of rats and mice in Italy. | <h4>Background</h4>Anticoagulant rodenticides (ARs) are a very effective tool to control rodent pest populations. Nevertheless, AR resistance has been documented worldwide. ARs block the cycle of vitamin K, leading to the death of the animal by internal bleeding: mutations in Vkorc1 gene can cause resistance. The sprea... |
39815454 | Collagen Nanofiber-Lignin Composite Sponges with Adjustable Hierarchical Pore Structure for Efficient Low-Frequency Sound Absorption. | Current sound-absorbing materials, reliant on nonrenewable resources, pose sustainability and disposal challenges. This study introduces a novel collagen-lignin sponge (CLS), a renewable biomass-based material that combines collagen's acoustic properties with lignin's structural benefits. CLSs demonstrate high porosity... |
39815450 | Inflammation Targeting-Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa. | Inflammatory bowel disease (IBD) is characterized by intestinal mucosal damage that exacerbates inflammation and promotes disease recurrence. Although hydrogel-based therapies have shown potential for mucosal repair, challenges remain due to inadequate targeting and low hydrogel density, leading to ongoing infiltration... |
39815381 | Advances in Oxygen Evolution Reaction Electrocatalysts via Direct Oxygen-Oxygen Radical Coupling Pathway. | Oxygen evolution reaction (OER) is a cornerstone of various electrochemical energy conversion and storage systems, including water splitting, CO<sub>2</sub>/N<sub>2</sub> reduction, reversible fuel cells, and rechargeable metal-air batteries. OER typically proceeds through three primary mechanisms: adsorbate evolution ... |
39815320 | Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus. | Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, thereby minimizing diabetes-related complications. However, given the... |
39815286 | Exploring TNFR1: from discovery to targeted therapy development. | This review seeks to elucidate the therapeutic potential of tumor necrosis factor receptor 1 (TNFR1) and enhance our comprehension of its role in disease mechanisms. As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (... |
39815097 | Transducing chemical energy through catalysis by an artificial molecular motor. | Cells display a range of mechanical activities generated by motor proteins powered through catalysis<sup>1</sup>. This raises the fundamental question of how the acceleration of a chemical reaction can enable the energy released from that reaction to be transduced (and, consequently, work to be done) by a molecular cat... |
39815045 | Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates. | The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcription by restricting chromatin accessibility. However, the spatial organization and dynamics of chromatin compacted by gene-repressing factors are unknown. Here, using cryo-electron tomogr... |
39815044 | Eco-friendly sensing of hexavalent chromium ions via copper-doped carbon quantum dots: a fluorescent probe for water safety. | The hydrothermal synthesis is presented of copper-doped carbon dots (Cu-CDs) from citric acid, urea, and copper chloride, resulting in blue-fluorescent particles with stable emission at 438 nm when excited at 340 nm. Through comprehensive spectroscopic and microscopic characterization (FTIR, XPS, UV, and HRTEM), the Cu... |
39814991 | Orthogonalized human protease control of secreted signals. | Synthetic circuits that regulate protein secretion in human cells could support cell-based therapies by enabling control over local environments. Although protein-level circuits enable such potential clinical applications, featuring orthogonality and compactness, their non-human origin poses a potential immunogenic ris... |
39814955 | Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity. | We have assessed antiviral activity and induction of protective immunity of fusion-inhibitory lipopeptides derived from the C-terminal heptad-repeat domain of SARS-CoV-2 spike glycoprotein in transgenic mice expressing human ACE2 (K18-hACE2). The lipopeptides block SARS-CoV-2 infection in cell lines and lung-derived or... |
39814937 | DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer's disease. | Alzheimer's Disease (AD) significantly aggravates human dignity and quality of life. While newly approved amyloid immunotherapy has been reported, effective AD drugs remain to be identified. Here, we propose a novel AI-driven drug-repurposing method, DeepDrug, to identify a lead combination of approved drugs to treat A... |
39814896 | Bilayer nanographene reveals halide permeation through a benzene hole. | Graphene is a single-layered sp<sup>2</sup>-hybridized carbon allotrope, which is impermeable to all atomic entities other than hydrogen<sup>1,2</sup>. The introduction of defects allows selective gas permeation<sup>3-5</sup>; efforts have been made to control the size of these defects for higher selectivity<sup>6-9</s... |
39814890 | Targeting protein-ligand neosurfaces with a generalizable deep learning tool. | Molecular recognition events between proteins drive biological processes in living systems<sup>1</sup>. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules<sup>2-5</sup>. Despite recent advances, computational tools for the design of ne... |
39814798 | Chromosome-level genome assembly and annotation of largemouth bronze gudgeon (Coreius guichenoti). | Coreius guichenoti, mainly distributed in upstream regions of the Yangtze River China, is currently on the brink of extinction and listed as national secondary protected animal. In this study, we aimed to obtain the chromosome-level genome of C. guichenoti using PacBio and Hi-C techniques. According to the PacBio seque... |
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