id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
40396656 | Legume-specific recruitment of rhizobia by hyphae of arbuscular mycorrhizal fungi. | The legume-rhizobia symbiosis possesses great potential for sustainable agriculture because of its ability to fix atmospheric nitrogen, reducing crop dependence on nitrogen fertilizers. Rhizobia recognize the host legume through flavonoids released by the roots. These signals are detected by bacteria typically over a f... |
40384205 | Causes of death in the Emergency Department: a retrospective monocentric study. | The Emergency Department (ED) serves as a critical entry point for patients with life-threatening conditions, yet mortality within this setting remains a significant clinical and epidemiological concern. This retrospective monocentric study investigates the primary causes of death in the ED of Emergency Municipal Hospi... |
40384192 | COVID-19 - multisystem disease. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), caused a global public health crisis, with a significant impact on multiple body systems. This virus, a member of the Coronaviridae family, shows ~80% genomic similarity to SARS-CoV and ~50% geno... |
40366866 | Telomere-to-telomere genome of common bean (Phaseolus vulgaris L., YP4). | <h4>Background</h4>Common bean is a significant grain legume in human diets. However, the lack of a complete reference genome for common beans has hindered efforts to improve agronomic cultivars.<h4>Findings</h4>Herein, we present the first telomere-to-telomere (T2T) genome assembly of common bean (Phaseolus vulgaris L... |
40350302 | Dawn of photoredox catalysis. | Photoredox catalysis, which facilitates organic transformations under visible-light irradiation, including sunlight, has garnered considerable attention as a cornerstone of green chemistry. Since the early days of this field around 2010, the author's group has made substantial contributions to its advancement. This rev... |
40331850 | The associations between skeletal muscle mass to visceral fat area ratio (SVR) with bone mineral density (BMD) and 10-year probability of fracture risk in Chinese patients with type 2 diabetes mellitus (T2DM): a cross-sectional study. | <h4>Introduction</h4>Patients with type 2 diabetes mellitus (T2DM) have a higher risk of fracture, higher visceral fat, and lower muscle mass. The combined effect of skeletal muscle mass and visceral fat area [skeletal muscle mass to visceral fat area ratio (SVR)] on bone mineral density (BMD) and fracture risk in T2DM... |
40329728 | Molecularly Imprinted Polymers (MIPs): A Multifaceted Tool in Modern Analysis. | Molecularly Imprinted Polymers (MIPs) are specialized synthetic materials with custom-designed molecular recognition properties. They are created by polymerizing monomers around a template molecule. MIPs play a crucial role in various analytical fields, including drug detection in biological samples, protein and peptid... |
40325821 | Identification of Novel Selective Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists. | <h4>Aims</h4>We aimed to synthesize small-molecule compounds by modifying the chemical structure of GSK101 and screening for novel TRPV4 agonists with high specificity and selective sensory response.<h4>Background</h4>GSK1016790A (GSK101) effectively activates Transient Receptor Potential Vanilloid 4 (TRPV4) and simult... |
40309523 | Assessment of serum laminin and hyaluronic acid as markers of hepatic fibrosis in patients with chronic Hepatitis B. | <h4>Background</h4>Hepatitis B virus (HBV) is a major cause of chronic liver disease worldwide. Fibrosis of hepatic parenchyma has been reported as a common pathway to complications of chronic liver disease. There is a need to monitor fibrosis in these patients to abort or delay disease progression following treatment.... |
40304913 | ATR-Infrared Spectroscopy and Acoustic Sensing in Characterization of Blood and Pancreatic Ductal Adenocarcinoma-Derived Extracellular Vesicles. | Extracellular vesicles (EVs) are phospholipid bilayer-enclosed nanoparticles secreted by most cells into the biofluids. They have an important role in intercellular communication by carrying bioactive components (e.g., lipids, proteins, nucleic acids, and other metabolites) and reflecting the biochemical and metabolic ... |
40304914 | Floating Films of Biological Importance at the Liquid-Gas Interface: Langmuir Monolayer Approach. | Langmuir films are monolayers of water-insoluble molecules formed on aqueous subphases due to the forces of self-assembly. The increased interest in Langmuir monolayers is primarily related to their use as models of biological membranes. The possibility of studying the incorporation and behavior of bioactive compounds ... |
40304912 | Biophysical Profiling of Protein Corona on Red Blood Cell-Derived Extracellular Vesicles (REVs): Linear Dichroism and Microfluidic Resistive Pulse Sensing Separate Surface Clearing from Vesicle Disruption. | Extracellular vesicles (EVs) have attracted significant scientific attention due to their critical functions in intercellular communication and their possible uses in diverse fields such as immunology, therapeutics, reproductive biology, biotechnology, and medicine. EVs are engulfed in a layer of proteins, also known a... |
40291948 | Mitochondria-Plasma Membrane Contact Sites: Emerging Regulators of Mitochondrial Form and Function. | Sites of close apposition between organelles, known as membrane contact sites (MCSs), are critical regulators of organelle function. Mitochondria form elaborate reticular networks that perform essential metabolic and signaling functions. Many mitochondrial functions are regulated by MCSs formed between mitochondria and... |
40289987 | Techniques and Strategies for Engineering Vaccine Adjuvants: A Comprehensive Review. | Vaccines are biological products used to prevent diseases and ailments caused by viruses, bacteria, and fungi. Vaccine adjuvants increase the potency of the vaccine. The vaccine adjuvants like gold nanoparticle, silver nanoparticle, Lentinan-calcium carbonate microsphere, Aluminium nano metal-organic framework, Poly[di... |
40289980 | Transformative Paths: Preclinical Drug Formulation and Delivery Approaches in Development. | This comprehensive review explores the multifaceted landscape of preclinical drug development, encompassing crucial stages, regulatory intricacies, Investigational New Drug (IND) submissions, and innovative formulation strategies. Delving into preclinical studies, the review underscores the importance of pharmacokineti... |
40270096 | Drug Delivery System for Cancer Immunotherapy: Potential Roles, Challenge and Recent Advances. | Immunotherapy has emerged as a pivotal advancement in oncological therapeutics, representing a paradigm shift from conventional treatment modalities including surgery, radiotherapy, and chemotherapy. This innovative approach demonstrates considerable clinical potential through its capacity to enhance systemic anti-tumo... |
40264328 | Alzheimer's Disease and Polymeric Nanocarriers: Synergistic Advances in Targeted Drug Delivery. | <h4>Introduction</h4>Alzheimer's disease (AD) is a prominent neurodegenerative ailment characterized by the constraints of conventional therapies stemming from insufficient medication transport to the brain. This review examines the function of polymeric nanocarriers (PNCs) in improving therapeutic efficacy for Alzheim... |
40259589 | Structural Investigation and Hirshfeld Surface Analysis of 2-6-Dimethoxy-4-((2-Nitrophenylimin)Methyl) Phenol. | <h4>Introduction</h4>The reaction between 4-hydroxy-3,5-dimethoxyenzaldehyde and 2-nitroaniline has been discovered, and the final product has been identified such as 2-6-dimethoxy- 4-((2-nitrophenylimin)methyl)phenol (C1).<h4>Materials and methods</h4>X-ray diffraction examination per-formed on a single crystal provid... |
40247696 | Heat-induced stress modulates cell surface glycans and membrane lipids of coral symbionts. | The susceptibility of corals to environmental stress is determined by complex interactions between host genetic variation and the Symbiodiniaceae family community. We exposed genotypes of Montipora capitata hosting primarily Cladocopium or Durusdinium symbionts to ambient conditions and an 8-day heat stress. Symbionts'... |
40237061 | Photodynamic and Photothermal Therapies using Nanotechnology Approach in Alzheimer's Disease. | Alzheimer's disease is a neurodegenerative disease that impairs cognitive function. The incidence of Alzheimer's disease increases with the increase in the elderly population. Although the clear pathogenesis of Alzheimer's disease is not yet known, the formation of amyloid plaques and tau fibrils, diminished acetylchol... |
40236742 | Neural personal information and its legal protection: evidence from China. | The rapid advancements in neuroscience highlight the pressing need to safeguard neural personal information (NPI). China has achieved significant progress in brain-computer interface technology and its clinical applications. Considering the intrinsic vulnerability of NPI and the paucity of legal scrutiny concerning NPI... |
40231498 | <i>In-Situ</i> Synthesis of Silver Nanoparticle within Self-Assembling Ultrashort Peptide Hydrogel as Antibacterial with Wound Healing Properties. | <h4>Introduction/objectives</h4>Silver nanoparticles (AgNPs) are promising antimicrobial agents, but their synthesis often involves toxic reducing agents. To address this, we developed a green synthesis methodology employing an in-situ approach for synthesizing AgNPs within self- -assembled ultrashort peptide hydrogels... |
40203456 | Analysis of apoptosis levels and MMP7 gene expression in ovaries of postpartum female rabbits after long-term use of LHRH-A3. | Luteinizing hormone-releasing hormone A3 (LHRH-A3), a reproductive hormone analog, is widely used to stimulate ovulation in female rabbits. However, the long-term impact of sustained LHRH-A3 administration on the reproductive system, particularly ovarian health, remains unclear. In this study, we compared apoptosis lev... |
40181867 | Trabecular Bone Score in Asian-Indian Post-menopausal Women Across the Spectrum of Hyperglycaemia: Insights from a Cross-Sectional Study. | <h4>Introduction</h4>Type 2 diabetes mellitus (T2DM) increases the risk of fragility fractures, despite the fact that areal bone mineral density (aBMD) is either increased or normal compared to healthy non-diabetic subjects. Hence, the trabecular bone score (TBS) is under investigation in this patient cohort as an alte... |
40181857 | Hip Structural Analysis and Bone Strain Index in Clinical Practice: Their Utility Beyond BMD. | Previous studies have demonstrated that in certain medical conditions, fragility fractures tend to occur even at bone mineral density (BMD) levels that are in the nonosteoporotic range. This warrants the assessment of other factors beyond BMD that might confer an increased propensity to fracture. Hip structural analysi... |
40175879 | Triggerless Bio-Orthogonal Proximity-Induced PNA Ligation Using 2,5-Dioxopentanyl (DOP) Functionality. | Peptide nucleic acids (PNAs) are emerging tools in the construction of nanostructures possessing self-assembly properties similar to those of DNA but featuring enhanced stability and chemical flexibility. Templated-ligation approaches can be exploited to stabilize the formed nanoproducts, with bio-orthogonal methods pr... |
40175876 | Modification of DNA Nanostructures with Functional Peptides Through Copper-Free Click Chemistry. | The provided protocol outlines a method for synthesizing a peptide-modified three-arm DNA nanostructure. The protocol details the functionalization of three partially complementary amino-modified single-stranded DNA molecules with azide-modified peptide, denoted "PeB," using copper-free click chemistry. This PeB peptid... |
40175869 | Surface-Assisted Assembly of DNA Origami Lattices on Silicon Wafers. | During the last decade, the DNA origami technique has solidified its position as one of the most versatile methods for the fabrication of nanoscale structures, which can be further utilized as templates for a variety of devices and materials. The method has been utilized in many fields such as nanotechnology, photonics... |
40175867 | Topogami: Catenating DNA Origami. | DNA origami is a powerful tool for designing and building functional nanoscale machines. There are practical limitations on the size of a single origami meaning that methods to combine multiple DNA origamis into single functional units would be useful. Catenation of DNA origami structures would provide arguably the mos... |
40175863 | Synthesis and Characterization of DNA Nanostructures and Their Cellular Uptake. | The nature of DNA allows building highly predictable nanostructures that have been applied in a wide range of areas like chemical sensing, material science, molecular data storage, and nanoelectronics. In the field of nanomedicine, DNA nanostructures proved a useful tool for diagnostic and therapeutic purposes. This ch... |
40175104 | Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous. | Co-amorphous materials have gained special attention in the pharmaceutical field due to their high potential to enhance the oral bioavailability of poorly aqueous soluble drugs. In co-amorphous studies, few reports have examined the physical properties and molecular states of different active pharmaceutical ingredients... |
40164158 | Factors Affecting Pathological Amyloid Protein Transformation: From Post-Translational Modifications to Chaperones. | The review discusses the influence of various factors (e.g., post-translational modifications and chaperones) on the pathological transformation of amyloidogenic proteins involved in the onset and development of neurodegenerative diseases (Alzheimer's and Parkinson's diseases) and spongiform encephalopathies of various... |
40162197 | The Cost-Effectiveness of Tenofovir Alafenamide for Chronic Hepatitis B Virus in Taiwan. | <b>Background.</b> Chronic hepatitis B (CHB) is a lifelong disease requiring long-term or indefinite therapy, resulting in substantial economic burden. Thus, careful consideration must be used in the selection of therapies. <b>Aim.</b> This analysis assessed the cost-effectiveness of tenofovir alafenamide (TAF) compare... |
40143399 | Advances in Parenteral Nanocarriers and Delivery Devices: A Comprehensive Review. | The field of drug delivery has witnessed significant advancements with the emergence of nanocarriers and advanced delivery devices for parenteral administration. Nanocarriers, a prominent topic in drug delivery, are introduced with an emphasis on their significance and diverse applications A critical analysis compares ... |
40128483 | Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging. | Among the many changes associated with aging, inflammation in the central nervous system (CNS) and throughout the body likely contributes to the constellation of health-related maladies associated with aging. Genetics, lifestyle factors, and environmental experiences shape the trajectory of aging-associated inflammatio... |
40114579 | Nano-healing: Exploring the Therapeutic Potentials of Nanomedicine for CNS Disorders. | <h4>Introduction</h4>Nanomedicine offers immense potential in the field of Central Nervous System (CNS) disorder treatment, encompassing conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and stroke.<h4>Method</h4>Through the utilization of nanotechnology-driven drug delivery sys... |
40114302 | CDRxAbs: antibody small-molecule conjugates with computationally designed target-binding synergy. | Bioconjugates as therapeutic modalities combine the advantages and offset the disadvantages of their constituent parts to achieve a refined spectrum of action. We combine the concept of bioconjugation with the full atomic simulation capability of computational protein design to define a new class of molecular recogniti... |
40109459 | [Clinical Manifestations of Early-Onset Capillary Leak Syndrome in Patients With Multiple Organ Failure Due to Severe Acute Pancreatitis]. | <h4>Objective</h4>To investigate the early dynamic changes of biomarkers associated with capillary leak syndrome (CLS) in patients with severe acute pancreatitis (SAP) and their correlation with multiple organ failure (MOF).<h4>Methods</h4>A total of 171 SAP patients admitted to the West China Centre of Excellence for ... |
40094093 | Isolation and Preliminary Characterization of a Novel scFv against <i>SARS-CoV-2</i> : an Experimental and Computational Analysis. | <h4>Background</h4>Since the initial outbreak, the <i>SARS-CoV-2</i> virus has continued to circulate and mutate, resulting in the emergence of new viral sublineages. Due to the lack of effective protection and therapeutic measures against these new variants, the virus is able to further evolve and diversify. This stud... |
40084517 | Immunotherapy in Cervical Cancer: An Evolutionary Paradigm in Women's Reproductive Health. | Cervical cancer is the fourth most common cause of morbidity and mortality in women. The major causative factor for cervical cancer is primary prolonged infection with human papillomavirus, along with secondary factors such as immunodeficiency, smoking, low socioeconomic standards, poor hygiene, and overuse of oral con... |
40082732 | Recent advances in genetic engineering and chemical production in yeast species. | Yeasts have emerged as well-suited microbial cell factory for the sustainable production of biofuels, organic acids, terpenoids, and specialty chemicals. This ability is bolstered by advances in genetic engineering tools, including CRISPR-Cas systems and modular cloning in both conventional (Saccharomyces cerevisiae) a... |
40078221 | From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease. | Peripheral neuropathies are disorders affecting the peripheral nervous system. Among them, Charcot-Marie-Tooth disease is an inherited sensorimotor neuropathy for which no effective treatment exists yet. Research on Charcot-Marie-Tooth disease has been hampered by difficulties in accessing relevant cells, such as senso... |
40078220 | Bioactivated scaffolds promote angiogenesis and lymphangiogenesis for dermal regeneration in vivo. | Chronic wounds represent an unresolved medical challenge with significant impact for patients' quality of life and global healthcare. Diverse in origin, ischemic-hypoxic and inflammatory conditions play central roles as pathological features that impede proper tissue regeneration. In this study, we propose an innovativ... |
40071801 | Fracture risk assessment based on FRAX scores and Polish guidelines in patients with newly diagnosed osteopaenia. | <h4>Introduction</h4>A densitometric diagnosis of osteoporosis qualifies patients to a diagnostic-therapeutic process, but densitometric evaluation may not be sufficient for osteopaenic patients. Therefore, it is essential to assess osteoporosis risk factors, fracture history, and 10-year fracture risk, and classify pa... |
40071802 | Assessment of fracture risk based on FRAX score and Polish guidelines in patients with newly diagnosed osteoporosis. | <h4>Introduction</h4>The authors of the latest recommendations state that osteoporosis diagnosis should not rely solely on densitometric (DXA) criteria. Fracture risk assessment is crucial for determining diagnosis and intervention thresholds. Comprehensive assessment of fracture risk requires consideration of bone min... |
40070795 | Depletion of nuclear cytoophidia in Alzheimer's disease. | There is considerable evidence for a role for metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer's disease (AD). Purine nucleotide synthesis in the brain is regulated with high fidelity to co-ordinate supply with demand. The assembly of some purine biosynthetic ... |
39869729 | Screening for Osteoporosis to Prevent Fractures: An Evidence Review for the U.S. Preventive Services Task Force | <h4>Purpose</h4>To review the evidence on screening for osteoporosis to prevent fractures in community-dwelling adults in primary care settings.<h4>Data sources</h4>MEDLINE, Embase, the Cochrane Library, and trial registries through January 9, 2024; bibliographies from retrieved articles, outside experts, and surveilla... |
40060333 | Multiplexed fiber meta-tip-based circular polarimetry for label-free pathological analysis of ischemic stroke. | <h4>Significance</h4>We present an optical technology for a full-process label-free method for brain slice screening. This proposed multiplexed circular polarimetric method has the advantages of simple operation and high accuracy which may provide easily accessible evidence for the future diagnosis of related diseases.... |
40040782 | Critical reflections on medication overuse headache in patients with migraine: An unsolved riddle in nociception. | Migraine chronification very frequently exposes patients to the inevitable risk of excessive symptomatic intake that, in turn, prompts development of medication overuse headache (MOH). The latter further compromises headache severity establishing a vicious cycle of symptomatic intake and relapsing head pain that critic... |
40036690 | TransHLA: a Hybrid Transformer model for HLA-presented epitope detection. | <h4>Background</h4>Precise prediction of epitope presentation on human leukocyte antigen (HLA) molecules is crucial for advancing vaccine development and immunotherapy. Conventional HLA-peptide binding affinity prediction tools often focus on specific alleles and lack a universal approach for comprehensive HLA site ana... |
40029599 | Cyclodextrin Nanoparticles and Injectable Polymer-Nanoparticle Hydrogels for Macrophage-Targeted Delivery of Small-Molecule Drugs. | Small-molecule drugs are pillars of modern medicine, used to prevent and treat a plethora of diseases. Their applications include modulating the immune response, where macrophages and other phagocytic innate immune cells are critical therapeutic targets. In comparison to biologics, small-molecule drugs benefit from rel... |
40029595 | Peptide-Coated Nanoparticles for Noninvasive Biomedical Imaging. | Nanoparticles (NPs) are materials with overall dimensions ranging between 1 and 100 nm. The application of NPs in medicine has been extensively explored in recent years and had a significant impact on treatment of many diseases, especially cancer. NPs are used to overcome the limitations of standard therapies involving... |
40029593 | Metal-Organic Framework Thin Films as Drug Delivery Systems. | Selective metal-organic frameworks (MOFs) have been studied as promising candidates for biomedical applications, especially as drug delivery systems due to their exceptional structural properties. This work reports the detailed methods to prepare an iron-containing MOF, MIL-88B(Fe), on functionalized gold and medical-g... |
40012244 | Transcriptome sequencing and metabolome analysis to reveal renewal evidence for drought adaptation in mulberry. | As an economically important tree species, mulberry (Morus spp.) has exhibited a remarkable tolerance for salinity, drought and heavy metals. However, the precise mechanism of metabolome-mediated drought adaptation is unclear. In this study, two new mulberry varieties-'drought-sensitive guisangyou62 (GSY62) and highly ... |
39988437 | [Real-world Study of Icotinib in EGFR Mutant Non-small Cell Lung Cancer
Based on the Therapeutic Drug Monitoring]. | <h4>Background</h4>In the real world, the plasma drug concentration range of Icotinib treated with epidermal growth factor receptor (EGFR) gene mutant non-small cell lung cancer (NSCLC) is not yet clear, and there may be a correlation between drug concentration and its efficacy, as well as adverse reactions. This study... |
39980665 | Structural, biological, and biomedical implications of mRNA interactions with the master regulator HuR. | Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein (RBP) that has been implicated in a vast range of biological processes including stress response, angiogenesis, cell proliferation, and differentiation. Dysregulation of HuR has been linked to a number of pathological disorders including vascular dis... |
39967756 | Glass Microwave Microfluidic Devices for Broadband Characterization of Diverse Fluids. | We demonstrate a glass microwave microfluidic device for determining the permittivity of a wide range of liquid chemicals from 100 MHz to 30 GHz with associated uncertainties. Conventional microwave microfluidic devices use polymer-based microfluidic layers for fluid delivery, but these polymers swell in organic solven... |
39967319 | The effect of chemical fixation with paraformaldehyde, glutardialdehyde or methanol on immunofluorescence staining of neutrophils and neutrophil extracellular traps. | The formation of neutrophil extracellular traps (NETs) is known as an important part of the innate immune response. Still, some mechanisms regarding their formation and role during a disease are not completely understood yet. To visualize NETs by immunofluorescence microscopy, a chemical fixation is required. Therefore... |
39962957 | Rapid Detection of Soil Available Phosphorus using Capacitively Coupled Contactless Conductivity Detection. | <h4>Background</h4>In China, the traditional method for analyzing soil available phosphorus is inadequate for large-scale soil assessment and nationwide soil formulation demands. To address this, we propose a rapid and reliable method for soil-available phosphorus detection. The setup includes an on-site rapid pre-trea... |
39950285 | Nanotechnology-based Approaches for Targeted Drug Delivery to the Small Intestine: Advancements and Challenges. | Nanotechnology has emerged as a promising avenue for targeted drug delivery to the small intestine, offering precise control over drug release and enhanced therapeutic efficacy. This review discusses recent advancements and challenges in nanotechnology-based approaches for targeted drug delivery to the small intestine.... |
39950263 | Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers. | Intrinsically disordered proteins (IDPs) are proteins that, despite lacking a defined 3D structure, are capable of adopting dynamic conformations. This structural adaptability allows them to play not only essential roles in crucial cellular processes, such as subcellular organization or transcriptional control, but als... |
39944519 | The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies. | Anthropogenic climate change, primarily driven by greenhouse gas emissions, is reshaping ecosystems and creating conditions that affect 58% of all known human infectious diseases, including fungal infections. Specifically, increasing temperatures, changing precipitation patterns, and extreme weather events are influenc... |
39943668 | Comparison of dermal and eschar fibroblasts in full skin equivalents. | Full-thickness burn wounds pose significant problems, demanding specialised therapies to avoid complications and promote recovery. Eschar tissue, which forms in response to severe burns, contains viable fibroblasts, which migrate from the surrounding tissue in response to burn injury and exhibit a myofibroblast phenoty... |
39929622 | [Exploration of differences in decoction phase state, material form, and crystal form between Glycyrrhizae Radix et Rhizoma-Gypsum Fibrosum and Glycyrrhizae Radix et Rhizoma-CaSO_4·2H_2O based on supramolecules of traditional Chinese medicine]. | With Glycyrrhizae Radix et Rhizoma-Gypsum Fibrosum drug pair as the research object, supramolecular chemistry of traditional Chinese medicine(TCM) was used to study differences between the compatibility of herbal medicine Glycyrrhizae Radix et Rhizoma with mineral medicine Gypsum Fibrosum and its main component CaSO_4·... |
39927970 | High-Speed Combinatorial Polymerization through Kinetic-Trap Encoding. | Like the letters in the alphabet forming words, reusing components of a heterogeneous mixture is an efficient strategy for assembling a large number of target structures. Examples range from synthetic DNA origami to proteins self-assembling into complexes. The standard self-assembly paradigm views target structures as ... |
39917042 | A review on green synthesis of silver nanoparticles (SNPs) using plant extracts: a multifaceted approach in photocatalysis, environmental remediation, and biomedicine. | A sustainable and viable alternative for conventional chemical and physical approaches is the green production of silver nanoparticles (SNPs) using plant extracts. This review centers on the diverse applications of plant-mediated SNPs in biomedicine, environmental remediation, and photocatalysis. <i>Ocimum sanctum</i> ... |
39911550 | Sticky tubes co-assembled by functionalised diphenylalanine and polydopamine nanoparticles form biocompatible antifouling coating. | The persistent challenge of biofouling, driven by the accumulation of microorganisms and biological residues on surfaces, undermines operational efficiency and safety across multiple industries. Functionalized peptide based biocompatible and supramolecular coating can provide a substantial solution to this crucial issu... |
39911546 | Syntheses of cyclic polylactides and the problem of catenane formation. | Cyclic poly(l-lactide)s (PLAs) were prepared in bulk either by ring-expansion polymerization (REP) or by ring-opening polymerization (ROP) with simultaneous polycondensation (ROPPOC). In contrast to REP the latter method involves formation of linear chains and thus, may involve formation of polydisperse catenanes that ... |
39911544 | Quinoline analogs: multifaceted heterocyclic compounds with varied synthetic strategies and potent antitubercular properties. | Tuberculosis cases have continuously increased by 64% over the last nine years, from 2014 to 2023. Approximately 33% of the global population is affected by TB. It is a bacterial disease, and <i>Mycobacterium tuberculosis</i> is the most common bacteria that affects the lungs of human beings during the infection. Other... |
39911542 | Lithium phthalocyanine (γ-structure) as a molecular oxygen sensor. | Synthesis and characterization of lithium phthalocyanine radicals were performed, which were followed by an investigation on its ability to detect oxygen levels in biologically relevant concentrations. EPR studies confirmed the presence of at least two phases, one sensitive to oxygenation (γ-phase) and the second one i... |
39911541 | Advances in pyrazolo[1,5-<i>a</i>]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment. | Pyrazolo[1,5-<i>a</i>]pyrimidines are a notable class of heterocyclic compounds with potent protein kinase inhibitor (PKI) activity, playing a critical role in targeted cancer therapy. Protein kinases, key regulators in cellular signalling, are frequently disrupted in cancers, making them important targets for small-mo... |
39906640 | High-valent oxovanadium metallosupramolecular species as catalysts for the oxidation of benzyl alcohol derivatives. | Coordination-driven synthesis has been successfully utilized to prepare vanadium-based metallosupramolecular species. By systematically varying synthesis methods and reaction conditions, two series of isostructural oxovanadium(v) coordination polymers [VO(SIH)(OR)] <sub><i>n</i></sub> (where SIH<sup>2-</sup> represents... |
39906614 | Synergistic effect of cold atmospheric plasma and methylene blue loaded nano micelles on treating human glioblastoma cells: An in vitro and molecular dynamics study. | <h4>Objectives</h4>One of the most recent cancer treatment methods is cold atmospheric plasma (CAP), which destroys cancer cells without affecting healthy cells. Also, the created photons in the CAP flame can be used to excite a proper photosensitizing agent (PS). Therefore, using nano micelle systems containing a prop... |
39906612 | Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes. | <h4>Objectives</h4>Insulin resistance (IR) is a critical component of metabolic syndrome, primarily linked to obesity. It contributes to impaired glucose metabolism, beta-cell dysfunction, and the onset of type 2 diabetes. This study aimed to develop a DNAsome nanocarrier designed for the targeted delivery of small int... |
39902766 | Leveraging supramolecular systems in biomedical breakthroughs. | Supramolecular systems, intricate assemblies of molecular subunits organized through various intermolecular interactions, offer versatile platforms for diverse applications, including gene therapy, antimicrobial therapy, and cellular engineering. These systems are cost-effective and environmentally friendly, contributi... |
39902106 | Porphyrin-based porous organic polymer for the NIR-enhanced delivery of bupivacaine towards pain management in bacterial infection therapy. | Antibiotic-free strategies have gained widespread attention in combating bacterial infection-related wound therapy. Phototherapy is a precise treatment method that stands out from other therapeutic strategies. However, under the stimulus of local heat, patients might unconsciously touch the dressing at the infection si... |
39902105 | Room temperature sensing of CO<sub>2</sub> using <i>C</i>3-symmetry pyridinium-based porous ionic polymers with triazine or benzene cores. | A new class of ionic polymers tethering triazine (benzene) core hybrids with three dipyridinium as cationic counterparts combined with bromide and/or chloride anions PPyBz-O<sub>Br</sub> and PPyTri-O<sub>Cl</sub> were successfully prepared <i>via</i> the alkylation of 4,4'-dipyridyl derivatives 4,4'-bp-O with 1,3,5-tri... |
39901678 | Synthesis, Anticancer Activity, and Mitochondria-targeted Bioimaging Applications of Novel Fluorescent Calix [4]arenes-benzimidazole Derivatives. | <h4>Background</h4>Calix[n]arenes have attracted great attention due to their biocompatibility and superior stability. When the necessary functional groups are attached to these compounds, they may have the potential to target tumor tissues. Benzimidazoles are among the anticancer drugs discovered in recent years.<h4>A... |
39898546 | Structural and mechanistic insights into the activation of a short prokaryotic argonaute system from archaeon Sulfolobus islandicus. | Prokaryotic Argonaute proteins (pAgos) defend the host against invading nucleic acids, including plasmids and viruses. Short pAgo systems confer immunity by inducing cell death upon detecting invading nucleic acids. However, the activation mechanism of the SiAgo system, comprising a short pAgo from the archaeon Sulfolo... |
39889181 | Role of the AKT signaling pathway in regulating tumor-associated macrophage polarization and in the tumor microenvironment: A review. | Tumor-associated macrophages (TAMs) are present in and are important components of the tumor microenvironment (TME). TAMs differentiate into 2 functionally distinct morphologies, classically activated (M1)-type TAMs and alternatively activated (M2)-type TAMs, when stimulated by different cytokines. The 2 types of TAMs ... |
39888017 | Natural products against tau hyperphosphorylation-induced aggregates: Potential therapies for Alzheimer's disease. | Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairments and is considered the most prevalent form of dementia. Among the contributing factors to AD lies the hyperphosphorylation of the microtubule-associated protein tau. Phosphorylated tau reduces i... |
39883012 | RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. | RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding proteins (G4BPs) in cells. rG4-G4BP complexes have been associated with human diseases, making them important targets for drug development. ... |
39877933 | Flotillins in membrane trafficking and physiopathology. | Flotillin 1 and 2 are highly conserved and homologous members of the stomatin, prohibitin, flotillin, HflK/C (SPFH) family. These ubiquitous proteins assemble into hetero-oligomers at the cytoplasmic membrane in sphingolipid-enriched domains. Flotillins play crucial roles in various cellular processes, likely by concen... |
39877639 | Nanoformulation innovations: Revolutionizing precision in migraine therapy. | <h4>Objectives</h4>Migraine, a serious neurological disease that affects millions of people worldwide, is one of the most considerable burdens on the healthcare system and has significant economic implications. Even though various treatment methods are available, including medication, lifestyle changes, and behavioral ... |
39874016 | Screening of Oncogenic Proteins and Development of a Multiepitope Peptide Vaccine Targeting AKT1 and PARP1 for Breast Cancer by Integrating Reverse Vaccinology and Immune-Informatics Approaches. | <h4>Background</h4>Breast cancer remains a significant global health challenge, requiring innovative therapeutic strategies. In silico methods, which leverage computational tools, offer a promising pathway for vaccine development. These methods facilitate antigen identification, epitope prediction, immune response mode... |
39873980 | Emerging Research and Future Directions on Doxorubicin: A Snapshot. | Doxorubicin, a widely used anthracycline antibiotic, has been a cornerstone in cancer chemotherapy since the 1960s. In addition to doxorubicin, anthracycline chemotherapy medications include daunorubicin, idarubicin, and epirubicin. For many years, doxorubicin has been the chemotherapy drug of choice for treating a bro... |
39868533 | Proximity-activated guide RNA of CRISPR-Cas12a for programmable diagnostic detection and gene regulation. | The flexibility and programmability of CRISPR-Cas technology have made it one of the most popular tools for biomarker diagnostics and gene regulation. Especially, the CRISPR-Cas12 system has shown exceptional clinical diagnosis and gene editing capabilities. Here, we discovered that although the top loop of the 5' hand... |
39868648 | Ring A Cleaving Beta-Diketone Hydrolase Is a Key Enzyme of Steroid Degradation in Anaerobic Bacteria. | Bacterial degradation of ubiquitous and persistent steroids such as steroid hormones is important for their removal from the environment. Initial studies of steroid degradation in anaerobic bacteria suggested that ring-cleaving hydrolases are involved in oxygen-independent sterane skeleton degradation. However, the enz... |
39868539 | Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability. | The RNA chaperone Hfq plays crucial roles in bacterial gene expression and is a major facilitator of small regulatory RNA (sRNA) action. The toroidal architecture of the Hfq hexamer presents three well-characterized surfaces that allow it to bind sRNAs to stabilize them and engage target transcripts. Hfq-interacting sR... |
39865621 | Multifaceted Analysis of Lactobacillus plantarum DMR14 Reveals Promising Antidiabetic Properties Through In Vivo Assays and Molecular Simulations. | Due to the growing concern about diabetes worldwide, we investigated the antidiabetic potential of Lactobacillus plantarum DMR14, assessing its effects on the diabetic mice and identifying safe, bioactive compounds targeting DPP4 protein for drug development through various methods, including in vivo assays, GC-MS anal... |
39867589 | Exploration of degrons and their ability to mediate targeted protein degradation. | Degrons are short amino acid sequences that can facilitate the degradation of protein substrates. They can be classified as either ubiquitin-dependent or -independent based on their interactions with the ubiquitin proteasome system (UPS). These amino acid sequences are often found in exposed regions of proteins serving... |
39866599 | Electrochemical Monitoring of Vitamins B<sub>9</sub> and C in Environmental Matrices with an Oligo Diaminotriazole Electrode. | Chemical polymerization/oligomerization opens numerous opportunities, from fundamental materials research to practical applications in catalysis, energy, sensing, and medicine. The electrochemical detection of vitamins B<sub>9</sub> (folic acid) and C (ascorbic acid) requires new approaches because of low selectivity, ... |
39865541 | Achieving Pressure Consistency in Mechanochemical Simulations of Chemical Reactions Under Pressure. | The eXtended Hydrostatic Compression Force Field (X-HCFF) is a mechanochemical approach in which a cavity is used to exert hydrostatic pressure on a target system. The cavity used in this method is set up to represent the van der Waals (VDW) surface of the system by joining spheres sized according to the respective ato... |
39865335 | FDA-approved drugs featuring macrocycles or medium-sized rings. | Macrocycles or medium-sized rings offer diverse functionality and stereochemical complexity in a well-organized ring structure, allowing them to fulfill various biochemical functions, resulting in high affinity and selectivity for protein targets, while preserving sufficient bioavailability to reach intracellular compa... |
39862093 | Atomized Neutrophil Membrane-coated MOF Nanoparticles for Direct Delivery of Dexamethasone for Severe Pneumonia. | <h4>Background</h4>Dexamethasone has proven life-saving in severe acute respiratory syndrome (SARS) and COVID-19 cases. However, its systemic administration is accompanied by serious side effects. Inhalation delivery of dexamethasone (Dex) faces challenges such as low lung deposition, brief residence in the respiratory... |
39861694 | Peptides as Versatile Regulators in Cancer Immunotherapy: Recent Advances, Challenges, and Future Prospects. | The emergence of effective immunotherapies has revolutionized therapies for many types of cancer. However, current immunotherapy has limited efficacy in certain patient populations and displays therapeutic resistance after a period of treatment. To address these challenges, a growing number of immunotherapy drugs have ... |
39861693 | Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy. | <b>Background:</b> Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by chronic inflammation and joint damage. Despite advancements in treatment, complete remission remains elusive. <b>Methods:</b> In this study, we introduce a novel lipid nanoparticle formulation co-delivering hydroxychloro... |
39861692 | Therapeutic Efficacy of Intranasal <i>N</i>-Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice. | <b>Background/Objectives</b>: We previously demonstrated that the intranasal administration of cell-penetrating Tat peptide-modified carrier, PEG-PCL-Tat, improves drug delivery to the central nervous system. This study aimed to evaluate the potential of the post-onset intranasal administration of <i>N</i>-acetyl-L-cys... |
39858592 | The Expanding Universe of Extensions and Tails: Ribosomal Proteins and Histones in RNA and DNA Complex Signaling and Dynamics. | This short review bridges two biological fields: ribosomes and nucleosomes-two nucleoprotein assemblies that, along with many viruses, share proteins featuring long filamentous segments at their N- or C-termini. A central hypothesis is that these extensions and tails perform analogous functions in both systems. The evo... |
39854052 | Indole-3-Lactic Acid Inhibits Doxorubicin-Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway. | The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which is primarily attributed to its interaction with iron in mitochondria, leading to lipid peroxidation and myocardial ferroptosis. This study aimed to investigate the role of the gut microbiota-derived metabolite, indole-3-lactic aci... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.