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39814792 | Pressure treatment enables white-light emission in Zn-IPA MOF via asymmetrical metal-ligand chelate coordination. | Metal-organic frameworks that feature hybrid fluorescence and phosphorescence offer unique advantages in white-emitting communities based on their multiple emission centers and high exciton utilization. However, it poses a substantial challenge to realize superior white-light emission in single-component metal-organic ... |
39814741 | Visualizing stepwise evolution of carbon hybridization from sp<sup>3</sup> to sp<sup>2</sup> and to sp. | Regulating carbon hybridization states lies at the heart of engineering carbon materials with tailored properties but orchestrating the sequential transition across three states has remained elusive. Here, we visiualize stepwise evolution in carbon hybridizations from sp³ to sp² and to sp states via dehydrogenation and... |
39814727 | Integration of ordered porous materials for targeted three-component gas separation. | Separation of multi-component mixtures in an energy-efficient manner has important practical impact in chemical industry but is highly challenging. Especially, targeted simultaneous removal of multiple impurities to purify the desired product in one-step separation process is an extremely difficult task. We introduced ... |
39814724 | In-situ restructuring of Ni-based metal organic frameworks for photocatalytic CO<sub>2</sub> hydrogenation. | As the global quest for sustainable energy keeps rising, exploring novel efficient and practical photocatalysts remains a research and industrial urge. Particularly, metal organic frameworks were proven to contribute to various stages of the carbon cycle, from CO<sub>2</sub> capture to its conversion. Herein, we report... |
39814714 | Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer. | The efficacy of cancer immunotherapy relies on a sufficient amount of functional immune cells. Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. However, the improvement in efficacy is unsatisfactory with concern about inducing systemic ... |
39814713 | Illuminating the impact of N-terminal acetylation: from protein to physiology. | N-terminal acetylation is a highly abundant protein modification in eukaryotic cells. This modification is catalysed by N-terminal acetyltransferases acting co- or post-translationally. Here, we review the eukaryotic N-terminal acetylation machinery: the enzymes involved and their substrate specificities. We also provi... |
39813085 | MAL2 and rab17 selectively redistribute invadopodia proteins to laterally-induced protrusions in hepatocellular carcinoma cells. | MAL2 (myelin and lymphocyte protein 2) and rab17 have been identified as hepatocellular carcinoma tumor suppressors. However, little is known how their functions in hepatic polarized protein sorting/trafficking translate into how they function in the epithelial-to-mesenchymal transition and/or the mesenchymal-to-epithe... |
39812871 | Development of biomaterials for bone tissue engineering based on bile acids. | Diseases and injuries can cause significant bone loss, leading to increased medical expenses, decreased work efficiency, and a decline in quality of life. Bone tissue engineering (BTE) is gaining attention as an alternative to autologous and allogeneic transplantation due to the limited availability of donors. Biomater... |
39812830 | Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink. | Femtosecond lasers represent a novel tool for tattoo removal as sources that can be operated at high power, potentially leading to different removal pathways and products. Consequently, the potential toxicity of its application also needs to be evaluated. In this framework, we present a comparative study of Ti:Sapphire... |
39812806 | Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation. | Atherosclerosis (AS) is a prevalent inflammatory vascular disease characterized by plaque formation, primarily composed of foam cells laden with lipids. Despite lipid-lowering therapies, effective plaque clearance remains challenging due to the overexpression of the CD47 molecule on apoptotic foam cells, inhibiting mac... |
39812739 | A fluorescent sensor based on pentafluoropropanoic acid-functionalized UiO-66-NH<sub>2</sub> for enhanced selectivity and sensitivity of dicloran detection. | A pentafluoropropionic acid-functionalized fluorescent metal-organic framework material (UiO-66-NH<sub>2</sub>-PFPA) is prepared by a simple post-synthetic modification (PSM) strategy for the sensitive and selective detection of dichloran (DCN). The results of fluorescence experiments demonstrate that the sensitivity o... |
39812713 | Excited-State Rotational Dynamics of Amine-Functionalized Terephthalic Acid Derivatives as Linker Models for Metal-Organic Frameworks. | Understanding how structural modifications affect the photophysics of organic linkers is crucial for their integration into metal-organic frameworks (MOFs) for light-driven applications. This study explores the impact of varying the amine functional group position on two terephthalic acid derivatives─linker <b>1</b> an... |
39812661 | An audit on the assessment and management of osteoporosis in a Parkinson's and related diseases clinic in Australia. | <h4>Background</h4>Patients with Parkinson's disease (PD) and atypical parkinsonian syndromes are at increased risk of falls and should be actively screened and treated for osteoporosis. In 2024, the Royal Australian College of General Practitioners (RACGP) revised their practice guidelines for diagnosing and managing ... |
39812524 | Constructing a Polyoxometalate-Based Metal-Organic Framework for Photocatalytic Oxidation of Thioethers to Sulfoxides Utilizing In Situ-Generated Superoxide Radicals. | Developing new photocatalysts for the selective oxidation of thioethers to high-value-added sulfoxides under low-oxygen mild conditions is a promising but challenging strategy. Here, a new polyoxometalate-based metal-organic framework (POMOF), <b>CoBW</b><sub><b>12</b></sub><b>-TPT</b>, was successfully synthesized, wh... |
39812444 | Sodium Ion Diffusion Behavior in Multiple Open/Closed Pore Ratios of Novel β-Cyclodextrin-Derived Hard Carbon Anode Materials. | Plateau-dominated hard carbon with a high rate of performance is challenging to obtain, and the in-depth mechanism of pore structure on the diffusion of sodium ions remains unclear. In this study, a facile liquid-phase molecular reconstruction strategy is proposed to regulate the orientation of the β-cyclodextrin molec... |
39812334 | Dynamic Covalent Sulfur-Selenium Rich Polymers via Inverse Vulcanization for High Refractive Index, High Transmittance, and UV Shielding Materials. | Recent advancements in inverse vulcanization have led to the development of sulfur-rich polymers with diverse applications. However, progress is constrained by the harsh high-temperature reaction conditions, limited applicability, and the generation of hazardous H<sub>2</sub>S gas. This study presents an induced IV met... |
39811986 | Leveraging Optical Anisotropy of the Morpho Butterfly Wing for Quantitative, Stain-Free, and Contact-Free Assessment of Biological Tissue Microstructures. | Changes in the density and organization of fibrous biological tissues often accompany the progression of serious diseases ranging from fibrosis to neurodegenerative diseases, heart disease and cancer. However, challenges in cost, complexity, or precision faced by existing imaging methodologies and materials pose barrie... |
39811958 | Site-Specific for CO<sub>2</sub> Photoreduction with Single-Atom Ni on Strained TiO<sub>2-x</sub> Derived from Bimetallic Metal-Organic Frameworks. | The photocatalytic reduction of CO<sub>2</sub> in water to produce fuels and chemicals is promising while challenging. However, many photocatalysts for accomplishing such challenging task usually suffer from unspecific catalytic active sites and the inefficient charge carrier's separation. Here, a site-specific single-... |
39811922 | Supramolecular Gelation Based on Native Amino Acid Tyrosine and Its Charge-Transfer Complex Formation. | Self-assembly of amino acids and short-peptide derivatives attracted significant curiosity worldwide due to their unique self-assembly process and wide variety of applications. Amino acid is considered one of the important synthons in supramolecular chemistry. Self-assembly processes and applications of unfunctionalize... |
39810092 | Unveiling alfalfa root rot resistance genes through an integrative GWAS and transcriptome study. | <h4>Background</h4>Root rot is a major disease affecting alfalfa (Medicago sativa L.), causing significant yield losses and economic damage. The primary pathogens include Fusarium spp., Rhizoctonia spp., Pythium spp., and Phytophthora spp., with Fusarium being particularly severe. Breeding disease-resistant varieties i... |
39809901 | A synthetic cyclic peptide for promoting antigen presentation and immune activation. | Cyclic peptides are often used as scaffolds for the multivalent presentation of drug molecules due to their structural stability and constrained conformation. We identified a cyclic deca-peptide incorporating lipoamino acids for delivering T helper and B cell epitopes against group A Streptococcus (GAS), eliciting robu... |
39779485 | Leveraging Multivalent Assembly towards High-Temperature Liquid-Phase Phosphorescence. | High-temperature phosphorescence (HTP) materials have attracted considerable attention owing to their expanded application prospects, whereas they still suffer from severe deactivation in polar media, limiting their reliability and utility. Here, we present an efficient multivalent assembly strategy to achieve high-tem... |
39779481 | Covalent Adaptable Poly[2]rotaxane Networks via Dynamic C-N Bond Transalkylation. | Covalent adaptable networks (CANs), a novel class of crosslinked polymers with dynamic covalent bonds, have gained significant attention for combining the durability of thermosets with the reprocessability of thermoplastics, making them promising for emerging applications. Here, we report the first example of poly[2]ro... |
39777931 | Construction of MOF-Derived Vanadium Nitride Decorated Micro/Mesoporous Carbon Nanofibers for Aqueous Zinc-Ion Batteries. | Design and manufacture of cathode materials, with suitable pore structure and high electrical conductivity to matching zinc anode, solving the problem of dissolution and structural degradation of cathode materials for zinc ion batteries (ZIBs), is great significance to the development of ZIBs. Herein, Vanadium Nitride ... |
39777425 | Stimulus-Responsive Organometallic Assemblies Based on Azobenzene-Functionalized Poly-NHC Ligands. | The reversible photoisomerization of azobenzene (AZB) and its derivatives has been applied across various fields. Developing discrete AZB-functionalized organometallic cages is essential for manufacturing functional materials. In this work, we designed and fabricated a series of three-dimensional, hexaazobenzene-termin... |
39776046 | Metal-Organic Framework with Polar Pore Surface Designed for Purification of Both Natural Gas and Ethylene. | The advancement of high-value CH<sub>4</sub> purification technology within the natural gas industry is paramount for industrial processes. Herein, we constructed ZJNU-402, a new porous material characterized by permanent porosity, as an effective adsorbent for separating C<sub>3</sub>H<sub>8</sub>/CH<sub>4</sub> and C... |
39775983 | Piezochromic Luminescence of Pyrene Derivatives Polymorphism Around Excimer Forming Process. | Pyrene aggregates, as classic luminescent materials, are of great interest from a scientific viewpoint owing to the development of optoelectronic materials. In this study, we designed a compound 1,4,5-triphenyl-2-(pyren-1-yl)-4,5-dihydro-1H-imidazole (IM-PY) which was achieved with two crystalline polymorphs (IMPY-G an... |
39753519 | Metal Organic Framework Based on Photoactivated Aggregation-Induced Emission Molecule for Achieving Photoexcitation Regulation. | Ln-MOFs, composed of lanthanide ions and functional organic ligands, are porous materials with tunable structures and unique luminescent properties. However, the interplay between ligand AIE properties and the framework's "antenna effect" on MOF morphology is understudied. Here, Tb-D-Cam-TPTB was synthesized via solvot... |
39749829 | Impact of Structural Subtleties on Chirality Induction and Amplification in Trizinc(II)Porphyrin Trimers. | Herein, we report the precise control of molecular to supramolecular chirality induction at the single-molecule level just upon subtle modification in an achiral 'nano-size' trizinc(II) porphyrin trimer. A slight variation in the projection of the substituent at the periphery of the central porphyrin unit in a porphyri... |
39745478 | Stereospecific Radical Bromination of β-Aryl Alcohols with Thiourea Additives Through A Serendipitous Discovery of A 1,2-Aryl Migration. | The development of new protocols for stereospecific and stereoselective halogenation transformations by mild reaction conditions is a highly desirable research target for the chemical and pharmaceutical industries. Following the straightforward methodology for directly transforming a wide scope of alcohols to alkyl bro... |
39739998 | Magnetic Assisted DNA Logic Gate Nanomachine Based on CRISPR/Cas12a for Recognition of Dual miRNAs. | The anomalous expression of microRNA poses a serious threat to human life and health safety, and serves as an important biomarker for cancer detection. In this study, a novel magnetic-assisted DNA logic gate nanomachine triggered by miRNA-21 and miRNA-155 was designed based on the trans-cleavage activity of CRISPR/Cas1... |
39718019 | Mechanisms of alignment of lamellar-forming block copolymer under shear flow. | The potential applications of block copolymer thin films, utilising their self-assembly capabilities, are enhanced when achieving long-range ordering. In this study we explain the experimental alignment of lamellae under shear flow findings [S. Pujari <i>et al. Soft Matter</i>, 2012, <b>8</b>, 5258] and classify the al... |
39711261 | Molecular insights into kinetic stabilization of amorphous solid dispersion of pharmaceuticals. | Poor aqueous solubility of crystalline active pharmaceutical ingredients (APIs) restricts their bioavailability. Amorphous solid dispersions with biocompatible polymer excipients offer a solution to overcome this problem, potentially enabling a broader use of many drug candidate molecules. This work addresses various a... |
39704551 | Bioactive zeolitic imidazolate framework nanoconjugates as synergistic drug delivery agents for cancer nanotherapeutics. | The increasing effective, detectable, and targeted anticancer systems are driven by the growing cancer incidence and the side effects of current drugs. Natural products like saponin and apigenin have emerged as valuable compounds for precise treatment. Recent advancements in bioactive metal-organic frameworks (MOFs) ha... |
39704239 | A multi-scale circuit model bridges molecular modeling and experimental measurements of conductive metal-organic framework supercapacitors. | A multi-scale model is crucial for combining experiments and simulations to reveal the energy storage mechanism. As novel electrode materials, conductive metal-organic frameworks (c-MOFs) provide an ideal platform for understanding the energy storage process in supercapacitors. However, the prevailing circuit models la... |
39704002 | Protein-polyelectrolyte complexation: effects of sterically repulsive groups, macromolecular architecture and hierarchical assembly. | Self-assembly of proteins and polyelectrolytes in aqueous solutions is a promising approach for the development of advanced biotherapeutics and engineering efficient biotechnological processes. Synthetic polyions containing sterically repulsive ethylene oxide moieties are especially attractive as protein modifying agen... |
39688920 | Supramolecular adhesives inspired from adhesive proteins and nucleic acids: molecular design, properties, and applications. | Bioinspired supramolecular adhesives have been recently emerging as novel functional materials, which have shown a wide range of applications in wearable sensors and tissue engineering such as tissue adhesives and wound dressings. In this review, we summarize and discuss two main types of biologically inspired supramol... |
39653498 | Mitochondrial A<sub>3</sub> Adenosine Receptor as a Mechanism for the Protective Effects of A<sub>3</sub>AR Agonists on Chemotherapy-Induced Neuropathic Pain. | Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioe... |
39635833 | Emissive triphenylamine functionalised 1,8-naphthalimide and naphthalene diimide fluorophores: aggregation, computation and biological studies. | Four new aromatic imides bearing triphenylamino (TPA) moieties are reported each of which differ by the number and/or positional arrangements of the TPA units. Compounds 1-3 are 1,8-naphthalimides (naps) that contain <i>N</i>,<i>N</i>'-diphenyl-[1,1'-biphenyl]-4-amino (TPA-Ph) groups appended to the <i>N</i>-termini of... |
39618241 | Facile synthesis and anion binding properties of a preorganized macrocyclic receptor. | Herein, we report a novel Schiff base macrocyclic receptor (MR). The structure of MR was characterized by NMR, UV-vis and fluorescence spectroscopy, revealing that it was a rigid and preorganized planar π-conjugated fluorescent macrocycle. Furthermore, MR showed effective binding properties with tetrabutylammonium hali... |
39600194 | L-Amino acid ester as a biomimetic reducing agent for the reduction of unsaturated CC bonds. | The first example of an efficient protocol for the reduction of disubstituted methyleneindolinones, isoindigos and tetrasubstituted olefins for the synthesis of 3-substituted 2-oxindoles, dihydroisoindigos and tetrasubstituted ethane derivatives using an L-amino acid ester as an attractive biomimetic reducing agent has... |
39431936 | Calculated and structural analyses of self-assembly formed by [7]thiaheterohelicene-2,13-carboxaldehyde molecules on Au(111). | Recently, the electronic and structural properties of large self-assembled domains of [7]thiaheterohelicene-2,13-carboxaldehyde helicene ([7]TH-dial) molecules on Au(111), Cu(001), and NiAl(110) metal surfaces have been characterized by scanning tunneling microscopy (STM). Several distinct areas of the self-assembled s... |
40838107 | A review of 3D bioprinting for organoids. | Current two-dimensional (2D) cell models for effective drug screening suffer from significant limitations imposed by the lack of realism in the physiological environment. Three-dimensional (3D) organoids models hold immense potential in mimicking the key functions of human organs by overcoming the limitations of tradit... |
40093842 | Cold-Plasma-Driven Ammonia Synthesis over Porous Silica: The Role of the Morphology. | Nonthermal plasma (NTP) has opened unexplored routes for small-scale, decentralized ammonia production. However, understanding the ammonia formation pathways when employing NTP-driven processes is challenging due to the complex nature of the process. In this work, we report the effects of the morphology and textural pr... |
39944884 | Diverse single-stranded nucleic acid binding proteins enable both stable protection and rapid exchange required for biological function. | Single-stranded nucleic acid (ssNA) binding proteins must both stably protect ssNA transiently exposed during replication and other NA transactions, and also rapidly reorganize and dissociate to allow further NA processing. How these seemingly opposing functions can coexist has been recently elucidated by optical tweez... |
39927393 | Crystal structures of zinc(II) coordination complexes with iso-quinoline <i>N</i>-oxide. | The reaction of one equivalent of zinc(II) halide salts with two equivalents of iso-quinoline <i>N</i>-oxide (iQNO; C<sub>9</sub>H<sub>7</sub>NO) in methanol yields compounds of the general formula [Zn<i>X</i> <sub>2</sub>(iQNO)<sub>2</sub>], with <i>X</i> = Cl<sup>-</sup> (<b>I</b>), Br<sup>-</sup> (<b>II</b>) and I<s... |
39927384 | Syntheses, crystal structures, Hirshfeld surface analyses and crystal voids of 1-(4-bromo-phen-yl)-2,2-di-chloro-ethan-1-one and 2,2-di-bromo-1-(<i>p</i>-tol-yl)ethan-1-one. | The asymmetric units of the compounds, C<sub>8</sub>H<sub>5</sub>BrCl<sub>2</sub>O (I), and C<sub>9</sub>H<sub>8</sub>Br<sub>2</sub>O (II), contain two and one crystallographically independent mol-ecules, respectively. In compound (I), the planar rings are oriented at a dihedral angle of 13.23 (8)°. In crystals of both... |
39914962 | Advanced targeted curcumin delivery using biodegradable hierarchical microspheres with calcium pectinate matrix and hyaluronic acid moieties for enhancing colitis amelioration. | Oral targeted delivery systems for food bioactive compounds have attracted considerable attention for improving the efficiency of nutritional interventions. In this study, a hierarchical curcumin carrier with sequence-targeting capability was fabricated to mitigate colitis through a convenient and environmentally frien... |
39906289 | Biomedical Applications of Metal-Organic Frameworks Revisited. | Metal-organic frameworks (MOFs) have been shown to be great alternatives to traditional porous materials in various chemical applications, and they have been very widely studied for biomedical applications in the past decade specifically for drug storage. After our review published in 2011 [Keskin and Kızılel, <i>Ind</... |
39896796 | Fatal case of sepsis caused by <i>Raoultella ornithinolytica</i>: A rare opportunistic pathogen. | We present a rare case of sepsis caused by <i>Raoultella ornithinolytica</i>, a gram-negative, encapsulated bacterium. The patient, a 46-year-old male, was admitted to the intensive care unit with severe diabetic ketoacidosis, acute renal failure, and sepsis. Despite aggressive management, including continuous renal re... |
39895742 | Comprehensive Physicochemical Characterization and in Vitro Human Cell Culture Studies of an Innovative Biocompatible and Biodegradable Silk-Derived Protein Hydrolysate, SDP-4. | SDP-4 is a soluble silk fibroin-derived protein hydrolysate extracted from the <i>Bombyx mori</i> silkworm cocoon and is a novel first-in-class biopolymer that is biodegradable, biocompatible, and shown to have regenerative properties. SDP-4 is currently used as a commercial wetting agent in topical eye drops, but it h... |
39895718 | Intracellular Biomacromolecule Delivery by Stimuli-Responsive Protein Vesicles Loaded by Hydrophobic Ion Pairing. | Proteins can perform ideal therapeutic functions. However, their large size and significant surface hydrophilicity and charge prohibit them from reaching intracellular targets. These chemical features also render them poorly encapsulated by nanoparticles used for intracellular delivery. In this work, a novel combinatio... |
39895699 | Curcumin-Loaded ZIF-8 Nanomaterials: Exploring Drug Loading Efficiency and Biomedical Performance. | Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by its rapid degradation, limited bioavailability, and poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface are... |
39886349 | Development of small-molecule fluorescent probes targeting neutrophils <i>via N</i>-formyl peptide receptors. | <i>N</i>-Formyl peptide receptors (FPRs) are membrane receptors that are abundantly expressed in innate immune cells, including neutrophils and platelets, demonstrating potential new targets for immune system regulation and the treatment of inflammatory conditions. We report here the development and bio-physical valida... |
39877652 | Innovative epitopes in <i>Staphylococcal</i> Protein-A an immuno-informatics approach to combat MDR-MRSA infections. | <h4>Background</h4>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) poses a significant challenge in clinical environments due to its resistance to standard antibiotics. <i>Staphylococcal</i> Protein A (SpA), a crucial virulence factor of MRSA, undermines host immune responses, making it an attractive target f... |
39877362 | Interactions of human milk oligosaccharides with the immune system. | Human milk oligosaccharides (HMOs) are abundant, diverse and complex sugars present in human breast milk. HMOs are well-characterized barriers to microbial infection and by modulating the human microbiome they are also thought to be nutritionally beneficial to the infant. The structural variety of over 200 HMOs, includ... |
39877356 | A c-type lectin <i>HcLec1</i> with dual function of immunology and mineralization from the freshwater oyster (<i>Hyriopsis cumingii</i> Lea). | <h4>Background</h4>Shell and pearl formation in bivalves is a sophisticated biomineralization process that encompasses immunological and mineralization aspects, particularly during shell repair and the initial stages of pearl cultivation when a nucleus is inserted. Here, we describe a novel C-type lectin, HcLec1, isola... |
39877351 | Neutralizing antibody landscape of the non-polio Enteroviruses and future strategy. | The non-polio Enteroviruses (NPEVs), consist of enteroviruses, coxsackieviruses, echoviruses, and rhinoviruses, are causative agents for a wide variety of diseases, ranging from common cold to encephalitis and acute flaccid paralysis (AFP). In recent years, several NPEVs have become serious public health threats, inclu... |
39861889 | Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research. | Coronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse models, and others. Mor... |
39861754 | Comparison of Two Synthesis Methods for 3D PLA-Ibuprofen Nanofibrillar Scaffolds. | <h4>Objectives</h4>This study aimed to synthesize polylactic acid (PLA) nanofibrillar scaffolds loaded with ibuprofen (IBU) using electrospinning (ES) and air-jet spinning (AJS). The scaffolds were evaluated for their physicochemical properties, drug release profiles, and biocompatibility to assess their potential for ... |
39861752 | Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives. | Monogenic disorders are a group of human diseases caused by mutations in single genes. While some disease-altering treatments offer relief and slow the progression of certain conditions, the majority of monogenic disorders still lack effective therapies. In recent years, gene therapy has appeared as a promising approac... |
39861750 | Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach. | The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, s... |
39861568 | Lyophilized and Oven-Dried <i>Manilkara zapota</i> Extracts: Characterization and <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Analyses. | In this work, extracts from the pulp, peel, and seed of <i>Manilkara zapota</i> were obtained via lyophilization and oven drying. Bromatological analyses were performed to investigate variabilities in the nutritional content of fruits after nine post-harvest days. The phytochemical content of fruits was assessed by gas... |
39861565 | Application of Biochar-Immobilized <i>Bacillus megaterium</i> for Enhancing Phosphorus Uptake and Growth in Rice. | Phosphorus (P) is an essential nutrient for rice growth, and the presence of phosphate-solubilizing bacteria (PSB) is an effective means to increase soil P content. However, the direct application of PSB may have minimal significance due to their low survival in soil. Biochar serves as a carrier that enhances microbial... |
39860174 | Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential. | Malaria, caused by <i>Plasmodium</i> species and transmitted by <i>Anopheles</i> mosquitoes, continues to pose a significant global health threat. Pipecolisporin, a cyclic hexapeptide isolated from <i>Nigrospora oryzae</i>, has emerged as a promising antimalarial candidate due to its potent biological activity and stab... |
39860179 | NMR and MD Simulations of Non-Ionic Surfactants. | Non-ionic surfactants are an important solvent in the field of green chemistry with tremendous application potential. Understanding their phase properties in bulk or in confined environments is of high commercial value. In recent years, the combination of molecular dynamics (MD) simulations with multinuclear solid-stat... |
39860036 | Alzheimer's Disease and <i>Porphyromonas gingivalis</i>: Exploring the Links. | Recent research highlights compelling links between oral health, particularly periodontitis, and systemic diseases, including Alzheimer's disease (AD). Although the biological mechanisms underlying these associations remain unclear, the role of periodontal pathogens, particularly <i>Porphyromonas gingivalis</i>, has ga... |
39859832 | Study on Synergistically Improving Corrosion Resistance of Microarc Oxidation Coating on Magnesium Alloy by Loading of Sodium Tungstate and Silane Treatment. | Sodium tungstate (Na<sub>2</sub>WO<sub>4</sub>) was filled into the micropores and onto the surface of a magnesium alloy microarc oxidation (MAO) coating by means of vacuum impregnation. Subsequently, the coating was sealed through silane treatment to synergistically boost its corrosion resistance. The phase compositio... |
39859827 | Influence of Different Solvents on the Mechanical Properties of Electrospun Scaffolds. | This article investigates the influence of different solvents on the mechanical properties of biocompatible and biodegradable polycaprolactone (PCL) scaffolds. During the research, using electrospinning technology, 27 samples of polycaprolactone nanofibers exposed to different solvents were produced. A tensile test was... |
39859823 | Conventional Thermoset Composites and Their Sustainable Alternatives with Vitrimer Matrix-Waste Management/Recycling Options with Focus on Carbon Fiber Reinforced Epoxy Resin Composites. | Carbon-fiber-reinforced polymers (CFRPs) with epoxy matrices are widely applied in high-performance structural applications and represent one of the biggest classes of materials with urgent need for end-of-life management. Available waste management methodologies for conventional thermoset composites with a focus on CF... |
39859814 | Bilayer TiO<sub>2</sub>/Mo-BiVO<sub>4</sub> Photoelectrocatalysts for Ibuprofen Degradation. | Heterojunction formation between BiVO<sub>4</sub> nanomaterials and benchmark semiconductor photocatalysts has been keenly pursued as a promising approach to improve charge transport and charge separation via interfacial electron transfer for the photoelectrocatalytic degradation of recalcitrant pharmaceutical pollutan... |
39858514 | Acral Melanoma: A Review of Its Pathogenesis, Progression, and Management. | Acral melanoma is a distinct subtype of cutaneous malignant melanoma that uniquely occurs on ultraviolet (UV)-shielded, glabrous skin of the palms, soles, and nail beds. While acral melanoma only accounts for 2-3% of all melanomas, it represents the most common subtype among darker-skinned, non-Caucasian individuals. U... |
39857778 | Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway. | <h4>Background</h4>Ezetimibe is used to treat cardiovascular disease as it blocks the sterol transporter Niemann-Pick C1-Like 1 (NPC1CL1) protein. However, recent evidence indicates that Ezetimibe inhibits several cancers indirectly by reducing circulating cholesterol or via specific signalling pathways.<h4>Methods and... |
39857559 | Comparison Between Water Aerobics and Deep-Water Running on Middle-Aged Adults' Anthropometric, Hemodynamic and Functional Outcomes. | <h4>Background</h4>Head-out aquatic training, using modalities such as water-aerobics/hydrogymnastics (HYD) and deep-water running (DWR), has been effective in improving the physical, metabolic and cognitive health of middle-aged adults. However, direct comparisons between these modalities are lacking.<h4>Aim</h4>The a... |
39857301 | NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics. | The prevalence of osteoarthritis (OA) notably surges with age and weight gain. The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. Thus, understanding OA's pathogenesis and devising effective therapies is crucial. It is generally recognized that inflammatio... |
39856906 | Impact of Ultrasonic-Assisted Preparation of Water Caltrop Starch-Lipid Complex: Structural and Physicochemical Properties. | This study investigates the effect of ultrasonic-assisted preparation on the structural and physicochemical properties of water caltrop starch-palmitic acid complexes as a function of ultrasound intensity and treatment time. All samples exhibited the characteristic birefringence of starch-lipid complexes under the pola... |
39852581 | Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions. | Oral diseases such as dental caries, periodontitis, and oral cancer are prevalent and present significant challenges to global public health. Although these diseases are typically treated through procedures like dental preparation and resin filling, scaling and root planning, or surgical excision, these interventions a... |
39852580 | Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases. | Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation to avoid adverse side effects. Recent advancements in biodegradable and stimuli-responsive nanomaterials have opened new avenues for targeted drug delivery systems capabl... |
39850125 | Towards high atom economy in whole-cell redox biocatalysis: up-scaling light-driven cyanobacterial ene-reductions in a flat panel photobioreactor. | Light-driven biotransformations in recombinant cyanobacteria benefit from the atom-efficient regeneration of reaction equivalents like NADPH from water and light by oxygenic photosynthesis. The self-shading of photosynthetic cells throughout the reaction volume, along with the need for extended light paths, limits adeq... |
39834894 | Cu(OTf)<sub>2</sub>-catalyzed multicomponent reactions. | This review reports the achievements in copper(II) triflate-catalyzed processes concerning the multicomponent reactions, applied to the synthesis of acyclic and cyclic compounds. In particular, for the heteropolycyclic systems mechanistic insights were outlined as well as cycloaddition and aza-Diels-Alder reactions wer... |
39823031 | Comparative investigation on the adsorption behavior of bromate in aqueous solutions using Zn/Ni/Al-LDH and Ni/Al-LDH: optimization, equilibrium analysis, and mechanistic insights. | The presence of bromate in water poses a significant health risk. In order to effectively eliminate bromate from water, this study synthesized a series of ternary Zn-Ni-Al layered double hydroxides with varying Zn/Ni/Al atomic ratios using a co-precipitation method. The adsorbents were characterized using various techn... |
39818379 | In situ growth of ZIF-8 nanoparticles on pure chitosan nanofibrous membranes for efficient antimicrobial wound dressings. | Bacterial infections and excessive accumulation of wound exudates remain the main obstacles and clinical challenges to the healing of chronic cutaneous wounds. Conventional dressings are commonly used medical materials for acute wound care, but they do not possess the bacterial infection resistance required for chronic... |
39818362 | Stabilizing effect of HP-β-CD on infliximab in liquid formulations and a solid formulation produced by electrospinning. | The development of stable biopharmaceutical formulations, such as monoclonal antibodies, poses a great challenge in the pharmaceutical industry. This study investigated the stabilizing effect of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in liquid and solid formulations of infliximab during processing and storage. The so... |
39811801 | Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3. | Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. Here, we explored the ameliorati... |
39810855 | Recent Advances in Self-Powered Sensors Based on Ionic Hydrogels. | After years of research and development, flexible sensors are gradually evolving from the traditional "electronic" paradigm to the "ionic" dimension. Smart flexible sensors derived from the concept of ion transport are gradually emerging in the flexible electronics. In particular, ionic hydrogels have increasingly beco... |
39810543 | Dual Activation Modes Enable Bifunctional Catalysis of Aldol Reactions by Flexible Dihydrazides. | Hydrazides are known to catalyze reactions of α,β-unsaturated aldehydes via transient iminium formation. The iminium intermediate displays enhanced electrophilicity, which facilitates conjugate additions and cycloadditions. We observed that a hydrazide embedded in a seven-membered ring catalyzes homoaldol condensation ... |
39810461 | Symmetric Diblock Copolymers Form Versatile and Switchable Ultrasmall Nanoparticles. | Block copolymers (BCPs) can form nanoparticles having different morphologies that can be used as photonic nanocrystals and are a platform for drug delivery, sensors, and catalysis. In particular, BCP nanoparticles having disk-like shape have been recently discovered. Such nanodisks can be used as the next-generation an... |
39810388 | Peptidisc-Assisted Hydrophobic Clustering Toward the Production of Multimeric and Multispecific Nanobody Proteins. | Multimerization is a powerful engineering strategy for enhancing protein structural stability, diversity and functional performance. Typical methods for clustering proteins include tandem linking, fusion to self-assembly domains and cross-linking. Here we present a novel approach that leverages the Peptidisc membrane m... |
39810294 | Modular Construction of Multivariate Metal-Organic Frameworks for Luminescent Sensing. | Metal-organic frameworks (MOFs) have played a pivotal role as rapid and effective luminescent sensing materials. Numerous MOFs with diverse characteristics have been meticulously designed for target analytes. Previous studies have highlighted the factors of spectral characteristics, energy levels, interaction forces, a... |
39810167 | Microalgae-based bioremediation of refractory pollutants: an approach towards environmental sustainability. | Extensive anthropogenic activity has led to the accumulation of organic and inorganic contaminants in diverse ecosystems, which presents significant challenges for the environment and its inhabitants. Utilizing microalgae as a bioremediation tool can present a potential solution to these challenges. Microalgae have gai... |
39810075 | Development of a TSR-based method for understanding structural relationships of cofactors and local environments in photosystem I. | <h4>Background</h4>All chemical forms of energy and oxygen on Earth are generated via photosynthesis where light energy is converted into redox energy by two photosystems (PS I and PS II). There is an increasing number of PS I 3D structures deposited in the Protein Data Bank (PDB). The Triangular Spatial Relationship (... |
39809942 | Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3. | Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca<sup>2+</sup>-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosomal dominant neurodevelopmental disorders caused by ga... |
39809933 | Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning. | Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision Nanocarrier Identification (SCP-Nano), an integrated experimental and deep learning pipeline to comprehensive... |
39809811 | Human interpretable structure-property relationships in chemistry using explainable machine learning and large language models. | Explainable Artificial Intelligence (XAI) is an emerging field in AI that aims to address the opaque nature of machine learning models. Furthermore, it has been shown that XAI can be used to extract input-output relationships, making them a useful tool in chemistry to understand structure-property relationships. Howeve... |
39809787 | Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE. | Helicobacter pylori (H. pylori) infection is a well-established risk factor for gastric cancer, primarily due to its virulence factor, cytotoxin-associated gene A (CagA). Although PD-L1/PD-1-mediated immune evasion is critical in cancer development, the impact of CagA on PD-L1 regulation remains unclear. This study rev... |
39809760 | White light-emitting electrochemical cells based on metal-free TADF emitters. | The attainment of white emission from a light-emitting electrochemical cell (LEC) is important, since it enables illumination and facile color conversion from devices that can be cost-efficient and sustainable. However, a drawback with current white LECs is that they either employ non-sustainable metals as an emitter c... |
39809740 | Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species. | Human gut Bacteroides and Parabacteroides species play crucial roles in human health and are known for their capacity to utilize diverse polysaccharides. Understanding how these bacteria utilize medicinal polysaccharides is foundational for developing polysaccharides-based prebiotics and drugs. Here, we systematically ... |
39809464 | An Adsorbent for Efficient and Rapid Gold Recovery from Solution: Adsorption Properties and Mechanisms. | Adsorption is an efficient and highly selective method for gold recovery. Introducing rich N/S organic groups to combine with metal-organic frameworks (MOFs) as adsorbents is regarded as a practical and efficient approach to enhance gold recovery. Herein, a MOF (zirconium isothiocyanatobenzenedicarboxylate MOF, UiO-66-... |
39809457 | Water Activity as an Indicator for Antibody Storage Stability in Lyophilized Formulations. | Lyophilization remains a key method for preserving sensitive biopharmaceuticals such as monoclonal antibodies. Traditionally, stabilization mechanisms have been explained by vitrification, which minimizes molecular mobility in the lyophilized cake, and water replacement, which restores molecular interactions disrupted ... |
39808696 | Designing Chiral Organometallic Nanosheets with Room-Temperature Multiferroicity and Topological Nodes. | Two-dimensional (2D) room-temperature chiral multiferroic and magnetic topological materials are essential for constructing functional spintronic devices, yet their number is extremely limited. Here, by using the chiral and polar HPP (HPP = 4-(3-hydroxypyridin-4-yl)pyridin-3-ol) as an organic linker and transition meta... |
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